thyroxine has been researched along with Noonan Syndrome in 2 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Noonan Syndrome: A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype bears similarities to that of TURNER SYNDROME that occurs only in females and has its basis in a 45, X karyotype abnormality. Noonan syndrome occurs in both males and females with a normal karyotype (46,XX and 46,XY). Mutations in a several genes (PTPN11, KRAS, SOS1, NF1 and RAF1) have been associated the NS phenotype. Mutations in PTPN11 are the most common. LEOPARD SYNDROME, a disorder that has clinical features overlapping those of Noonan Syndrome, is also due to mutations in PTPN11. In addition, there is overlap with the syndrome called neurofibromatosis-Noonan syndrome due to mutations in NF1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Differentiated thyroid cancer (DTC) is a rare malignant disease, although its incidence has increased over the last few decades." | 2.55 | Differentiated Thyroid Cancer-Treatment: State of the Art. ( Grosse, J; Hellwig, D; Menhart, K; Schmidbauer, B, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schmidbauer, B | 1 |
| Menhart, K | 1 |
| Hellwig, D | 1 |
| Grosse, J | 1 |
| Romano, AA | 1 |
| Blethen, SL | 1 |
| Dana, K | 1 |
| Noto, RA | 1 |
1 review available for thyroxine and Noonan Syndrome
| Article | Year |
|---|---|
Differentiated Thyroid Cancer-Treatment: State of the Art.
Topics: Adenocarcinoma; Adenocarcinoma, Follicular; Carcinoma, Papillary; Drug Therapy; Enzyme Inhibitors; H | 2017 |
1 other study available for thyroxine and Noonan Syndrome
| Article | Year |
|---|---|
Growth hormone treatment in Noonan syndrome: the National Cooperative Growth Study experience.
Topics: Adolescent; Adult; Body Height; Child; Databases, Factual; Drug Information Services; Female; Growth | 1996 |