Page last updated: 2024-11-06

thyroxine and Hypocalcemia

thyroxine has been researched along with Hypocalcemia in 40 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Celiac disease was confirmed by elevated serum antigliadin antibody."5.33[Autoimmune hypothyroidism nonresponsive to high doses of levothyroxine and severe hypocalcemia]. ( Silva, CM; Souza, MV, 2005)
" To prevent recurrence of a multinodular goiter, supplementation with iodine is strongly recommended."4.84[Surgical resection of the thyroid and parathyroid glands]. ( Bollheimer, LC; Büttner, R; Woenckhaus, U, 2007)
" Thyroid indices while maintained on levothyroxine were normal, but marked asymptomatic hypocalcemia with an inappropriately normal parathyroid hormone level was noted."3.81Early Hypoparathyroidism Reversibility with Treatment of Riedel's Thyroiditis. ( Drake, MT; Haglind, EG; Stan, MN, 2015)
"Bilateral thyroidectomy, elevated free thyroxine level, and parathyroid autotransplantation are independent risk factors for postthyroidectomy hypocalcemia."3.71Risk factors for postthyroidectomy hypocalcemia. ( Abboud, B; Akkam, M; Sargi, Z; Sleilaty, F, 2002)
"To investigate the pathogenesis of post-thyroidectomy hypocalcemia calcium, phosphate, calcitonin, parathormone, albumin, triiodothyronine and thyroxine levels were monitored during operation and postoperatively in 25 female patients undergoing bilateral subtotal thyroidectomy for non-toxic nodular goiter."3.69Post-thyroidectomy hypocalcemia: the role of calcitonin, parathormone and serum albumin. ( Bumin, C; Cakmakli, S; Cavusoglu, T; Torun, N, 1996)
"Patients with thyrotoxicosis are prone to transient hypocalcemia after thyroidectomy, which may be due in part to surgical damage to the parathyroid glands."2.72Hungry Bone Syndrome Secondary to Subtotal Thyroidectomy in A Patient With Thyrotoxicosis. ( Guo, Z; Mo, Z; Xie, Y; Yan, Y; Zhao, L, 2021)
"Hypothyroidism and hypocalcemia are common after thyroid and parathyroid surgery."2.46Hormone replacement after thyroid and parathyroid surgery. ( Schäffler, A, 2010)
"Celiac disease was confirmed by elevated serum antigliadin antibody."1.33[Autoimmune hypothyroidism nonresponsive to high doses of levothyroxine and severe hypocalcemia]. ( Silva, CM; Souza, MV, 2005)
"Transient recurrent laryngeal nerve palsy developed in 1 patient both in DP and TT group."1.32Comparison of different thyroidectomy techniques for benign thyroid disease. ( Aydin, C; Budak, E; Dökmetas, HS; Gökgöz, S; Karadayi, K; Koyuncu, A; Sen, M; Turan, M, 2003)
" We present a dihydrotachysterol-calcium treated patient with post-operative hypothyroidism, who developed hypercalcaemia, when the thyroxine dosage was increased."1.27Hypercalcaemia induced by increased thyroxine substitution in a patient treated with dihydrotachysterol. ( Dymling, JF; Hallengren, B; Spjuth, J, 1984)
" There was no significant difference in the dose of PTE required to attain normocalcemia nor in the dose-response relations between the plasma calcium concentration and the PTE dose."1.25Pathogenesis of hypocalcemia in magnesium depletion. Normal end-organ responsiveness to parathyroid hormone. ( Csima, A; Fraser, D; Suh, SM, 1971)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199023 (57.50)18.7374
1990's4 (10.00)18.2507
2000's9 (22.50)29.6817
2010's3 (7.50)24.3611
2020's1 (2.50)2.80

