thyroxine has been researched along with Delayed Effects, Prenatal Exposure in 212 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is a follow-up study of the Tehran Thyroid and Pregnancy Study, a randomized trial in which subclinical hypothyroid pregnant women were assigned to an intervention group (treated with levothyroxine) or a control group (received no treatment)." | 9.30 | Evaluation of the impact of levothyroxine treatment on the psychomotor developmental status of three-year-old children born to mothers with mild thyroid impairment; Tehran Thyroid and pregnancy study: study protocol for a randomized clinical trial. ( Azizi, F; Bidhendi Yarandi, R; Nazarpour, S; Ramezani Tehrani, F; Sajedi, F, 2019) |
| "Among 422,156 mother-child pairs, 2125 children were born from mothers exposed to levothyroxine during pregnancy." | 8.12 | Association of maternal levothyroxine use during pregnancy with offspring birth and neurodevelopmental outcomes: a population-based cohort study. ( Cheung, CL; Cheung, ECL; Ge, GM; Ip, P; Kung, AWC; Leung, WC; Li, GHY; Man, KKC; Wong, ICK, 2022) |
| "025% [w/v]) was administered to dams from two weeks prior to conception until delivery, which succeeded in inducing mild maternal hypothyroxinemia during pregnancy." | 7.88 | Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring. ( Fujita, K; Hamaguchi, M; Hanzawa, N; Hashimoto, K; Kase, S; Kawahori, K; Nakajima, Y; Ogawa, Y; Okazawa, H; Shibusawa, N; Tagawa, K; Tsujimoto, K; Yamada, M; Yuan, X, 2018) |
| "In a large, national birth cohort, prospectively documented hypothyroxinemia during early gestation to mid-gestation was associated with increased odds of schizophrenia in offspring." | 7.83 | Hypothyroxinemia During Gestation and Offspring Schizophrenia in a National Birth Cohort. ( Brown, AS; Gyllenberg, D; Hinkka-Yli-Salomäki, S; McKeague, IW; Sourander, A; Surcel, HM, 2016) |
| "To investigate whether fetal exposure to antithyroid drugs (ATD) and levothyroxine affects gestational age (GA), birth weight, birth length, head circumference and prevalence of congenital anomalies." | 7.83 | Pregnancy outcomes after fetal exposure to antithyroid medications or levothyroxine. ( Garne, E; Hansen, AV; Schurmann, L, 2016) |
| "The timing of thyroxine (T4) replacement treatment in congenital hypothyroidism (CH) has been suggested to be important for optimizing cognitive recovery in humans; however this has not been fully established using modern animal models of CH." | 7.81 | Effects of thyroxine treatment on histology and behavior using the methimazole model of congenital hypothyroidism in the rat. ( Kim, EM; O'Hare, E; Page, D; Reid, R, 2015) |
| "The children of mothers with hypothyroxinemia in early pregnancy scored 4." | 7.80 | Downstream effects of maternal hypothyroxinemia in early pregnancy: nonverbal IQ and brain morphology in school-age children. ( El Marroun, H; Ghassabian, A; Hofman, A; Jaddoe, VW; Peeters, RP; Tiemeier, H; Verhulst, FC; White, T, 2014) |
| "Low free thyroxine levels (<5th percentile) and self-reported prepregnancy thyroid disorder without medical treatment were associated with a decrease of mental scores (Beta = -3." | 7.79 | Thyroxine levels during pregnancy in healthy women and early child neurodevelopment. ( Alvarez-Pedrerol, M; Espada, M; Forns, J; Garcia-Esteban, R; Julvez, J; Lertxundi, N; Murcia, M; Rebagliato, M; Riaño Galán, I; Sunyer, J; Tardón, A, 2013) |
| "Transient gestational hypothyroxinemia in rodents induces cortical neuronal migration brain lesions resembling those of autism." | 7.79 | Association of gestational maternal hypothyroxinemia and increased autism risk. ( Bongers-Schokking, JJ; de Rijke, YB; Ghassabian, A; Hofman, A; Jaddoe, VW; Román, GC; Tiemeier, H; Verhulst, FC, 2013) |
| "Expression of autism candidates, Gabrb3, Ube3a, Mecp2, and Slc25a12, was significantly increased in the hippocampus of male offspring of EtOH dams." | 5.39 | Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. ( Redei, EE; Shukla, PK; Tunc-Ozcan, E; Ullmann, TM, 2013) |
| " Thyroxine supplementation during pregnancy requires monitoring to avoid overtreatment." | 5.34 | Controlled Antenatal Thyroid Screening II: Effect of Treating Maternal Suboptimal Thyroid Function on Child Behavior. ( Channon, S; Dayan, C; Draman, MS; Gregory, JW; Hales, C; Langley, K; Lazarus, JH; Ludgate, M; McEwan, K; Muller, I; Okosieme, O; Rees, DA; Taylor, PN; Thapar, A, 2020) |
| "This is a follow-up study of the Tehran Thyroid and Pregnancy Study, a randomized trial in which subclinical hypothyroid pregnant women were assigned to an intervention group (treated with levothyroxine) or a control group (received no treatment)." | 5.30 | Evaluation of the impact of levothyroxine treatment on the psychomotor developmental status of three-year-old children born to mothers with mild thyroid impairment; Tehran Thyroid and pregnancy study: study protocol for a randomized clinical trial. ( Azizi, F; Bidhendi Yarandi, R; Nazarpour, S; Ramezani Tehrani, F; Sajedi, F, 2019) |
