thyroxine has been researched along with Osteosarcoma in 4 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the dose-response studies, a biphasic increase in medium IGF-I was observed in both cells and limb bones, with peak stimulatory concentrations of 10(-8) M for T3 and 10(-7) M for T4 in both systems." | 1.29 | Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue. ( Caplice, MD; Khanna, V; Lakatos, P; Stern, PH, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scarlett, A | 1 |
| Parsons, MP | 1 |
| Hanson, PL | 1 |
| Sidhu, KK | 1 |
| Milligan, TP | 1 |
| Burrin, JM | 1 |
| Lakatos, P | 1 |
| Caplice, MD | 1 |
| Khanna, V | 1 |
| Stern, PH | 1 |
| Banovac, K | 1 |
| Koren, E | 1 |
| Atkins, D | 1 |
| Hunt, NH | 1 |
| Ingleton, PM | 1 |
| Martin, TJ | 1 |
4 other studies available for thyroxine and Osteosarcoma
| Article | Year |
|---|---|
Thyroid hormone stimulation of extracellular signal-regulated kinase and cell proliferation in human osteoblast-like cells is initiated at integrin alphaVbeta3.
Topics: Cell Division; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expre | 2008 |
Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue.
Topics: Animals; Bone and Bones; Bone Resorption; Culture Media; Culture Techniques; Dose-Response Relations | 1993 |
Triiodothyronine stimulates the release of membrane-bound alkaline phosphatase in osteoblastic cells.
Topics: Actins; Alkaline Phosphatase; Animals; Cell Count; Cell Fractionation; Cell Membrane; Cytochalasin B | 2000 |
Rat osteogenic sarcoma cells: isolation and effects of hormones on the production of cyclic AMP and cyclic GMP.
Topics: Adrenocorticotropic Hormone; Animals; Calcitonin; Cyclic AMP; Cyclic GMP; Glucagon; Glucose; Growth | 1977 |