thyroxine has been researched along with Nervous System Diseases in 25 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| " When the intake is restricted, physiological adaptation is progressively replaced by pathological alterations, in parallel with the degree of iodine deprivation, leading to excessive glandular stimulation, hypothyroxinemia, and goiter formation." | 8.82 | Feto-maternal repercussions of iodine deficiency during pregnancy. An update. ( Glinoer, D, 2003) |
| " When the intake is restricted, physiological adaptation is progressively replaced by pathological alterations, in parallel with the degree of iodine deprivation, leading to excessive glandular stimulation, hypothyroxinemia, and goiter formation." | 4.82 | Feto-maternal repercussions of iodine deficiency during pregnancy. An update. ( Glinoer, D, 2003) |
| "After 12 weeks of treatment (before pregnancy), iodine concentrations in urine and thyroid tissue and circulating thyroxine of adult females correlated with iodine intake." | 3.78 | Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring. ( Fan, C; Li, J; Liu, Y; Mao, J; Shan, Z; Teng, W; Wang, H; Zhang, H; Zhang, L, 2012) |
| "Recently, a transthyretin variant, TTR Met 119, in which methionine substitutes for threonine 119, a component of the protein's iodothyronine binding site, was identified in individuals with transient euthyroid hyperthyroxinemia." | 3.68 | Thyroxine binding in a TTR Met 119 kindred. ( Almeida, MR; Altland, K; Alves, IL; Coelho, T; Costa, PP; Divino, CM; Palha, JA; Saraiva, MJ; Schussler, GC, 1993) |
| " Alterations in TTR structure can manifest clinically as familial amyloidotic polyneuropathy or euthyroid hyperthyroxinemia." | 3.68 | Thyroxine interactions with transthyretin: a comparison of 10 different naturally occurring human transthyretin variants. ( Benson, MD; Liepnieks, JJ; Moses, AC; Murrell, JR; Rosen, HN, 1993) |
| "Endemic cretinism is still present in an endemic goiter area of the central Apennines (Montefeltro) (goiter prevalence 55%; mean urinary iodine level 39 micrograms/g creatinine)." | 3.68 | Clinical picture of endemic cretinism in central Apennines (Montefeltro). ( Andreani, M; Antonelli, A; Baschieri, L; Bertoni, F; Donati, L; Filippi, T; Gasperini, L; Moscogiuri, D; Neri, S; Venturi, S, 1992) |
| "The frequency of SH in children with neurological disorders was of 7." | 1.32 | [Frequency of subclinical hypothyroidism among healthy children and those with neurological conditions in the state of Mérida, Venezuela]. ( Arata-Bellabarba, G; Arias-Ferreira, A; Bianchi, G; Jiménez-López, V; Mamán-Alvarado, D; Paoli-Valeri, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 9 (36.00) | 29.6817 |
| 2010's | 7 (28.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 1 |
| Huang, J | 1 |
| Aximujiang, K | 1 |
| Xu, C | 1 |
| Ahemaiti, A | 1 |
| Wu, G | 1 |
| Zhong, L | 1 |
| Yunusi, K | 1 |
| Roelfsema, F | 1 |
| Veldhuis, JD | 1 |
| Vieira, M | 1 |
| Saraiva, MJ | 2 |
| Hollanders, JJ | 1 |
| Israëls, J | 1 |
| van der Pal, SM | 1 |
| Verkerk, PH | 1 |
| Rotteveel, J | 1 |
| Finken, MJ | 1 |
| Joseph, R | 1 |
| Linn, M | 1 |
| Yoder, BA | 1 |
| Clark, RH | 1 |
| Le Toux, AL | 1 |
| Marliot, C | 1 |