| " Currently, there is no evidence that levothyroxine treatment, when initiated 8- to 20-week gestation (mostly between 12 and 17 weeks), for mild maternal thyroid hormone insufficiency during pregnancy reduces intellectual disability in offspring." | 4.98 | Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis. ( Baragwanath, G; Matthews, J; Russell, G; Thompson, W; Thompson-Coon, J; Vaidya, B, 2018) |
| "Isolated hypothyroxinemia (IH) is defined as a thyroxine level in the lower 5th (severe IH) or 10th percentile (mild IH) of the pregnancy-related reference range and a normal TSH." | 4.91 | Update on a new controversy in endocrinology: isolated maternal hypothyroxinemia. ( Daumerie, C; Furnica, RM; Gruson, D; Lazarus, JH, 2015) |
| "Exposure to maternal hypothyroxinemia during pregnancy, which is characterized by low free T4 but normal thyroid-stimulating hormone (TSH) levels, can negatively affect the foetus." | 4.89 | Maternal hypothyroxinemia and effects on cognitive functioning in childhood: how and why? ( Ghassabian, A; Henrichs, J; Peeters, RP; Tiemeier, H, 2013) |
| " Advances in the knowledge of thyroid physiology and its changes in normal pregnancy have now led to the realization of the potential importance of minor changes in maternal thyroxine (T4) concentrations in relation to brain maturation and development." | 4.80 | Thyroid hormone and intellectual development: a clinician's view. ( Lazarus, JH, 1999) |
| " Propensity score fine-stratification weighted hazard ratios (wHR) with 95% confidence intervals (CIs) were presented to assess the association between maternal levothyroxine use during pregnancy and seizures in children." | 4.31 | Levothyroxine Treatment Among Pregnant Women and Risk of Seizure in Children: A Population-Based Cohort Study. ( Cheung, CL; Cheung, ECL; Ge, GM; Ip, P; Kung, AWC; Leung, WC; Man, KKC; Wong, ICK, 2023) |
| "Among 422,156 mother-child pairs, 2125 children were born from mothers exposed to levothyroxine during pregnancy." | 4.12 | Association of maternal levothyroxine use during pregnancy with offspring birth and neurodevelopmental outcomes: a population-based cohort study. ( Cheung, CL; Cheung, ECL; Ge, GM; Ip, P; Kung, AWC; Leung, WC; Li, GHY; Man, KKC; Wong, ICK, 2022) |
| "Exposure to maternal hypothyroxinemia was associated with a five-fold increased risk of offspring bipolar disorder with psychotic features, but not without psychotic features." | 3.96 | The association of serologically documented maternal thyroid conditions during pregnancy with bipolar disorder in offspring. ( Brown, AS; Cheslack-Postava, K; Spann, MN, 2020) |
| "The Controlled Antenatal Thyroid Screening Study I (CATS-I) was a randomized controlled trial investigating the effects of levothyroxine therapy for suboptimal gestational thyroid function (SGTF), comparing outcomes in children of treated (SGTF-T) with untreated (SGTF-U) women during pregnancy." | 3.96 | CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers. ( Candler, T; Daniel, RM; Dayan, CM; Draman, MS; Evans, WD; Gregory, JW; Hales, C; Lazarus, JH; Ludgate, ME; Muller, I; Okosieme, O; Pettit, RJ; Rees, DA; Scholz, A; Shillabeer, D; Tang, HKC; Taylor, PN, 2020) |
| "Levothyroxine treatment for hypothyroidism in early pregnancy has inconsistent outcomes." | 3.96 | Impact of Preconception Treatment Initiation for Hypothyroidism on Neurocognitive Function in Children. ( Li, X; Wang, C; Xu, H; Zhou, Q, 2020) |
| "Triclosan was not associated with thyroid hormones during pregnancy." | 3.88 | Associations of early life urinary triclosan concentrations with maternal, neonatal, and child thyroid hormone levels. ( Braun, JM; Chen, A; Hauser, R; Hoofnagle, A; Jackson-Browne, M; Karagas, MR; Lanphear, BP; Papandonatos, GD; Romano, ME; Thomas Zoeller, R; Yolton, K, 2018) |
| "Maternal thyroxine during pregnancy did not improve child cognition at age 9." | 3.88 | Controlled Antenatal Thyroid Screening II: Effect of Treating Maternal Suboptimal Thyroid Function on Child Cognition. ( Bakhsh, A; Channon, S; Dayan, C; Draman, MS; Gregory, JW; Gyedu, M; Hales, C; Lazarus, JH; Ludgate, M; McEwan, K; Muller, I; Okosieme, O; Paradice, R; Rees, DA; Taylor, PN; Zhang, L, 2018) |
| "025% [w/v]) was administered to dams from two weeks prior to conception until delivery, which succeeded in inducing mild maternal hypothyroxinemia during pregnancy." | 3.88 | Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring. ( Fujita, K; Hamaguchi, M; Hanzawa, N; Hashimoto, K; Kase, S; Kawahori, K; Nakajima, Y; Ogawa, Y; Okazawa, H; Shibusawa, N; Tagawa, K; Tsujimoto, K; Yamada, M; Yuan, X, 2018) |
| " All women had a blood sample drawn in early pregnancy (median week 9), and the stored sample was used for measurement of free thyroxine and thyrotropin." | 3.88 | Maternal Thyroid Function in Early Pregnancy and Child Neurodevelopmental Disorders: A Danish Nationwide Case-Cohort Study. ( Andersen, S; Andersen, SL; Olsen, J; Vestergaard, P, 2018) |
| "Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring." | 3.88 | Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis. ( Albornoz, E; Binzberger, R; Bueno, SM; Bugueño, K; Cabello-Verrugio, C; Elorza, AA; Haensgen, H; Jara Fernández, EL; Kalergis, AM; Opazo, MC; Riedel, CA; Rivero-Castillo, T; Simon, F; Venegas Salas, LF, 2018) |
