Page last updated: 2024-11-06

thyroxine and Hyperemesis Gravidarum

thyroxine has been researched along with Hyperemesis Gravidarum in 34 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Hyperemesis Gravidarum: Intractable VOMITING that develops in early PREGNANCY and persists. This can lead to DEHYDRATION and WEIGHT LOSS.

Research Excerpts

ExcerptRelevanceReference
"We aimed to investigate cholecystokinin (CCK) release in pregnant women with and without hyperemesis gravidarum (HG)."7.81Disturbed release of cholecystokinin in pregnant women with hyperemesis gravidarum. ( Biberoglu, E; Biberoglu, K; Daglar, H; Demirtas, C; Dirican, A; Doganay, B; Iskender, C; Kirbas, A; Uygur, D, 2015)
"This study was set up to investigate the relationship between immune process and high levels of human chorionic gonadotropin-beta (betahCG) in hyperemesis patients with or without hyperthyroxinemia."7.70Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. ( Dokmetas, S; Erselcan, T; Leylek, OA; Toyaksi, M, 1999)
"We aimed to investigate cholecystokinin (CCK) release in pregnant women with and without hyperemesis gravidarum (HG)."3.81Disturbed release of cholecystokinin in pregnant women with hyperemesis gravidarum. ( Biberoglu, E; Biberoglu, K; Daglar, H; Demirtas, C; Dirican, A; Doganay, B; Iskender, C; Kirbas, A; Uygur, D, 2015)
" The decrease occurred despite a measurable increase of free thyroxine compared with normal pregnancy."3.72Basal metabolic rate in hyperemesis gravidarum: comparison to normal pregnancy and response to treatment. ( Araki, T; Chihara, H; Otsubo, Y; Power, GG; Sawa, R; Suzuki, S; Yoneyama, Y, 2003)
"This study was set up to investigate the relationship between immune process and high levels of human chorionic gonadotropin-beta (betahCG) in hyperemesis patients with or without hyperthyroxinemia."3.70Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. ( Dokmetas, S; Erselcan, T; Leylek, OA; Toyaksi, M, 1999)
"Forty-four patients (66%) had biochemical hyperthyroidism (increased free thyroxine index [n = 39] or suppressed thyroid-stimulating hormone [n = 40]) that was self-limited, resolving by 18 weeks' gestation."3.68Transient hyperthyroidism and hyperemesis gravidarum: clinical aspects. ( Goodwin, TM; Mestman, JH; Montoro, M, 1992)
"Plasma total T4 (TT4), T3 (TT3), free T4 (FT4), free T3 (FT3), thyroxine binding globulin, hCG, and erythrocyte zinc content were measured in 43 women with uncomplicated pregnancy and in 71 patients admitted with hyperemesis gravidarum."3.67Thyroid function in hyperemesis gravidarum. ( Chin, RK; Cockram, CS; Lao, TT; Mak, YT; Panesar, NS; Swaminathan, R, 1989)
"Plasma total thyroxine (TT4) and free thyroxine (FT4) were measured in 23 women with hyperemesis gravidarum at presentation, on average at about 10 weeks, in the second trimester, and before delivery."3.67Thyroxine concentration and outcome of hyperemetic pregnancies. ( Chin, RK; Lao, TT, 1988)
"Thyroid function in early normal pregnancy was evaluated with reference to morning sickness using a newly developed free thyroxine (T4) radioimmunoassay and a highly sensitive TSH immunoradiometric assay."3.67Morning sickness and thyroid function in normal pregnancy. ( Amino, N; Miyai, K; Mori, M; Tamaki, H; Tanizawa, O, 1988)
" Euthyroid hyperthyroxinemia may occur: as a response to abnormal plasma binding (thyroxine binding globulin, albumin, prealbumin, or autoantibodies), because of hormone resistance, after exposure to drugs such as amiodarone, cholecystographic contrast agents, or propranolol, during acute psychiatric illness or stress, and in hyperemesis gravidarum."3.67The diagnostic challenge of euthyroid hyperthyroxinemia. ( Barlow, JW; Stockigt, JR, 1985)
"An increased free thyroxine (T4) index was observed in 73% of 33 consecutive pregnancies complicated by severe hyperemesis gravidarum."3.66Thyroid function in patients with hyperemesis gravidarum. ( Bouillon, R; De Keyser, L; De Moor, P; De Roo, M; De Vos, P; Naesens, M; Renaer, M; Van Assche, FA, 1982)
"Thyroid diseases are common in women of childbearing age and it is well known that untreated thyroid disturbances result in an increased rate of adverse events, particularly miscarriage, preterm birth and gestational hypertension."2.47Thyroid disease in pregnancy. ( Mestman, JH; Negro, R, 2011)
"Clinical thyrotoxicosis is caused by circulating hCG with higher biological activity in pregnant women with hyperemesis."1.29Gestational thyrotoxicosis and hyperemesis gravidarum: possible role of hCG with higher stimulating activity. ( Amino, N; Ito, E; Kimura, M; Mitsuda, N; Miyai, K; Tamaki, H; Tanizawa, O, 1993)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19908 (23.53)18.7374
1990's7 (20.59)18.2507
2000's12 (35.29)29.6817
2010's5 (14.71)24.3611
2020's2 (5.88)2.80

