Page last updated: 2024-11-06

thyroxine and Lassitude

thyroxine has been researched along with Lassitude in 76 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"L-Thyroxine is one of the most commonly prescribed drugs and accordingly used by many breast cancer patients with thyroid disorders."7.88L-Thyroxine intake as a potential risk factor for the development of fatigue in breast cancer patients undergoing chemotherapy. ( Habermann, N; Johnson, T; Schmidt, ME; Schneeweiss, A; Steindorf, K; Wiskemann, J, 2018)
"Using observational data collected between January 2006 and March 2014 on a volunteer sample of 602 men and women aged 68-97 years with normal thyroid function participating in the Baltimore Longitudinal Study of Aging, this study examines the concurrent relationship between reported walking ability, usual and rapid gait speed, endurance walk performance, fatigability, and reported energy level with respect to free thyroxine (FT4) within the normal range (0."7.83Free Thyroxine and Functional Mobility, Fitness, and Fatigue in Euthyroid Older Men and Women in the Baltimore Longitudinal Study of Aging. ( Chia, CW; Egan, JM; Ferrucci, L; Mammen, JS; Simonsick, EM, 2016)
"The aim of this study was to evaluate the fatigue perception, the muscle function, and the health-related quality of life (QoL) in subclinical hyperthyroidism (SCH) induced by levothyroxine in the treatment of differentiated thyroid carcinoma, in comparison with a group of euthyroid (EU) subjects."7.79Quality of life, muscle strength, and fatigue perception in patients on suppressive therapy with levothyroxine for differentiated thyroid carcinoma. ( de Castro, CL; de Oliveira Chachamovitz, DS; dos Santos Teixeira, Pde F; dos Santos Vigário, P; Nogueira Cordeiro, MF; Vaisman, M, 2013)
"Patients with documented metastatic colorectal cancer and progression of disease during or within 3 months after the last standard therapy, with no evidence and history of previous thyroid disease were enrolled."5.46Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link? ( Madeddu, C; Mariotti, S; Massa, E; Massidda, M; Pani, F; Pusceddu, V; Puzzoni, M; Scartozzi, M, 2017)
"Fatigue was evaluated by the RAND-36 and the shortened fatigue questionnaire (SFQ)."5.38Is there a relationship between fatigue perception and the serum levels of thyrotropin and free thyroxine in euthyroid subjects? ( de Vegt, F; den Heijer, M; Hermus, AR; Kiemeney, LA; Netea-Maier, RT; Ross, HA; Sweep, FC; van de Ven, AC, 2012)
"Levothyroxine in older adults with mild subclinical hypothyroidism provides no change in physical or mental fatigability."5.34Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial. ( Aujesky, D; Bauer, DC; Blum, MR; Collet, TH; Del Giovane, C; Feller, M; Glynn, NW; Gussekloo, J; Kearney, PM; McCarthy, VJC; Mooijaart, SP; Moutzouri, E; Rodondi, N; Stott, DJ; Stuber, MJ; Westendorp, R, 2020)
"Hypothyroidism is a relative state, long associated with fatigue and depression."5.30Experiences of fatigue and depression before and after low-dose 1-thyroxine supplementation in essentially euthyroid individuals. ( Dzurec, LC, 1997)
"The use of levothyroxine to treat subclinical hypothyroidism is controversial."5.24Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. ( Aubert, CE; Aujesky, D; Bauer, DC; Baumgartner, C; Blum, MR; Browne, JP; Byrne, S; Collet, TH; Dekkers, OM; den Elzen, WPJ; Du Puy, RS; Ellis, G; Feller, M; Floriani, C; Ford, I; Gussekloo, J; Hendry, K; Hurley, C; Jukema, JW; Kean, S; Kearney, PM; Kelly, M; Krebs, D; Langhorne, P; McCarthy, G; McCarthy, V; McConnachie, A; McDade, M; Messow, M; Mooijaart, SP; O'Flynn, A; O'Riordan, D; Poortvliet, RKE; Quinn, TJ; Rodondi, N; Russell, A; Sattar, N; Sinnott, C; Smit, JWA; Stott, DJ; Van Dorland, HA; Walsh, EK; Walsh, KA; Watt, T; Westendorp, RGJ; Wilson, R, 2017)
"L-Thyroxine is one of the most commonly prescribed drugs and accordingly used by many breast cancer patients with thyroid disorders."3.88L-Thyroxine intake as a potential risk factor for the development of fatigue in breast cancer patients undergoing chemotherapy. ( Habermann, N; Johnson, T; Schmidt, ME; Schneeweiss, A; Steindorf, K; Wiskemann, J, 2018)
"Using observational data collected between January 2006 and March 2014 on a volunteer sample of 602 men and women aged 68-97 years with normal thyroid function participating in the Baltimore Longitudinal Study of Aging, this study examines the concurrent relationship between reported walking ability, usual and rapid gait speed, endurance walk performance, fatigability, and reported energy level with respect to free thyroxine (FT4) within the normal range (0."3.83Free Thyroxine and Functional Mobility, Fitness, and Fatigue in Euthyroid Older Men and Women in the Baltimore Longitudinal Study of Aging. ( Chia, CW; Egan, JM; Ferrucci, L; Mammen, JS; Simonsick, EM, 2016)
" The Zhongshan Station crew experienced significant increases in fatigue, anger, tension, confusion, and decrease in free thyroxine (FT4), norepinephrine (NE), and epinephrine (E) during the winter, increase in thyrotropin (TSH) and total triiodothyronine (TT3) when returning, whereas their counterparts at Great Wall Station only experienced increased TT3 after deployment."3.83Different adaptations of Chinese winter-over expeditioners during prolonged Antarctic and sub-Antarctic residence. ( Chen, N; Li, H; Wu, Q; Xu, C; Zhang, T, 2016)
"Thyroid dysfunction in adolescents treated with minocycline for acne has been previously described as transient effect and/or associated with autoimmune thyroiditis."3.83Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth. ( Allen, DB; Pollock, AJ; Seibert, T, 2016)