Authors

AuthorsStudies
Guo, Z1
Zhao, L1
Xie, Y1
Yan, Y1
Mo, Z1
Stan, MN1
Haglind, EG1
Drake, MT1
Rariy, CM1
Schram, A1
Ruan, DT1
Vaidya, A1
Alexander, E1
Schäffler, A1
Abboud, B1
Sargi, Z1
Akkam, M1
Sleilaty, F1
Koyuncu, A1
Dökmetas, HS1
Turan, M1
Aydin, C1
Karadayi, K1
Budak, E1
Gökgöz, S1
Sen, M1
Ozbas, S1
Kocak, S1
Aydintug, S1
Cakmak, A1
Demirkiran, MA1
Wishart, GC1
Silva, CM1
Souza, MV1
Woenckhaus, U1
Büttner, R1
Bollheimer, LC1
Lam, J1
Maragaño, P1
Lépez, B1
Vásquez, L1
Erbil, Y1
Ozbey, N1
Giriş, M1
Salmaslioğlu, A1
Ozarmağan, S1
Tezelman, S1
Coiro, V1
Zanardi, G1
Saccani Jotti, G1
Rubino, P1
Manfredi, G1
Chiodera, P1
Danowski, J1
Hallengren, B1
Spjuth, J1
Dymling, JF1
Richards, GE1
Brewer, ED1
Conley, SB1
Saldana, LR1
Holzworth, J1
Theran, P1
Carpenter, JL1
Harpster, NK1
Todoroff, RJ1
Chardin, H1
Acevedo, AC1
Septier, D1
Staub, JF1
Goldberg, M1
Finco, DR1
Brown, SA1
Ferguson, DC1
Crowell, WA1
Cakmakli, S1
Cavusoglu, T1
Bumin, C1
Torun, N1
Lindblom, P1
Westerdahl, J1
Bergenfelz, A1
Heimann, P1
Martinson, J1
Tonini, G1
Tecilazich, D1
Bertoli, G1
Di Giacomo, BE1
Mangiarotti Marchi, MA1
Nordio, S1
Carlson, HE1
Brickman, AS1
Hillman, D1
Bolenbaugh, DL1
Convey, EM1
Kalisnik, M1
Zorc-Pleskovic, R1
Pajer, Z1
Pavlin, K1
Barajas de Frutos, D1
Pedrero Vera, J1
Bolívar Barrales, JE1
Espigares Martín, R1
Ortega Martos, L1
Vílchez Joya, R1
Bolívar Galiano, V1
Morell Bernabé, JJ1
Cabello, G1
Wrutniak, C1
Moynihan, GD1
Ruppe, JP1
Suh, SM2
Kooh, SW1
Chan, AM1
Fraser, D2
Tashjian, AH1
Van Nguyen, V1
Jowsey, J2
Bénichou, C1
Méry, C1
D'Souza, A1
Floch, MH1
Barlet, JP2
Godenèche, D1
Jourde, H1
Michelot, J1
Milhaud, G1
Tsien-Ming, L1
Moukhtar, MS1
Csima, A1
Swynghedauw, B1
Hatt, PY1
Klein, DC1
Talmage, RV1
Simons, GW1
Blahos, J1
Blahosová, A1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Routine Prophylactic Calcium + Calcitriol and Selective Use Based on PTH for the Prevention of Postoperative Hypocalcemia in Patients With Total Thyroidectomy. Randomized Clinical Trial[NCT05252884]180 participants (Anticipated)Interventional2022-03-30Not yet recruiting
Study for Effectiveness in Prevention of Postoperative Hypocalcemia of Preoperative Oral Supplementation of Vitamin D (D-mac 30,000 IU) in Patients Undergoing Total Thyroidectomy[NCT05216419]Phase 4108 participants (Anticipated)Interventional2021-06-07Recruiting
Five-year Follow up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter.[NCT00946894]600 participants (Actual)Interventional2000-01-31Completed
Subtotal Versus Total Thyroidectomy for Benign Thyroid Disease - a Prospective Case-control Surgical Outcome Study.[NCT01273714]8,006 participants (Actual)Interventional1999-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for thyroxine and Hypocalcemia

ArticleYear
Hungry Bone Syndrome Secondary to Subtotal Thyroidectomy in A Patient With Thyrotoxicosis.
    The American journal of the medical sciences, 2021, Volume: 362, Issue:3

    Topics: Adult; Calcitriol; Female; Humans; Hypocalcemia; Hypothyroidism; Postoperative Complications; Syndro

2021
Hormone replacement after thyroid and parathyroid surgery.
    Deutsches Arzteblatt international, 2010, Volume: 107, Issue:47

