thyroxine has been researched along with Encephalopathy, Toxic in 8 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neurotoxicity of iodine deficiency-induced hypothyroidism during developmental period results in serious impairments of brain function, such as learning and memory." | 7.79 | Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by phosphatidylinositol 3-kinase signaling pathway. ( Chen, J; Dong, J; Min, H; Song, B; Teng, W; Wang, Y; Wei, W, 2013) |
| " Developmental hyperthyroidism was simulated by static waterborne exposure of zebrafish to varying concentrations (3-300 nM) of thyroxine (T4) or triiodothyronine (T3) beginning at 6 h post-fertilization (hpf) and continuing through 5 days post-fertilization (dpf)." | 3.91 | Changes in thyroid hormone activity disrupt photomotor behavior of larval zebrafish. ( Chen, X; Harvey, DJ; Lein, PJ; Miller, GW; Puschner, B; Walter, KM, 2019) |
| "Neurotoxicity of iodine deficiency-induced hypothyroidism during developmental period results in serious impairments of brain function, such as learning and memory." | 3.79 | Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by phosphatidylinositol 3-kinase signaling pathway. ( Chen, J; Dong, J; Min, H; Song, B; Teng, W; Wang, Y; Wei, W, 2013) |
| " Since an optimal study design for testing potential developmental neurotoxicants in rats, should include exposure during both the pre- and postnatal periods of brain development, we suggest that in the case of triclosan, direct dosing of pups may be the best way to obtain that goal." | 1.39 | Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring. ( Axelstad, M; Boberg, J; Christiansen, S; Hass, U; Vinggaard, AM, 2013) |
| "A key feature of Parkinson's disease is the dopaminergic neuronal cell loss in the substantia nigra pars compacta." | 1.39 | Role of L-thyroxin in counteracting rotenone induced neurotoxicity in rats. ( El-Gamal, A; El-Gamal, M; Ellaithy, A; Helmy, B; Mohamed, M; Reda, A; Salama, M; Sheashaa, H; Sobh, M; Tantawy, D, 2013) |
| " Recent studies, indicating that even small changes in the mother's thyroid hormone status early in pregnancy may cause adverse effects on her child, have lead to increased concern for thyroid hormone disrupting chemicals in the environment." | 1.35 | Developmental neurotoxicity of propylthiouracil (PTU) in rats: relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes. ( Axelstad, M; Boberg, J; Bonnichsen, M; Hansen, PR; Hass, U; Hougaard, KS; Lund, SP; Nellemann, C, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Walter, KM | 1 |
| Miller, GW | 1 |
| Chen, X | 1 |
| Harvey, DJ | 1 |
| Puschner, B | 1 |
| Lein, PJ | 1 |
| Slotkin, TA | 1 |
| Cooper, EM | 1 |
| Stapleton, HM | 1 |
| Seidler, FJ | 1 |
| Wang, Y | 2 |
| Wei, W | 1 |
| Dong, J | 1 |
| Song, B | 1 |
| Min, H | 1 |
| Teng, W | 1 |
| Chen, J | 1 |
| Axelstad, M | 2 |
| Boberg, J | 2 |
| Vinggaard, AM | 1 |
| Christiansen, S | 1 |
| Hass, U | 2 |
| Faber, W | 1 |
| Kirkpatrick, D | 1 |
| Coder, P | 1 |
| Li, A | 1 |
| Borghoff, S | 1 |
| Banton, M | 1 |
| Hansen, PR | 1 |
| Bonnichsen, M | 1 |
| Nellemann, C | 1 |
| Lund, SP | 1 |
| Hougaard, KS | 1 |
| Salama, M | 1 |
| Helmy, B | 1 |
| El-Gamal, M | 1 |
| Reda, A | 1 |
| Ellaithy, A | 1 |
| Tantawy, D | 1 |
| Mohamed, M | 1 |
| El-Gamal, A | 1 |
| Sheashaa, H | 1 |
| Sobh, M | 1 |
| Sprague, JE | 1 |
| Banks, ML | 1 |
| Cook, VJ | 1 |
| Mills, EM | 1 |
8 other studies available for thyroxine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Changes in thyroid hormone activity disrupt photomotor behavior of larval zebrafish.
Topics: Animals; Antithyroid Agents; Embryo, Nonmammalian; Female; Hyperthyroidism; Hypothyroidism; Larva; M | 2019 |
Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?
Topics: Age Factors; Animals; Brain; Chlorpyrifos; Female; Gestational Age; Insecticides; Male; Maternal Exp | 2013 |
Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by phosphatidylinositol 3-kinase signaling pathway.
Topics: Animals; Antithyroid Agents; Blotting, Western; CA1 Region, Hippocampal; Diet; Electric Stimulation; | 2013 |
Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring.
Topics: Animals; Animals, Newborn; Anti-Infective Agents, Local; Brain; Dose-Response Relationship, Drug; En | 2013 |
Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC).
Topics: Acetates; Adrenal Glands; Alpha-Globulins; Animals; Female; Kidney; Liver; Male; Maternal-Fetal Exch | 2014 |
Developmental neurotoxicity of propylthiouracil (PTU) in rats: relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes.
Topics: Age Factors; Animals; Animals, Newborn; Antithyroid Agents; Auditory Threshold; Behavior, Animal; Bo | 2008 |
Role of L-thyroxin in counteracting rotenone induced neurotoxicity in rats.
Topics: Animals; Catalepsy; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Microglia; Neurop | 2013 |
Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy).
Topics: 3,4-Methylenedioxyamphetamine; Adrenergic alpha-Antagonists; Animals; Drug Interactions; Fever; Hypo | 2003 |