thyroxine has been researched along with Medulloblastoma in 4 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "From Jan 1998 to Feb 2001, a total of 37 euthyroid children scheduled for CSI for medulloblastoma/primitive neuroectodermal tumor underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of CSI." | 3.74 | Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor. ( Biassoni, V; Bombardieri, E; Collini, P; Fossati-Bellani, F; Gandola, L; Marchianò, A; Massimino, M; Pallotti, F; Pignoli, E; Seregni, E; Serra, A; Spreafico, F; Terenziani, M, 2007) |
| "The uptake of 3,5,3'-triiodothyronine (T3) and thyroxine (T4) was studied in human glioma cells (Hs 683) and compared with that in several other neural cell lines." | 3.68 | Thyroid hormone transport in a human glioma cell line. ( Goncalves, E; Lakshmanan, M; Pontecorvi, A; Robbins, J, 1990) |
| "Primary hypothyroidism was diagnosed in 16 group A patients and 4 group B patients, and central hypothyroidism was diagnosed in 2 group A patients (difference in risk of developing hypothyroidism evaluated with a Wilcoxon-test: p=0." | 1.31 | Thyroid diseases in patients treated during pre-puberty for medulloblastoma with different radiotherapic protocols. ( Altare, F; Andreo, M; Artesani, L; Besenzon, L; Corrias, A; De Sanctis, C; Einaudi, S; Genitori, L; Ricardi, U; Sandri, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Massimino, M | 1 |
| Gandola, L | 1 |
| Collini, P | 1 |
| Seregni, E | 1 |
| Marchianò, A | 1 |
| Serra, A | 1 |
| Pignoli, E | 1 |
| Spreafico, F | 1 |
| Pallotti, F | 1 |
| Terenziani, M | 1 |
| Biassoni, V | 1 |
| Bombardieri, E | 1 |
| Fossati-Bellani, F | 1 |
| Corrias, A | 1 |
| Einaudi, S | 1 |
| Ricardi, U | 1 |
| Sandri, A | 1 |
| Besenzon, L | 1 |
| Altare, F | 1 |
| Artesani, L | 1 |
| Genitori, L | 1 |
| Andreo, M | 1 |
| De Sanctis, C | 1 |
| Kanev, PM | 1 |
| Lefebvre, JF | 1 |
| Mauseth, RS | 1 |
| Berger, MS | 1 |
| Goncalves, E | 1 |
| Lakshmanan, M | 1 |
| Pontecorvi, A | 1 |
| Robbins, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Protection From Iatrogenic Hypothyroidism Patients With MBL and Pediatric Patients With HL and Non-HL Needing Radiotherapy on Thyroid Site[NCT05316922] | Phase 3 | 68 participants (Anticipated) | Interventional | 2021-12-13 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for thyroxine and Medulloblastoma
| Article | Year |
|---|---|
Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor.
Topics: Adolescent; Adult; Biomarkers; Brain Neoplasms; Child; Child, Preschool; Cranial Irradiation; Diseas | 2007 |
Thyroid diseases in patients treated during pre-puberty for medulloblastoma with different radiotherapic protocols.
Topics: Adolescent; Biopsy, Needle; Cerebellar Neoplasms; Child; Child, Preschool; Female; Humans; Hypothyro | 2001 |
Growth hormone deficiency following radiation therapy of primary brain tumors in children.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Craniopharyngioma; Ependymoma; Female; Growth | 1991 |
Thyroid hormone transport in a human glioma cell line.
Topics: Aminoisobutyric Acids; Antimycin A; Binding, Competitive; Biological Transport; Cadaverine; Cell Mem | 1990 |