thyroxine and Myxedema studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Myxedema: A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips.

Research Excerpts

Excerpt	Relevance	Reference
"A 39-year-old woman with primary myxedema, who had the potent activities of thyrotropin-binding inhibitory immunoglobulins (TBII) and thyroid-stimulation blocking antibodies (TSBAb), developed aortitis syndrome about 6 months after the initiation of L-thyroxine (L-T4) supplementation."	7.68	Disappearance of thyroid-stimulation blocking antibody by glucocorticoid therapy in a patient with primary myxedema who developed aortitis syndrome during L-thyroxine supplementation. ( Kouchi, T; Mashiba, H; Mitani, Y; Shigemasa, C; Taniguchi, S, 1990)
"Thyroid microsomal (MAb) and thyroglobulin (TgAb) antibodies were sequentially measured by sensitive and quantitative radioassays in 17 patients with goitrous Hashimoto's thyroiditis (9 hypothyroid, 8 euthyroid) and in 19 patients with idiopathic myxedema before and at various time intervals up to 24-48 months after the institution of L-thyroxine therapy."	7.67	L-thyroxine therapy induces a fall of thyroid microsomal and thyroglobulin antibodies in idiopathic myxedema and in hypothyroid, but not in euthyroid Hashimoto's thyroiditis. ( Chiovato, L; Marcocci, C; Mariotti, S; Mori, A; Pinchera, A, 1986)
"A 76-year-old man who developed the clinical syndrome of myxedema coma was found to have a normal serum thyroxine concentration."	7.66	Myxedema coma and normal serum thyroxine. ( Baldwin, JG; Lizarralde, G; McCulley, HG; Packer, RM, 1978)
"Myxedema coma is a rare endocrine emergency resulting from the decompensation of severe hypothyroidism, which is associated with a high mortality rate."	5.51	Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine. ( Kiyota, A; Okazaki, M; Ozaki, N; Tsuchida, M; Ueda, K, 2019)
"Myxedema coma develops as a consequence of severe hypothyroidism and is characterized by a hypometabolic, stuporous state."	5.31	Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog. ( Dixon, RM; Henik, RA, 2000)
"A 46-year-old woman with hypothyroid Graves' disease (EMO syndrome) is reported."	5.29	Successful treatment of hypothyroid Graves' disease with a combination of levothyroxine replacement, intravenous high-dose steroid and irradiation to the orbit. ( Fujiwara, K; Hayakawa, K; Koh, T; Koshiyama, H; Mori, S, 1993)
"Cortisone therapy was used in 3 patients."	5.28	Myxoedema coma: response of thyroid hormones with oral and intravenous high-dose L-thyroxine treatment. ( Arlot, S; Debussche, X; Fournier, A; Lalau, JD; Mesmacque, A; Quichaud, J; Tolani, M, 1991)
"Amiodarone is a potent new antiarrhythmic drug that has multiple effects on thyroid function, including inhibition of extrathyroidal triiodothyronine production and rarely, iodine-induced hypothyroidism."	5.27	Myxedema coma during long-term amiodarone therapy. ( Cantley, LK; Dalldorf, FG; Foster, JR; Mazonson, PD; Utiger, RD; Williams, ML, 1984)
"Myxoedema coma is fortunately rare and is probably rarer in a warm climate such as Australia."	5.26	A case of myxoedema coma successfully treated by low dose oral triiodothyronine. ( Graham, JJ; Harding, PE, 1977)
" Myxedema coma is a rare and potentially fatal manifestation of severe hypothyroidism that can be successfully treated using intravenous levothyroxine."	4.84	Hypothyroidism and myxedema coma. ( Finora, K; Greco, D, 2007)
"We report the case of a young woman affected by hypothyroidism due to Hashimoto's thyroiditis, previously well compensated with a full replacement therapy (150 mcg/day of levothyroxine), presenting a clinical picture of myxedema, with a TSH=650 mU/L."	3.80	Sevelamer carbonate markedly reduces levothyroxine absorption. ( Giagulli, VA; Guastamacchia, E; Iovine, N; Iovino, M; Licchelli, B; Petrosino, A; Triggiani, V, 2014)
"The diagnosis of acute pituitary insufficiency with myxedema coma and hypocortisolism was suspected and the patient was treated with parenteral cortisone and L-thyroxine."	3.73	[A rare cause of cardiogenic shock with psychotic symptoms]. ( Christ, E; Fischli, S; Stettler, C, 2006)
" In suspicion of myxedema coma,the patient was treated with high dose L-thyroxine and hydrocortisone for preventing secondary adrenal insufficiency."	3.71	[Myxedema coma as a rare differential diagnosis of severe consciousness disturbance]. ( Bardutzky, J; Kollmar, R; Meisel, F; Schellinger, PD; Schwaninger, M, 2002)
"This article describes a case of primary hyperparathyroidism that was unmasked in a 63-year-old female after the initiation of replacement therapy with L-thyroxine for myxedema."	3.68	Myxedema masking primary hyperparathyroidism. ( Brignol, YF; Peter, SA, 1993)
"Endemic cretinism is still present in an endemic goiter area of the central Apennines (Montefeltro) (goiter prevalence 55%; mean urinary iodine level 39 micrograms/g creatinine)."	3.68	Clinical picture of endemic cretinism in central Apennines (Montefeltro). ( Andreani, M; Antonelli, A; Baschieri, L; Bertoni, F; Donati, L; Filippi, T; Gasperini, L; Moscogiuri, D; Neri, S; Venturi, S, 1992)
