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thyroxine and Hepatic Encephalopathy

thyroxine has been researched along with Hepatic Encephalopathy in 16 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"Recent data from animal studies suggest that induced hypothyroidism prevents the hyperdynamic circulation in portal vein ligated rats, liver cirrhosis in rats chronically treated with thioacetamide (TAA), and immune-mediated acute liver injury induced in mice by concanavalin A."7.70Hypothyroidism minimizes liver damage and improves survival in rats with thioacetamide induced fulminant hepatic failure. ( Aeed, H; Avni, Y; Bruck, R; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1998)
"Grades 3 to 4 hepatic encephalopathy (advanced HE), also termed brain failure, is an organ failure that defines acute-on-chronic liver failure."5.91Admission Serum Metabolites and Thyroxine Predict Advanced Hepatic Encephalopathy in a Multicenter Inpatient Cirrhosis Cohort. ( Bajaj, JS; Fagan, A; Garcia-Tsao, G; Kamath, PS; Lai, JC; McGeorge, S; O'Leary, JG; Reddy, KR; Subramanian, RM; Tandon, P; Thacker, LR; Thuluvath, P; Vargas, HE; Wong, F, 2023)
"15 consecutive patients with hepatic encephalopathy secondary to non-alcoholic cirrhosis (8 males and 7 females, age 37-75 years) and 33 non-alcoholic cirrhotic patients without encephalopathy (22 males and 11 females, age 36-74 years) were investigated."5.32Low serum total thyroxine and free triiodothyronine in patients with hepatic encephalopathy due to non-alcoholic cirrhosis. ( Kaya, A; Kayacetin, E; Kisakol, G, 2003)
"Recent data from animal studies suggest that induced hypothyroidism prevents the hyperdynamic circulation in portal vein ligated rats, liver cirrhosis in rats chronically treated with thioacetamide (TAA), and immune-mediated acute liver injury induced in mice by concanavalin A."3.70Hypothyroidism minimizes liver damage and improves survival in rats with thioacetamide induced fulminant hepatic failure. ( Aeed, H; Avni, Y; Bruck, R; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1998)
" On the diagnosis of hypothalamic hypothyroidism, she was treated with levothyroxine sodium."3.68Portal-systemic encephalopathy and hypothalamic hypothyroidism: effect of thyroid hormone on ammonia metabolism. ( Hitoshi, S; Sakuta, M; Terao, Y, 1993)
"To evaluate thyroid function in 19 patients with fulminant hepatitis (FH), we have measured total and free 3,5,3'-triiodothyronine (T3) and thyroxine (T4), 3,3',5'-triiodothyronine (reverse T3, rT3), thyroid-stimulating hormone (TSH) and thyroxin-binding globulin (TBG) in patients with FH, compared with those of 80 patients with other various liver diseases and of 10 healthy controls."3.67Serum thyroid hormone levels in patients with fulminant hepatitis: usefulness of rT3 and the rT3/T3 ratio as prognostic indices. ( Kano, T; Kojima, T; Muto, Y; Takahashi, T, 1987)
" Twenty patients suffering from severe non-endocrine diseases (septicaemia, fulminant hepatic and renal failure, acute pancreatitis, polytrauma, cerebral haemorrhage) were found to have serum thyroxine levels in the hypothyroid range (less than 4 micrograms/dl)."3.66Pituitary-thyroid dysfunction in severe non-thyroidal disease: "low-T4 syndrome". ( Bratusch-Marrain, P; Grubeck-Loebenstein, B; Kleinberger, G; Vierhapper, H; Waldhäusl, W, 1982)
