Page last updated: 2024-11-06

thyroxine and Low Bone Density

thyroxine has been researched along with Low Bone Density in 33 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"The effect of subclinical hyperthyroidism on bone mineral density is controversial and could be significant in patients with differentiated thyroid carcinoma who receive suppressive doses of levothyroxine (LT4)."9.11Lack of deleterious effect on bone mineral density of long-term thyroxine suppressive therapy for differentiated thyroid carcinoma. ( Alonso, N; Granada, ML; Holgado, S; Reverter, JL; Salinas, I; Sanmartí, A, 2005)
"The effect of subclinical hyperthyroidism on bone mineral density is controversial and could be significant in patients with differentiated thyroid carcinoma who receive suppressive doses of levothyroxine (LT4)."5.11Lack of deleterious effect on bone mineral density of long-term thyroxine suppressive therapy for differentiated thyroid carcinoma. ( Alonso, N; Granada, ML; Holgado, S; Reverter, JL; Salinas, I; Sanmartí, A, 2005)
"Pain intensity was graded according to 4-score scale, atraumatic fractures in the past were recorded, mineral bone density (MBD) was studied, TTH and T4 levels and biochemical indices of calcium-phosphorus and bone metabolism were studied, thyroid volume was calculated by J."3.73[Features of osteopenic syndrome in diffuse toxic goiter]. ( Davydova, LI; Nekrasova, MR; Suplotova, LA, 2005)
"Although osteoporosis is increasingly shown to occur in a considerable proportion of men, data on risk factors for male osteoporosis are limited."1.36The association between serum thyrotropin (TSH) levels and bone mineral density in healthy euthyroid men. ( Bae, SJ; Choe, JW; Kim, BJ; Kim, GS; Kim, HK; Kim, HY; Koh, JM; Lee, SH, 2010)
"Hypopituitarism is a well-known cause of secondary osteoporosis."1.33High risk of osteopenia and bone derangement in postsurgical patients with craniopharyngiomas, pituitary adenomas and other parasellar lesions. ( Matsuno, A; Okazaki, R; Okinaga, H, 2005)
"Thyrotoxicosis is frequently associated with increased bone turnover and decreased bone mass."1.32Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. ( Bianco, AC; Brent, GA; Freitas, FR; Gouveia, CH; Jorgetti, V; Moriscot, AS; Passarelli, M; Scanlan, TS; Soares, AG, 2003)
"Inflammation-mediated osteopenia (IMO) in the rat is characterized by loss of bone mass within 3 weeks after induction of nonspecific inflammation (s."1.28Effects of endogenous and exogenous calcitonin on inflammation-mediated osteopenia in the rat. ( Ding, G; Minne, HW; Wüster, C; Ziegler, R, 1992)
" It is advisable, therefore, to employ a dosage of L-T4 that is carefully monitored to avoid the long-term use of dosages that are excessive for the thyroid condition being treated."1.27Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women. ( Baran, DT; Braverman, LE; Kelly, AM; Kerrigan, J; Paul, TL, 1988)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19905 (15.15)18.7374
1990's7 (21.21)18.2507
2000's11 (33.33)29.6817
2010's8 (24.24)24.3611
2020's2 (6.06)2.80