"A 39-year-old woman with primary myxedema, who had the potent activities of thyrotropin-binding inhibitory immunoglobulins (TBII) and thyroid-stimulation blocking antibodies (TSBAb), developed aortitis syndrome about 6 months after the initiation of L-thyroxine (L-T4) supplementation."	3.68	Disappearance of thyroid-stimulation blocking antibody by glucocorticoid therapy in a patient with primary myxedema who developed aortitis syndrome during L-thyroxine supplementation. ( Kouchi, T; Mashiba, H; Mitani, Y; Shigemasa, C; Taniguchi, S, 1990)
"Thyroid microsomal (MAb) and thyroglobulin (TgAb) antibodies were sequentially measured by sensitive and quantitative radioassays in 17 patients with goitrous Hashimoto's thyroiditis (9 hypothyroid, 8 euthyroid) and in 19 patients with idiopathic myxedema before and at various time intervals up to 24-48 months after the institution of L-thyroxine therapy."	3.67	L-thyroxine therapy induces a fall of thyroid microsomal and thyroglobulin antibodies in idiopathic myxedema and in hypothyroid, but not in euthyroid Hashimoto's thyroiditis. ( Chiovato, L; Marcocci, C; Mariotti, S; Mori, A; Pinchera, A, 1986)
"Serum thyroxine (T4) and triiodothyronine (T3) levels were measured in a group of thirty-three patients with anorexia nervosa (AN) and compared with twenty-five control women presenting with hirsutism and twenty-one patients with primary myxoedema."	3.66	Serum T3 and T4 levels in patients with anorexia nervosa showing transient hyperthyroidism during weight gain. ( Mills, IH; Moore, R, 1979)
" Treatment with thyroxine resulted in a marked improvement of most of the clinical features of hypothyroidism and some improvement in cardiac function."	3.66	Prolonged persistence of a large pericardial effusion and hemodynamic evidence of cardiac tamponade during treatment of myxedema. ( Das, S; Lieberman, AN; Schussler, GC, 1982)
"In a woman with myxedema and normal total and ionized plasma calcium levels, persistent hypercalcemia developed when she was treated with thyroxine."	3.66	Primary hyperparathyroidism masked by hypothyroidism. ( Lever, EG, 1983)
"A 76-year-old man who developed the clinical syndrome of myxedema coma was found to have a normal serum thyroxine concentration."	3.66	Myxedema coma and normal serum thyroxine. ( Baldwin, JG; Lizarralde, G; McCulley, HG; Packer, RM, 1978)
"Pericardial tamponade developed in a patient with hypothyroidism and a pericardial effusion after she had been successfully treated with levothyroxine sodium."	3.66	Pericardial tamponade in a patient with treated myxedema. ( Arvan, S, 1983)
" We have noted that early in the course of thyroxine (T4) replacement in myxedema, serum T4 concentrations may be transiently elevated before reaching a lower "steady-state" level."	3.66	Transient elevation of serum thyroid hormone concentration after initiation of replacement therapy in myxedema. ( Brown, ME; Refetoff, S, 1980)
"A 54-year-old woman with myxedema had hundreds of discrete cutaneous mucinous papules, which responded dramatically to appropriate replacement therapy with L-thyroxine."	3.66	Multiple cutaneous focal mucinoses with hypothyroidism. ( Jakubovic, HR; Rosenthal, D; Salama, SS, 1982)
"Bradycardia is a well-known cardiac manifestation for myxedema coma; however, not all bradycardia with hypothyroidism are sinus bradycardia."	2.66	Reversible bradycardia secondary to myxedema coma: case-report. ( Awad, D; Essa, A; Holmberg, M; Kousa, O; Mansour, M; Qasim, A; Sharma, A, 2020)
"Thyroid hormone monitoring and treatment of hypothyroidism is necessary in all patients who have undergone surgical excision of the thyroid gland."	2.66	Severe Hypothyroidism Manifested as Acute Mania With Psychotic Features: A Case Report and Review of the Literature. ( Castro-Revoredo, I; Kaplan, JL, 2020)
"Hypothyroidism is one of the most common disorders encountered in an endocrine office practice."	2.44	Hypothyroidism. ( Burman, KD; Devdhar, M; Ousman, YH, 2007)
"Myxedema coma is the term given to the most severe presentation of profound hypothyroidism and is often fatal in spite of therapy."	2.43	Myxedema coma. ( Wartofsky, L, 2006)
"Hypothyroidism is a common condition presenting a challenge to emergency physicians in diagnosing the underlying etiology of vague complaints."	2.43	Hypothyroidism: mimicker of common complaints. ( Gossain, VV; Shah, SM; Tews, MC, 2005)
"Myxedema coma, the extreme manifestation of hypothyroidism, is an uncommon but potentially lethal condition."	2.41	Myxedema coma: diagnosis and treatment. ( Wall, CR, 2000)
"Myxedema coma is the most severe form of hypothyroidism and is characterized by extreme hypothermia, bradycardia, central hypoventilation and hypoxia."	2.39	[Coma in myxedema--a rare complication of hypothyroidism. Possible iatrogenic factors should be taken into account]. ( Hehrmann, R, 1996)
"Myxedema megacolon is rare; usually, it manifests with abdominal distention, flatulence, and constipation."	2.38	An unusual case of myxedema megacolon with features of ischemic and pseudomembranous colitis. ( Hughes, RW; Patel, R, 1992)
"Endocrine metabolic emergencies are common clinical entities seen by most health care professionals in acute care medicine."	2.37	Endocrine metabolic emergencies. ( Hamburger, SC; Rush, DR, 1984)