| " It is unknown, however, whether the relationships between maternal thyrotropin (TSH) and free thyroxine (fT4) levels in early pregnancy and fetal growth outcomes are modified by fetal sex." | 3.85 | Early Maternal Thyroid Function During Gestation Is Associated With Fetal Growth, Particularly in Male Newborns. ( Hrudey, EJ; Twickler, MB; Vrijkotte, TG, 2017) |
| "We investigated the effects of hydroalcoholic extract of Nigella sativa (NS) on renal tissue oxidative damage associated with propylthiouracil (PTU)-induced hypothyroidism during neonatal and juvenile growth in rats." | 3.85 | Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats. ( Beheshti, F; Haghshenas, M; Hosseini, M; Mohebbati, R; Nazariborun, A, 2017) |
| " Here we used mouse models of maternal hypo- and hyperthyroidism to investigate the long-term effects of altering thyroxine (T4) levels during pregnancy (corresponding to embryonic days 6." | 3.85 | Opposing Effects of Maternal Hypo- and Hyperthyroidism on the Stability of Thalamocortical Synapses in the Visual Cortex of Adult Offspring. ( Coleman, JE; Freeman, D; Patel, J; Poulsen, R; Rivkees, SA; Strobl, MJ; Wendler, CC, 2017) |
| "In a large, national birth cohort, prospectively documented hypothyroxinemia during early gestation to mid-gestation was associated with increased odds of schizophrenia in offspring." | 3.83 | Hypothyroxinemia During Gestation and Offspring Schizophrenia in a National Birth Cohort. ( Brown, AS; Gyllenberg, D; Hinkka-Yli-Salomäki, S; McKeague, IW; Sourander, A; Surcel, HM, 2016) |
| "To investigate whether fetal exposure to antithyroid drugs (ATD) and levothyroxine affects gestational age (GA), birth weight, birth length, head circumference and prevalence of congenital anomalies." | 3.83 | Pregnancy outcomes after fetal exposure to antithyroid medications or levothyroxine. ( Garne, E; Hansen, AV; Schurmann, L, 2016) |
| "028), but not with maternal free thyroxine concentrations at any stage of pregnancy." | 3.83 | Effects of Maternal Iodine Nutrition and Thyroid Status on Cognitive Development in Offspring: A Pilot Study. ( Alibrandi, A; Candia Longo, A; Giorgianni, G; Moleti, M; Sturniolo, G; Tortorella, G; Trimarchi, F; Vermiglio, F, 2016) |
| "Maternal hypothyroidism and/or hypothyroxinemia have been associated with child's poor neuropsychological development, but the results have been inconsistent." | 3.81 | Maternal and Child's Thyroid Function and Child's Intellect and Scholastic Performance. ( Bloigu, A; Hartikainen, AL; Järvelin, MR; Männistö, T; Moilanen, I; Päkkilä, F; Ruokonen, A; Surcel, HM; Suvanto, E; Vääräsmäki, M, 2015) |
| "Excessive iodine intake during pregnancy was associated with an increased rate of hyperthyrotropinaemia in neonates and their mothers, especially in male neonates." | 3.81 | Neonatal thyroid function born to mothers living with long-term excessive iodine intake from drinking water. ( Chen, W; Chu, Z; Dong, F; Sang, Z; Shen, J; Tan, L; Wei, W; Yao, Z; Zhang, G; Zhang, S; Zhang, W; Zhao, N, 2015) |
| "The timing of thyroxine (T4) replacement treatment in congenital hypothyroidism (CH) has been suggested to be important for optimizing cognitive recovery in humans; however this has not been fully established using modern animal models of CH." | 3.81 | Effects of thyroxine treatment on histology and behavior using the methimazole model of congenital hypothyroidism in the rat. ( Kim, EM; O'Hare, E; Page, D; Reid, R, 2015) |
| "Children exposed to maternal hypothyroxinemia in early pregnancy had more ADHD symptoms, independent of confounders." | 3.81 | Maternal Mild Thyroid Hormone Insufficiency in Early Pregnancy and Attention-Deficit/Hyperactivity Disorder Symptoms in Children. ( Ghassabian, A; Hofman, A; Jaddoe, VW; Modesto, T; Peeters, RP; Tiemeier, H; Verhulst, FC, 2015) |
| "The children of mothers with hypothyroxinemia in early pregnancy scored 4." | 3.80 | Downstream effects of maternal hypothyroxinemia in early pregnancy: nonverbal IQ and brain morphology in school-age children. ( El Marroun, H; Ghassabian, A; Hofman, A; Jaddoe, VW; Peeters, RP; Tiemeier, H; Verhulst, FC; White, T, 2014) |
| "Excessive iodine exposure during the fetal and neonatal periods can lead to neonatal hypothyroidism." | 3.80 | Effect of iodine loading on the thyroid hormone level of newborns living in Kayseri province. ( Bastug, O; Daar, G; Gunes, T; Halis, H; Korkmaz, L; Korkut, S; Kurtoglu, S; Memur, S; Ozturk, MA, 2014) |
| " We have previously reported the presence of SBH in a rodent model of low level hypothyroidism induced by maternal exposure to the goitrogen, propylthiouracil (PTU)." | 3.80 | Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics. ( Gilbert, ME; Goodman, JH; McCloskey, DP; Ramos, RL, 2014) |
| "Transient gestational hypothyroxinemia in rodents induces cortical neuronal migration brain lesions resembling those of autism." | 3.79 | Association of gestational maternal hypothyroxinemia and increased autism risk. ( Bongers-Schokking, JJ; de Rijke, YB; Ghassabian, A; Hofman, A; Jaddoe, VW; Román, GC; Tiemeier, H; Verhulst, FC, 2013) |