    Topics: Administration, Oral; Calcium Carbonate; Calcium Citrate; Calcium Gluconate; Dose-Response Relations

2010
[Surgical resection of the thyroid and parathyroid glands].
    Der Internist, 2007, Volume: 48, Issue:6

    Topics: Goiter; Humans; Hyperparathyroidism; Hypocalcemia; Iodine; Parathyroidectomy; Thyroidectomy; Thyroxi

2007
[Current theories on the role of thyroid hormones in the pathomechanism of allergy].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1983, Oct-03, Volume: 38, Issue:40

    Topics: Anaphylaxis; Animals; Asthma; Calcitonin; Guinea Pigs; Humans; Hyperthyroidism; Hypocalcemia; Thyrox

1983
[Aspects of the hypothalamo-hypophyseal function in children].
    Minerva medica, 1979, Jun-16, Volume: 70, Issue:28

    Topics: Adolescent; Arginine; Calcium; Child; Clomiphene; Gonadotropins; Growth Disorders; Growth Hormone; H

1979
Calcium metabolism in pancreatic disease.
    The American journal of clinical nutrition, 1973, Volume: 26, Issue:3

    Topics: Acute Disease; Adult; Animals; Calcitonin; Calcium; Calcium, Dietary; Cholecalciferol; Chronic Disea

1973

Trials

2 trials available for thyroxine and Hypocalcemia

ArticleYear
High-calcium mineral water as a calcium supplementing measure for post-thyroidectomy hypocalcemia.
    Minerva endocrinologica, 2008, Volume: 33, Issue:1

    Topics: Adult; Calcitriol; Calcium; Calcium Compounds; Carbonates; Cross-Over Studies; Dose-Response Relatio

2008
Hemithyroidectomy: long-term effects on parathyroid function--preliminary report.
    World journal of surgery, 2001, Volume: 25, Issue:9

    Topics: Adult; Calcitriol; Calcium; Euthyroid Sick Syndromes; Female; Follow-Up Studies; Homeostasis; Humans

2001

Other Studies

32 other studies available for thyroxine and Hypocalcemia

ArticleYear
Early Hypoparathyroidism Reversibility with Treatment of Riedel's Thyroiditis.
    Thyroid : official journal of the American Thyroid Association, 2015, Volume: 25, Issue:9

    Topics: Adult; Africa; Biopsy, Fine-Needle; Female; Goiter; Humans; Hypocalcemia; Hypoparathyroidism; Inflam

2015
INTERACTIVE MEDICAL CASE. A Man with Bizarre Behavior.
    The New England journal of medicine, 2015, Aug-13, Volume: 373, Issue:7

    Topics: Diagnosis, Differential; Graves Disease; Humans; Hypocalcemia; Hypoparathyroidism; Male; Postoperati

2015
Risk factors for postthyroidectomy hypocalcemia.
    Journal of the American College of Surgeons, 2002, Volume: 195, Issue:4

    Topics: Adolescent; Adult; Aged; Calcium; Female; Humans; Hypocalcemia; Male; Middle Aged; Multivariate Anal

2002
Comparison of different thyroidectomy techniques for benign thyroid disease.
    Endocrine journal, 2003, Volume: 50, Issue:6

    Topics: Adolescent; Adult; Aged; Carcinoma, Papillary; Female; Follow-Up Studies; Humans; Hypocalcemia; Male

2003
Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Adult; Goiter, Nodular; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Postoperative Complic

2005
Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Adult; Goiter, Nodular; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Postoperative Complic

2005
Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Adult; Goiter, Nodular; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Postoperative Complic

2005
Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Adult; Goiter, Nodular; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Postoperative Complic

2005
Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Adult; Goiter, Nodular; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Postoperative Complic

2005
Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Adult; Goiter, Nodular; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Postoperative Complic

2005
Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Adult; Goiter, Nodular; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Postoperative Complic

2005
Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Adult; Goiter, Nodular; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Postoperative Complic

2005
Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Adult; Goiter, Nodular; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Postoperative Complic

2005
[Autoimmune hypothyroidism nonresponsive to high doses of levothyroxine and severe hypocalcemia].
    Arquivos brasileiros de endocrinologia e metabologia, 2005, Volume: 49, Issue:4

