Page last updated: 2024-11-06

thyroxine and Menopause

thyroxine has been researched along with Menopause in 78 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Menopause: The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.

Research Excerpts

ExcerptRelevanceReference
"A randomized clinical trial was performed in consecutive patients with sporadic nontoxic nodular goiter to compare efficacy and side effects of iodine-131 ((131)I) therapy with suppressive levothyroxine (L-thyroxine) treatment."9.09A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. ( Lips, P; Smits, NJ; Tiel-V Buul, MM; Wesche, MF; Wiersinga, WM, 2001)
"Various plasma hormones were measured in 13 pre- and 20 post-menopausal women with advanced breast cancer before and for 12 months after ovarian irradiation or during continuous administration of tamoxifen at a dose of 10 mg twice a day, respectively; some patients received additional prednisolone at a dose of 5 mg twice a day."9.05Effect of prednisolone on hormone profiles during primary endocrine treatment of advanced breast cancer. ( Blackburn, AM; Bulbrook, RD; Hoare, SA; Kwa, HG; Rubens, RD; Thomas, BS; Wang, DY, 1984)
"Aminoglutethimide is effective in the treatment of breast cancer in postmenopausal patients as a result of its inhibition of aromatase."7.68Low-dose aminoglutethimide in postmenopausal breast cancer: effects on adrenal and thyroid hormone secretion. ( Cantwell, BM; Dowsett, M; Harris, AL; Mehta, A, 1991)
" While this regimen effectively blocked adrenal function, it was complicated by a drug interaction in which aminoglutethimide accelerated the metabolism and reduced the bioavailability of dexamethasone."6.36Kinetic, hormonal and clinical studies with aminoglutethimide in breast cancer. ( Harvey, H; Kendall, J; Lipton, A; Ruby, EB; Samojlik, E; Santen, RJ; Wells, SA, 1977)
"Conventional risk factors for NAFLD were assessed as well as serum levels of TSH, FT3 and FT4."5.42Free triiodothyronine levels are positively associated with non-alcoholic fatty liver disease in euthyroid middle-aged subjects. ( Guan, L; Guan, Q; Jiang, Q; Jiang, Z; Lin, H; Liu, G; Yu, C; Zhang, N; Zhang, X; Zhang, Y; Zheng, X, 2015)
"Many studies have found clinical and metabolic alterations in subclinical hypothyroidism, however, there are disagreements about the benefits of levothyroxine therapy."5.13Treatment of subclinical hypothyroidism reduces atherogenic lipid levels in a placebo-controlled double-blind clinical trial. ( Almeida, CP; Buescu, A; Costa, AJ; Ferreira, MM; Melo, BA; Reis, FA; Reuters, VS; Teixeira, PF; Vaisman, M, 2008)
"In a randomized, controlled study, 59 euthyroid women with surgical menopause were randomized to an estrogen-only (n=20), tibolone (n=20) or calcium-only (n=19) group."5.12Effect of different hormonal therapies on thyroid function in surgical menopause: short-term results. ( Erel, CT; Gezer, A; Kaleli, S; Sentürk, LM; Seyisoglu, H; Somunkiran, A, 2007)
"A randomized clinical trial was performed in consecutive patients with sporadic nontoxic nodular goiter to compare efficacy and side effects of iodine-131 ((131)I) therapy with suppressive levothyroxine (L-thyroxine) treatment."5.09A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. ( Lips, P; Smits, NJ; Tiel-V Buul, MM; Wesche, MF; Wiersinga, WM, 2001)
"Various plasma hormones were measured in 13 pre- and 20 post-menopausal women with advanced breast cancer before and for 12 months after ovarian irradiation or during continuous administration of tamoxifen at a dose of 10 mg twice a day, respectively; some patients received additional prednisolone at a dose of 5 mg twice a day."5.05Effect of prednisolone on hormone profiles during primary endocrine treatment of advanced breast cancer. ( Blackburn, AM; Bulbrook, RD; Hoare, SA; Kwa, HG; Rubens, RD; Thomas, BS; Wang, DY, 1984)
" The aim of this study was analysis of cognitive function levels in reference to thyroid examination: thyroid-stimulating hormone (TSH), total thyroxin (TT4), triiodothyronine (TT3), free thyroxin (FT4), free triiodothyronine (FT3), thyroperoxidase antibodies (TPO-AB), and thyroglobulin antibodies (Tg-AB), TSH receptor antibodies (AB-TSHR) in women after menopause."3.81Functional status of thyroid and cognitive functions after menopause. ( Bojar, I; Gnatowski, M; Gujski, M; Owoc, A; Walecka, I; Witczak, M, 2015)
" We assessed the subjects according to the Simplified Menopause Index, menstrual status, thyroid hormone measurements (thyroid stimulating hormone, free thyroxine, free triiodothyronine), the presence of Hashimoto's disease antibodies (anti-thyroid peroxidase antibody or anti-thyroglobulin antibody), the presence of Grave's disease (anti-TSH receptor antibody), markers of thyroid tumor (high thyroglobulin), and thyroid ultrasonography studies."3.79Comparison of the symptoms of menopause and symptoms of thyroid disease in Japanese women aged 35-59 years. ( Ohi, K; Oi, N, 2013)