"Myxoedema coma is a rare emergency needing prompt recognition and urgent treatment before diagnostic confirmation."	2.36	Myxoedema coma. A review. ( Khaleeli, A, 1978)
"Myxedema coma, neonatal hypothyroidism, primary hypothyroidism, and secondary and tertiary hypothyroidism are specific hypothyroid states for which drug therapy is discussed."	2.36	Drug therapy reviews: management of hypothyroidism. ( Cobb, WE; Jackson, IM, 1978)
"After treatment of hypothyroidism, the thyroid panel, EF, and pericardial effusion improved significantly."	1.91	Large Pericardial Effusion Secondary to Generalized Myxedema from Undiagnosed Hashimoto's Thyroiditis. ( Ashfaq, S; Kilaru, V; Velez-Oquendo, G; Ye, K, 2023)
"In the background of untreated hypothyroidism, a possible association of ovarian hyperstimulation syndrome (OHSS) and reactive pituitary hyperplasia should be kept in mind, thus preventing unnecessary interventions."	1.72	Myxedema crisis and ovarian hyperstimulation in a child with Down syndrome. ( Abraham, MS; Jagannathan, P; Narayanan, R; Sampathkumar, G, 2022)
"While majority of cases have primary hypothyroidism as the underlying aetiology, very few cases have central hypothyroidism."	1.72	Central hypothyroidism with myxoedema: a less known but clinically challenging presentation. ( Batra, N; Kadian, K; Kaur, K; Sridharan, K, 2022)
" This case illustrates some of the challenges associated with the management of patients with signs highly suggestive/diagnostic of myxedema coma, including the optimal loading dosage and intervention timing of thyroid hormone replacement."	1.72	A case of fatal myxedema coma with electrocardiogram Osborne J-wave in a patient initially diagnosed with hypothyroidism. ( Kaneko, M; Ohara, K; Shikata, H, 2022)
"Myxedema coma is a critical disorder with high mortality rates."	1.72	Case Report: Myxedema Coma Caused by Immunoglobulin A Vasculitis in a Patient With Severe Hypothyroidism. ( Akashi, T; Ashida, K; Fukuda, K; Hasuzawa, N; Hayashi, S; Ito, H; Iwata, S; Kabashima, M; Mizuochi, K; Nagayama, A; Nomura, M; Sako, T; Yoshinobu, S, 2022)
"BACKGROUND Myxedema coma is an endocrine emergency with a high mortality rate, defined as a severe hypothyroidism leading to hypotension, bradycardia, decreased mental status, hyponatremia, hypoglycemia, and cardiogenic shock."	1.62	An Unusual Presentation of ST Elevation Myocardial Infarction Complicated with Cardiogenic Shock Due to Myxedema Coma: A Case Report. ( Braiteh, N; Chaudhry, R; Kashou, H; Rahman, MF; Senyondo, GD, 2021)
"Hypothyroidism is a common condition in which the thyroid gland provides insufficient amounts of thyroid hormone for the needs of peripheral tissues."	1.56	Hypothyroidism. ( McDermott, MT, 2020)
"After treatment for myxedema with liothyronine 5 mcg two times per day and levothyroxine 175 mcg once daily via a nasogastric tube and diabetic ketoacidosis with intravenously administered fluid and insulin, his clinical condition rapidly improved including mental status, hyperglycemia, and acidosis."	1.51	Myxedema coma precipitated by diabetic ketoacidosis after total thyroidectomy: a case report. ( Kim, EY; Kim, JJ, 2019)
"Myxedema coma is a rare endocrine emergency resulting from the decompensation of severe hypothyroidism, which is associated with a high mortality rate."	1.51	Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine. ( Kiyota, A; Okazaki, M; Ozaki, N; Tsuchida, M; Ueda, K, 2019)
"Myxedema coma is a serious complication of hypothyroidism that can be precipitated by major surgery."	1.51	Postoperative myxedema coma in patients undergoing major surgery: Case series. ( Abergel, A; Carmel-Neiderman, NN; Fliss, DM; Horowitz, G; Levy, N; Niv, A; Wengier, A; Yafit, D; Yanko-Arzi, R; Zaretski, A, 2019)
"Myxedema is caused by accumulation of glycosaminoglycans in the dermis."	1.48	[A man who was unable to open his eyes]. ( Al Arashi, W; Geijteman, ECT; Schweitzer, DH, 2018)
"Myxoedema coma is a rare, reversible condition with a high mortality and should be considered as a differential diagnosis in medical emergencies."	1.42	Complete recovery after severe myxoedema coma complicated by status epilepticus. ( Fjølner, J; Kampmann, U; Nielsen, S; Søndergaard, E, 2015)
"During admission, the patient developed respiratory failure, renal failure, bleeding symptoms and diffuse colitis."	1.40	Myxoedema coma: an almost forgotten, yet still existing cause of multiorgan failure. ( Feldt-Rasmussen, U; Laursen, AH; Reiter, N; Salomo, LH, 2014)
"Herein we report a rare case of acquired palmoplantar keratoderma in association with myxoedema and hypothyroidism."	1.40	[Palmoplantar keratoderma: a rare manifestation of myxoedema]. ( Addi, H; Benchikhi, H; Bouras, M; Farouki, A; Hali, F; Khadir, K, 2014)
"Myxoedema coma is a rare manifestation of hypothyroidism and it can be lethal if it goes undiagnosed and untreated."	1.40	Postoperative myxoedema coma. ( James, J; James, R; Vij, AS; Vij, KK, 2014)
"Myxedema coma, a rare but fatal emergency, is an extreme expression of hypothyroidism."	1.39	[Myxedema coma in a patient with type 1 neurofibromatosis: rare association]. ( Lalli, CA; Sasazawa, DT; Tsukumo, DM, 2013)
"A 44-year-old male with Graves' disease ongoing for seven years presented bilateral ophthalmopathy and myxoedema of the big toes."	1.39	[Graves' dermopathy on the big toe]. ( Cante, V; Couderc, E; Guillet, G; Renaud, O, 2013)
