Page last updated: 2024-11-06

thyroxine and Graves Ophthalmopathy

thyroxine has been researched along with Graves Ophthalmopathy in 52 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Graves Ophthalmopathy: An autoimmune disorder of the EYE, occurring in patients with Graves disease. Subtypes include congestive (inflammation of the orbital connective tissue), myopathic (swelling and dysfunction of the extraocular muscles), and mixed congestive-myopathic ophthalmopathy.

Research Excerpts

ExcerptRelevanceReference
"MP group than the TG group experienced adverse events."7.01Efficacy and safety of tripterygium glycosides for active moderate to severe Graves' ophthalmopathy: a randomised, observer-masked, single-centre trial. ( Liu, J; Lu, B; Shao, J; Wang, J; Ye, X; Zhao, H, 2021)
"Graves' disease is the most common cause of hyperthyroidism."6.66Effect of Addition of Thyroxine in the Treatment of Graves' Disease: A Systematic Review. ( Bai, L; Li, J; Wei, F; Wei, J; Wei, M; Xiao, Y; Yan, W, 2020)
"Euthyroidism was defined as both serum thyrotropin (thyroid-stimulating hormone [TSH]) and free thyroxine (FT4) within their reference ranges or, when only one was available, it was within its reference range; hypothyroidism as TSH ≥ 10 mU/L, or subnormal FT4 regardless of TSH; hyperthyroidism as TSH below and FT4 above their reference ranges; dysthyroidism as the sum of hypo- and hyperthyroidism; subclinical hypothyroidism as normal FT4 and TSH between the upper limit of normal and <10 mU/L; and subclinical hyperthyroidism as low TSH and normal FT4."4.12Postradioiodine Graves' management: The PRAGMA study. ( Abraham, P; Atkin, SL; Basu, A; Bennett, S; Boelaert, K; Crown, A; Dayan, C; Drake, WM; Falinska, A; Gibb, FW; Gilbert, J; Gleeson, H; Grossman, A; Hickey, J; Jarvis, S; Johnson, A; Johnston, C; Jones, TH; Karavitaki, N; Lazarus, JH; Leese, GP; Levy, MJ; Madathil, A; Malik, I; Mishra, B; Moran, C; Nag, S; Orme, SM; Pariani, N; Perros, P; Plummer, Z; Ray, DW; Razvi, S; Rees, A; Sanderson, V; Sathyapalan, T; Sturrock, N; Syed, AA; Vaidya, B; Velusamy, A; Williams, GR; Žarković, MP, 2022)
"The novel peptides markedly reduced thyroid size, serum thyroxine levels, retro-orbital fibrosis, and tachycardia in Ad-TSHR289-immunized mice."3.91Therapeutic Effects of Short Cyclic and Combined Epitope Peptides in a Long-Term Model of Graves' Disease and Orbitopathy. ( Faßbender, J; Holthoff, HP; Li, Z; Ungerer, M, 2019)
"0 mL, but we observed severe hyperthyroidism with elevated serum free triiodothyronine, free thyroxine, and thyrotropin receptor antibody levels."3.78Severe Graves' ophthalmopathy after percutaneous ethanol injection in a nontoxic thyroid nodule. ( Le Moli, R; Muscia, V; Pezzino, V; Regalbuto, C; Russo, M; Vigneri, R, 2012)
"MP group than the TG group experienced adverse events."3.01Efficacy and safety of tripterygium glycosides for active moderate to severe Graves' ophthalmopathy: a randomised, observer-masked, single-centre trial. ( Liu, J; Lu, B; Shao, J; Wang, J; Ye, X; Zhao, H, 2021)
