thyroxine has been researched along with Familial Precocious Puberty in 46 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " She was diagnosed with autoimmune thyroiditis and was started on replacement therapy with thyroxine, after which the ovarian cysts regressed." | 3.88 | Van Wyk Grumbach Syndrome: A Rare Consequence of Hypothyroidism. ( Khubchandani, R; Kulkarni, A; Parikh, K; Reddy, P; Tiwari, K, 2018) |
| "Prompt and adequate medical management with levothyroxine can completely reverse ovarian enlargement associated with hypothyroidism." | 3.81 | Asymmetrical Ovarian Enlargement: Caught Timely Before the Cut! ( Bhagwat, NM; Dalwadi, PP; Joshi, AS; Pawal, PS; Varthakavi, PK, 2015) |
| " At the end of the first year of clinical follow-up, secondary hypothyroidism was detected and L-thyroxine was added to the treatment." | 3.80 | Acceleration of puberty during growth hormone therapy in a child with septo-optic dysplasia. ( Abacı, A; Altıncık, A; Anık, A; Böber, E; Catlı, G; Demir, K; Güleryüz, H, 2014) |
| "To describe 2 cases of primary hypothyroidism, precocious puberty, large multicystic ovaries, possible diagnostic dilemma, unilateral oophorectomies, and subsequent response to levothyroxine replacement therapy." | 3.74 | Precocious puberty and large multicystic ovaries in young girls with primary hypothyroidism. ( Deepak, T; Sanjay, S; Sanjeevaiah, AR; Sharada, A; Srikanta, SS, 2007) |
| "Van Wyk-Grumbach syndrome is a rare disease characterized by precocious puberty associated with prolonged hypothyroidism and multicystic enlarged ovaries." | 2.48 | Unusual presentations of a girl with Down syndrome: Van Wyk-Grumbach syndrome. ( Kil, HR; Kim, JY; Lim, HH, 2012) |
| "The syndrome consisting of primary hypothyroidism, precocious puberty, and massive ovarian cysts was termed Van Wyk and Grumbach syndrome in 1960." | 2.47 | Van wyk and grumbach syndrome: an unusual case and review of the literature. ( Diaz-Montes, T; Durbin, KL; Loveless, MB, 2011) |
| "Precocious puberty is defined when secondary sexual characteristics develop before the age of eight for girls and nine for boys." | 1.56 | Serum Levels of Thyroid Stimulating Hormone and Luteinizing Hormone Are Decreased in Girls with Central Precocious Puberty after 12-Month GnRH Agonist Treatment. ( Chung, LY; Kang, E; Kim, YJ; Lee, KH; Nam, HK; Rhie, YJ, 2020) |
| "Precocious puberty is characterised by premature appearance of secondary sexual characteristics before the age of 7 years in girls and 9 years in boys." | 1.48 | Dandy-Walker variant with precocious puberty: a rare association. ( Ahlawat, P; Mishra, S; Rajput, R; Yadav, PK, 2018) |
| "This rare syndrome is easy to be misdiagnosed as pituitary and ovarian tumor." | 1.43 | [Van Wyk-Grumbach syndrome: A case report and literature review]. ( Jin, P; Mo, Z; Xie, Y; Yang, F; Zhang, Q, 2016) |