"The aim of this study was to evaluate the fatigue perception, the muscle function, and the health-related quality of life (QoL) in subclinical hyperthyroidism (SCH) induced by levothyroxine in the treatment of differentiated thyroid carcinoma, in comparison with a group of euthyroid (EU) subjects."3.79Quality of life, muscle strength, and fatigue perception in patients on suppressive therapy with levothyroxine for differentiated thyroid carcinoma. ( de Castro, CL; de Oliveira Chachamovitz, DS; dos Santos Teixeira, Pde F; dos Santos Vigário, P; Nogueira Cordeiro, MF; Vaisman, M, 2013)
"We studied the clinical and hormonal profiles of patients with central hypothyroidism (CH), the adequacy of levothyroxine (L-T4) treatment and the influence of other pituitary hormone replacement therapies."3.72Clinical and hormonal characteristics of central hypothyroidism at diagnosis and during follow-up in adult patients. ( Alexopoulou, O; Beguin, C; De Nayer, P; Maiter, D, 2004)
"Hashimoto disease is a chronic autoimmune thyroiditis."2.90Thyroidectomy Versus Medical Management for Euthyroid Patients With Hashimoto Disease and Persisting Symptoms: A Randomized Trial. ( Bernklev, T; Carlsen, E; Gibbs, C; Guldvog, I; Hoff, G; Johnsen, L; Kvaløy, JT; Lauzike, A; Lende, TH; Narvestad, JK; Omdal, R; Reitsma, LC; Søiland, H, 2019)
"Subclinical hyperthyroidism is associated with atrial fibrillation, osteoporosis and dementia."2.42[Subclinical functional disorders of the thyroid gland]. ( Corssmit, EP; Wiersinga, WM, 2003)
"Symptoms of long COVID are complex and long-lasting, and endocrine dysfunction might be involved in the underlying mechanisms."1.72Hormonal trends in patients suffering from long COVID symptoms. ( Hagiya, H; Hanayama, Y; Hasegawa, T; Honda, H; Kataoka, H; Matsuda, Y; Nakano, Y; Obika, M; Otsuka, F; Otsuka, Y; Sakurada, Y; Sunada, N; Tokumasu, K; Ueda, K; Yamamoto, K, 2022)
"The association between fT4 and frailty was absent in our observational study."1.72Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study. ( Cao, J; Fan, L; Guan, B; Huang, X; Liu, R; Luo, J; Ma, Y; Sun, S; Tian, F; Yu, Y, 2022)
"Hypothyroidism is diagnosed on the basis of laboratory tests because of the lack of specificity of the typical clinical manifestations."1.62Severe primary hypothyroidism in an apparently asymptomatic 19-year-old woman: a case report. ( Aljenaee, K; Dannan, R; Hajji, S, 2021)
"In children with joint hypermobility grade II there was a higher incidence of dentofacial anomalies (χ2 = 6."1.56ENDOCRINE REGULATION OF ERYTHROID LINEAGE OF HEMATOPOIESIS IN CHILDREN LIVING UNDER A LOW-DOSE RADIATION EXPOSURE AFTER THE CHORNOBYL NPP ACCIDENT. ( Bebeshko, VG; Boyarska, OY; Bruslova, KM; Chernysh, TO; Gonchar, LO; Lyashenko, LO; Pismenniy, VD; Trychlib, IV; Tsvyetkova, NM; Vasylenko, VV; Yaroshenko, ZS, 2020)
"We report a rare case of giant prolactinoma with a first epileptic seizure immediately after the initiation of dopamine agonist therapy."1.51Status epilepticus induced by treatment with dopamine agonist therapy for giant prolactinoma: a case report. ( Abe, T; Ebashi, R; Koguchi, M; Masuoka, J; Nakahara, Y; Ogata, A; Shimokawa, S, 2019)
"Patients with documented metastatic colorectal cancer and progression of disease during or within 3 months after the last standard therapy, with no evidence and history of previous thyroid disease were enrolled."1.46Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link? ( Madeddu, C; Mariotti, S; Massa, E; Massidda, M; Pani, F; Pusceddu, V; Puzzoni, M; Scartozzi, M, 2017)
"Methimazole 10 mg/day was started."1.43Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report. ( Carvalho, D; Cunha, FM; Oliveira, J; Rodrigues, E; Saavedra, A; Vinhas, LS, 2016)
"Herein we report a rare case of acquired palmoplantar keratoderma in association with myxoedema and hypothyroidism."1.40[Palmoplantar keratoderma: a rare manifestation of myxoedema]. ( Addi, H; Benchikhi, H; Bouras, M; Farouki, A; Hali, F; Khadir, K, 2014)
"We report on three cases of autoimmune thyroiditis (AT) in young children who presented with constipation, decreased appetite, and increased hours of sleep."1.39Rare cases of autoimmune hypothyroidism in young children. ( Caiulo, S; Chiumello, G; Di Frenna, M; Tronconi, GM; Vigone, MC; Weber, G, 2013)
"Fatigue was evaluated by the RAND-36 and the shortened fatigue questionnaire (SFQ)."1.38Is there a relationship between fatigue perception and the serum levels of thyrotropin and free thyroxine in euthyroid subjects? ( de Vegt, F; den Heijer, M; Hermus, AR; Kiemeney, LA; Netea-Maier, RT; Ross, HA; Sweep, FC; van de Ven, AC, 2012)
"Laboratory tests revealed a primary hypothyroidism with circulating auto-antibodies against thyroid peroxidase (TPO), anaemia and an elevated level of creatine kinase (CK)."1.35[Clinical reasoning and decision making in clinical practice: a boy with fatigue and abdominal pain]. ( Draaisma, JM; Hart, WP; Noordam, C; van Os, E, 2009)
"We report on a 19-year-old woman with polyglandular autoimmune syndrome type II (APS II)."1.35[19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)]. ( Brändle, M; Kehl, O; Lipowsky, C; Schorl-Schweikardt, BA, 2008)
"This is a very rare case of Sheehan's syndrome because the diagnosis was delayed for 27 years after delivery, and it was associated with pancytopenia."1.32Sheehan's syndrome associated with pancytopenia due to marrow aplasia; full recovery with hormone replacement therapy. ( Cevikol, C; Karadogan, I; Karayalcin, U; Ozdogan, M; Undar, L; Yazicioglu, G, 2004)
"High levels of tension-anxiety and confusion were preceded by declines in free T3 and T4."1.31Circannual pattern of hypothalamic-pituitary-thyroid (HPT) function and mood during extended antarctic residence. ( Case, HS; Do, NV; Finney, NS; Palinkas, LA; Reed, HL; Reedy, KR, 2001)
"Hypothyroidism is a relative state, long associated with fatigue and depression."1.30Experiences of fatigue and depression before and after low-dose 1-thyroxine supplementation in essentially euthyroid individuals. ( Dzurec, LC, 1997)
"Pseudohypothyroidism is a prevalent "non-disease" that represents an erroneous diagnosis of hypothyroidism."1.27Pseudohypothyroidism. Differentiation from true hypothyroidism. ( Schneeberg, NG, 1986)

