Page last updated: 2024-11-06

thyroxine and Infant, Small for Gestational Age

thyroxine has been researched along with Infant, Small for Gestational Age in 36 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Infant, Small for Gestational Age: An infant having a birth weight lower than expected for its gestational age.

Research Excerpts

ExcerptRelevanceReference
"The fetus is most vulnerable to severe iodine deficiency and hypothyroidism during pregnancy."7.75Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring. ( Alvarez-Pedrerol, M; Canet, Y; Espada, M; Guxens, M; Martorell, R; Mendez, M; Plana, E; Rebagliato, M; Sunyer, J, 2009)
" It is unknown, however, whether the relationships between maternal thyrotropin (TSH) and free thyroxine (fT4) levels in early pregnancy and fetal growth outcomes are modified by fetal sex."3.85Early Maternal Thyroid Function During Gestation Is Associated With Fetal Growth, Particularly in Male Newborns. ( Hrudey, EJ; Twickler, MB; Vrijkotte, TG, 2017)
"The fetus is most vulnerable to severe iodine deficiency and hypothyroidism during pregnancy."3.75Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring. ( Alvarez-Pedrerol, M; Canet, Y; Espada, M; Guxens, M; Martorell, R; Mendez, M; Plana, E; Rebagliato, M; Sunyer, J, 2009)
" The urinary epidermal growth factor/creatinine ratio (EGF/Cr) on the 1st postnatal day was not statistically different among full-term, premature, multiple-pregnancy, and small-for-gestational-age infants (F = 1."3.70Correlation between urinary epidermal growth factor excretion and serum thyroid hormone in premature and term neonates. ( Chen, CH; Teng, RJ; Tsau, YK, 1998)
" Basal concentrations of serum thyroxine (T4), free thyroxine (free T4) and triiodothyronine (T3) were positively correlated to gestational age and birth weight (p less than 0."3.68Maturation of the pituitary-thyroid axis during the perinatal period. ( Hashimoto, H; Horita, S; Kubo, M; Ohki, T; Sato, T, 1991)
"Hyperthyroidism was associated with an increased risk of preterm birth (PTB, adjusted OR: 2."1.62Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China. ( Gao, Y; Wang, H; Wang, J; Yu, B; Yuan, X, 2021)
"There was a 73% less chance of gestational hypertension for thyroid autoimmune groups."1.62Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4). ( Islam, N; Kiran, Z; Sheikh, A, 2021)
" The outcome measures included the incidence of adverse events (AEs, in particular, neoplasia, glucose intolerance and hypothyroidism), as well as height standard deviation score (Ht SDS) and annual height velocity."1.51Long-term safety and effectiveness of growth hormone therapy in Korean children with growth disorders: 5-year results of LG Growth Study. ( Chae, HW; Choi, JH; Chung, S; Hwang, IT; Kim, EY; Kim, HS; Kim, JH; Rhie, YJ; Shin, CH; Yoo, JH, 2019)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199012 (33.33)18.7374
1990's3 (8.33)18.2507
2000's8 (22.22)29.6817
2010's9 (25.00)24.3611
2020's4 (11.11)2.80