| "Clinically this syndrome is a diagnostic challenge because hypothyroidism usually leads to pubertal and growth delay, whereas in case of VWGS hypothyroidism it leads to growth delay and precocious puberty." | 1.40 | Van Wyk and Grumbach syndrome: an unusual form of precocious puberty. ( Bullens, D; Casteels, K; Christens, A; Sevenants, L; Toelen, J, 2014) |
| "A case of primary hypothyroidism in a pre-pubertal girl presenting with vaginal bleeding and unilateral ovarian cyst is reported." | 1.33 | Ovarian cyst in juvenile hypothyroidism. ( Ammini, AC; Kriplani, A; Singh, BM, 2005) |
| "The cysts and precocious puberty resolved spontaneously after the simple replacement of thyroid hormone." | 1.33 | Primary hypothyroidism presenting as ovarian tumor and precocious puberty in a prepubertal girl. ( Aoki, T; Beznos, GW; Campaner, AB; Dos Santos, RE; Machado, RO; Scapinelli, A, 2006) |
| "Ovarian cysts have been reported in girls with longstanding uncompensated primary hypothyroidism." | 1.33 | Ovarian cysts in young girls with hypothyroidism: follow-up and effect of treatment. ( Bajpai, A; Kabra, M; Menon, PS; Mittal, S; Sharma, Y, 2006) |
| "We describe a case of acquired primary hypothyroidism in a prepubertal girl who presented with profound bradycardia, precocious puberty, and severe vaginal bleeding." | 1.30 | Primary hypothyroidism presenting as severe vaginal bleeding in a prepubertal girl. ( Austin, DJ; Gordon, CM; Laufer, MR; Radovick, S, 1997) |
| "The diagnosis of primary hypothyroidism was made late because of misleading results of protein bound iodine estimations." | 1.26 | Precocious puberty associated with primary hypothyroidism in a mongol girl. ( Chapman, C; Hancock, KW; Stitch, SR, 1979) |
| " Following low dosage cyproterone acetate (CA) therapy (mean daily dosage 65 mg/m2BSA) a beneficial effect on growth and skeletal maturation was observed." | 1.26 | Effect of cyproterone acetate (CA) on growth and endocrine function in precocious puberty. ( Ilicki, A; Stahnke, N; Willig, RP, 1979) |
| "Evidence is presented that precocious puberty in juvenile hypothyroidism may be the result of PRL hypersecretion." | 1.26 | Precocious puberty in juvenile hypothyroidism. ( Hemady, ZS; Najjar, S; Siler-Khodr, TM, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (30.43) | 18.7374 |
| 1990's | 2 (4.35) | 18.2507 |
| 2000's | 13 (28.26) | 29.6817 |
| 2010's | 13 (28.26) | 24.3611 |
| 2020's | 4 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Singhania, P | 1 |
| Bhattarcharjee, R | 1 |
| Chowdhury, S | 1 |
| Kandasamy, D | 3 |
| Malik, R | 3 |
| Sharma, R | 3 |
| Jana, M | 3 |
| Naderi, F | 1 |
| Soheilirad, Z | 1 |
| Haghshenas, Z | 1 |
| Kim, YJ | 1 |
| Chung, LY | 1 |
| Kang, E | 1 |
| Nam, HK | 1 |
| Rhie, YJ | 1 |
| Lee, KH | 1 |
| Riaz, M | 1 |
| Ibrahim, MN | 1 |
| Laghari, TM | 1 |
| Hanif, MI | 1 |
| Raza, J | 1 |
| Chanda, PK | 1 |
| Kamrul-Hasan, M | 1 |
| Abu-Bakar, M | 1 |
| Rahman, M | 1 |
| Kader, MA | 1 |
| Hossain, MA | 1 |