Research

Studies (76)

TimeframeStudies, this research(%)All Research%
pre-19907 (9.21)18.7374
1990's3 (3.95)18.2507
2000's26 (34.21)29.6817
2010's32 (42.11)24.3611
2020's8 (10.53)2.80

Authors

AuthorsStudies
Sunada, N1
Honda, H1
Nakano, Y1
Yamamoto, K1
Tokumasu, K1
Sakurada, Y1
Matsuda, Y1
Hasegawa, T1
Otsuka, Y1
Obika, M1
Hanayama, Y1
Hagiya, H1
Ueda, K1
Kataoka, H1
Otsuka, F1
Guan, B3
Luo, J3
Huang, X3
Tian, F3
Sun, S3
Ma, Y3
Yu, Y3
Liu, R3
Cao, J3
Fan, L3
Bebeshko, VG2
Bruslova, KM2
Volodina, TT1
Lyashenko, LO2
Tsvetkova, NM1
Trychlib, IV2
Chernysh, TO2
Boyarskiy, VG1
Gonchar, LO2
Kavardakova, NV1
Kupchik, N1
Green, J1
van der Gaag, E1
van der Palen, J1
Schaap, P1
van Voorthuizen, M1
Hummel, T1
Stuber, MJ1
Moutzouri, E2
Feller, M3
Del Giovane, C1
Bauer, DC2
Blum, MR2
Collet, TH2
Gussekloo, J2
Mooijaart, SP2
McCarthy, VJC1
Aujesky, D2
Westendorp, R1
Stott, DJ2
Glynn, NW1
Kearney, PM2
Rodondi, N3
Boyarska, OY1
Tsvyetkova, NM1
Pismenniy, VD1
Yaroshenko, ZS1
Vasylenko, VV1
Triano, MJ1
Haberstroh, WD1
Lenka, A1
Whelton, SA1
Dannan, R1
Hajji, S1
Aljenaee, K1
Ford, I1
Westendorp, RGJ1
Sattar, N1
Aubert, CE1
Baumgartner, C1
Browne, JP1
Byrne, S1
Dekkers, OM1
den Elzen, WPJ1
Du Puy, RS1
Ellis, G1
Floriani, C1
Hendry, K1
Hurley, C1
Jukema, JW1
Kean, S1
Kelly, M1
Krebs, D1
Langhorne, P1
McCarthy, G1
McCarthy, V1
McConnachie, A1
McDade, M1
Messow, M1
O'Flynn, A1
O'Riordan, D1
Poortvliet, RKE1
Quinn, TJ1
Russell, A1
Sinnott, C1
Smit, JWA1
Van Dorland, HA1
Walsh, KA1
Walsh, EK1
Watt, T1
Wilson, R1
Pani, F1
Massidda, M1
Pusceddu, V1
Puzzoni, M1
Massa, E1
Madeddu, C1
Scartozzi, M1
Mariotti, S1
Shah, R1
Schmidt, ME1
Wiskemann, J1
Johnson, T1
Habermann, N1
Schneeweiss, A1
Steindorf, K1
Peterson, SJ1
Cappola, AR1
Castro, MR1
Dayan, CM1
Farwell, AP1
Hennessey, JV1
Kopp, PA1
Ross, DS1
Samuels, MH1
Sawka, AM1
Taylor, PN1
Jonklaas, J1
Bianco, AC1
Lee, J1
Miller, RS1
Koguchi, M1
Nakahara, Y1
Ebashi, R1
Ogata, A1
Shimokawa, S1
Masuoka, J1
Abe, T1
McNally, LJ1
Ofiaeli, CI1
Oyibo, SO1
Guldvog, I1
Reitsma, LC1
Johnsen, L1
Lauzike, A1
Gibbs, C1
Carlsen, E1
Lende, TH1
Narvestad, JK1
Omdal, R1
Kvaløy, JT1
Hoff, G1
Bernklev, T1
Søiland, H1
Bekkering, GE1
Agoritsas, T1
Lytvyn, L1
Heen, AF1
Abdulazeem, H1
Aertgeerts, B1
Beecher, D1
Brito, JP1
Farhoumand, PD1
Singh Ospina, N1
van Driel, M1
Wallace, E1
Snel, M1
Okwen, PM1
Siemieniuk, R1
Vandvik, PO1
Kuijpers, T1
Vermandere, M1
Tronconi, GM1
Caiulo, S1
Di Frenna, M1
Vigone, MC1
Chiumello, G1
Weber, G1
Jalkanen, A1
Saraste, M1
Gfeller, A1
Surcel, HM1
Airas, L1
Bouras, M1
Hali, F1
Khadir, K1
Addi, H1
Farouki, A1
Benchikhi, H1
Iyasere, CA1
Simmons, LH1
Fintelmann, FJ1
Dighe, AS1
Chaudhari, SS1
Wankhedkar, KP1
Mushiyev, S1
Brondfield, S1
Feingold, KR1
Simonsick, EM1
Chia, CW1
Mammen, JS1
Egan, JM1
Ferrucci, L1
Chen, N1
Wu, Q1
Li, H1
Zhang, T1
Xu, C1
Cunha, FM1
Rodrigues, E1
Oliveira, J1
Saavedra, A1
Vinhas, LS1
Carvalho, D1
Pollock, AJ1
Seibert, T1
Allen, DB1
Massolt, ET1
van der Windt, M1
Korevaar, TI1
Kam, BL1
Burger, JW1
Franssen, GJ1
Lehmphul, I1
Köhrle, J1
Visser, WE1
Peeters, RP1
Carlé, A1
Pedersen, IB1
Knudsen, N1
Perrild, H1
Ovesen, L1
Andersen, S1
Laurberg, P1
An, JH1
Kim, YJ1
Kim, KJ1
Kim, SH1
Kim, NH2
Kim, HY1
Choi, KM1
Baik, SH1
Choi, DS1
Kim, SG1
Benvenga, S1
Sindoni, A1
Hochhausen, C1
Schumann, U1
Fitzgerald, MA1
van Os, E2
Noordam, C2
Hart, W1
Draaisma, JM2
Hart, WP1
Taylor, LJ1
Janssen, OE1
Vigário, Pdos S1
Chachamovitz, DS1
Cordeiro, MF1
Teixeira, Pde F1
de Castro, CL2
de Oliveira, FP1
Vaisman, M2
Eversmann, T1
de Oliveira Chachamovitz, DS1
dos Santos Vigário, P1
Nogueira Cordeiro, MF1
dos Santos Teixeira, Pde F1
van de Ven, AC1
Netea-Maier, RT1
de Vegt, F1
Ross, HA1
Sweep, FC1
Kiemeney, LA1
Hermus, AR1
den Heijer, M1
Bunevicius, A1
Gintauskiene, V1
Podlipskyte, A1
Zaliunas, R1
Brozaitiene, J1
Prange, AJ1
Bunevicius, R1
Scally, MC1
Hodge, A1
Corssmit, EP2
Wiersinga, WM1
FENDLER, K1
ENDROCZI, E1
LISSAK, K1
Alexopoulou, O1
Beguin, C1
De Nayer, P1
Maiter, D1
Kumar, N1
Allen, KA1
Riccardi, D1
Bercu, BB1
Cantor, A1
Minton, S1
Balducci, L1
Jacobsen, PB1
Ozdogan, M1
Yazicioglu, G1
Karadogan, I1
Cevikol, C1
Karayalcin, U1
Undar, L1
Fukata, S1
Brent, GA1
Sugawara, M1
Kisch, E1
Segall, HS1
Klein, J2
Fehm, HL2
Jellinger, PS1
Anolik, JR1
Eustatia-Rutten, CF1
Pereira, AM1
Frölich, M1
Bax, JJ1
Romijn, JA1
Smit, JW1
Pinchera, A1
Santini, F1
Kolyvanos Naumann, U1
Furer, J1
Käser, L1
Vetter, W1
Kilic, M1
Barroso, J1
Pence, BW1
Salahuddin, N1
Harmon, JL1
Leserman, J1
Lipowsky, C1
Schorl-Schweikardt, BA1
Kehl, O1
Brändle, M1
Schimmelmann, BG1
Mehler-Wex, C1
Lambert, M1
Schulze-zur-Wiesch, C1
Koch, E1
Flechtner, HH1
Gierow, B1
Maier, J1
Meyer, E1
Schulte-Markwort, M1
Ghosh, S1
Howlett, M1
Boag, D1
Malik, I1
Collier, A1
Casella, F1
Bossi, I1
Pisano, G1
Montano, N1
Brzezińska, Z1
Kaciuba-Uścilko, H1
Nazar, K1
Valenta, LJ1
Elias, AN1
Mazur, A1
Dzurec, LC1
Kaplan, R1
Palinkas, LA1
Reed, HL1
Reedy, KR1
Do, NV1
Case, HS1
Finney, NS1
Kern, W1
Lindstedt, G1
Eggertsen, R1
Sundbeck, G1
Edén, S1
Nyström, E1
Judd, LL1
Hubbard, B1
Janowsky, DS1
Huey, LY1
Attewell, PA1
Schneeberg, NG1
Dymling, JF1
Becker, DV1
Pfannenstiel, P1
Schulz, A1
Mössner, G1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism[NCT02500342]Phase 4276 participants (Actual)Interventional2014-01-31Completed
The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism - a Substudy of TRUST and IEMO Trials[NCT04354896]Phase 4322 participants (Actual)Interventional2014-05-31Completed
Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism: a Pilot Randomized, Double-blinded, Placebo-controlled Study[NCT04288115]Phase 452 participants (Actual)Interventional2021-03-24Completed
Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial[NCT01660126]Phase 4737 participants (Actual)Interventional2014-05-31Completed
Progressive Resistance Training vs. Relaxation for Breast Cancer Patients During Chemotherapy: A Randomized Controlled Intervention Trial to Evaluate the Biological Mechanisms and Effects of Resistance Training on Fatigue and Quality of Life[NCT01106820]101 participants (Actual)Interventional2010-04-30Completed
Surgical Treatment of Hashimotos Disease. Effect on Antibodies and Clinical Symptoms.[NCT02319538]150 participants (Actual)Interventional2012-02-13Completed
Single-center, Randomized, Double-Blinded, Comparative Study of the Effectiveness of L-carnitine in Patients'Fatigue Degree Changing With Hypothyroidism Who Take Levothyroxine[NCT01769157]Phase 460 participants (Actual)Interventional2012-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Completion Rate

