Page last updated: 2024-11-06

thyroxine and Muscle Weakness

thyroxine has been researched along with Muscle Weakness in 22 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)

Research Excerpts

ExcerptRelevanceReference
"Herein we report a rare case of acquired palmoplantar keratoderma in association with myxoedema and hypothyroidism."1.40[Palmoplantar keratoderma: a rare manifestation of myxoedema]. ( Addi, H; Benchikhi, H; Bouras, M; Farouki, A; Hali, F; Khadir, K, 2014)
"We describe a patient with primary hypothyroidism, presenting solely with a clinical picture of myositis with very high levels of creatine phosphokinase (CPK), which normalised after 12 weeks of treatment with levothyroxine."1.36Myopathy presenting as a sole manifestation of hypothyroidism. ( Jain, R; Kant, S; Kumar, V; Madhu, SV; Prakash, V, 2010)
"Chronic autoimmune thyroiditis was diagnosed in her mother, subsequently."1.35[19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)]. ( Brändle, M; Kehl, O; Lipowsky, C; Schorl-Schweikardt, BA, 2008)
"Primary hypothyroidism is a chronic and insidious disease caused by failure of thyroid hormone production."1.32Hoffman's syndrome: muscle stiffness, pseudohypertrophy and hypothyroidism. ( Baldini, V; Mastropasqua, M; Paggi, A; Spagna, G; Tedesco, I, 2003)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (36.36)29.6817
2010's14 (63.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Powell, A1
Wilson, P1
Powell, T1
Al-Wahaibi, AK1
Kumar, S1
Al-Risi, A1
Wali, F1
Çatli, G1
Fujisawa, H1
Kirbiyik, Ö1
Mimoto, MS1
Gençpinar, P1
Özdemir, TR1
Dündar, BN1
Dumitrescu, AM1
Jervis, W1
Shah, N1
Mongolu, SK1
Sathyapalan, T1
Bouras, M1
Hali, F1
Khadir, K1
Addi, H1
Farouki, A1
Benchikhi, H1
Matta, A1
Koppala, J1
Gossman, W1
Hernán Martínez, J1
Sánchez, A1
Torres, O1
Palermo, C1
Santiago, M1
Figueroa, C1
Trinidad, R1
Mangual, M1
Gutierrez, M1
González, E1
Miranda, Mde L1
Ahmed, GS1
Zaid, HM1
Moloney, M1
Leclère, J1
Cousty, C1
Schlienger, JL1
Wémeau, JL1
Banda, P1
Allain, TJ1
Paz Flores, C1
Rosales Carballa, J1
Blanco Loberías, J1
Rodríguez-Garrocho, A1
Jover-Sáenz, A1
Barcenilla-Gaite, F1
Porcel-Pérez, JM1
Taylor, LJ1
Madhu, SV1
Jain, R1
Kant, S1
Prakash, V1
Kumar, V1
Serranti, D1
Indolfi, G1
Bartolini, E1
Galli, L1
de Martino, M1
Resti, M1
Verma, R1
Lalla, R1
Sahu, R1
Greenwald, JL1
McDermott, S1
Dighe, AS1
Goswami, R1
Guleria, R1
Gupta, AK1
Gupta, N1
Marwaha, RK1
Pande, JN1
Kochupillai, N1
Mastropasqua, M1
Spagna, G1
Baldini, V1
Tedesco, I1
Paggi, A1
Lipowsky, C1
Schorl-Schweikardt, BA1
Kehl, O1
Brändle, M1
Weiss, BM1
Hepburn, MJ1
Mong, DP1
Benvenga, S1
Toscano, A1
Rodolico, C1
Vita, G1
Trimarchi, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Exercise Capacity and Physical Activity Levels in Patients With Hyperthyroid and Healthy Controls[NCT04825964]30 participants (Actual)Observational2021-03-19Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

22 other studies available for thyroxine and Muscle Weakness

ArticleYear
Case 4: Chronic and Progressive Muscle Weakness in a 9-year-old Girl.
    Pediatrics in review, 2019, Volume: 40, Issue:12

    Topics: Child; Creatine Kinase; Diagnosis, Differential; Female; Graves Disease; Humans; Muscle Weakness; Ph

2019
Thyrotoxic Neuropathy: A rare cause of acute flaccid paraplegia.
    Sultan Qaboos University medical journal, 2017, Volume: 17, Issue:4

    Topics: Antithyroid Agents; Carbimazole; Humans; Magnetic Resonance Imaging; Male; Muscle Weakness; Oman; Pa

2017
A Novel Homozygous Selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2, SBP2) Gene Mutation in a Turkish Boy.
    Thyroid : official journal of the American Thyroid Association, 2018, Volume: 28, Issue:9

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Humans; Male; Muscle Weakness; Mutagenesis, In

2018
Severe proximal myopathy secondary to Hashimoto's thyroiditis.
    BMJ case reports, 2019, Jul-27, Volume: 12, Issue:7

    Topics: Adult; Creatine Kinase; Female; Hashimoto Disease; Hormone Replacement Therapy; Humans; Muscle Weakn

2019
[Palmoplantar keratoderma: a rare manifestation of myxoedema].
    Annales de dermatologie et de venereologie, 2014, Volume: 141, Issue:1

    Topics: Eczema; Emollients; Facial Dermatoses; Fatigue; Female; Foot Dermatoses; Hand Dermatoses; Hormone Re

