thyroxine has been researched along with Muscle Weakness in 22 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Herein we report a rare case of acquired palmoplantar keratoderma in association with myxoedema and hypothyroidism." | 1.40 | [Palmoplantar keratoderma: a rare manifestation of myxoedema]. ( Addi, H; Benchikhi, H; Bouras, M; Farouki, A; Hali, F; Khadir, K, 2014) |
| "We describe a patient with primary hypothyroidism, presenting solely with a clinical picture of myositis with very high levels of creatine phosphokinase (CPK), which normalised after 12 weeks of treatment with levothyroxine." | 1.36 | Myopathy presenting as a sole manifestation of hypothyroidism. ( Jain, R; Kant, S; Kumar, V; Madhu, SV; Prakash, V, 2010) |
| "Chronic autoimmune thyroiditis was diagnosed in her mother, subsequently." | 1.35 | [19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)]. ( Brändle, M; Kehl, O; Lipowsky, C; Schorl-Schweikardt, BA, 2008) |
| "Primary hypothyroidism is a chronic and insidious disease caused by failure of thyroid hormone production." | 1.32 | Hoffman's syndrome: muscle stiffness, pseudohypertrophy and hypothyroidism. ( Baldini, V; Mastropasqua, M; Paggi, A; Spagna, G; Tedesco, I, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 14 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Powell, A | 1 |
| Wilson, P | 1 |
| Powell, T | 1 |
| Al-Wahaibi, AK | 1 |
| Kumar, S | 1 |
| Al-Risi, A | 1 |
| Wali, F | 1 |
| Çatli, G | 1 |
| Fujisawa, H | 1 |
| Kirbiyik, Ö | 1 |
| Mimoto, MS | 1 |
| Gençpinar, P | 1 |
| Özdemir, TR | 1 |
| Dündar, BN | 1 |
| Dumitrescu, AM | 1 |
| Jervis, W | 1 |
| Shah, N | 1 |
| Mongolu, SK | 1 |
| Sathyapalan, T | 1 |
| Bouras, M | 1 |
| Hali, F | 1 |
| Khadir, K | 1 |
| Addi, H | 1 |
| Farouki, A | 1 |
| Benchikhi, H | 1 |
| Matta, A | 1 |
| Koppala, J | 1 |
| Gossman, W | 1 |
| Hernán Martínez, J | 1 |
| Sánchez, A | 1 |
| Torres, O | 1 |
| Palermo, C | 1 |
| Santiago, M | 1 |
| Figueroa, C | 1 |
| Trinidad, R | 1 |
| Mangual, M | 1 |
| Gutierrez, M | 1 |
| González, E | 1 |
| Miranda, Mde L | 1 |
| Ahmed, GS | 1 |
| Zaid, HM | 1 |
| Moloney, M | 1 |
| Leclère, J | 1 |
| Cousty, C | 1 |
| Schlienger, JL | 1 |
| Wémeau, JL | 1 |
| Banda, P | 1 |
| Allain, TJ | 1 |
| Paz Flores, C | 1 |
| Rosales Carballa, J | 1 |
| Blanco Loberías, J | 1 |
| Rodríguez-Garrocho, A | 1 |
| Jover-Sáenz, A | 1 |
| Barcenilla-Gaite, F | 1 |
| Porcel-Pérez, JM | 1 |
| Taylor, LJ | 1 |
| Madhu, SV | 1 |
| Jain, R | 1 |
| Kant, S | 1 |
| Prakash, V | 1 |
| Kumar, V | 1 |
| Serranti, D | 1 |
| Indolfi, G | 1 |
| Bartolini, E | 1 |
| Galli, L | 1 |
| de Martino, M | 1 |
| Resti, M | 1 |
| Verma, R | 1 |
| Lalla, R | 1 |
| Sahu, R | 1 |
| Greenwald, JL | 1 |
| McDermott, S | 1 |
| Dighe, AS | 1 |
| Goswami, R | 1 |
| Guleria, R | 1 |
| Gupta, AK | 1 |
| Gupta, N | 1 |
| Marwaha, RK | 1 |
| Pande, JN | 1 |
| Kochupillai, N | 1 |
| Mastropasqua, M | 1 |
| Spagna, G | 1 |
| Baldini, V | 1 |
| Tedesco, I | 1 |
| Paggi, A | 1 |
| Lipowsky, C | 1 |
| Schorl-Schweikardt, BA | 1 |
| Kehl, O | 1 |
| Brändle, M | 1 |
| Weiss, BM | 1 |
| Hepburn, MJ | 1 |
| Mong, DP | 1 |
| Benvenga, S | 1 |
| Toscano, A | 1 |
| Rodolico, C | 1 |
| Vita, G | 1 |
| Trimarchi, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Exercise Capacity and Physical Activity Levels in Patients With Hyperthyroid and Healthy Controls[NCT04825964] | 30 participants (Actual) | Observational | 2021-03-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
22 other studies available for thyroxine and Muscle Weakness
| Article | Year |
|---|---|
Case 4: Chronic and Progressive Muscle Weakness in a 9-year-old Girl.