    Topics: Celiac Disease; Drug Resistance; Female; Hashimoto Disease; Humans; Hypocalcemia; Middle Aged; Sever

2005
[Hypocalcemic cardiomyopathy secondary to hypoparathyroidism after a thyroidectomy: report of one case].
    Revista medica de Chile, 2007, Volume: 135, Issue:3

    Topics: Adult; Calcium; Chronic Disease; Diagnosis, Differential; Female; Heart Failure; Humans; Hypocalcemi

2007
Effects of thyroxine replacement on lipid profile and endothelial function after thyroidectomy.
    The British journal of surgery, 2007, Volume: 94, Issue:12

    Topics: Adult; Cholesterol; Endothelium, Vascular; Female; Goiter, Nodular; Humans; Hypocalcemia; Male; Midd

2007
Hypercalcaemia induced by increased thyroxine substitution in a patient treated with dihydrotachysterol.
    Acta endocrinologica, 1984, Volume: 105, Issue:1

    Topics: Calcium; Dihydrotachysterol; Female; Humans; Hypercalcemia; Hypocalcemia; Hypothyroidism; Middle Age

1984
Combined hypothyroidism and hypoparathyroidism in an infant after maternal 131I administration.
    The Journal of pediatrics, 1981, Volume: 99, Issue:1

    Topics: Carcinoma; Female; Humans; Hypocalcemia; Hypoparathyroidism; Hypothyroidism; Infant; Infant, Newborn

1981
Hyperthyroidism in the cat: ten cases.
    Journal of the American Veterinary Medical Association, 1980, Feb-15, Volume: 176, Issue:4

    Topics: Animals; Cat Diseases; Cats; Female; Heart Diseases; Hyperthyroidism; Hypocalcemia; Male; Postoperat

1980
Effects of thyro-parathyroidectomy and parathyroidectomy upon dentinogenesis: Part I: Light microscopy.
    Connective tissue research, 1995, Volume: 32, Issue:1-4

    Topics: Animals; Body Weight; Calcium; Dentin; Dentinogenesis; Hypocalcemia; Incisor; Male; Parathyroid Glan

1995
Selective parathyroidectomy of the dog.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 1993, Volume: 57, Issue:4

    Topics: Animals; Calcium; Dog Diseases; Dogs; Female; Hypocalcemia; Kidney Failure, Chronic; Male; Parathyro

1993
Post-thyroidectomy hypocalcemia: the role of calcitonin, parathormone and serum albumin.
    The Tokai journal of experimental and clinical medicine, 1996, Volume: 21, Issue:2

    Topics: Calcitonin; Female; Goiter, Nodular; Humans; Hypocalcemia; Parathyroid Hormone; Phosphates; Postoper

1996
Surgical treatment of thyrotoxicosis: results of 272 operations with special reference to preoperative treatment with anti-thyroid drugs and L-thyroxine.
    The British journal of surgery, 1975, Volume: 62, Issue:9

    Topics: Adolescent; Adult; Aged; Antithyroid Agents; Carbimazole; Child; Female; Goiter; Humans; Hyperthyroi

1975
Effect of hypocalcemia on hormonal responses to thyrotropin-releasing hormone.
    The Journal of clinical endocrinology and metabolism, 1977, Volume: 45, Issue:2

    Topics: Adolescent; Adult; Child; Female; Humans; Hypocalcemia; Hypoparathyroidism; Hypothyroidism; Kinetics

1977
Hypothyroidism and anemia related to fluoride in dairy cattle.
    Journal of dairy science, 1979, Volume: 62, Issue:3

    Topics: Anemia; Animals; Cattle; Cattle Diseases; Cholesterol; Eosinophilia; Exostoses; Female; Fluoride Poi

1979
The effect of chronic hypercalcemia or hypocalcemia on the follicular and parafollicular cells in rat thyroid gland.
    The American journal of anatomy, 1990, Volume: 189, Issue:3

    Topics: Animals; Calcium; Chronic Disease; Female; Hypercalcemia; Hypocalcemia; Radioimmunoassay; Rats; Rats

1990
[Parathyroid insufficiency syndrome. Two new cases: type Ia pseudohypoparathyroidism and pseudo-idiopathic hypoparathyroidism].
    Anales espanoles de pediatria, 1989, Volume: 31, Issue:4

