thyroxine has been researched along with Generalized Resistance to Thyroid Hormone in 91 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Iodine deficiency goiter can develop in children on a restrictive diet and most have normal thyroid function." | 8.12 | Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha. ( Quintos, JB; Sasidharan Pillai, S, 2022) |
| "We describe a case of euthyroid hyperthyroxinemia in whom clinical and laboratory investigations strongly supported the diagnosis of generalised thyroid hormone resistance." | 7.70 | A case of familial euthyroid hyperthyroxinemia--thyroid hormone resistance syndrome? ( Garg, MK; Saini, JS, 1999) |
| " Missense mutations of the TTR gene produce familial amyloidotic polyneuropathy and rarely, euthyroid hyperthyroxinemia (EHT)." | 7.69 | A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. ( Byrne, MM; Marinov, VS; Refetoff, S; Sunthornthepvarakul, T; Tunca, H; Weiss, RE, 1996) |
| " During pregnancy, mildly elevated maternal free thyroxine levels less than 20% above the upper limit may not be harmful to unaffected fetuses." | 4.98 | Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature. ( Guan, H; Guo, H; Guo, R; Li, Y; Shan, Z; Wu, D, 2018) |
| " For goitrous fetal hypothyroidism leading to hydramnios, repeated intra-amniotic injections of thyroxine have been reported to decrease the size of the fetal thyroid." | 4.90 | Fetal thyroïdology. ( Luton, D; Polak, M, 2014) |
| "Iodine deficiency goiter can develop in children on a restrictive diet and most have normal thyroid function." | 4.12 | Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha. ( Quintos, JB; Sasidharan Pillai, S, 2022) |
| " Some patients receive l-thyroxine treatment for apparent hypothyroidism." | 3.85 | Thyroid hormone resistance syndrome - own experiences. ( Horodnicka-Józwa, A; Jackowski, T; Petriczko, E; Walczak, M, 2017) |
| "Levothyroxine (l-T4) is commonly employed to correct hormone deficiency in children with congenital hypothyroidism (CH) and in adult patients with iatrogenic hypothyroidism." | 3.80 | The different requirement of L-T4 therapy in congenital athyreosis compared with adult-acquired hypothyroidism suggests a persisting thyroid hormone resistance at the hypothalamic-pituitary level. ( Agretti, P; Bagattini, B; Ciampi, M; Cosmo, CD; Marco, GD; Montanelli, L; Piaggi, P; Tonacchera, M; Vitti, P, 2014) |
| " It results from reduced intracellular action of thyroid hormones (TH) genetically determined and manifests as persistent hyperthyroxinemia with non-suppressed thyroid-stimulating hormone (TSH)." | 3.80 | A case of thyroid hormone resistance: a rare mutation. ( Aragüés, JM; Barbosa, AP; Gonçalves, AP; Mascarenhas, M; Nobre, E, 2014) |
| " The patient subsequently developed hypothyroidism and required a much higher dose of levothyroxine than his weight-based estimate of a full replacement dose to maintain euthyroidism." | 3.76 | Resistance to thyroid hormone in a patient with coexisting Graves' disease. ( Chaidarun, S; Sivakumar, T, 2010) |
| " The proposita had a positive thyrotropin (TSH) newborn screening test (350 mU/L, confirmed) with normal thyroxine (T4) and no clinical signs of hypothyroidism." | 3.73 | Resistance to thyroid hormone in a patient with thyroid dysgenesis. ( Croxson, M; Grasberger, H; Refetoff, S; Ringkananont, U, 2005) |
| "We describe a case of euthyroid hyperthyroxinemia in whom clinical and laboratory investigations strongly supported the diagnosis of generalised thyroid hormone resistance." | 3.70 | A case of familial euthyroid hyperthyroxinemia--thyroid hormone resistance syndrome? ( Garg, MK; Saini, JS, 1999) |
| " Missense mutations of the TTR gene produce familial amyloidotic polyneuropathy and rarely, euthyroid hyperthyroxinemia (EHT)." | 3.69 | A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. ( Byrne, MM; Marinov, VS; Refetoff, S; Sunthornthepvarakul, T; Tunca, H; Weiss, RE, 1996) |
