thyroxine has been researched along with Multiple Sclerosis in 16 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Supraphysiological doses of biotin are being tested in patients with multiple sclerosis." | 7.88 | [Apparent thyrotoxicosis in a patient with multiple sclerosis: biochemical assay interference due to high dose biotin use]. ( de Heide, LJM; Lutgers, HL; Slim, CL; van den Berg, R; Wolthuis, A, 2018) |
| "Supraphysiological doses of biotin are being tested in patients with multiple sclerosis." | 3.88 | [Apparent thyrotoxicosis in a patient with multiple sclerosis: biochemical assay interference due to high dose biotin use]. ( de Heide, LJM; Lutgers, HL; Slim, CL; van den Berg, R; Wolthuis, A, 2018) |
| "Nevertheless, very few cases of Graves' disease, occurred in such condition, have been reported in literature." | 1.31 | Long-term treatment with interferon-beta therapy for multiple sclerosis and occurrence of Graves' disease. ( Amato, G; Biondi, B; Carella, C; Del Buono, AD; di Cristofaro, M; Di Iorio, G; Manganella, G; Mazziotti, G; Montella, P; Rotondi, M, 2000) |
| "Interferon beta (IFNB) treatment for multiple sclerosis (MS) has been associated with thyroid disorders (TD), in particular in patients with subclinical TD or anti-thyroid (AT) autoantibodies (autoAb) before starting treatment." | 1.31 | Thyroid function and anti-thyroid antibodies in MS patients screened for interferon treatment. A multicenter study. ( Barbero, P; Bergamasco, B; Brossa, PC; Durelli, L; Faggiano, F; Ghigo, E; Isoardo, GL; Maccario, M; Oggero, A; Verdun, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van den Berg, R | 1 |
| Slim, CL | 1 |
| Lutgers, HL | 1 |
| de Heide, LJM | 1 |
| Wolthuis, A | 1 |
| Weinstock-Guttman, B | 1 |
| Zivadinov, R | 1 |
| Horakova, D | 1 |
| Havrdova, E | 1 |
| Qu, J | 1 |
| Shyh, G | 1 |
| Lakota, E | 1 |
| O'Connor, K | 1 |
| Badgett, D | 1 |
| Tamaño-Blanco, M | 1 |
| Tyblova, M | 1 |
| Hussein, S | 1 |
| Bergsland, N | 1 |
| Willis, L | 1 |
| Krasensky, J | 1 |
| Vaneckova, M | 1 |
| Seidl, Z | 1 |
| Ramanathan, M | 1 |
| Jalkanen, A | 1 |
| Saraste, M | 1 |
| Gfeller, A | 1 |
| Surcel, HM | 1 |
| Airas, L | 1 |
| Marot, D | 1 |
| Maquart, FX | 1 |
| Delemer, B | 1 |
| Decoudier, B | 1 |
| Pieragostino, D | 1 |
| Del Boccio, P | 1 |
| Di Ioia, M | 1 |
| Pieroni, L | 1 |
| Greco, V | 1 |
| De Luca, G | 1 |
| D'Aguanno, S | 1 |
| Rossi, C | 1 |
| Franciotta, D | 1 |
| Centonze, D | 1 |
| Sacchetta, P | 1 |
| Di Ilio, C | 1 |
| Lugaresi, A | 1 |
| Urbani, A | 1 |
| Vecino, MC | 1 |
| Czepielewski, M | 1 |
| Freitas, DM | 1 |
| Vettori, DV | 1 |
| Perla, Ada S | 1 |
| Haussen, DC | 1 |
| Haussen, SR | 1 |
| Fernandez, M | 1 |
| Giuliani, A | 1 |
| Pirondi, S | 1 |
| D'Intino, G | 1 |
| Giardino, L | 1 |
| Aloe, L | 1 |
| Levi-Montalcini, R | 1 |
| Calzà, L | 1 |
| Axelrod, S | 1 |
| Bielory, L | 1 |
| Zhang, B | 1 |
| Jiang, Y | 1 |
| Yang, Y | 1 |
| Peng, F | 1 |
| Hu, X | 1 |
| Warren, TR | 1 |
| Kiessling, WR | 1 |
| Pflughaupt, KW | 1 |
| Haubitz, I | 1 |
| Mertens, HG | 1 |
| Rotondi, M | 2 |
| Oliviero, A | 1 |
| Profice, P | 1 |
| Mone, CM | 1 |
| Biondi, B | 2 |
| Del Buono, A | 1 |
| Mazziotti, G | 2 |
| Sinisi, AM | 1 |
| Bellastella, A | 1 |
| Carella, C | 2 |
| Manganella, G | 1 |
| Del Buono, AD | 1 |
| Montella, P | 1 |
| di Cristofaro, M | 1 |
| Di Iorio, G | 1 |
| Amato, G | 1 |
| Durelli, L | 2 |
| Ferrero, B | 1 |
| Oggero, A | 2 |
| Verdun, E | 2 |
| Ghezzi, A | 1 |
| Montanari, E | 1 |
| Zaffaroni, M | 1 |
| Isoardo, GL | 1 |
| Barbero, P | 1 |
| Bergamasco, B | 1 |
| Brossa, PC | 1 |
| Ghigo, E | 1 |
| Maccario, M | 1 |
| Faggiano, F | 1 |
| Golovkin, VI | 1 |
| Korovin, KF | 1 |
| Iampol'skaia, LI | 1 |
