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thyroxine and Inborn Errors of Metabolism

thyroxine has been researched along with Inborn Errors of Metabolism in 36 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"Familial dysalbuminemic hyperthyroxinemia (FDH) is a familial autosomal dominant syndrome caused by abnormal albumin with an increased affinity for thyroxine (T4)."7.72Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. ( Hoshikawa, S; Ito, S; Kaise, N; Mori, K; Nakagawa, Y; Yoshida, K, 2004)
"Familial dysalbuminemic hyperthyroxinemia (FDH) is a familial autosomal dominant syndrome caused by abnormal albumin with an increased affinity for thyroxine (T4)."3.72Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. ( Hoshikawa, S; Ito, S; Kaise, N; Mori, K; Nakagawa, Y; Yoshida, K, 2004)
"Congenital hypothyroidism is a common preventable cause of mental retardation."2.40Congenital hypothyroidism: etiologies, diagnosis, and management. ( LaFranchi, S, 1999)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199032 (88.89)18.7374
1990's2 (5.56)18.2507
2000's1 (2.78)29.6817
2010's1 (2.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pieroni, KP1
Bass, D1
WIENER, JD1
LINDEBOOM, GA1
MURRAY, P1
THOMSON, JA2
MCGIRR, EM1
WALLACE, TJ2
MACDONALD, EM1
MACCABE, HJ1
BECROFT, DM1
PHILLIPS, LI1
EL-TORAEI, I1
GABR, MK1
EL-SAADANI, AK1
SALLAM, F1
SAFOUH, M1
Hoshikawa, S1
Mori, K1
Kaise, N1
Nakagawa, Y1
Ito, S1
Yoshida, K1
Docter, R2
Bos, G2
Krenning, EP2
Fekkes, D1
Visser, TJ2
Hennemann, G2
Burger, AG1
Engler, D1
Buergi, U1
Weissel, M1
Steiger, G1
Ingbar, SH1
Rosin, RE1
Babior, BM1
Hershkovitz, E1
Leiberman, E1
Refetoff, S2
Pilpell, D1
Phillip, M1
LaFranchi, S1
Otten, M1
van Jaarsveld, PP1
Albrecht, CF1
Theron, CN1
van Zyl, A1
Konno, N1
Gershengorn, MC1
Weintraub, BD1
Couch, RM1
Dean, HJ1
Winter, JS1
Hayek, A1
Stanbury, JB1
Fisher, DA1
Strunge, P1
Harden, RM1
Alexander, WD1
Papadopoulos, S1
Harrison, MT1
Macfarlane, S1
Bigozzi, U1
Bigazzi, M1
Guazzelli, R1
Melani, F1
Papadopoulos, SN1
Vagenakis, AG1
Moschos, A1
Koutras, DA2
Matsaniotis, N1
Malamos, B2
Bismuth, J1
Bechet, MM1
Lissitzky, S1
Lindeskog, GR1
Gustafson, A1
Enerbäck, L1
Panizon, F1
Voss, C1
Hartmann, N1
Klebanoff, SJ2
Green, WL1
Rieger, H1
Heinonen, OP1
Lamberg, BA1
Virtamo, J1
DeGroot, LJ1
Benard, B1
DeWind, LT1
Hamon, CB1
Kitlak, W1
Gebert, P1
Flock, EV1
Bollman, JL1
Owen, CA1
Zollman, PE1
Sfontouris, J1
Rigopoulos, G1
Rawson, RW1
Willgerodt, H1
Löbe, J1

Reviews

5 reviews available for thyroxine and Inborn Errors of Metabolism

ArticleYear
Congenital hypothyroidism: etiologies, diagnosis, and management.
    Thyroid : official journal of the American Thyroid Association, 1999, Volume: 9, Issue:7

    Topics: Congenital Hypothyroidism; DNA-Binding Proteins; Female; Forkhead Transcription Factors; Humans; Hyp

1999
The biosynthesis of thyroid hormones.
    The South African journal of medical sciences, 1976, Volume: 41, Issue:2

    Topics: Animals; Cattle; Diiodotyrosine; Humans; Iodide Peroxidase; Iodides; Iodine; Metabolism, Inborn Erro

1976
The diagnostic use of radionuclides in the thyroid disorders of childhood.
    Seminars in nuclear medicine, 1971, Volume: 1, Issue:3

    Topics: Blood Proteins; Child; Diagnosis, Differential; Female; Fetus; Humans; Hypothyroidism; Infant, Newbo

1971
[Physiological significance of iodotyrosine-deiodinases].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Mar-01, Volume: 27, Issue:5

    Topics: Biopsy; Chemical Phenomena; Chemistry; Chromosomes; Congenital Hypothyroidism; Culture Techniques; D

