thyroxine has been researched along with Orphan Diseases in 15 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Orphan Diseases: Rare diseases that have not been well studied.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our overall aim is to develop a model that can be applied to optimize dosing in this pediatric patient population since suboptimal treatment of CH during the first 2 years of life is associated with a reduced intelligence quotient between 10 and 14 years." | 5.62 | Modeling of levothyroxine in newborns and infants with congenital hypothyroidism: challenges and opportunities of a rare disease multi-center study. ( Bachmann, F; Gächter, P; Gotta, V; Janner, M; Koch, G; Konrad, D; L'Allemand, D; Leroux, S; Pfister, M; Schropp, J; Steffens, B; Szinnai, G; Welzel, T, 2021) |
| " It results from reduced intracellular action of thyroid hormones (TH) genetically determined and manifests as persistent hyperthyroxinemia with non-suppressed thyroid-stimulating hormone (TSH)." | 3.80 | A case of thyroid hormone resistance: a rare mutation. ( Aragüés, JM; Barbosa, AP; Gonçalves, AP; Mascarenhas, M; Nobre, E, 2014) |
| "Central hypothyroidism is a rare and heterogeneous disorder that is characterized by a defect in thyroid hormone secretion in an otherwise normal thyroid gland due to insufficient stimulation by TSH." | 2.55 | Central hypothyroidism - a neglected thyroid disorder. ( Beck-Peccoz, P; Giavoli, C; Lania, A; Rodari, G, 2017) |
| " Our overall aim is to develop a model that can be applied to optimize dosing in this pediatric patient population since suboptimal treatment of CH during the first 2 years of life is associated with a reduced intelligence quotient between 10 and 14 years." | 1.62 | Modeling of levothyroxine in newborns and infants with congenital hypothyroidism: challenges and opportunities of a rare disease multi-center study. ( Bachmann, F; Gächter, P; Gotta, V; Janner, M; Koch, G; Konrad, D; L'Allemand, D; Leroux, S; Pfister, M; Schropp, J; Steffens, B; Szinnai, G; Welzel, T, 2021) |
| "The diagnosis of Hashimoto's encephalopathy is made when no other cause is found for an acute encephalopathic illness, in the presence of positive thyroid autoantibodies, and is supported by a response to steroid therapy." | 1.40 | Endocrine encephalopathy. ( Hunt, P; Soule, S; Yong, KW, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Koch, G | 1 |
| Steffens, B | 1 |
| Leroux, S | 1 |
| Gotta, V | 1 |
| Schropp, J | 1 |
| Gächter, P | 1 |
| Bachmann, F | 1 |
| Welzel, T | 1 |
| Janner, M | 1 |
| L'Allemand, D | 1 |
| Konrad, D | 1 |
| Szinnai, G | 1 |
| Pfister, M | 1 |
| Beck-Peccoz, P | 1 |
| Rodari, G | 1 |
| Giavoli, C | 1 |
| Lania, A | 1 |
| Szczepanek-Parulska, E | 1 |
| Zybek-Kocik, A | 1 |
| Wartofsky, L | 1 |
| Ruchala, M | 1 |
| Setty, NS | 1 |
| Sadananda, KS | 1 |
| Nanjappa, MC | 1 |
| Patra, S | 1 |
| Basappa, H | 1 |
| Krishnappa, S | 1 |
| Sellappan, B | 1 |
| Chakraborty, M | 1 |
| Cherian, S | 1 |
| Yong, KW | 1 |
| Soule, S | 1 |
| Hunt, P | 1 |
| Rodrigues, F | 1 |
| Grenha, J | 1 |
| Ortez, C | 1 |
| Nascimento, A | 1 |
| Morte, B | 1 |
| M-Belinchón, M | 1 |
| Armstrong, J | 1 |
| Colomer, J | 1 |
| Lang, D | 1 |
| Mead, JS | 1 |
| Sykes, DB | 1 |
| Gonçalves, AP | 1 |
| Aragüés, JM | 1 |
| Nobre, E | 1 |
| Barbosa, AP | 1 |
| Mascarenhas, M | 1 |
| Bandhakavi, M | 1 |
| ALBRIGHT, EC | 1 |
| LARSON, FC | 1 |
| DEISS, WP | 1 |
| LISSITZKY, S | 2 |
| BISMUTH, J | 1 |
| BACKER, ET | 1 |
| HEIDER, JG | 1 |
| BRONK, JR | 1 |
3 reviews available for thyroxine and Orphan Diseases
| Article | Year |
|---|---|
Central hypothyroidism - a neglected thyroid disorder.