| Siddiqui, NI | 1 |
| Reddy, P | 1 |
| Tiwari, K | 1 |
| Kulkarni, A | 1 |
| Parikh, K | 1 |
| Khubchandani, R | 1 |
| Rajput, R | 1 |
| Mishra, S | 1 |
| Ahlawat, P | 1 |
| Yadav, PK | 1 |
| Zhang, H | 1 |
| Geng, N | 1 |
| Wang, Y | 1 |
| Tian, W | 1 |
| Xue, F | 1 |
| Christens, A | 1 |
| Sevenants, L | 1 |
| Toelen, J | 1 |
| Bullens, D | 1 |
| Casteels, K | 1 |
| Catlı, G | 1 |
| Altıncık, A | 1 |
| Anık, A | 1 |
| Demir, K | 1 |
| Güleryüz, H | 1 |
| Abacı, A | 1 |
| Böber, E | 1 |
| Bas, S | 1 |
| Guran, T | 1 |
| Atay, Z | 1 |
| Haliloglu, B | 1 |
| Abalı, S | 1 |
| Turan, S | 1 |
| Bereket, A | 1 |
| Bhagwat, NM | 1 |
| Dalwadi, PP | 1 |
| Joshi, AS | 1 |
| Pawal, PS | 1 |
| Varthakavi, PK | 1 |
| Oden Akman, A | 1 |
| Tayfun, M | 1 |
| Demirel, F | 1 |
| Ucakturk, SA | 1 |
| Gungor, A | 1 |
| Jin, P | 1 |
| Zhang, Q | 1 |
| Mo, Z | 1 |
| Yang, F | 1 |
| Xie, Y | 1 |
| Bulugahapitiya, DT | 1 |
| Kumar, KV | 1 |
| Muthukrishnan, J | 1 |
| Sinha, R | 1 |
| Modi, KD | 1 |
| Karthikeyan, A | 1 |
| Agwu, JC | 1 |
| Durbin, KL | 1 |
| Diaz-Montes, T | 1 |
| Loveless, MB | 1 |
| Lim, HH | 1 |
| Kil, HR | 1 |
| Kim, JY | 1 |
| PLANTIER, HA | 1 |
| HUBBLE, D | 1 |
| DEMOWBRAY, RR | 1 |
| Chattopadhyay, A | 1 |
| Kumar, V | 1 |
| Marulaiah, M | 1 |
| Singh, BM | 1 |
| Ammini, AC | 1 |
| Kriplani, A | 1 |
| Campaner, AB | 1 |
| Scapinelli, A | 1 |
| Machado, RO | 1 |
| Dos Santos, RE | 1 |
| Beznos, GW | 1 |
| Aoki, T | 1 |
| Sharma, Y | 1 |
| Bajpai, A | 1 |
| Mittal, S | 1 |
| Kabra, M | 1 |
| Menon, PS | 1 |
| Mohsin, F | 1 |
| Nahar, N | 1 |
| Azad, K | 1 |
| Nahar, J | 1 |
| Sanjeevaiah, AR | 1 |
| Sanjay, S | 1 |
| Deepak, T | 1 |
| Sharada, A | 1 |
| Srikanta, SS | 1 |
| Evers, JL | 1 |
| Rolland, R | 1 |
| Gordon, CM | 1 |
| Austin, DJ | 1 |
| Radovick, S | 1 |
| Laufer, MR | 1 |
| Bhansali, A | 1 |
| Kashyap, A | 1 |
| Lodha, S | 1 |
| Kotwal, N | 1 |
| Ganapathi, B | 1 |
| Mittal, BR | 1 |
| Dash, RJ | 1 |
| Miyazaki, R | 1 |
| Yanagawa, N | 1 |
| Higashino, H | 1 |
| Kobayashi, Y | 1 |
| Asami, T | 1 |
| Kikuchi, T | 1 |
| Kamimura, T | 1 |
| Kinoshita, S | 1 |
| Uchiyama, M | 1 |
| Dhanwal, D | 1 |
| Tandon, N | 1 |
| Hancock, KW | 1 |
| Stitch, SR | 1 |
| Chapman, C | 1 |
| Stahnke, N | 1 |
| Ilicki, A | 1 |
| Willig, RP | 1 |
| Hemady, ZS | 1 |
| Siler-Khodr, TM | 1 |
| Najjar, S | 1 |
| Romshe, CA | 1 |
| Sotos, JF | 1 |
| Bhattacharya, M | 1 |
| Mitra, AK | 1 |
| Chitkara, AJ | 1 |
| Singh, JP | 1 |
| Khalil, A | 1 |
| Mittal, SK | 1 |
| Sharma, D | 1 |
| De Luca, F | 1 |
| Smedile, G | 1 |
| Arrigo, T | 1 |
| Pandullo, E | 1 |
| Muritano, M | 1 |
| Arcoraci, A | 1 |
| Tönz, O | 1 |
| Trost, P | 1 |
| Lee, PA | 1 |
| Blizzard, RM | 1 |
| Laron, Z | 1 |
| Karp, M | 1 |
| Dolberg, L | 1 |
4 reviews available for thyroxine and Familial Precocious Puberty
| Article | Year |
|---|---|
Van Wyk and Grumbach syndrome: two case reports and review of the published work.