"Primary hypothyroidism is a common disorder often associated with depression."	1.38	"Myxedema madness" associated with newly diagnosed hypothyroidism and obstructive sleep apnea. ( Neal, JM; Yuhico, RJ, 2012)
"Myxedema coma (MC) is a rare, but often fatal endocrine emergency."	1.37	A case of myxedema coma caused by isolated thyrotropin stimulating hormone deficiency and Hashimoto's thyroiditis. ( Chihara, K; Hino, Y; Iida, K; Ohara, T, 2011)
"Myxedema coma is the extreme form of untreated hypothyroidism."	1.36	A case of myxedema coma presenting as a brain stem infarct in a 74-year-old Korean woman. ( Ahn, HC; Ahn, JY; Kwon, HS; Sohn, YD, 2010)
"We report myxedema coma, an emergency condition caused by severe hypothyroidism, after a patient underwent esophagectomy for esophageal cancer."	1.36	Myxedema coma after esophagectomy. ( Hu, Y; Xie, T; Yuan, Y; Zhao, Y, 2010)
"Hormonal laboratory data showed severe primary hypothyroidism with a serum TSH of 594 IU/L and a free thyroxin level of 0."	1.34	Myxedema ascites with an extremely elevated CA125 Level: a case report. ( Bando, Y; Kanehara, H; Kontani, M; Takegoshi, Y; Tanaka, N; Tomita, M, 2007)
"The patients in coma at entry had significantly higher mortality rates than those with minor degrees of consciousness (75% vs 14."	1.32	Factors associated with mortality of patients with myxoedema coma: prospective study in 11 cases treated in a single institution. ( Fluiters, E; García-Mayor, RV; Luna, R; Páramo, C; Pérez-Méndez, LF; Rodríguez, I, 2004)
"Pericardial effusion is frequently found in patients diagnosed with hypothyroidism, yet it is rarely associated with cardiac tamponade."	1.32	Myxedema associated with cardiac tamponade. ( Chen, BC; Chen, CW; Lin, CL; Lin, CT; Lin, TK; Liu, CJ, 2003)
"Myxedema coma develops as a consequence of severe hypothyroidism and is characterized by a hypometabolic, stuporous state."	1.31	Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog. ( Dixon, RM; Henik, RA, 2000)
"Myxedema coma is a rare, often fatal endocrine emergency that concerns elderly patients with long-standing primary hypothyroidism; myxedema coma of central origin is exceedingly rare."	1.31	Myxedema coma of both primary and secondary origin, with non-classic presentation and extremely elevated creatine kinase. ( Arrigo, F; Benvenga, S; Cimino, A; Saporito, F; Squadrito, S; Trimarchi, F, 2000)
"Myxedema is the cause of ascites in less than 1% of new-onset ascites cases, where as only 4% of patients with hypothyroidism present ascites."	1.31	Ascites due to hypothyroidism in a patient with alcoholic cirrhosis. ( Corino, M; Fassio, E; Landeira, G; Otero Bedoya, J; Tamashiro, A, 2001)
"Hypothyroidism is a commonly diagnosed endocrine disorder."	1.30	Unusual presentations of hypothyroidism. ( Westphal, SA, 1997)
"Hypothyroidism is an endocrine condition found in elderly patients that is often confused with normal changes associated with aging."	1.30	Hypothyroidism in elderly patients. ( Bailes, BK, 1999)
"A 46-year-old woman with hypothyroid Graves' disease (EMO syndrome) is reported."	1.29	Successful treatment of hypothyroid Graves' disease with a combination of levothyroxine replacement, intravenous high-dose steroid and irradiation to the orbit. ( Fujiwara, K; Hayakawa, K; Koh, T; Koshiyama, H; Mori, S, 1993)
"The association between myxedema coma and triphasic waves has not been previously reported."	1.29	Triphasic waves in myxedema coma. ( River, Y; Zelig, O, 1993)
"We conclude that hypothyroidism affects respiratory muscle strength and that this weakness is linearly related to thyroid hormone levels."	1.28	Respiratory muscle strength in hypothyroidism. ( Bouros, D; Filaditaki, V; Salesiotou, V; Siafakas, NM; Thalassinos, N; Tzanakis, N, 1992)
"Cortisone therapy was used in 3 patients."	1.28	Myxoedema coma: response of thyroid hormones with oral and intravenous high-dose L-thyroxine treatment. ( Arlot, S; Debussche, X; Fournier, A; Lalau, JD; Mesmacque, A; Quichaud, J; Tolani, M, 1991)
"Amiodarone is a potent new antiarrhythmic drug that has multiple effects on thyroid function, including inhibition of extrathyroidal triiodothyronine production and rarely, iodine-induced hypothyroidism."	1.27	Myxedema coma during long-term amiodarone therapy. ( Cantley, LK; Dalldorf, FG; Foster, JR; Mazonson, PD; Utiger, RD; Williams, ML, 1984)
"Treatment of myxoedema coma has been associated with a high mortality."	1.27	Treatment of myxoedema coma--factors associated with fatal outcome. ( Hylander, B; Rosenqvist, U, 1985)
"Myxedema coma is an endocrine emergency that requires prompt treatment of both the metabolic complications and any intercurrent illness."	1.27	Adult hypothyroidism. 2. Causes, laboratory diagnosis, and treatment. ( Mazzaferri, EL, 1986)
"The personality disorders were a major problem in the patient's medical and psychiatric care."	1.27	The diagnostic dilemma of myxedema and madness, axis I and axis II: a longitudinal case report. ( Darko, DF; Dickinson, M; Gillin, JC; Krull, A; Risch, SC, 1988)
"Eight cases of hypothyroid coma observed between 1971 and 1981 are reported, and their main clinical, biological and therapeutic features described."	1.27	[Myxedema coma. Apropos of 8 cases]. ( Charbonnel, B; de Rostu, H; Desjars, P, 1983)
