thyroxine has been researched along with Fatty Liver in 29 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance." | 4.02 | Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults. ( Chen, Y; Huang, B; Li, Z; Lin, M; Liu, C; Ma, D; Xiao, F; Yan, F; Ye, J; Zeng, J; Zeng, X; Zheng, X, 2021) |
| "Prevalence of dyslipidemia is high in obese children, and hypertriglyceridemia is in the foreground." | 1.42 | Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents. ( Demirel, F; Elmaoğulları, S; Karaca Kara, F; Tepe, D; Uçaktürk, SA, 2015) |
| "NAFLD was diagnosed by conventional ultrasound examination." | 1.40 | Thyroid hormone levels in obese children and adolescents with non-alcoholic fatty liver disease. ( Aydın, S; Cesur, Y; Gökçe, S; Özgen, IT; Torun, E, 2014) |
| "Hypothyroidism is closely associated with NAFLD independently of known metabolic risk factors, confirming a relevant clinical relationship between these two diseases." | 1.38 | Non-alcoholic fatty liver disease across the spectrum of hypothyroidism. ( Chung, GE; Kim, D; Kim, W; Kim, YJ; Lee, HS; Park, MJ; Yim, JY; Yoon, JH, 2012) |
| "Patients with NAFLD had significantly lower levels of serum-free thyroxine (FT4) than controls (11·12 ± 1·43 vs 11·58 ± 1·47 pmol/l; P < 0·001)." | 1.37 | Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese. ( Li, Y; Miao, M; Xu, C; Xu, L; Yu, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (44.83) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, D | 1 |
| Zeng, J | 1 |
| Huang, B | 1 |
| Yan, F | 1 |
| Ye, J | 1 |
| Chen, Y | 1 |
| Zeng, X | 1 |
| Zheng, X | 1 |
| Xiao, F | 1 |
| Lin, M | 1 |
| Liu, C | 1 |
| Li, Z | 1 |
| Merchan-Ramirez, E | 1 |
| Sanchez-Delgado, G | 1 |
| Arrizabalaga-Arriazu, C | 1 |
| Acosta, FM | 1 |
| Arias-Tellez, MJ | 1 |
| Muñoz-Torres, M | 1 |
| Garcia-Lario, JV | 1 |
| Llamas-Elvira, JM | 1 |
| Ruiz, JR | 1 |
| Cortés, VA | 1 |
| Cautivo, KM | 1 |
| Rong, S | 1 |
| Garg, A | 1 |
| Horton, JD | 1 |
| Agarwal, AK | 1 |
| Torun, E | 1 |
| Özgen, IT | 1 |
| Gökçe, S | 1 |
| Aydın, S | 1 |
| Cesur, Y | 1 |
| Liu, X | 1 |
| Wang, S | 1 |
| You, Y | 1 |
| Meng, M | 1 |
| Zheng, Z | 1 |
| Dong, M | 1 |
| Lin, J | 1 |
| Zhao, Q | 1 |
| Zhang, C | 1 |
| Yuan, X | 1 |
| Hu, T | 1 |
| Liu, L | 1 |
| Huang, Y | 1 |
| Zhang, L | 1 |
| Wang, D | 1 |
| Zhan, J | 1 |
| Jong Lee, H | 1 |
| Speakman, JR | 1 |
| Jin, W | 1 |
| Elmaoğulları, S | 1 |
| Tepe, D | 1 |
| Uçaktürk, SA | 1 |
| Karaca Kara, F | 1 |
| Demirel, F | 1 |
| Geach, T | 1 |
| Ellett, JD | 1 |
| Evans, ZP | 1 |
| Fiorini, JH | 1 |
| Fiorini, RN | 1 |
| Haines, JK | 1 |
| Schmidt, MG | 1 |
| Chavin, KD | 1 |
| Novitzky, D | 1 |
| Cooper, DK | 1 |
| Wicomb, W | 1 |
| Xu, C | 1 |
| Xu, L | 1 |
| Yu, C | 1 |
| Miao, M | 1 |
| Li, Y | 1 |
| Walsh, JP | 1 |
| Chung, GE | 1 |
| Kim, D | 1 |
| Kim, W | 1 |
| Yim, JY | 1 |
| Park, MJ | 1 |
| Kim, YJ | 1 |
| Yoon, JH | 1 |
| Lee, HS | 1 |
| Ittermann, T | 1 |
| Haring, R | 1 |
| Wallaschofski, H | 1 |
| Baumeister, SE | 1 |
| Nauck, M | 1 |
| Dörr, M | 1 |
| Lerch, MM | 1 |
| Lerch, M | 1 |
| Meyer zu Schwabedissen, HE | 1 |
| Rosskopf, D | 1 |
| Völzke, H | 1 |
| Choh, NA | 1 |
| INFANTE, R | 3 |
| CALDARERA, CM | 1 |
| TURCHETTO, E | 2 |
| Frangioni, G | 1 |
| Atzori, A | 1 |
| Balzi, M | 1 |
| Fuzzi, G | 1 |
| Ghinassi, A | 1 |
| Pescosolido, N | 1 |
