Page last updated: 2024-11-06

thyroxine and Hypothermia, Accidental

thyroxine has been researched along with Hypothermia, Accidental in 46 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"Myxedema coma develops as a consequence of severe hypothyroidism and is characterized by a hypometabolic, stuporous state."5.31Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog. ( Dixon, RM; Henik, RA, 2000)
"Myxoedema coma is fortunately rare and is probably rarer in a warm climate such as Australia."5.26A case of myxoedema coma successfully treated by low dose oral triiodothyronine. ( Graham, JJ; Harding, PE, 1977)
" Serum adrenocorticotropic hormone (ACTH) levels reduced at the initial phase and serum corticosterone levels decreased at nadir without any change in serum corticotropin-releasing hormone (CRH) levels throughout the hypothermia."3.79Hormonal synchronization of lipopolysaccharide-induced hypothermic response in rats. ( Akarsu, ES; Mamuk, S; Polat, H, 2013)
" Resting heart rate, body weight, colonic temperature and serum thyroxine (T4) were significantly lower in the treated hypothyroid rats than in the controls."3.67A time-course study of hypothyroidism-induced hypotension: its relation to hypothermia. ( Lum, L; Thompson, EB, 1986)
"Myxedema coma is the term given to the most severe presentation of profound hypothyroidism and is often fatal in spite of therapy."2.43Myxedema coma. ( Wartofsky, L, 2006)
"Myxoedema coma is a rare emergency needing prompt recognition and urgent treatment before diagnostic confirmation."2.36Myxoedema coma. A review. ( Khaleeli, A, 1978)
"Myxoedema coma is a rare, reversible condition with a high mortality and should be considered as a differential diagnosis in medical emergencies."1.42Complete recovery after severe myxoedema coma complicated by status epilepticus. ( Fjølner, J; Kampmann, U; Nielsen, S; Søndergaard, E, 2015)
"During admission, the patient developed respiratory failure, renal failure, bleeding symptoms and diffuse colitis."1.40Myxoedema coma: an almost forgotten, yet still existing cause of multiorgan failure. ( Feldt-Rasmussen, U; Laursen, AH; Reiter, N; Salomo, LH, 2014)
"Similarly, severe intracerebral hemorrhage (14% vs 0%; P<0."1.37[Prospective study at 1 week of life of thyroid function in 97 consecutive pre-term newborns under 32 weeks of gestation]. ( Al-Hosri, J; Bony, H; Boudailliez, B; Braun, K; Fontaine, C; Goissen, C; Léké, A; Ramadan-Ghostine, G; Tourneux, P, 2011)
"Myxedema coma develops as a consequence of severe hypothyroidism and is characterized by a hypometabolic, stuporous state."1.31Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog. ( Dixon, RM; Henik, RA, 2000)