"To compare the therapeutic effect and side effect of the treatments on hyperthyroid exophthalmos with the combination of acupuncture and medication and with medication only."2.75[Therapeutic effect and side effect of treatment on hyperthyroid exophthalmos with the combination of acupuncture and medication]. ( He, JS; Li, Y; Liu, SM; Shu, S; Xia, Y, 2010)
"Graves' disease is the most common cause of hyperthyroidism."2.66Effect of Addition of Thyroxine in the Treatment of Graves' Disease: A Systematic Review. ( Bai, L; Li, J; Wei, F; Wei, J; Wei, M; Xiao, Y; Yan, W, 2020)
"Autoimmune reactions in Graves' disease (GD) occur not only in the thyroid gland, but also in the orbital connective tissue, eyelids, extraocular muscles."1.56Radioiodine therapy and Graves' disease - Myths and reality. ( Borowska, M; Czarnywojtek, A; Gut, P; Karlińska, M; Kobylecka, M; Krolicki, L; Plazinska, MT; Prasek, K; Ruchala, M; Sawicka-Gutaj, N; Wolinski, K; Zgorzalewicz-Stachowiak, M, 2020)
"Hyperthyroidism is a significant contributor to oxidative stress in patients with active TAO, which manifests as upregulated lipid peroxidation and antioxidant system activation."1.56The effect of thyroid hormone status on selected antioxidant parameters in patients with Graves' disease and active thyroid-associated orbitopathy. ( Kos-Kudła, B; Londzin-Olesik, M; Nowak, A; Nowak, M; Wielkoszyński, T, 2020)
"Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies."1.46Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice. ( Hu, X; Niu, M; Song, S; Wang, H; Wang, J; Xia, N; Xu, H; Ye, X, 2017)
"A 44-year-old male with Graves' disease ongoing for seven years presented bilateral ophthalmopathy and myxoedema of the big toes."1.39[Graves' dermopathy on the big toe]. ( Cante, V; Couderc, E; Guillet, G; Renaud, O, 2013)
"Prednisone was started 1 d after RAI and withdrawn after 6 wk."1.36Lower dose prednisone prevents radioiodine-associated exacerbation of initially mild or absent graves' orbitopathy: a retrospective cohort study. ( Bartalena, L; Compri, E; Lai, A; Marino, F; Piantanida, E; Sassi, L; Sivelli, P; Tanda, ML, 2010)
"The association of infiltrative ophthalmopathy with primary hypothyroidism is uncommon."1.35Infiltrative ophthalmopathy and primary hypothyroidism: a rare clinical manifestation of a common disease. ( Dhingra, A; Kumar, K; Rajput, R; Sen, J, 2009)
"For patients with TOA, orbital decompression seems to be an effective and safe treatment."1.34Efficacy and safety of orbital decompression in treatment of thyroid-associated ophthalmopathy: long-term follow-up of 78 patients. ( Jernfors, M; Laitinen, K; Malmberg, H; Pitkäranta, A; Setälä, K; Välimäki, MJ, 2007)
"We believe that RTX treatment in Graves' disease may cause amelioration of ophthalmopathy by depleting total lymphocytes population in the orbit."1.33Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B-cell depletion in one patient unresponsive to steroid immunosuppression. ( Avignone, S; Beck-Peccoz, P; Bonara, P; Campi, I; Guastella, C; Pirola, G; Ratiglia, R; Rossi, S; Salvi, M; Sbrozzi, F; Vannucchi, G, 2006)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19903 (5.77)18.7374
1990's0 (0.00)18.2507
2000's12 (23.08)29.6817
2010's28 (53.85)24.3611
2020's9 (17.31)2.80