"This study evaluated changes of lipids and lipoprotein (a) [Lp (a)] as atherosclerotic risk factors and the effects of levothyroxine (LT4) treatment on these parameters in patient with subclinical hypothyroidism (SH), defined by increased concentrations of thyrotropin (TSH) and normal thyroid hormone concentrations."3.72Lipid profile and lipoprotein (a) as a risk factor for cardiovascular disease in women with subclinical hypothyroidism. ( Canturk, NZ; Canturk, Z; Cetinarslan, B; Ozden, M; Tarkun, I, 2003)
"Aminoglutethimide is effective in the treatment of breast cancer in postmenopausal patients as a result of its inhibition of aromatase."3.68Low-dose aminoglutethimide in postmenopausal breast cancer: effects on adrenal and thyroid hormone secretion. ( Cantwell, BM; Dowsett, M; Harris, AL; Mehta, A, 1991)
"Serum tri-iodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) concentrations were measured in 50 postmenopausal patients with breast cancer receiving tamoxifen therapy."3.67The effect of tamoxifen therapy on thyroid function tests. ( Beastall, GH; Gordon, D; McArdle, CS; Thomson, JA, 1986)
"Levels of circulating estrone (E1), estradiol (E2), androst-4-ene-3,17-dione (Adione), 3,5,3'-triiodothyronine (T3), thyroxine (T4), and sex hormone-binding globulin (SHBG) were measured in 10 obese postmenopausal patients with breast cancer and in 10 obese postmenopausal control subjects matched for age, body size, and menopausal status."3.67Decrease of circulating level of SHBG in postmenopausal obese women as a risk factor in breast cancer: reversible effect of weight loss. ( Cardillo, LR; del Carmen Cremona, M; Enriori, CL; Etkin, AE; Orsini, W; Reforzo-Membrives, J, 1986)
"Serum levels of thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free triidotthyronine (FT3), free thyroxine (FT4) and thyroxine-binding globulin (TBG) were measured in 382 healthy women who were attending a menopause clinic."3.66A study of thyroid function in the pre- and post-menopause. ( Bottiglioni, F; Capelli, M; de Aloysio, D; Mantuano, R; Mauloni, M; Nicoletti, G, 1983)
" A significant dose-response was not found."2.42The effect of levothyroxine therapy on bone mineral density: a systematic review of the literature. ( Reiners, C; Schneider, R, 2003)
" While this regimen effectively blocked adrenal function, it was complicated by a drug interaction in which aminoglutethimide accelerated the metabolism and reduced the bioavailability of dexamethasone."2.36Kinetic, hormonal and clinical studies with aminoglutethimide in breast cancer. ( Harvey, H; Kendall, J; Lipton, A; Ruby, EB; Samojlik, E; Santen, RJ; Wells, SA, 1977)
"Conventional risk factors for NAFLD were assessed as well as serum levels of TSH, FT3 and FT4."1.42Free triiodothyronine levels are positively associated with non-alcoholic fatty liver disease in euthyroid middle-aged subjects. ( Guan, L; Guan, Q; Jiang, Q; Jiang, Z; Lin, H; Liu, G; Yu, C; Zhang, N; Zhang, X; Zhang, Y; Zheng, X, 2015)
"Hypothyroidism is more frequent in woman and raises with age."1.35[Hypothyroidism associated to menopause symptoms worsening change with thyroid substitution therapy]. ( Basurto, L; Córdova Pérez, N; Hernández Valencia, M; Manuel Apolinar, L; Ruiz, M; Vargas, A; Vargas, C; Zárate, A, 2008)
"Treatment with 131I for differentiated thyroid cancer may give a follicle-damaging radiation dose to the ovaries."1.31131I therapy for differentiated thyroid cancer leads to an earlier onset of menopause: results of a retrospective study. ( Bencivelli, W; Ceccarelli, C; Morciano, D; Pacini, F; Pinchera, A, 2001)
"The prevalence of hypothyroidism has been reported to increase with age and to attain up to 10% in older women."1.29Screening for thyroid disease at the menopausal clinic. ( Bissonnette, F; Brossard, JH; D'Amour, P; Faughnan, M; Fugère, P; Lepage, R, 1995)
"When patients with previously treated Graves' disease (n = 4 in each group) were eliminated, the differences in bone density at the hip were no longer seen."1.28Skeletal integrity in premenopausal and postmenopausal women receiving long-term L-thyroxine therapy. ( Block, JE; Friedlander, AL; Genant, HK; Greenspan, FS; Greenspan, SL; Resnick, NM, 1991)
"Toremifene was given within the dose range of 3-680 mg as a single dose or on five consecutive days to 72 postmenopausal volunteers."1.28Effect of toremifene on clinical chemistry, hematology and hormone levels at different doses in healthy postmenopausal volunteers: phase I study. ( Kivinen, S; Mäenpää, J, 1990)
" It is advisable, therefore, to employ a dosage of L-T4 that is carefully monitored to avoid the long-term use of dosages that are excessive for the thyroid condition being treated."1.27Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women. ( Baran, DT; Braverman, LE; Kelly, AM; Kerrigan, J; Paul, TL, 1988)
"In 20 patients with primary hypothyroidism mean serum hTSH-beta was 1."1.25Pituitary secretion of free alpha and beta subunit of human thyrotropin in patients with thyroid disorders. ( Kourides, IA; Maloof, F; Ridgway, EC; Weintraub, BD, 1975)