Percentage of randomized participants who completed the trial. (NCT04288115)
Timeframe: 6 months

InterventionParticipants (Count of Participants)
Randomized Participants44

Participants' Willingness to Enter the Trial

Percent of eligible participants approached who consented to participate during the recruitment phase. (NCT04288115)
Timeframe: The time from first consent signed to last consent signed. March 2021 to April 2022.

InterventionParticipants (Count of Participants)
Percentage of Eligible Patients Willing to Participate.52

Recruitment Rate

The number of enrolled (consented) participants divided by the length of the recruitment period. (NCT04288115)
Timeframe: The time from first consent signed to last consent signed. March 2021 to April 2022. 13 months.

Interventionparticipants per month (Number)
Recruitment Rate4

Euro Quality of Life 5-Dimension Self-Report Questionnaire (EQ-5D) Score at Week 6 and Month 6

The EuroQoL [EQ] Group 5-Dimension Self-Report Questionnaire (EQ-5D) scores include the EQ-5D descriptive index, on a scale from -0.59 to 1.00. Higher scores indicate better quality of life. The EQ-5D scores include the score on the EQ visual-analogue scale (EQ-5D VAS), on a scale from 0 to 100. Higher scores indicate better quality of life. (NCT04288115)
Timeframe: 6 weeks and 6 months

,
Interventionscore on a scale (Mean)
EQ-5D Descriptive Score 6 weeksEQ-5D Descriptive Score 6 monthsEQ-5D VAS 6 weeksEQ-5D VAS 6 months
"Levothyroxine Group (Sham Discontinuation)"0.7590.74278.068.4
"Placebo Group (Real Discontinuation)"0.7860.75077.279.9

Lipid Levels

Differences in mean 6-month lipid levels after adjusting for gender and baseline lipid level. (NCT04288115)
Timeframe: 6 months

,
Interventionmg/dL (Mean)
Total cholesterol 6 monthsLDL 6 monthsHDL 6 monthsTriglycerides 6 months
"Levothyroxine Group (Sham Discontinuation)"145.376.542.7137.5
"Placebo Group (Real Discontinuation)"177.4100.251.5139.7

Thyroid-specific Quality of Life Patient-Reported Outcome (ThyPRO) - Hypothyroid Symptoms Score

The Hypothyroid Symptoms score from the Thyroid-Related Quality of Life Patient-Reported Outcome (ThyPRO) questionnaire is assessed on a scale from 0 to 100, with higher scores indicating more symptoms. (NCT04288115)
Timeframe: Baseline, 6 weeks and 6 months

,
Interventionscore on a scale (Mean)
Baseline6 weeks6 months
"Levothyroxine Group (Sham Discontinuation)"21.122.022.9
"Placebo Group (Real Discontinuation)"27.125.328.3

