Page last updated: 2024-11-06

thyroxine and Fetal Death

thyroxine has been researched along with Fetal Death in 24 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.

Research Excerpts

ExcerptRelevanceReference
" During pregnancy, the net intake of feed and water was not altered by the drug, but maternal serum thyroxine and metabolic rate were significantly elevated."7.68Diethylstilbestrol-induced perinatal lethality in the rat. I. Relationship to reduced maternal weight gain. ( Bradshaw, WS; Carter, MW; Clevenger, WR; Cornwall, GA, 1991)
"Pregnant A/WySn mice, 20 to 30% of whose offspring have spontaneous cleft lip, were treated with thyroxine."7.67Thyroxine-induced differential mortality of cleft lip mouse embryos: dose- and time-response studies of the A/WySn strain. ( Harris, MJ; Juriloff, DM, 1985)
"Recently, the recommended dose for iodine intake during pregnancy had been increased from 200 to 250 microg/day, because recent studies revealed that even mild-to-moderate iodine intake might affect the neuropsychological development of the child."4.85Thyroid diseases in pregnancy. ( Gärtner, R, 2009)
"Thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine, anti-thyroperoxidase antibody, and anti-thyroglobulin antibody at 11-13 weeks of gestation were measured in 202 singleton pregnancies that subsequently resulted in miscarriage or fetal death, and the values were compared with the results of 4318 normal pregnancies."3.76Maternal thyroid function at 11 to 13 weeks of gestation and subsequent fetal death. ( Ashoor, G; Jawdat, F; Maiz, N; Nicolaides, KH; Rotas, M, 2010)
"To examine the relationship between maternal TSH and free thyroxine (FT(4)) concentrations in early pregnancy and the risk of miscarriage, fetal or neonatal death."3.75Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death. ( Benhadi, N; Bonsel, GJ; Reitsma, JB; Vrijkotte, TG; Wiersinga, WM, 2009)
"Chronic exposure to high doses of iodine induces thyroid dysfunction, but effects of chronic exposure to high amounts of iodine on pregnancy and fetal outcome are uncertain."3.73Developmental toxic effects of chronic exposure to high doses of iodine in the mouse. ( Guo, HL; Hao, LP; Hou, XH; Liu, LG; Sun, XF; Xu, J; Yang, XF; Yao, P, 2006)
"5% or 3% respectively in the wet compounded diets) on plasma thyroxine (T4), reproductive performance and kit weight gain during lactation was investigated with 3 groups of each 20 mink females."3.69Plasma thyroxine concentration in non-pregnant and lactating mink, and effect of dietary rapeseed oil in the reproduction period. ( Neil, M; Tauson, AH, 1994)
" During pregnancy, the net intake of feed and water was not altered by the drug, but maternal serum thyroxine and metabolic rate were significantly elevated."3.68Diethylstilbestrol-induced perinatal lethality in the rat. I. Relationship to reduced maternal weight gain. ( Bradshaw, WS; Carter, MW; Clevenger, WR; Cornwall, GA, 1991)
"Pregnant A/WySn mice, 20 to 30% of whose offspring have spontaneous cleft lip, were treated with thyroxine."3.67Thyroxine-induced differential mortality of cleft lip mouse embryos: dose- and time-response studies of the A/WySn strain. ( Harris, MJ; Juriloff, DM, 1985)
"Pregnancy is a complex state with many endocrinological challenges to a woman's physiology."2.72Understanding the Pathogenesis of Gestational Hypothyroidism. ( Li, X; Mallawa Kankanamalage, O; Zhou, Q, 2021)
"Hypothyroidism is one of the most prevalent diseases in pregnancy, but there is no consensus about its management in pregnant women."2.58Pregnancy Complications Associated With Maternal Hypothyroidism: A Systematic Review. ( Aristides, SMA; de Carvalho, HC; Demarchi, IG; Günther, LSA; Lopes, LCB; Santos, TDS; Shinohara, DR; Teixeira, JJV, 2018)
"Although exposure to cyanogenic plants or cyanide during pregnancy has adverse effects, no teratological study with cyanide has been conducted in goats or any other ruminant."1.32Prenatal toxicity of cyanide in goats--a model for teratological studies in ruminants. ( Górniak, SL; Soto-Blanco, B, 2004)
"To examine the relation between certain pregnancy complications and thyroid stimulating hormone (TSH) measurements in a cohort of pregnant women."1.31Maternal thyroid deficiency and pregnancy complications: implications for population screening. ( Allan, WC; Faix, JD; Haddow, JE; Hermos, RJ; Klein, RZ; Mitchell, ML; Palomaki, GE; Williams, JR, 2000)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199012 (50.00)18.7374
1990's3 (12.50)18.2507
2000's5 (20.83)29.6817
2010's3 (12.50)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Mallawa Kankanamalage, O1
Zhou, Q1
Li, X1
Shinohara, DR1
Santos, TDS1
de Carvalho, HC1
Lopes, LCB1
Günther, LSA1
Aristides, SMA1
Teixeira, JJV1
Demarchi, IG1
Benhadi, N1
Wiersinga, WM1
Reitsma, JB1
Vrijkotte, TG1
Bonsel, GJ1
Gärtner, R1
Ashoor, G1
Maiz, N1
Rotas, M1
Jawdat, F1
Nicolaides, KH1
Willemsen, H1
Kamers, B1
Dahlke, F1
Han, H1
Song, Z1
Ansari Pirsaraei, Z1
Tona, K1
Decuypere, E1
Everaert, N1
SCHAEFER, W1
Soto-Blanco, B1
Górniak, SL1
Yang, XF1
Xu, J1
Hou, XH1
Guo, HL1
Hao, LP1
Yao, P1
Liu, LG1
Sun, XF1
Christie, GA1
Juriloff, DM2
Stowe, HD1
Rangel, F1
Anstead, C1
Goelling, B1
Tauson, AH1
Neil, M1
Smyth, JA1
Goodall, EA1
McCoy, MA1
Ellis, WA1
Allan, WC1
Haddow, JE1
Palomaki, GE1
Williams, JR1
Mitchell, ML1
Hermos, RJ1
Faix, JD1
Klein, RZ1
Mujtaba, Q1
Burrow, GN1
Pharoah, PO1
Ellis, SM1
Ekins, RP1
Williams, ES1
Clevenger, WR1
Cornwall, GA1
Carter, MW1
Bradshaw, WS1
Blackwell, TE1
Werdin, RE1
Eisenmenger, MC1
FitzSimmons, MA1
Davis, LE1
Leveno, KJ1
Cunningham, FG1
Harris, MJ1
Chew, PC1
Cheah, JS1
Chan, LK1
Tan, KL1
van Riet, HG1
Kal, J1
Haspels, AA1
Thwaites, CJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Are IQs Low in Offspring of Euthyroid Women With Low T4?[NCT00147433]5,000 participants Observational2004-02-29Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for thyroxine and Fetal Death

