Page last updated: 2024-11-06

thyroxine and Hodgkin Disease

thyroxine has been researched along with Hodgkin Disease in 22 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.

Research Excerpts

ExcerptRelevanceReference
"In an attempt to reduce the incidence of hypothyroidism following irradiation of the neck, we administered oral L-thyroxine in doses sufficient to suppress serum TSH to 20 patients receiving radiation therapy for Hodgkin's disease or other lymphomas."5.05Thyroxine administration during radiation therapy to the neck does not prevent subsequent thyroid dysfunction. ( Bantle, JP; Lee, CK; Levitt, SH, 1985)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199015 (68.18)18.7374
1990's3 (13.64)18.2507
2000's1 (4.55)29.6817
2010's3 (13.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Peiró, I1
Palmero, R1
Iglesias, P1
Díez, JJ1
Simó-Servat, A1
Marín, JA1
Jiménez, L1
Domingo-Domenech, E1
Mancho-Fora, N1
Nadal, E1
Villabona, C1
Cella, L1
Conson, M1
Caterino, M1
De Rosa, N1
Liuzzi, R1
Picardi, M1
Grimaldi, F1
Solla, R1
Farella, A1
Salvatore, M1
Pacelli, R1
Massimino, M1
Gandola, L1
Pignoli, E1
Seregni, E1
Marchianò, A1
Pecori, E1
Catania, S1
Cefalo, G1
Metzger, ML1
Hudson, MM1
Somes, GW1
Shorr, RI1
Li, CS1
Krasin, MJ1
Shelso, J1
Pui, CH1
Howard, SC1
Pekić, B2
Popović, M1
Pavelić, K2
Gabrilovac, J1
Bratic-Mikes, V1
Boranic, M1
Shiriaev, SV1
Zubovskiĭ, LG1
Poliakov, VE1
Holt, G1
Galligan, J1
Winship, J1
Roeser, P1
Mortimer, R1
Constine, LS1
Donaldson, SS1
McDougall, IR2
Cox, RS1
Link, MP1
Kaplan, HS1
Devney, RB1
Sklar, CA1
Nesbit, ME1
Kim, TH1
Williamson, JF1
Robison, LL1
Ramsay, NK1
Simbirtseva, LP1
Iulbarisov, AV1
Lapchenkov, VI1
Borisova, LIa1
Schimpff, SC1
Diggs, CH1
Wiswell, JG1
Salvatore, PC1
Wiernik, PH1
Bayer, MF1
Shafford, EA1
Kingston, JE1
Healy, JC1
Webb, JA1
Plowman, PN1
Reznek, RH1
Serrano, JC1
Contreras, K1
Insausti, L1
Figueroa, L1
Acquatella, G1
Worm, AM2
Brinckmeyer, LM2
Nissen, NI2
Peerboom, PF1
Hassink, EA1
Melkert, R1
DeWit, L1
Nooijen, WJ1
Bruning, PF1
Morgan, GW1
Freeman, AP1
McLean, RG1
Jarvie, BH1
Giles, RW1
Bantle, JP1
Lee, CK1
Levitt, SH1
Glatstein, E1
McHardy-Young, S1
Brast, N1
Eltringham, JR1
Kriss, JP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Protection From Iatrogenic Hypothyroidism Patients With MBL and Pediatric Patients With HL and Non-HL Needing Radiotherapy on Thyroid Site[NCT05316922]Phase 368 participants (Anticipated)Interventional2021-12-13Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for thyroxine and Hodgkin Disease

ArticleYear
Thyroxine administration during radiation therapy to the neck does not prevent subsequent thyroid dysfunction.
    International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:11

    Topics: Adolescent; Adult; Female; Hodgkin Disease; Humans; Hypothyroidism; Lymphoma; Male; Middle Aged; Nec

1985

Other Studies

21 other studies available for thyroxine and Hodgkin Disease

ArticleYear
Thyroid dysfunction induced by nivolumab: searching for disease patterns and outcomes.
    Endocrine, 2019, Volume: 64, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Immunological; Carcinoma, Non-Small-Cell Lung; Female; Hodgkin D

2019
Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma.
    International journal of radiation oncology, biology, physics, 2012, Apr-01, Volume: 82, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Female;

2012
TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma.
    Pediatric blood & cancer, 2011, Jul-15, Volume: 57, Issue:1

    Topics: Adolescent; Child; Disease-Free Survival; Female; Hodgkin Disease; Humans; Hypothyroidism; Male; Rad

2011
White race as a risk factor for hypothyroidism after treatment for pediatric Hodgkin's lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Apr-01, Volume: 24, Issue:10

    Topics: Adolescent; Adult; Black People; Child; Child, Preschool; Female; Hodgkin Disease; Hormone Replaceme