| Dobrov, SA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characteristic Study on Chinese Patients With Multiple Sclerosis[NCT00818103] | 600 participants (Anticipated) | Interventional | 2006-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for thyroxine and Multiple Sclerosis
| Article | Year |
|---|---|
Thyroid function and autoimmunity during interferon beta-1b treatment: a multicenter prospective study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Female; Humans; Interferon beta-1a; Inte | 2001 |
15 other studies available for thyroxine and Multiple Sclerosis
| Article | Year |
|---|---|
[Apparent thyrotoxicosis in a patient with multiple sclerosis: biochemical assay interference due to high dose biotin use].
Topics: Antithyroid Agents; Biotin; Diagnostic Errors; Female; Graves Disease; Humans; Hyperthyroidism; Hypo | 2018 |
Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event.
Topics: Adjuvants, Immunologic; Adult; Body Mass Index; Brain; Calcifediol; Cholesterol; Cholesterol, HDL; C | 2013 |
Increased thyroid autoimmunity among women with multiple sclerosis in the postpartum setting.
Topics: Adult; Antibodies; Case-Control Studies; Delivery, Obstetric; Depression, Postpartum; Fatigue; Femal | 2013 |
Consistent, but Totally Misleading, Thyroid Function Test Results.
Topics: Aged; Antibody Affinity; Biotin; False Positive Reactions; Humans; Hyperthyroidism; Immunoassay; Mal | 2017 |
Oxidative modifications of cerebral transthyretin are associated with multiple sclerosis.
Topics: Adult; Case-Control Studies; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Oxidation-Reduct | 2013 |
[Prevalence of antimicrosomal antibodies in patients with multiple sclerosis].
Topics: Adult; Autoantibodies; Female; Humans; Hypothyroidism; Male; Microsomes; Middle Aged; Multiple Scler | 2004 |
Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease.
Topics: Animals; Demyelinating Autoimmune Diseases, CNS; Disease Models, Animal; Encephalomyelitis, Autoimmu | 2004 |
Beta2-agonists and paresthesias in multiple sclerosis.
Topics: Adrenergic beta-Agonists; Albuterol; Amantadine; Analgesics, Non-Narcotic; Androstadienes; Aromatase | 2007 |
Correlation between serum thyroxine and complements in patients with multiple sclerosis and neuromyelitis optica.
Topics: Adolescent; Adult; Complement System Proteins; Female; Humans; Male; Middle Aged; Multiple Sclerosis | 2008 |
The increased prevalence of multiple sclerosis among people who were born and bred in areas where goitre is endemic.
Topics: Animals; Cattle; Epidemiologic Methods; Goiter, Endemic; Humans; Hyperthyroidism; Infant; Infant Nut | 1984 |
Thyroid function in multiple sclerosis.
Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Thyroid Gland; Thyrotropin | 1980 |
Occurrence of thyroid autoimmunity and dysfunction throughout a nine-month follow-up in patients undergoing interferon-beta therapy for multiple sclerosis.
Topics: Adult; Autoantibodies; Autoimmune Diseases; Autoimmunity; Female; Humans; Interferon-beta; Iodide Pe | 1998 |
Long-term treatment with interferon-beta therapy for multiple sclerosis and occurrence of Graves' disease.
Topics: Adult; Autoantibodies; Female; Graves Disease; Humans; Interferon beta-1a; Interferon beta-1b; Inter | 2000 |
Thyroid function and anti-thyroid antibodies in MS patients screened for interferon treatment. A multicenter study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Causality; Female; Humans; Interferons; | 2001 |
[Neuroendocrine aspects of the pathogenesis and treatment of disseminated sclerosis and lateral amyotrophic sclerosis].
Topics: Adult; Amyotrophic Lateral Sclerosis; Arginine Vasopressin; Diagnosis, Differential; Drug Therapy, C | 1990 |