thyroxine has been researched along with Dementia in 30 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levothyroxine treatment is common among older adults as is atrial fibrillation (AF), yet less is known about its potential effects on the development of dementia." | 7.96 | Levothyroxine treatment and incident dementia in adults with atrial fibrillation. ( Carlsson, AC; Li, X; Sundquist, J; Sundquist, K; Wändell, P, 2020) |
| "The possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated." | 7.91 | Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism. ( Carlsson, AC; Sundquist, J; Sundquist, K; Wändell, P, 2019) |
| "Levothyroxine treatment is common among older adults as is atrial fibrillation (AF), yet less is known about its potential effects on the development of dementia." | 3.96 | Levothyroxine treatment and incident dementia in adults with atrial fibrillation. ( Carlsson, AC; Li, X; Sundquist, J; Sundquist, K; Wändell, P, 2020) |
| "The possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated." | 3.91 | Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism. ( Carlsson, AC; Sundquist, J; Sundquist, K; Wändell, P, 2019) |
| " We evaluated the association of thyroid-stimulating hormone (TSH) and free thyroxine with incident dementia using Cox models adjusted for age, sex, cardiovascular risk factors, and education." | 3.83 | Thyroid function and the risk of dementia: The Rotterdam Study. ( Bos, D; Chaker, L; Dehghan, A; Franco, OH; Hofman, A; Ikram, MA; Korevaar, TI; Koudstaal, PJ; Peeters, RP; van der Lugt, A; Vernooij, MW; Wolters, FJ, 2016) |
| "To analyze associations between thyroid-stimulating hormone (TSH) and free thyroxine (FT4 concentrations and life satisfaction, symptoms, self-rated health, and common neuropsychiatric diseases (depression or dementia) in a community-dwelling elderly population to provide evidence whether to decrease the upper reference limit for TSH or the optimal TSH target in levothyroxine treatment in older adults." | 3.74 | Associations of thyroid-stimulating hormone and free thyroxine concentrations with health and life satisfaction in elderly adults. ( Eskelinen, SI; Irjala, KM; Isoaho, RE; Kivelä, SL; Löppönen, MK; Vahlberg, TJ, 2007) |
| " This diabetes insipidus is reversible, non-progressive, unrelated to plasma level, and distinct in attack from lithium-induced hypothyroidism, which may occur at low dosage but is also usually of late onset and reversible or treatable with thyroxine while lithium is continued." | 3.65 | Blood levels and management of lithium treatment. ( Crammer, JL; Crane, G; Rosser, RM, 1974) |
| "Subclinical hypothyroidism is more common than HO and is most prevalent in the elderly, particularly in women." | 2.42 | Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderly. ( Davis, JD; Flashman, LA; Stern, RA, 2003) |
| "When hypothyroidism is detected in a patient with suspected dementia, thyroxin should be tried first of all." | 2.41 | [Dementia and hypothyroidism]. ( Fylkesnes, SI; Nygaard, HA, 2000) |
| "Hypothyroidism is among the most frequent causes of reversible dementias." | 1.29 | [Reversibility of dementia in hypothyroidism]. ( Haupt, M; Kurz, A, 1993) |
| "Hypothyroidism is a reversible cause for dementia." | 1.28 | Hypothyroidism producing reversible dementia. A challenge for medical rehabilitation. ( Granger, CV; Smith, CL, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (30.00) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 6 (20.00) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ge, YJ | 1 |
| Xu, W | 1 |
| Tan, CC | 1 |
| Tan, L | 1 |
| Quinlan, P | 1 |
| Horvath, A | 1 |
| Wallin, A | 1 |
| Svensson, J | 1 |
| Wändell, P | 2 |
| Carlsson, AC | 2 |
| Sundquist, J | 2 |