| "The adverse health effects of thyrotoxicosis have been carefully documented and most practitioners are familiar with the clinical consequences for the patient." | 2.40 | Adverse effects of thyroid hormones. ( Williams, JB, 1997) |
| " Our findings indicate that target genes other than Hcn2 and Hcn4 mediate T3-induced tachycardia and suggest that treatment of RTHα patients with thyroxine in high dosage without concomitant tachycardia, is possible." | 1.91 | Resistance to thyroid hormone induced tachycardia in RTHα syndrome. ( Arner, A; Boysen, TJ; Chatterjee, K; Dalley, JW; Dore, R; Franke, A; Geißler, C; Hollidge, S; Iwen, KA; Johann, K; Kirchner, H; Krause, C; Lopez-Alcantara, N; Lorenz, K; Lyons, G; Mittag, J; Moran, C; Oelkrug, R; Pedaran, M; Rennie, KL; Resch, J; Sayk, F; Sentis, SC; Watson, L, 2023) |
| "They had similar clinical (macrocephaly, broad faces, skin tags, motor dyspraxia, slow speech), biochemical (subnormal ratio of free thyroxine:free tri-iodothyronine [T3], low concentration of total reverse T3, high concentration of creatine kinase, mild anaemia), and radiological (thickened calvarium) features to patients with TRα1-mediated resistance to thyroid hormone, although our patients had a heterozygous mis-sense mutation (Ala263Val) in both TRα1 and TRα2 proteins." | 1.40 | Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor (TR)α1 and TRα2: clinical, biochemical, and genetic analyses of three related patients. ( Agostini, M; Aylwin, S; Buchanan, C; Chatterjee, KK; Chrysis, D; Efthymiadou, A; Gurnell, M; Halsall, D; Lyons, G; Moran, C; Offiah, AC; Poole, K; Rajanayagam, O; Schoenmakers, E; Schoenmakers, N; Visser, WE, 2014) |
| "In Patient 1, histology showed a papillary thyroid carcinoma pT2." | 1.37 | Differentiated thyroid cancer in two patients with resistance to thyroid hormone. ( Capoluongo, E; Concolino, P; Corsello, SM; Locantore, P; Lovicu, RM; Paragliola, RM; Pontecorvi, A; Senes, P, 2011) |
| "Familial thyroid hormone resistance (Refetoff syndrome) was suspected and could be confirmed by detection of a pathogenic mutation within the beta-thyroidhormone receptor gene." | 1.36 | [A 46-year-old patient with atrial fibrillation, elevated thyroid hormones and normal thyrotropine]. ( Gutt, B; Opherk, IV; Schumm-Draeger, PM; Siegmund, T; Volz, S, 2010) |
| "These results indicated that Graves' disease (GD) caused primary hyperthyroidism." | 1.36 | Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). ( Sato, H, 2010) |
| "Tachycardia was abated (84 beats/min), weight gain was 3 kg in 1 yr, and SHBG was 102 nmol/liter." | 1.35 | Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8. ( d'Herbomez, M; Gottrand, F; Jansen, J; Ladsous, M; Pigeyre, M; Proust-Lemoine, E; Visser, TJ; Wémeau, JL, 2008) |
| "Hyperthyroidism is an established risk factor for osteoporosis." | 1.32 | A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone. ( Cheng, SY; Harvey, CB; Kaneshige, K; Kaneshige, M; O'Shea, PJ; Suzuki, H; Williams, GR, 2003) |
| "We failed to find evidence of generalized resistance to thyroid hormone." | 1.29 | ADHD and thyroid abnormalities: a research note. ( Biederman, J; Guite, J; Harding, M; Spencer, T; Wilens, T, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (20.88) | 18.2507 |
| 2000's | 25 (27.47) | 29.6817 |
| 2010's | 33 (36.26) | 24.3611 |
| 2020's | 14 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Goettemoeller, T | 1 |
| McShane, AJ | 1 |
| Rao, P | 1 |
| Salas-Lucia, F | 1 |
| França, MM | 1 |
| Amrhein, JA | 1 |
| Weir, JE | 1 |
| Dumitrescu, AM | 3 |
| Refetoff, S | 11 |
| Santos Mata, MA | 1 |
| Ariza Jimenez, AB | 1 |
| Macias Lopez, F | 1 |
| de la Camara Moraño, C | 1 |
| Ding, X | 1 |
| Wang, Y | 4 |
| Liu, J | 1 |
| Wang, G | 1 |
| Corsello, A | 1 |
| Sasidharan Pillai, S | 1 |
| Quintos, JB | 1 |
| Liu, Y | 3 |
| Ma, M | 3 |
| Li, L | 3 |
| Liu, F | 3 |
| Li, Z | 3 |
| Yu, L | 3 |
| Yang, T | 3 |