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-199037 (47.44)18.7374
1990's22 (28.21)18.2507
2000's13 (16.67)29.6817
2010's4 (5.13)24.3611
2020's2 (2.56)2.80

Authors

AuthorsStudies
Slopien, R1
Owecki, M1
Slopien, A1
Bala, G1
Meczekalski, B1
Sousa, BÉCA1
Silva, BC1
de Oliveira Guidotti, T1
Pires, MC1
Soares, MMS1
Kakehasi, AM1
Tournis, S1
Antoniou, JD1
Liakou, CG1
Christodoulou, J1
Papakitsou, E1
Galanos, A1
Makris, K1
Marketos, H1
Nikopoulou, S1
Tzavara, I1
Triantafyllopoulos, IK1
Dontas, I1
Papaioannou, N1
Lyritis, GP1
Alevizaki, M1
Liu, G1
Zheng, X1
Guan, L1
Jiang, Z1
Lin, H1
Jiang, Q1
Zhang, N1
Zhang, Y1
Zhang, X1
Yu, C1
Guan, Q1
Bojar, I1
Owoc, A1
Gujski, M1
Witczak, M1
Gnatowski, M1
Walecka, I1
Hernández Valencia, M1
Córdova Pérez, N1
Zárate, A1
Basurto, L1
Manuel Apolinar, L1
Ruiz, M1
Vargas, C1
Vargas, A1
Oi, N1
Ohi, K1
Loviselli, A1
Rizzolo, E1
Mastinu, R1
Velluzzi, F1
Secci, G1
Taberlet, A1
Mariotti, S1
SPENCE, AW1
Canturk, Z1
Cetinarslan, B1
Tarkun, I1
Canturk, NZ1
Ozden, M1
Schneider, R1
Reiners, C1
Babińska, A1
Wiśniewski, P1
Sworczak, K1
Pearce, EN1
Teixeira, PF1
Reuters, VS1
Ferreira, MM1
Almeida, CP1
Reis, FA1
Melo, BA1
Buescu, A1
Costa, AJ1
Vaisman, M1
Erel, CT1
Gezer, A1
Sentürk, LM1
Somunkiran, A1
Kaleli, S1
Seyisoglu, H1
Blackburn, AM1
Wang, DY1
Bulbrook, RD1
Thomas, BS1
Kwa, HG1
Hoare, SA1
Rubens, RD1
Bottiglioni, F1
de Aloysio, D1
Nicoletti, G1
Mauloni, M1
Mantuano, R1
Capelli, M1
Abdalla, HI1
Hart, DM1
Beastall, GH2
Balan, VE1
Gordon, M1
Gryfe, CI1
Faughnan, M1
Lepage, R1
Fugère, P1
Bissonnette, F1
Brossard, JH1
D'Amour, P1
Dryzhak, VI1
Földes, J1
Tarján, G1
Szathmari, M1
Varga, F1
Krasznai, I1
Horvath, C1
Gutowski, NJ1
Heron, JR1
Ongphiphadhanakul, B1
Puavilai, G1
Rajatanavin, R1
Gyulai, L1
Jaggi, J1
Bauer, MS1
Younkin, S1
Rubin, L1
Attie, M1
Whybrow, PC1
Pop, VJ1
Maartens, LH1
Leusink, G1
van Son, MJ1
Knottnerus, AA1
Ward, AM1
Metcalfe, R1
Weetman, AP1
Rachedi, F1
Rohmer, V1
Six, P1
Duquenne, M1
Wion Barbot, N1
Minebois, A1
Bigorgne, JC1
Audran, M1
Peterson, DD1
Schmidt, RM1
Bellipanni, G1
Bianchi, P1
Pierpaoli, W1
Bulian, D1
Ilyia, E1
Wesche, MF1
Tiel-V Buul, MM1
Lips, P1
Smits, NJ1
Wiersinga, WM1
Ceccarelli, C1
Bencivelli, W1
Morciano, D1
Pinchera, A1
Pacini, F1
Lindblom, P1
Valdemarsson, S1
Lindergård, B1
Westerdahl, J1
Bergenfelz, A1
Serraclara, A1
Jódar, E1
Sarabia, F1
Hawkins, F1
Smallridge, RC1
Wartofsky, L2
Dimond, RC2
Santen, RJ2
Samojlik, E1
Lipton, A2
Harvey, H2
Ruby, EB1
Wells, SA2
Kendall, J1
Medeiros-Neto, GA1
Knobel, M1
Barros, A1
de Ulhoa Cintra, AB1
Rutlin, E1
Haug, E1
Torjesen, PA1
Haagensen, DE1
Ruby, EJ1
Dilley, WG1
Lee, SG1
Lundy, LE1
Kashef, M1
Dorn, J1
Hall, R1
Gomez-Pan, A1
Malarkey, WB1
Schroeder, LL1
Stevens, VC1
James, AG1
Lanese, RR1
Hullin, RP1
McDonald, R1
Allsopp, MN1
Kourides, IA1
Weintraub, BD1
Ridgway, EC1
Maloof, F1
Franklyn, JA1
Betteridge, J1
Daykin, J1
Holder, R1
Oates, GD1
Parle, JV1
Lilley, J1
Heath, DA1
Sheppard, MC1
Rossmanith, WG2
Stäbler, C1
Benz, R1
Bornstein, SR1
Scherbaum, WA2
Astrup, A1
Buemann, B1
Christensen, NJ1
Madsen, J1
Gluud, C1
Bennett, P1
Svenstrup, B1
Pioli, G1
Pedrazzoni, M1
Palummeri, E1
Sianesi, M1
Del Frate, R1
Vescovi, PP1
Prisco, M1
Ulietti, V1
Costi, D1
Passeri, M1
Szilagyi, A1
Chute, J1
Shakir, KM1
Lehmke, J1
Bogner, U1
Felsenberg, D1
Peters, H1
Schleusener, H1
Dowsett, M1
Mehta, A1
Cantwell, BM1
Harris, AL1
Greenspan, SL1
Greenspan, FS1
Resnick, NM1
Block, JE1
Friedlander, AL1
Genant, HK1
Adlin, EV1
Maurer, AH1
Marks, AD1
Channick, BJ1
Diamond, T1
Nery, L1
Hales, I1
Kivinen, S1
Mäenpää, J1
Gebhart, SS1
Watts, NB1
Clark, RV1
Umpierrez, G1
Sgoutas, D1
Takatani, O1
Okumoto, T1
Kosano, H1
Nishida, M1
Hiraide, H1
Tamakuma, S1
Custro, N1
Scafidi, V1
Celani, MF1
Giambuzzi, G1
Simoni, M1
Montanini, V1
Kissebah, AH1
Schectman, G1
Paul, TL1
Kerrigan, J1
Kelly, AM1
Braverman, LE1
Baran, DT1
Rachev, E1
Zakharieva, B1
Vasilev, D1
Gordon, D1
McArdle, CS1
Thomson, JA1
Krølner, B1
Quint, AR1
Kaiser, FE1
Dogliotti, L1
Faggiuolo, R1
Ferusso, A1
Orlandi, F1
Sandrucci, S1
Tibo, A1
Angeli, A1
Oberkotter, LV1
Farmer, LC1
Farber, M1
Enriori, CL1
Orsini, W1
del Carmen Cremona, M1
Etkin, AE1
Cardillo, LR1
Reforzo-Membrives, J1
Robboy, MS1
Sato, AS1
Schwabe, AD1
Caplan, RH1
Dobben, GD1
Kolendorf, K1
Siersbaek-Nielsen, K1
Hansen, MJ1
Friis, T1
Heath, H1
Lee, RB1
Tulchinsky, D1
Chopra, IJ1
Pérez-Vega, E1
Aguilar-Parada, E1
Kato-Kato, A1
Ibarra, A1
Cropp, GJ1
Myers, DN1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Predicting Adaptive Thermogenesis[NCT00687115]Phase 283 participants (Actual)Interventional2008-09-18Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for thyroxine and Menopause