Authors

AuthorsStudies
Grob, F1
Gutiérrez, M1
Leguizamón, L1
Fabres, J1
Liu, C1
Wang, K1
Guo, J1
Chen, J1
Chen, M1
Xie, Z1
Chen, P1
Wu, B1
Lin, N1
Yuan, X1
Wang, J1
Gao, Y1
Wang, H1
Yu, B1
Kiran, Z1
Sheikh, A1
Islam, N1
Vrijkotte, TG1
Hrudey, EJ1
Twickler, MB1
Zhu, YD1
Han, Y1
Huang, K1
Zhu, BB1
Yan, SQ1
Ge, X1
Zhou, SS1
Xu, YY1
Ren, LI1
Sheng, J1
Pan, WJ1
Hao, JH1
Zhu, P1
Tao, FB1
Rhie, YJ1
Yoo, JH1
Choi, JH1
Chae, HW1
Kim, JH1
Chung, S1
Hwang, IT1
Shin, CH1
Kim, EY1
Kim, HS1
Hollanders, JJ1
Israëls, J1
van der Pal, SM1
Verkerk, PH1
Rotteveel, J2
Finken, MJ2
Alvarez-Pedrerol, M1
Guxens, M1
Mendez, M1
Canet, Y1
Martorell, R1
Espada, M1
Plana, E1
Rebagliato, M1
Sunyer, J1
Iñiguez, G1
Ormazabal, P1
López, T1
Maldonado, D1
Avila, A1
Román, R1
Cassorla, F1
Arai, H1
Goto, R1
Matsuda, T1
Takahashi, T1
Buscicchio, G1
Gentilucci, L1
Baldini, E1
Giannubilo, SR1
Tranquilli, AL1
Leitner, AY1
Pellegrini, F1
Beck-Peccoz, P1
Wanker, P1
Persani, L1
Radetti, G1
Karagiannis, G1
Ashoor, G1
Maiz, N1
Jawdat, F1
Nicolaides, KH1
Hokken-Koelega, AC2
Mollee, TS1
van Weissenbruch, MM1
Lem, AJ1
de Rijke, YB1
van Toor, H1
de Ridder, MA1
Visser, TJ1
Cianfarani, S1
Martinez, C1
Maiorana, A1
Scirè, G1
Spadoni, GL1
Boemi, S1
Mahajan, SD1
Aalinkeel, R1
Singh, S1
Shah, P1
Gupta, N1
Kochupillai, N1
Cartault Grandmottet, A1
Cristini, C1
Tricoire, J1
Rolland, M1
Tauber, MT1
Salles, JP1
Jacobsen, BB4
Etling, N1
Padovani, E1
Gehin-Fouque, F1
Tato, L1
Zumsteg, U1
Girard, J1
Kok, JH1
Hart, G1
Endert, E1
Koppe, JG1
de Vijlder, JJ1
Uhrmann, S2
Marks, KH2
Maisels, MJ2
Kulin, HE2
Kaplan, M2
Utiger, R2
Tsau, YK1
Teng, RJ1
Chen, CH1
de L Costello, AM1
Pal, DK1
Manandhar, DS1
Rajbhandari, S1
Land, JM1
Patel, N1
Hummer, L3
Andersen, H1
Dige-Petersen, H2
Erenberg, A1
Friedman, Z1
Murray, F1
Andersen, HJ1
Peitersen, AB1
Hashimoto, H1
Sato, T1
Horita, S1
Kubo, M1
Ohki, T1
Yunoki, H1
Yagi, H1
Nagashima, K1
Noji, T1
Miyake, H1
Kuroume, T1
Lao, TT1
Chin, RK1
Swaminathan, R1
Mishra, JN1
Rai, MG1
Chakravorty, S1
Prasad, S1
Chourdia, ML1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Iodine Nutrition During Pregnancy and Related Neonatal Physical Development[NCT02586220]250 participants (Actual)Observational2015-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for thyroxine and Infant, Small for Gestational Age

ArticleYear
Thyroid function in infancy.
    Danish medical bulletin, 1983, Volume: 30, Issue:5

    Topics: Female; Fetal Blood; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age;

1983

Other Studies

35 other studies available for thyroxine and Infant, Small for Gestational Age

ArticleYear
Hyperthyrotropinemia is common in preterm infants who are born small for gestational age.
    Journal of pediatric endocrinology & metabolism : JPEM, 2020, Mar-26, Volume: 33, Issue:3

    Topics: Cohort Studies; Congenital Hypothyroidism; Female; Gestational Age; Humans; Hyperthyroidism; Inciden

2020
Small for gestational age is a risk factor for thyroid dysfunction in preterm newborns.
    BMC pediatrics, 2020, 04-23, Volume: 20, Issue:1

    Topics: China; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Small for Gestat

2020
Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China.
    Endocrine journal, 2021, Mar-28, Volume: 68, Issue:3

    Topics: Adult; China; Cohort Studies; Female; Fetal Macrosomia; Humans; Hyperthyroidism; Hyperthyroxinemia;

2021
Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4).
    BMC pregnancy and childbirth, 2021, Feb-15, Volume: 21, Issue:1

    Topics: Abortion, Spontaneous; Abruptio Placentae; Adult; Apgar Score; Autoantibodies; Autoimmune Diseases;