Authors

AuthorsStudies
Perros, P1
Basu, A1
Boelaert, K1
Dayan, C1
Vaidya, B1
Williams, GR1
Lazarus, JH1
Hickey, J1
Drake, WM1
Crown, A1
Orme, SM1
Johnson, A1
Ray, DW1
Leese, GP1
Jones, TH1
Abraham, P1
Grossman, A1
Rees, A1
Razvi, S1
Gibb, FW1
Moran, C1
Madathil, A1
Žarković, MP1
Plummer, Z1
Jarvis, S1
Falinska, A1
Velusamy, A1
Sanderson, V1
Pariani, N1
Atkin, SL1
Syed, AA1
Sathyapalan, T1
Nag, S1
Gilbert, J1
Gleeson, H1
Levy, MJ1
Johnston, C1
Sturrock, N1
Bennett, S1
Mishra, B1
Malik, I1
Karavitaki, N1
Nakano, M1
Konishi, H1
Koshiba, M1
Zhou, J1
Yu, X1
Lou, Y1
Bao, J1
Xia, Y2
Zhu, L1
Katahira, M1
Tsunekawa, T1
Mizoguchi, A1
Yamaguchi, M1
Tsuru, K1
Takashima, H1
Terada, R1
Plazinska, MT1
Sawicka-Gutaj, N2
Czarnywojtek, A1
Wolinski, K1
Kobylecka, M1
Karlińska, M1
Prasek, K1
Zgorzalewicz-Stachowiak, M1
Borowska, M1
Gut, P1
Ruchala, M1
Krolicki, L1
Londzin-Olesik, M1
Kos-Kudła, B1
Nowak, A1
Wielkoszyński, T1
Nowak, M2
Khamisi, S1
Lundqvist, M1
Emadi, P1
Almby, K1
Ljunggren, Ö1
Karlsson, FA1
Ye, X2
Zhao, H1
Liu, J1
Lu, B1
Shao, J1
Wang, J2
Li, J1
Bai, L1
Wei, F1
Wei, M1
Xiao, Y1
Yan, W1
Wei, J1
Xia, N2
Hu, X1
Song, S1
Xu, H1
Niu, M1
Wang, H1
Meringolo, D1
Campi, I2
Costante, G1
Machen, L1
MacIntosh, P1
Neumann, S1
Krieger, CC1
Gershengorn, MC1
Smith, TJ2
Scanlan, TS2
Fernando, R2
Faßbender, J1
Holthoff, HP1
Li, Z1
Ungerer, M1
Couderc, E1
Cante, V1
Renaud, O1
Guillet, G1
Batra, R1
Krishnasamy, SK1
Buch, H1
Sandramouli, S1
Bruscolini, A1
Abbouda, A1
Locuratolo, N1
Restivo, L1
Trimboli, P1
Romanelli, F1
Erdei, A1
Paragh, G1
Kovacs, P1
Karanyi, Z1
Berenyi, E1
Galuska, L1
Lenkey, A1
Szabados, L1
Gyory, F1
Ujhelyi, B1
Berta, A1
Boda, J1
Berta, E1
Bodor, M1
Gazdag, A1
Nagy, EV1
McElnea, E1
Ní Mhéalóid, A1
Moran, S1
Kelly, R1
Fulcher, T1
Sendhil Kumaran, M1
Dutta, P1
Sakia, U1
Dogra, S1
Villagelin, D1
Romaldini, JH1
Santos, RB1
Milkos, AB1
Ward, LS1
Budny, B1
Zybek-Kocik, A1
Sowiński, J1
Ziemnicka, K1
Waligórska-Stachura, J1
Ruchała, M1
Tu, Y1
Wang, Y1
Ding, L1
Zhang, J1
Wu, W1
Karra, E1
Yousseif, A1
Rose, GE1
Baldeweg, SE1
Placzek, E1
Reese, EA1
Placzek, AT1
Schwartz, S1
Trierweiler, A1
Niziol, LM1
Raychaudhuri, N1
Atkins, S1
Grzesiuk, W1
Szydlarska, D1
Pragacz, A1
Bar-Andziak, E1
Sieminska, L1
Niedziolka, D1
Pillich, A1
Kos-Kudla, B1
Marek, B1
Borgiel-Marek, H1
Rajput, R1
Dhingra, A1
Kumar, K1
Sen, J1
Daroszewski, J1
Pawlak, E1
Karabon, L1
Frydecka, I1
Jonkisz, A1
Slowik, M1
Bolanowski, M1
Yi, BP1
Leng, SL1
Kwang, LB1
Rootman, J1
Lai, A1
Sassi, L1
Compri, E1
Marino, F1
Sivelli, P1
Piantanida, E1
Tanda, ML1
Bartalena, L1
Akarsu, E1
Buyukhatipoglu, H1
Aktaran, S1
Kurtul, N1
Shu, S1
Li, Y1
Liu, SM1
He, JS1
Giovansili, L1
Cayrolle, G1
Belange, G1
Clavel, G1
Herdan, ML1
Yoshihara, A1
Yoshimura Noh, J1
Nakachi, A1
Ohye, H1
Sato, S1
Sekiya, K1
Kosuga, Y1
Suzuki, M1
Matsumoto, M1
Kunii, Y1
Watanabe, N1
Mukasa, K1
Inoue, Y1
Ito, K2
Laurberg, P1
Berman, DC1
Andersen, S1
Bülow Pedersen, I1
Seoane Cruz, I1
Penín Álvarez, M1
Rodríguez Ferro, F1
Luna Cano, R1
Regalbuto, C1
Le Moli, R1
Muscia, V1
Russo, M1
Vigneri, R1
Pezzino, V1
Jang, SY1
Lee, SY2
Lee, EJ1
Yoon, JS2
Subekti, I1
Boedisantoso, A1
Moeloek, ND1
Waspadji, S1
Mansyur, M1
Kim, SE1
Kim, KH1
CORDES, FC1
TENGROTH, B1
BROUHON-MASSILLON, L1
Salvi, M1
Vannucchi, G1
Rossi, S1
Bonara, P1
Sbrozzi, F1
Guastella, C1
Avignone, S1
Pirola, G1
Ratiglia, R1
Beck-Peccoz, P1
Zhou, S1
Liang, Y1
Xiao, C1
Shen, H1
Pan, H1
Deng, H1
Wang, N1
Li, QQ1
Gopinath, B1
Musselman, R1
Adams, CL1
Tani, J1
Beard, N1
Wall, JR1
Velickiene, D1
Kazanavicius, G1
Danilevicius, J1
Jankauskiene, J1
Marcocci, C1
Pinchera, A1
Marinò, M1
Jernfors, M1
Välimäki, MJ1
Setälä, K1
Malmberg, H1
Laitinen, K1
Pitkäranta, A1
Laban-Guceva, N1
Antova, M1
Bogoev, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
B-cell Depletion Therapy With Rituximab for Thyroid Eye Disease[NCT02316691]2 participants (Actual)Observational2016-01-31Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for thyroxine and Graves Ophthalmopathy

