thyroxine has been researched along with Myocardial Ischemia in 25 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In some patients with severe hypothyroidism thyroxine replacement therapy precipitates or aggravates angina pectoris, whereas in other patients angina pectoris is ameliorated or even disappears." | 5.08 | Silent myocardial ischemia in hypothyroidism. ( Bernstein, R; Haug, E; Hertzenberg, L; Midtbø, K; Müller, C; Smith, G, 1995) |
| "The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period." | 3.88 | IMPORTANCE OF ISOLATED GESTATIONAL HYPOTHYROXINEMIA IN THE DEVELOPMENT OF OBSTETRIC AND SOMATIC PATHOLOGIES. ( Gagua, D; Gagua, T; Morchiladze, N; Tkeshelashvili, B, 2018) |
| "Two cases of hypothyroidism with cardiac attack (acute myocardial infarction, AMI) following thyroxine replacement were reported." | 3.71 | Severe myocardial ischemia following hormone replacement in two cases of hypothyroidism with normal coronary arteriogram. ( Hara, Y; Kohno, A, 2001) |
| "Myocardial ischemia was revealed in 1 patient but was seen in both hypothyroid and euthyroid examinations." | 1.30 | Severe short-term hypothyroidism is not associated with an increased incidence of myocardial ischemia as assessed by thallium-201 stress/rest myocardial scintigraphy. ( Dudczak, R; Holm, C; Hurtl, I; Najemnik, C; Prasch, F; Wogritsch, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 11 (44.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alonso-Ventura, V | 1 |
| Civeira, F | 1 |
| Alvarado-Rosas, A | 1 |
| Lou-Bonafonte, JM | 1 |
| Calmarza, P | 1 |
| Moreno-Franco, B | 1 |
| Andres-Otero, MJ | 1 |
| Calvo-Gracia, F | 1 |
| de Diego-Garcia, P | 1 |
| Laclaustra, M | 1 |
| Zhang, H | 1 |
| Che, W | 1 |
| Shi, K | 1 |
| Huang, Y | 1 |
| Xu, C | 1 |
| Fei, M | 1 |
| Fan, X | 1 |
| Zhang, J | 1 |
| Hu, X | 1 |
| Hu, F | 1 |
| Qin, S | 1 |
| Zhang, X | 1 |
| Huang, Q | 1 |
| Yu, F | 1 |
| Müller, P | 1 |
| Dietrich, JW | 1 |
| Lin, T | 1 |
| Bejinariu, A | 1 |
| Binnebößel, S | 1 |
| Bergen, F | 1 |
| Schmidt, J | 1 |
| Müller, SK | 1 |
| Chatzitomaris, A | 1 |
| Kurt, M | 1 |
| Gerguri, S | 1 |
| Clasen, L | 1 |
| Klein, HH | 1 |
| Kelm, M | 1 |
| Makimoto, H | 1 |
| Zhao, JV | 1 |
| Schooling, CM | 1 |
| Morchiladze, N | 1 |
| Tkeshelashvili, B | 1 |
| Gagua, T | 1 |
| Gagua, D | 1 |
| Mustafa, C | 1 |
| Ozgül, U | 1 |
| Zehra, GC | 1 |
| Hülya, C | 1 |
| Kozdağ, G | 1 |
| Ertaş, G | 1 |
| Aygün, F | 1 |
| Emre, E | 1 |
| Kirbaş, A | 1 |
| Ural, D | 1 |
| Soran, O | 1 |
| Eynan, M | 1 |
| Knubuvetz, T | 1 |
| Meiri, U | 1 |
| Navon, G | 1 |
| Gerstenblith, G | 1 |
| Bromberg, Z | 1 |
| Hasin, Y | 1 |
| Horowitz, M | 1 |
| Pantos, C | 4 |
| Mourouzis, I | 4 |
| Tzeis, S | 3 |
| Moraitis, P | 3 |
| Malliopoulou, V | 4 |
| Cokkinos, DD | 2 |
| Carageorgiou, H | 3 |
| Varonos, D | 2 |
| Cokkinos, D | 1 |
| Paizis, I | 3 |
| Karamanoli, E | 2 |
| Cokkinos, DV | 4 |
| WINTERS, WL | 1 |
| SOLOFF, LA | 1 |
| Cokkinos, AD | 1 |
| Varonos, DD | 2 |
| Sych, IuP | 1 |
| Kalatnikov, VIu | 1 |
| Syrkin, AL | 1 |
| Mel'nichenko, GA | 1 |
| Telkova, IL | 1 |