"Eight cases of hypothyroid coma observed between 1971 and 1981 are reported, and their main clinical, biological and therapeutic features described."1.27[Myxedema coma. Apropos of 8 cases]. ( Charbonnel, B; de Rostu, H; Desjars, P, 1983)
"Myxoedema coma is fortunately rare and is probably rarer in a warm climate such as Australia."1.26A case of myxoedema coma successfully treated by low dose oral triiodothyronine. ( Graham, JJ; Harding, PE, 1977)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199025 (54.35)18.7374
1990's4 (8.70)18.2507
2000's7 (15.22)29.6817
2010's10 (21.74)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tham, SW1
Li, L1
Effraim, P1
Waxman, S1
Polat, H1
Mamuk, S1
Akarsu, ES1
Qi, X1
Chan, WL1
Read, RJ1
Zhou, A1
Carrell, RW1
Salomo, LH1
Laursen, AH1
Reiter, N1
Feldt-Rasmussen, U1
SERAFIMOV, N1
Fjølner, J1
Søndergaard, E1
Kampmann, U1
Nielsen, S1
Spyridoulias, A1
Riaz, MS1
Liu, K1
Khan, H1
Geng, X1
Zhang, J1
Ding, Y1
Thompson, MD1
Henry, RK1
Arkader, R1
Takeuchi, CA1
González Castro, AM1
López Piñeiro, S1
Moreno López, E1
Rodríguez Losada, M1
Goissen, C1
Fontaine, C1
Braun, K1
Bony, H1
Al-Hosri, J1
Ramadan-Ghostine, G1
Léké, A1
Boudailliez, B1
Tourneux, P1
Pace, A1
McGuire, C1
Kim, J1
Feierabend, T1
Chadha, S1
Shetty, V1
HOLVEY, DN1
GOODNER, CJ1
NICOLOFF, JT1
DOWLING, JT1
VERBOV, JL1
BELLAU, AR1
Scanlan, TS2
Suchland, KL2
Hart, ME1
Chiellini, G1
Huang, Y1
Kruzich, PJ1
Frascarelli, S1
Crossley, DA1
Bunzow, JR1
Ronca-Testoni, S1
Lin, ET1
Hatton, D1
Zucchi, R1
Grandy, DK2
Wartofsky, L1
Doyle, KP1
Ciesielski, TM1
Lessov, NS1
Stenzel-Poore, MP1
Ward, DJ1
Rastall, ML1
Potter, CL1
Sipes, IG1
Russell, DH1
Davis, PJ1
Davis, FB1
Cabello, G1
Desjars, P1
de Rostu, H1
Charbonnel, B1
Lahiri, P1
Lahiri, S1
Roy, B1
Hissa, R1
John, MT1
Pilo, B1
Viswanathan, M1
George, JC1
Fregly, MJ1
Rossi, F1
Cade, JR1
Yang, Y1
Gordon, CJ1
Doerfler, RE1
Edens, FW1
Parkhurst, CR1
Havenstein, GB1
Qureshi, MA1
Henik, RA1
Dixon, RM1
Gauthier, K1
Plateroti, M1
Harvey, CB1
Williams, GR1
Weiss, RE1
Refetoff, S1
Willott, JF1
Sundin, V1
Roux, JP1
Malaval, L1
Hara, M1
Samarut, J1
Chassande, O1
Graham, JJ1
Harding, PE1
Khaleeli, A1
Wang, LC1
Peter, RE1
Frankel, RJ1
Jenkins, JS1
Thompson, EB1
Lum, L1
Harvey, RF1
Luton, JP1
LeBlanc, J1
Roberge, C1
Vallière, J1
Oakson, G1
Cornu, P1
Bickert, P1
Segrestaa, JM1
Marsan, C1
Ertel, M1
Manicacci, M1
Laffay, J1
Lamotte, M1
Waite, R1
Spencer, PS1
Fisher, DA1
Odell, WD1
Newmark, SR1
Himathongkam, T1
Shane, JM1
Blum, M1
Woolf, PD1
Hollander, CS1
Mitsuma, T1
Lee, LA1
Schalch, DS1
Littleton, JM1
Ryan, SM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Is Levothyroxine Alone Adequate Thyroid Hormone Replacement for All Patients?[NCT02567877]12 participants (Actual)Observational2016-11-30Terminated (stopped due to poor enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for thyroxine and Hypothermia, Accidental

