thyroxine has been researched along with Low Bone Density in 33 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of subclinical hyperthyroidism on bone mineral density is controversial and could be significant in patients with differentiated thyroid carcinoma who receive suppressive doses of levothyroxine (LT4)." | 9.11 | Lack of deleterious effect on bone mineral density of long-term thyroxine suppressive therapy for differentiated thyroid carcinoma. ( Alonso, N; Granada, ML; Holgado, S; Reverter, JL; Salinas, I; Sanmartí, A, 2005) |
| "The effect of subclinical hyperthyroidism on bone mineral density is controversial and could be significant in patients with differentiated thyroid carcinoma who receive suppressive doses of levothyroxine (LT4)." | 5.11 | Lack of deleterious effect on bone mineral density of long-term thyroxine suppressive therapy for differentiated thyroid carcinoma. ( Alonso, N; Granada, ML; Holgado, S; Reverter, JL; Salinas, I; Sanmartí, A, 2005) |
| "Pain intensity was graded according to 4-score scale, atraumatic fractures in the past were recorded, mineral bone density (MBD) was studied, TTH and T4 levels and biochemical indices of calcium-phosphorus and bone metabolism were studied, thyroid volume was calculated by J." | 3.73 | [Features of osteopenic syndrome in diffuse toxic goiter]. ( Davydova, LI; Nekrasova, MR; Suplotova, LA, 2005) |
| "Although osteoporosis is increasingly shown to occur in a considerable proportion of men, data on risk factors for male osteoporosis are limited." | 1.36 | The association between serum thyrotropin (TSH) levels and bone mineral density in healthy euthyroid men. ( Bae, SJ; Choe, JW; Kim, BJ; Kim, GS; Kim, HK; Kim, HY; Koh, JM; Lee, SH, 2010) |
| "Hypopituitarism is a well-known cause of secondary osteoporosis." | 1.33 | High risk of osteopenia and bone derangement in postsurgical patients with craniopharyngiomas, pituitary adenomas and other parasellar lesions. ( Matsuno, A; Okazaki, R; Okinaga, H, 2005) |
| "Thyrotoxicosis is frequently associated with increased bone turnover and decreased bone mass." | 1.32 | Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. ( Bianco, AC; Brent, GA; Freitas, FR; Gouveia, CH; Jorgetti, V; Moriscot, AS; Passarelli, M; Scanlan, TS; Soares, AG, 2003) |
| "Inflammation-mediated osteopenia (IMO) in the rat is characterized by loss of bone mass within 3 weeks after induction of nonspecific inflammation (s." | 1.28 | Effects of endogenous and exogenous calcitonin on inflammation-mediated osteopenia in the rat. ( Ding, G; Minne, HW; Wüster, C; Ziegler, R, 1992) |
| " It is advisable, therefore, to employ a dosage of L-T4 that is carefully monitored to avoid the long-term use of dosages that are excessive for the thyroid condition being treated." | 1.27 | Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women. ( Baran, DT; Braverman, LE; Kelly, AM; Kerrigan, J; Paul, TL, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.15) | 18.7374 |
| 1990's | 7 (21.21) | 18.2507 |
| 2000's | 11 (33.33) | 29.6817 |
| 2010's | 8 (24.24) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, B | 1 |
| Hooda, N | 1 |
