thyroxine has been researched along with Keratoconus in 6 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Keratoconus: A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Urea and prolactin concentrations are decreased, fT4 concentration is increased in aqueous humor of keratoconus patients, and uric acid concentration remains unchanged." | 7.85 | Urea, Uric Acid, Prolactin and fT4 Concentrations in Aqueous Humor of Keratoconus Patients. ( Hartmann, U; Langenbucher, A; Seitz, B; Stachon, A; Stachon, T; Szentmáry, N, 2017) |
| "Keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population." | 5.35 | Acute keratoconus induced by hypothyroxinemia during pregnancy. ( Gatzioufas, Z; Thanos, S, 2008) |
| "Urea and prolactin concentrations are decreased, fT4 concentration is increased in aqueous humor of keratoconus patients, and uric acid concentration remains unchanged." | 3.85 | Urea, Uric Acid, Prolactin and fT4 Concentrations in Aqueous Humor of Keratoconus Patients. ( Hartmann, U; Langenbucher, A; Seitz, B; Stachon, A; Stachon, T; Szentmáry, N, 2017) |
| "Keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population." | 1.35 | Acute keratoconus induced by hypothyroxinemia during pregnancy. ( Gatzioufas, Z; Thanos, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, JJ | 1 |
| Gatzioufas, Z | 3 |
| Panos, GD | 1 |
| Brugnolli, E | 1 |
| Hafezi, F | 1 |
| Thanos, S | 2 |
| Oellers, P | 1 |
| Meyer Zu Hörste, M | 1 |
| Prokosch, V | 1 |
| Schlatt, S | 1 |
| Seitz, B | 2 |
| Stachon, T | 1 |
| Stachon, A | 1 |
| Hartmann, U | 1 |
| Langenbucher, A | 1 |
| Szentmáry, N | 1 |
| Kahán, IL | 1 |
| Varsányi-Nagy, M | 1 |
| Tóth, M | 1 |
| Nádrai, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Corneal Tomographic Analysis Among Patients With Thyroid Gland Dysfunction.[NCT04433936] | 100 participants (Actual) | Observational | 2018-02-01 | Completed | |||
| Influence of Pregnancy-related Hormonal Fluctuations on Corneal Biomechanics in Humans[NCT01629264] | 50 participants (Actual) | Observational | 2012-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for thyroxine and Keratoconus
| Article | Year |
|---|---|
Thyroid Gland Dysfunction and Keratoconus.
Topics: Humans; Keratoconus; Thyroid Diseases; Thyroxine | 2018 |
Corneal topographical and biomechanical variations associated with hypothyroidism.
Topics: Cornea; Corneal Pachymetry; Corneal Topography; Dilatation, Pathologic; Female; Humans; Hypothyroidi | 2014 |
Role of Thyroxine in the Development of Keratoconus.
Topics: Adult; Aged; Animals; Cell Culture Techniques; Corneal Keratocytes; Enzyme-Linked Immunosorbent Assa | 2016 |
Urea, Uric Acid, Prolactin and fT4 Concentrations in Aqueous Humor of Keratoconus Patients.
Topics: Adult; Aged; Aqueous Humor; Biomarkers; Female; Humans; Immunoassay; Keratoconus; Male; Middle Aged; | 2017 |
Acute keratoconus induced by hypothyroxinemia during pregnancy.
Topics: Adult; Autoantibodies; Female; Hashimoto Disease; Humans; Hypothyroidism; Iodide Peroxidase; Keratoc | 2008 |
Acute keratoconus induced by hypothyroxinemia during pregnancy.
Topics: Adult; Autoantibodies; Female; Hashimoto Disease; Humans; Hypothyroidism; Iodide Peroxidase; Keratoc | 2008 |
Acute keratoconus induced by hypothyroxinemia during pregnancy.
Topics: Adult; Autoantibodies; Female; Hashimoto Disease; Humans; Hypothyroidism; Iodide Peroxidase; Keratoc | 2008 |
Acute keratoconus induced by hypothyroxinemia during pregnancy.
Topics: Adult; Autoantibodies; Female; Hashimoto Disease; Humans; Hypothyroidism; Iodide Peroxidase; Keratoc | 2008 |
The possible role of tear fluid thyroxine in keratoconus development.
Topics: Adolescent; Adult; Female; Humans; Hyperthyroidism; Hypothyroidism; Keratoconus; Male; Tears; Thyrox | 1990 |