ArticleYear
The effect of levothyroxine therapy on bone mineral density: a systematic review of the literature.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2003, Volume: 111, Issue:8

    Topics: Age Factors; Bone Density; Cohort Studies; Cross-Sectional Studies; Dose-Response Relationship, Drug

2003
[Contemporary view on subclinical hyperthyroidism].
    Polskie Archiwum Medycyny Wewnetrznej, 2006, Volume: 116, Issue:2

    Topics: Bone Diseases, Metabolic; Causality; Comorbidity; Female; Humans; Hyperthyroidism; Male; Menopause;

2006
Thyroid dysfunction in perimenopausal and postmenopausal women.
    Menopause international, 2007, Volume: 13, Issue:1

    Topics: Female; Humans; Hypothyroidism; Menopause; Thyroid Function Tests; Thyrotoxicosis; Thyrotropin; Thyr

2007
Kinetic, hormonal and clinical studies with aminoglutethimide in breast cancer.
    Cancer, 1977, Volume: 39, Issue:6 Suppl

    Topics: Adrenocorticotropic Hormone; Aldosterone; Aminoglutethimide; Androstenedione; Breast Neoplasms; Dehy

1977
The hypothalamic regulatory hormones and their clinical applications.
    Advances in clinical chemistry, 1976, Volume: 18

    Topics: Female; Follicle Stimulating Hormone; Gastrins; Glucagon; Gonadotropin-Releasing Hormone; Humans; Hy

1976
Hormones and lipoprotein metabolism.
    Bailliere's clinical endocrinology and metabolism, 1987, Volume: 1, Issue:3

    Topics: Catecholamines; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glucagon; Glucocortico

1987
Lumbar spine bone mineral content by photon beam absorptiometry. Methodology and application in osteoporosis.
    Danish medical bulletin, 1985, Volume: 32, Issue:3