| " Children of mothers with thyroid dysfunction (hypothyroidism, hyperthyroidism, or hypothyroxinemia) or TPO-Ab positivity were compared to those of euthyroid or TPO-Ab-negative mothers." | 3.79 | Maternal thyroid dysfunction during pregnancy and thyroid function of her child in adolescence. ( Bloigu, A; Hartikainen, AL; Järvelin, MR; Männistö, T; Päkkilä, F; Pouta, A; Ruokonen, A; Surcel, HM; Suvanto, E; Vääräsmäki, M, 2013) |
| " Effects included increased serum thyroxine levels and reduced hepatic carboxylesterease activity in dams, and advanced female puberty, weight gain, male cardiac hypertrophy, and altered exploratory behaviors in offspring." | 3.79 | Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. ( Belcher, SM; Braun, J; Gear, RB; Mabrey, N; McCaffrey, KA; Patisaul, HB; Roberts, SC; Stapleton, HM, 2013) |
| " Severe perinatal hypothyroidism was obtained by administration of 30 mg/day propylthiouracil to dams." | 3.79 | Protein kinase Cα is involved in impaired perinatal hypothyroid rat brain development. ( Dong, Y; Lin, N; Luo, M; Su, Q; Zhang, HM, 2013) |
| "Low free thyroxine levels (<5th percentile) and self-reported prepregnancy thyroid disorder without medical treatment were associated with a decrease of mental scores (Beta = -3." | 3.79 | Thyroxine levels during pregnancy in healthy women and early child neurodevelopment. ( Alvarez-Pedrerol, M; Espada, M; Forns, J; Garcia-Esteban, R; Julvez, J; Lertxundi, N; Murcia, M; Rebagliato, M; Riaño Galán, I; Sunyer, J; Tardón, A, 2013) |
| "Lower neurocognitive development scores at age 2 yr have been reported in association with euthyroid hypothyroxinemia during early pregnancy." | 3.78 | Mid-gestational maternal free thyroxine concentration and offspring neurocognitive development at age two years. ( Allan, WC; Craig, WY; Haddow, JE; Kloza, EM; Neveux, LM; Palomaki, GE; Pulkkinen, AJ; Spratt, DI; Waisbren, S, 2012) |
| "To investigate the effects of maternal selenium (Se) supplementation and nutritional intake during gestation on hormone changes, percentage body weight (BW) change, and organ mass in neonatal lambs, ewes were allocated to differing Se levels (adequate Se (ASe, 11." | 3.78 | Neonatal hormone changes and growth in lambs born to dams receiving differing nutritional intakes and selenium supplementation during gestation. ( Camacho, LE; Caton, JS; Hammer, CJ; Meyer, AM; Neville, TL; Redmer, DA; Reynolds, LP; Vonnahme, KA, 2012) |
| "After 12 weeks of treatment (before pregnancy), iodine concentrations in urine and thyroid tissue and circulating thyroxine of adult females correlated with iodine intake." | 3.78 | Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring. ( Fan, C; Li, J; Liu, Y; Mao, J; Shan, Z; Teng, W; Wang, H; Zhang, H; Zhang, L, 2012) |
| "Our results indicate a risk of postnatal hypothyroidism among lambs from pregnant and lactating ewes having a high iodine intake." | 3.78 | The impact of high iodine intake on thyroid function in ewes and lambs. ( Baňoch, T; Dušová, H; Konečný, R; Kroupová, V; Peksa, Z; Svoboda, M; Trávníček, J, 2012) |
| "An adequate intake of iodine during pregnancy is essential for the synthesis of maternal thyroid hormones needed to support normal fetal development." | 3.77 | The effect of maternal iodine status on infant outcomes in an iodine-deficient Indian population. ( Das, PK; Ferguson, EL; Gray, AR; Menon, KC; Pandav, CS; Saraf, A; Skeaff, SA; Thomson, CD; Zodpey, S, 2011) |
| "02% methimazole (MMI) (w/v) in drinking water, while the experimental hyperthyroidism group is performed by exogenous T4 [from 50 to 200microg/kg body weight intragastric administration beside adding 0." | 3.76 | Comparative study of the effects of experimentally induced hypothyroidism and hyperthyroidism in some brain regions in albino rats. ( Ahmed, RG; El-Bakry, AM; El-Gareib, AW, 2010) |
| "In this study, the authors' objective was to determine whether serum concentrations of polychlorinated biphenyls (PCBs), hexachlorobenzene, p,p'-dichlorodiphenyl trichloroethane (DDT), o,p'-DDT, and p,p'-dichlorodiphenyl dichloroethylene (DDE) are associated with thyroid function during pregnancy." | 3.74 | Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy. ( Barr, DB; Bradman, A; Chevrier, J; Eskenazi, B; Holland, N, 2008) |
| "Hypothyroidism in the rat induced by perinatal exposure to propylthiouracil (PTU) is a useful animal model to study molecular changes underlying neurobehavioral defects associated with this condition." | 3.73 | Effects of hypothyroidism induced by perinatal exposure to PTU on rat behavior and synaptic gene expression. ( Kobayashi, K; Kushida, M; Mino, T; Sasaki, M; Seki, T; Tsuji, R; Yabushita, S; Yoshioka, T, 2005) |
| " More than 50% of the babies with transient hypothyroidism had been exposed to iodine; maternal transfer of antibodies had occurred in a third of them." | 3.70 | Neonatal transient hypothyroidism: aetiological study. Italian Collaborative Study on Transient Hypothyroidism. ( Bona, G; Chiumello, G; Rapa, A; Vigone, MC; Weber, G, 1998) |
| "Following the diagnosis of fetal goitre at 22 and 24 weeks' gestation in two hyperthyroid pregnant women who underwent treatment with 400-500 mg of propylthiouracil in the first weeks of pregnancy, a total of seven fetal blood samplings were performed to evaluate thyroid function before and after the initiation of two different treatment regimens." | 3.69 | Prenatal treatment of fetal hypothyroidism: is there more than one option? ( Acaia, B; Beck-Peccoz, P; Cortelazzi, D; Nicolini, U; Venegoni, E, 1996) |