| Tepliakov, AT | 1 |
| Thempeyioti, A | 1 |
| Dimopoulos, A | 1 |
| Saranteas, T | 1 |
| Xinaris, C | 1 |
| Toft, AD | 1 |
| Bernstein, R | 1 |
| Müller, C | 1 |
| Midtbø, K | 1 |
| Smith, G | 1 |
| Haug, E | 1 |
| Hertzenberg, L | 1 |
| Prasch, F | 1 |
| Wogritsch, S | 1 |
| Hurtl, I | 1 |
| Holm, C | 1 |
| Najemnik, C | 1 |
| Dudczak, R | 1 |
| Morelli, S | 1 |
| Gurgo, AM | 1 |
| Martocchia, A | 1 |
| Falaschi, P | 1 |
| Sabatino, L | 1 |
| Iervasi, G | 1 |
| Ferrazzi, P | 1 |
| Francesconi, D | 1 |
| Chopra, IJ | 1 |
| Pantos, CI | 1 |
| Malliopoulou, VA | 1 |
| Mourouzis, IS | 1 |
| Karamanoli, EP | 1 |
| Tzeis, SM | 1 |
| Carageorgiou, HC | 1 |
| Kohno, A | 1 |
| Hara, Y | 1 |
| Quevedo, I | 1 |
| Mosso, L | 1 |
| Domínguez, JM | 1 |
| Fajuri, A | 1 |
| Quintana, JC | 1 |
| Leese, GP | 1 |
| Jung, RT | 1 |
| Guthrie, C | 1 |
| Waugh, N | 1 |
| Browning, MC | 1 |
| Babin, VP | 1 |
| Stepanova, EG | 1 |
| Malyutina, SK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Cardiopulmonary Resuscitation[NCT04392258] | 200 participants (Anticipated) | Observational | 2021-05-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thyroxine and Myocardial Ischemia
| Article | Year |
|---|---|
[Impairment of cardiovascular function in subclinical hypothyroidism].
Topics: Age Factors; Aged; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Diastole; Echocardi | 2003 |
Thyroxine replacement therapy.
Topics: Dose-Response Relationship, Drug; Female; Humans; Hypothyroidism; Infant, Newborn; Myocardial Ischem | 1993 |
Thyrotoxicosis, unstable angina and normal coronary angiogram.
Topics: Angina, Unstable; Anti-Arrhythmia Agents; Chest Pain; Combined Modality Therapy; Coronary Angiograph | 1999 |
2 trials available for thyroxine and Myocardial Ischemia
| Article | Year |
|---|---|
Clinical effects of enhanced external counterpulsation treatment in patients with ischemic heart failure.
Topics: Aged; Blood Pressure; Cohort Studies; Counterpulsation; Electrocardiography; Female; Heart Failure; | 2012 |
Silent myocardial ischemia in hypothyroidism.
Topics: Adult; Coronary Circulation; Echocardiography; Exercise; Female; Humans; Hypothyroidism; Male; Middl | 1995 |
20 other studies available for thyroxine and Myocardial Ischemia
| Article | Year |
|---|---|
A Cross-Sectional Study Examining the Parametric Thyroid Feedback Quantile Index and Its Relationship with Metabolic and Cardiovascular Diseases.
Topics: Adult; Atrial Fibrillation; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus, Typ | 2022 |
FT4/FT3 ratio: A novel biomarker predicts coronary microvascular dysfunction (CMD) in euthyroid INOCA patients.
Topics: Biomarkers; Coronary Artery Disease; Humans; Myocardial Ischemia; Prospective Studies; Thyroxine; Tr | 2022 |
Usefulness of Serum Free Thyroxine Concentration to Predict Ventricular Arrhythmia Risk in Euthyroid Patients With Structural Heart Disease.
Topics: Aged; Cardiac Pacing, Artificial; Cardiomyopathies; Cohort Studies; Defibrillators, Implantable; Ele | 2020 |
Thyroid function and ischemic heart disease: a Mendelian randomization study.
