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thyroxine and Osteosarcoma

thyroxine has been researched along with Osteosarcoma in 4 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
" In the dose-response studies, a biphasic increase in medium IGF-I was observed in both cells and limb bones, with peak stimulatory concentrations of 10(-8) M for T3 and 10(-7) M for T4 in both systems."1.29Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue. ( Caplice, MD; Khanna, V; Lakatos, P; Stern, PH, 1993)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Scarlett, A1
Parsons, MP1
Hanson, PL1
Sidhu, KK1
Milligan, TP1
Burrin, JM1
Lakatos, P1
Caplice, MD1
Khanna, V1
Stern, PH1
Banovac, K1
Koren, E1
Atkins, D1
Hunt, NH1
Ingleton, PM1
Martin, TJ1

Other Studies

4 other studies available for thyroxine and Osteosarcoma

ArticleYear
Thyroid hormone stimulation of extracellular signal-regulated kinase and cell proliferation in human osteoblast-like cells is initiated at integrin alphaVbeta3.
    The Journal of endocrinology, 2008, Volume: 196, Issue:3

    Topics: Cell Division; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expre

2008
Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1993, Volume: 8, Issue:12

    Topics: Animals; Bone and Bones; Bone Resorption; Culture Media; Culture Techniques; Dose-Response Relations

1993
Triiodothyronine stimulates the release of membrane-bound alkaline phosphatase in osteoblastic cells.
    Calcified tissue international, 2000, Volume: 67, Issue:6

    Topics: Actins; Alkaline Phosphatase; Animals; Cell Count; Cell Fractionation; Cell Membrane; Cytochalasin B

2000
Rat osteogenic sarcoma cells: isolation and effects of hormones on the production of cyclic AMP and cyclic GMP.
    Endocrinology, 1977, Volume: 101, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Calcitonin; Cyclic AMP; Cyclic GMP; Glucagon; Glucose; Growth

1977