Page last updated: 2024-11-06

thyroxine and Melanoma

thyroxine has been researched along with Melanoma in 18 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"3,3',5-L-triiodothyronine (T3) can inhibit tyrosinase activity in B16/C3 melanoma cells in culture and block the induction of that enzyme by imidazole (Endocrinol."7.673,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells. ( Kline, EL; Smith, TJ, 1988)
" In two independent experiments oral propylthiouracil (PTU) was used to induce hypothyroidism (n=9), thyroxine to induce hyperthyroidism (n=11) and mice given plain water served as control (n=8)."3.81Low thyroid hormone levels improve survival in murine model for ocular melanoma. ( Ashur-Fabian, O; Cohen, K; Davis, PJ; Ellis, M; Fabian, I; Fabian, ID; Hercbergs, A; Lin, HY; Rosner, M; Shinderman Maman, E; Vishnevskia-Dai, V; Zloto, O, 2015)
"3,3',5-L-triiodothyronine (T3) can inhibit tyrosinase activity in B16/C3 melanoma cells in culture and block the induction of that enzyme by imidazole (Endocrinol."3.673,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells. ( Kline, EL; Smith, TJ, 1988)
"Hypophysitis is one of the most common endocrine abnormalities."1.62Predicting development of ipilimumab-induced hypophysitis: utility of T4 and TSH index but not TSH. ( Greener, V; Lai, ZM; Larkin, J; Morganstein, DL; Siddiqui, MS; Spain, L; Turajlic, S, 2021)
"Blocking the PD-1 pathway induces immune-related adverse events (irAEs) which often involve the thyroid gland (thyroid irAEs)."1.51Incidence, features, and prognosis of immune-related adverse events involving the thyroid gland induced by nivolumab. ( Fujii, T; Hishizawa, M; Inagaki, N; Kawaguchi-Sakita, N; Kim, YH; Kitamura, M; Kitawaki, T; Matsumoto, S; Nomura, M; Otsuka, A; Saito, R; Sakamori, Y; Sone, M; Taura, D; Yamasaki, T; Yamauchi, I; Yasoda, A, 2019)
" Levothyroxine dosing required doubling in three patients with a known history of hypothyroidism."1.46Pembrolizumab-Induced Thyroiditis: Comprehensive Clinical Review and Insights Into Underlying Involved Mechanisms. ( Bornschlegl, S; Delivanis, DA; Dietz, AB; Gustafson, MP; Kottschade, L; Merten, MM; Ryder, M; Withers, S, 2017)
" We report a case highlighting the occurrence of serious induced immune-related adverse events, which were attributed to pembrolizumab in a patient with metastatic melanoma who obtained a complete response (CR) after receiving pembrolizumab for a total of 6."1.46Risk of cumulative toxicity after complete melanoma response with pembrolizumab. ( Brown, MP; Faithfull, S; Hsieh, AH, 2017)
"The patient presented recurrences of metastatic skin nodules, lung and bone metastases, and died after a 3-year follow-up."1.29Cutaneous metastasis from follicular carcinoma of the thyroid gland. ( Bazex, J; Caron, P; Gorguet, B; Moreau-Cabarrot, A, 1993)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19904 (22.22)18.7374
1990's2 (11.11)18.2507
2000's1 (5.56)29.6817
2010's10 (55.56)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Siddiqui, MS1
Lai, ZM1
Spain, L1
Greener, V1
Turajlic, S1
Larkin, J1
Morganstein, DL1
Yamauchi, I2
Sakane, Y1
Fukuda, Y1
Fujii, T2
Taura, D2
Hirata, M1
Hirota, K1
Ueda, Y1
Kanai, Y1
Yamashita, Y1
Kondo, E1
Sone, M2
Yasoda, A2
Inagaki, N2
Delivanis, DA1
Gustafson, MP1
Bornschlegl, S1
Merten, MM1
Kottschade, L1
Withers, S1
Dietz, AB1
Ryder, M1
Ansorge, C1
Seufert, J1
Meiss, F1
von Bubnoff, D1
Peiró, I1
Palmero, R1
Iglesias, P1
Díez, JJ1
Simó-Servat, A1
Marín, JA1
Jiménez, L1
Domingo-Domenech, E1
Mancho-Fora, N1
Nadal, E1
Villabona, C1
Matsumoto, S1
Sakamori, Y1
Kim, YH1
Nomura, M1
Otsuka, A1
Yamasaki, T1
Saito, R1
Kitamura, M1
Kitawaki, T1
Hishizawa, M1
Kawaguchi-Sakita, N1
Anderson, L1
Bhatia, V1
McElnea, E1
Ní Mhéalóid, A1
Moran, S1
Kelly, R1
Fulcher, T1
Fabian, ID1
Rosner, M1
Fabian, I1
Vishnevskia-Dai, V1
Zloto, O1
Shinderman Maman, E1
Cohen, K1
Ellis, M1
Lin, HY1
Hercbergs, A1
Davis, PJ1
Ashur-Fabian, O1
Tanaka, R1
Fujisawa, Y1
Maruyama, H1
Nakamura, Y1
Yoshino, K1
Ohtsuka, M1
Fujimoto, M1
Hsieh, AH1
Faithfull, S1
Brown, MP1
STOLK, A1
Larsson, B1
Olander, K1
Dencker, L1
Holmqvist, L1
Caron, P1
Moreau-Cabarrot, A1
Gorguet, B1
Bazex, J1
Guerra, L1
Leiros, G1
Sacerdote de Lustig, E1
Phan, GQ1
Attia, P1
Steinberg, SM1
White, DE1
Rosenberg, SA1
Smith, TJ1
Kline, EL1
Sadoff, L1
Lusk, W1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma[NCT03918252]Phase 230 participants (Anticipated)Interventional2019-10-02Recruiting
Neoadjuvant Nivolumab, or Nivolumab in Combination With Ipilimumab, in Resectable Non-Small-Cell Lung Cancer.[NCT02259621]Phase 245 participants (Anticipated)Interventional2014-09-30Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