| Gao, S | 6 |
| Yang, R | 3 |
| Yu, C | 4 |
| Corica, D | 2 |
| Licenziati, MR | 2 |
| Calcaterra, V | 2 |
| Currò, M | 2 |
| Di Mento, C | 2 |
| Curatola, S | 2 |
| Zuccotti, G | 2 |
| Alibrandi, A | 2 |
| Ientile, R | 2 |
| Aversa, T | 2 |
| Wasniewska, M | 2 |
| Ye, Y | 1 |
| Li, Y | 3 |
| Ma, Q | 1 |
| Zeng, H | 1 |
| Luo, Y | 1 |
| Liang, Y | 1 |
| Liu, L | 2 |
| Lin, X | 1 |
| Yu, G | 1 |
| Song, C | 1 |
| Wan, H | 1 |
| Shen, J | 1 |
| Dore, R | 1 |
| Watson, L | 2 |
| Hollidge, S | 1 |
| Krause, C | 1 |
| Sentis, SC | 1 |
| Oelkrug, R | 1 |
| Geißler, C | 1 |
| Johann, K | 1 |
| Pedaran, M | 1 |
| Lyons, G | 3 |
| Lopez-Alcantara, N | 1 |
| Resch, J | 1 |
| Sayk, F | 1 |
| Iwen, KA | 1 |
| Franke, A | 1 |
| Boysen, TJ | 1 |
| Dalley, JW | 1 |
| Lorenz, K | 1 |
| Moran, C | 3 |
| Rennie, KL | 1 |
| Arner, A | 1 |
| Kirchner, H | 1 |
| Chatterjee, K | 2 |
| Mittag, J | 1 |
| Çetin, S | 1 |
| Güven, M | 1 |
| Bolayır, B | 1 |
| Şimşek, M | 1 |
| Soylu, H | 1 |
| Geneş, D | 1 |
| Ay, N | 1 |
| Diri, H | 1 |
| Fujisawa, H | 1 |
| Gagné, J | 1 |
| Dieu, X | 1 |
| Sueur, G | 1 |
| Moal, V | 1 |
| Boux de Casson, F | 1 |
| Bouzamondo, N | 1 |
| Bouhours, N | 1 |
| Briet, C | 2 |
| Illouz, F | 2 |
| Reynier, P | 1 |
| Coutant, R | 1 |
| Rodien, P | 3 |
| Mirebeau-Prunier, D | 2 |
| Timmons, JG | 1 |
| Mukhopadhyay, B | 1 |
| le Maire, A | 1 |
| Bouhours-Nouet, N | 1 |
| Soamalala, J | 1 |
| Paloni, M | 1 |
| Guee, L | 1 |
| Heron, D | 1 |
| Mignot, C | 1 |
| Joubert, F | 1 |
| Bourguet, W | 1 |
| Flamant, F | 1 |
| Guyot, R | 1 |
| Lauffer, P | 1 |
| Bikker, H | 1 |
| Garrelfs, MR | 1 |
| Hillebrand, JJG | 1 |
| de Sonnaville, MCS | 1 |
| Zwaveling-Soonawala, N | 2 |
| van Trotsenburg, ASP | 1 |
| Agostini, M | 2 |
| McGowan, A | 1 |
| Schoenmakers, E | 2 |
| Fairall, L | 1 |
| Rajanayagam, O | 4 |
| Offiah, A | 1 |
| Barton, J | 1 |
| Price, S | 1 |
| Schwabe, J | 1 |
| Jackowski, T | 1 |
| Petriczko, E | 1 |
| Horodnicka-Józwa, A | 1 |
| Walczak, M | 1 |
| Zhao, J | 1 |
| Yao, J | 1 |
| Wang, H | 1 |
| Shang, H | 1 |
| Zhang, R | 1 |
| Cui, Y | 1 |
| Wang, L | 1 |
| Dong, J | 1 |
| Liao, L | 1 |
| Ramos, LS | 1 |
| Kizys, MML | 1 |
| Kunii, IS | 1 |
| Spinola-Castro, AM | 1 |
| Nesi-França, S | 1 |
| Guerra, RA | 1 |
| Camacho, CP | 1 |
| Martins, JRM | 1 |
| Maciel, RMB | 1 |
| Dias-da-Silva, MR | 1 |
| Chiamolera, MI | 1 |
| Wu, D | 1 |
| Guo, R | 1 |
| Guo, H | 1 |
| Guan, H | 1 |
| Shan, Z | 1 |
| Wejaphikul, K | 1 |
| Groeneweg, S | 2 |
| Hilhorst-Hofstee, Y | 1 |
| Chatterjee, VK | 5 |
| Peeters, RP | 4 |
| Meima, ME | 2 |
| Visser, WE | 5 |
| Roelfsema, F | 1 |
| Veldhuis, JD | 1 |
| van Mullem, AA | 1 |
| Chrysis, D | 2 |
| Eythimiadou, A | 1 |
| Chroni, E | 1 |
| Tsatsoulis, A | 1 |
| de Rijke, YB | 1 |
| Visser, TJ | 4 |
| Zavacki, AM | 1 |
| Larsen, PR | 1 |
| Polak, M | 1 |
| Luton, D | 1 |
| Tsunekawa, K | 1 |
| Murakami, M | 1 |
| Köhrle, J | 1 |
| Schoenmakers, N | 1 |
| Offiah, AC | 1 |
| Poole, K | 1 |
| Halsall, D | 2 |
| Gurnell, M | 2 |
| Efthymiadou, A | 1 |
| Buchanan, C | 1 |
| Aylwin, S | 1 |
| Chatterjee, KK | 1 |
| Diaz, A | 1 |
| Lipman Diaz, EG | 1 |
| Cardoso, LF | 1 |
| Maciel, LM | 1 |
| Paula, FJ | 1 |
| Bagattini, B | 1 |
| Cosmo, CD | 1 |
| Montanelli, L | 2 |
| Piaggi, P | 1 |
| Ciampi, M | 1 |
| Agretti, P | 2 |
| Marco, GD | 1 |
| Vitti, P | 2 |
| Tonacchera, M | 2 |
| Gonçalves, AP | 1 |
| Aragüés, JM | 1 |
| Nobre, E | 1 |
| Barbosa, AP | 1 |
| Mascarenhas, M | 1 |
| Tylki-Szymańska, A | 1 |
| Acuna-Hidalgo, R | 1 |
| Krajewska-Walasek, M | 1 |
| Lecka-Ambroziak, A | 1 |
| Steehouwer, M | 1 |
| Gilissen, C | 1 |
| Brunner, HG | 1 |
| Jurecka, A | 1 |
| Różdżyńska-Świątkowska, A | 1 |
| Hoischen, A | 1 |
| Chrzanowska, KH | 1 |
| Krude, H | 1 |
| Kühnen, P | 1 |
| Biebermann, H | 1 |
| Ma, S | 1 |
| Hu, M | 1 |
| Yang, H | 1 |
| Lian, X | 1 |
| Jiang, Y | 1 |
| van Gucht, AL | 1 |
| Fliers, E | 1 |
| Wennink, JM | 1 |