1972
[Pathogenesis of various forms of arterial hypertension].
    Journal of reproduction and fertility. Supplement, 1971, Volume: 14

    Topics: Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Aging; Aortic Coarctation; Aortic Valve In

1971

Other Studies

31 other studies available for thyroxine and Inborn Errors of Metabolism

ArticleYear
Proton pump inhibitor treatment for congenital chloride diarrhea.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:3

    Topics: Adult; Amniotic Fluid; Betamethasone; Chloride-Bicarbonate Antiporters; Delivery, Obstetric; Diarrhe

2011
THE POSSIBLE OCCURRENCE OF TWO INBORN ERRORS OF IODINE METABOLISM IN ONE PATIENT.
    Acta endocrinologica, 1964, Volume: 47

    Topics: Adolescent; Child; Congenital Hypothyroidism; Diiodotyrosine; Electrophoresis; Goiter; Humans; Iodid

1964
ABSENT AND DEFECTIVE IODOTYROSINE DEIODINATION IN A FAMILY SOME OF WHOSE MEMBERS ARE GOITROUS CRETINS.
    Lancet (London, England), 1965, Jan-23, Volume: 1, Issue:7378

    Topics: Adolescent; Congenital Hypothyroidism; Enzymes; Fluids and Secretions; Genetics, Medical; Goiter; Hu

1965
HEREDITARY OROTIC ACIDURIA AND MEGALOBLASTIC ANAEMIA: A SECOND CASE, WITH RESPONSE TO URIDINE.
    British medical journal, 1965, Feb-27, Volume: 1, Issue:5434

    Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow Examination; Child; Fluids and Secret

1965
GOITROUS HYPOTHYROIDISM ASSOCIATED WITH INBORN ERRORS OF THYROXINE METABOLISM.
    Indian pediatrics, 1965, Volume: 2

    Topics: Adolescent; Child; Goiter; Humans; Hypothyroidism; Infant; Metabolism, Inborn Errors; Thyroxine

1965
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia.
    Thyroid : official journal of the American Thyroid Association, 2004, Volume: 14, Issue:2

    Topics: Adult; Amino Acid Substitution; Arginine; Artifacts; Cytosine; Dialysis; Female; Genes, Dominant; Gu

2004
Peripheral resistance to thyroid hormones.
    Clinical endocrinology, 1984, Volume: 20, Issue:3

    Topics: Humans; Metabolism, Inborn Errors; Protein Binding; Serum Albumin; Thyroid Hormones; Thyroxine; Trii

1984
Inherited thyroxine excess: a serum abnormality due to an increased affinity for modified albumin.
    Clinical endocrinology, 1981, Volume: 15, Issue:4

    Topics: Humans; Immunoelectrophoresis; Metabolism, Inborn Errors; Serum Albumin; Thyroxine; Thyroxine-Bindin

1981
Ether link cleavage is the major pathway of iodothyronine metabolism in the phagocytosing human leukocyte and also occurs in vivo in the rat.
    The Journal of clinical investigation, 1983, Volume: 71, Issue:4

    Topics: Amitrole; Animals; Catalase; Chromatography, Gel; Chromatography, Ion Exchange; Diiodotyrosine; Ethe

1983
High prevalence of thyroxine-binding globulin deficiency among Bedouin infants in southern Israel.
    Israel journal of medical sciences, 1995, Volume: 31, Issue:8

    Topics: Ethnicity; Humans; Infant, Newborn; Israel; Male; Metabolism, Inborn Errors; Prevalence; Thyrotropin

1995
Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein.
    Lancet (London, England), 1979, Mar-24, Volume: 1, Issue:8117

    Topics: Female; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Pedigree; Protein Binding; Serum Album

1979
Serum thyrotropin response to thyrotropin-releasing hormone and free thyroid hormone indices in patients with familiar thyroxine-binding globulin deficiency.
    Endocrinologia japonica, 1976, Volume: 23, Issue:4

    Topics: Adult; Aged; Female; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Serum Globulins; Thyroid

1976
Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of "inappropriate secretion of TSH".
    The Journal of clinical investigation, 1975, Volume: 56, Issue:3

    Topics: Adolescent; Child; Depression, Chemical; Dexamethasone; Female; Humans; Hyperthyroidism; Metabolism,

1975
Congenital hypothyroidism caused by defective iodide transport.
    The Journal of pediatrics, 1985, Volume: 106, Issue:6

    Topics: Biological Transport, Active; Congenital Hypothyroidism; Female; Humans; Hypothyroidism; Infant; Inf

1985
Advances in the laboratory diagnosis of thyroid disease. II.
    The Journal of pediatrics, 1973, Volume: 82, Issue:2

    Topics: Child; Graves Disease; Humans; Hyperthyroidism; Hypothyroidism; Metabolism, Inborn Errors; Radioimmu