Topics: Child; Creatine Kinase; Diagnosis, Differential; Female; Graves Disease; Humans; Muscle Weakness; Ph | 2019 |
Thyrotoxic Neuropathy: A rare cause of acute flaccid paraplegia.
Topics: Antithyroid Agents; Carbimazole; Humans; Magnetic Resonance Imaging; Male; Muscle Weakness; Oman; Pa | 2017 |
A Novel Homozygous Selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2, SBP2) Gene Mutation in a Turkish Boy.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Humans; Male; Muscle Weakness; Mutagenesis, In | 2018 |
Severe proximal myopathy secondary to Hashimoto's thyroiditis.
Topics: Adult; Creatine Kinase; Female; Hashimoto Disease; Hormone Replacement Therapy; Humans; Muscle Weakn | 2019 |
[Palmoplantar keratoderma: a rare manifestation of myxoedema].
Topics: Eczema; Emollients; Facial Dermatoses; Fatigue; Female; Foot Dermatoses; Hand Dermatoses; Hormone Re | 2014 |
Thyrotoxic hypokalaemic periodic paralysis: a rare presentation of Graves' disease in a Hispanic patient.
Topics: Adult; Diagnosis, Differential; Graves Disease; Hispanic or Latino; Humans; Hypokalemia; Hypokalemic | 2014 |
Abrupt onset of muscle dysfunction after treatment for Grave's disease: a case report.
Topics: Diagnosis, Differential; Edema; Electromyography; Emergencies; Female; Graves Disease; Hormone Repla | 2014 |
Hashimoto's thyroiditis presenting as Hoffman's syndrome, rhabdomyolysis and acute kidney injury.
Topics: Acute Kidney Injury; Adult; Fluid Therapy; Follow-Up Studies; Hashimoto Disease; Hormone Replacement | 2014 |
[Subclinical hypothyroidism and quality of life of women aged 50 or more with hypercholesterolemia: results of the HYOGA study].
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Anticholesteremic Agents; Asthenia; Attitude to | 2008 |
Ward round--seizures, tremor and muscle weakness 20 years after thyroid surgery.
Topics: Adult; Brain; Humans; Hypothyroidism; Male; Muscle Weakness; Postoperative Complications; Seizures; | 2008 |
[Muscle weakness as first manifestation of panhypopituitarism secondary to empty sella syndrome].
Topics: Aged; Anti-Inflammatory Agents; Drug Therapy, Combination; Empty Sella Syndrome; Female; Humans; Hyd | 2008 |
[Hoffmann's syndrome as an onset for us of hypothyroid myopathy].
Topics: Adult; Autoimmune Diseases; Humans; Hypertrophy; Hypothyroidism; Male; Muscle Weakness; Muscle, Skel | 2010 |
Think thyroid. Connecting an assortment of symptoms leads to a hypothyroidism diagnosis.
Topics: Adult; Anorexia; Dizziness; Fatigue; Female; Humans; Hypothyroidism; Muscle Weakness; Physical Exami | 2010 |
Myopathy presenting as a sole manifestation of hypothyroidism.
Topics: Adult; Creatine Kinase; Hormone Replacement Therapy; Humans; Hypothyroidism; Male; Muscle Weakness; | 2010 |
Raised serum aminotransferase levels and muscle pseudohypertrophy caused by hypothyroidism.
Topics: Adolescent; Biomarkers; Creatine Kinase; Diagnosis, Differential; Hormone Replacement Therapy; Human | 2013 |
Hypothyroid myopathy mimicking postpolio syndrome.
Topics: Adult; Calcium; Diagnosis, Differential; Dietary Supplements; Female; Hashimoto Disease; Humans; Hyp | 2012 |
Case records of the Massachusetts General Hospital. Case 35-2012. A 69-year-old chronically ill man with weakness, anorexia, and diffuse pain.
Topics: Adrenal Insufficiency; Anorexia; Bradycardia; Brain; Chronic Pain; Diabetes Complications; Diagnosis | 2012 |
Prevalence of diaphragmatic muscle weakness and dyspnoea in Graves' disease and their reversibility with carbimazole therapy.
Topics: Adult; Antithyroid Agents; Carbimazole; Diaphragm; Dyspnea; Exercise; Female; Forced Expiratory Volu | 2002 |
Hoffman's syndrome: muscle stiffness, pseudohypertrophy and hypothyroidism.
Topics: Adult; Creatine Kinase; Exercise; Female; Humans; Hypertrophy; Hypothyroidism; Muscle Fatigue; Muscl | 2003 |
[19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)].
Topics: Addison Disease; Adrenocorticotropic Hormone; Adult; Cortisone; Diagnosis, Differential; Drug Therap | 2008 |
Subacute thyroiditis manifesting as fever of unknown origin.
Topics: Aged; Aged, 80 and over; Blood Sedimentation; Confusion; Diagnosis, Differential; Fever of Unknown O | 2000 |
Endocrine evaluation for muscle pain.
Topics: Addison Disease; Adolescent; Anti-Inflammatory Agents; Drug Therapy, Combination; Fludrocortisone; H | 2001 |