| Henny, C | 1 |
| van Trotsenburg, AS | 1 |
| Bayraktaroglu, T | 1 |
| Noel, J | 1 |
| Alagol, F | 1 |
| Colak, N | 1 |
| Mukaddes, NM | 1 |
| Burman, KD | 1 |
| Kim, TJ | 1 |
| Travers, S | 1 |
| Dhingra, S | 1 |
| Owen, PJ | 2 |
| Lazarus, JH | 2 |
| Amin, P | 1 |
| John, R | 1 |
| Opherk, IV | 1 |
| Gutt, B | 1 |
| Volz, S | 1 |
| Siegmund, T | 1 |
| Schumm-Draeger, PM | 1 |
| Guran, T | 1 |
| Turan, S | 1 |
| Bircan, R | 1 |
| Bereket, A | 1 |
| Sivakumar, T | 1 |
| Chaidarun, S | 1 |
| Sato, H | 1 |
| Weiss, RE | 6 |
| Dumitrescu, A | 1 |
| Filho, HC | 1 |
| Marui, S | 1 |
| Manna, TD | 1 |
| Brust, ES | 1 |
| Radonsky, V | 1 |
| Kuperman, H | 1 |
| Dichtchekenian, V | 1 |
| Setian, N | 1 |
| Damiani, D | 1 |
| Krysiak, R | 2 |
| Okopien, B | 2 |
| Paragliola, RM | 1 |
| Lovicu, RM | 1 |
| Locantore, P | 1 |
| Senes, P | 1 |
| Concolino, P | 1 |
| Capoluongo, E | 1 |
| Pontecorvi, A | 1 |
| Corsello, SM | 1 |
| Anzai, R | 1 |
| Adachi, M | 1 |
| Sho, N | 1 |
| Muroya, K | 1 |
| Asakura, Y | 1 |
| Onigata, K | 2 |
| Beato-Víbora, P | 1 |
| Arroyo-Díez, J | 1 |
| Rodríguez-López, R | 1 |
| O'Shea, PJ | 1 |
| Harvey, CB | 1 |
| Suzuki, H | 1 |
| Kaneshige, M | 1 |
| Kaneshige, K | 1 |
| Cheng, SY | 1 |
| Williams, GR | 1 |
| Dundar, B | 1 |
| Bober, E | 1 |
| Büyükgebiz, A | 1 |
| Bayer, Y | 1 |
| Fasshauer, M | 1 |
| Paschke, R | 1 |
| Chang, AY | 1 |
| Chamberlain-Shea, H | 1 |
| Carr, B | 1 |
| Grasberger, H | 1 |
| Ringkananont, U | 1 |
| Croxson, M | 1 |
| Herman, ZS | 1 |
| Mamanasiri, S | 1 |
| Yesil, S | 1 |
| Liao, XH | 1 |
| Demir, T | 1 |
| Di Cosmo, C | 1 |
| De Marco, G | 1 |
| Banco, M | 1 |
| Perri, A | 1 |
| Gianetti, E | 1 |
| Pinchera, A | 1 |
| Hamon, B | 1 |
| Hamon, P | 1 |
| Bovier-Lapierre, M | 1 |
| Pugeat, M | 1 |
| Savagner, F | 1 |
| Orgiazzi, J | 1 |
| Wémeau, JL | 2 |
| Pigeyre, M | 1 |
| Proust-Lemoine, E | 1 |
| d'Herbomez, M | 2 |
| Gottrand, F | 1 |
| Jansen, J | 1 |
| Ladsous, M | 1 |
| Spencer, T | 1 |
| Biederman, J | 1 |
| Wilens, T | 1 |
| Guite, J | 1 |
| Harding, M | 1 |
| Hayashi, Y | 2 |
| Sarne, DH | 1 |
| Yen, PM | 2 |
| Sunthornthepvarakul, T | 2 |
| Marcocci, C | 1 |
| Chin, WW | 1 |
| Wong, GW | 1 |
| Shek, CC | 1 |
| Lam, ST | 1 |
| Tsui, MK | 1 |
| Leung, SS | 1 |
| Marinov, VS | 1 |
| Tunca, H | 1 |
| Byrne, MM | 1 |
| Ghazi, AA | 1 |
| Akiyoshi, F | 1 |
| Okamura, K | 1 |
| Fujikawa, M | 1 |
| Sato, K | 1 |
| Yoshinari, M | 1 |
| Mizokami, T | 1 |
| Hattori, K | 1 |
| Kuwayama, A | 1 |
| Takahashi, Y | 1 |
| Fujishima, M | 1 |
| Takamatsu, J | 1 |
| Ito, M | 1 |
| Yamano, Y | 1 |
| Fukao, T | 1 |
| Sakane, S | 1 |
| Ohsawa, N | 1 |
| Yagi, H | 1 |
| Pohlenz, J | 2 |
| Sakurai, A | 1 |
| Williams, JB | 1 |
| Reinhardt, W | 1 |
| Jockenhövel, F | 1 |
| Deuble, J | 1 |
| Reinwein, D | 1 |
| Mann, K | 1 |
| Barbar, I | 1 |
| Jones, MK | 1 |
| Abel, ED | 1 |
| Kaulbach, HC | 1 |
| Campos-Barros, A | 1 |
| Ahima, RS | 1 |
| Boers, ME | 1 |
| Hashimoto, K | 1 |
| Forrest, D | 1 |
| Wondisford, FE | 1 |
| Asteria, C | 1 |
| Collingwood, TN | 1 |
| Persani, L | 2 |
| Romoli, R | 1 |
| Mannavola, D | 2 |
| Zamperini, P | 1 |
| Buzi, F | 1 |
| Ciralli, F | 1 |
| Beck-Peccoz, P | 3 |
| Menzaghi, C | 1 |
| Balsamo, A | 1 |
| Di Paola, R | 1 |
| Gallone, G | 1 |
| Rossi, C | 1 |
| Tassi, V | 1 |
| Fonzo, D | 1 |
| De Filippis, V | 1 |
| Sarkissian, G | 1 |
| Dace, A | 1 |
| Mesmacque, A | 1 |
| Bony-Trifunovic, H | 1 |
| Malezet-Desmoulins, C | 1 |
| Torresani, J | 2 |
| Margotat, A | 2 |
| Zargar, AH | 1 |
| Laway, BA | 1 |
| Masoodi, SR | 1 |
| Wani, MM | 1 |
| Bashir, MI | 1 |
| Wani, AI | 1 |
| Salahuddin, M | 1 |
| Benvenga, S | 1 |
| Robbins, J | 1 |
| Macchia, PE | 1 |
| Pannain, S | 1 |
| Lau, IT | 1 |
| Ho, H | 1 |
| Ercan-Fang, S | 1 |
| Schwartz, HL | 1 |
| Mariash, CN | 1 |
| Oppenheimer, JH | 1 |
| Brown, NS | 1 |
| Smart, A | 1 |
| Sharma, V | 1 |
| Brinkmeier, ML | 1 |
| Greenlee, L | 1 |
| Camper, SA | 1 |