2014
Thyrotoxic hypokalaemic periodic paralysis: a rare presentation of Graves' disease in a Hispanic patient.
    BMJ case reports, 2014, Apr-09, Volume: 2014

    Topics: Adult; Diagnosis, Differential; Graves Disease; Hispanic or Latino; Humans; Hypokalemia; Hypokalemic

2014
Abrupt onset of muscle dysfunction after treatment for Grave's disease: a case report.
    Boletin de la Asociacion Medica de Puerto Rico, 2014, Volume: 106, Issue:1

    Topics: Diagnosis, Differential; Edema; Electromyography; Emergencies; Female; Graves Disease; Hormone Repla

2014
Hashimoto's thyroiditis presenting as Hoffman's syndrome, rhabdomyolysis and acute kidney injury.
    BMJ case reports, 2014, Jul-04, Volume: 2014

    Topics: Acute Kidney Injury; Adult; Fluid Therapy; Follow-Up Studies; Hashimoto Disease; Hormone Replacement

2014
[Subclinical hypothyroidism and quality of life of women aged 50 or more with hypercholesterolemia: results of the HYOGA study].
    Presse medicale (Paris, France : 1983), 2008, Volume: 37, Issue:11

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Anticholesteremic Agents; Asthenia; Attitude to

2008
Ward round--seizures, tremor and muscle weakness 20 years after thyroid surgery.
    Malawi medical journal : the journal of Medical Association of Malawi, 2008, Volume: 20, Issue:1

    Topics: Adult; Brain; Humans; Hypothyroidism; Male; Muscle Weakness; Postoperative Complications; Seizures;

2008
[Muscle weakness as first manifestation of panhypopituitarism secondary to empty sella syndrome].
    Anales de medicina interna (Madrid, Spain : 1984), 2008, Volume: 25, Issue:6

    Topics: Aged; Anti-Inflammatory Agents; Drug Therapy, Combination; Empty Sella Syndrome; Female; Humans; Hyd

2008
[Hoffmann's syndrome as an onset for us of hypothyroid myopathy].
    Medicina clinica, 2010, Jun-12, Volume: 135, Issue:2

    Topics: Adult; Autoimmune Diseases; Humans; Hypertrophy; Hypothyroidism; Male; Muscle Weakness; Muscle, Skel

2010
Think thyroid. Connecting an assortment of symptoms leads to a hypothyroidism diagnosis.
    Advance for NPs & PAs, 2010, Volume: 1, Issue:3

    Topics: Adult; Anorexia; Dizziness; Fatigue; Female; Humans; Hypothyroidism; Muscle Weakness; Physical Exami

2010
Myopathy presenting as a sole manifestation of hypothyroidism.
    The Journal of the Association of Physicians of India, 2010, Volume: 58

    Topics: Adult; Creatine Kinase; Hormone Replacement Therapy; Humans; Hypothyroidism; Male; Muscle Weakness;

2010
Raised serum aminotransferase levels and muscle pseudohypertrophy caused by hypothyroidism.
    Journal of pediatric gastroenterology and nutrition, 2013, Volume: 56, Issue:6

    Topics: Adolescent; Biomarkers; Creatine Kinase; Diagnosis, Differential; Hormone Replacement Therapy; Human

2013
Hypothyroid myopathy mimicking postpolio syndrome.
    BMJ case reports, 2012, Aug-24, Volume: 2012

    Topics: Adult; Calcium; Diagnosis, Differential; Dietary Supplements; Female; Hashimoto Disease; Humans; Hyp

2012
Case records of the Massachusetts General Hospital. Case 35-2012. A 69-year-old chronically ill man with weakness, anorexia, and diffuse pain.
    The New England journal of medicine, 2012, Nov-15, Volume: 367, Issue:20

    Topics: Adrenal Insufficiency; Anorexia; Bradycardia; Brain; Chronic Pain; Diabetes Complications; Diagnosis

2012
Prevalence of diaphragmatic muscle weakness and dyspnoea in Graves' disease and their reversibility with carbimazole therapy.
    European journal of endocrinology, 2002, Volume: 147, Issue:3

    Topics: Adult; Antithyroid Agents; Carbimazole; Diaphragm; Dyspnea; Exercise; Female; Forced Expiratory Volu

2002
Hoffman's syndrome: muscle stiffness, pseudohypertrophy and hypothyroidism.
    Hormone research, 2003, Volume: 59, Issue:2

    Topics: Adult; Creatine Kinase; Exercise; Female; Humans; Hypertrophy; Hypothyroidism; Muscle Fatigue; Muscl

2003
[19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)].
    Praxis, 2008, Jan-23, Volume: 97, Issue:2

    Topics: Addison Disease; Adrenocorticotropic Hormone; Adult; Cortisone; Diagnosis, Differential; Drug Therap

2008
Subacute thyroiditis manifesting as fever of unknown origin.
    Southern medical journal, 2000, Volume: 93, Issue:9

    Topics: Aged; Aged, 80 and over; Blood Sedimentation; Confusion; Diagnosis, Differential; Fever of Unknown O

2000
Endocrine evaluation for muscle pain.
    Journal of the Royal Society of Medicine, 2001, Volume: 94, Issue:8

    Topics: Addison Disease; Adolescent; Anti-Inflammatory Agents; Drug Therapy, Combination; Fludrocortisone; H

2001