Topics: Child; Female; Humans; Hypothyroidism; Ovarian Cysts; Pituitary Neoplasms; Prolactinoma; Puberty, Pr | 2014 |
Van wyk and grumbach syndrome: an unusual case and review of the literature.
Topics: Abdominal Pain; Adenoma; Biomarkers, Tumor; Child; Female; Humans; Hypothyroidism; Magnetic Resonanc | 2011 |
Unusual presentations of a girl with Down syndrome: Van Wyk-Grumbach syndrome.
Topics: Abnormalities, Multiple; Child; Down Syndrome; Female; Humans; Hypothyroidism; Ovarian Cysts; Pubert | 2012 |
Precocious puberty in a girl with congenital hypothyroidism receiving continuous L-thyroxine-replacement therapy.
Topics: Child, Preschool; Congenital Hypothyroidism; Female; Gonadal Steroid Hormones; Humans; Hypothyroidis | 2001 |
42 other studies available for thyroxine and Familial Precocious Puberty
| Article | Year |
|---|---|
Van Wyk-Grumbach syndrome: a rare presentation of a common endocrine disorder.
Topics: Endocrine System Diseases; Female; Humans; Hypothyroidism; Ovarian Cysts; Puberty, Precocious; Syndr | 2022 |
Case 308: Van Wyk-Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovary; Puberty, Precocious; Syndrome; Thyroxine | 2022 |
Case 308: Van Wyk-Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovary; Puberty, Precocious; Syndrome; Thyroxine | 2022 |
Case 308: Van Wyk-Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovary; Puberty, Precocious; Syndrome; Thyroxine | 2022 |
Case 308: Van Wyk-Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovary; Puberty, Precocious; Syndrome; Thyroxine | 2022 |
Case 308: Van Wyk-Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovary; Puberty, Precocious; Syndrome; Thyroxine | 2022 |
Case 308: Van Wyk-Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovary; Puberty, Precocious; Syndrome; Thyroxine | 2022 |
Case 308: Van Wyk-Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovary; Puberty, Precocious; Syndrome; Thyroxine | 2022 |
Case 308: Van Wyk-Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovary; Puberty, Precocious; Syndrome; Thyroxine | 2022 |
Case 308: Van Wyk-Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovary; Puberty, Precocious; Syndrome; Thyroxine | 2022 |
The Influence of Gonadotropin-Releasing Hormone Agonist Treatment on Thyroid Function Tests in Children with Central Idiopathic Precocious Puberty.
Topics: Child; Cross-Sectional Studies; Female; Gonadotropin-Releasing Hormone; Humans; Hypothyroidism; Male | 2019 |
Serum Levels of Thyroid Stimulating Hormone and Luteinizing Hormone Are Decreased in Girls with Central Precocious Puberty after 12-Month GnRH Agonist Treatment.
Topics: Child; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hor | 2020 |
Van Wyk Grumbach Syndrome.
Topics: Child; Female; Humans; Hypothyroidism; Ovarian Cysts; Polycystic Ovary Syndrome; Puberty, Precocious | 2020 |
Van Wyk and Grumbach Syndrome: An Unusual Presentation of Hypothyroism.
Topics: Adolescent; Body Height; Female; Humans; Hypothyroidism; Ovarian Cysts; Puberty, Precocious; Syndrom | 2017 |
Van Wyk Grumbach Syndrome: A Rare Consequence of Hypothyroidism.