"Pretibial myxedema is typically associated with clinical hyperthyroidism, diffuse goiter, and ophthalmopathy in patients with Graves' disease."	1.27	Euthyroid pretibial myxedema. ( Chen, JJ; Ladenson, PW, 1987)
"A case of myxoedema coma in which the serum sodium level dropped precipitously when therapy was started is described and it is suggested that this was due to a state of relative hypocortisolism."	1.27	Hyponatraemia complicating the treatment of myxoedema coma. A case report. ( Berkowitz, I; Di Bisceglie, AM, 1986)
"Generalized convulsions were particularly common, occuring in five patients."	1.26	Unusual presentation of myxoedema coma in the elderly. ( Impallomeni, MG, 1977)
"A 45-year-old woman with myxedema coma due to primary hypothyroidism manifested hyponatremia, impaired water excretion, and elevated urine osmolarity as well as natriuresis suggestive of a syndrome of inappropriate antidiuretic hormone secretion."	1.26	Hyponatremia without inappropriate secretion of vasopressin in a case of myxedema coma. ( Kimura, S; Koide, Y; Maruyama, M; Nabeshima, I; Oda, K; Shimizu, A; Shimizu, K; Yamashita, K, 1982)
"In patients with Graves' disease there was no correlation between the level of TSAb and hormonal status except serum triiodothyronine (rs = 0."	1.26	Thyroid adenylate cyclase stimulating immunoglobulins in thyroid diseases. ( Bech, K; Nistrup Madsen, S, 1979)
"Myxoedema coma is fortunately rare and is probably rarer in a warm climate such as Australia."	1.26	A case of myxoedema coma successfully treated by low dose oral triiodothyronine. ( Graham, JJ; Harding, PE, 1977)
"Furthermore in Graves' disease progression of exophthalmos has sometimes been seen following thyroidectomy."	1.26	Serum thyroglobulin and its autoantibody following subtotal thyroid resection of Graves' disease. ( Blichert-Toft, M; Christiansen, C; Date, J; Feldt-Rasmussen, U, 1982)
"A 35-year-old patient with Sheehan's syndrome presented with hypothyroidism and hypo-adrenalism despite having received treatment with regular daily L-thyroxine (0,3 mg) and prednisone (30 mg) for the preceding 12 months."	1.26	Sheehan's syndrome presenting with hypothyroidism and hypo-adrenalism despite treatment with thyroxine and prednisone. ( Asmal, AC; Dayal, B; Leary, WP; Winning, T, 1978)
"Alveolar hypoventilation is known to occur in myxedema."	1.25	Ventilatory control in myxedema and hypothyroidism. ( Hofeldt, FD; Lufkin, EG; Pierson, DJ; Weil, JV; Zwillich, CW, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	321 (71.81)	18.7374
1990's	29 (6.49)	18.2507
2000's	37 (8.28)	29.6817
2010's	42 (9.40)	24.3611
2020's	18 (4.03)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Desiccated Thyroid Extract Compared to Levothyroxine in the Treatment of Hypothyroidism: A Randomized, Double-blind, Crossover Study.[NCT01739972]				180 participants (Anticipated)	Interventional	2012-05-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Myxedema coma following rifampicin - A clinical case and literature review. Annales d'endocrinologie, 2023, Volume: 84, Issue:1 Topics: Coma; Humans; Myxedema; Rifampin; Thyroxine	2023
Reversible bradycardia secondary to myxedema coma: case-report. Reviews in cardiovascular medicine, 2020, Jun-30, Volume: 21, Issue:2 Topics: Aged, 80 and over; Bradycardia; Cardiac Pacing, Artificial; Coma; Female; Heart Rate; Hormone Replac	2020
Severe Hypothyroidism Manifested as Acute Mania With Psychotic Features: A Case Report and Review of the Literature. Journal of psychiatric practice, 2020, Volume: 26, Issue:5 Topics: Adult; Antipsychotic Agents; Female; Humans; Hypothyroidism; Mania; Myxedema; Psychotic Disorders; T	2020
Laryngeal myxoedema: a literature review of an uncommon complication of hypothyroidism. BMJ case reports, 2021, Apr-01, Volume: 14, Issue:4 Topics: Female; Humans; Hypothyroidism; Larynx; Middle Aged; Myxedema; Thyroxine; Tracheostomy	2021
PHYSIOLOGIC EFFECTS OF THYROXINE IN MAN. Mayo Clinic proceedings, 1964, Volume: 39 Topics: Blood; Body Fluids; Calcium; Congenital Hypothyroidism; Drug Therapy; Hyperthyroidism; Hypothyroidis	1964
Hypothyroidism: mimicker of common complaints. Emergency medicine clinics of North America, 2005, Volume: 23, Issue:3 Topics: Diagnosis, Differential; Emergency Service, Hospital; Female; Humans; Hypothyroidism; Male; Middle A	2005
Myxedema coma. Endocrinology and metabolism clinics of North America, 2006, Volume: 35, Issue:4 Topics: Aged; Coma; Female; Glucocorticoids; Humans; Hyponatremia; Hypotension; Hypothermia; Male; Myxedema;	2006
Hypothyroidism. Endocrinology and metabolism clinics of North America, 2007, Volume: 36, Issue:3 Topics: Coma; Drug Therapy, Combination; Female; Humans; Hypothyroidism; Myxedema; Pregnancy; Pregnancy Comp	2007
Hypothyroidism and myxedema coma. Compendium (Yardley, PA), 2007, Volume: 29, Issue:1 Topics: Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Hypothyroidism; Myxedema; Thyroid Function Tests; T	2007
[Metabolic pericarditis (uremia, myxedema)]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Sep-28, Volume: Suppl 5 Pt 2 Topics: Acute Disease; Cardiac Tamponade; Diagnosis, Differential; Dialysis; Humans; Hypothyroidism; Myxedem	2007