| Jensen, DR | 1 |
| Eckel, RH | 1 |
| Krezel, W | 1 |
| Chambon, P | 1 |
| Haugen, BR | 1 |
| Vlaeminck-Guillem, V | 1 |
| Decoulx, M | 1 |
| Garg, MK | 1 |
| Saini, JS | 1 |
| Ciulla, MM | 1 |
| Paliotti, R | 1 |
| Cortelazzi, D | 1 |
| Tortora, G | 1 |
| Barelli, MV | 1 |
| Buonamici, V | 1 |
| Magrini, F | 1 |
| Phillips, SA | 1 |
| Rotman-Pikielny, P | 1 |
| Lazar, J | 1 |
| Ando, S | 1 |
| Hauser, P | 1 |
| Skarulis, MC | 1 |
| Brucker-Davis, F | 1 |
| Schneider, MJ | 1 |
| Fiering, SN | 1 |
| Pallud, SE | 1 |
| Parlow, AF | 1 |
| St Germain, DL | 1 |
| Galton, VA | 1 |
| Vannucchi, G | 1 |
| Fugazzola, L | 1 |
| Cerutti, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation. A Correlation Study[NCT01145040] | 138 participants (Actual) | Observational | 2010-06-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for thyroxine and Generalized Resistance to Thyroid Hormone
| Article | Year |
|---|---|
Hyperthyroxinemia with a non-suppressed TSH: how to confidently reach a diagnosis in this clinical conundrum.
Topics: Adult; Female; Humans; Hyperthyroxinemia; Pituitary Neoplasms; Thyroid Function Tests; Thyroid Hormo | 2020 |
Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Hashimoto Disease; Humans; Hypothyroidism; Mutation; Postp | 2018 |
Thyrotropin secretion patterns in health and disease.
Topics: Adult; Animals; Circadian Rhythm; Female; Health Status; Humans; Hypothalamo-Hypophyseal System; Hyp | 2013 |
Fetal thyroïdology.
Topics: Adolescent; Adult; Amnion; Antithyroid Agents; Female; Fetal Diseases; Graves Disease; Humans; Hyper | 2014 |
[Thyroid disease caused by receptor abnormality].
Topics: Biomarkers; Humans; Hyperpituitarism; Hypothyroidism; Molecular Diagnostic Techniques; Mutation; Thy | 2014 |
Hypothyroidism.
Topics: Child; Congenital Hypothyroidism; Hashimoto Disease; Hormone Replacement Therapy; Humans; Hypothyroi | 2014 |
The multiple effects of thyroid disorders on bone and mineral metabolism.
Topics: Animals; Bone and Bones; Calcification, Physiologic; Calcium; Databases, Bibliographic; Epiphyses; H | 2014 |
Treatment of congenital thyroid dysfunction: Achievements and challenges.
Topics: Congenital Hypothyroidism; Hormone Replacement Therapy; Humans; Hydrolases; Infant, Newborn; Iodide | 2015 |
Therapeutic applications of thyroid hormone analogues in resistance to thyroid hormone (RTH) syndromes.
Topics: Biomimetic Materials; Female; Humans; Male; Monocarboxylic Acid Transporters; Mutation; Signal Trans | 2017 |
Long-term 3,5,3'-triiodothyroacetic acid therapy in a child with hyperthyroidism caused by thyroid hormone resistance: pharmacological study and therapeutic recommendations.
Topics: Adolescent; Adult; Atrial Premature Complexes; Attention Deficit Disorder with Hyperactivity; Child; | 2012 |
[Thyroid hormone resistance syndrome].
Topics: Diagnosis, Differential; Humans; Thyroid Hormone Resistance Syndrome; Thyrotropin; Thyroxine; Triiod | 2006 |
[Resistance to thyrotropin (TSH) (TSH receptor gene mutations in human)].
Topics: Diagnosis, Differential; Humans; Infant, Newborn; Mutation; Neonatal Screening; Prognosis; Receptors | 2006 |
Adverse effects of thyroid hormones.
Topics: Aging; Cardiovascular Diseases; Clinical Trials as Topic; Euthyroid Sick Syndromes; Female; Humans; | 1997 |
1 trial available for thyroxine and Generalized Resistance to Thyroid Hormone
| Article | Year |
|---|---|
Can a novel drug dose be used for T3 suppression test?
Topics: Humans; Prospective Studies; Tachycardia; Thyroid Hormone Resistance Syndrome; Thyrotropin; Thyroxin | 2023 |
77 other studies available for thyroxine and Generalized Resistance to Thyroid Hormone
| Article | Year |
|---|---|
Misleading FT4 and FT3 Due to Immunoassay Interference From Autoantibodies.
Topics: Aged; Autoantibodies; Diagnostic Errors; Female; Humans; Immunoassay; Pituitary Neoplasms; Thyroid F | 2022 |
Severe Resistance to Thyroid Hormone Beta in a Patient with Athyreosis.