    Topics: Aging; Female; Fractures, Bone; Humans; Hyperthyroidism; Lumbar Vertebrae; Menopause; Methods; Miner

1985

Trials

6 trials available for thyroxine and Menopause

ArticleYear
Treatment of subclinical hypothyroidism reduces atherogenic lipid levels in a placebo-controlled double-blind clinical trial.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2008, Volume: 40, Issue:1

    Topics: Atherosclerosis; Double-Blind Method; Female; Humans; Hypothyroidism; Lipid Metabolism; Male; Menopa

2008
Effect of different hormonal therapies on thyroid function in surgical menopause: short-term results.
    The Journal of reproductive medicine, 2007, Volume: 52, Issue:12

    Topics: Adult; Calcium; Estrogen Receptor Modulators; Estrogen Replacement Therapy; Estrogens; Estrogens, Co

2007
Effect of prednisolone on hormone profiles during primary endocrine treatment of advanced breast cancer.
    Cancer treatment reports, 1984, Volume: 68, Issue:12

    Topics: Breast Neoplasms; Clinical Trials as Topic; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate;

1984
Reduced serum free thyroxine concentration in postmenopausal women receiving oestrogen treatment.
    British medical journal (Clinical research ed.), 1984, Mar-10, Volume: 288, Issue:6419

    Topics: Female; Humans; Menopause; Mestranol; Middle Aged; Thyrotropin; Thyroxine; Thyroxine-Binding Protein

1984
Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study.
    Experimental gerontology, 2001, Volume: 36, Issue:2

    Topics: Adult; Affect; Circadian Rhythm; Depression; Double-Blind Method; Female; Follicle Stimulating Hormo

2001
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:3

    Topics: Bone Density; Bone Remodeling; Female; Goiter; Humans; Hypothyroidism; Iodine Radioisotopes; Male; M

2001

Other Studies

65 other studies available for thyroxine and Menopause

ArticleYear
Climacteric symptoms are related to thyroid status in euthyroid menopausal women.
    Journal of endocrinological investigation, 2020, Volume: 43, Issue:1

    Topics: Adult; Aged; Biomarkers; Climacteric; Female; Follow-Up Studies; Humans; Menopause; Middle Aged; Pro

2020
Trabecular bone score in women with differentiated thyroid cancer on long-term TSH-suppressive therapy.
    Journal of endocrinological investigation, 2021, Volume: 44, Issue:10

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Bone Density; Brazil; Cancellous Bone; C

2021
Volumetric bone mineral density and bone geometry assessed by peripheral quantitative computed tomography in women with differentiated thyroid cancer under TSH suppression.
    Clinical endocrinology, 2015, Volume: 82, Issue:2

    Topics: Adult; Bone and Bones; Bone Density; Case-Control Studies; Cone-Beam Computed Tomography; Female; Ho

2015
Free triiodothyronine levels are positively associated with non-alcoholic fatty liver disease in euthyroid middle-aged subjects.
    Endocrine research, 2015, Volume: 40, Issue:4

    Topics: Adult; China; Comorbidity; Female; Humans; Male; Menopause; Metabolic Syndrome; Middle Aged; Non-alc

2015
Functional status of thyroid and cognitive functions after menopause.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, Jun-04, Volume: 21

    Topics: Analysis of Variance; Attention; Cognition; Executive Function; Female; Humans; Menopause; Middle Ag

2015
[Hypothyroidism associated to menopause symptoms worsening change with thyroid substitution therapy].
    Ginecologia y obstetricia de Mexico, 2008, Volume: 76, Issue:10

    Topics: Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Longitudinal Studies; Menopause; Middle

2008
Comparison of the symptoms of menopause and symptoms of thyroid disease in Japanese women aged 35-59 years.
    Climacteric : the journal of the International Menopause Society, 2013, Volume: 16, Issue:5

    Topics: Adult; Arrhythmias, Cardiac; Autoantibodies; Diagnosis, Differential; Female; Flushing; Graves Disea

2013
High serum circulating telopeptide type I in multinodular goiter.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2003, Volume: 35, Issue:6

    Topics: Adult; Aged; Biomarkers; Collagen Type I; Female; Goiter, Nodular; Humans; Hyperthyroidism; Menopaus

2003
HORMONAL DISTURBANCES IN THE ELDERLY.
    The Practitioner, 1964, Volume: 192

    Topics: Aged; Aging; Androgens; Calcium; Calcium, Dietary; Diethylstilbestrol; Endocrinology; Erectile Dysfu

1964
Lipid profile and lipoprotein (a) as a risk factor for cardiovascular disease in women with subclinical hypothyroidism.
    Endocrine research, 2003, Volume: 29, Issue:3

    Topics: Adult; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Case-Control Studies; Cholesterol; Es

2003
A study of thyroid function in the pre- and post-menopause.
    Maturitas, 1983, Volume: 5, Issue:2

    Topics: Adult; Aging; Climacteric; Female; Humans; Menopause; Middle Aged; Thyroid Gland; Thyrotropin; Thyro

1983
[Function of the thyrotropic-thyroid system in physiological and pathological climacteric].
    Akusherstvo i ginekologiia, 1983, Issue:2