Thyroid-specific Quality of Life Patient-Reported Outcome (ThyPRO) - Tiredness Score

The Tiredness score from the Thyroid-Related Quality of Life Patient-Reported Outcome (ThyPRO) questionnaire is assessed on a scale from 0 to 100, with higher scores indicating more tiredness. (NCT04288115)
Timeframe: Baseline, 6 weeks and 6 months

,
Interventionscore on a scale (Mean)
Baseline6 weeks6 months
"Levothyroxine Group (Sham Discontinuation)"31.133.032.8
"Placebo Group (Real Discontinuation)"33.231.127.6

Reviews

1 review available for thyroxine and Lassitude

ArticleYear
[Subclinical functional disorders of the thyroid gland].
    Nederlands tijdschrift voor geneeskunde, 2003, Jun-14, Volume: 147, Issue:24

    Topics: Depression; Fatigue; Humans; Hyperthyroidism; Hypothyroidism; Risk Factors; Thyroid Diseases; Thyroi

2003

Trials

10 trials available for thyroxine and Lassitude

ArticleYear
A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial.
    International journal of environmental research and public health, 2020, 05-23, Volume: 17, Issue:10

    Topics: Child; Child, Preschool; Diet; Fatigue; Female; Humans; Hypothyroidism; Infant; Life Style; Male; Qu

2020
Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2020, 09-16, Volume: 75, Issue:9

    Topics: Aged; Aged, 80 and over; Asymptomatic Diseases; Fatigue; Female; Humans; Hypothyroidism; Male; Thyro

2020
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
    The New England journal of medicine, 2017, 06-29, Volume: 376, Issue:26

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Fatigue; Female; Humans; Hypothyroidism; Intention to

2017
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
    The New England journal of medicine, 2017, 06-29, Volume: 376, Issue:26

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Fatigue; Female; Humans; Hypothyroidism; Intention to

2017
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
    The New England journal of medicine, 2017, 06-29, Volume: 376, Issue:26

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Fatigue; Female; Humans; Hypothyroidism; Intention to

2017
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
    The New England journal of medicine, 2017, 06-29, Volume: 376, Issue:26

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Fatigue; Female; Humans; Hypothyroidism; Intention to

2017
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
    The New England journal of medicine, 2017, 06-29, Volume: 376, Issue:26

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Fatigue; Female; Humans; Hypothyroidism; Intention to

2017
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
    The New England journal of medicine, 2017, 06-29, Volume: 376, Issue:26

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Fatigue; Female; Humans; Hypothyroidism; Intention to

2017
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
    The New England journal of medicine, 2017, 06-29, Volume: 376, Issue:26

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Fatigue; Female; Humans; Hypothyroidism; Intention to

2017
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
    The New England journal of medicine, 2017, 06-29, Volume: 376, Issue:26

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Fatigue; Female; Humans; Hypothyroidism; Intention to

2017
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
    The New England journal of medicine, 2017, 06-29, Volume: 376, Issue:26

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Fatigue; Female; Humans; Hypothyroidism; Intention to

2017
Thyroidectomy Versus Medical Management for Euthyroid Patients With Hashimoto Disease and Persisting Symptoms: A Randomized Trial.
    Annals of internal medicine, 2019, 04-02, Volume: 170, Issue:7

    Topics: Adolescent; Adult; Aged; Antibodies; Drug Therapy, Combination; Fatigue; Female; Follow-Up Studies;

2019
L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial.
    Endocrine journal, 2016, Oct-29, Volume: 63, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Carnitine; Dietary Supplements; Double-Blind Method; Fatigue; Female

2016
Effects of physical activity on body composition and fatigue perception in patients on thyrotropin-suppressive therapy for differentiated thyroid carcinoma.
    Thyroid : official journal of the American Thyroid Association, 2011, Volume: 21, Issue:7

    Topics: Adult; Body Composition; Cross-Sectional Studies; Fatigue; Female; Humans; Male; Middle Aged; Motor

2011
Quality of life in longterm exogenous subclinical hyperthyroidism and the effects of restoration of euthyroidism, a randomized controlled trial.
    Clinical endocrinology, 2006, Volume: 64, Issue:3

    Topics: Fatigue; Female; Humans; Hyperthyroidism; Male; Middle Aged; Prospective Studies; Psychiatric Status

2006
Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zinc.
    Neuro endocrinology letters, 2007, Volume: 28, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Dietary Supplements; Exercise; Exercise Test; Fatigue; Huma

2007
A prospective 12-week study of quetiapine in adolescents with schizophrenia spectrum disorders.
    Journal of child and adolescent psychopharmacology, 2007, Volume: 17, Issue:6

    Topics: Adolescent; Antipsychotic Agents; Child; Dibenzothiazepines; Dose-Response Relationship, Drug; Fatig

2007
The effect of lithium carbonate on affect, mood, and personality of normal subjects.
    Archives of general psychiatry, 1977, Volume: 34, Issue:3

    Topics: Adult; Affect; Anxiety; Clinical Trials as Topic; Cognition Disorders; Confusion; Emotions; Fatigue;

1977

Other Studies

65 other studies available for thyroxine and Lassitude

ArticleYear
Hormonal trends in patients suffering from long COVID symptoms.
    Endocrine journal, 2022, Oct-28, Volume: 69, Issue:10

    Topics: Aged; Alopecia; COVID-19; Dysgeusia; Fatigue; Female; Humans; Hydrocortisone; Olfaction Disorders; P

2022
Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study.
    Chinese medical journal, 2022, Aug-20, Volume: 135, Issue:16

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Fatigue; Frailty; Humans; Hypothyroidism; Independ

2022
Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study.
    Chinese medical journal, 2022, Aug-20, Volume: 135, Issue:16

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Fatigue; Frailty; Humans; Hypothyroidism; Independ

2022
Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study.
    Chinese medical journal, 2022, Aug-20, Volume: 135, Issue:16

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Fatigue; Frailty; Humans; Hypothyroidism; Independ

2022
Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study.
    Chinese medical journal, 2022, Aug-20, Volume: 135, Issue:16

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Fatigue; Frailty; Humans; Hypothyroidism; Independ

2022
Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study.
    Chinese medical journal, 2022, Aug-20, Volume: 135, Issue:16

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Fatigue; Frailty; Humans; Hypothyroidism; Independ

2022
Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study.
    Chinese medical journal, 2022, Aug-20, Volume: 135, Issue:16

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Fatigue; Frailty; Humans; Hypothyroidism; Independ

2022
Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study.
    Chinese medical journal, 2022, Aug-20, Volume: 135, Issue:16