"Despite aggressive treatment of hepatic encephalopathy, there was no clinical improvement."2.41Primary hypothyroidism masquerading as hepatic encephalopathy: case report and review of the literature. ( Jones, MP; Pilger, P; Thobe, N, 2000)
"Grades 3 to 4 hepatic encephalopathy (advanced HE), also termed brain failure, is an organ failure that defines acute-on-chronic liver failure."1.91Admission Serum Metabolites and Thyroxine Predict Advanced Hepatic Encephalopathy in a Multicenter Inpatient Cirrhosis Cohort. ( Bajaj, JS; Fagan, A; Garcia-Tsao, G; Kamath, PS; Lai, JC; McGeorge, S; O'Leary, JG; Reddy, KR; Subramanian, RM; Tandon, P; Thacker, LR; Thuluvath, P; Vargas, HE; Wong, F, 2023)
"15 consecutive patients with hepatic encephalopathy secondary to non-alcoholic cirrhosis (8 males and 7 females, age 37-75 years) and 33 non-alcoholic cirrhotic patients without encephalopathy (22 males and 11 females, age 36-74 years) were investigated."1.32Low serum total thyroxine and free triiodothyronine in patients with hepatic encephalopathy due to non-alcoholic cirrhosis. ( Kaya, A; Kayacetin, E; Kisakol, G, 2003)
"Patients with hepatic encephalopathy due to non-alcoholic cirrhosis were studied at Erciyes University Hospital, Kayseri, Turkey, between August 1990 and October 1991."1.29Thyroid function tests in non-alcoholic cirrhotic patients with hepatic encephalopathy. ( Güven, K; Kelestimur, F; Yücesoy, M, 1993)
"Similarly, the presence or absence of hepatic encephalopathy determined, and/or reflected, at least in part, the type of response observed."1.27Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease. ( Gavaler, JS; Sanghvi, A; Schade, RR; Tarter, R; Van Thiel, DH, 1986)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19907 (43.75)18.7374
1990's4 (25.00)18.2507
2000's2 (12.50)29.6817
2010's2 (12.50)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Bajaj, JS1
Tandon, P1
O'Leary, JG1
Reddy, KR1
Garcia-Tsao, G1
Thuluvath, P1
Lai, JC1
Subramanian, RM1
Vargas, HE1
Wong, F1
Fagan, A1
McGeorge, S1
Thacker, LR1
Kamath, PS1
Díaz-Fontenla, F1
Castillo-Pradillo, M1
Díaz-Gómez, A1
Ibañez-Samaniego, L1
Gancedo, P1
Guzmán-de-Villoria, JA1
Fernández-García, P1
Bañares-Cañizares, R1
García-Martínez, R1
Redkar, N1
Bendle, M1
Maidapwad, V1
Chavan, R1
Shriwastav, R1
Kayacetin, E1
Kisakol, G1
Kaya, A1
Rink, C1
Siersleben, U1
Haerting, J1
Klaua, M1
Mertens, E1
Bratusch-Marrain, P1
Vierhapper, H1
Grubeck-Loebenstein, B1
Waldhäusl, W1
Kleinberger, G1
Güven, K1
Kelestimur, F1
Yücesoy, M1
Hitoshi, S1
Terao, Y1
Sakuta, M1
Bruck, R1
Oren, R1
Shirin, H1
Aeed, H1
Papa, M1
Matas, Z1
Zaidel, L1
Avni, Y1
Halpern, Z1
Caregaro, L1
Alberino, F1
Amodio, P1
Merkel, C1
Angeli, P1
Plebani, M1
Gatta, A1
Thobe, N1
Pilger, P1
Jones, MP1
Schlienger, JL1
Hasselmann, M1
Imler, M1
Biersack, HJ1
Raabe, W1
Rommelsheim, K1
Rohner, HG1
Fuchs, HJ1
Winkler, C1
Van Thiel, DH1
Tarter, R1
Gavaler, JS1
Schade, RR1
Sanghvi, A1
Kano, T1
Kojima, T1
Takahashi, T1
Muto, Y1
Bregengård, C1
Kirkegaard, C1
Faber, J1
Poulsen, S1
Siersbaek-Nielsen, K1
Friis, T1