| Sundquist, K | 2 |
| Li, X | 1 |
| Wu, Y | 1 |
| Pei, Y | 1 |
| Wang, F | 1 |
| Xu, D | 1 |
| Cui, W | 1 |
| Chaker, L | 1 |
| Wolters, FJ | 1 |
| Bos, D | 1 |
| Korevaar, TI | 1 |
| Hofman, A | 3 |
| van der Lugt, A | 1 |
| Koudstaal, PJ | 1 |
| Franco, OH | 1 |
| Dehghan, A | 1 |
| Vernooij, MW | 1 |
| Peeters, RP | 1 |
| Ikram, MA | 1 |
| Yeap, BB | 1 |
| Alfonso, H | 1 |
| Chubb, SA | 1 |
| Puri, G | 1 |
| Hankey, GJ | 1 |
| Flicker, L | 1 |
| Almeida, OP | 1 |
| Persson, N | 1 |
| Viitanen, M | 1 |
| Almkvist, O | 1 |
| Wahlin, Å | 1 |
| Davis, JD | 1 |
| Stern, RA | 1 |
| Flashman, LA | 1 |
| Hashimoto, T | 1 |
| Miki, T | 1 |
| de Jong, FJ | 1 |
| den Heijer, T | 1 |
| Visser, TJ | 1 |
| de Rijke, YB | 1 |
| Drexhage, HA | 2 |
| Breteler, MM | 2 |
| Peiris, AN | 1 |
| Oh, E | 1 |
| Diaz, S | 1 |
| Eskelinen, SI | 1 |
| Vahlberg, TJ | 1 |
| Isoaho, RE | 1 |
| Löppönen, MK | 1 |
| Kivelä, SL | 1 |
| Irjala, KM | 1 |
| Thase, ME | 1 |
| Inada, M | 1 |
| Stähelin, HB | 1 |
| Staub, JJ | 1 |
| Hew-Winzeler, AM | 1 |
| Seiler, WO | 1 |
| Girard, J | 1 |
| Haupt, M | 2 |
| Kurz, A | 2 |
| Prinz, PN | 1 |
| Scanlan, JM | 1 |
| Vitaliano, PP | 1 |
| Moe, KE | 1 |
| Borson, S | 1 |
| Toivola, B | 1 |
| Merriam, GR | 1 |
| Larsen, LH | 1 |
| Reed, HL | 1 |
| Fylkesnes, SI | 1 |
| Nygaard, HA | 1 |
| Kalmijn, S | 1 |
| Mehta, KM | 1 |
| Pols, HA | 1 |
| Vardi, Y | 1 |
| Czerniak, P | 1 |
| Rabey, Y | 1 |
| Flechter, S | 1 |
| Boruchowsky, S | 1 |
| Streifler, M | 1 |
| Hontela, S | 1 |
| Smith, CL | 1 |
| Granger, CV | 1 |
| Nakanishi, T | 1 |
| Chopra, IJ | 1 |
| Solomon, DH | 1 |
| Huang, TS | 1 |
| Rosenthal, MJ | 1 |
| Sanchez, CJ | 1 |
| Cropper, CF | 1 |
| Crammer, JL | 1 |
| Rosser, RM | 1 |
| Crane, G | 1 |
| Hunter, GM | 1 |
| Irvine, RE | 1 |
| Bagnall, MK | 1 |
5 reviews available for thyroxine and Dementia
| Article | Year |
|---|---|
Blood-based biomarkers in hypothalamic-pituitary axes for the risk of dementia or cognitive decline: a systematic review and meta-analysis.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognition; Cognitive Dysfunction; Dementia; Female; Humans; Hyp | 2020 |
Higher FT4 or TSH below the normal range are associated with increased risk of dementia: a meta-analysis of 11 studies.
Topics: Databases, Factual; Dementia; Humans; Reference Values; Risk Factors; Thyrotropin; Thyroxine | 2016 |
Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderly.
Topics: Aged; Clinical Trials as Topic; Cognition Disorders; Dementia; Depressive Disorder; Humans; Hypothal | 2003 |
[Hypothyroidism].
Topics: Dementia; Diagnosis, Differential; Hormone Replacement Therapy; Humans; Hypothyroidism; Thyroid Func | 2004 |
[Dementia and hypothyroidism].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Diagnosis, Differential | 2000 |
1 trial available for thyroxine and Dementia
| Article | Year |
|---|---|
Higher free thyroxine levels predict increased incidence of dementia in older men: the Health in Men Study.
Topics: Age of Onset; Aged; Aged, 80 and over; Aging; Dementia; Health; Humans; Incidence; Longitudinal Stud | 2012 |
24 other studies available for thyroxine and Dementia
| Article | Year |
|---|---|
Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cognitive Dysfunction; Dementia; Dementia, Vascular; Female; Follow-Up Stud | 2019 |
Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism.
Topics: Aged; Aged, 80 and over; Atrial Fibrillation; Dementia; Female; Humans; Hypothyroidism; Male; Middle | 2019 |
Levothyroxine treatment and incident dementia in adults with atrial fibrillation.
Topics: Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Case-Control Studies; Comorbidity; Cross-Sectio | 2020 |
Thyroid function and the risk of dementia: The Rotterdam Study.