Topics: Child; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Intestinal Obstruction; Ovarian | 2018 |
Dandy-Walker variant with precocious puberty: a rare association.
Topics: Child; Cholecalciferol; Dandy-Walker Syndrome; Humans; Hypothyroidism; Male; Puberty, Precocious; Th | 2018 |
Van Wyk and Grumbach syndrome: an unusual form of precocious puberty.
Topics: Age Determination by Skeleton; Child; Female; Humans; Hypothyroidism; Puberty, Precocious; Syndrome; | 2014 |
Acceleration of puberty during growth hormone therapy in a child with septo-optic dysplasia.
Topics: Child; Female; Human Growth Hormone; Humans; Hypothyroidism; Puberty, Precocious; Recombinant Protei | 2014 |
Premature pubarche, hyperinsulinemia and hypothyroxinemia: novel manifestations of congenital portosystemic shunts (Abernethy malformation) in children.
Topics: Adolescent; Child; Female; Humans; Hyperinsulinism; Puberty, Precocious; Thyroxine; Vascular Malform | 2015 |
Asymmetrical Ovarian Enlargement: Caught Timely Before the Cut!
Topics: Abdominal Pain; Child; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Ovarian Cysts; P | 2015 |
Association of Van Wyk Grumbach and Debre Semelaigne Syndromes with Severe Hypothyroidism.
Topics: Adolescent; Congenital Hypothyroidism; Diagnosis, Differential; Female; Humans; Hypertrophy; Muscle, | 2015 |
[Van Wyk-Grumbach syndrome: A case report and
literature review].
Topics: Adolescent; Congenital Hypothyroidism; Diagnosis, Differential; Diagnostic Errors; Female; Humans; H | 2016 |
Precocious sexual development in an untreated cretin.
Topics: Child; Congenital Hypothyroidism; Female; Humans; Puberty, Precocious; Thyroxine | 1972 |
Two cases describing the effects of hypothyroidism on puberty and growth.
Topics: Child; Female; Growth Disorders; Hormone Replacement Therapy; Humans; Hypothyroidism; Puberty, Preco | 2008 |
Precocious puberty.
Topics: Child; Female; Humans; Hypothyroidism; Puberty, Precocious; Thyroxine | 2008 |
Epidemiology.
Topics: Child; Female; Humans; Hypothyroidism; Puberty, Precocious; Thyroxine | 2008 |
PRECOCIOUS PUBESCENCE--IATROGENIC.
Topics: Anabolic Agents; Ascorbic Acid; Child; Erythema Multiforme; Iatrogenic Disease; Methyltestosterone; | 1964 |
THE ENDOCRINE DISORDERS OF CHILDHOOD.
Topics: Adrenal Gland Diseases; Adrenogenital Syndrome; Child; Congenital Hypothyroidism; Disorders of Sex D | 1964 |
THE HORMONES AND PUBERTY.
Topics: Adolescent; Child; Chorionic Gonadotropin; Cryptorchidism; Diethylstilbestrol; Ethinyl Estradiol; Eu | 1964 |
Polycystic ovaries, precocious puberty and acquired hypothyroidism: The Van Wyk and Grumbach syndrome.
Topics: Child; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Polycystic Ovary Syndrome; Puber | 2003 |
Ovarian cyst in juvenile hypothyroidism.
Topics: Child; Female; Growth Disorders; Humans; Hypothyroidism; Ovarian Cysts; Puberty, Precocious; Thyroxi | 2005 |
Primary hypothyroidism presenting as ovarian tumor and precocious puberty in a prepubertal girl.
Topics: Child; Female; Humans; Hypothyroidism; Ovarian Cysts; Puberty, Precocious; Thyroid Gland; Thyroiditi | 2006 |
Ovarian cysts in young girls with hypothyroidism: follow-up and effect of treatment.
Topics: Child; Child, Preschool; Female; Follow-Up Studies; Humans; Hypothyroidism; Ovarian Cysts; Pituitary | 2006 |
Vaginal bleeding with multicystic ovaries and a pituitary mass in a child with severe hypothyroidism.