ArticleYear
Effect of Addition of Thyroxine in the Treatment of Graves' Disease: A Systematic Review.
    Frontiers in endocrinology, 2020, Volume: 11

    Topics: Animals; Antithyroid Agents; Drug Therapy, Combination; Graves Disease; Graves Ophthalmopathy; Human

2020
Post-radioiodine De Novo Onset Graves' Ophthalmopathy: Case Reports and a Review of the Literature.
    Seminars in ophthalmology, 2015, Volume: 30, Issue:3

    Topics: Adult; Antithyroid Agents; Carbimazole; Diplopia; Graves Disease; Graves Ophthalmopathy; Humans; Hyp

2015
Management of patients with thyroid eye disease.
    British journal of hospital medicine (London, England : 2005), 2016, Volume: 77, Issue:1

    Topics: Adrenal Cortex Hormones; Catheter Ablation; Graves Ophthalmopathy; Hormone Replacement Therapy; Huma

2016

Trials

2 trials available for thyroxine and Graves Ophthalmopathy

ArticleYear
Efficacy and safety of tripterygium glycosides for active moderate to severe Graves' ophthalmopathy: a randomised, observer-masked, single-centre trial.
    European journal of endocrinology, 2021, Volume: 184, Issue:2

    Topics: Administration, Intravenous; Adult; Antithyroid Agents; Diplopia; Exophthalmos; Eye Pain; Female; Gl

2021
[Therapeutic effect and side effect of treatment on hyperthyroid exophthalmos with the combination of acupuncture and medication].
    Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2010, Volume: 30, Issue:10

    Topics: Acupuncture Points; Acupuncture Therapy; Adult; Combined Modality Therapy; Drug-Related Side Effects

2010

Other Studies

47 other studies available for thyroxine and Graves Ophthalmopathy

ArticleYear
Postradioiodine Graves' management: The PRAGMA study.
    Clinical endocrinology, 2022, Volume: 97, Issue:5

    Topics: Adult; Antithyroid Agents; Graves Disease; Graves Ophthalmopathy; Humans; Hyperthyroidism; Hypothyro

2022
Thyroid-Stimulating Antibody/Thyroid-Stimulating Hormone Receptor Antibody Ratio as a Sensitive Screening Test for Active Graves' Orbitopathy.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2022, Volume: 28, Issue:10

    Topics: Autoantibodies; Graves Disease; Graves Ophthalmopathy; Humans; Immunoglobulins, Thyroid-Stimulating;

2022
Detection and Correlation Analysis of Serum Uric Acid in Patients with Thyroid-Associated Ophthalmopathy.
    Computational and mathematical methods in medicine, 2022, Volume: 2022

    Topics: Glycated Hemoglobin; Graves Ophthalmopathy; Humans; Thyroid Hormones; Thyrotropin; Thyroxine; Triiod

2022
Clinical significance of thyroglobulin antibodies and thyroid peroxidase antibodies in Graves' disease: a cross-sectional study.
    Hormones (Athens, Greece), 2023, Volume: 22, Issue:2