    Topics: Calcitriol; Calcium; Child; Cyclic AMP; Female; Humans; Hypocalcemia; Hypoparathyroidism; Male; Para

1989
Effects of transient, corrected ovine maternal hypocalcaemia on neonatal endocrine and metabolic function.
    Research in veterinary science, 1989, Volume: 47, Issue:1

    Topics: Animals; Animals, Newborn; Blood Glucose; Fatty Acids, Nonesterified; Female; Hydrocortisone; Hypoca

1989
Impetigo herpetiformis and hypoparathyroidism.
    Archives of dermatology, 1985, Volume: 121, Issue:10

    Topics: Calcium; Female; Herpesviridae Infections; Humans; Hypocalcemia; Hypoparathyroidism; Impetigo; Middl

1985
Pseudohypoparathyroidism: no improvement following total thyroidectomy.
    The Journal of clinical endocrinology and metabolism, 1969, Volume: 29, Issue:4

    Topics: Calcitonin; Calcium; Child; Cholesterol; Female; Humans; Hypocalcemia; Iodine Radioisotopes; Parathy

1969
Bone metabolism. The acute effects of hormones, vitamin D3, and acidosis during in vivo perfusion ff adult dog forelimbs.
    The Journal of bone and joint surgery. American volume, 1970, Volume: 52, Issue:5

    Topics: Acidosis; Alkaline Phosphatase; Animals; Bone and Bones; Bone Development; Bone Resorption; Calciton

1970
[Iodinated thyroid hormones and phosphocalcic metabolism].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1971, May-26, Volume: 47, Issue:25

    Topics: Bone Diseases; Calcitonin; Calcium; Calcium Metabolism Disorders; Humans; Hypercalcemia; Hyperthyroi

1971
Calcitonin and iodinated hormones in sheep.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1973, Volume: 5, Issue:6

    Topics: Animals; Blood Proteins; Calcitonin; Calcium; Female; Hypocalcemia; Pregnancy; Protein Binding; Shee

1973
[Synergism and antagonism of thyroxine, parathormone and thyrocalcitonin on calcemia and phosphatemia].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1967, Feb-06, Volume: 264, Issue:6

    Topics: Animals; Calcitonin; Calcium; Drug Antagonism; Drug Synergism; Hydroxyproline; Hypocalcemia; Male; P

1967
Role of the thyroid gland in magnesium-induced hypocalcemia in the bovine.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1971, Volume: 3, Issue:1

    Topics: Animals; Blood; Calcium; Cattle; Chlorides; Depression, Chemical; Female; Hypocalcemia; Magnesium; M

1971
Pathogenesis of hypocalcemia in magnesium depletion. Normal end-organ responsiveness to parathyroid hormone.
    The Journal of clinical investigation, 1971, Volume: 50, Issue:12

    Topics: Alkaline Phosphatase; Animals; Blood Proteins; Calcium; Diet; Dogs; Fasting; Female; Hypocalcemia; I

1971
[Metabolism of glucides in myocardium (II). B. Physiological and pathological variations].
    La Presse medicale, 1970, Feb-25, Volume: 78, Issue:10

    Topics: Animals; Cardiac Glycosides; Catecholamines; Glucagon; Glucose; Glycogen; Glycolysis; Guinea Pigs; H

1970
Evidence for the secretion of thyrocalcitonin at normal and subnormal plasma calcium levels.
    Endocrinology, 1968, Volume: 82, Issue:1

    Topics: Animals; Calcitonin; Calcium; Calcium Isotopes; Homeostasis; Hypocalcemia; Male; Parathyroid Glands;

1968
Normocalcaemia in relation to cortisone secretion.
    Nature, 1968, Mar-30, Volume: 217, Issue:5135

    Topics: Adrenalectomy; Animals; Calcium; Cortisone; Desoxycorticosterone; Dogs; Hydrogen-Ion Concentration;

1968
[Effect of calcitonin and thyroxine on calcium and phosphorus metabolism. Experimental study].
    Vnitrni lekarstvi, 1968, Volume: 14, Issue:12

    Topics: Animals; Calcitonin; Calcium; Female; Hyperthyroidism; Hypocalcemia; Phosphorus; Rats; Thyroxine

1968