| " Hypothyroidism was induced by treating the rats with a reversible goitrogen 6-n-propyl-2-thiouracil dissolved in their drinking water, while the hyperthyroid group was given water containing thyroxine." | 3.69 | Modulation by thyroid hormones of the development of external plexiform layer in the rat olfactory bulb. ( Halász, N; Hoyk, Z; Szilágyi, T, 1996) |
| " Urinary bis(1,3-dichloro-2-propyl)-phosphate concentrations were generally associated with decreased triiodothyronine and thyroxine levels and increased thyroid-stimulating hormone levels in maternal and newborn thyroid hormones in quartile dose-response analyses and multiple informant models." | 1.62 | Maternal Urinary Organophosphate Esters and Alterations in Maternal and Neonatal Thyroid Hormones. ( Braun, JM; Calafat, AM; Cecil, KM; Chen, A; Dietrich, KN; Hoofnagle, A; Lanphear, BP; Ospina, M; Percy, Z; Vuong, AM; Xie, C; Xu, Y; Yolton, K, 2021) |
| "Chlordecone is an endocrine-disrupting chemical with well recognized estrogenic and progestagenic properties." | 1.62 | ( Ayhan, G; Cordier, S; Costet, N; Giton, F; Kadhel, P; Michineau, L; Monfort, C; Multigner, L; Oliva, A; Rouget, F; Thomé, JP, 2021) |
| "Hippocampus-based learning and memory deficits are key symptoms of FASD." | 1.48 | Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin. ( Ferreira, A; Lim, PH; Redei, EE; Tunc-Ozcan, E; Wert, SL, 2018) |
| "Maternal hypothyroidism was associated with ASD for both boys (3." | 1.48 | Association between maternal hypothyroidism and autism spectrum disorders in children. ( Chiu, VY; Fassett, MJ; Getahun, D; Jacobsen, SJ; Peltier, MR; Wing, DA; Xiang, AH, 2018) |
| " By evaluating shape changes in the mandible among three age groups (15, 20 and 25 days postnatal) and different dosage levels (low, medium and high), this study found that excess maternal thyroxine alters offspring mandibular shape in both age- and dosage-dependent manners." | 1.48 | Maternal environment and craniofacial growth: geometric morphometric analysis of mandibular shape changes with in utero thyroxine overexposure in mice. ( Cray, JJ; Elsalanty, M; Howie, RN; Judd, MA; Kesterke, MJ; Mooney, MP; Siegel, MI; Weinberg, SM, 2018) |
| " To thoroughly investigate PFHxS toxicity in developing rats and to mimic a realistic human exposure situation, we examined a low dose close to human relevant PFHxS exposure, and combined the dose-response studies of PFHxS with a fixed dose of 12 environmentally relevant endocrine disrupting chemicals (EDmix)." | 1.48 | Perfluorohexane Sulfonate (PFHxS) and a Mixture of Endocrine Disrupters Reduce Thyroxine Levels and Cause Antiandrogenic Effects in Rats. ( Axelstad, M; Boberg, J; Christiansen, S; Hass, U; Nielsen, F; Ramhøj, L; Scholze, M, 2018) |
| "Subclinical hypothyroidism is caused by thyroid hormone deficit and can lead to impairments in mood and cognition." | 1.46 | Prenatal exposure to brain-specific anion transporter-1-specific monoclonal antibodies impairs cognitive function in post-natal life. ( Chekhonin, VP; Gurina, OI; Melnikov, PA; Morozova, AY; Zorkina, YA; Zubkov, EA, 2017) |
| "The neurodevelopmental fetal alcohol spectrum disorder (FASD) is characterized by cognitive and behavioral deficits in the offspring." | 1.43 | Thyroxine administration prevents matrilineal intergenerational consequences of in utero ethanol exposure in rats. ( Graf, EN; Harper, KM; Redei, EE; Tunc-Ozcan, E, 2016) |
| "Whether radioactive iodine treatment of Graves' disease (GD) during pregnancy will increase pregnancy loss and affect fetal development is still a matter of concern." | 1.43 | The preliminary clinical observation and analysis of childbearingage women with a history of iodine-131 treatment for Graves' disease. ( Chen, G; Guan, L; Wang, L; Zhang, J, 2016) |
| " Since an optimal study design for testing potential developmental neurotoxicants in rats, should include exposure during both the pre- and postnatal periods of brain development, we suggest that in the case of triclosan, direct dosing of pups may be the best way to obtain that goal." | 1.39 | Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring. ( Axelstad, M; Boberg, J; Christiansen, S; Hass, U; Vinggaard, AM, 2013) |
| "Expression of autism candidates, Gabrb3, Ube3a, Mecp2, and Slc25a12, was significantly increased in the hippocampus of male offspring of EtOH dams." | 1.39 | Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. ( Redei, EE; Shukla, PK; Tunc-Ozcan, E; Ullmann, TM, 2013) |
| " Groups of 14-18 pregnant Wistar rats were dosed with 0, 500, 750 or 1000 mg OMC/kg bw/day during gestation and lactation." | 1.37 | Effects of pre- and postnatal exposure to the UV-filter octyl methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring. ( Axelstad, M; Boberg, J; Christiansen, S; Hass, U; Hougaard, KS; Jacobsen, PR; Lund, SP; Mandrup, KR; Nellemann, C, 2011) |