    Topics: Autoantibodies; Clinical Relevance; Cross-Sectional Studies; Graves Disease; Graves Ophthalmopathy;

2023
Radioiodine therapy and Graves' disease - Myths and reality.
    PloS one, 2020, Volume: 15, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents; Cigarette Smoking; Female; Graves Disease; Graves Ophthalmopa

2020
The effect of thyroid hormone status on selected antioxidant parameters in patients with Graves' disease and active thyroid-associated orbitopathy.
    Endokrynologia Polska, 2020, Volume: 71, Issue:5

    Topics: Adult; Female; Graves Ophthalmopathy; Humans; Hyperthyroidism; Male; Middle Aged; Oxidative Stress;

2020
Serum thyroglobulin is associated with orbitopathy in Graves' disease.
    Journal of endocrinological investigation, 2021, Volume: 44, Issue:9

    Topics: Adult; Aged; Antithyroid Agents; Biomarkers; Female; Graves Disease; Graves Ophthalmopathy; Humans;

2021
Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: 3T3 Cells; Animals; Autoantibodies; Disease Models, Animal; Electroporation; Enzyme-Linked Immunosor

2017
Severe Graves' Orbitopathy occurring in a patient with thyroid hemiagenesis.
    Endocrine, 2018, Volume: 62, Issue:2

    Topics: Adrenal Cortex Hormones; Autoantibodies; Autoantigens; Female; Graves Disease; Graves Ophthalmopathy

2018
Considerations in Pediatric Proptosis.
    JAMA ophthalmology, 2018, 10-01, Volume: 136, Issue:10

    Topics: Adolescent; Antithyroid Agents; Blepharoptosis; Cholinesterase Inhibitors; Drug Therapy, Combination

2018
Letter to the Editor: "Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy".
    The Journal of clinical endocrinology and metabolism, 2019, 04-01, Volume: 104, Issue:4

    Topics: Graves Disease; Graves Ophthalmopathy; Humans; Thyroxine

2019
Response to Letter to the Editor: "Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy".
    The Journal of clinical endocrinology and metabolism, 2019, 04-01, Volume: 104, Issue:4

    Topics: Graves Disease; Graves Ophthalmopathy; Humans; Thyroxine

2019
Therapeutic Effects of Short Cyclic and Combined Epitope Peptides in a Long-Term Model of Graves' Disease and Orbitopathy.
    Thyroid : official journal of the American Thyroid Association, 2019, Volume: 29, Issue:2

    Topics: Adenoviridae; Animals; Disease Models, Animal; Epitopes; Female; Fibrosis; Graves Ophthalmopathy; HE

2019
[Graves' dermopathy on the big toe].
    Annales de dermatologie et de venereologie, 2013, Volume: 140, Issue:5

    Topics: Adult; Biopsy; Carbimazole; Decompression, Surgical; Fibroblasts; Foot Dermatoses; Glycosaminoglycan

2013
Dry Eye Syndrome in Non-Exophthalmic Graves' Disease.
    Seminars in ophthalmology, 2015, Volume: 30, Issue:5-6

    Topics: Adult; Dry Eye Syndromes; Female; Graves Ophthalmopathy; Humans; Immunoglobulins, Thyroid-Stimulatin

2015
Rapid response to and long-term effectiveness of anti-CD20 antibody in conventional therapy resistant Graves' orbitopathy: A five-year follow-up study.
    Autoimmunity, 2014, Volume: 47, Issue:8

    Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Female; Follow-Up Studies; Graves Ophthalmopathy; Hum

2014
Thyroid-like ophthalmopathy in a euthyroid patient receiving Ipilimumab.
    Orbit (Amsterdam, Netherlands), 2014, Volume: 33, Issue:6

    Topics: Aged; Antibodies, Monoclonal; Euthyroid Sick Syndromes; Exophthalmos; Female; Glucocorticoids; Grave

2014
Long-term follow-up and epidemiological trends in patients with pretibial myxedema: an 11-year study from a tertiary care center in northern India.
    International journal of dermatology, 2015, Volume: 54, Issue:8

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Clobetasol; Drug Therapy, Combination;

2015
Outcomes in Relapsed Graves' Disease Patients Following Radioiodine or Prolonged Low Dose of Methimazole Treatment.
    Thyroid : official journal of the American Thyroid Association, 2015, Volume: 25, Issue:12

