thyroxine has been researched along with Hypothermia, Accidental in 46 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Myxedema coma develops as a consequence of severe hypothyroidism and is characterized by a hypometabolic, stuporous state." | 5.31 | Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog. ( Dixon, RM; Henik, RA, 2000) |
| "Myxoedema coma is fortunately rare and is probably rarer in a warm climate such as Australia." | 5.26 | A case of myxoedema coma successfully treated by low dose oral triiodothyronine. ( Graham, JJ; Harding, PE, 1977) |
| " Serum adrenocorticotropic hormone (ACTH) levels reduced at the initial phase and serum corticosterone levels decreased at nadir without any change in serum corticotropin-releasing hormone (CRH) levels throughout the hypothermia." | 3.79 | Hormonal synchronization of lipopolysaccharide-induced hypothermic response in rats. ( Akarsu, ES; Mamuk, S; Polat, H, 2013) |
| " Resting heart rate, body weight, colonic temperature and serum thyroxine (T4) were significantly lower in the treated hypothyroid rats than in the controls." | 3.67 | A time-course study of hypothyroidism-induced hypotension: its relation to hypothermia. ( Lum, L; Thompson, EB, 1986) |
| "Myxedema coma is the term given to the most severe presentation of profound hypothyroidism and is often fatal in spite of therapy." | 2.43 | Myxedema coma. ( Wartofsky, L, 2006) |
| "Myxoedema coma is a rare emergency needing prompt recognition and urgent treatment before diagnostic confirmation." | 2.36 | Myxoedema coma. A review. ( Khaleeli, A, 1978) |
| "Myxoedema coma is a rare, reversible condition with a high mortality and should be considered as a differential diagnosis in medical emergencies." | 1.42 | Complete recovery after severe myxoedema coma complicated by status epilepticus. ( Fjølner, J; Kampmann, U; Nielsen, S; Søndergaard, E, 2015) |
| "During admission, the patient developed respiratory failure, renal failure, bleeding symptoms and diffuse colitis." | 1.40 | Myxoedema coma: an almost forgotten, yet still existing cause of multiorgan failure. ( Feldt-Rasmussen, U; Laursen, AH; Reiter, N; Salomo, LH, 2014) |
| "Similarly, severe intracerebral hemorrhage (14% vs 0%; P<0." | 1.37 | [Prospective study at 1 week of life of thyroid function in 97 consecutive pre-term newborns under 32 weeks of gestation]. ( Al-Hosri, J; Bony, H; Boudailliez, B; Braun, K; Fontaine, C; Goissen, C; Léké, A; Ramadan-Ghostine, G; Tourneux, P, 2011) |
| "Myxedema coma develops as a consequence of severe hypothyroidism and is characterized by a hypometabolic, stuporous state." | 1.31 | Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog. ( Dixon, RM; Henik, RA, 2000) |
| "Eight cases of hypothyroid coma observed between 1971 and 1981 are reported, and their main clinical, biological and therapeutic features described." | 1.27 | [Myxedema coma. Apropos of 8 cases]. ( Charbonnel, B; de Rostu, H; Desjars, P, 1983) |
| "Myxoedema coma is fortunately rare and is probably rarer in a warm climate such as Australia." | 1.26 | A case of myxoedema coma successfully treated by low dose oral triiodothyronine. ( Graham, JJ; Harding, PE, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (54.35) | 18.7374 |
| 1990's | 4 (8.70) | 18.2507 |
| 2000's | 7 (15.22) | 29.6817 |
| 2010's | 10 (21.74) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tham, SW | 1 |
| Li, L | 1 |
| Effraim, P | 1 |
| Waxman, S | 1 |
| Polat, H | 1 |
| Mamuk, S | 1 |