Authors

AuthorsStudies
Singh, B1
Hooda, N1
Baidya, S1
Doknic, M1
Gasic, V1
Stojanovic, M1
Pavlovic, S1
Marinkovic, S1
Miljic, D1
Pekic, S1
Manojlovic-Gacic, E1
Damjanovic, D1
Soldatovic, I1
Petakov, M1
Kim, K1
Kim, IJ1
Pak, K1
Kim, SJ1
Shin, S1
Kim, BH1
Kim, SS1
Lee, BJ1
Jeon, YK1
Demirel, U1
Özek, E1
Bereket, A1
Demirel, B1
Topuzoğlu, A1
Akman, İ1
van Rijn, LE1
Pop, VJ1
Williams, GR1
Cruz Grecco Teixeira, MB1
Martins, GM1
Miranda-Rodrigues, M1
De Araújo, IF1
Oliveira, R1
Brum, PC1
Azevedo Gouveia, CH1
Salerno, M1
Capalbo, D1
Cerbone, M1
De Luca, F1
Serakides, R1
Ocarino, Nde M1
Magalhães, Fdo C1
Souza, Cde A1
Leite, ED1
Freitas, ES1
Kim, BJ1
Lee, SH1
Bae, SJ1
Kim, HK1
Choe, JW1
Kim, HY1
Koh, JM1
Kim, GS1
Bours, SP1
van Geel, TA1
Geusens, PP1
Janssen, MJ1
Janzing, HM1
Hoffland, GA1
Willems, PC1
van den Bergh, JP1
Baliram, R1
Sun, L1
Cao, J1
Li, J1
Latif, R1
Huber, AK1
Yuen, T1
Blair, HC1
Zaidi, M1
Davies, TF1
Freitas, FR1
Moriscot, AS1
Jorgetti, V1
Soares, AG1
Passarelli, M1
Scanlan, TS1
Brent, GA1
Bianco, AC1
Gouveia, CH1
Nekrasova, MR1
Suplotova, LA1
Davydova, LI1
Khmara, IM1
Tolkachev, IuV1
Reverter, JL1
Holgado, S1
Alonso, N1
Salinas, I1
Granada, ML1
Sanmartí, A1
Okinaga, H1
Matsuno, A1
Okazaki, R1
Babińska, A1
Wiśniewski, P1
Sworczak, K1
Nigg, C1
Naumann, UK1
Käser, L1
Vetter, W1
Yamamoto, M1
Markatos, A1
Seedor, JG1
Masarachia, P1
Gentile, M1
Rodan, GA1
Balena, R1
De Schepper, J1
Smitz, J1
Dab, I1
Piepsz, A1
Jonckheer, M1
Bergmann, P1
Kaplanskiĭ, AS1
Durnova, GN1
Ili'ina-Kakueva, EI1
Loginov, VI1
Duntas, LH1
Mantzou, E1
Koutras, DA1
Zeni, S1
Gomez-Acotto, C1
Mautalen, C1
Ikeda, H1
Wüster, C1
Ding, G1
Minne, HW1
Ziegler, R1
Sugino, K1
Kure, Y1
Ozaki, O1
Ito, K1
Matsumoto, A1
Lehmke, J1
Bogner, U1
Felsenberg, D1
Peters, H1
Schleusener, H1
Toh, SH1
Brown, PH1
Heath, H1
Paul, TL1
Kerrigan, J1
Kelly, AM1
Braverman, LE1
Baran, DT1
Cooper, DS1
Hirsch, PF1
Hagaman, JR1
Ross, DS1
Neer, RM1
Ridgway, EC1
Daniels, GH1

Reviews

3 reviews available for thyroxine and Low Bone Density

ArticleYear
Subclinical hypothyroidism in childhood - current knowledge and open issues.
    Nature reviews. Endocrinology, 2016, Volume: 12, Issue:12

    Topics: Anticonvulsants; Antiviral Agents; Asymptomatic Diseases; Atherosclerosis; Bone Diseases, Metabolic;

2016
[Contemporary view on subclinical hyperthyroidism].
    Polskie Archiwum Medycyny Wewnetrznej, 2006, Volume: 116, Issue:2

    Topics: Bone Diseases, Metabolic; Causality; Comorbidity; Female; Humans; Hyperthyroidism; Male; Menopause;

2006
[New clinical laboratory tests for endocrine and metabolism disorders].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2001, Nov-10, Volume: 90, Issue:11

    Topics: Adrenomedullin; Atrial Natriuretic Factor; Autoantibodies; Biomarkers; Bone Diseases, Metabolic; Dia

2001

Trials

3 trials available for thyroxine and Low Bone Density

ArticleYear
Lack of deleterious effect on bone mineral density of long-term thyroxine suppressive therapy for differentiated thyroid carcinoma.
    Endocrine-related cancer, 2005, Volume: 12, Issue:4

    Topics: Antineoplastic Agents; Bone Density; Bone Diseases, Metabolic; Carcinoma; Female; Femur Neck; Humans