Authors

AuthorsStudies
Iijima, S1
Nijsten, K1
Koot, MH1
van der Post, JAM1
Bais, JMJ1
Ris-Stalpers, C1
Naaktgeboren, C1
Bremer, HA1
van der Ham, DP1
Heidema, WM1
Huisjes, A1
Kleiverda, G1
Kuppens, SM1
van Laar, JOEH1
Langenveld, J1
van der Made, F1
Papatsonis, D1
Pelinck, MJ1
Pernet, PJ1
van Rheenen-Flach, L1
Rijnders, RJ1
Scheepers, HCJ1
Siegelaar, SE1
Vogelvang, T1
Mol, BW1
Roseboom, TJ1
Grooten, IJ1
Painter, RC1
Biberoglu, E1
Kirbas, A1
Iskender, C1
Dirican, A1
Daglar, H1
Demirtas, C1
Doganay, B1
Uygur, D1
Biberoglu, K1
Kuryłowicz, A1
Niewiński, G1
Kański, A1
Derlatka, P1
Czajkowski, K1
Bednarczuk, T1
Ambroziak, U1
Lockwood, CM1
Grenache, DG1
Gronowski, AM1
Ndungu, JR1
Amayo, A1
Qureshi, ZP1
Kigondu, CS1
Luetic, AT1
Miskovic, B1
Derbent, AU1
Yanik, FF1
Simavli, S1
Atasoy, L1
Urün, E1
Kuşçu, UE1
Turhan, NÖ1
Negro, R1
Mestman, JH2
Tan, JY1
Loh, KC1
Yeo, GS1
Chee, YC1
Al-Yatama, M1
Diejomaoh, M1
Nandakumaran, M1
Monem, RA1
Omu, AE1
Al Kandari, F1
Chihara, H1
Otsubo, Y1
Yoneyama, Y1
Sawa, R1
Suzuki, S1
Power, GG2
Araki, T3
Asakura, H2
Nakai, A1
Kuscu, NK1
Yildirim, Y1
Koyuncu, F1
Var, A1
Uyanik, BS1
Navaneethakrishnan, R1
Lindow, SW1
Masson, EA1
Allan, B1
Makowska, B1
Preis, K1
Swiatkowska-Freund, M1
Leszczyńska, K1
Juras, N1
Banovac, K1
Sekso, M1
Bouillon, R1
Naesens, M1
Van Assche, FA1
De Keyser, L1
De Moor, P1
Renaer, M1
De Vos, P1
De Roo, M1
Tsuruta, E1
Tada, H1
Tamaki, H3
Kashiwai, T1
Asahi, K1
Takeoka, K1
Mitsuda, N2
Amino, N3
Lazarus, JH1
Kimura, M1
Ito, E1
Miyai, K2
Tanizawa, O2
Tareen, AK1
Baseer, A1
Jaffry, HF1
Shafiq, M1
Leylek, OA1
Toyaksi, M1
Erselcan, T1
Dokmetas, S1
Watanabe, S1
Sekiguchi, A1
Girling, JC1
Hiroi, H1
Kugu, K1
Hoshino, H1
Kozuma, S1
Taketani, Y1
Wilson, R1
McKillop, JH1
MacLean, M1
Walker, JJ1
Fraser, WD1
Gray, C1
Dryburgh, F1
Thomson, JA1
Goodwin, TM1
Montoro, M1
Swaminathan, R1
Chin, RK3
Lao, TT3
Mak, YT2
Panesar, NS2
Cockram, CS1
Bober, SA1
McGill, AC1
Tunbridge, WM1
Mori, M1
Stockigt, JR1
Barlow, JW1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Controlled Trial of Day Care Versus Inpatient Management of Nausea and Vomiting of Pregnancy[NCT00795561]98 participants (Actual)Interventional2009-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for thyroxine and Hyperemesis Gravidarum

ArticleYear
Pitfalls in the assessment of gestational transient thyrotoxicosis.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2020, Volume: 36, Issue:8

    Topics: Diagnosis, Differential; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Complications;

2020
Thyroid disease in pregnancy.
    Best practice & research. Clinical endocrinology & metabolism, 2011, Volume: 25, Issue:6

    Topics: Abnormalities, Drug-Induced; Antithyroid Agents; Autoimmunity; Female; Humans; Hyperemesis Gravidaru