    Topics: Adult; Climacteric; Female; Humans; Menopause; Menstruation; Middle Aged; Pituitary Gland, Anterior;

1983
Hyperthyroidism with painless subacute thyroiditis in the elderly.
    JAMA, 1981, Nov-20, Volume: 246, Issue:20

    Topics: Age Factors; Aged; Female; Humans; Hyperthyroidism; Menopause; Middle Aged; Pain; Syndrome; Thyroidi

1981
Screening for thyroid disease at the menopausal clinic.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1995, Volume: 18, Issue:1

    Topics: Ambulatory Care Facilities; Autoantibodies; Biomarkers; Female; Humans; Hypothyroidism; Mass Screeni

1995
[Thyroid function in breast cancer patients].
    Voprosy onkologii, 1993, Volume: 39, Issue:4-6

    Topics: Adult; Breast Neoplasms; Female; Humans; Menopause; Middle Aged; Radioimmunoassay; Thyroid Gland; Th

1993
Bone mineral density in patients with endogenous subclinical hyperthyroidism: is this thyroid status a risk factor for osteoporosis?
    Clinical endocrinology, 1993, Volume: 39, Issue:5

    Topics: Adult; Aged; Bone Density; Cross-Sectional Studies; Female; Femur Neck; Goiter, Nodular; Humans; Hyp

1993
Recurrent confusion and hypopituitarism.
    Postgraduate medical journal, 1993, Volume: 69, Issue:811

    Topics: Confusion; Female; Humans; Hydrocortisone; Hypopituitarism; Menopause; Middle Aged; Recurrence; Thyr

1993
Effect of TSH-suppressive doses of levothyroxine on bone mineral density in Thai women.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1996, Volume: 79, Issue:9

    Topics: Absorptiometry, Photon; Adult; Aged; Bone Density; Female; Humans; Menopause; Middle Aged; Thailand;

1996
Bone mineral density and L-thyroxine treatment in rapidly cycling bipolar disorder.
    Biological psychiatry, 1997, Feb-15, Volume: 41, Issue:4

    Topics: Adult; Bipolar Disorder; Bone Density; Cross-Sectional Studies; Female; Humans; Menopause; Middle Ag

1997
Are autoimmune thyroid dysfunction and depression related?
    The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:9

    Topics: Autoantibodies; Autoimmune Diseases; Cohort Studies; Depression; Female; Humans; Hyperthyroidism; Hy

1998
[Prolonged suppressive L-thyroxine therapy. Longitudinal study of the effect of LT4 on bone mineral density and bone metabolism markers in 71 patients].
    Presse medicale (Paris, France : 1983), 1999, Feb-20, Volume: 28, Issue:7

    Topics: Adult; Bone Density; Bone Remodeling; Calcification, Physiologic; Estrogen Replacement Therapy; Fema

1999
Longitudinal and cross-sectional analysis of HEALTH WATCH data with a subset of perimenopausal women and matched controls.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1999, Volume: 54, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alkaline Phosphatase; Case-Control Studies; Cohor

1999
131I therapy for differentiated thyroid cancer leads to an earlier onset of menopause: results of a retrospective study.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:8

    Topics: Adult; Age Factors; Combined Modality Therapy; Female; Follow-Up Studies; Goiter; Humans; Iodine Rad

2001
Decreased levels of ionized calcium one year after hemithyroidectomy: importance of reduced thyroid hormones.
    Hormone research, 2001, Volume: 55, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Bone Density; Calcitriol; Calcium; Collagen; Collagen Type I; Female

2001
Bone mass after long-term euthyroidism in former hyperthyroid women treated with (131)I influence of menopausal status.
    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry, 2001,Fall, Volume: 4, Issue:3

    Topics: Absorptiometry, Photon; Aged; Biomarkers; Body Mass Index; Bone Density; Cross-Sectional Studies; Fe

2001
Inappropriate secretion of thyrotropin: discordance between the suppressive effects of corticosteroids and thyroid hormone.
    The Journal of clinical endocrinology and metabolism, 1979, Volume: 48, Issue:4

    Topics: Acromegaly; Female; Growth Hormone; Humans; Hyperthyroidism; Menopause; Methimazole; Middle Aged; Pr

1979
[Pituitary response to synthetic LH-RH stimulus in patients with hypothyroidism, before and after treatment with thyroxine and triiodothyronine].
    Revista do Hospital das Clinicas, 1978, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Female; Gonadotropin-Releasing Hormone; Humans; Hypothalamus; Hypothyroidism; Mal

1978
Serum thyrotrophin, prolactin and growth hormone, response to TRH during oestrogen treatment.
    Acta endocrinologica, 1977, Volume: 84, Issue:1

    Topics: Adult; Aged; Estradiol; Estrogens; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Lut

1977
Medical adrenalectomy with aminoglutethimide: clinical studies in postmenopausal patients with metastatic breast carcinoma.
    Annals of surgery, 1978, Volume: 187, Issue:5

    Topics: Adrenal Cortex; Adrenalectomy; Aldosterone; Aminoglutethimide; Androstenedione; Bone Neoplasms; Brea

1978
Influence of thyrotropin-releasing hormone on the postmenopausal female.
    Obstetrics and gynecology, 1975, Volume: 45, Issue:1