1973
[Familial thyrosine-binding globulin deficiency. A genetic and biochemical assessment of 3 Danish families].
    Ugeskrift for laeger, 1973, May-07, Volume: 135, Issue:19

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Denmark; Female; Genotype; Humans; Male; Metabolis

1973
The influence of the plasma inorganic iodine concentration on thyroid function in dehalogenase deficiency.
    Acta endocrinologica, 1967, Volume: 55, Issue:2

    Topics: Adult; Cardiomegaly; Goiter; Humans; Hypothyroidism; Iodine; Iodine Radioisotopes; Male; Metabolism,

1967
[Goiter and hypothyroidism due to a familial defect o deiodation of iodotyrosine].
    Acta geneticae medicae et gemellologiae, 1967, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Chromatography; Diiodotyrosine; Female; Goiter; Humans; Hypothyroidism; Metabolis

1967
A case of a partial defect of the iodide trapping mechanism.
    The Journal of clinical endocrinology and metabolism, 1970, Volume: 30, Issue:3

    Topics: Age Determination by Skeleton; Child; Congenital Hypothyroidism; Diiodotyrosine; Goiter; Humans; Iod

1970
Serum lipoprotein deficiency in diffuse "normolipemic" plane xanthoma.
    Archives of dermatology, 1972, Volume: 106, Issue:4

    Topics: Adult; Biopsy; Cholesterol; Chromatography, Thin Layer; Female; Histocytochemistry; Humans; Immunodi

1972
[Diseases due to enzyme defects in childhood. Nosography and recent progress].
    Quaderni Sclavo di diagnostica clinica e di laboratorio, 1971, Volume: 7, Issue:1

    Topics: Amino Acid Metabolism, Inborn Errors; Coenzymes; Diet Therapy; Dietary Proteins; Glucose-6-Phosphata

1971
Degradation of thyroid hormones by phagocytosing human leukocytes.
    The Journal of clinical investigation, 1973, Volume: 52, Issue:1

    Topics: Ascorbic Acid; Azides; Chromatography, Gel; Chromatography, Paper; Cyanides; Electrophoresis, Paper;

1973
Inherited decrease of the binding capacity of thyroxine-binding globulin (TBG).
    Acta endocrinologica, 1970, Volume: 64, Issue:1

    Topics: Adolescent; Adult; Albumins; Child; Female; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Pr

1970
Studies of a sibship with apparent hereditary resistance to the intracellular action of thyroid hormone.
    Metabolism: clinical and experimental, 1972, Volume: 21, Issue:8

    Topics: Adolescent; Bone Diseases, Developmental; Child; Deafness; Erythrocytes; Female; Fibroblasts; Goiter

1972
Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes.
    Journal of the Reticuloendothelial Society, 1972, Volume: 12, Issue:2

    Topics: Anaerobiosis; Azides; Bacteria; Binding Sites; Blood Bactericidal Activity; Candida; Catalase; Chlor

1972
[Clinical and chromosomal studies in a congenital hypothyroidism caused by thyroxin synthesis disorders and middle ear hearing disorders (Pendred- or goiter-deafness syndrome)].
    Archiv fur Kinderheilkunde, 1968, Volume: 177, Issue:2

    Topics: Adult; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Deafness; Female; Goit

1968
Conjugation of thyroid hormones and analogs by the Gunn rat.
    Endocrinology, 1965, Volume: 77, Issue:2

    Topics: Animals; Benzoates; Bile; Biliary Fistula; Bilirubin; Chromatography, Paper; Glucosyltransferases; G

1965
Inborn errors of iodine metabolism in Greece.
    Nuclear-Medizin, 1964, Apr-01, Volume: 4, Issue:1

    Topics: Adolescent; Adult; Child; Congenital Hypothyroidism; Deafness; Female; Goiter; Greece; Humans; Hypot

1964
Physiological considerations in the management of thyroid cancer.
    Nuclear-Medizin, 1965

    Topics: 17-Ketosteroids; Adolescent; Adult; Animals; Estradiol; Estrogens; Female; Follow-Up Studies; Goiter

1965
[The need for early treatment of familial inborn errors of iodine metabolism].
    Kinderarztliche Praxis, 1966, Volume: 34, Issue:9

    Topics: Child; Female; Humans; In Vitro Techniques; Iodine Isotopes; Male; Metabolism, Inborn Errors; Thyroi

1966
Anomalous values for the half-life of radiothyroxine in dyshormonogenetic goiter.
    The Journal of clinical endocrinology and metabolism, 1966, Volume: 26, Issue:8

    Topics: Adolescent; Adult; Female; Goiter; Humans; Hyperthyroidism; Hypothyroidism; Iodine Radioisotopes; Ma

1966