Endocrine metabolic emergencies. Southern medical journal, 1984, Volume: 77, Issue:2 Topics: Adrenal Insufficiency; Coma; Critical Care; Diabetic Coma; Diabetic Ketoacidosis; Electrolytes; Emer	1984
Hypothyroidism in the elderly. Comprehensive therapy, 1984, Volume: 10, Issue:4 Topics: Aged; Aging; Anemia; Arrhythmias, Cardiac; Carcinoembryonic Antigen; Creatine Kinase; Diagnosis, Dif	1984
[Emergency therapy in endocrine crises]. Die Medizinische Welt, 1980, Jan-18, Volume: 31, Issue:3 Topics: Addison Disease; Calcitonin; Digitalis Glycosides; Dopamine; Emergencies; Humans; Hydrocortisone; Hy	1980
[Coma in myxedema--a rare complication of hypothyroidism. Possible iatrogenic factors should be taken into account]. Fortschritte der Medizin, 1996, Dec-10, Volume: 114, Issue:34 Topics: Coma; Humans; Hypothyroidism; Iatrogenic Disease; Myxedema; Prognosis; Thyrotropin; Thyroxine	1996
Factors associated with mortality of myxedema coma: report of eight cases and literature survey. Thyroid : official journal of the American Thyroid Association, 1999, Volume: 9, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Coma; Dose-Response Relationship, Drug; Female; Humans; Injections,	1999
Myxedema coma: diagnosis and treatment. American family physician, 2000, Dec-01, Volume: 62, Issue:11 Topics: Coma; Diagnosis, Differential; Humans; Infusions, Intravenous; Myxedema; Prognosis; Risk Factors; Th	2000
The diagnosis and management of hypothyroidism. Southern medical journal, 2002, Volume: 95, Issue:5 Topics: Coma; Humans; Hypothyroidism; Myxedema; Thyroid Function Tests; Thyroxine	2002
Drug therapy reviews: management of hypothyroidism. American journal of hospital pharmacy, 1978, Volume: 35, Issue:1 Topics: Autoimmune Diseases; Coma; Humans; Hyperthyroidism; Hypothyroidism; Infant, Newborn; Infant, Newborn	1978
Myxoedema coma. A review. Pahlavi medical journal, 1978, Volume: 9, Issue:2 Topics: Acute Kidney Injury; Coma; Diagnosis, Differential; Hemorrhage; Humans; Hypoglycemia; Hyponatremia;	1978
Atherosclerosis, hypothyroidism, and thyroid hormone therapy. Advances in lipid research, 1978, Volume: 16 Topics: Arteriosclerosis; Female; Genital Diseases, Female; Heart Diseases; Humans; Hypercholesterolemia; Hy	1978
Investigation and treatment of hypothyroidism. Clinics in endocrinology and metabolism, 1979, Volume: 8, Issue:1 Topics: Adult; Coma; Goiter, Endemic; Humans; Hypothyroidism; Middle Aged; Myxedema; Thyroid Function Tests;	1979
An unusual case of myxedema megacolon with features of ischemic and pseudomembranous colitis. Mayo Clinic proceedings, 1992, Volume: 67, Issue:4 Topics: Aged; Colitis; Colon; Enterocolitis, Pseudomembranous; Humans; Ischemia; Male; Megacolon; Myxedema;	1992
Myxedema ascites. Report of two cases and review of the literature. Journal of clinical gastroenterology, 1991, Volume: 13, Issue:4 Topics: Adult; Ascites; Ascitic Fluid; Female; Humans; Male; Middle Aged; Myxedema; Proteins; Thyroid Functi	1991
Sleep apnea and hypothyroidism. Southern medical journal, 1988, Volume: 81, Issue:11 Topics: Humans; Hypothyroidism; Myxedema; Obesity; Positive-Pressure Respiration; Sleep Apnea Syndromes; Thy	1988
Lumbar spine bone mineral content by photon beam absorptiometry. Methodology and application in osteoporosis. Danish medical bulletin, 1985, Volume: 32, Issue:3 Topics: Aging; Female; Fractures, Bone; Humans; Hyperthyroidism; Lumbar Vertebrae; Menopause; Methods; Miner	1985
Sex-hormone-binding globulin. Clinical endocrinology, 1974, Volume: 3, Issue:1 Topics: Adolescent; Androgen-Insensitivity Syndrome; Beta-Globulins; Carrier Proteins; Estradiol; Estrogens;	1974
Myxoedema. The Practitioner, 1972, Volume: 208, Issue:245 Topics: Anemia; Blood Coagulation Disorders; Central Nervous System Diseases; Electrocardiography; Female; G	1972
Myxedema coma. The American journal of the medical sciences, 1972, Volume: 264, Issue:6 Topics: Adrenal Glands; Cachexia; Central Nervous System; Coma; Heart Diseases; Humans; Hypoglycemia; Hypona	1972
Cretinism and the fetal-maternal relationship. Advances in experimental medicine and biology, 1972, Volume: 30 Topics: Animals; Bone and Bones; Congenital Hypothyroidism; Female; Humans; Hypothyroidism; Iodine; Maternal	1972
Lipid changes in thyroid disease: the effect of thyroxine and analogues. Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:7 Topics: Animals; Cholesterol; Humans; Hypercholesterolemia; Hyperthyroidism; In Vitro Techniques; Lipid Meta	1974
[The clinical picture and therapy of Sheehan's syndrome (author's transl)]. Wiener klinische Wochenschrift, 1974, Sep-20, Volume: 86, Issue:17 Topics: Addison Disease; Amenorrhea; Anorexia Nervosa; Celiac Disease; Cortisone; Diagnosis, Differential; F	1974
Guidelines for the treatment of myxedema. The Medical clinics of North America, 1968, Volume: 52, Issue:2 Topics: Adult; Basal Metabolism; Blood Proteins; Child, Preschool; Coma; Female; Humans; Myxedema; Nephrotic	1968
[Treatment of myxedema]. Saishin igaku. Modern medicine, 1970, Volume: 25, Issue:3 Topics: Diuretics; Heart Diseases; Humans; Myxedema; Thyroid Diseases; Thyroid Hormones; Thyronines; Thyroxi	1970

Article	Year