| Baidya, S | 1 |
| Doknic, M | 1 |
| Gasic, V | 1 |
| Stojanovic, M | 1 |
| Pavlovic, S | 1 |
| Marinkovic, S | 1 |
| Miljic, D | 1 |
| Pekic, S | 1 |
| Manojlovic-Gacic, E | 1 |
| Damjanovic, D | 1 |
| Soldatovic, I | 1 |
| Petakov, M | 1 |
| Kim, K | 1 |
| Kim, IJ | 1 |
| Pak, K | 1 |
| Kim, SJ | 1 |
| Shin, S | 1 |
| Kim, BH | 1 |
| Kim, SS | 1 |
| Lee, BJ | 1 |
| Jeon, YK | 1 |
| Demirel, U | 1 |
| Özek, E | 1 |
| Bereket, A | 1 |
| Demirel, B | 1 |
| Topuzoğlu, A | 1 |
| Akman, İ | 1 |
| van Rijn, LE | 1 |
| Pop, VJ | 1 |
| Williams, GR | 1 |
| Cruz Grecco Teixeira, MB | 1 |
| Martins, GM | 1 |
| Miranda-Rodrigues, M | 1 |
| De Araújo, IF | 1 |
| Oliveira, R | 1 |
| Brum, PC | 1 |
| Azevedo Gouveia, CH | 1 |
| Salerno, M | 1 |
| Capalbo, D | 1 |
| Cerbone, M | 1 |
| De Luca, F | 1 |
| Serakides, R | 1 |
| Ocarino, Nde M | 1 |
| Magalhães, Fdo C | 1 |
| Souza, Cde A | 1 |
| Leite, ED | 1 |
| Freitas, ES | 1 |
| Kim, BJ | 1 |
| Lee, SH | 1 |
| Bae, SJ | 1 |
| Kim, HK | 1 |
| Choe, JW | 1 |
| Kim, HY | 1 |
| Koh, JM | 1 |
| Kim, GS | 1 |
| Bours, SP | 1 |
| van Geel, TA | 1 |
| Geusens, PP | 1 |
| Janssen, MJ | 1 |
| Janzing, HM | 1 |
| Hoffland, GA | 1 |
| Willems, PC | 1 |
| van den Bergh, JP | 1 |
| Baliram, R | 1 |
| Sun, L | 1 |
| Cao, J | 1 |
| Li, J | 1 |
| Latif, R | 1 |
| Huber, AK | 1 |
| Yuen, T | 1 |
| Blair, HC | 1 |
| Zaidi, M | 1 |
| Davies, TF | 1 |
| Freitas, FR | 1 |
| Moriscot, AS | 1 |
| Jorgetti, V | 1 |
| Soares, AG | 1 |
| Passarelli, M | 1 |
| Scanlan, TS | 1 |
| Brent, GA | 1 |
| Bianco, AC | 1 |
| Gouveia, CH | 1 |
| Nekrasova, MR | 1 |
| Suplotova, LA | 1 |
| Davydova, LI | 1 |
| Khmara, IM | 1 |
| Tolkachev, IuV | 1 |
| Reverter, JL | 1 |
| Holgado, S | 1 |
| Alonso, N | 1 |
| Salinas, I | 1 |
| Granada, ML | 1 |
| Sanmartí, A | 1 |
| Okinaga, H | 1 |
| Matsuno, A | 1 |
| Okazaki, R | 1 |
| Babińska, A | 1 |
| Wiśniewski, P | 1 |
| Sworczak, K | 1 |
| Nigg, C | 1 |
| Naumann, UK | 1 |
| Käser, L | 1 |
| Vetter, W | 1 |
| Yamamoto, M | 1 |
| Markatos, A | 1 |
| Seedor, JG | 1 |
| Masarachia, P | 1 |
| Gentile, M | 1 |
| Rodan, GA | 1 |
| Balena, R | 1 |
| De Schepper, J | 1 |
| Smitz, J | 1 |
| Dab, I | 1 |
| Piepsz, A | 1 |
| Jonckheer, M | 1 |
| Bergmann, P | 1 |
| Kaplanskiĭ, AS | 1 |
| Durnova, GN | 1 |
| Ili'ina-Kakueva, EI | 1 |
| Loginov, VI | 1 |
| Duntas, LH | 1 |
| Mantzou, E | 1 |
| Koutras, DA | 1 |
| Zeni, S | 1 |
| Gomez-Acotto, C | 1 |
| Mautalen, C | 1 |
| Ikeda, H | 1 |
| Wüster, C | 1 |
| Ding, G | 1 |
| Minne, HW | 1 |
| Ziegler, R | 1 |
| Sugino, K | 1 |
| Kure, Y | 1 |
| Ozaki, O | 1 |
| Ito, K | 1 |
| Matsumoto, A | 1 |
| Lehmke, J | 1 |
| Bogner, U | 1 |
| Felsenberg, D | 1 |
| Peters, H | 1 |
| Schleusener, H | 1 |
| Toh, SH | 1 |
| Brown, PH | 1 |
| Heath, H | 1 |
| Paul, TL | 1 |
| Kerrigan, J | 1 |
| Kelly, AM | 1 |
| Braverman, LE | 1 |
| Baran, DT | 1 |
| Cooper, DS | 1 |
| Hirsch, PF | 1 |
| Hagaman, JR | 1 |
| Ross, DS | 1 |
| Neer, RM | 1 |
| Ridgway, EC | 1 |
| Daniels, GH | 1 |
3 reviews available for thyroxine and Low Bone Density
| Article | Year |
|---|---|
Subclinical hypothyroidism in childhood - current knowledge and open issues.