2021
Early Maternal Thyroid Function During Gestation Is Associated With Fetal Growth, Particularly in Male Newborns.
    The Journal of clinical endocrinology and metabolism, 2017, 03-01, Volume: 102, Issue:3

    Topics: Adult; Asymptomatic Diseases; Autoantibodies; Birth Weight; Cohort Studies; Female; Fetal Macrosomia

2017
The impact of isolated maternal hypothyroxinaemia on the incidence of large-for-gestational-age infants: the Ma'anshan Birth Cohort study.
    BJOG : an international journal of obstetrics and gynaecology, 2018, Volume: 125, Issue:9

    Topics: Adolescent; Adult; Birth Weight; China; Female; Gestational Age; Humans; Hypothyroidism; Incidence;

2018
Long-term safety and effectiveness of growth hormone therapy in Korean children with growth disorders: 5-year results of LG Growth Study.
    PloS one, 2019, Volume: 14, Issue:5

    Topics: Adolescent; Blood Glucose; Body Height; Child; Child, Preschool; Female; Follow-Up Studies; Glycated

2019
No Association Between Transient Hypothyroxinemia of Prematurity and Neurodevelopmental Outcome in Young Adulthood.
    The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:12

    Topics: Cohort Studies; Congenital Hypothyroidism; Developmental Disabilities; Female; Follow-Up Studies; Hu

2015
Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring.
    European journal of endocrinology, 2009, Volume: 160, Issue:3

    Topics: Adult; Birth Weight; Female; Humans; Hypothyroidism; Infant, Newborn; Infant, Small for Gestational

2009
IGF-IR/ERK content and response to IGF-I and insulin in adipocytes from small for gestational age children.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2009, Volume: 19, Issue:3

    Topics: Adipocytes; Blotting, Western; Child; Female; Gestational Age; Humans; Hypoglycemic Agents; Infant,

2009
Relationship between free T4 levels and postnatal steroid therapy in preterm infants.
    Pediatrics international : official journal of the Japan Pediatric Society, 2009, Volume: 51, Issue:6

    Topics: Anti-Inflammatory Agents; Dexamethasone; Female; Gestational Age; Humans; Hypothyroidism; Infant, Ne

2009
Computerized analysis of heart rate in fetuses from mothers under levothyroxin treatment.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2009, Volume: 25, Issue:10

    Topics: Adult; Cardiotocography; Female; Fetal Monitoring; Fetus; Heart Rate, Fetal; Humans; Hypothyroidism;

2009
The natural history of the hyperthyrotropinemia of children born prematurely.
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:3

    Topics: Adolescent; Autoantibodies; Autoantigens; Blood Glucose; Child; Child, Preschool; Congenital Hypothy

2012
Maternal thyroid function at eleven to thirteen weeks of gestation and subsequent delivery of small for gestational age neonates.
    Thyroid : official journal of the American Thyroid Association, 2011, Volume: 21, Issue:10

    Topics: Adult; Female; Humans; Hypothyroidism; Infant, Newborn; Infant, Small for Gestational Age; Pregnancy

2011
Diagnostic workup of the short child.
    Hormone research in paediatrics, 2011, Volume: 76 Suppl 3

    Topics: Blood Chemical Analysis; Body Height; Child; Child, Preschool; Dwarfism, Pituitary; Female; Growth D

2011
Normal thyroid function in young adults who were born very preterm.
    Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:11-12

    Topics: Birth Weight; Body Composition; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, Prematur

2011
Serum thyroid hormone levels in healthy children from birth to adulthood and in short children born small for gestational age.
    The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:9

    Topics: Adolescent; Aging; Body Height; Child; Child, Preschool; Female; Human Growth Hormone; Humans; Infan

2012
Adiponectin levels are reduced in children born small for gestational age and are inversely related to postnatal catch-up growth.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:3

    Topics: Adiponectin; Child; Child, Preschool; Female; Humans; Infant, Newborn; Infant, Small for Gestational

2004
Thyroid hormone dysregulation in intrauterine growth retardation associated with maternal malnutrition and/or anemia.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2005, Volume: 37, Issue:10

    Topics: Anemia; Female; Fetal Blood; Fetal Growth Retardation; Fetal Nutrition Disorders; Humans; Infant, Ne