18 other studies available for thyroxine and Melanoma

ArticleYear
Predicting development of ipilimumab-induced hypophysitis: utility of T4 and TSH index but not TSH.
    Journal of endocrinological investigation, 2021, Volume: 44, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Immunological; Biomarkers; Female; Follow-Up Studies; Humans; Hy

2021
Clinical Features of Nivolumab-Induced Thyroiditis: A Case Series Study.
    Thyroid : official journal of the American Thyroid Association, 2017, Volume: 27, Issue:7

    Topics: Aged; Antibodies, Monoclonal; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Lung Neoplasm

2017
Pembrolizumab-Induced Thyroiditis: Comprehensive Clinical Review and Insights Into Underlying Involved Mechanisms.
    The Journal of clinical endocrinology and metabolism, 2017, 08-01, Volume: 102, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Autoantibo

2017
Sequential occurrence of primary and secondary hypothyroidism during treatment with nivolumab: pitfalls in immuno-oncological therapy and endocrinological diagnostic procedures.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2018, Volume: 16, Issue:12

    Topics: Adult; Antineoplastic Agents, Immunological; Autoimmune Hypophysitis; Humans; Hydrocortisone; Hypopi

2018
Thyroid dysfunction induced by nivolumab: searching for disease patterns and outcomes.
    Endocrine, 2019, Volume: 64, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Immunological; Carcinoma, Non-Small-Cell Lung; Female; Hodgkin D

2019
Incidence, features, and prognosis of immune-related adverse events involving the thyroid gland induced by nivolumab.
    PloS one, 2019, Volume: 14, Issue:5

    Topics: Aged; Antineoplastic Agents, Immunological; Carcinoma, Non-Small-Cell Lung; Female; Fluorodeoxygluco

2019
Ipilimumab immune-related adverse reactions: a case report.
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2013, Volume: 66, Issue:8

    Topics: Antibodies, Monoclonal; Autoimmune Diseases; Female; Follow-Up Studies; Humans; Hydrocortisone; Hypo

2013
Thyroid-like ophthalmopathy in a euthyroid patient receiving Ipilimumab.
    Orbit (Amsterdam, Netherlands), 2014, Volume: 33, Issue:6

    Topics: Aged; Antibodies, Monoclonal; Euthyroid Sick Syndromes; Exophthalmos; Female; Glucocorticoids; Grave

2014
Low thyroid hormone levels improve survival in murine model for ocular melanoma.
    Oncotarget, 2015, May-10, Volume: 6, Issue:13

    Topics: Animals; Antithyroid Agents; Disease Models, Animal; Eye Neoplasms; Hyperthyroidism; Hypothyroidism;

2015
Nivolumab-induced thyroid dysfunction.
    Japanese journal of clinical oncology, 2016, Volume: 46, Issue:6

    Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antineoplastic Agents; Female; Hormone Replacement

2016
Risk of cumulative toxicity after complete melanoma response with pembrolizumab.
    BMJ case reports, 2017, Feb-01, Volume: 2017

    Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Drug Eruptions; Groin; Hormone Repla

2017
Effect of thiouracil and thyroxine on development and growth of cutaneous melanoma in killifish hybrids.
    Nature, 1959, Aug-15, Volume: 184(Suppl 8)

    Topics: Animals; Fundulidae; Growth and Development; Melanoma; Melanoma, Cutaneous Malignant; Melanoma, Expe

1959
Accumulation of 125I-labelled thiouracil and propylthiouracil in murine melanotic melanomas.
    British journal of cancer, 1982, Volume: 46, Issue:4

    Topics: Animals; Cells, Cultured; Iodine Radioisotopes; Melanoma; Mice; Mice, Inbred DBA; Neoplasms, Experim

1982
Cutaneous metastasis from follicular carcinoma of the thyroid gland.
    Thyroid : official journal of the American Thyroid Association, 1993,Fall, Volume: 3, Issue:3

    Topics: Adenocarcinoma, Follicular; Aged; Follow-Up Studies; Humans; Iodine Radioisotopes; Male; Melanoma; R

1993
[The effect of L-thyroxine amino acid on human melanoma cell lines].
    Medicina, 1993, Volume: 53, Issue:2

    Topics: Cell Transformation, Neoplastic; Humans; Melanoma; Thyroxine; Tumor Cells, Cultured

1993
Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Aug-01, Volume: 19, Issue:15

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Humans; Inject

2001
Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Aug-01, Volume: 19, Issue:15

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Humans; Inject

2001
Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Aug-01, Volume: 19, Issue:15

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Humans; Inject

2001
Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Aug-01, Volume: 19, Issue:15

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Humans; Inject

2001
3,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells.
    Biochemical and biophysical research communications, 1988, Sep-30, Volume: 155, Issue:3

    Topics: Animals; Catechol Oxidase; Cells, Cultured; Enzyme Induction; Imidazoles; Melanoma; Mice; Monophenol

1988
The effect of large doses of medroxyprogesterone acetate (MPA) on urinary estrogen levels and serum levels of cortisol T4 LH and testosterone in patients with advanced cancer.
    Obstetrics and gynecology, 1974, Volume: 43, Issue:2

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Breast Neoplasms; Dose-Response Relationship, Drug; Estrog

1974