Topics: Congenital Hypothyroidism; Humans; Mutation; Thyroid Dysgenesis; Thyroid Hormone Receptors beta; Thy | 2022 |
Thyroid Hormone Resistance: Multicentrical Case Series Study.
Topics: Adolescent; Adult; Child; Child, Preschool; Cross-Sectional Studies; Humans; Infant; Infant, Newborn | 2022 |
Impaired Sensitivity to Thyroid Hormones Is Associated With Elevated Homocysteine Levels in the Euthyroid Population.
Topics: Adult; Congenital Hypothyroidism; Homocysteine; Humans; Receptors, Thyrotropin; Thyroid Function Tes | 2022 |
[Thyroxine replacement therapy in patients with thyroid cancer and thyroid hormone resistance syndrome].
Topics: Humans; Thyroid Hormone Resistance Syndrome; Thyroid Hormones; Thyroid Neoplasms; Thyrotropin; Thyro | 2022 |
Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha.
Topics: Child; Female; Goiter; Goiter, Endemic; Humans; Hypothyroidism; Iodine; Malnutrition; Thyroglobulin; | 2022 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Topics: Coronary Disease; Dyslipidemias; Glucose; Humans; Retrospective Studies; Thyroid Hormone Resistance | 2023 |
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome | 2023 |
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome | 2023 |
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome | 2023 |
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome | 2023 |
Association of multiple blood metals with thyroid function in general adults: A cross-sectional study.
Topics: Adult; Bayes Theorem; Copper; Cross-Sectional Studies; Humans; Iodine; Iron; Manganese; Thyroid Horm | 2023 |
Resistance to thyroid hormone induced tachycardia in RTHα syndrome.
Topics: Animals; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Mice; Mutation; Tachyca | 2023 |
Very Severe Resistance to Thyroid Hormone β in One of Three Affected Members of a Family with a Novel Mutation in the
Topics: Adolescent; Family; Female; Fibroblasts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro | 2019 |
Apparent resistance to thyroid hormones: From biological interference to genetics.
Topics: Adolescent; Adult; Aged; Carrier Proteins; Child; Child, Preschool; Diagnostic Errors; Female; Human | 2019 |
Two Novel Cases of Resistance to Thyroid Hormone Due to
Topics: Child, Preschool; Computer Simulation; Dimerization; Female; Heterozygote; Humans; Infant; Infant, N | 2020 |
Defective Levothyroxine Response in a Patient with Dyshormonogenic Congenital Hypothyroidism Caused by a Concurrent Pathogenic Variant in Thyroid Hormone Receptor-β.
Topics: Child, Preschool; Congenital Hypothyroidism; Consanguinity; Female; Humans; Pedigree; Symporters; Th | 2021 |
Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.
Topics: Adolescent; Genetic Predisposition to Disease; Genotype; Humans; Male; Mutation; Phenotype; Symptom | 2017 |
Thyroid hormone resistance syndrome - own experiences.
Topics: Adolescent; Child; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Pituitary Gland; Thyroid H | 2017 |
Pituitary resistance to thyroid hormone caused by a novel mutation (H435A) in the thyroid hormone receptor beta: A case report.
Topics: Diagnosis, Differential; Female; Humans; Hyperthyroidism; Magnetic Resonance Imaging; Middle Aged; M | 2018 |
Assessing the clinical and molecular diagnosis of inherited forms of impaired sensitivity to thyroid hormone from a single tertiary center.
Topics: Adolescent; Adult; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Infant; Male; M | 2018 |
Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β.
Topics: Female; Humans; Mutation; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Thyroid H | 2019 |
Clinical phenotype of a new type of thyroid hormone resistance caused by a mutation of the TRα1 receptor: consequences of LT4 treatment.
Topics: Child; Constipation; Drug Resistance; Dyslipidemias; Female; Frameshift Mutation; Heterozygote; Huma | 2013 |
RTHα, a newly recognized phenotype of the resistance to thyroid hormone (RTH) syndrome in patients with THRA gene mutations.
Topics: Female; Frameshift Mutation; Humans; Male; Thyroid Hormone Receptors alpha; Thyroid Hormone Resistan | 2013 |
Thyroxine: beneficial for mutated TRα receptors thwarting thyroid hormone action?
Topics: Alternative Splicing; Humans; Mutation, Missense; Protein Isoforms; Thyroid Hormone Receptors alpha; | 2014 |
Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor (TR)α1 and TRα2: clinical, biochemical, and genetic analyses of three related patients.
Topics: Adult; Alternative Splicing; Amino Acid Substitution; Family Health; Female; Gait Apraxia; Heterozyg | 2014 |
The different requirement of L-T4 therapy in congenital athyreosis compared with adult-acquired hypothyroidism suggests a persisting thyroid hormone resistance at the hypothalamic-pituitary level.
Topics: Adolescent; Adult; Congenital Hypothyroidism; Female; Hormone Replacement Therapy; Humans; Hypothala | 2014 |
A case of thyroid hormone resistance: a rare mutation.
Topics: Aged; DNA; Exons; Female; Genes, erbA; Goiter; Humans; Hyperthyroxinemia; Mutation; Polymerase Chain | 2014 |
Thyroid hormone resistance syndrome due to mutations in the thyroid hormone receptor α gene (THRA).
Topics: Adolescent; Adult; Child; Child, Preschool; DNA Mutational Analysis; Facies; Female; Genetic Associa | 2015 |
Periodic Paralysis as a New Phenotype of Resistance to Thyroid Hormone Syndrome in a Chinese Male Adult.
Topics: Adult; DNA; Hormone Antagonists; Humans; Male; Mutation; Paralyses, Familial Periodic; Sex Hormone-B | 2016 |
Resistance to Thyroid Hormone Alpha in an 18-Month-Old Girl: Clinical, Therapeutic, and Molecular Characteristics.