| Akarsu, ES | 1 |
| Qi, X | 1 |
| Chan, WL | 1 |
| Read, RJ | 1 |
| Zhou, A | 1 |
| Carrell, RW | 1 |
| Salomo, LH | 1 |
| Laursen, AH | 1 |
| Reiter, N | 1 |
| Feldt-Rasmussen, U | 1 |
| SERAFIMOV, N | 1 |
| Fjølner, J | 1 |
| Søndergaard, E | 1 |
| Kampmann, U | 1 |
| Nielsen, S | 1 |
| Spyridoulias, A | 1 |
| Riaz, MS | 1 |
| Liu, K | 1 |
| Khan, H | 1 |
| Geng, X | 1 |
| Zhang, J | 1 |
| Ding, Y | 1 |
| Thompson, MD | 1 |
| Henry, RK | 1 |
| Arkader, R | 1 |
| Takeuchi, CA | 1 |
| González Castro, AM | 1 |
| López Piñeiro, S | 1 |
| Moreno López, E | 1 |
| Rodríguez Losada, M | 1 |
| Goissen, C | 1 |
| Fontaine, C | 1 |
| Braun, K | 1 |
| Bony, H | 1 |
| Al-Hosri, J | 1 |
| Ramadan-Ghostine, G | 1 |
| Léké, A | 1 |
| Boudailliez, B | 1 |
| Tourneux, P | 1 |
| Pace, A | 1 |
| McGuire, C | 1 |
| Kim, J | 1 |
| Feierabend, T | 1 |
| Chadha, S | 1 |
| Shetty, V | 1 |
| HOLVEY, DN | 1 |
| GOODNER, CJ | 1 |
| NICOLOFF, JT | 1 |
| DOWLING, JT | 1 |
| VERBOV, JL | 1 |
| BELLAU, AR | 1 |
| Scanlan, TS | 2 |
| Suchland, KL | 2 |
| Hart, ME | 1 |
| Chiellini, G | 1 |
| Huang, Y | 1 |
| Kruzich, PJ | 1 |
| Frascarelli, S | 1 |
| Crossley, DA | 1 |
| Bunzow, JR | 1 |
| Ronca-Testoni, S | 1 |
| Lin, ET | 1 |
| Hatton, D | 1 |
| Zucchi, R | 1 |
| Grandy, DK | 2 |
| Wartofsky, L | 1 |
| Doyle, KP | 1 |
| Ciesielski, TM | 1 |
| Lessov, NS | 1 |
| Stenzel-Poore, MP | 1 |
| Ward, DJ | 1 |
| Rastall, ML | 1 |
| Potter, CL | 1 |
| Sipes, IG | 1 |
| Russell, DH | 1 |
| Davis, PJ | 1 |
| Davis, FB | 1 |
| Cabello, G | 1 |
| Desjars, P | 1 |
| de Rostu, H | 1 |
| Charbonnel, B | 1 |
| Lahiri, P | 1 |
| Lahiri, S | 1 |
| Roy, B | 1 |
| Hissa, R | 1 |
| John, MT | 1 |
| Pilo, B | 1 |
| Viswanathan, M | 1 |
| George, JC | 1 |
| Fregly, MJ | 1 |
| Rossi, F | 1 |
| Cade, JR | 1 |
| Yang, Y | 1 |
| Gordon, CJ | 1 |
| Doerfler, RE | 1 |
| Edens, FW | 1 |
| Parkhurst, CR | 1 |
| Havenstein, GB | 1 |
| Qureshi, MA | 1 |
| Henik, RA | 1 |
| Dixon, RM | 1 |
| Gauthier, K | 1 |
| Plateroti, M | 1 |
| Harvey, CB | 1 |
| Williams, GR | 1 |
| Weiss, RE | 1 |
| Refetoff, S | 1 |
| Willott, JF | 1 |
| Sundin, V | 1 |
| Roux, JP | 1 |
| Malaval, L | 1 |
| Hara, M | 1 |
| Samarut, J | 1 |
| Chassande, O | 1 |
| Graham, JJ | 1 |
| Harding, PE | 1 |
| Khaleeli, A | 1 |
| Wang, LC | 1 |
| Peter, RE | 1 |
| Frankel, RJ | 1 |
| Jenkins, JS | 1 |
| Thompson, EB | 1 |
| Lum, L | 1 |
| Harvey, RF | 1 |
| Luton, JP | 1 |
| LeBlanc, J | 1 |
| Roberge, C | 1 |
| Vallière, J | 1 |
| Oakson, G | 1 |
| Cornu, P | 1 |
| Bickert, P | 1 |
| Segrestaa, JM | 1 |
| Marsan, C | 1 |
| Ertel, M | 1 |
| Manicacci, M | 1 |
| Laffay, J | 1 |
| Lamotte, M | 1 |
| Waite, R | 1 |
| Spencer, PS | 1 |
| Fisher, DA | 1 |
| Odell, WD | 1 |
| Newmark, SR | 1 |
| Himathongkam, T | 1 |
| Shane, JM | 1 |
| Blum, M | 1 |
| Woolf, PD | 1 |
| Hollander, CS | 1 |
| Mitsuma, T | 1 |
| Lee, LA | 1 |
| Schalch, DS | 1 |
| Littleton, JM | 1 |
| Ryan, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Is Levothyroxine Alone Adequate Thyroid Hormone Replacement for All Patients?[NCT02567877] | 12 participants (Actual) | Observational | 2016-11-30 | Terminated (stopped due to poor enrollment) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for thyroxine and Hypothermia, Accidental
| Article | Year |
|---|---|
Pharmacological hypothermia: a potential for future stroke therapy?
Topics: Adenine Nucleotides; Adenosine; Animals; Cannabinoids; Humans; Hypothermia; Hypothermia, Induced; Ne | 2016 |
Myxedema coma.