Topics: Female; Humans; Hypothalamus; Hypothyroidism; Male; Neglected Diseases; Pituitary Gland; Rare Diseas | 2017 |
Thyroid Hemiagenesis: Incidence, Clinical Significance, and Genetic Background.
Topics: Animals; DNA-Binding Proteins; Female; Genetic Background; Genetic Predisposition to Disease; Humans | 2017 |
Hormones and the bone marrow: panhypopituitarism and pancytopenia in a man with a pituitary adenoma.
Topics: Adenoma; Bone Marrow; Drug Therapy, Combination; Hematologic Tests; Humans; Hypopituitarism; Kidney | 2015 |
12 other studies available for thyroxine and Orphan Diseases
| Article | Year |
|---|---|
Modeling of levothyroxine in newborns and infants with congenital hypothyroidism: challenges and opportunities of a rare disease multi-center study.
Topics: Child, Preschool; Congenital Hypothyroidism; Female; Humans; Infant; Infant, Newborn; Longitudinal S | 2021 |
Massive pericardial effusion and cardiac tamponade due to cholesterol pericarditis in a case of subclinical hypothyroidism: a rare event.
Topics: Biopsy, Needle; Blood Chemical Analysis; Cardiac Tamponade; Echocardiography, Doppler; Female; Follo | 2014 |
Congenital hypothyroidism presenting as pseudo-obstruction in preterm infants.
Topics: Congenital Hypothyroidism; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Infant, Newbo | 2014 |
Endocrine encephalopathy.
Topics: Autoantibodies; Brain Diseases; Encephalitis; Female; Follow-Up Studies; Hashimoto Disease; Humans; | 2014 |
Hypotonic male infant and MCT8 deficiency - a diagnosis to think about.
Topics: Child, Preschool; Humans; Male; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; Musc | 2014 |
A case of thyroid hormone resistance: a rare mutation.
Topics: Aged; DNA; Exons; Female; Genes, erbA; Goiter; Humans; Hyperthyroxinemia; Mutation; Polymerase Chain | 2014 |
Periodic paralysis as an unusual presentation of autoimmune hypothyroidism with goiter.
Topics: Autoantibodies; Child; Female; Goiter; Humans; Hypokalemic Periodic Paralysis; Hypothyroidism; Rare | 2009 |
Single dimension chromatographic separation of thyroxin and triiodothyronine.
Topics: Chromatography; Rare Diseases; Retinal Degeneration; Retinal Detachment; Thyroxine; Triiodothyronine | 1953 |
[Separation of iodothyronines of biologic interest by paper electrophoresis].
Topics: Biological Products; Electrophoresis; Electrophoresis, Paper; Rare Diseases; Retinal Degeneration; R | 1954 |
[Separation and determination of iodized serum components by dextran gel (sephadex) filtration].
Topics: Blood Chemical Analysis; Chromatography; Dextrans; Diiodotyrosine; Filtration; Humans; Iodine Isotop | 1963 |
[A METHOD FOR THE DETERMINATION OF THYROXIN AND TRIIODOTHYRONINE AFTER PAPER CHROMATOGRAPHIC SEPARATION].
Topics: Chemistry Techniques, Analytical; Chromatography; Chromatography, Paper; Rare Diseases; Thyroxine; T | 1963 |
A RAPID SEPARATION OF THYROXINE AND SOME OF ITS ANALOGUES BY THIN-LAYER CHROMATOGRAPHY.
Topics: Chromatography; Chromatography, Thin Layer; Organic Chemicals; Rare Diseases; Research; Thyroid Horm | 1965 |