Topics: Aged; Brain; Cardiovascular Diseases; Cross-Sectional Studies; Dementia; Follow-Up Studies; Humans; | 2016 |
A principal component model of medical health: implications for cognitive deficits and decline among adults in a population-based sample.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Blood Glucose; Cholesterol; Cognition; Cognition | 2013 |
Thyroid hormones, dementia, and atrophy of the medial temporal lobe.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Atrophy; Cohort Studies; Dementia; Follow-Up S | 2006 |
Psychiatric manifestations of thyroid disease.
Topics: Anxiety Disorders; Confusion; Delusions; Dementia; Depression; Hallucinations; Humans; Hyperthyroidi | 2007 |
Associations of thyroid-stimulating hormone and free thyroxine concentrations with health and life satisfaction in elderly adults.
Topics: Age Distribution; Aged; Aged, 80 and over; Chemistry, Clinical; Cross-Sectional Studies; Dementia; D | 2007 |
Reversible dementia in Down's syndrome.
Topics: Adult; Alzheimer Disease; Dementia; Diagnosis, Differential; Down Syndrome; Female; Humans; Hypothyr | 1982 |
[Aging and thyroid function].
Topics: Adult; Aged; Aging; Cardiac Output; Dementia; Diiodothyronines; Female; Humans; Male; Middle Aged; T | 1984 |
[TRH-TSH regulation in the aged and in patients with senile dementia].
Topics: Aged; Aging; Dementia; Female; Goiter; Humans; Male; Thyrotropin; Thyrotropin-Releasing Hormone; Thy | 1982 |
[Reversibility of dementia in hypothyroidism].
Topics: Dementia; Female; Humans; Hypothyroidism; Long-Term Care; Middle Aged; Neuropsychological Tests; Thy | 1993 |
Reversibility of dementia in hypothyroidism.
Topics: Cognition; Dementia; Female; Humans; Hypothyroidism; Middle Aged; Neuropsychological Tests; Prospect | 1993 |
Thyroid hormones: positive relationships with cognition in healthy, euthyroid older men.
Topics: Aged; Aging; Cognition; Cognition Disorders; Dementia; Educational Status; Humans; Hypothyroidism; I | 1999 |
Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study.
Topics: Aged; Alzheimer Disease; Autoantibodies; Dementia; Female; Follow-Up Studies; Humans; Hyperthyroidis | 2000 |
Blood-C.S.F. barriers dysfunction in the chronic organic brain syndrome; a R.I.A. study.
Topics: Adult; Aged; Blood-Brain Barrier; Cerebrospinal Fluid Proteins; Dementia; Electroencephalography; Fe | 1978 |
Triiodothyronine turnover in hospitalized psychogeriatric patients.
Topics: Aged; Dementia; Female; Hospitalization; Humans; Kinetics; Male; Thyrotropin; Thyroxine; Triiodothyr | 1975 |
Hypothyroidism producing reversible dementia. A challenge for medical rehabilitation.
Topics: Aged; Aged, 80 and over; Dementia; Diagnosis, Differential; Female; Humans; Hypothyroidism; Male; Me | 1992 |
Consideration on serum triiodothyronine (T3), thyroxine (T4) concentration and T3/T4 ratio in the patients of senile dementia--is it possible to prevent cerebro-vascular dementia?
Topics: Aged; Aged, 80 and over; Dementia; Dementia, Multi-Infarct; Female; Humans; Male; Middle Aged; Thyro | 1990 |
Serum thyrotropin in hospitalized psychiatric patients: evidence for hyperthyrotropinemia as measured by an ultrasensitive thyrotropin assay.
Topics: Adult; Aged; Aged, 80 and over; Bipolar Disorder; Dementia; Depression; Female; Humans; Male; Mental | 1990 |
Thyroid disease in the elderly--missed diagnosis or overdiagnosis?
Topics: Aged; Dementia; Diagnosis, Differential; Humans; Hypothyroidism; Male; Thyroid Diseases; Thyroxine; | 1985 |
Hypothyroidism in psychogeriatric patients--ankle jerk reaction time as a screening technique.
Topics: Achilles Tendon; Aged; Dementia; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Mass Screeni | 1973 |
Blood levels and management of lithium treatment.
Topics: Administration, Oral; Adult; Aged; Carbimazole; Delayed-Action Preparations; Dementia; Depression; D | 1974 |
Medical and social problems of two elderly women.
Topics: Aged; Cervical Vertebrae; Dementia; Depression; Female; Gastrectomy; Home Care Services; Humans; Hyp | 1972 |