    Topics: Administration, Oral; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Luteinizing

1975
Twenty-four-hour preoperative endocrine profiles in women with benign and malignant breast disease.
    Cancer research, 1977, Volume: 37, Issue:12

    Topics: Adult; Breast Neoplasms; Circadian Rhythm; Estradiol; Female; Follicle Stimulating Hormone; Follicul

1977
Further report on prophylatic lithium in recurrent affective disorders.
    The British journal of psychiatry : the journal of mental science, 1975, Volume: 126

    Topics: Adult; Affective Symptoms; Age Factors; Aged; Bipolar Disorder; Bone and Bones; Calcium; Female; Hos

1975
Pituitary secretion of free alpha and beta subunit of human thyrotropin in patients with thyroid disorders.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 40, Issue:5

    Topics: Adult; Age Factors; Aged; Apoproteins; Female; Follicle Stimulating Hormone; Humans; Hypothyroidism;

1975
Long-term thyroxine treatment and bone mineral density.
    Lancet (London, England), 1992, Jul-04, Volume: 340, Issue:8810

    Topics: Absorptiometry, Photon; Adult; Aged; Alkaline Phosphatase; Body Mass Index; Bone Density; Calcium; C

1992
Role of ovarian sex steroids in the regulation of thyrotropin (TSH) secretion of hypogonadal women.
    Acta endocrinologica, 1992, Volume: 127, Issue:2

    Topics: Administration, Oral; Estradiol; Female; Humans; Hypogonadism; Menopause; Middle Aged; Progesterone;

1992
The contribution of body composition, substrates, and hormones to the variability in energy expenditure and substrate utilization in premenopausal women.
    The Journal of clinical endocrinology and metabolism, 1992, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Blood Glucose; Body Composition; C-Peptide; Calorimetry; Dehydroepiandrosterone;

1992
Longitudinal study of bone loss after thyroidectomy and suppressive thyroxine therapy in premenopausal women.
    Acta endocrinologica, 1992, Volume: 126, Issue:3

    Topics: Adult; Bone Density; Bone Resorption; Calcitonin; Female; Humans; Longitudinal Studies; Menopause; M

1992
Episodic thyrotropin (TSH) and prolactin (PRL) secretion during aging in postmenopausal women.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1992, Volume: 24, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Female; Humans; Menopause; Middle Aged; Periodicity; Prolactin; Thyr

1992
Bone density and L-thyroxine therapy.
    The American journal of medicine, 1992, Volume: 92, Issue:6

    Topics: Bone Density; Female; Humans; Menopause; Thyroxine

1992
Determination of bone mineral density by quantitative computed tomography and single photon absorptiometry in subclinical hyperthyroidism: a risk of early osteopaenia in post-menopausal women.
    Clinical endocrinology, 1992, Volume: 36, Issue:5

    Topics: Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Bone Density; Bone Diseases, Metabolic; Calc

1992
Low-dose aminoglutethimide in postmenopausal breast cancer: effects on adrenal and thyroid hormone secretion.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:7

    Topics: 17-alpha-Hydroxyprogesterone; Adrenocorticotropic Hormone; Aminoglutethimide; Androstenedione; Breas

1991
Skeletal integrity in premenopausal and postmenopausal women receiving long-term L-thyroxine therapy.
    The American journal of medicine, 1991, Volume: 91, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Bone Density; Female; Femur; Femur Neck; Follow-Up Studies; Graves D

1991
Thyroxine replacement therapy--too much of a good thing?
    Lancet (London, England), 1990, Dec-01, Volume: 336, Issue:8727

    Topics: Bone Density; Drug Administration Schedule; Female; Humans; Hypothyroidism; Menopause; Thyrotropin;

1990
Bone mineral density in postmenopausal women treated with L-thyroxine.
    The American journal of medicine, 1991, Volume: 90, Issue:3

    Topics: Aged; Bone Density; Calcitonin; Female; Femur Neck; Humans; Hyperthyroidism; Lumbar Vertebrae; Menop

1991
A therapeutic dilemma: suppressive doses of thyroxine significantly reduce bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma.
    The Journal of clinical endocrinology and metabolism, 1991, Volume: 72, Issue:6

    Topics: Adult; Bone Density; Carcinoma; Female; Humans; Menopause; Middle Aged; Thyroid Neoplasms; Thyroxine

1991
Effect of toremifene on clinical chemistry, hematology and hormone levels at different doses in healthy postmenopausal volunteers: phase I study.
    Journal of steroid biochemistry, 1990, Jun-22, Volume: 36, Issue:3

    Topics: Adult; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dose-Response Relationship, Drug;

1990
Reversible impairment of gonadotropin secretion in critical illness. Observations in postmenopausal women.
    Archives of internal medicine, 1989, Volume: 149, Issue:7

    Topics: Aged; Aged, 80 and over; Critical Care; Female; Follicle Stimulating Hormone; Humans; Length of Stay

1989
Relationship between the levels of serum thyroid hormones or estrogen status and the risk of breast cancer genesis in Japanese women.
    Cancer research, 1989, Jun-01, Volume: 49, Issue:11