| Bianchi, S | 1 |
| Borgioli, G | 1 |
| Akiba, Y | 2 |
| Takahashi, K | 1 |
| Kimura, M | 1 |
| Hirama, SI | 1 |
| Matsumoto, T | 1 |
| Jensen, LS | 1 |
| Barb, CR | 1 |
| Kraeling, RR | 1 |
| Takano, S | 1 |
| Kanzaki, S | 1 |
| Sato, M | 1 |
| Kubo, T | 1 |
| Seino, Y | 1 |
| Robertson, DA | 1 |
| Wright, R | 1 |
| Krüskemper, HL | 1 |
| Morgner, KD | 1 |
| Hamuro, Y | 1 |
| Westerfeld, WW | 2 |
| Elwood, JC | 2 |
| Richert, DA | 2 |
| Noda, K | 1 |
| Ylikahri, RH | 1 |
| Bergman, F | 1 |
| van der Linden, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Activating Brown Adipose Tissue Through Exercise: Randomized Controlled Trial[NCT02365129] | 180 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | |||
| Effects of 4-month Therapy of Levothyroxine on Non-Alcoholic Fatty Liver Disease (NAFLD) and Diabetes Control in Diabetic Patients[NCT03281083] | Phase 2 | 29 participants (Actual) | Interventional | 2014-03-28 | Terminated (stopped due to Difficult recruitment and end of funding.) | ||
| Early Predictors of NAFLD in Patient of Hypothyroidism[NCT05813301] | 100 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
29 other studies available for thyroxine and Fatty Liver
| Article | Year |
|---|---|
Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults.
Topics: Adult; China; Cross-Sectional Studies; Fatty Liver; Humans; Insulin Resistance; Obesity; Overweight; | 2021 |
Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults.
Topics: Adiposity; Body Mass Index; Cardiometabolic Risk Factors; Cross-Sectional Studies; Fatty Liver; Fema | 2022 |
Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.
Topics: 1-Acylglycerol-3-Phosphate O-Acyltransferase; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcr | 2014 |
Thyroid hormone levels in obese children and adolescents with non-alcoholic fatty liver disease.
Topics: Adolescent; Anthropometry; Biomarkers; Case-Control Studies; Child; Fatty Liver; Female; Follow-Up S | 2014 |
Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice.
Topics: Adiponectin; Adipose Tissue; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Energy Metabolis | 2015 |
Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents.
Topics: Adolescent; Alanine Transaminase; Analysis of Variance; Aspartate Aminotransferases; Blood Glucose; | 2015 |
Thyroid function: Poor thyroid function linked to NAFLD.
Topics: Fatty Liver; Humans; Non-alcoholic Fatty Liver Disease; Thyroid Function Tests; Thyroid Gland; Thyro | 2016 |
The use of the Papworth cocktail is detrimental to steatotic livers after ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Alanine Transaminase; Animals; Fatty Liver; Liver; Liver Transplantation; Ma | 2008 |
Hormonal therapy to the brain-dead potential organ donor: the misnomer of the "Papworth cocktail".
Topics: Brain Death; Drug Therapy, Combination; Fatty Liver; Hormones; Humans; Liver; Methylprednisolone; Te | 2008 |
Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese.
Topics: Aged; Asian People; Body Mass Index; Cross-Sectional Studies; Fatty Liver; Humans; Non-alcoholic Fat | 2011 |
Setpoints and susceptibility: do small differences in thyroid function really matter?
Topics: Fatty Liver; Humans; Non-alcoholic Fatty Liver Disease; Thyroid Gland; Thyroxine | 2011 |
Non-alcoholic fatty liver disease across the spectrum of hypothyroidism.