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Fatigue; Frailty; Humans; Hypothyroidism; Independ

2022
Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study.
    Chinese medical journal, 2022, Aug-20, Volume: 135, Issue:16

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Fatigue; Frailty; Humans; Hypothyroidism; Independ

2022
Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study.
    Chinese medical journal, 2022, Aug-20, Volume: 135, Issue:16

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Fatigue; Frailty; Humans; Hypothyroidism; Independ

2022
FEATURES OF CLINICAL SYMPTOMS AND SIGNS, HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN CHILDREN WITH JOINT HYPERMOBILITY IN A LATE PERIOD UPON THE CHORNOBYL NPP ACCIDENT.
    Problemy radiatsiinoi medytsyny ta radiobiolohii, 2019, Volume: 24

    Topics: Alkaline Phosphatase; Amino Acids; Calcium; Case-Control Studies; Chernobyl Nuclear Accident; Child;

2019
A Case of Bradycardia and Extreme Fatigue.
    The American journal of nursing, 2020, Volume: 120, Issue:5

    Topics: Bradycardia; Electrocardiography; Fatigue; Heart Rate; Humans; Male; Middle Aged; Thyroxine

2020
ENDOCRINE REGULATION OF ERYTHROID LINEAGE OF HEMATOPOIESIS IN CHILDREN LIVING UNDER A LOW-DOSE RADIATION EXPOSURE AFTER THE CHORNOBYL NPP ACCIDENT.
    Problemy radiatsiinoi medytsyny ta radiobiolohii, 2020, Volume: 25

    Topics: Adolescent; Arthralgia; Cell Lineage; Chernobyl Nuclear Accident; Child; Child, Preschool; Dental Ca

2020
Relapsed granulomatosis with polyangiitis with panhypopituitarism.
    BMJ case reports, 2021, Jan-28, Volume: 14, Issue:1

    Topics: Adrenal Insufficiency; Androgens; Diabetes Insipidus; Fatigue; Glucocorticoids; Granulomatosis with

2021
Severe primary hypothyroidism in an apparently asymptomatic 19-year-old woman: a case report.
    Journal of medical case reports, 2021, Mar-03, Volume: 15, Issue:1

    Topics: Alopecia; Appetite; Autoantibodies; Constipation; Depression; Fatigue; Female; Humans; Hypothyroidis

2021
Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link?
    European journal of endocrinology, 2017, Volume: 177, Issue:1

    Topics: Adenocarcinoma; Aged; Autoimmune Diseases; Cohort Studies; Colorectal Neoplasms; Fatigue; Female; Ho

2017
In older adults with subclinical hypothyroidism, levothyroxine did not improve symptoms or tiredness.
    Annals of internal medicine, 2017, 08-15, Volume: 167, Issue:4

    Topics: Adult; Fatigue; Humans; Hypothyroidism; Thyrotropin; Thyroxine

2017
L-Thyroxine intake as a potential risk factor for the development of fatigue in breast cancer patients undergoing chemotherapy.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018, Volume: 26, Issue:8

    Topics: Aged; Breast Neoplasms; Fatigue; Female; Humans; Middle Aged; Risk Factors; Thyroxine

2018
An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.
    Thyroid : official journal of the American Thyroid Association, 2018, Volume: 28, Issue:6

    Topics: Adult; Affect; Aged; Cognition; Depression; Emotions; Fatigue; Female; Health Knowledge, Attitudes,

2018
Case 2: Fatigue and Shortness of Breath in an 18-year-old Girl.
    Pediatrics in review, 2018, Volume: 39, Issue:12

    Topics: Adolescent; Anemia, Iron-Deficiency; Dyspnea; Fatigue; Female; Humans; Hypothyroidism; Thyroid Funct

2018
Status epilepticus induced by treatment with dopamine agonist therapy for giant prolactinoma: a case report.
    Journal of medical case reports, 2019, Jan-20, Volume: 13, Issue:1

    Topics: Adult; Anticonvulsants; Cabergoline; Dopamine Agonists; Fatigue; Frontal Lobe; Humans; Hydrocortison

2019
Treatment-refractory hypothyroidism.
    BMJ (Clinical research ed.), 2019, Feb-25, Volume: 364

    Topics: Disease Management; Fatigue; Humans; Hypothyroidism; Intestinal Absorption; Medication Adherence; Re

2019
Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline.
    BMJ (Clinical research ed.), 2019, May-14, Volume: 365

    Topics: Adult; Aged; Body Mass Index; Decision Making; Decision Support Techniques; Depression; Fatigue; Fem

2019
Rare cases of autoimmune hypothyroidism in young children.
    Journal of pediatric endocrinology & metabolism : JPEM, 2013, Volume: 26, Issue:9-10

    Topics: Appetite; Child, Preschool; Constipation; Delayed Diagnosis; Drug Monitoring; Fatigue; Female; Growt

2013
Increased thyroid autoimmunity among women with multiple sclerosis in the postpartum setting.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2013, Volume: 19, Issue:13

    Topics: Adult; Antibodies; Case-Control Studies; Delivery, Obstetric; Depression, Postpartum; Fatigue; Femal

2013
[Palmoplantar keratoderma: a rare manifestation of myxoedema].
    Annales de dermatologie et de venereologie, 2014, Volume: 141, Issue:1

    Topics: Eczema; Emollients; Facial Dermatoses; Fatigue; Female; Foot Dermatoses; Hand Dermatoses; Hormone Re

2014
Case records of the Massachusetts General Hospital. Case 38-2014. An 87-year-old man with sore throat, hoarseness, fatigue, and dyspnea.
    The New England journal of medicine, 2014, Dec-11, Volume: 371, Issue:24

    Topics: Aged, 80 and over; Aspartate Aminotransferases; Creatine Kinase; Diagnosis, Differential; Dyspnea; F

2014
SLE or hypothyroidism: who can triumph in cardiac tamponade?
    BMJ case reports, 2015, Mar-06, Volume: 2015

    Topics: Adult; Cardiac Tamponade; Dyspnea; Fatigue; Female; Humans; Hypothyroidism; Lupus Erythematosus, Sys

2015
Symptomatic Graves' Disease After Autoimmune Hypothyroidism.
    The American journal of medicine, 2016, Volume: 129, Issue:5

    Topics: Adult; Disease Progression; Fatigue; Graves Disease; Hashimoto Disease; Heart Rate; Humans; Immunogl

2016
Free Thyroxine and Functional Mobility, Fitness, and Fatigue in Euthyroid Older Men and Women in the Baltimore Longitudinal Study of Aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2016, Volume: 71, Issue:7