2006
[Changes in hormone concentrations in the blood of patients with malignant diseases of the blood].
    Srpski arhiv za celokupno lekarstvo, 1984, Volume: 112, Issue:5

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Growth Hormone; Hodgkin Disease; Hormones; Humans; Hydroco

1984
Hormonal changes in patients with haematological malignancies.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1981, Volume: 35, Issue:6

    Topics: Acute Disease; Adrenocorticotropic Hormone; Adult; Aged; Chronic Disease; Female; Growth Hormone; Ho

1981
[Hormones and ferritin in children with lymphogranulomatosis].
    Meditsinskaia radiologiia, 1982, Volume: 27, Issue:8

    Topics: Adrenocorticotropic Hormone; Child; Ferritins; Hodgkin Disease; Humans; Hydrocortisone; Insulin; Thy

1982
Serum thyroglobulin after mantle irradiation for Hodgkin's disease.
    Clinical endocrinology, 1983, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Aged; Child; Female; Hodgkin Disease; Humans; Male; Middle Aged; Thyroglobulin; T

1983
Thyroid dysfunction after radiotherapy in children with Hodgkin's disease.
    Cancer, 1984, Feb-15, Volume: 53, Issue:4

    Topics: Adolescent; Age Factors; Child; Child, Preschool; Combined Modality Therapy; Dose-Response Relations

1984
Serial thyroid function measurements in children with Hodgkin disease.
    The Journal of pediatrics, 1984, Volume: 105, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modali

1984
[Radioimmunological determination of thyrotropic hormone, triiodothyronine and thyroxine in lymphogranulomatosis during radiation and combined therapy].
    Meditsinskaia radiologiia, 1983, Volume: 28, Issue:4

    Topics: Adolescent; Adult; Hodgkin Disease; Humans; Middle Aged; Neoplasm Staging; Radioimmunoassay; Thyrotr

1983
Radiation-related thyroid dysfunction: implications for the treatment of Hodgkin's disease.
    Annals of internal medicine, 1980, Volume: 92, Issue:1

    Topics: Adolescent; Adult; Child; Drug-Related Side Effects and Adverse Reactions; Follow-Up Studies; Head a

1980
Radioimmunoassay of free thyroxine in serum: comparison with clinical findings and results of conventional thyroid-function tests.
    Clinical chemistry, 1980, Volume: 26, Issue:8

    Topics: Hodgkin Disease; Humans; Hyperthyroidism; Hypothyroidism; Radioimmunoassay; Reference Values; Thyroi

1980
Thyroid nodular disease after radiotherapy to the neck for childhood Hodgkin's disease.
    British journal of cancer, 1999, Volume: 80, Issue:5-6

    Topics: Adolescent; Biopsy, Needle; Child; Child, Preschool; Dose-Response Relationship, Radiation; Female;

1999
[Thyroid complications in Hodgkin's disease patients treated with radiotherapy and chemotherapy].
    Sangre, 1999, Volume: 44, Issue:6

    Topics: Adolescent; Adult; Child; Child, Preschool; Female; Hodgkin Disease; Humans; Male; Thyroid Diseases;

1999
[Thyroid function in malignant lymphoma].
    Ugeskrift for laeger, 1977, Sep-05, Volume: 139, Issue:36

    Topics: Adult; Aged; Female; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, N

1977
Thyroid function in malignant lymphoma.
    Acta medica Scandinavica, 1977, Volume: 202, Issue:6

    Topics: Adolescent; Adult; Aged; Female; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse;

1977
Thyroid function 10-18 years after mantle field irradiation for Hodgkin's disease.
    European journal of cancer (Oxford, England : 1990), 1992, Volume: 28A, Issue:10

    Topics: Adult; Age Factors; Aged; Female; Follow-Up Studies; Hodgkin Disease; Humans; Hypothyroidism; Male;

1992
Late cardiac, thyroid, and pulmonary sequelae of mantle radiotherapy for Hodgkin's disease.
    International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:11

    Topics: Adult; Carbon Monoxide; Electrocardiography; Forced Expiratory Volume; Heart; Hodgkin Disease; Human

1985
Alterations in serum thyrotropin (TSH) and thyroid function following radiotherapy in patients with malignant lymphoma.
    The Journal of clinical endocrinology and metabolism, 1971, Volume: 32, Issue:6

    Topics: Adolescent; Adult; Female; Head and Neck Neoplasms; Hodgkin Disease; Humans; Hypothyroidism; Ion Exc

1971
[Diseases of the thyroid gland].
    Medizinische Klinik, 1967, May-19, Volume: 62, Issue:20

    Topics: Daunorubicin; Goiter; Graves Disease; Hematologic Diseases; Hodgkin Disease; Humans; Hyperthyroidism

1967