ArticleYear
Understanding the Pathogenesis of Gestational Hypothyroidism.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Abortion, Spontaneous; Abruptio Placentae; Animals; Estrogens; Female; Fetal Death; Humans; Hypothyr

2021
Pregnancy Complications Associated With Maternal Hypothyroidism: A Systematic Review.
    Obstetrical & gynecological survey, 2018, Volume: 73, Issue:4

    Topics: Abortion, Spontaneous; Female; Fetal Death; Humans; Hypothyroidism; Infant, Newborn; Maternal-Fetal

2018
Thyroid diseases in pregnancy.
    Current opinion in obstetrics & gynecology, 2009, Volume: 21, Issue:6

    Topics: Brain; Female; Fetal Death; Fetal Diseases; Hormone Replacement Therapy; Humans; Intelligence Tests;

2009
THE USE OF THIOURACIL DERIVATIVES DURING PREGNANCY: A REVIEW.
    Marquette medical review, 1964, Volume: 30

    Topics: Basal Metabolism; Female; Fetal Death; Goiter; Humans; Hyperthyroidism; Infant; Infant Mortality; In

1964
[Diabetes and pregnancy].
    Nederlands tijdschrift voor geneeskunde, 1974, Jan-26, Volume: 118, Issue:4

    Topics: Abortion, Spontaneous; Congenital Abnormalities; Estrogens; Female; Fetal Death; Growth Hormone; Hum

1974

Trials

1 trial available for thyroxine and Fetal Death

ArticleYear
Hyperthyroidism in pregnancy: a study of 37 pregnancies in 34 patients.
    Singapore medical journal, 1973, Volume: 14, Issue:2

    Topics: Adolescent; Adult; Antithyroid Agents; Birth Weight; Female; Fetal Death; Humans; Hypertension; Hype

1973

Other Studies

18 other studies available for thyroxine and Fetal Death

ArticleYear
Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death.
    European journal of endocrinology, 2009, Volume: 160, Issue:6

    Topics: Abortion, Spontaneous; Adult; Enzyme-Linked Immunosorbent Assay; Female; Fetal Death; Humans; Infant

2009
Maternal thyroid function at 11 to 13 weeks of gestation and subsequent fetal death.
    Thyroid : official journal of the American Thyroid Association, 2010, Volume: 20, Issue:9

    Topics: Abortion, Spontaneous; Adult; Autoantibodies; Female; Fetal Death; Humans; Hypertension; Hypothyroid