Topics: Anticonvulsants; Antiviral Agents; Asymptomatic Diseases; Atherosclerosis; Bone Diseases, Metabolic; | 2016 |
[Contemporary view on subclinical hyperthyroidism].
Topics: Bone Diseases, Metabolic; Causality; Comorbidity; Female; Humans; Hyperthyroidism; Male; Menopause; | 2006 |
[New clinical laboratory tests for endocrine and metabolism disorders].
Topics: Adrenomedullin; Atrial Natriuretic Factor; Autoantibodies; Biomarkers; Bone Diseases, Metabolic; Dia | 2001 |
3 trials available for thyroxine and Low Bone Density
| Article | Year |
|---|---|
Lack of deleterious effect on bone mineral density of long-term thyroxine suppressive therapy for differentiated thyroid carcinoma.
Topics: Antineoplastic Agents; Bone Density; Bone Diseases, Metabolic; Carcinoma; Female; Femur Neck; Humans | 2005 |
Lack of substantial effects of raloxifene on thyroxine-binding globulin in postmenopausal women: dependency on thyroid status.
Topics: Aged; Bone Diseases, Metabolic; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Middle A | 2001 |
Bone mineral content in hypothyroid male patients with hormone replacement: a 3-year study.
Topics: Bone Density; Bone Diseases, Metabolic; Bone Resorption; Clinical Trials as Topic; Follow-Up Studies | 1990 |
27 other studies available for thyroxine and Low Bone Density
| Article | Year |
|---|---|
Chronic Liver Disease Secondary to Chronic Budd Chiari Causing Osteomalacia Leading to Pathological Fractures.
Topics: Adult; Bone Diseases, Metabolic; Calcium; End Stage Liver Disease; Female; Fractures, Multiple; Frac | 2023 |
Hypopituitarism in five PROP1 mutation siblings: long-lasting natural course and the effects of growth hormone replacement introduction in middle adulthood.
Topics: Absorptiometry, Photon; Adult; Body Composition; Bone Density; Bone Diseases, Metabolic; Brain Neopl | 2020 |
Evaluation of Bone Mineral Density Using DXA and cQCT in Postmenopausal Patients Under Thyrotropin Suppressive Therapy.
Topics: Absorptiometry, Photon; Bone Density; Bone Diseases, Metabolic; Cross-Sectional Studies; Female; Hum | 2018 |
Does transient hypothyroxinemia influence metabolic bone disease of prematurity?
Topics: Birth Weight; Bone Diseases, Metabolic; Congenital Hypothyroidism; Female; Gestational Age; Humans; | 2013 |
Low bone mineral density is related to high physiological levels of free thyroxine in peri-menopausal women.
Topics: Bone Density; Bone Diseases, Metabolic; Cross-Sectional Studies; Female; Humans; Iodide Peroxidase; | 2014 |
Lack of α2C-Adrenoceptor Results in Contrasting Phenotypes of Long Bones and Vertebra and Prevents the Thyrotoxicosis-Induced Osteopenia.
Topics: Animals; Biomechanical Phenomena; Bone Diseases, Metabolic; Bone Remodeling; Female; Femur; Gene Exp | 2016 |
[Bone histomorphometry of lactating and no lactating hyperthyroid rats].
Topics: Animals; Bone Diseases, Metabolic; Female; Hyperthyroidism; Lactation; Rats; Rats, Wistar; Risk Fact | 2008 |
The association between serum thyrotropin (TSH) levels and bone mineral density in healthy euthyroid men.