    Topics: Aged; Aged, 80 and over; Aging; Baltimore; Biomarkers; Disability Evaluation; Energy Metabolism; Fat

2016
Different adaptations of Chinese winter-over expeditioners during prolonged Antarctic and sub-Antarctic residence.
    International journal of biometeorology, 2016, Volume: 60, Issue:5

    Topics: Adaptation, Physiological; Adult; Affect; Anger; Antarctic Regions; Asian People; Depression; Dopami

2016
Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report.
    Journal of medical case reports, 2016, Mar-31, Volume: 10

    Topics: Aged; Antithyroid Agents; Fatigue; Female; Goiter; Graves Disease; Humans; Mediastinal Diseases; Met

2016
Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth.
    The Journal of pediatrics, 2016, Volume: 173

    Topics: Acne Vulgaris; Adolescent; Anti-Bacterial Agents; Diplopia; Fatigue; Female; Headache; Humans; Hyper

2016
Thyroid hormone and its metabolites in relation to quality of life in patients treated for differentiated thyroid cancer.
    Clinical endocrinology, 2016, Volume: 85, Issue:5

    Topics: Fatigue; Female; Humans; Male; Middle Aged; Quality of Life; Thyroid Function Tests; Thyroid Hormone

2016
Hypothyroid Symptoms Fail to Predict Thyroid Insufficiency in Old People: A Population-Based Case-Control Study.
    The American journal of medicine, 2016, Volume: 129, Issue:10

    Topics: Adult; Aged; Autoantibodies; Case-Control Studies; Dyspnea; Fatigue; Female; Hashimoto Disease; Huma

2016
L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment [Letter to the Editor].
    Endocrine journal, 2016, 10-29, Volume: 63, Issue:10

    Topics: Carnitine; Dietary Supplements; Fatigue; Humans; Hypothyroidism; Thyroxine

2016
[A 78-year-old woman suffering from diarrhea, abnormal fatigue, and depression].
    Der Internist, 2009, Volume: 50, Issue:1

    Topics: Aged; Anti-Inflammatory Agents; Depression; Diagnosis, Differential; Diarrhea; Fatigue; Female; Huma

2009
Fight fatigue by evaluating thyroid function.
    The Nurse practitioner, 2008, Volume: 33, Issue:12

    Topics: Adult; Aged; Fatigue; Female; Humans; Hypothyroidism; Male; Middle Aged; Thyrotropin; Thyroxine; Tre

2008
[Clinical reasoning and decision making in clinical practice: a boy with fatigue and abdominal pain].
    Nederlands tijdschrift voor geneeskunde, 2009, May-23, Volume: 153, Issue:21

    Topics: Abdominal Pain; Adolescent; Adrenal Insufficiency; Anemia; Creatine Kinase; Diagnosis, Differential;

2009
[Clinical reasoning and decision making in clinical practice: a boy with fatigue and abdominal pain].
    Nederlands tijdschrift voor geneeskunde, 2009, Volume: 153

    Topics: Abdominal Pain; Adolescent; Adrenal Insufficiency; Anemia; Creatine Kinase; Diagnosis, Differential;

2009
Think thyroid. Connecting an assortment of symptoms leads to a hypothyroidism diagnosis.
    Advance for NPs & PAs, 2010, Volume: 1, Issue:3

    Topics: Adult; Anorexia; Dizziness; Fatigue; Female; Humans; Hypothyroidism; Muscle Weakness; Physical Exami

2010
[47-year-old man with fatigue and hair loss].
    Deutsche medizinische Wochenschrift (1946), 2011, Volume: 136, Issue:11

    Topics: Alopecia Areata; Fatigue; Hashimoto Disease; Hormones; Humans; Hypothyroidism; Male; Middle Aged; Th

2011
[Hypothyroidism].
    MMW Fortschritte der Medizin, 2011, Mar-03, Volume: 153, Issue:9

    Topics: Aged; Algorithms; Fatigue; Female; Humans; Hypothyroidism; Iodine; Pregnancy; Selenium; Thyroid Func

2011
Quality of life, muscle strength, and fatigue perception in patients on suppressive therapy with levothyroxine for differentiated thyroid carcinoma.
    American journal of clinical oncology, 2013, Volume: 36, Issue:4

    Topics: Adult; Aged; Cross-Sectional Studies; Fatigue; Female; Follow-Up Studies; Hand Strength; Humans; Hyp

2013
Is there a relationship between fatigue perception and the serum levels of thyrotropin and free thyroxine in euthyroid subjects?
    Thyroid : official journal of the American Thyroid Association, 2012, Volume: 22, Issue:12

    Topics: Adult; Aged; Autoantibodies; Fatigue; Female; Humans; Iodide Peroxidase; Male; Middle Aged; Percepti

2012
Fatigue in patients with coronary artery disease: association with thyroid axis hormones and cortisol.
    Psychosomatic medicine, 2012, Volume: 74, Issue:8

    Topics: Adrenal Glands; Coronary Artery Disease; Cross-Sectional Studies; Exercise Test; Exercise Tolerance;

2012
A report of hypothyroidism induced by an over-the-counter fat loss supplement (Tiratricol).
    International journal of sport nutrition and exercise metabolism, 2003, Volume: 13, Issue:1

    Topics: Adult; Anti-Obesity Agents; Diet, Fat-Restricted; Dietary Supplements; Fatigue; Female; Humans; Hypo

2003
CHANGES IN THE OXYTOCIN CONTENT OF THE POSTERIOR PITUITARY IN THE RAT, FOLLOWING OVARIECTOMY, THYROIDECTOMY, OXYTOCIN AND THYROXINE TREATMENT.
    Acta physiologica Academiae Scientiarum Hungaricae, 1964, Volume: 25

    Topics: Adaptation, Physiological; Castration; Cold Temperature; Fatigue; Female; Humans; Male; Orchiectomy;

1964
Clinical and hormonal characteristics of central hypothyroidism at diagnosis and during follow-up in adult patients.
    European journal of endocrinology, 2004, Volume: 150, Issue:1

    Topics: Adult; Age of Onset; Aged; Fatigue; Female; Follow-Up Studies; Growth Disorders; Headache; Human Gro

2004
Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit?
    Breast cancer research and treatment, 2004, Volume: 83, Issue:2

    Topics: Adult; Aged; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophos

2004
Sheehan's syndrome associated with pancytopenia due to marrow aplasia; full recovery with hormone replacement therapy.
    International journal of clinical practice, 2004, Volume: 58, Issue:5

    Topics: Adrenal Cortex Hormones; Anemia, Aplastic; Dyspnea; Fatigue; Female; Hormone Replacement Therapy; Hu