Reviews

1 review available for thyroxine and Hepatic Encephalopathy

ArticleYear
Primary hypothyroidism masquerading as hepatic encephalopathy: case report and review of the literature.
    Postgraduate medical journal, 2000, Volume: 76, Issue:897

    Topics: Aged; Diagnosis, Differential; Female; Hepatic Encephalopathy; Hepatitis C, Chronic; Humans; Hypothy

2000

Other Studies

15 other studies available for thyroxine and Hepatic Encephalopathy

ArticleYear
Admission Serum Metabolites and Thyroxine Predict Advanced Hepatic Encephalopathy in a Multicenter Inpatient Cirrhosis Cohort.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2023, Volume: 21, Issue:4

    Topics: Fibrosis; Hepatic Encephalopathy; Humans; Inpatients; Liver Cirrhosis; Prospective Studies; Thyroxin

2023
Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism.
    World journal of gastroenterology, 2017, Jul-28, Volume: 23, Issue:28

    Topics: Adrenergic beta-Antagonists; Alcoholism; Ammonia; Antithyroid Agents; Brain; Carbimazole; Diagnosis,

2017
Hepatic encephalopathy masking myxedema coma.
    The Journal of the Association of Physicians of India, 2012, Volume: 60

    Topics: Aged; Coma; Diagnosis, Differential; Glasgow Coma Scale; Hepatic Encephalopathy; Humans; Hydrocortis

2012
Low serum total thyroxine and free triiodothyronine in patients with hepatic encephalopathy due to non-alcoholic cirrhosis.
    Swiss medical weekly, 2003, Apr-05, Volume: 133, Issue:13-14

    Topics: Adult; Aged; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Middle Aged; Prothrombin

2003
[The T3 syndrome in patients with liver cirrhosis].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1982, Aug-15, Volume: 37, Issue:16

    Topics: Collateral Circulation; Hepatic Encephalopathy; Humans; Liver Circulation; Liver Cirrhosis; Radioimm

1982
Pituitary-thyroid dysfunction in severe non-thyroidal disease: "low-T4 syndrome".
    Endokrinologie, 1982, Volume: 80, Issue:2

    Topics: Acute Disease; Acute Kidney Injury; Adolescent; Adult; Aged; Critical Care; Female; Hepatic Encephal

1982
Thyroid function tests in non-alcoholic cirrhotic patients with hepatic encephalopathy.
    The European journal of medicine, 1993, Volume: 2, Issue:2

    Topics: Adult; Aged; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Middle Aged; Prognosis;

1993
Portal-systemic encephalopathy and hypothalamic hypothyroidism: effect of thyroid hormone on ammonia metabolism.
    Internal medicine (Tokyo, Japan), 1993, Volume: 32, Issue:8

    Topics: Ammonia; Euthyroid Sick Syndromes; Female; Hepatic Encephalopathy; Humans; Hypothalamic Diseases; Hy

1993
Hypothyroidism minimizes liver damage and improves survival in rats with thioacetamide induced fulminant hepatic failure.
    Hepatology (Baltimore, Md.), 1998, Volume: 27, Issue:4

    Topics: Ammonia; Animals; Cytokines; Hepatic Encephalopathy; Hypothyroidism; Liver; Male; Malondialdehyde; R

1998
Nutritional and prognostic significance of serum hypothyroxinemia in hospitalized patients with liver cirrhosis.
    Journal of hepatology, 1998, Volume: 28, Issue:1

    Topics: Adult; Aged; Ascites; Blood Proteins; Female; Hepatic Encephalopathy; Hepatitis, Viral, Human; Human

1998
Possible role of hyperammonaemia and/or of portosystemic shunts on the variability of the TSH response to TRH in cirrhotic patients.
    Acta endocrinologica, 1978, Volume: 89, Issue:2

    Topics: Adult; Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Function Tests;

1978
[Thyroid hormones and thyrotropin in liver and kidney insufficiency].
    Nuklearmedizin. Nuclear medicine, 1976, Volume: 15, Issue:3

    Topics: Hepatic Encephalopathy; Humans; Kidney Failure, Chronic; Liver; Thyroid Hormones; Thyrotropin; Thyro

1976
Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease.
    Journal of endocrinological investigation, 1986, Volume: 9, Issue:6

    Topics: Carcinoma, Hepatocellular; Growth Hormone; Hepatic Encephalopathy; Humans; Liver Diseases; Liver Neo

1986
Serum thyroid hormone levels in patients with fulminant hepatitis: usefulness of rT3 and the rT3/T3 ratio as prognostic indices.
    Gastroenterologia Japonica, 1987, Volume: 22, Issue:3

    Topics: Adult; Aged; Female; Hepatic Encephalopathy; Hepatitis; Humans; Male; Methionine; Middle Aged; Progn

1987
The influence of free fatty acids on the free fraction of thyroid hormones in serum as estimated by ultrafiltration.
    Acta endocrinologica, 1987, Volume: 116, Issue:1

    Topics: Cerebrovascular Disorders; Fatty Acids, Nonesterified; Hepatic Encephalopathy; Humans; Kidney Failur

1987