    Topics: Adult; Antithyroid Agents; Female; Graves Disease; Graves Ophthalmopathy; Hormone Replacement Therap

2015
Nicotinamide phosphoribosyltransferase leukocyte overexpression in Graves' opthalmopathy.
    Endocrine, 2016, Volume: 53, Issue:2

    Topics: Adult; Autoantibodies; Body Mass Index; Cross-Sectional Studies; Female; Graves Ophthalmopathy; Huma

2016
Development of a Novel Thyroid Function Fluctuated Animal Model for Thyroid-Associated Ophthalmopathy.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Animals; Body Weight; Disease Models, Animal; Drug Administration Schedule; Endoplasmic Reticulum; G

2016
Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy.
    The Journal of clinical endocrinology and metabolism, 2017, 03-01, Volume: 102, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Autoradiography; Case-Control Studies; Cells, Cultured; Chromatograp

2017
Thyroid-associated orbitopathy in patients with Hashimoto's thyroiditis: a case report.
    Polskie Archiwum Medycyny Wewnetrznej, 2008, Volume: 118, Issue:5

    Topics: Adult; Anemia, Pernicious; Autoantibodies; Graves Ophthalmopathy; Hashimoto Disease; Humans; Male; M

2008
Serum concentrations of adiponectin and resistin in hyperthyroid Graves' disease patients.
    Journal of endocrinological investigation, 2008, Volume: 31, Issue:9

    Topics: Adiponectin; Autoantibodies; Female; Graves Ophthalmopathy; Humans; Male; Middle Aged; Regression An

2008
Infiltrative ophthalmopathy and primary hypothyroidism: a rare clinical manifestation of a common disease.
    Postgraduate medical journal, 2009, Volume: 85, Issue:999

    Topics: Female; Graves Ophthalmopathy; Humans; Hypothyroidism; Male; Middle Aged; Thyroxine

2009
Soluble CTLA-4 receptor an immunological marker of Graves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms.
    European journal of endocrinology, 2009, Volume: 161, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, CD; Cohort Studies; CTLA-4 Antigen; DNA; Femal

2009
Development of thyroid-related orbitopathy following cataract surgery.
    Orbit (Amsterdam, Netherlands), 2009, Volume: 28, Issue:6

    Topics: Aged; Aged, 80 and over; Female; Follow-Up Studies; Graves Ophthalmopathy; Humans; Immunoglobulins,

2009
Lower dose prednisone prevents radioiodine-associated exacerbation of initially mild or absent graves' orbitopathy: a retrospective cohort study.
    The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:3

    Topics: Adult; Aged; Chi-Square Distribution; Female; Glucocorticoids; Graves Disease; Graves Ophthalmopathy

2010
Effects of pulse methylprednisolone and oral methylprednisolone treatments on serum levels of oxidative stress markers in Graves' ophthalmopathy.
    Clinical endocrinology, 2011, Volume: 74, Issue:1

    Topics: Adult; Anti-Inflammatory Agents; Female; Glutathione; Graves Ophthalmopathy; Humans; Iodide Peroxida

2011
Graves' ophthalmopathy after total thyroidectomy for papillary carcinoma.
    Annales d'endocrinologie, 2011, Volume: 72, Issue:1

    Topics: Autoantibodies; Carcinoma, Papillary; Female; Graves Ophthalmopathy; Humans; Immunoglobulins, Thyroi

2011
Severe thyroid-associated orbitopathy in Hashimoto's thyroiditis. Report of 2 cases.
    Endocrine journal, 2011, Volume: 58, Issue:5

    Topics: Adult; Female; Graves Ophthalmopathy; Hashimoto Disease; Humans; Magnetic Resonance Imaging; Methylp

2011
Sustained control of Graves' hyperthyroidism during long-term low-dose antithyroid drug therapy of patients with severe Graves' orbitopathy.
    Thyroid : official journal of the American Thyroid Association, 2011, Volume: 21, Issue:9

    Topics: Adult; Antithyroid Agents; Biomarkers; Denmark; Drug Administration Schedule; Feasibility Studies; F

2011
[Unilateral exophthalmos and hypothyroidism].
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2012, Volume: 59, Issue:3

    Topics: Adult; Diagnosis, Differential; Exophthalmos; Eye Abnormalities; Eye Pain; Female; Graves Ophthalmop