2005
[TSH, FT4 and T3T evaluation in normal and preterm hospitalized newborns].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2007, Volume: 14, Issue:2

    Topics: Gestational Age; Hospitalization; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gest

2007
Serum and urine thyroid hormone levels in healthy preterm and small for date infants on the first and fifth day of life.
    Helvetica paediatrica acta, 1984, Volume: 39, Issue:3

    Topics: Adult; Age Factors; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestationa

1984
Direct assay of free thyroxine in the newborn.
    Helvetica paediatrica acta, 1984, Volume: 39, Issue:1

    Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Infant, Small for Gestational

1984
Normal ranges of T4 screening values in low birthweight infants.
    Archives of disease in childhood, 1983, Volume: 58, Issue:3

    Topics: Birth Weight; Fetal Blood; Gestational Age; Humans; Infant, Low Birth Weight; Infant, Newborn; Infan

1983
Frequency of transient hypothyroxinaemia in low birthweight infants. Potential pitfall for neonatal screening programmes.
    Archives of disease in childhood, 1981, Volume: 56, Issue:3

    Topics: Aging; Humans; Hyaline Membrane Disease; Infant, Low Birth Weight; Infant, Newborn; Infant, Small fo

1981
Correlation between urinary epidermal growth factor excretion and serum thyroid hormone in premature and term neonates.
    Nephron, 1998, Volume: 78, Issue:2

    Topics: Creatinine; Epidermal Growth Factor; Female; Gestational Age; Humans; Infant, Newborn; Infant, Prema

1998
Neonatal hypoglycaemia in Nepal 2. Availability of alternative fuels.
    Archives of disease in childhood. Fetal and neonatal edition, 2000, Volume: 82, Issue:1

    Topics: Age Factors; Blood Glucose; Cross-Sectional Studies; Energy Metabolism; Fatty Acids, Nonesterified;

2000
Changes in serum concentrations of thyroid hormones and thyroid hormone-binding proteins during early infancy. Studies in healthy fullterm, small-for-gestational age and preterm infants aged 7 to 240 days.
    Acta paediatrica Scandinavica, 1979, Volume: 68, Issue:3

    Topics: Age Factors; Birth Weight; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Small for Ges

1979
Pituitary-thyroid responsiveness to thyrotropin-releasing hormone in preterm and small-for-gestational age newborns.
    Acta paediatrica Scandinavica, 1977, Volume: 66, Issue:5

    Topics: Female; Gestational Age; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infan

1977
The effect of perinatal factors on cord thyroxine concentration.
    Early human development, 1978, Volume: 2, Issue:3

    Topics: Birth Weight; Congenital Hypothyroidism; False Negative Reactions; False Positive Reactions; Female;

1978
Thyroid function in the preterm infant: a longitudinal assessment.
    The Journal of pediatrics, 1978, Volume: 92, Issue:6

    Topics: Charcoal; Fetal Blood; Humans; Hyaline Membrane Disease; Infant, Newborn; Infant, Premature; Infant,

1978
Serum levels of thyrotropin, thyroxine and triiodothyronine in fullterm, small-for-gestational age and preterm newborn babies.
    Acta paediatrica Scandinavica, 1977, Volume: 66, Issue:6

    Topics: Female; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Male; Thyrotr

1977
Maturation of the pituitary-thyroid axis during the perinatal period.
    Endocrinologia japonica, 1991, Volume: 38, Issue:2

    Topics: Birth Weight; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestati

1991
N-terminal propeptide of type-III procollagen concentrations in the cord blood: an index of newborn maturity.
    Biology of the neonate, 1990, Volume: 58, Issue:5

    Topics: Biomarkers; Chromatography, Gel; Fetal Blood; Humans; Infant, Newborn; Infant, Premature; Infant, Sm

1990
Thyroid function in pre-eclampsia.
    British journal of obstetrics and gynaecology, 1988, Volume: 95, Issue:9

    Topics: Adult; Female; Humans; Infant, Newborn; Infant, Small for Gestational Age; Pre-Eclampsia; Pregnancy;

1988
Thyroid function in newborns.
    Indian pediatrics, 1986, Volume: 23, Issue:7

    Topics: Humans; Infant, Newborn; Infant, Small for Gestational Age; Thyroid Function Tests; Thyrotropin; Thy

1986