Topics: Aged; Coma; Female; Glucocorticoids; Humans; Hyponatremia; Hypotension; Hypothermia; Male; Myxedema; | 2006 |
Hypothyroidism in the elderly.
Topics: Aged; Aging; Anemia; Arrhythmias, Cardiac; Carcinoembryonic Antigen; Creatine Kinase; Diagnosis, Dif | 1984 |
Myxoedema coma. A review.
Topics: Acute Kidney Injury; Coma; Diagnosis, Differential; Hemorrhage; Humans; Hypoglycemia; Hyponatremia; | 1978 |
Myxedema coma.
Topics: Adrenal Glands; Cachexia; Central Nervous System; Coma; Heart Diseases; Humans; Hypoglycemia; Hypona | 1972 |
41 other studies available for thyroxine and Hypothermia, Accidental
| Article | Year |
|---|---|
Between fire and ice: refractory hypothermia and warmth-induced pain in inherited erythromelalgia.
Topics: Anti-Bacterial Agents; Child; Cold Temperature; Erythromelalgia; Female; Furosemide; Hot Temperature | 2017 |
Hormonal synchronization of lipopolysaccharide-induced hypothermic response in rats.
Topics: Adrenocorticotropic Hormone; Animals; Biomarkers; Body Temperature; Corticosterone; Cyclooxygenase I | 2013 |
Temperature-responsive release of thyroxine and its environmental adaptation in Australians.
Topics: Adaptation, Physiological; Animals; Body Temperature; Fever; Humans; Hypothermia; Mammals; Models, M | 2014 |
Myxoedema coma: an almost forgotten, yet still existing cause of multiorgan failure.
Topics: Bradycardia; Coma; Humans; Hypothermia; Macroglossia; Male; Middle Aged; Multiple Organ Failure; Myx | 2014 |
[Liberation of thyroid hormone into the thyroid vein in hypothermia in the dog].
Topics: Animals; Dogs; Epinephrine; Humans; Hypothermia; Thyroid Gland; Thyroid Hormones; Thyroxine | 1961 |
Complete recovery after severe myxoedema coma complicated by status epilepticus.
Topics: Aged; Coma; Critical Care; Female; Glasgow Coma Scale; Humans; Hypotension; Hypothermia; Myxedema; S | 2015 |
Myxoedema coma in the setting of hyperglycaemic hyperosmolar state.
Topics: Female; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Hypoglycemic Agents; Hypotension; Hypoth | 2016 |
Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics.
Topics: Agenesis of Corpus Callosum; Cerebral Cortex; Child; Chromosome Deletion; Chromosomes, Human, Pair 1 | 2017 |
Shapiro syndrome with hypothalamic hypothyroidism.
Topics: Agenesis of Corpus Callosum; Child; Cyproheptadine; Humans; Hyperhidrosis; Hypothalamic Diseases; Hy | 2008 |
[Myxedematous coma in a case of emergency herniorrhaphy].
Topics: Aged, 80 and over; Bradycardia; Coma; Comorbidity; Emergencies; Epilepsy, Generalized; Female; Herni | 2009 |
[Prospective study at 1 week of life of thyroid function in 97 consecutive pre-term newborns under 32 weeks of gestation].
Topics: Cerebral Hemorrhage; Congenital Hypothyroidism; Gestational Age; Humans; Hypothermia; Infant, Newbor | 2011 |
Osborn waves in a patient with hypothermia due to severe hypothyroidism.
Topics: Aged, 80 and over; Bradycardia; Electrocardiography; Female; Humans; Hypothermia; Hypothyroidism; Th | 2013 |
TREATMENT OF MYXEDEMA COMA WITH INTRAVENOUS THYROXINE.
Topics: Coma; Diagnosis; Geriatrics; Humans; Hypothermia; Injections, Intravenous; Myxedema; Thyroxine | 1964 |
MODERN TREATMENT OF MYXOEDEMA COMA ASSOCIATED WITH HYPOTHERMIA.
Topics: Coma; Geriatrics; Humans; Hydrocortisone; Hypothermia; Myxedema; Thyroxine; Triiodothyronine | 1964 |
THE BLOOD PRESSURE IN MYXOEDEMA COMA.
Topics: Adrenocorticotropic Hormone; Blood Pressure; Blood Pressure Determination; Body Temperature; Cholest | 1964 |
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.
Topics: Animals; Body Temperature; Brain Chemistry; Cell Line; Dose-Response Relationship, Drug; Humans; Hyp | 2004 |
Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Ischemia; Cells, Cultured; Humans; Hypothermia; I | 2007 |
Prognosis in "myxoedematous madness".
Topics: Aged; Female; Humans; Hypothermia; Mental Disorders; Myxedema; Prognosis; Thyroxine | 1967 |
Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration.