Topics: Adult; Alanine Transaminase; Body Mass Index; Cross-Sectional Studies; Fatty Liver; Female; Humans; | 2012 |
Inverse association between serum free thyroxine levels and hepatic steatosis: results from the Study of Health in Pomerania.
Topics: Adult; Aged; Alanine Transaminase; Cross-Sectional Studies; Fatty Liver; Female; Germany; Humans; Li | 2012 |
Hepatic subcapsular steatosis: a rare complication of high dose insulin therapy.
Topics: Adolescent; Diabetes Complications; Dose-Response Relationship, Drug; Fatty Liver; Female; Humans; H | 2012 |
[Hepatic desoxyribonucleic acid & ribonucleic acid in the rat on steatogenous diet & treated with vitamin B12 & thyroxin].
Topics: Animals; Diet; DNA; Fatty Liver; Nucleic Acids; Rats; RNA; Thyroxine; Vitamin B 12 | 1958 |
[Antisteatotic effect of several lipotropic drugs associated with thyroxin: influence of sex].
Topics: Fatty Liver; Humans; Lipotropic Agents; Sex Characteristics; Thyroxine | 1958 |
[Behavior of hepatic glycogen in the rat on steatogenous diet & after antisteatotic treatment].
Topics: Animals; Diet; Fatty Liver; Glycogen; Glycogenolysis; Lipotropic Agents; Liver Glycogen; Rats; Thyro | 1958 |
Thyroid and hypoxic stress in the newt Triturus carnifex.
Topics: Animals; Fatty Liver; Female; Heart Rate; Histocytochemistry; Hypoxia; Kidney; Male; Melanosis; Pitu | 2006 |
The influence of environmental temperature, thyroid status and a synthetic oestrogen on the induction of fatty livers in chicks.
Topics: Animals; Chickens; Dienestrol; Estradiol Congeners; Fatty Liver; Lipid Metabolism; Liver; Male; Poul | 1983 |
Plasma estradiol, thyroid hormones, and liver lipid content in laying hens fed different isocaloric diets.
Topics: Animals; Chickens; Diet; Energy Intake; Estradiol; Fatty Liver; Female; Fish Products; Lipids; Liver | 1982 |
Effect of growth hormone on fatty liver in panhypopituitarism.
Topics: Adolescent; Anti-Inflammatory Agents; Fatty Liver; Growth Disorders; Growth Hormone; Humans; Hydroco | 1997 |
Cirrhosis in partial lipodystrophy.
Topics: Adult; Autoimmune Diseases; Fatty Liver; Female; Humans; Hypothyroidism; Lipodystrophy; Liver Cirrho | 1989 |
[Protein-bound iodine and D-thyroxine turnover in liver diseases].
Topics: Acute Disease; Blood Proteins; Cholestasis; Chronic Disease; Diabetes Complications; Diagnosis, Diff | 1969 |
Effect of adrenal and hypophyseal hormones on the development of fatty liver in rats fed orotic acid.
Topics: Administration, Oral; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Fatty Liv | 1972 |
Effect of clofibrate on the handling of dietary and liver fat.
Topics: Animals; Cholesterol; Clofibrate; Diet; Electrophoresis, Disc; Enzyme Activation; Fatty Liver; Gluco | 1972 |
A comparison of hypolipidemic drugs in the prevention of an orotic acid fatty liver.
Topics: Animals; Clofibrate; Diet; Electrophoresis; Ethylamines; Fatty Liver; Glucosephosphate Dehydrogenase | 1972 |
Influence of insulin, hydrocortisone and thyroxine on fatty liver of rats fed a low casein diet supplemented with methionine.
Topics: Adrenal Glands; Adrenalectomy; Animal Nutritional Physiological Phenomena; Animals; Blood Proteins; | 1971 |
Ethanol-induced changes in hepatic alpha-glycerophosphate and triglyceride concentrations in normal and thyroxine-treated rats.
Topics: Acetone; Animals; Body Weight; Ethanol; Fatty Acids, Nonesterified; Fatty Liver; Glycerophosphates; | 1970 |
Further studies on the influence of thyroxine on gallstone formation in hamsters.
Topics: Animals; Cholelithiasis; Cholesterol; Cricetinae; Diet; Fatty Liver; Female; Insulin; Liver; Male; P | 1966 |