2005
Lack of substantial effects of raloxifene on thyroxine-binding globulin in postmenopausal women: dependency on thyroid status.
    Thyroid : official journal of the American Thyroid Association, 2001, Volume: 11, Issue:8

    Topics: Aged; Bone Diseases, Metabolic; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Middle A

2001
Bone mineral content in hypothyroid male patients with hormone replacement: a 3-year study.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5, Issue:5

    Topics: Bone Density; Bone Diseases, Metabolic; Bone Resorption; Clinical Trials as Topic; Follow-Up Studies

1990

Other Studies

27 other studies available for thyroxine and Low Bone Density

ArticleYear
Chronic Liver Disease Secondary to Chronic Budd Chiari Causing Osteomalacia Leading to Pathological Fractures.
    The Journal of the Association of Physicians of India, 2023, Volume: 71, Issue:1

    Topics: Adult; Bone Diseases, Metabolic; Calcium; End Stage Liver Disease; Female; Fractures, Multiple; Frac

2023
Hypopituitarism in five PROP1 mutation siblings: long-lasting natural course and the effects of growth hormone replacement introduction in middle adulthood.
    Pituitary, 2020, Volume: 23, Issue:4

    Topics: Absorptiometry, Photon; Adult; Body Composition; Bone Density; Bone Diseases, Metabolic; Brain Neopl

2020
Evaluation of Bone Mineral Density Using DXA and cQCT in Postmenopausal Patients Under Thyrotropin Suppressive Therapy.
    The Journal of clinical endocrinology and metabolism, 2018, 11-01, Volume: 103, Issue:11

    Topics: Absorptiometry, Photon; Bone Density; Bone Diseases, Metabolic; Cross-Sectional Studies; Female; Hum

2018
Does transient hypothyroxinemia influence metabolic bone disease of prematurity?
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:18

    Topics: Birth Weight; Bone Diseases, Metabolic; Congenital Hypothyroidism; Female; Gestational Age; Humans;

2013
Low bone mineral density is related to high physiological levels of free thyroxine in peri-menopausal women.
    European journal of endocrinology, 2014, Volume: 170, Issue:3

    Topics: Bone Density; Bone Diseases, Metabolic; Cross-Sectional Studies; Female; Humans; Iodide Peroxidase;

2014
Lack of α2C-Adrenoceptor Results in Contrasting Phenotypes of Long Bones and Vertebra and Prevents the Thyrotoxicosis-Induced Osteopenia.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Animals; Biomechanical Phenomena; Bone Diseases, Metabolic; Bone Remodeling; Female; Femur; Gene Exp

2016
[Bone histomorphometry of lactating and no lactating hyperthyroid rats].
    Arquivos brasileiros de endocrinologia e metabologia, 2008, Volume: 52, Issue:4

    Topics: Animals; Bone Diseases, Metabolic; Female; Hyperthyroidism; Lactation; Rats; Rats, Wistar; Risk Fact

2008
The association between serum thyrotropin (TSH) levels and bone mineral density in healthy euthyroid men.
    Clinical endocrinology, 2010, Volume: 73, Issue:3

    Topics: Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Analysis of Variance;

2010
Contributors to secondary osteoporosis and metabolic bone diseases in patients presenting with a clinical fracture.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:5

    Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Bone Density; Bone Diseases, Metabolic; Calcium; Crea

2011
Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:10

    Topics: Animals; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Dose-Response Relationship, Drug;

2012
Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1.
    American journal of physiology. Endocrinology and metabolism, 2003, Volume: 285, Issue:5

    Topics: Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Cholesterol; Female; Femur; Rats; Rats

2003
[Features of osteopenic syndrome in diffuse toxic goiter].
    Terapevticheskii arkhiv, 2005, Volume: 77, Issue:10

    Topics: Adult; Aged; Bone Density; Bone Diseases, Metabolic; Calcium; Case-Control Studies; Densitometry; Fe

2005
[Bone tissue mineral density in patients with thyroid gland cancer on levothyroxine natrium therapy].
    Klinicheskaia meditsina, 2005, Volume: 83, Issue:10