Topics: Adolescent; Adult; Aged; Autoantibodies; Child; Female; Genotype; Genotyping Techniques; Humans; Iod | 2017 |
IMPORTANCE OF ISOLATED GESTATIONAL HYPOTHYROXINEMIA IN THE DEVELOPMENT OF OBSTETRIC AND SOMATIC PATHOLOGIES.
Topics: Abortion, Spontaneous; Adolescent; Adult; Alopecia; Case-Control Studies; Diabetes Mellitus; Female; | 2018 |
Transient ST-segment elevation due to iatrogenic hyperthyroidism in a patient with normal coronary arteries.
Topics: Angina Pectoris; Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Electrocardiography; Hu | 2011 |
Heat acclimation-induced elevated glycogen, glycolysis, and low thyroxine improve heart ischemic tolerance.
Topics: Acclimatization; Animals; Carbon Isotopes; Glucose; Glycogen; Glycolysis; Hot Temperature; Hypothyro | 2002 |
Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: an effect reversed by thyroxine pretreatment.
Topics: Animals; Cardiotonic Agents; Dobutamine; Heart; Heart Ventricles; In Vitro Techniques; Myocardial Is | 2003 |
Thyroid hormone and cardioprotection: study of p38 MAPK and JNKs during ischaemia and at reperfusion in isolated rat heart.
Topics: Animals; Enzyme Activation; Heart; In Vitro Techniques; Ischemic Preconditioning, Myocardial; JNK Mi | 2003 |
Observations on sodium D-thyroxine as a hypocholesteremic agent in persons with hypercholesteremia with and without ischemic heart disease.
Topics: Anticholesteremic Agents; Cholesterol; Coronary Artery Disease; Coronary Disease; Dextrothyroxine; H | 1962 |
Thyroxine pretreatment increases basal myocardial heat-shock protein 27 expression and accelerates translocation and phosphorylation of this protein upon ischaemia.
Topics: Animals; Gene Expression Regulation; Heat-Shock Proteins; Male; Myocardial Ischemia; Myocardium; Pho | 2003 |
[Changes of thyroid hormone levels in the progression of coronary arteriosclerosis].
Topics: Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Disease Progression; Heart Fail | 2004 |
Hyperthyroid hearts display a phenotype of cardioprotection against ischemic stress: a possible involvement of heat shock protein 70.
Topics: Animals; Cardiomegaly; Cell Survival; Heart; HSP70 Heat-Shock Proteins; Hyperthyroidism; Male; Malon | 2006 |
Severe short-term hypothyroidism is not associated with an increased incidence of myocardial ischemia as assessed by thallium-201 stress/rest myocardial scintigraphy.
Topics: Adult; Aged; Exercise Test; Female; Humans; Hypothyroidism; Iodine Radioisotopes; Male; Middle Aged; | 1999 |
A study of iodothyronine 5'-monodeiodinase activities in normal and pathological tissues in man and their comparison with activities in rat tissues.
Topics: Aged; Animals; Humans; Hydrocortisone; Intestines; Iodide Peroxidase; Iodothyronine Deiodinase Type | 2000 |
Long-term thyroxine administration increases heat stress protein-70 mRNA expression and attenuates p38 MAP kinase activity in response to ischaemia.
Topics: Animals; Cardiomegaly; Chronic Disease; Electrophoresis, Polyacrylamide Gel; HSP70 Heat-Shock Protei | 2001 |
Severe myocardial ischemia following hormone replacement in two cases of hypothyroidism with normal coronary arteriogram.
Topics: Acute Disease; Coronary Angiography; Female; Graves Disease; Humans; Hypothyroidism; Male; Middle Ag | 2001 |
[Reversible myocardial ischemia in hypothyroidism: Case report].
Topics: Coronary Angiography; Humans; Hypothyroidism; Male; Middle Aged; Myocardial Ischemia; Thallium Radio | 2001 |
Morbidity in patients on L-thyroxine: a comparison of those with a normal TSH to those with a suppressed TSH.
Topics: Aged; Breast Neoplasms; Depression, Chemical; Female; Femoral Neck Fractures; Follow-Up Studies; Fra | 1992 |
IHD in Chukotka residents: concentration of thyrotropin, thyroxin, triiodothyronine in blood serum.
Topics: Adult; Humans; Male; Middle Aged; Myocardial Ischemia; Native Hawaiian or Other Pacific Islander; Ra | 1991 |