| " Rats were perinatally dosed with a commercial PBDE mixture, DE-71." | 1.37 | Altered cardiovascular reactivity and osmoregulation during hyperosmotic stress in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs). ( Coburn, CG; Currás-Collazo, MC; Gaertner, M; Gillard, ER; Kodavanti, PR; Leon-Olea, M; Nichol, R; Shah, A; Shahidzadeh, A; Watson-Siriboe, A; Whitley, R, 2011) |
| " Female Long-Evans rats were dosed with corn oil vehicle, PCBs (3 or 6 mg/kg), molar equivalent doses of PBDEs (5." | 1.37 | Effects of developmental exposure to polychlorinated biphenyls and/or polybrominated diphenyl ethers on cochlear function. ( Ferguson, DC; McAlonan, RM; Poon, E; Powers, BE; Schantz, SL, 2011) |
| "Hypothyroidism was induced in pregnant and lactating rats by feeding 0." | 1.36 | Gestational and neonatal-onset hypothyroidism alters androgen receptor status in rat prostate glands at adulthood. ( Aruldhas, MM; Jaganathan, A; John Sashi, AM; Kannan, A; Nagappan, AS; Ramalingam, N; Seshadri, VN; Stanley, JA; Vasavan, J, 2010) |
| " Recent studies, indicating that even small changes in the mother's thyroid hormone status early in pregnancy may cause adverse effects on her child, have lead to increased concern for thyroid hormone disrupting chemicals in the environment." | 1.35 | Developmental neurotoxicity of propylthiouracil (PTU) in rats: relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes. ( Axelstad, M; Boberg, J; Bonnichsen, M; Hansen, PR; Hass, U; Hougaard, KS; Lund, SP; Nellemann, C, 2008) |
| " Pregnant Sprague-Dawley rats were dosed orally with 0." | 1.32 | Early developmental neurotoxicity of a PCB/organochlorine mixture in rodents after gestational and lactational exposure. ( Bowers, WJ; Chu, I; Gill, S; Meuller, R; Moir, D; Nakai, JS; Pulido, O; Wade, MG; Yagminas, A, 2004) |
| "Ammonium perchlorate (AP) is a powerful oxidizer manufactured almost exclusively for the aerospace industry." | 1.32 | In utero and lactational exposure of Long-Evans rats to ammonium perchlorate (AP) disrupts ovarian follicle maturation. ( Baldridge, MG; Gerstenberger, SL; Hutz, RJ; Stahl, RL; Tripoli, V, 2004) |
| " In the highest dosage groups (10 mg/kg for rat and 20 mg/kg for mouse), the neonates became pale, inactive, and moribund within 30-60 min, and all died soon afterward." | 1.32 | Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation. ( Butenhoff, JL; Grey, BE; Hanson, RG; Lau, C; Rogers, JM; Stanton, ME; Stevenson, LA; Thibodeaux, JR, 2003) |
| "Nitrofen treatment led to decreased plasma T3 and T4 levels without TSH changes." | 1.30 | Thyroid hormones in the pathogenesis of lung hypoplasia and immaturity induced in fetal rats by prenatal exposure to nitrofen. ( Alfonso, LF; Alvarez, FJ; Arnaiz, A; Diez-Pardo, JA; Morreale de Escobar, G; Qi, B; Tovar, JA; Valls-i-Soler, A, 1997) |
| "Metallothionein-3 (MT-3) is a brain specific member of the MT family." | 1.30 | Regulation of metallothionein-3 mRNA by thyroid hormone in developing rat brain and primary cultures of rat astrocytes and neurons. ( Fitch, CA; Horning, MS; Levenson, CW; Rutkoski, N; Yeiser, EC, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (5.19) | 18.7374 |
| 1990's | 30 (14.15) | 18.2507 |
| 2000's | 42 (19.81) | 29.6817 |
| 2010's | 114 (53.77) | 24.3611 |
| 2020's | 15 (7.08) | 2.80 |
| Authors | Studies |
|---|---|
| Rotem, RS | 1 |
| Chodick, G | 1 |
| Davidovitch, M | 1 |
| Bellavia, A | 1 |
| Weisskopf, MG | 1 |
| Siegel, EL | 1 |
| Kezios, KL | 2 |
| Houghton, L | 1 |
| Pereira-Eshraghi, C | 1 |
| Cirillo, P | 1 |
| Cohn, BA | 2 |
| Factor-Litvak, P | 3 |
| Ayhan, G | 1 |
| Rouget, F | 1 |
| Giton, F | 1 |
| Costet, N | 1 |
| Michineau, L | 1 |
| Monfort, C | 1 |
| Thomé, JP | 2 |
| Kadhel, P | 1 |
| Cordier, S | 1 |
| Oliva, A | 1 |
| Multigner, L | 1 |
| Lv, J | 1 |
| Li, Y | 1 |
| Chen, J | 3 |
| Li, R | 1 |
| Bao, C | 1 |
| Ding, Z | 1 |
| Ren, W | 1 |
| Du, Z | 1 |
| Wang, S | 2 |
| Huang, Y | 1 |
| Wang, QN | 1 |
| Ge, GM | 2 |
| Cheung, ECL | 2 |
| Man, KKC | 2 |
| Ip, P | 2 |
| Leung, WC | 2 |
| Li, GHY | 1 |
| Kung, AWC | 2 |
| Cheung, CL | 2 |
| Wong, ICK | 2 |
| Hales, C | 3 |
| Taylor, PN | 3 |
| Channon, S | 3 |
| McEwan, K | 2 |
| Thapar, A | 1 |
| Langley, K | 1 |
| Muller, I | 3 |
| Draman, MS | 3 |
| Dayan, C | 2 |
| Gregory, JW | 3 |
| Okosieme, O | 3 |
| Lazarus, JH | 6 |
| Rees, DA | 3 |
| Ludgate, M | 2 |
| Spann, MN | 1 |
| Cheslack-Postava, K | 1 |
| Brown, AS | 2 |
| Ramhøj, L | 2 |
| Hass, U | 5 |
| Gilbert, ME | 4 |
| Wood, C | 2 |
| Svingen, T | 1 |
| Usai, D | 1 |
| Vinggaard, AM | 2 |
| Mandrup, K | 1 |
| Axelstad, M | 5 |
| Daniel, RM | 1 |
| Scholz, A | 1 |
| Candler, T | 1 |
| Pettit, RJ | 1 |
| Evans, WD | 1 |
| Shillabeer, D | 1 |
| Dayan, CM | 1 |
| Tang, HKC | 1 |
| Ludgate, ME | 1 |
| Barlas, N | 1 |
| Göktekin, E | 1 |
| Karabulut, G | 1 |
| Zhou, Q | 1 |
| Wang, C | 1 |
| Xu, H | 1 |
| Li, X | 2 |
| Percy, Z | 1 |
| Vuong, AM | 1 |
| Xu, Y | 2 |
| Xie, C | 1 |
| Ospina, M | 1 |
| Calafat, AM | 2 |
| Hoofnagle, A | 2 |
| Lanphear, BP | 2 |
| Braun, JM | 2 |
| Cecil, KM | 1 |
| Dietrich, KN | 1 |
| Yolton, K | 2 |
| Chen, A | 3 |
| Irizar, A | 1 |
| Txintxurreta, A | 1 |
| Molinuevo, A | 1 |
| Jimeno-Romero, A | 1 |
| Anabitarte, A | 1 |
| Álvarez, JI | 1 |