| Ramakers, M | 1 |
| Hazera, P | 1 |
| Zhang, L | 1 |
| Teng, W | 1 |
| Liu, Y | 1 |
| Li, J | 1 |
| Mao, J | 1 |
| Fan, C | 1 |
| Wang, H | 1 |
| Zhang, H | 1 |
| Shan, Z | 1 |
| Soldin, OP | 1 |
| Lai, S | 1 |
| Lamm, SH | 1 |
| Mosee, S | 1 |
| Glinoer, D | 2 |
| Morreale de Escobar, G | 1 |
| Hume, R | 1 |
| Paoli-Valeri, M | 1 |
| Mamán-Alvarado, D | 1 |
| Jiménez-López, V | 1 |
| Arias-Ferreira, A | 1 |
| Bianchi, G | 1 |
| Arata-Bellabarba, G | 1 |
| Zoeller, RT | 1 |
| Bigelow, C | 1 |
| Rovet, J | 1 |
| de Luis, DA | 1 |
| Abad, L | 1 |
| Aller, R | 1 |
| González-Sagrado, M | 1 |
| Dueñas, A | 1 |
| Hulse, A | 1 |
| Alves, IL | 1 |
| Divino, CM | 1 |
| Schussler, GC | 1 |
| Altland, K | 1 |
| Almeida, MR | 1 |
| Palha, JA | 1 |
| Coelho, T | 1 |
| Costa, PP | 1 |
| Rosen, HN | 1 |
| Moses, AC | 1 |
| Murrell, JR | 1 |
| Liepnieks, JJ | 1 |
| Benson, MD | 2 |
| Seppel, T | 1 |
| Becker, A | 1 |
| Lippert, F | 1 |
| Schlaghecke, R | 1 |
| Linquette, M | 1 |
| Lefebvre, J | 1 |
| Van Parys, C | 1 |
| Wemeau, JL | 1 |
| Donati, L | 1 |
| Antonelli, A | 1 |
| Bertoni, F | 1 |
| Moscogiuri, D | 1 |
| Andreani, M | 1 |
| Venturi, S | 1 |
| Filippi, T | 1 |
| Gasperini, L | 1 |
| Neri, S | 1 |
| Baschieri, L | 1 |
| Refetoff, S | 1 |
| Dwulet, FE | 1 |
| Green, D | 1 |
| Smith, NJ | 1 |
| Vivanco, F | 1 |
| Busturia, MA | 1 |
| Ramos, F | 1 |
| Sanchez-Martin, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comprehensive Retrospective Study of Cerebral MRI Anomalies in Mutated Transthyretin Amyloidosis Patients[NCT05075798] | 36 participants (Actual) | Observational | 2021-10-25 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for thyroxine and Nervous System Diseases
| Article | Year |
|---|---|
Thyrotropin secretion patterns in health and disease.
Topics: Adult; Animals; Circadian Rhythm; Female; Health Status; Humans; Hypothalamo-Hypophyseal System; Hyp | 2013 |
Transthyretin: a multifaceted protein.
Topics: Animals; Choroid Plexus; Humans; Liver; Nervous System Diseases; Prealbumin; Retinol-Binding Protein | 2014 |
Neuro-developmental deficits in early-treated congenital hypothyroidism.
Topics: Adolescent; Adult; Child; Child, Preschool; Congenital Hypothyroidism; Developmental Disabilities; H | 2008 |
Feto-maternal repercussions of iodine deficiency during pregnancy. An update.
Topics: Diet; Female; Goiter; Humans; Intellectual Disability; Iodine; Nervous System Diseases; Pregnancy; P | 2003 |
Maternal hypothyroxinemia versus hypothyroidism and potential neurodevelopmental. Alterations of her offspring.
Topics: Brain; Cerebral Palsy; Congenital Hypothyroidism; Embryonic and Fetal Development; Female; Gestation | 2003 |
Neurodisability: metabolic and hormonal aspects.
Topics: Child; Developmental Disabilities; Female; Humans; Hypothyroidism; Iodine; Nervous System Diseases; | 2003 |
Lack of a relation between human neonatal thyroxine and pediatric neurobehavioral disorders: neonatal total thyroxine is not a good proxy measure of maternal thyroid hormone insufficiency.
Topics: Child Behavior Disorders; Female; Humans; Hypothyroidism; Infant, Newborn; Nervous System Diseases; | 2004 |
[Levothyroxine poisoning: clinical manifestations and therapeutic management].