Topics: Animals; Blood Glucose; Dioxins; Glucagon; Hypothermia; Insulin; Male; Polychlorinated Dibenzodioxin | 1983 |
Endocrine reactivity (T3, T4, cortisol) during cold exposure in preterm and full-term lambs.
Topics: Animals; Animals, Newborn; Body Temperature; Cold Temperature; Gestational Age; Hydrocortisone; Hypo | 1983 |
[Myxedema coma. Apropos of 8 cases].
Topics: Aged; Coma; Female; Hemodynamics; Humans; Hyponatremia; Hypothermia; Male; Middle Aged; Myxedema; Re | 1983 |
Mitochondrial uptake of thyroid hormone in liver & heart of normothermic & hypothermic rats.
Topics: Animals; Biological Transport; Body Temperature; Hypothermia; Male; Mitochondria, Heart; Mitochondri | 1981 |
Noradrenaline-induced hypothermia is suppressed in the vagotomized cold-exposed pigeon.
Topics: Acetylcholine; Adrenal Glands; Animals; Basal Metabolism; Body Temperature; Cold Temperature; Columb | 1995 |
A role for thyroid hormones in cold-induced elevation of blood pressure and cardiac hypertrophy.
Topics: Amitrole; Animals; Blood Pressure; Cardiomegaly; Catecholamines; Cold Temperature; Hypertension; Hyp | 1994 |
Regulated hypothermia in the hypothyroid rat induced by administration of propylthiouracil.
Topics: Animals; Behavior, Animal; Body Temperature; Body Temperature Regulation; Heat Stress Disorders; Hyp | 1997 |
Hypothermia, hypoglycemia, and hypothyrosis associated with poult enteritis and mortality syndrome.
Topics: Animals; Blood Glucose; Body Temperature; Enteritis; Female; Hypoglycemia; Hypothermia; Hypothyroidi | 1998 |
Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog.
Topics: Administration, Oral; Animals; Coma; Dog Diseases; Dogs; Hypothermia; Infusions, Intravenous; Male; | 2000 |
Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus.
Topics: Animals; Bone Development; Cysteine Endopeptidases; Deafness; Down-Regulation; Embryonic and Fetal D | 2001 |
A case of myxoedema coma successfully treated by low dose oral triiodothyronine.
Topics: Aged; Coma; Humans; Hyponatremia; Hypothermia; Male; Myxedema; Respiratory Insufficiency; Thyroxine; | 1977 |
Changes in plasma glucose, FFA, corticosterone, and thyroxine in He-O2-induced hypothermia.
Topics: Animals; Blood Glucose; Body Temperature Regulation; Cold Temperature; Corticosterone; Fatty Acids, | 1977 |
Hypothalamic-pituitary function in anorexia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Blood Glucose; Female; Fever; Follicle Stimulating Hormone; Gon | 1975 |
A time-course study of hypothyroidism-induced hypotension: its relation to hypothermia.
Topics: Animals; Blood Pressure; Body Weight; Heart Rate; Hypotension; Hypothermia; Hypothyroidism; Male; Pr | 1986 |
Serum-thyroxine and thyroxine-binding globulin in seriously ill patients.
Topics: Adult; Aged; Blood Protein Electrophoresis; Body Temperature; Female; Fever; Humans; Hypothermia; Ma | 1971 |
[Unchecked thyroid insufficiencies].
Topics: Aged; Anuria; Coma; Cortisone; Female; Heating; Hemorrhage; Humans; Hypoglycemia; Hypopituitarism; H | 1969 |
The sympathetic nervous system in short-term adaptation to cold.
Topics: Adaptation, Physiological; Adrenocorticotropic Hormone; Animals; Body Temperature; Cold Temperature; | 1971 |
[Myxedema coma. Study of 3 cases].
Topics: Adrenal Insufficiency; Aged; Coma; Female; Hematologic Diseases; Humans; Hyponatremia; Hypotension; | 1973 |
The effects of tremorine and oxotremorine in hyperthyroid mice.
Topics: Animals; Body Temperature; Diarrhea; Esophagus; Hyperthyroidism; Hypothermia; Mice; Pyrrolidines; Sa | 1968 |
Effect of cold on TSH secretion in man.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Cold Temperature; Humans; Hypothalamus; Hypothermia; | 1971 |
Myxedema coma.
Topics: Administration, Oral; Adrenal Cortex Hormones; Age Factors; Aged; Coma; Emergencies; Humans; Hyponat | 1974 |
Accidental hypothermia: endocrine function during recovery.
Topics: Adult; Aged; Antigens; Blood Glucose; Body Temperature; Female; Growth Hormone; Humans; Hydrocortiso | 1972 |
Proceedings: Hypothermia produced by inhibitors of catecholamine biosynthesis.
Topics: Animals; Carbamates; Catecholamines; Dogs; Humans; Hypothermia; Methimazole; Methyltyrosines; Monoio | 1974 |