    Topics: Absorptiometry, Photon; Adolescent; Adult; Bone Density; Bone Diseases, Metabolic; Calcium; Chi-Squa

2005
High risk of osteopenia and bone derangement in postsurgical patients with craniopharyngiomas, pituitary adenomas and other parasellar lesions.
    Endocrine journal, 2005, Volume: 52, Issue:6

    Topics: Adolescent; Adult; Aged; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Child; Collagen; C

2005
[Anorexia nervosa]].
    Praxis, 2007, Mar-21, Volume: 96, Issue:12

    Topics: Adult; Amenorrhea; Anorexia Nervosa; Body Image; Bone Diseases, Metabolic; Female; Humans; Hyperthyr

2007
The effects of the aminobisphosphonate alendronate on thyroid hormone-induced osteopenia in rats.
    Calcified tissue international, 1993, Volume: 53, Issue:4

    Topics: Alendronate; Animals; Bone Diseases, Metabolic; Bone Remodeling; Bone Resorption; Diphosphonates; Di

1993
Low serum bone gamma-carboxyglutamic acid protein concentrations in patients with cystic fibrosis: correlation with hormonal parameters and bone mineral density.
    Hormone research, 1993, Volume: 39, Issue:5-6

    Topics: Adolescent; Bone Density; Bone Diseases, Metabolic; Calcifediol; Child; Child, Preschool; Cystic Fib

1993
[Role of growth hormone underproduction and support load deficit in development of muscle atrophy and osteopenia in tail-suspended rats].
    Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine, 1999, Volume: 33, Issue:1

    Topics: Animals; Bone Diseases, Metabolic; Disease Models, Animal; Follow-Up Studies; Growth Hormone; Hindli

1999
Do different aminobisphosphonates have similar preventive effect on experimental thyroid hormone-induced osteopenia in rats?
    Calcified tissue international, 2001, Volume: 69, Issue:5

    Topics: Alendronate; Animals; Body Weight; Bone Diseases, Metabolic; Diphosphonates; Female; Pamidronate; Ra

2001
Effects of endogenous and exogenous calcitonin on inflammation-mediated osteopenia in the rat.
    Hormone research, 1992, Volume: 37, Issue:3

    Topics: Animals; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Calcitonin; Calcium; Densitometry;

1992
[Does L-thyroxine administration in a dose to suppress TSH secretion induce metabolic bone disturbance in patients with thyroid carcinoma?].
    Nihon Geka Gakkai zasshi, 1992, Volume: 93, Issue:7

    Topics: Adenocarcinoma; Adult; Bone Density; Bone Diseases, Metabolic; Carcinoma, Papillary; Female; Humans;

1992
Determination of bone mineral density by quantitative computed tomography and single photon absorptiometry in subclinical hyperthyroidism: a risk of early osteopaenia in post-menopausal women.
    Clinical endocrinology, 1992, Volume: 36, Issue:5

    Topics: Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Bone Density; Bone Diseases, Metabolic; Calc

1992
Thyroxine replacement therapy and bone mineral density.
    Mayo Clinic proceedings, 1989, Volume: 64, Issue:2

    Topics: Bone Diseases, Metabolic; Humans; Minerals; Thyroxine

1989
Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women.
    JAMA, 1988, Jun-03, Volume: 259, Issue:21

    Topics: Adult; Age Factors; Bone Diseases, Metabolic; Female; Femur; Femur Neck; Humans; Lumbar Vertebrae; M

1988
Thyroid hormone and the skeleton: a bone of contention.
    JAMA, 1988, Jun-03, Volume: 259, Issue:21

    Topics: Bone Diseases, Metabolic; Female; Humans; Thyrotropin; Thyroxine

1988
Reduced bone mass in calcitonin-deficient rats whether lactating or not.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1986, Volume: 1, Issue:2

    Topics: Animals; Body Weight; Bone Diseases, Metabolic; Calcitonin; Calcium; Female; Lactation; Organ Size;

1986
Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine.
    The American journal of medicine, 1987, Volume: 82, Issue:6

    Topics: Adult; Bone Diseases, Metabolic; Depression, Chemical; Female; Humans; Hyperthyroidism; Pituitary Gl

1987