Topics: Child; Female; Humans; Hypothyroidism; Metrorrhagia; Pituitary Neoplasms; Polycystic Ovary Syndrome; | 2007 |
Precocious puberty and large multicystic ovaries in young girls with primary hypothyroidism.
Topics: Adolescent; Child, Preschool; Female; Humans; Hypothyroidism; Ovariectomy; Polycystic Ovary Syndrome | 2007 |
Primary hypothyroidism and ovarian activity evidence for an overlap in the synthesis of pituitary glycoproteins. Case report.
Topics: Adolescent; Female; Galactorrhea; Glycoproteins; Humans; Hypothyroidism; Ovarian Cysts; Pituitary Ho | 1981 |
Primary hypothyroidism presenting as severe vaginal bleeding in a prepubertal girl.
Topics: Bradycardia; Child; Diagnosis, Differential; Drainage; Estradiol; Female; Humans; Hypothyroidism; Ov | 1997 |
Isosexual precocity: uncommon presentation of a common disorder.
Topics: Child; Female; Follow-Up Studies; Humans; Hypothyroidism; Puberty, Precocious; Thyroxine | 2000 |
LHRH analogue and growth hormone did not improve the final height of a patient with juvenile hypothyroidism accompanied by precocious puberty.
Topics: Body Height; Child; Female; Gonadotropin-Releasing Hormone; Growth Hormone; Humans; Hypothyroidism; | 2000 |
Isolated menarche and multicystic ovaries in a 7 1/2 year girl with hypothyroidism.
Topics: Child; Female; Follow-Up Studies; Humans; Hypothyroidism; Menarche; Polycystic Ovary Syndrome; Puber | 2001 |
Precocious puberty associated with primary hypothyroidism in a mongol girl.
Topics: Child; Cyproterone; Down Syndrome; Female; Follicle Stimulating Hormone; Gonadotropins, Pituitary; H | 1979 |
Effect of cyproterone acetate (CA) on growth and endocrine function in precocious puberty.
Topics: Arginine; Body Height; Cyproterone; Glucose; Growth; Humans; Hydrocortisone; Insulin; Lypressin; Mal | 1979 |
Precocious puberty in juvenile hypothyroidism.
Topics: Adolescent; Child; Child, Preschool; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Human | 1978 |
Intracranial human chorionic gonadotropin-secreting tumor with precocious puberty.
Topics: 17-Ketosteroids; Cerebral Ventricle Neoplasms; Child; Choriocarcinoma; Chorionic Gonadotropin; Femal | 1975 |
Regression of precocious puberty in a child with hypothyroidism after thyroxine therapy.
Topics: Child; Developing Countries; Female; Humans; Hypothyroidism; India; Puberty, Precocious; Thyroxine | 1992 |
Sexual precocity in primary hypothyroidism.
Topics: Child; Child, Preschool; Female; Humans; Hypothyroidism; Puberty, Precocious; Thyroxine | 1986 |
Dissociation between adrenarche and gonadarche in two longstanding hypothyroid youngsters.
Topics: Adolescent; Adrenal Glands; Female; Humans; Hypothyroidism; Male; Ovary; Puberty, Precocious; Testis | 1986 |
[Juvenile hypothyreosis with premature menarche in trisomy 21 (author's transl)].
Topics: Adolescent; Age Factors; Chromosomes, Human, 21-22 and Y; Down Syndrome; Female; Humans; Hypothyroid | 1974 |
Serum gonadotropins in hypothyroid girls with and without sexual precocity.
Topics: Antibodies; Binding, Competitive; Blood Urea Nitrogen; Female; Follicle Stimulating Hormone; Growth | 1974 |
Juvenile hypothyroidism with testicular enlargement.
Topics: Adolescent; Adult; Biopsy; Bone Development; Child; Child, Preschool; Gonadotropins; Humans; Hypothy | 1970 |