2011
Thyroid disease in pregnancy.
    Hospital medicine (London, England : 1998), 2000, Volume: 61, Issue:12

    Topics: Antithyroid Agents; Diagnosis, Differential; Embryonic and Fetal Development; Female; Humans; Hypere

2000

Other Studies

31 other studies available for thyroxine and Hyperemesis Gravidarum

ArticleYear
Thyroid-stimulating hormone and free thyroxine fail to predict the severity and clinical course of hyperemesis gravidarum: A prospective cohort study.
    Acta obstetricia et gynecologica Scandinavica, 2021, Volume: 100, Issue:8

    Topics: Adult; Biomarkers; Cohort Studies; Female; Humans; Hyperemesis Gravidarum; Predictive Value of Tests

2021
Disturbed release of cholecystokinin in pregnant women with hyperemesis gravidarum.
    The journal of obstetrics and gynaecology research, 2015, Volume: 41, Issue:4

    Topics: Adolescent; Adult; Case-Control Studies; Cholecystokinin; Female; Humans; Hyperemesis Gravidarum; Ni

2015
Severe gestational hyperthyroidism complicated by cardiac arrest - a case report.
    Ginekologia polska, 2017, Volume: 88, Issue:1

    Topics: Abortion, Therapeutic; Adult; Antithyroid Agents; Cardiopulmonary Resuscitation; Female; Heart Arres

2017
Serum human chorionic gonadotropin concentrations greater than 400,000 IU/L are invariably associated with suppressed serum thyrotropin concentrations.
    Thyroid : official journal of the American Thyroid Association, 2009, Volume: 19, Issue:8

    Topics: Chorionic Gonadotropin; Cohort Studies; Female; Gestational Age; Gestational Trophoblastic Disease;

2009
Gestational thyrotoxicosis associated with emesis in early pregnancy.
    East African medical journal, 2009, Volume: 86, Issue:2

    Topics: Adolescent; Adult; Chorionic Gonadotropin, beta Subunit, Human; Cross-Sectional Studies; Female; Hum

2009
Is hyperthyroidism underestimated in pregnancy and misdiagnosed as hyperemesis gravidarum?
    Medical hypotheses, 2010, Volume: 75, Issue:4

    Topics: Chorionic Gonadotropin; Croatia; Diagnosis, Differential; Female; Humans; Hyperemesis Gravidarum; Hy

2010
First trimester maternal serum PAPP-A and free β-HCG levels in hyperemesis gravidarum.
    Prenatal diagnosis, 2011, Volume: 31, Issue:5

    Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Chorionic Gonadotropin, beta Subunit, Huma

2011
Transient hyperthyroidism of hyperemesis gravidarum.
    BJOG : an international journal of obstetrics and gynaecology, 2002, Volume: 109, Issue:6

    Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Birth Weight; Female; Humans; Hyperemesis

2002
Hormone profile of Kuwaiti women with hyperemesis gravidarum.
    Archives of gynecology and obstetrics, 2002, Volume: 266, Issue:4

    Topics: Adult; Case-Control Studies; Chorionic Gonadotropin, beta Subunit, Human; Female; Gestational Age; H

2002
Basal metabolic rate in hyperemesis gravidarum: comparison to normal pregnancy and response to treatment.
    American journal of obstetrics and gynecology, 2003, Volume: 188, Issue:2

    Topics: Basal Metabolism; Female; Humans; Hyperemesis Gravidarum; Oxygen Consumption; Pregnancy; Reference V

2003
Correlations between interscapular deep temperature and plasma free fatty acid levels in pregnant women with hyperemesis gravidarum.
    Archives of gynecology and obstetrics, 2003, Volume: 268, Issue:1

    Topics: Adipose Tissue, Brown; Blood Proteins; Body Temperature; Erythrocyte Count; Fatty Acids, Nonesterifi

2003
Interleukin-6 levels in hyperemesis gravidarum.
    Archives of gynecology and obstetrics, 2003, Volume: 269, Issue:1

    Topics: Adult; Chorionic Gonadotropin; Female; Humans; Hyperemesis Gravidarum; Interleukin-6; Pregnancy; Pre

2003
Recurrent gestational thyrotoxicosis presenting as recurrent hyperemesis gravidarum--report of two cases.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2004, Volume: 24, Issue:7

    Topics: Abortion, Spontaneous; Adult; Antithyroid Agents; Carbimazole; Female; Gestational Age; Heart Rate,

2004
[Assessment of thyroid function in women treated for vomiting in early pregnancy].
    Ginekologia polska, 2005, Volume: 76, Issue:8

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Female; Humans; Hyperemesis Gravidarum; Hyperthyroid

2005
Increased serum reverse triiodothyronine in patients with hyperemesis gravidarum.
    Acta endocrinologica, 1983, Volume: 102, Issue:2