Evaluation of a simplified technique for the specific measurement of serum thyroxine concentration. The Journal of clinical endocrinology and metabolism, 1971, Volume: 32, Issue:4 Topics: Alpha-Globulins; Chemistry, Clinical; Chromatography, Gel; Clinical Trials as Topic; Female; Humans;	1971
Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide. Biochemical and biophysical research communications, 1971, Volume: 45, Issue:4 Topics: Adult; Aged; Clinical Trials as Topic; Female; Follicle Stimulating Hormone; Goiter; Humans; Hyperth	1971

thyroxine and Myxedema

Research Excerpts

Research

Studies (447)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Abraham, MS	1
Sampathkumar, G	1
Narayanan, R	1
Jagannathan, P	1
Tng, EL	1
Aung, AT	1
Chong, N	1
Ito, H	1
Fukuda, K	1
Ashida, K	1
Nagayama, A	1
Sako, T	1
Mizuochi, K	1
Kabashima, M	1
Yoshinobu, S	1
Iwata, S	1
Hasuzawa, N	1
Hayashi, S	1
Akashi, T	1
Nomura, M	1
Kaneko, M	1
Ohara, K	1
Shikata, H	1
Chaudhary, S	1
Das, L	1
Sharma, N	2
Sachdeva, N	1
Bhansali, A	2
Dutta, P	3
Kaur, K	1
Kadian, K	1
Batra, N	1
Sridharan, K	1
Chan, EC	1
Saraiva, M	1
Maia, A	1
Assunção, G	1
Freitas, C	1
Couto de Carvalho, A	1
Sokołowski, G	1
Motyka, M	1
Gilis-Januszewska, A	1
Stefańska, A	1
Hubalewska-Dydejczyk, A	1
Velez-Oquendo, G	1
Kilaru, V	1
Ye, K	1
Ashfaq, S	1
Kew, JL	1
Bain, SC	1
McDermott, MT	1
Kousa, O	1
Mansour, M	1
Awad, D	1
Essa, A	1
Qasim, A	1
Sharma, A	2
Holmberg, M	1
Kaplan, JL	1
Castro-Revoredo, I	1
Renne, SL	1
Valeri, M	1
Radaelli, S	1
Collini, P	1
Barisella, M	1
Braiteh, N	1
Senyondo, GD	1
Rahman, MF	1
Chaudhry, R	1
Kashou, H	1
Iftikhar, MH	1
Raziq, FI	1
Coll, P	1
Dar, AY	1
Hariharan, R	1
Maulik, K	1
Karunakar, P	1
Parameswaran, N	1
Gunasekaran, D	1
Jose, D	1
Rajavelu, TN	1
Akshaykumar, R	1
Wang, YN	1
Wang, T	1
Ma, DL	1
Li, L	1
Al Arashi, W	1
Geijteman, ECT	1
Schweitzer, DH	1
Singla, M	1
Gupta, A	2
Yafit, D	1
Carmel-Neiderman, NN	1
Levy, N	1
Abergel, A	1
Niv, A	1
Yanko-Arzi, R	1
Zaretski, A	1
Wengier, A	1
Fliss, DM	1
Horowitz, G	1
Kim, JJ	1
Kim, EY	1
Ueda, K	1
Kiyota, A	1
Tsuchida, M	1
Okazaki, M	1
Ozaki, N	1
Kumar, A	1
Agarwal, A	1
Agarwal, D	1
Jain, N	1
Gupta, P	1
Redkar, N	1
Bendle, M	1
Maidapwad, V	1
Chavan, R	1
Shriwastav, R	1
Couderc, E	1
Cante, V	1
Renaud, O	1
Guillet, G	1
Chaudhari, D	1
Gangadharan, V	1
Forrest, T	1
Gupta, KJ	1
Sasazawa, DT	1
Tsukumo, DM	1
Lalli, CA	1
Bouras, M	1
Hali, F	1
Khadir, K	1
Addi, H	1
Farouki, A	1
Benchikhi, H	1
Salomo, LH	1
Laursen, AH	1
Reiter, N	1
Feldt-Rasmussen, U	2
James, R	1
James, J	1
Vij, AS	1
Vij, KK	1
Bajaj, R	1
Mehrzad, R	1
Singh, K	1
Gupta, JP	1
Iovino, M	1
Iovine, N	1
Petrosino, A	1
Giagulli, VA	1
Licchelli, B	1
Guastamacchia, E	1
Triggiani, V	1
Vargas, N	1
Tibullo, L	1
Carifi, S	1
Cucciniello, A	1
Landi, E	1
Barbella, MR	1
Di Grezia, F	1
Kim, J	1
Fjølner, J	1
Søndergaard, E	1
Kampmann, U	1
Nielsen, S	1
Sendhil Kumaran, M	1
Sakia, U	1
Dogra, S	1
Morosán Allo, YJ	1
Rosmarin, M	1
Urrutia, A	1
Faingold, MC	1
Musso, C	1
Brenta, G	1
Madan, N	1
Tiwari, N	1
Stampfer, M	1
Schubart, U	1
Spyridoulias, A	1
Riaz, MS	1
Gish, DS	1
Loynd, RT	1
Melnick, S	1
Nazir, S	1
Shlykov, MA	1
Rath, S	1
Badger, A	1
Winder, GS	1
Bastiampillai, T	1
Disha, TI	1
Lam, DH	1
Khan, U	1
Rizvi, H	1
Sano, D	1
Chiu, J	1
Hadid, T	1
Juarez, M	1
Rohloff, P	1
Hunzeker, CM	1
Kamino, H	1
Walters, RF	1
Kovich, OI	1
González Castro, AM	1
López Piñeiro, S	1
Moreno López, E	1
Rodríguez Losada, M	1
Rodríguez-Garrocho, A	1
Jover-Sáenz, A	1
Barcenilla-Gaite, F	1
Porcel-Pérez, JM	1
Kovács, V	1
Teymoortash, A	1
Werner, JA	1
Lichtenberger, G	1
Flood, JA	1
Hoover, JP	1
Moeller, KE	1
Goswami, R	1
Larsen, LM	1
Chung, A	1
Yuan, Y	1
Hu, Y	1
Xie, T	1
Zhao, Y	1
Ahn, JY	1
Kwon, HS	1
Ahn, HC	1
Sohn, YD	1
Karmisholt, J	1
Andersen, S	1
Laurberg, P	3
Iida, K	1
Hino, Y	1
Ohara, T	1
Chihara, K	1
G Pearse, S	1
D Dahdal, M	1
Grocott-Mason, R	1
W Dubrey, S	1
Barbetakis, N	1
Asteriou, C	1
Tsilikas, C	1
Vitale, J	1
Fesce, E	1
Schmidt, G	1
Kamath, C	1
Young, S	1
Kabelis, K	1
Sanders, J	1
Adlan, MA	1
Furmaniak, J	1
Rees Smith, B	1
Premawardhana, LD	1
Neal, JM	1
Yuhico, RJ	1
Kasherman, L	1
Foy, A	2
Tierney, A	1
Reeves, GE	1
Tran, HA	2
García Gil, ME	1
Vales, GJ	1
Kollmar, R	1
Schellinger, PD	1
Bardutzky, J	1
Meisel, F	1
Schwaninger, M	1
Lin, CT	1
Liu, CJ	1
Lin, TK	1
Chen, CW	1
Chen, BC	1
Lin, CL	1
Rotman-Pikielny, P	1
Brucker-Davis, F	1
Turner, ML	1
Sarlis, NJ	1
Skarulis, MC	1
SALTER, WT	1
ROSENBLUM, I	1
PAPPER, S	1
BURROWS, BA	1
INGBAR, SH	6
SISSON, JH	1
ROSS, JF	1
MAHAUX, J	1
KOIW, E	1
RAWSON, RV	1
RALL, JE	4
PEARSON, OH	2
ROBBINS, J	3
POPPELL, HF	2
WEST, CD	2
DELTOUR, G	1
BEKAERT, J	1
ASPER, SP	2
SELENKOW, HA	2
PLAMONDON, CA	1
LERMAN, J	2
LEDERER, J	1
TUSQUES, J	1
RAWSON, RW	3
BLACKBURN, CM	1
McCONAHEY, WM	1
KEATING, FR	1
ALBERT, A	2
LORENZINI, P	1
LUND, E	1
BEIERWALTES, WH	1
BISHOP, RC	1
SCHULTZ, AL	1
SANDHAUS, S	1
DEMOREST, HL	1
ZIEVE, L	1
COMPSTON, N	1
PITT-RIVERS, R	1
FRAWLEY, TF	1
MCCLINTOCK, JC	1
BEEBE, RT	1
MARTHY, GL	1
CRISPELL, KR	1
PARSON, W	1
HOLLIFIELD, G	1
VILLALBA GONZALEZ, A	1
CERVINO, JM	1
RAVERA, JJ	1
RAWAK, F	1
ALBRIEUX, AS	1
MUSSIO-FOURNIER, JC	1
MCGAVACK, TH	1
RECKENDORF, HK	1
DUMOVIC, B	1
NEDELJKOVIC, S	1
STERLING, K	2
CHODOS, RB	1
LANGANKE, E	1
BARAC, G	1
BEECKMANS, G	1
FRIIS, T	2
IVERSEN, K	1
KYLE, LH	1
CANARY, JJ	1