Topics: Cell Line; Child Development; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Hu | 2016 |
Thyroid hormone receptor beta gene mutation (P453A) in a family producing resistance to thyroid hormone.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Child; DNA Mutational Analysis; Female; Humans; Ma | 2009 |
Commentary: discordant measurements of serum triiodothyronine (T4), thyroxine (T3) and thyroid-stimulating hormone (TSH).
Topics: Antibodies, Heterophile; Attention Deficit Disorder with Hyperactivity; Female; Humans; Immunoassay; | 2008 |
Case report: thyroid hormone resistance and its therapeutic challenges.
Topics: Antithyroid Agents; Diagnosis, Differential; DNA Mutational Analysis; Female; Humans; Hyperthyroidis | 2008 |
Resistance to thyroid hormone in pregnancy.
Topics: Adult; Female; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Complications; Pregnancy Outcome; | 2008 |
Augmentation index in resistance to thyroid hormone (RTH).
Topics: Adult; Blood Glucose; Cardiovascular Diseases; Case-Control Studies; Cholesterol, LDL; Cohort Studie | 2009 |
[A 46-year-old patient with atrial fibrillation, elevated thyroid hormones and normal thyrotropine].
Topics: Atrial Fibrillation; Diagnosis, Differential; Humans; Male; Middle Aged; Thyroid Hormone Resistance | 2010 |
9 years follow-up of a patient with pituitary form of resistance to thyroid hormones (PRTH): comparison of two treatment periods of D-thyroxine and triiodothyroacetic acid (TRIAC).
Topics: Alkaline Phosphatase; Child; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Prenatal | 2009 |
Resistance to thyroid hormone in a patient with coexisting Graves' disease.
Topics: Graves Disease; Humans; Hypothyroidism; Male; Middle Aged; Thyroid Hormone Receptors beta; Thyroid H | 2010 |
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T).
Topics: Adult; Antithyroid Agents; Female; Graves Disease; Hashimoto Disease; Humans; Immunoglobulins, Thyro | 2010 |
Approach to the patient with resistance to thyroid hormone and pregnancy.
Topics: Adolescent; Female; Humans; Mutation; Pregnancy; Prenatal Diagnosis; Thyroid Hormone Receptors beta; | 2010 |
Novel mutation in MCT8 gene in a Brazilian boy with thyroid hormone resistance and severe neurologic abnormalities.
Topics: Amino Acid Sequence; Brain Diseases; Child; Humans; Male; Monocarboxylic Acid Transporters; Muscle H | 2011 |
Thyrotropin-lowering effect of metformin in a patient with resistance to thyroid hormone.
Topics: Adult; Diabetes Mellitus, Type 2; Humans; Hypothyroidism; Male; Metformin; Thyroid Hormone Resistanc | 2011 |
Differentiated thyroid cancer in two patients with resistance to thyroid hormone.
Topics: Carcinoma; Carcinoma, Papillary; Humans; Male; Middle Aged; Thyroid Cancer, Papillary; Thyroid Hormo | 2011 |
Thyroid hormone resistance caused by a novel deleterious variant of the thyroid hormone receptor beta gene.
Topics: Adult; Female; Humans; Infant; Infant, Newborn; Mutation, Missense; Thyroid Hormone Receptors beta; | 2013 |
A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone.
Topics: Animals; Animals, Newborn; Body Height; Bone and Bones; Bone Density; Bone Development; Craniosynost | 2003 |
Successful therapy with L-T4 in a 5 year-old boy with generalized thyroid hormone resistance.
Topics: Child, Preschool; Follow-Up Studies; Humans; Male; Receptors, Thyroid Hormone; Thyroid Hormone Resis | 2003 |
The novel missense mutation methionine 442 threonine in the thyroid hormone receptor beta causes thyroid hormone resistance: a case report.
Topics: Atrial Fibrillation; Goiter, Nodular; Humans; Male; Methionine; Middle Aged; Mutation, Missense; Ped | 2004 |
Fetal loss associated with excess thyroid hormone exposure.
Topics: Abortion, Spontaneous; Birth Weight; Female; Fetal Development; Fetal Diseases; Humans; Hyperthyroid | 2005 |
Resistance to thyroid hormone in a patient with thyroid dysgenesis.
Topics: Adolescent; Female; Humans; Hypothyroidism; Infant, Newborn; Lingual Goiter; Pedigree; Radionuclide | 2005 |
Mosaicism of a thyroid hormone receptor-beta gene mutation in resistance to thyroid hormone.
Topics: Adult; Base Sequence; DNA; Female; Humans; Male; Mosaicism; Pedigree; Polymerase Chain Reaction; Pol | 2006 |
Identification of TSH receptor mutations in three families with resistance to TSH.
Topics: Adolescent; Adult; Animals; Base Sequence; Child; Chlorocebus aethiops; COS Cells; Cyclic AMP; Femal | 2007 |
"They have ears but do not hear" (Psalms 135:17): non-thyroid hormone receptor beta (non-TRbeta) resistance to thyroid hormone.
Topics: Aging; Diagnosis, Differential; DNA, Complementary; Genetic Linkage; Humans; Mutation; Phenotype; Sy | 2008 |
A child with resistance to thyroid hormone without thyroid hormone receptor gene mutation: a 20-year follow-up.
Topics: Adult; Bone Density; DNA-Binding Proteins; Follow-Up Studies; Heart Rate; Histone Acetyltransferases | 2008 |
Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8.