ArticleYear
Pharmacological hypothermia: a potential for future stroke therapy?
    Neurological research, 2016, Volume: 38, Issue:6

    Topics: Adenine Nucleotides; Adenosine; Animals; Cannabinoids; Humans; Hypothermia; Hypothermia, Induced; Ne

2016
Myxedema coma.
    Endocrinology and metabolism clinics of North America, 2006, Volume: 35, Issue:4

    Topics: Aged; Coma; Female; Glucocorticoids; Humans; Hyponatremia; Hypotension; Hypothermia; Male; Myxedema;

2006
Hypothyroidism in the elderly.
    Comprehensive therapy, 1984, Volume: 10, Issue:4

    Topics: Aged; Aging; Anemia; Arrhythmias, Cardiac; Carcinoembryonic Antigen; Creatine Kinase; Diagnosis, Dif

1984
Myxoedema coma. A review.
    Pahlavi medical journal, 1978, Volume: 9, Issue:2

    Topics: Acute Kidney Injury; Coma; Diagnosis, Differential; Hemorrhage; Humans; Hypoglycemia; Hyponatremia;

1978
Myxedema coma.
    The American journal of the medical sciences, 1972, Volume: 264, Issue:6

    Topics: Adrenal Glands; Cachexia; Central Nervous System; Coma; Heart Diseases; Humans; Hypoglycemia; Hypona

1972

Other Studies

41 other studies available for thyroxine and Hypothermia, Accidental

ArticleYear
Between fire and ice: refractory hypothermia and warmth-induced pain in inherited erythromelalgia.
    BMJ case reports, 2017, Jul-26, Volume: 2017

    Topics: Anti-Bacterial Agents; Child; Cold Temperature; Erythromelalgia; Female; Furosemide; Hot Temperature

2017
Hormonal synchronization of lipopolysaccharide-induced hypothermic response in rats.
    Journal of endocrinological investigation, 2013, Volume: 36, Issue:10

    Topics: Adrenocorticotropic Hormone; Animals; Biomarkers; Body Temperature; Corticosterone; Cyclooxygenase I

2013
Temperature-responsive release of thyroxine and its environmental adaptation in Australians.
    Proceedings. Biological sciences, 2014, Mar-22, Volume: 281, Issue:1779

    Topics: Adaptation, Physiological; Animals; Body Temperature; Fever; Humans; Hypothermia; Mammals; Models, M

2014
Myxoedema coma: an almost forgotten, yet still existing cause of multiorgan failure.
    BMJ case reports, 2014, Jan-30, Volume: 2014

    Topics: Bradycardia; Coma; Humans; Hypothermia; Macroglossia; Male; Middle Aged; Multiple Organ Failure; Myx

2014
[Liberation of thyroid hormone into the thyroid vein in hypothermia in the dog].
    Primena radioaktivnih izotopa i jonizujucih zracenja u medicini; bilten, 1961, Volume: 2

    Topics: Animals; Dogs; Epinephrine; Humans; Hypothermia; Thyroid Gland; Thyroid Hormones; Thyroxine

1961
Complete recovery after severe myxoedema coma complicated by status epilepticus.
    BMJ case reports, 2015, Mar-25, Volume: 2015

    Topics: Aged; Coma; Critical Care; Female; Glasgow Coma Scale; Humans; Hypotension; Hypothermia; Myxedema; S

2015
Myxoedema coma in the setting of hyperglycaemic hyperosmolar state.
    BMJ case reports, 2016, Jan-11, Volume: 2016

    Topics: Female; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Hypoglycemic Agents; Hypotension; Hypoth

2016
Myxedema Coma Secondary to Central Hypothyroidism: A Rare but Real Cause of Altered Mental Status in Pediatrics.
    Hormone research in paediatrics, 2017, Volume: 87, Issue:5

    Topics: Agenesis of Corpus Callosum; Cerebral Cortex; Child; Chromosome Deletion; Chromosomes, Human, Pair 1

2017
Shapiro syndrome with hypothalamic hypothyroidism.
    Arquivos de neuro-psiquiatria, 2008, Volume: 66, Issue:2B

    Topics: Agenesis of Corpus Callosum; Child; Cyproheptadine; Humans; Hyperhidrosis; Hypothalamic Diseases; Hy

2008
[Myxedematous coma in a case of emergency herniorrhaphy].
    Revista espanola de anestesiologia y reanimacion, 2009, Volume: 56, Issue:5

    Topics: Aged, 80 and over; Bradycardia; Coma; Comorbidity; Emergencies; Epilepsy, Generalized; Female; Herni

2009
[Prospective study at 1 week of life of thyroid function in 97 consecutive pre-term newborns under 32 weeks of gestation].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2011, Volume: 18, Issue:3

    Topics: Cerebral Hemorrhage; Congenital Hypothyroidism; Gestational Age; Humans; Hypothermia; Infant, Newbor

2011
Osborn waves in a patient with hypothermia due to severe hypothyroidism.
    QJM : monthly journal of the Association of Physicians, 2013, Volume: 106, Issue:12

    Topics: Aged, 80 and over; Bradycardia; Electrocardiography; Female; Humans; Hypothermia; Hypothyroidism; Th