2012
Severe Graves' ophthalmopathy after percutaneous ethanol injection in a nontoxic thyroid nodule.
    Thyroid : official journal of the American Thyroid Association, 2012, Volume: 22, Issue:2

    Topics: Administration, Cutaneous; Ethanol; Graves Ophthalmopathy; Humans; Hyperthyroidism; Immunoglobulins,

2012
Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients.
    Eye (London, England), 2012, Volume: 26, Issue:9

    Topics: Adult; Euthyroid Sick Syndromes; Eyelid Diseases; Female; Graves Ophthalmopathy; Humans; Hyperthyroi

2012
Association of TSH receptor antibody, thyroid stimulating antibody, and thyroid blocking antibody with clinical activity score and degree of severity of Graves ophthalmopathy.
    Acta medica Indonesiana, 2012, Volume: 44, Issue:2

    Topics: Adipose Tissue; Adult; Cross-Sectional Studies; Female; Graves Ophthalmopathy; Humans; Immunoglobuli

2012
Increased serum interleukin-17 in Graves' ophthalmopathy.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012, Volume: 250, Issue:10

    Topics: Adult; Female; Flow Cytometry; Graves Ophthalmopathy; Humans; Immunoassay; Immunoglobulins, Thyroid-

2012
Endocrine exophthalmos; an evaluation of present knowledge.
    American journal of ophthalmology, 1954, Volume: 38, Issue:1 1

    Topics: Exophthalmos; Graves Ophthalmopathy; Hormones; Pituitary Gland; Pituitary Gland, Anterior; Thyroxine

1954
Endocrine exophthalmos. Effects of thyrotropin preparations and the thyroxin isomers. Quantitative evaluations in guinea pigs.
    Acta ophthalmologica. Supplementum, 1961, Volume: Suppl 65

    Topics: Animals; Exophthalmos; Graves Ophthalmopathy; Guinea Pigs; Pituitary Hormones, Anterior; Thyrotropin

1961
[CONTRIBUTION TO THE EXPERIMENTAL STUDY OF ENDOCRINE EXOPHTHALMOS].
    Documenta ophthalmologica. Advances in ophthalmology, 1963, Volume: 17

    Topics: Adrenocorticotropic Hormone; Animals; Blood; Estradiol; Estrone; Exophthalmos; Fishes; Graves Ophtha

1963
Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B-cell depletion in one patient unresponsive to steroid immunosuppression.
    European journal of endocrinology, 2006, Volume: 154, Issue:4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Autoantibodies; B-Lymphocytes; Femal

2006
CD4+ T cells and the Th1/Th2 imbalance are implicated in the pathogenesis of Graves' ophthalmopathy.
    International journal of molecular medicine, 2006, Volume: 17, Issue:5

    Topics: Adolescent; Adult; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Female;

2006
Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves' disease with and without ophthalmopathy: correlation with clinical features.
    Thyroid : official journal of the American Thyroid Association, 2006, Volume: 16, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Autoantibodies; Calsequestrin; Cell Cycle Proteins; Collagen; Enzyme

2006
Predicting outcome of treatment with radiotherapy in endocrine ophthalmopathy.
    Medicina (Kaunas, Lithuania), 2007, Volume: 43, Issue:3

    Topics: Adult; Aged; Autoantibodies; C-Reactive Protein; Confidence Intervals; Data Interpretation, Statisti

2007
A treatment strategy for Graves' orbitopathy.
    Nature clinical practice. Endocrinology & metabolism, 2007, Volume: 3, Issue:5

    Topics: Antithyroid Agents; Female; Glucocorticoids; Graves Ophthalmopathy; Humans; Methimazole; Middle Aged

2007
Efficacy and safety of orbital decompression in treatment of thyroid-associated ophthalmopathy: long-term follow-up of 78 patients.
    Clinical endocrinology, 2007, Volume: 67, Issue:1

    Topics: Adult; Case-Control Studies; Chi-Square Distribution; Decompression, Surgical; Diplopia; Exophthalmo

2007
No changes in serum concentrations of interleukin 10 (IL-10) and interferon gamma (IF-gamma) before and after treatment of the thyroid eye disease (TED).
    Bosnian journal of basic medical sciences, 2007, Volume: 7, Issue:4

    Topics: Apoptosis; Biomarkers; Cytokines; Glucocorticoids; Graves Ophthalmopathy; Humans; Inflammation; Inte

2007