2010
High- and low-temperature manipulation during late incubation: effects on embryonic development, the hatching process, and metabolism in broilers.
    Poultry science, 2010, Volume: 89, Issue:12

    Topics: Animals; Body Temperature; Carbon Dioxide; Chick Embryo; Cold Temperature; Egg Shell; Eggs; Embryoni

2010
Prenatal toxicity of cyanide in goats--a model for teratological studies in ruminants.
    Theriogenology, 2004, Sep-15, Volume: 62, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Goats; Male; Models, Animal; Potassium Cy

2004
Developmental toxic effects of chronic exposure to high doses of iodine in the mouse.
    Reproductive toxicology (Elmsford, N.Y.), 2006, Volume: 22, Issue:4

    Topics: Animals; Colloids; Dose-Response Relationship, Drug; Eating; Female; Fetal Death; Fetal Development;

2006
Influence of thyroid function on the teratogenic activity of trypan blue in the rat.
    Journal of anatomy, 1966, Volume: 100, Issue:Pt 2

    Topics: Abnormalities, Drug-Induced; Animals; Basal Metabolism; Female; Fetal Death; Pregnancy; Pregnancy, A

1966
Thyroxin-induced differential mortality of mouse embryos with cleft lip.
    Developmental pharmacology and therapeutics, 1981, Volume: 2, Issue:1

    Topics: Animals; Cleft Lip; Dose-Response Relationship, Drug; Female; Fetal Death; Gestational Age; Male; Mi

1981
Influence of supplemental dietary vitamin A on the reproductive performance of iodine-toxic rats.
    The Journal of nutrition, 1980, Volume: 110, Issue:10

    Topics: Animals; Birth Weight; Dose-Response Relationship, Drug; Female; Fetal Death; Iodine; Litter Size; P

1980
Plasma thyroxine concentration in non-pregnant and lactating mink, and effect of dietary rapeseed oil in the reproduction period.
    Archiv fur Tierernahrung, 1994, Volume: 46, Issue:1

    Topics: Abortion, Veterinary; Animal Feed; Animals; Animals, Newborn; Body Weight; Brassica; Fatty Acids, Mo

1994
Stillbirth/perinatal weak calf syndrome: a study of calves with an abnormal thyroid gland.
    The Veterinary record, 1996, Jul-06, Volume: 139, Issue:1

    Topics: Animals; Body Weight; Cattle; Cattle Diseases; Female; Fetal Death; Organ Size; Parity; Pregnancy; S

1996
Maternal thyroid deficiency and pregnancy complications: implications for population screening.
    Journal of medical screening, 2000, Volume: 7, Issue:3

    Topics: Adult; Cohort Studies; Confidence Intervals; Delivery, Obstetric; Female; Fetal Death; Gestational A

2000
Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole.
    Obstetrics and gynecology, 1975, Volume: 46, Issue:3

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Female; Fetal Blood; Fetal Death; Goiter;

1975
Maternal thyroid function, iodine deficiency and fetal development.
    Clinical endocrinology, 1976, Volume: 5, Issue:2

    Topics: Child, Preschool; Congenital Hypothyroidism; Female; Fetal Death; Humans; Infant; Infant Mortality;

1976
Diethylstilbestrol-induced perinatal lethality in the rat. I. Relationship to reduced maternal weight gain.
    Biology of reproduction, 1991, Volume: 44, Issue:4

    Topics: Animals; Animals, Newborn; Diethylstilbestrol; Female; Fetal Death; Male; Maternal-Fetal Exchange; P

1991
Goitrogenic effects in offspring of swine fed sulfadimethoxine and ormetoprim in late gestation.
    Journal of the American Veterinary Medical Association, 1989, Feb-15, Volume: 194, Issue:4

    Topics: Animal Feed; Animals; Animals, Newborn; Female; Fetal Death; Goiter; Pregnancy; Pyrimidines; Sulfadi

1989
Hypothyroidism complicating pregnancy.
    Obstetrics and gynecology, 1988, Volume: 72, Issue:1

    Topics: Female; Fetal Death; Humans; Hypothyroidism; Infant, Newborn; Pregnancy; Pregnancy Complications; Pr

1988
Thyroxine-induced differential mortality of cleft lip mouse embryos: dose- and time-response studies of the A/WySn strain.
    Teratology, 1985, Volume: 31, Issue:3

    Topics: Animals; Cleft Lip; Dose-Response Relationship, Drug; Female; Fetal Death; Gestational Age; Mice; Mi

1985
Embryo mortality in the heat stressed ewe. 3. The role of the corpus luteum, thyroid and adrenal glands.
    Journal of reproduction and fertility, 1970, Volume: 21, Issue:1

    Topics: Adrenal Glands; Animals; Corpus Luteum; Female; Fetal Death; Hot Temperature; Hydrocortisone; Organ

1970