    Topics: Adult; Female; Humans; Hyperemesis Gravidarum; Pituitary Gland; Pregnancy; Thyroid Gland; Thyrotropi

1983
Thyroid function in patients with hyperemesis gravidarum.
    American journal of obstetrics and gynecology, 1982, Aug-15, Volume: 143, Issue:8

    Topics: Abortion, Spontaneous; Adolescent; Adult; Birth Weight; Diagnosis, Differential; Female; Humans; Hyp

1982
Pathogenic role of asialo human chorionic gonadotropin in gestational thyrotoxicosis.
    The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:2

    Topics: Adult; Asialoglycoproteins; Chorionic Gonadotropin; Female; Humans; Hyperemesis Gravidarum; Pregnanc

1995
Pregnancy, hCG, thyrotoxicosis and hyperemesis gravidarum.
    Clinical endocrinology, 1993, Volume: 38, Issue:4

    Topics: Chorionic Gonadotropin; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Complications;

1993
Gestational thyrotoxicosis and hyperemesis gravidarum: possible role of hCG with higher stimulating activity.
    Clinical endocrinology, 1993, Volume: 38, Issue:4

    Topics: Chorionic Gonadotropin; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Thyroid Gland; Thyrotoxic

1993
Thyroid hormone in hyperemesis gravidarum.
    Journal of obstetrics and gynaecology (Tokyo, Japan), 1995, Volume: 21, Issue:5

    Topics: Chorionic Gonadotropin; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Thyroid Hormones; Thyrotr

1995
Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia.
    Gynecologic and obstetric investigation, 1999, Volume: 47, Issue:4

    Topics: Chorionic Gonadotropin, beta Subunit, Human; Complement C3; Complement C4; Female; Humans; Hyperemes

1999
Severity of hyperemesis gravidarum correlates with serum levels of reverse T3.
    Archives of gynecology and obstetrics, 2000, Volume: 264, Issue:2

    Topics: Fatty Acids, Nonesterified; Female; Gestational Age; Humans; Hyperemesis Gravidarum; Lipolysis; Preg

2000
Hyperemesis gravidarum associated with thyrotoxicosis and a past history of an eating disorder.
    Archives of gynecology and obstetrics, 2001, Volume: 265, Issue:4

    Topics: Adult; Anorexia Nervosa; Antithyroid Agents; Female; Fetal Growth Retardation; Gestational Age; Huma

2001
Thyroid function tests are rarely abnormal in patients with severe hyperemesis gravidarum.
    Clinical endocrinology, 1992, Volume: 37, Issue:4

    Topics: Antibodies; Autoantibodies; Chorionic Gonadotropin; Female; Humans; Hyperemesis Gravidarum; Immunogl

1992
Transient hyperthyroidism and hyperemesis gravidarum: clinical aspects.
    American journal of obstetrics and gynecology, 1992, Volume: 167, Issue:3

    Topics: Adolescent; Adult; Amylases; Electrolytes; Female; Humans; Hyperemesis Gravidarum; Hyperthyroidism;

1992
Thyroid function in hyperemesis gravidarum.
    Acta endocrinologica, 1989, Volume: 120, Issue:2

    Topics: Adult; Chorionic Gonadotropin; Erythrocytes; Female; Follow-Up Studies; Humans; Hyperemesis Gravidar

1989
Thyroid function in hyperemesis gravidarum.
    Acta endocrinologica, 1986, Volume: 111, Issue:3

    Topics: Female; Humans; Hyperemesis Gravidarum; Pituitary Gland; Pregnancy; Thyroid Gland; Thyrotropin; Thyr

1986
Plasma zinc concentration and thyroid function in hyperemetic pregnancies.
    Acta obstetricia et gynecologica Scandinavica, 1988, Volume: 67, Issue:7

    Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Thyroxine; Triiodothyronine; Zinc

1988
Thyroxine concentration and outcome of hyperemetic pregnancies.
    British journal of obstetrics and gynaecology, 1988, Volume: 95, Issue:5

    Topics: Birth Weight; Carbimazole; Female; Gestational Age; Humans; Hyperemesis Gravidarum; Infant, Newborn;

1988
Morning sickness and thyroid function in normal pregnancy.
    Obstetrics and gynecology, 1988, Volume: 72, Issue:3 Pt 1

    Topics: Analysis of Variance; Chorionic Gonadotropin; Female; Humans; Hyperemesis Gravidarum; Nausea; Pregna

1988
The diagnostic challenge of euthyroid hyperthyroxinemia.
    Australian and New Zealand journal of medicine, 1985, Volume: 15, Issue:2

    Topics: Amiodarone; Autoantibodies; Female; Humans; Hyperemesis Gravidarum; Male; Mental Disorders; Prealbum

1985