2004
Resistance to thyroid hormone in Hashimoto's thyroiditis.
    The New England journal of medicine, 2005, Feb-03, Volume: 352, Issue:5

    Topics: Adult; Biomarkers; Drug Resistance; Fatigue; Female; Humans; Point Mutation; Receptors, Thyroid Horm

2005
Interaction between simvastatin and L-thyroxine.
    Annals of internal medicine, 2005, Oct-04, Volume: 143, Issue:7

    Topics: Abdominal Pain; Aged; Aged, 80 and over; Anticholesteremic Agents; Drug Interactions; Fatigue; Femal

2005
Unusual presentation of hypophysitis preceding an empty sella in a 75-year-old woman.
    Neuro endocrinology letters, 2005, Volume: 26, Issue:6

    Topics: Aged; Atrophy; Diagnosis, Differential; Empty Sella Syndrome; Fatigue; Female; Hormones; Humans; Hyd

2005
Acquired hypothyroidism after switching from thyroid USP to levothyroxine.
    Clinical cornerstone, 2005, Volume: 7 Suppl 2

    Topics: Depression; Drug Therapy, Combination; Fatigue; Female; Hormone Replacement Therapy; Humans; Hypothy

2005
Hypothyroid symptoms following radioiodine therapy for Graves' disease.
    Clinical cornerstone, 2005, Volume: 7 Suppl 2

    Topics: Antithyroid Agents; Drug Therapy, Combination; Fatigue; Graves Disease; Humans; Hypothyroidism; Iodi

2005
Is combined therapy with levothyroxine and liothyronine effective in patients with primary hypothyroidism?
    Nature clinical practice. Endocrinology & metabolism, 2005, Volume: 1, Issue:1

    Topics: Affect; Double-Blind Method; Drug Therapy, Combination; Fatigue; Humans; Hypothyroidism; Prospective

2005
[Hypothyroidism. Main symptoms: fatigue, weight gain, depression, myalgia, edema].
    Praxis, 2007, Sep-19, Volume: 96, Issue:38

    Topics: Adult; Depression; Diagnosis, Differential; Edema; Fatigue; Female; Humans; Hypothyroidism; Muscular

2007
Physiological correlates of HIV-related fatigue.
    Clinical nursing research, 2008, Volume: 17, Issue:1

    Topics: Adult; Aged; Attitude to Health; Bilirubin; Case-Control Studies; Fatigue; Female; Hematocrit; HIV S

2008
[19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)].
    Praxis, 2008, Jan-23, Volume: 97, Issue:2

    Topics: Addison Disease; Adrenocorticotropic Hormone; Adult; Cortisone; Diagnosis, Differential; Drug Therap

2008
Interference in free thyroxine immunoassay.
    European journal of internal medicine, 2008, Volume: 19, Issue:3

    Topics: Aged; Aged, 80 and over; Antibodies, Heterophile; Diagnosis, Differential; False Positive Reactions;

2008
An atypical case of typical chest pain.
    Internal and emergency medicine, 2008, Volume: 3, Issue:4

    Topics: Administration, Cutaneous; Administration, Sublingual; Aged; Angina Pectoris; Chest Pain; Diagnosis,

2008
Physiological responses to prolonged physical exercise in dogs.
    Archives internationales de physiologie et de biochimie, 1980, Volume: 88, Issue:3

    Topics: 17-Hydroxycorticosteroids; Animals; Blood Glucose; Body Temperature; Dogs; Epinephrine; Fatigue; Fat

1980
How to detect hypothyroidism when screening tests are normal. Use of the TRH stimulation test.
    Postgraduate medicine, 1983, Volume: 74, Issue:2

    Topics: Adult; Body Weight; Cholesterol; Fatigue; Female; Goiter; Humans; Hypothyroidism; Male; Middle Aged;

1983
Do cortisol and thyroxin correlate with nervousness and depression among male army veterans?
    Biological psychology, 1994, Volume: 37, Issue:3

    Topics: Adult; Anxiety; Arousal; Depression; Fatigue; Humans; Hydrocortisone; Male; Middle Aged; Sleep Initi

1994
Experiences of fatigue and depression before and after low-dose 1-thyroxine supplementation in essentially euthyroid individuals.
    Research in nursing & health, 1997, Volume: 20, Issue:5

    Topics: Adult; Confusion; Depression; Fatigue; Female; Humans; Hypothyroidism; Male; Middle Aged; Nursing Me

1997
Thyroxine abuse.
    The Australian and New Zealand journal of psychiatry, 1998, Volume: 32, Issue:3

    Topics: Adult; Anorexia Nervosa; Arousal; Fatigue; Humans; Male; Substance-Related Disorders; Thyroxine; Wei

1998
Circannual pattern of hypothalamic-pituitary-thyroid (HPT) function and mood during extended antarctic residence.
    Psychoneuroendocrinology, 2001, Volume: 26, Issue:4

    Topics: Adult; Affect; Anger; Antarctic Regions; Confusion; Depression; Fatigue; Female; Humans; Hypothalamu

2001
Fatigue and hyponatremia in a 75-year-old woman: unusual presentation of hypophysitis.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2001, Volume: 109, Issue:2

    Topics: Adrenal Insufficiency; Aged; Drug Therapy, Combination; Fatigue; Female; Humans; Hydrocortisone; Hyp

2001
Thyroid dysfunction and chronic fatigue.
    Lancet (London, England), 2001, Jul-14, Volume: 358, Issue:9276

    Topics: Adult; Antibodies; Chronic Disease; Fatigue; Humans; Hypothyroidism; Iodide Peroxidase; Mass Screeni

2001
Pseudohypothyroidism. Differentiation from true hypothyroidism.
    Postgraduate medicine, 1986, May-15, Volume: 79, Issue:7

    Topics: Diagnostic Errors; Fatigue; Female; Humans; Hypothyroidism; Thyroid Hormones; Thyrotropin; Thyroxine

1986
Occurrence of hyperthyroidism in patients receiving thyroid hormone.
    The Journal of clinical endocrinology and metabolism, 1967, Volume: 27, Issue:10

    Topics: Adolescent; Adult; Alopecia; Antithyroid Agents; Fatigue; Female; Goiter; Graves Disease; Humans; Hy

1967
[Eyelid edemas, cryesthesia and decrease in vitality during long term lithium therapy].
    Deutsche medizinische Wochenschrift (1946), 1973, Aug-24, Volume: 98, Issue:34

    Topics: Ataxia; Body Temperature Regulation; Cold Temperature; Edema; Eyelid Diseases; Fatigue; Female; Huma

1973