Topics: Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Analysis of Variance; | 2010 |
Contributors to secondary osteoporosis and metabolic bone diseases in patients presenting with a clinical fracture.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Bone Density; Bone Diseases, Metabolic; Calcium; Crea | 2011 |
Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling.
Topics: Animals; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Dose-Response Relationship, Drug; | 2012 |
Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1.
Topics: Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Cholesterol; Female; Femur; Rats; Rats | 2003 |
[Features of osteopenic syndrome in diffuse toxic goiter].
Topics: Adult; Aged; Bone Density; Bone Diseases, Metabolic; Calcium; Case-Control Studies; Densitometry; Fe | 2005 |
[Bone tissue mineral density in patients with thyroid gland cancer on levothyroxine natrium therapy].
Topics: Absorptiometry, Photon; Adolescent; Adult; Bone Density; Bone Diseases, Metabolic; Calcium; Chi-Squa | 2005 |
High risk of osteopenia and bone derangement in postsurgical patients with craniopharyngiomas, pituitary adenomas and other parasellar lesions.
Topics: Adolescent; Adult; Aged; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Child; Collagen; C | 2005 |
[Anorexia nervosa]].
Topics: Adult; Amenorrhea; Anorexia Nervosa; Body Image; Bone Diseases, Metabolic; Female; Humans; Hyperthyr | 2007 |
The effects of the aminobisphosphonate alendronate on thyroid hormone-induced osteopenia in rats.
Topics: Alendronate; Animals; Bone Diseases, Metabolic; Bone Remodeling; Bone Resorption; Diphosphonates; Di | 1993 |
Low serum bone gamma-carboxyglutamic acid protein concentrations in patients with cystic fibrosis: correlation with hormonal parameters and bone mineral density.
Topics: Adolescent; Bone Density; Bone Diseases, Metabolic; Calcifediol; Child; Child, Preschool; Cystic Fib | 1993 |
[Role of growth hormone underproduction and support load deficit in development of muscle atrophy and osteopenia in tail-suspended rats].
Topics: Animals; Bone Diseases, Metabolic; Disease Models, Animal; Follow-Up Studies; Growth Hormone; Hindli | 1999 |
Do different aminobisphosphonates have similar preventive effect on experimental thyroid hormone-induced osteopenia in rats?
Topics: Alendronate; Animals; Body Weight; Bone Diseases, Metabolic; Diphosphonates; Female; Pamidronate; Ra | 2001 |
Effects of endogenous and exogenous calcitonin on inflammation-mediated osteopenia in the rat.
Topics: Animals; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Calcitonin; Calcium; Densitometry; | 1992 |
[Does L-thyroxine administration in a dose to suppress TSH secretion induce metabolic bone disturbance in patients with thyroid carcinoma?].
Topics: Adenocarcinoma; Adult; Bone Density; Bone Diseases, Metabolic; Carcinoma, Papillary; Female; Humans; | 1992 |
Determination of bone mineral density by quantitative computed tomography and single photon absorptiometry in subclinical hyperthyroidism: a risk of early osteopaenia in post-menopausal women.
Topics: Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Bone Density; Bone Diseases, Metabolic; Calc | 1992 |
Thyroxine replacement therapy and bone mineral density.
Topics: Bone Diseases, Metabolic; Humans; Minerals; Thyroxine | 1989 |
Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women.
Topics: Adult; Age Factors; Bone Diseases, Metabolic; Female; Femur; Femur Neck; Humans; Lumbar Vertebrae; M | 1988 |
Thyroid hormone and the skeleton: a bone of contention.
Topics: Bone Diseases, Metabolic; Female; Humans; Thyrotropin; Thyroxine | 1988 |
Reduced bone mass in calcitonin-deficient rats whether lactating or not.
Topics: Animals; Body Weight; Bone Diseases, Metabolic; Calcitonin; Calcium; Female; Lactation; Organ Size; | 1986 |
Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine.
Topics: Adult; Bone Diseases, Metabolic; Depression, Chemical; Female; Humans; Hyperthyroidism; Pituitary Gl | 1987 |