thyroxine has been researched along with Parkinson Disease in 15 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the PD and control groups, previous histories of levothyroxine treatment, goiter, hypothyroidism, thyroiditis, and hyperthyroidism were investigated." | 4.02 | Association Between Thyroid Diseases and Parkinson's Disease: A Nested Case-Control Study Using a National Health Screening Cohort. ( Ahn, JH; Chang, IB; Choi, HG; Kim, JH; Lee, HS; Min, CY; Oh, JK; Song, JH; Wee, JH; Yoo, DM, 2021) |
| "Cognitive deficits are common in Parkinson's disease (PD) patients." | 1.40 | Thyroid status and cognitive function in euthyroid patients with early Parkinson's disease. ( Cho, KH; Choi, KH; Choi, SM; Kim, BC; Kim, JT; Kim, MK; Lee, SH; Nam, TS; Park, MS, 2014) |
| "A key feature of Parkinson's disease is the dopaminergic neuronal cell loss in the substantia nigra pars compacta." | 1.39 | Role of L-thyroxin in counteracting rotenone induced neurotoxicity in rats. ( El-Gamal, A; El-Gamal, M; Ellaithy, A; Helmy, B; Mohamed, M; Reda, A; Salama, M; Sheashaa, H; Sobh, M; Tantawy, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, JH | 1 |
| Lee, HS | 1 |
| Ahn, JH | 1 |
| Oh, JK | 1 |
| Chang, IB | 1 |
| Song, JH | 1 |
| Wee, JH | 1 |
| Min, CY | 1 |
| Yoo, DM | 1 |
| Choi, HG | 1 |
| Choi, SM | 1 |
| Kim, BC | 1 |
| Choi, KH | 1 |
| Nam, TS | 1 |
| Kim, JT | 1 |
| Lee, SH | 1 |
| Park, MS | 1 |
| Kim, MK | 1 |
| Cho, KH | 1 |
| Prakash, KM | 1 |
| Kek, PC | 1 |
| Salama, M | 1 |
| Helmy, B | 1 |
| El-Gamal, M | 1 |
| Reda, A | 1 |
| Ellaithy, A | 1 |
| Tantawy, D | 1 |
| Mohamed, M | 1 |
| El-Gamal, A | 1 |
| Sheashaa, H | 1 |
| Sobh, M | 1 |
| Lancranjan, I | 1 |
| Martinez-Campos, A | 1 |
| Giovannini, P | 1 |
| Novelli, A | 1 |
| Cocchi, D | 1 |
| Caraceni, T | 1 |
| Müller, EE | 1 |
| Berger, JR | 1 |
| Kelley, RE | 1 |
| Geffner, DL | 1 |
| Azukizawa, M | 1 |
| Hershman, JM | 1 |
| Nisula, BC | 1 |
| Glaubiger, GA | 1 |
| Louvet, JP | 1 |
| Chase, N | 1 |
| Burrow, GN | 1 |
| Spaulding, SW | 1 |
| Donabedian, R | 1 |
| Van Woert, M | 1 |
| Ambani, L | 1 |
| Bora, SS | 1 |
| Radichevich, I | 1 |
| Werner, SC | 1 |
| Sirtori, CR | 1 |
| Bolme, P | 1 |
| Azarnoff, DL | 1 |
| Kansal, PC | 1 |
| Buse, J | 1 |
| Talbert, OR | 1 |
| Buse, MG | 1 |
| Ban, Y | 1 |
| Boyd, AE | 1 |
| Lebovitz, HE | 1 |
| Feldman, JM | 1 |
1 review available for thyroxine and Parkinson Disease
| Article | Year |
|---|---|
The endocrine profile of bromocriptine: its application in endocrine diseases.
Topics: Bromocriptine; Cushing Syndrome; Endocrine Glands; Growth Hormone; Hormones; Humans; Huntington Dise | 1981 |
1 trial available for thyroxine and Parkinson Disease
| Article | Year |
|---|---|
Artifactual elevation of PBI from an iodinated dye used to stain medicinal capsules pink.
Topics: Bipolar Disorder; Blood Proteins; Capsules; Carbonates; Chromatography, Paper; Clinical Trials as To | 1969 |
13 other studies available for thyroxine and Parkinson Disease
| Article | Year |
|---|---|
Association Between Thyroid Diseases and Parkinson's Disease: A Nested Case-Control Study Using a National Health Screening Cohort.
Topics: Adult; Aged; Aged, 80 and over; Databases, Factual; Female; Humans; Hyperthyroidism; Hypothyroidism; | 2021 |
Thyroid status and cognitive function in euthyroid patients with early Parkinson's disease.
Topics: Aged; Cognition; Cognitive Dysfunction; Executive Function; Female; Humans; Male; Middle Aged; Neuro | 2014 |
Hyperthyroidism "masked" the levodopa response in newly diagnosed Parkinson's disease patients.
Topics: Antiparkinson Agents; Antithyroid Agents; Benserazide; Carbimazole; Drug Combinations; Female; Grave | 2010 |
Role of L-thyroxin in counteracting rotenone induced neurotoxicity in rats.
Topics: Animals; Catalepsy; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Microglia; Neurop | 2013 |
Thyrotrophin and prolactin responses to thyrotrophin-releasing hormone in patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Benserazide; Carbidopa; Drug Combinations; Female; Humans; Hydraz | 1982 |
Thyroid function in Parkinson disease.
Topics: Aged; Carbidopa; Humans; Hypothyroidism; Levodopa; Middle Aged; Parkinson Disease; Prospective Studi | 1981 |
Propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man.
Topics: Depression, Chemical; Humans; Injections, Intravenous; Male; Myxedema; Parkinson Disease; Propylthio | 1975 |
Effect of a large dose of thyrotrophin releasing factor on pituitary and thyroid function in patients with Parkinsonism.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Parkinson Disease; Pituitary Gland; Prolactin; Thyro | 1976 |
The effect of L-DOPA on the hypothalamic-pituitary-thyroid axis.
Topics: Aged; Female; Humans; Hydroxybutyrates; Hypothalamus; Levodopa; Male; Middle Aged; Parkinson Disease | 1974 |
Metabolic responses to acute and chronic L-dopa administration in patients with parkinsonism.
Topics: 17-Ketosteroids; Acromegaly; Adult; Aged; Antigens; Blood Glucose; Cholesterol; Dihydroxyphenylalani | 1972 |
The effect of L-dopa on plasma growth hormone, insulin, and thyroxine.
Topics: Administration, Oral; Aged; Animals; Blood Glucose; Dihydroxyphenylalanine; Female; Growth Hormone; | 1972 |
[Circadian rhythm of thyroid hormones in the blood].
Topics: Adolescent; Adult; Aged; Circadian Rhythm; Diabetes Mellitus; Drug Hypersensitivity; Humans; Hyperth | 1972 |
Endocrine function and glucose metabolism in patients with Parkinson's disease and their alternation by L-Dopa.
Topics: Adult; Aged; Antibodies; Dihydroxyphenylalanine; Female; Glucose; Gonadotropins; Humans; Insulin; Io | 1971 |