2013
TREATMENT OF MYXEDEMA COMA WITH INTRAVENOUS THYROXINE.
    Archives of internal medicine, 1964, Volume: 113

    Topics: Coma; Diagnosis; Geriatrics; Humans; Hypothermia; Injections, Intravenous; Myxedema; Thyroxine

1964
MODERN TREATMENT OF MYXOEDEMA COMA ASSOCIATED WITH HYPOTHERMIA.
    Lancet (London, England), 1964, Jan-25, Volume: 1, Issue:7326

    Topics: Coma; Geriatrics; Humans; Hydrocortisone; Hypothermia; Myxedema; Thyroxine; Triiodothyronine

1964
THE BLOOD PRESSURE IN MYXOEDEMA COMA.
    The British journal of clinical practice, 1964, Volume: 18

    Topics: Adrenocorticotropic Hormone; Blood Pressure; Blood Pressure Determination; Body Temperature; Cholest

1964
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.
    Nature medicine, 2004, Volume: 10, Issue:6

    Topics: Animals; Body Temperature; Brain Chemistry; Cell Line; Dose-Response Relationship, Drug; Humans; Hyp

2004
Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury.
    Stroke, 2007, Volume: 38, Issue:9

    Topics: Animals; Behavior, Animal; Body Temperature; Brain Ischemia; Cells, Cultured; Humans; Hypothermia; I

2007
Prognosis in "myxoedematous madness".
    The British journal of psychiatry : the journal of mental science, 1967, Volume: 113, Issue:495

    Topics: Aged; Female; Humans; Hypothermia; Mental Disorders; Myxedema; Prognosis; Thyroxine

1967
Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration.
    Toxicology and applied pharmacology, 1983, Jun-15, Volume: 69, Issue:1

    Topics: Animals; Blood Glucose; Dioxins; Glucagon; Hypothermia; Insulin; Male; Polychlorinated Dibenzodioxin

1983
Endocrine reactivity (T3, T4, cortisol) during cold exposure in preterm and full-term lambs.
    Biology of the neonate, 1983, Volume: 44, Issue:4

    Topics: Animals; Animals, Newborn; Body Temperature; Cold Temperature; Gestational Age; Hydrocortisone; Hypo

1983
[Myxedema coma. Apropos of 8 cases].
    La Revue de medecine interne, 1983, Volume: 4, Issue:3

    Topics: Aged; Coma; Female; Hemodynamics; Humans; Hyponatremia; Hypothermia; Male; Middle Aged; Myxedema; Re

1983
Mitochondrial uptake of thyroid hormone in liver & heart of normothermic & hypothermic rats.
    Indian journal of experimental biology, 1981, Volume: 19, Issue:7

    Topics: Animals; Biological Transport; Body Temperature; Hypothermia; Male; Mitochondria, Heart; Mitochondri

1981
Noradrenaline-induced hypothermia is suppressed in the vagotomized cold-exposed pigeon.
    Comparative biochemistry and physiology. Part A, Physiology, 1995, Volume: 111, Issue:1

    Topics: Acetylcholine; Adrenal Glands; Animals; Basal Metabolism; Body Temperature; Cold Temperature; Columb

1995
A role for thyroid hormones in cold-induced elevation of blood pressure and cardiac hypertrophy.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:9

    Topics: Amitrole; Animals; Blood Pressure; Cardiomegaly; Catecholamines; Cold Temperature; Hypertension; Hyp

1994
Regulated hypothermia in the hypothyroid rat induced by administration of propylthiouracil.
    The American journal of physiology, 1997, Volume: 272, Issue:5 Pt 2

    Topics: Animals; Behavior, Animal; Body Temperature; Body Temperature Regulation; Heat Stress Disorders; Hyp

1997
Hypothermia, hypoglycemia, and hypothyrosis associated with poult enteritis and mortality syndrome.
    Poultry science, 1998, Volume: 77, Issue:8

    Topics: Animals; Blood Glucose; Body Temperature; Enteritis; Female; Hypoglycemia; Hypothermia; Hypothyroidi

1998
Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog.
    Journal of the American Veterinary Medical Association, 2000, Mar-01, Volume: 216, Issue:5