| Martínez, MD | 1 |
| Santa-Marina, L | 1 |
| Ibarluzea, J | 1 |
| Lertxundi, A | 1 |
| Ribeiro, LGR | 1 |
| Silva, JF | 1 |
| Ocarino, NM | 1 |
| de Melo, EG | 1 |
| Serakides, R | 1 |
| Vrijkotte, TG | 3 |
| Hrudey, EJ | 1 |
| Twickler, MB | 1 |
| Durham, E | 1 |
| Howie, RN | 3 |
| Parsons, T | 1 |
| Bennfors, G | 2 |
| Black, L | 2 |
| Weinberg, SM | 3 |
| Elsalanty, M | 2 |
| Yu, JC | 2 |
| Cray, JJ | 3 |
| Oostenbroek, MHW | 1 |
| Kersten, RHJ | 1 |
| Tros, B | 1 |
| Kunst, AE | 1 |
| Vrijkotte, TGM | 1 |
| Finken, MJJ | 1 |
| Mohebbati, R | 1 |
| Hosseini, M | 1 |
| Haghshenas, M | 1 |
| Nazariborun, A | 1 |
| Beheshti, F | 1 |
| Zubkov, EA | 1 |
| Zorkina, YA | 1 |
| Gurina, OI | 1 |
| Melnikov, PA | 1 |
| Morozova, AY | 1 |
| Chekhonin, VP | 1 |
| Stagnaro-Green, A | 1 |
| Tunc-Ozcan, E | 4 |
| Wert, SL | 1 |
| Lim, PH | 1 |
| Ferreira, A | 1 |
| Redei, EE | 6 |
| Moog, NK | 1 |
| Heim, CM | 1 |
| Entringer, S | 1 |
| Kathmann, N | 1 |
| Wadhwa, PD | 1 |
| Buss, C | 1 |
| Hassan, I | 1 |
| El-Masri, H | 1 |
| Kosian, PA | 1 |
| Ford, J | 1 |
| Degitz, SJ | 1 |
| Huang, HB | 1 |
| Chuang, CJ | 1 |
| Su, PH | 3 |
| Sun, CW | 1 |
| Wang, CJ | 1 |
| Wu, MT | 1 |
| Wang, SL | 3 |
| Papandonatos, GD | 1 |
| Jackson-Browne, M | 1 |
| Hauser, R | 1 |
| Romano, ME | 1 |
| Karagas, MR | 1 |
| Thomas Zoeller, R | 1 |
| Getahun, D | 1 |
| Jacobsen, SJ | 1 |
| Fassett, MJ | 1 |
| Wing, DA | 1 |
| Xiang, AH | 1 |
| Chiu, VY | 1 |
| Peltier, MR | 1 |
| Thompson, W | 1 |
| Russell, G | 1 |
| Baragwanath, G | 1 |
| Matthews, J | 1 |
| Vaidya, B | 1 |
| Thompson-Coon, J | 1 |
| Paradice, R | 2 |
| Zhang, L | 2 |
| Gyedu, M | 1 |
| Bakhsh, A | 1 |
| Kawahori, K | 1 |
| Hashimoto, K | 1 |
| Yuan, X | 1 |
| Tsujimoto, K | 1 |
| Hanzawa, N | 1 |
| Hamaguchi, M | 1 |
| Kase, S | 1 |
| Fujita, K | 1 |
| Tagawa, K | 1 |
| Okazawa, H | 1 |
| Nakajima, Y | 1 |
| Shibusawa, N | 1 |
| Yamada, M | 1 |
| Ogawa, Y | 1 |
| Nelson, SM | 1 |
| Haig, C | 1 |
| McConnachie, A | 1 |
| Sattar, N | 1 |
| Ring, SM | 1 |
| Smith, GD | 1 |
| Lawlor, DA | 1 |
| Lindsay, RS | 1 |
| Preston, EV | 1 |
| Webster, TF | 1 |
| Oken, E | 2 |
| Claus Henn, B | 1 |
| McClean, MD | 1 |
| Rifas-Shiman, SL | 1 |
| Pearce, EN | 3 |
| Braverman, LE | 3 |
| Ye, X | 1 |
| Sagiv, SK | 1 |
| Boberg, J | 4 |
| Scholze, M | 1 |
| Christiansen, S | 3 |
| Nielsen, F | 1 |
| Andersen, SL | 1 |
| Andersen, S | 1 |
| Vestergaard, P | 1 |
| Olsen, J | 1 |
| Kesterke, MJ | 1 |
| Judd, MA | 1 |
| Mooney, MP | 1 |
| Siegel, MI | 1 |
| Levie, D | 1 |
| Korevaar, TIM | 1 |
| Bath, SC | 1 |
| Dalmau-Bueno, A | 1 |
| Murcia, M | 4 |
| Espada, M | 3 |
| Dineva, M | 1 |
| Ibarluzea, JM | 1 |
| Sunyer, J | 2 |
| Tiemeier, H | 9 |
| Rebagliato, M | 4 |
| Rayman, MP | 1 |
| Peeters, RP | 4 |
| Guxens, M | 1 |
| Haensgen, H | 1 |
| Albornoz, E | 1 |
| Opazo, MC | 2 |
| Bugueño, K | 1 |
| Jara Fernández, EL | 1 |
| Binzberger, R | 1 |
| Rivero-Castillo, T | 1 |
| Venegas Salas, LF | 1 |
| Simon, F | 1 |
| Cabello-Verrugio, C | 1 |
| Elorza, AA | 1 |
| Kalergis, AM | 2 |
| Bueno, SM | 2 |
| Riedel, CA | 2 |
| Fetene, DM | 2 |
| Betts, KS | 2 |
| Alati, R | 2 |
| Laureano-Melo, R | 1 |
| Souza, JS | 1 |
| da Conceição, RR | 1 |
| Albuquerque, JML | 1 |
| Rodrigues, NC | 1 |
| Marinho, BG | 1 |
| Olivares, EL | 1 |
| Giannocco, G | 1 |
| Côrtes, WDS | 1 |
| Howe, CG | 1 |
| Eckel, SP | 1 |
| Habre, R | 1 |
| Girguis, MS | 1 |
| Gao, L | 1 |
| Lurmann, FW | 1 |
| Gilliland, FD | 1 |
| Breton, CV | 1 |
| Nazarpour, S | 1 |
| Ramezani Tehrani, F | 1 |
| Sajedi, F | 1 |
| Bidhendi Yarandi, R | 1 |
| Azizi, F | 1 |
| Dong, J | 2 |
| Cong, Z | 1 |
| You, M | 1 |
| Fu, Y | 1 |
| Wang, Y | 6 |
| Fu, H | 1 |
| Wei, L | 1 |
| Liu, Z | 1 |
| Chen, Y | 1 |
| Chen, G | 2 |
| Mao, X | 1 |
| Wei, X | 1 |
| Jiang, F | 1 |
| Wang, K | 1 |
| Liu, C | 1 |
| Ji, H | 1 |
| Liang, H | 1 |
| Wang, Z | 1 |
| Miao, M | 1 |
| Wang, X | 2 |
| Zhang, X | 1 |
| Wen, S | 1 |
| Sun, X | 1 |
| Yuan, W | 1 |
| Päkkilä, F | 2 |
| Männistö, T | 2 |
| Surcel, HM | 3 |
| Ruokonen, A | 2 |
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| Pouta, A | 1 |
| Hartikainen, AL | 2 |
| Vääräsmäki, M | 2 |
| Järvelin, MR | 2 |
| Suvanto, E | 2 |
| Finken, MJ | 2 |
| van Eijsden, M | 2 |
| Loomans, EM | 2 |
| Rotteveel, J | 2 |
| Henrichs, J | 3 |
| Ghassabian, A | 8 |
| Slotkin, TA | 1 |
| Cooper, EM | 1 |
| Stapleton, HM | 2 |
| Seidler, FJ | 1 |
| Ullmann, TM | 1 |
| Shukla, PK | 2 |
| Román, GC | 3 |
| Bongers-Schokking, JJ | 4 |
| Jaddoe, VW | 6 |
| Hofman, A | 6 |
| de Rijke, YB | 4 |
| Verhulst, FC | 6 |
| Czerska, M | 1 |
| Zieliński, M | 1 |
| Kamińska, J | 1 |
| Ligocka, D | 1 |
| Tonyushkina, KN | 1 |
| Shen, MC | 1 |
| Ortiz-Toro, T | 1 |
| Karlstrom, RO | 1 |
| Harper, KM | 2 |
| Graf, EN | 2 |
| Sawicka-Gutaj, N | 1 |
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| Sowiński, J | 1 |
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| Czarnywojtek, A | 1 |
| Brązert, J | 1 |
| Ruchała, M | 1 |
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| Pinson, A | 1 |
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| Charlier, C | 1 |
| Zoeller, RT | 2 |
| Bourguignon, JP | 1 |
| Parent, AS | 1 |