Topics: Adolescent; Antithyroid Agents; Humans; Intellectual Disability; Male; Monocarboxylic Acid Transport | 2008 |
ADHD and thyroid abnormalities: a research note.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Diagnosis, Diffe | 1995 |
Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors?
Topics: Adolescent; Adult; Base Sequence; Binding, Competitive; Child; Child, Preschool; Female; Humans; Mal | 1995 |
Detection of resistance to thyroid hormone by cord blood screening.
Topics: Adult; Age Factors; Female; Fetal Blood; Follow-Up Studies; Humans; Infant; Infant, Newborn; Male; N | 1995 |
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study.
Topics: Adolescent; Adult; Aged; Base Sequence; Diagnosis, Differential; Female; Humans; Hyperthyroxinemia; | 1996 |
Evaluation of pituitary and peripheral tissue markers of thyroid hormone action in an Iranian family with resistance to thyroid hormone.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Ferritins; Humans; Iran; Male; Pedigree; | 1996 |
Difficulty in differentiating thyrotropin secreting pituitary microadenoma from pituitary-selective thyroid hormone resistance accompanied by pituitary incidentaloma.
Topics: Adenoma; Adult; Female; Gadolinium; Humans; Magnetic Resonance Imaging; Pituitary Neoplasms; Thyroid | 1996 |
Defective response of body height to growth hormone treatment in resistance to thyroid hormone with short stature.
Topics: Adolescent; Body Height; Drug Resistance; Female; Growth Disorders; Human Growth Hormone; Humans; In | 1996 |
Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity.
Topics: Animals; Cell Nucleus; DNA; Humans; Macromolecular Substances; Mutation; Pituitary Gland; Receptors, | 1997 |
[Thyroid hormone resistance: variable clinical manifestations in five patients].
Topics: Adult; Child; Female; Humans; Iodine Radioisotopes; Male; Middle Aged; Pedigree; Point Mutation; Rad | 1997 |
Reversible pituitary enlargement in the syndrome of resistance to thyroid hormone.
Topics: Female; Humans; Hyperthyroidism; Hypertrophy; Iodine Radioisotopes; Magnetic Resonance Imaging; Midd | 1998 |
Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin.
Topics: Animals; Disease Models, Animal; Mice; Mice, Transgenic; Mutation; Pituitary Gland; Protein Precurso | 1999 |
Prenatal diagnosis of thyroid hormone resistance.
Topics: Adult; DNA; Female; Fetal Blood; Fetal Diseases; Gestational Age; Heterozygote; Humans; Mutation; Pr | 1999 |
Association between an R338L mutation in the thyroid hormone receptor-beta gene and thyrotoxic features in two unrelated kindreds with resistance to thyroid hormone.
Topics: Adolescent; Aged; Alleles; Amino Acid Substitution; Arginine; Female; Follow-Up Studies; Haplotypes; | 1999 |
A novel resistance to thyroid hormone associated with a new mutation (T329N) in the thyroid hormone receptor beta gene.
Topics: Abortion, Habitual; Adult; Dextrothyroxine; Dimerization; Female; Humans; Male; Pedigree; Point Muta | 1999 |
Generalized resistance to thyroid hormones.
Topics: Adult; Body Height; Child; Child, Preschool; Consanguinity; Female; Human Growth Hormone; Humans; Hy | 1998 |
Altered thyroid hormone binding to plasma lipoproteins in the syndrome of resistance to thyroid hormones.
Topics: Cholesterol; Humans; Hypothyroidism; Lipid Metabolism; Lipoproteins; Syndrome; Thyroid Hormone Resis | 1999 |
Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor beta gene.
Topics: Adult; Child; Child, Preschool; Female; Genetic Linkage; Genotype; Haplotypes; Humans; Male; Mutatio | 1999 |
Quantitative assessment of pituitary resistance to thyroid hormone from plots of the logarithm of thyrotropin versus serum free thyroxine index.
Topics: Adult; Animals; DNA; Female; Humans; Leukocytes; Male; Middle Aged; Pituitary Gland; Rats; Receptors | 2000 |
Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse.
Topics: Animals; Energy Metabolism; Female; Mice; Phenotype; Pituitary Gland; Promoter Regions, Genetic; Rec | 2000 |
Resistance to thyroid hormone in a family with no TRbeta gene anomaly: pathogenic hypotheses.
Topics: Adult; Dinucleotide Repeats; Female; Genetic Linkage; Haplotypes; Humans; Mutation; Pedigree; Polymo | 2000 |
A case of familial euthyroid hyperthyroxinemia--thyroid hormone resistance syndrome?
Topics: Diagnosis, Differential; Female; Humans; Hyperthyroxinemia; India; Middle Aged; Pedigree; Thyroid Ho | 1999 |
Effects of thyroid hormones on cardiac structure: a tissue characterization study in patients with thyroid disorders before and after treatment.
Topics: Adult; Antithyroid Agents; Collagen; Echocardiography; Electrocardiography; Female; Humans; Hyperthy | 2001 |
Extreme thyroid hormone resistance in a patient with a novel truncated TR mutant.
Topics: Bone Development; Brain; Cells, Cultured; Female; Frameshift Mutation; Gene Deletion; Humans; Infant | 2001 |
Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4.
Topics: Adipose Tissue, Brown; Animals; Astrocytes; Blotting, Northern; Colforsin; Female; Hypothyroidism; I | 2001 |
Genetic analyses and evaluation of peripheral parameters of thyroid hormone action for the differential diagnosis of RTH. A novel heterozygous missense mutation (M334T) discovered.
Topics: Collagen Type I; Diagnosis, Differential; Female; Heterozygote; Humans; Magnetic Resonance Imaging; | 2002 |