    Topics: Administration, Oral; Animals; Coma; Dog Diseases; Dogs; Hypothermia; Infusions, Intravenous; Male;

2000
Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus.
    Molecular and cellular biology, 2001, Volume: 21, Issue:14

    Topics: Animals; Bone Development; Cysteine Endopeptidases; Deafness; Down-Regulation; Embryonic and Fetal D

2001
A case of myxoedema coma successfully treated by low dose oral triiodothyronine.
    Australian and New Zealand journal of medicine, 1977, Volume: 7, Issue:2

    Topics: Aged; Coma; Humans; Hyponatremia; Hypothermia; Male; Myxedema; Respiratory Insufficiency; Thyroxine;

1977
Changes in plasma glucose, FFA, corticosterone, and thyroxine in He-O2-induced hypothermia.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1977, Volume: 42, Issue:5

    Topics: Animals; Blood Glucose; Body Temperature Regulation; Cold Temperature; Corticosterone; Fatty Acids,

1977
Hypothalamic-pituitary function in anorexia nervosa.
    Acta endocrinologica, 1975, Volume: 78, Issue:2

    Topics: Adolescent; Adult; Anorexia Nervosa; Blood Glucose; Female; Fever; Follicle Stimulating Hormone; Gon

1975
A time-course study of hypothyroidism-induced hypotension: its relation to hypothermia.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 283, Issue:1

    Topics: Animals; Blood Pressure; Body Weight; Heart Rate; Hypotension; Hypothermia; Hypothyroidism; Male; Pr

1986
Serum-thyroxine and thyroxine-binding globulin in seriously ill patients.
    Lancet (London, England), 1971, Jan-30, Volume: 1, Issue:7692

    Topics: Adult; Aged; Blood Protein Electrophoresis; Body Temperature; Female; Fever; Humans; Hypothermia; Ma

1971
[Unchecked thyroid insufficiencies].
    La Presse medicale, 1969, Jun-25, Volume: 77, Issue:31

    Topics: Aged; Anuria; Coma; Cortisone; Female; Heating; Hemorrhage; Humans; Hypoglycemia; Hypopituitarism; H

1969
The sympathetic nervous system in short-term adaptation to cold.
    Canadian journal of physiology and pharmacology, 1971, Volume: 49, Issue:2

    Topics: Adaptation, Physiological; Adrenocorticotropic Hormone; Animals; Body Temperature; Cold Temperature;

1971
[Myxedema coma. Study of 3 cases].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1973, Apr-26, Volume: 49, Issue:20

    Topics: Adrenal Insufficiency; Aged; Coma; Female; Hematologic Diseases; Humans; Hyponatremia; Hypotension;

1973
The effects of tremorine and oxotremorine in hyperthyroid mice.
    The Journal of pharmacy and pharmacology, 1968, Volume: 20, Issue:3

    Topics: Animals; Body Temperature; Diarrhea; Esophagus; Hyperthyroidism; Hypothermia; Mice; Pyrrolidines; Sa

1968
Effect of cold on TSH secretion in man.
    The Journal of clinical endocrinology and metabolism, 1971, Volume: 33, Issue:5

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Cold Temperature; Humans; Hypothalamus; Hypothermia;

1971
Myxedema coma.
    JAMA, 1974, Nov-11, Volume: 230, Issue:6

    Topics: Administration, Oral; Adrenal Cortex Hormones; Age Factors; Aged; Coma; Emergencies; Humans; Hyponat

1974
Accidental hypothermia: endocrine function during recovery.
    The Journal of clinical endocrinology and metabolism, 1972, Volume: 34, Issue:3

    Topics: Adult; Aged; Antigens; Blood Glucose; Body Temperature; Female; Growth Hormone; Humans; Hydrocortiso

1972
Proceedings: Hypothermia produced by inhibitors of catecholamine biosynthesis.
    British journal of pharmacology, 1974, Volume: 50, Issue:3

    Topics: Animals; Carbamates; Catecholamines; Dogs; Humans; Hypothermia; Methimazole; Methyltyrosines; Monoio

1974