MEYER, RJ	1
PAC, FP	1
LEWALLEN, CG	1
BERMAN, M	1
MORNEX, R	1
PEYRIN, JO	1
POMMATAU, E	1
BERGER, M	1
RIFFAT, G	1
BENUA, RS	1
LEEPER, RD	1
KUMAOKA, S	1
STARR, P	3
BEST, MM	1
DUNCAN, CH	1
PINCHERA, A	2
MENZINGER, G	1
BELLABARBA, D	1
GRECO V BASCHIERI, L	1
LISSITZKY, S	1
SCHWARZ, K	1
HOLVEY, DN	1
GOODNER, CJ	1
NICOLOFF, JT	2
DOWLING, JT	3
VERBOV, JL	1
RUNYAN, JW	1
LAVIETES, PH	1
EPSTEIN, FH	1
LESSOF, MH	2
TRAFFORD, JA	1
SPENCE, AW	1
CODACCIONI, JL	1
SZANTO, L	2
KATONA, M	1
GOERGENYI, F	1
REVICZKY, A	2
DIMITRIADOU, A	1
FRASER, R	1
TURNER, PC	1
MAHOUDEAU, D	1
POYART, C	1
BANTMAN, C	1
FERREY, A	1
BAUMANN, J	1
DUNN, JT	1
WERNER, SC	1
HAMOLSKY, MW	1
BROUHON-MASSILLON, L	1
BELLAU, AR	1
TONKS, CM	1
SCHNEEBERG, NG	1
MITCHELL, ML	1
BRADFORD, AH	1
COLLINS, S	1
CAMPBELL, A	1
CAMERON, E	1
MOLLISON, A	1
WEST, ED	1
WALTER, CJ	1
Pettinger, WA	1
Talner, L	1
Ferris, TF	1
DANOWSKI, TS	1
MOSES, C	1
KURTZMAN, RS	1
OTTO, DL	1
CHEPEY, JJ	1
IVY, HK	1
LOCKETT, MF	1
NAIL, B	1
MARTIN, L	1
SPATHIS, GS	1
ZONDEK, H	1
LESZYNSKY, HE	1
ZONDEK, GW	1
LEIBHOLD-SCHUECK, R	1
YOUNG, FR	1
TAPLEY, DF	1
NEIMANN, N	1
MICHEL, R	1
PIERSON, M	1
MARTIN, J	1
GUERCI, O	1
MERCENIER, R	1
Rodríguez, I	1
Fluiters, E	1
Pérez-Méndez, LF	1
Luna, R	1
Páramo, C	1
García-Mayor, RV	1
HART, FD	1
MACLAGAN, NF	2
OWREN, PA	1
HALMI, NS	1
ROBERTSON, JD	1
KIRKPATRICK, HF	1
MORTARA, M	1
BJERKELUND, CJ	1
Frost, N	1
Lee, MS	1
Sweeney, P	1
Tews, MC	1
Shah, SM	1
Gossain, VV	1
Duarte, DR	1
Chang, CV	1
Minicucci, MF	1
Zornoff, LA	1
Inoue, RM	1
Matsui, M	1
Okoshi, MP	1
Azevedo, PS	1
Matsubara, LS	1
Paiva, SA	1
Schenck, JB	1
Rizvi, AA	1
Lin, T	1
Jansen, HJ	1
Doebé, SR	1
Louwerse, ES	1
van der Linden, JC	1
Netten, PM	1
Bilen, H	1
Atasoy, M	1
Akcay, G	1
Akcay, M	1
Capoglu, I	1
Gursan, N	1
Akbas, M	1
Fischli, S	1
Stettler, C	1
Christ, E	1
Wartofsky, L	3
Sheu, CC	1
Cheng, MH	1
Tsai, JR	1
Hwang, JJ	1
Hsu, YF	1
Huang, YK	1
Lu, MS	1
Tseng, CN	1
Tsai, FC	1
Lin, PJ	1
Kanehara, H	1
Bando, Y	1
Tomita, M	1
Kontani, M	1
Takegoshi, Y	1
Tanaka, N	1
Devdhar, M	1
Ousman, YH	1
Burman, KD	3
Finora, K	1
Greco, D	1
Katoh, S	1
Sutani, Y	1
Masoodi, SR	1
Bhadada, S	1
Rajput, R	1
Taguchi, T	1
Iwasaki, Y	1
Asaba, K	1
Takao, T	1
Hashimoto, K	1
Beynon, J	1
Akhtar, S	1
Kearney, T	1
Bonnyns, M	2
Bastenie, PA	1
Ward, DJ	1
Rastall, ML	1
Menon, IS	1
Lloyd, WH	1
Mawdsley, C	1
Siersbaek-Nielsen, K	6
Hansen, JM	6
James, JA	1
Weeke, J	3
Christensen, SE	1
Hansen, AP	1
Lundbaek, K	1
Burr, WA	2
Ramsden, DB	2
Hoffenberg, R	2
Bentin, J	1
Devetter, G	1
Duchateau, J	1
Guerin, JM	1
Tibourtine, O	1
Segrestaa, JM	2
Rush, DR	1
Hamburger, SC	1
Davis, PJ	1
Davis, FB	1
Winkelmann, W	1
Mazonson, PD	1
Williams, ML	1
Cantley, LK	1
Dalldorf, FG	1
Utiger, RD	1
Foster, JR	1
Mackay, D	1
Cooper, RA	1
Bradbury, S	1
Gawkrodger, DJ	1
Prowse, K	1
Van't Hoff, W	2
Chen, YY	1
Krølner, B	2
Jørgensen, JV	1
Nielsen, SP	1
Arvan, S	1
Biswas, SK	1
Ghose, JC	1
Desjars, P	1
de Rostu, H	1
Charbonnel, B	1
Trimarchi, F	2
Benvenga, S	2
Costante, G	1
Barbera, C	1
Melluso, R	1
Marcocci, C	2
Chiovato, L	2
De Luca, F	1
Consolo, F	1
Yamaguchi, K	1
Fukushima, H	1
Uzawa, H	1
Iseki, T	1
Shiroozu, A	1
Inoue, K	1
Blichert-Toft, M	1
Christiansen, C	1
Date, J	1
Chernow, B	1
Johnson, DL	1
McGuire, RA	1
O'Brian, JT	1
Georges, LP	1
Hùdepohl, M	1
Lever, EG	1
Smekens, L	1
Golstein, J	1
Vanhaelst, L	1
Harayama, H	1
Ohno, T	1
Miyatake, T	1
Urdahl, P	1
Felstein, I	1
Jakubovic, HR	1
Salama, SS	1
Rosenthal, D	1
Georgitis, WJ	1
Hofeldt, FD	2
Paggi, A	2
Cassone, R	1
Lucisano, V	1
Chieco, P	1
Dalmaso, S	1
Danese, V	1
Corsi, V	1
Nielsen, SL	2
Parving, HH	3
Hansen, JE	1
Ladenson, PW	2
Goldenheim, PD	1
Cooper, DS	1
Miller, MA	1
Ridgway, EC	2
Das, S	1
Lieberman, AN	1
Schussler, GC	2
Desai, SG	1
Wali, GM	1
Khaleeli, AA	1
Memon, N	1
Koide, Y	1
Oda, K	1
Shimizu, K	1
Shimizu, A	1
Nabeshima, I	1
Kimura, S	1
Maruyama, M	1
Yamashita, K	1
Crotty, CP	1
Dicken, CH	1
McGaffee, J	1
Barnes, MA	1
Lippmann, S	1
Orr, WC	1
Males, JL	1
Imes, NK	1
Niimi, H	2
Sasaki, N	2
Inomata, H	2
Nakajima, H	2
Brown, ME	1
Refetoff, S	1
Hylander, B	2
Norée, LO	1
Rosenqvist, U	2
Sjöberg, HE	1
Límanová, Z	1
Hradec, J	1
Easson, WM	1
Bacci, V	1
Bhogal, RS	1
Carter, AC	1
Pittman, CS	1
Brown, RS	1
Bellisario, RL	1
Mitchell, E	1
Keating, P	1
Botero, D	1
Peter, SA	1
Brignol, YF	1
Koshiyama, H	1
Mori, S	1
Fujiwara, K	1
Hayakawa, K	1
Koh, T	1
River, Y	1
Zelig, O	1
Mantzoros, CS	1
Ravi, J	1
Hall, C	1
Batch, J	1
Jones, C	1
Sato, K	1
Miyakawa, M	1
Demura, H	1
McMorrow, ME	1
Depczynski, B	1
Ward, R	1
Eisman, J	1
Hehrmann, R	1
Westphal, SA	1
Song, SH	1
McCallum, CJ	1
Campbell, IW	1
Bailes, BK	1
Villabona, C	1
Sahun, M	1
Roca, M	1
Mora, J	1
Gómez, N	1
Gómez, JM	1
Puchal, R	1
Soler, J	1
Corbalán-Vélez, R	1
Pérez-Ferriols, A	1
Aliaga-Bouiche, A	1
Yamamoto, T	1
Fukuyama, J	1
Fujiyoshi, A	1
Henik, RA	1
Dixon, RM	1
Squadrito, S	1
Saporito, F	1
Cimino, A	1
Arrigo, F	1
Wall, CR	1
Orija, IB	1
Cohen, SB	1
Sutor, GC	1
Klocke, M	1
Hamm, M	1
Fabel, H	1
Schuppert, F	1
Otero Bedoya, J	1
Landeira, G	1
Corino, M	1
Tamashiro, A	1
Fassio, E	1
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Chang, YS	1
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Krishnaswamy, G	1
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Kacalak-Rzepka, A	1
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