    Topics: Adult; Breast Neoplasms; Estradiol; Female; Humans; Japan; Menopause; Middle Aged; Random Allocation

1989
Mild hyperthyroidism with inappropriate secretion of TSH in postmenopausal women.
    Acta endocrinologica, 1986, Volume: 111, Issue:2

    Topics: Female; Humans; Hyperthyroidism; Hypothalamo-Hypophyseal System; Menopause; Middle Aged; Thyroid Gla

1986
Subnormal prolactin responsiveness to thyrotropin-releasing hormone (TRH) in women with primary empty sella syndrome.
    Journal of endocrinological investigation, 1987, Volume: 10, Issue:4

    Topics: Adenoma; Adult; Empty Sella Syndrome; Female; Humans; Menopause; Middle Aged; Pituitary Neoplasms; P

1987
Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women.
    JAMA, 1988, Jun-03, Volume: 259, Issue:21

    Topics: Adult; Age Factors; Bone Diseases, Metabolic; Female; Femur; Femur Neck; Humans; Lumbar Vertebrae; M

1988
[Thyrotropic-thyroid function in women with uterine hemorrhages in the premenopause].
    Akusherstvo i ginekologiia, 1988, Volume: 27, Issue:1

    Topics: Adult; Climacteric; Female; Humans; Menopause; Middle Aged; Thyroid Gland; Thyrotropin; Thyroxine; T

1988
The effect of tamoxifen therapy on thyroid function tests.
    Cancer, 1986, Oct-01, Volume: 58, Issue:7

    Topics: Breast Neoplasms; Female; Humans; Menopause; Middle Aged; Tamoxifen; Thyroid Function Tests; Thyroid

1986
Gonadotropin determinations and thyrotropin-releasing hormone and luteinizing hormone-releasing hormone testing in critically ill postmenopausal women with hypothyroxinemia.
    The Journal of clinical endocrinology and metabolism, 1985, Volume: 60, Issue:3

    Topics: Adult; Aged; Critical Care; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Go

1985
Prolactin and thyrotropin response to thyrotropin-releasing hormone in premenopausal women with fibrocystic disease of the breast.
    Hormone research, 1985, Volume: 21, Issue:3

    Topics: Adult; Estradiol; Female; Fibrocystic Breast Disease; Humans; Kinetics; Menopause; Middle Aged; Prol

1985
Thyroid hormone-binding inhibitor in normal, pregnant, and lactating rat and postmenopausal human breast tissue.
    Endocrinology, 1985, Volume: 117, Issue:2

    Topics: Animals; Breast; Female; Humans; Kinetics; Lactation; Mammary Glands, Animal; Menopause; Pregnancy;

1985
Decrease of circulating level of SHBG in postmenopausal obese women as a risk factor in breast cancer: reversible effect of weight loss.
    Gynecologic oncology, 1986, Volume: 23, Issue:1

    Topics: Aged; Androstenedione; Body Weight; Breast Neoplasms; Estradiol; Estrone; Female; Humans; Hydrocorti

1986
The hypercarotenemia in anorexia nervosa: a comparison of vitamin A and carotene levels in various forms of menstrual dysfunction and cachexia.
    The American journal of clinical nutrition, 1974, Volume: 27, Issue:4

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adult; Aged; Anorexia Nervosa; Cachexia; Carotenoids; Contrac

1974
Endocrine studies in patients with the "empty sella syndrome".
    Archives of internal medicine, 1969, Volume: 123, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adult; Arginine; Basal Metabolism; Cerebral

1969
Letter: Replacement treatment of hypothyroidism.
    The New England journal of medicine, 1974, Jul-11, Volume: 291, Issue:2

    Topics: Female; Humans; Hyperthyroidism; Hypothyroidism; Menopause; Osteoporosis; Thyroid Hormones; Thyrotro

1974
Evaluation of thyroid status with "effective thyroxine ratio" (E.T.R.).
    Acta endocrinologica, 1974, Volume: 77, Issue:2

    Topics: Adolescent; Adult; Aged; Aspirin; Depression, Chemical; Estrogens; Evaluation Studies as Topic; Fema

1974
Conjugated estrogen therapy and tests of thyroid function.
    Annals of internal medicine, 1974, Volume: 81, Issue:3

    Topics: Dose-Response Relationship, Drug; Estrogens, Conjugated (USP); Female; Humans; Menopause; Protein Bi

1974
Competitive ligand-binding assay for measurement of sex hormone-binding globulin (SHBG).
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 37, Issue:6

    Topics: Adult; Aged; Binding, Competitive; Dihydrotestosterone; Estradiol; Female; Hirsutism; Humans; Hypert

1973
[Free urinary thyroxine].
    Archivos de investigacion medica, 1973, Volume: 4, Issue:3

    Topics: Adult; Breast Neoplasms; Castration; Chromatography, Gel; Diethylstilbestrol; Evaluation Studies as

1973
Physiological evidence of hypermetabolism in osteogenesis imperfecta.
    Pediatrics, 1972, Volume: 49, Issue:3

    Topics: Adolescent; Age Factors; Basal Metabolism; Body Temperature; Body Weight; Cardiac Output; Child; Chi

1972