Topics: Adrenergic beta-Antagonists; Antithyroid Agents; Cardiovascular Diseases; Child; Cholestyramine Resi | 2004 |
Pregnancy and iodine.
Topics: Female; Goiter; Humans; Intellectual Disability; Iodine; Maternal-Fetal Exchange; Nervous System Dis | 2001 |
Hemophilia. Current concepts in management.
Topics: Adrenal Cortex Hormones; Adult; Analgesics; Antifibrinolytic Agents; Blood Transfusion; Cardiovascul | 1972 |
1 trial available for thyroxine and Nervous System Diseases
| Article | Year |
|---|---|
Lack of a relation between human neonatal thyroxine and pediatric neurobehavioral disorders.
Topics: Case-Control Studies; Child; Child Behavior Disorders; Child, Preschool; Female; Humans; Infant, New | 2003 |
14 other studies available for thyroxine and Nervous System Diseases
| Article | Year |
|---|---|
Thyroid Dysfunction, Neurological Disorder and Immunosuppression as the Consequences of Long-term Combined Stress.
Topics: Animals; Blood; Colitis, Ulcerative; Colon; Disease Models, Animal; Gene Expression Profiling; Hypot | 2018 |
No Association Between Transient Hypothyroxinemia of Prematurity and Neurodevelopmental Outcome in Young Adulthood.
Topics: Cohort Studies; Congenital Hypothyroidism; Developmental Disabilities; Female; Follow-Up Studies; Hu | 2015 |
Increasing supplemental thyroid hormone use among premature infants born at 23 to 32 weeks' gestation.
Topics: Child; Child, Preschool; Congenital Hypothyroidism; Developmental Disabilities; Hormone Replacement | 2010 |
[Iode poisoning after several bandages].
Topics: Anti-Infective Agents, Local; Bandages; Electroencephalography; Humans; Hydrocarbons, Iodinated; Hyp | 2012 |
Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring.
Topics: Age Factors; Animals; Animals, Newborn; Anti-Infective Agents, Local; Brain-Derived Neurotrophic Fac | 2012 |
[Frequency of subclinical hypothyroidism among healthy children and those with neurological conditions in the state of Mérida, Venezuela].
Topics: Autoantibodies; Child, Preschool; Comorbidity; Developmental Disabilities; Female; Humans; Hypothyro | 2003 |
Congenital hypothyroidism and neurological development.
Topics: Brain; Child; Child Development; Child, Preschool; Congenital Hypothyroidism; Humans; Hypothyroidism | 1983 |
Thyroxine binding in a TTR Met 119 kindred.
Topics: Amyloidosis; Asparagine; Binding Sites; DNA; Female; Genotype; Heterozygote; Humans; Hyperthyroxinem | 1993 |
Thyroxine interactions with transthyretin: a comparison of 10 different naturally occurring human transthyretin variants.
Topics: Amyloidosis; Analysis of Variance; Binding, Competitive; Dose-Response Relationship, Drug; Heterozyg | 1993 |
Serum sex hormone-binding globulin and osteocalcin in systemic nonthyroidal illness associated with low thyroid hormone concentrations.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Cardiovascular Diseases; Communicable Diseases; Female; | 1996 |
[Lithium in the treatment of thyrotoxicosis (author's transl)].
Topics: Carbonates; Drug Evaluation; Female; Humans; Hyperthyroidism; Lithium; Male; Nervous System Diseases | 1978 |
Clinical picture of endemic cretinism in central Apennines (Montefeltro).
Topics: Adult; Aged; Congenital Hypothyroidism; Female; Gait; Humans; Hypothyroidism; Intellectual Disabilit | 1992 |
Reduced affinity for thyroxine in two of three structural thyroxine-binding prealbumin variants associated with familial amyloidotic polyneuropathy.
Topics: Amyloidosis; Heterozygote; Humans; Male; Nervous System Diseases; Prealbumin; Protein Binding; Thyro | 1986 |
Mechanism of the thyroxine prevention against the neurological poisoning induced in rats by , '-iminodipropionitrile.
Topics: Acetates; Animals; Brain; Carbon Isotopes; Cyanides; Liver; Male; Nervous System Diseases; Nitriles; | 1972 |