Page last updated: 2024-11-06

thyroxine and Glioma

thyroxine has been researched along with Glioma in 17 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"We have determined the cellular concentration of thyroxine (T4) and triiodothyronine (T3) and the activities of two brain iodothyronine deiodinases, type II (5'-D2) and type III (5-D3), in two types of tissues --tumour (26) and non-tumour (5), derived either from human gliomas with various histological malignancies or from non-tumoural surrounding brain tissue."3.72The concentration of thyroid hormones and activities of iodothyronine deiodinases are altered in human brain gliomas. ( Bonicki, W; Czernicki, Z; Michalik, R; Nauman, P; Warzecha, A, 2004)
"The uptake of 3,5,3'-triiodothyronine (T3) and thyroxine (T4) was studied in human glioma cells (Hs 683) and compared with that in several other neural cell lines."3.68Thyroid hormone transport in a human glioma cell line. ( Goncalves, E; Lakshmanan, M; Pontecorvi, A; Robbins, J, 1990)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19905 (29.41)18.7374
1990's2 (11.76)18.2507
2000's9 (52.94)29.6817
2010's1 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
van Iersel, L1
Xu, J1
Potter, BS1
Conklin, HM1
Zhang, H1
Chemaitilly, W1
van Santen, HM2
Merchant, TE1
Lin, HY3
Sun, M2
Tang, HY3
Lin, C1
Luidens, MK1
Mousa, SA2
Incerpi, S1
Drusano, GL1
Davis, FB4
Davis, PJ4
Hercbergs, A3
Ciesielski, MJ1
Leith, JT1
Cho, JY1
Shen, DH1
Yang, W1
Williams, B1
Buckwalter, TL1
La Perle, KM1
Hinkle, G1
Pozderac, R1
Kloos, R1
Nagaraja, HN1
Barth, RF1
Jhiang, SM1
Wink, MR1
Tamajusuku, AS1
Braganhol, E1
Casali, EA1
Barreto-Chaves, ML1
Sarkis, JJ1
Battastini, AM1
Nauman, P1
Bonicki, W1
Michalik, R1
Warzecha, A1
Czernicki, Z1
Thonissen, NM1
de Kraker, J1
Vulsma, T1
Shih, A2
Keating, T2
Lansing, L1
Fenstermaker, RA1
Mousa, A1
Zamoner, A1
Funchal, C1
Jacques-Silva, MC1
Gottfried, C1
Barreto Silva, FR1
Pessoa-Pureur, R1
Wu, YH1
Hammond, D1
Elkouby, A2
Ledig, M1
Mandel, P2
Farooqui, AA1
Ogilvy-Stuart, AL1
Shalet, SM1
Gattamaneni, HR1
Goncalves, E1
Lakshmanan, M1
Pontecorvi, A1
Robbins, J1
Walz, MA1
Howlett, AC1
Yusta, B2
Ortiz-Caro, J2
Pascual, A2
Aranda, A2
Montiel, F1
Villa, A1

Other Studies

17 other studies available for thyroxine and Glioma

ArticleYear
Clinical Importance of Free Thyroxine Concentration Decline After Radiotherapy for Pediatric and Adolescent Brain Tumors.
    The Journal of clinical endocrinology and metabolism, 2019, 11-01, Volume: 104, Issue:11

    Topics: Adolescent; Aging; Body Height; Brain Neoplasms; Child; Child, Preschool; Cohort Studies; Disease Pr

2019
L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
    American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:5

    Topics: Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Glioma; Humans; Hypoxia-I

2009
Radiosensitization of GL261 glioma cells by tetraiodothyroacetic acid (tetrac).
    Cell cycle (Georgetown, Tex.), 2009, Aug-15, Volume: 8, Issue:16

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Glioma; Mice; Radiation Tolerance;

2009
In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomas.
    Gene therapy, 2002, Volume: 9, Issue:17

    Topics: Animals; Blotting, Western; Brain Neoplasms; Genetic Therapy; Genetic Vectors; Glioma; Humans; Immun

2002
Thyroid hormone upregulates ecto-5'-nucleotidase/CD73 in C6 rat glioma cells.
    Molecular and cellular endocrinology, 2003, Jul-31, Volume: 205, Issue:1-2

    Topics: 5'-Nucleotidase; Animals; Cell Line, Tumor; Dactinomycin; Dose-Response Relationship, Drug; Glioma;

2003
The concentration of thyroid hormones and activities of iodothyronine deiodinases are altered in human brain gliomas.
    Folia neuropathologica, 2004, Volume: 42, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Brain Neoplasms; Female; Glioma; Humans; Iodide Peroxidase; Male;

2004
Changes in thyroid hormone state in children receiving chemotherapy.
    Clinical endocrinology, 2005, Volume: 62, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool;

2005
Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells.
    Cancer research, 2006, Jul-15, Volume: 66, Issue:14

    Topics: Animals; Cell Growth Processes; Cell Line, Tumor; Enzyme Activation; Glioma; Integrin alphaVbeta3; M

2006
Thyroid hormones reorganize the cytoskeleton of glial cells through Gfap phosphorylation and Rhoa-dependent mechanisms.
    Cellular and molecular neurobiology, 2007, Volume: 27, Issue:7

    Topics: Animals; Astrocytes; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cytoskeleton; Glial Fibrillar

2007
Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediated.
    Carcinogenesis, 2008, Volume: 29, Issue:1

    Topics: Apoptosis; Brain Neoplasms; Cyclooxygenase 2; Enzyme Activation; Extracellular Signal-Regulated MAP

2008
Effect of hydrocortisone and thyroxine on ATPase activities of neuronal and glial cell lines in culture.
    Neurochemical research, 1982, Volume: 7, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Astrocytes; Ca(2+) Mg(2+)-ATPase; Cell Line; Cricetinae; Glioma;

1982
Effect of hydrocortisone and thyroxine on arylsulphatases A and B of cultured cells of neuronal and glial origin.
    Journal of neurochemistry, 1977, Volume: 29, Issue:2

    Topics: Animals; Arylsulfatases; Cells, Cultured; Cricetinae; Galactosidases; Glioma; Hydrocortisone; Kineti

1977
Thyroid function after treatment of brain tumors in children.
    The Journal of pediatrics, 1991, Volume: 119, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine

1991
Thyroid hormone transport in a human glioma cell line.
    Molecular and cellular endocrinology, 1990, Mar-05, Volume: 69, Issue:2-3

    Topics: Aminoisobutyric Acids; Antimycin A; Binding, Competitive; Biological Transport; Cadaverine; Cell Mem

1990
Thyroid effects on adenosine 3',5'-monophosphate levels and adenylate cyclase in cultured neuroblastoma cells.
    Endocrinology, 1987, Volume: 120, Issue:4

    Topics: Adenylyl Cyclases; Alprostadil; Animals; Astrocytoma; Cell Line; Colforsin; Cyclic AMP; Glioma; Guan

1987
Mechanism of L-triiodothyronine (T3) uptake by glial C6 cells: regulation by butyrate.
    Molecular and cellular endocrinology, 1988, Volume: 58, Issue:2-3

    Topics: Animals; Antimycin A; Azides; Butyrates; Cell Membrane Permeability; Cyanides; Glioma; Rats; Sodium

1988
Identification and characterization of L-triiodothyronine receptors in cells of glial and neuronal origin.
    Endocrinology, 1986, Volume: 119, Issue:5

    Topics: Animals; Butyrates; Butyric Acid; Cell Line; Cell Nucleus; Glioma; Kinetics; Mice; Neuroblastoma; Ne

1986