| Kurtoglu, S | 1 |
| Bastug, O | 1 |
| Daar, G | 1 |
| Halis, H | 1 |
| Korkmaz, L | 1 |
| Memur, S | 1 |
| Korkut, S | 1 |
| Gunes, T | 1 |
| Ozturk, MA | 1 |
| El Marroun, H | 1 |
| White, T | 1 |
| Inoue, A | 1 |
| Arima, A | 1 |
| Kato, H | 1 |
| Yamashita, N | 1 |
| Nishida, Y | 1 |
| Ooshima, Y | 1 |
| Ebihara, S | 1 |
| Chang, K | 1 |
| Shin, JI | 1 |
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| McCloskey, DP | 1 |
| Goodman, JH | 1 |
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| Tan, L | 1 |
| Zhang, S | 1 |
| Dong, F | 1 |
| Chu, Z | 1 |
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| Zhao, N | 1 |
| Zhang, G | 1 |
| Yao, Z | 1 |
| Shen, J | 1 |
| Zhang, W | 1 |
| Furnica, RM | 1 |
| Gruson, D | 1 |
| Daumerie, C | 1 |
| O'Hare, E | 1 |
| Kim, EM | 1 |
| Page, D | 1 |
| Reid, R | 1 |
| Poon, E | 2 |
| Bandara, SB | 1 |
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| Zhao, Y | 1 |
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| Zhang, D | 2 |
| Ye, K | 1 |
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| Liu, Y | 2 |
| Hu, C | 1 |
| Ruan, L | 1 |
| Li, L | 1 |
| Tao, F | 1 |
| Guan, L | 1 |
| Zhang, J | 1 |
| Wang, L | 2 |
| Strobl, MJ | 1 |
| Freeman, D | 1 |
| Patel, J | 2 |
| Poulsen, R | 1 |
| Wendler, CC | 1 |
| Rivkees, SA | 1 |
| Coleman, JE | 1 |
| Minatoya, M | 1 |
| Naka Jima, S | 1 |
| Sasaki, S | 1 |
| Araki, A | 1 |
| Miyashita, C | 1 |
| Ikeno, T | 1 |
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| Kishi, R | 1 |
| Hirashima, R | 1 |
| Michimae, H | 1 |
| Takemoto, H | 1 |
| Sasaki, A | 1 |
| Kobayashi, Y | 1 |
| Itoh, T | 1 |
| Tukey, RH | 1 |
| Fujiwara, R | 1 |
| Schurmann, L | 1 |
| Hansen, AV | 1 |
| Garne, E | 1 |
| Özgür, E | 1 |
| Gürbüz Özgür, B | 1 |
| Aksu, H | 1 |
| Cesur, G | 1 |
| Feng, X | 1 |
| Cao, X | 1 |
| Zhao, S | 1 |
| Hua, X | 1 |
| Chen, L | 2 |
| Lv, PP | 1 |
| Tian, S | 1 |
| Feng, C | 1 |
| Li, JY | 1 |
| Yu, DQ | 1 |
| Jin, L | 1 |
| Shen, Y | 1 |
| Yu, TT | 1 |
| Meng, Y | 1 |
| Ding, GL | 1 |
| Jin, M | 1 |
| Chen, XJ | 1 |
| Sheng, JZ | 1 |
| Huang, HF | 1 |
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| Colombier, M | 1 |
| Mulliez, A | 1 |
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| Gallot, D | 1 |
| Durham, EL | 1 |
| Parsons, TE | 1 |
| Elsalanty, ME | 1 |
| Chevrier, J | 1 |
| Eskenazi, B | 1 |
| Holland, N | 1 |
| Bradman, A | 1 |
| Barr, DB | 1 |
| Gianini, A | 1 |
| Pancetti, F | 1 |
| Azkcona, G | 1 |
| Alarcón, L | 1 |
| Lizana, R | 1 |
| Noches, V | 1 |
| Gonzalez, PA | 1 |
| Marassi, MP | 1 |
| Porto, M | 1 |
| Mora, S | 1 |
| Rosenthal, D | 1 |
| Eugenin, E | 1 |
| Naranjo, D | 1 |
| Hansen, PR | 1 |
| Bonnichsen, M | 1 |
| Nellemann, C | 2 |
| Lund, SP | 2 |
| Hougaard, KS | 2 |
| Kobayashi, K | 3 |
| Miyagawa, M | 2 |
| Wang, RS | 2 |
| Suda, M | 2 |
| Sekiguchi, S | 2 |
| Honma, T | 2 |
| Platek, D | 1 |
| Mitchell, ML | 1 |
| Lee, SL | 1 |
| Blumenfeld, Z | 1 |
| Kawaguchi, M | 1 |
| Morohoshi, K | 1 |
| Saita, E | 1 |
| Yanagisawa, R | 1 |
| Watanabe, G | 1 |
| Takano, H | 1 |
| Morita, M | 1 |
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| Taya, K | 1 |
| Himi, T | 1 |
| Vujovic, M | 1 |
| Nordström, K | 1 |
| Gauthier, K | 1 |
| Flamant, F | 1 |
| Visser, TJ | 4 |
| Vennström, B | 1 |
| Mittag, J | 1 |
| Lopez-Espinosa, MJ | 1 |
| Vizcaino, E | 1 |
| Llop, S | 1 |
| Seco, V | 1 |
| Marco, A | 1 |
| Grimalt, JO | 1 |
| Ballester, F | 1 |
| Berbel, P | 1 |
| Mestre, JL | 1 |
| Santamaría, A | 1 |
| Palazón, I | 1 |
| Franco, A | 1 |
| Graells, M | 1 |
| González-Torga, A | 1 |
| de Escobar, GM | 1 |
| Glinoer, D | 1 |
| Rovet, J | 1 |
| Chang, SC | 1 |
| Ehresman, DJ | 1 |
| Bjork, JA | 1 |
| Wallace, KB | 1 |
| Parker, GA | 1 |
| Stump, DG | 1 |
| Butenhoff, JL | 2 |
| Dallaire, R | 1 |
| Muckle, G | 1 |
| Dewailly, E | 1 |
| Jacobson, SW | 1 |
| Jacobson, JL | 1 |
| Sandanger, TM | 1 |
| Sandau, CD | 1 |
| Ayotte, P | 1 |
| Anselmo, CW | 1 |
| Pereira, PB | 1 |
| Catanho, MT | 1 |
| Medeiros, MC | 1 |
| Haviland, JA | 1 |
| Butz, DE | 1 |
| Porter, WP | 1 |
| Sittig, LJ | 1 |
| Andrus, BM | 1 |
| Schaffer, DJ | 1 |
| Batra, KK | 1 |
| Aruldhas, MM | 1 |
| Ramalingam, N | 1 |
| Jaganathan, A | 1 |
| John Sashi, AM | 1 |
| Stanley, JA | 1 |
| Nagappan, AS | 1 |
| Vasavan, J | 1 |
| Kannan, A | 1 |
| Seshadri, VN | 1 |
| Chen, JW | 1 |
| El-Bakry, AM | 1 |
| El-Gareib, AW | 1 |
| Ahmed, RG | 1 |
| Kini, U | 1 |
| Hurst, JA | 1 |
| Byren, JC | 1 |
| Wall, SA | 1 |
| Johnson, D | 1 |
| Wilkie, AO | 1 |
| Liu, D | 1 |
| Shan, Z | 2 |
| Yu, X | 1 |
| Gao, Y | 1 |
| Fan, C | 2 |
| Wang, H | 2 |
| Zhang, H | 2 |
| Rooke, JA | 1 |
| Houdijk, JG | 1 |
| McIlvaney, K | 1 |
| Ashworth, CJ | 1 |
| Dwyer, CM | 1 |
| Miller, VM | 1 |
| Kahnke, T | 1 |
| Neu, N | 1 |
| Sanchez-Morrissey, SR | 1 |
| Brosch, K | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preconceptional Thyroid Screening and Childhood Nerocognitive Function[NCT01744743] | 600 participants (Anticipated) | Interventional | 2011-01-31 | Recruiting | |||
| Study on the Compensatory Mechanism of Iodine Nutrition and the Optimal Intake Level of Lactating Women[NCT04492657] | 600 participants (Anticipated) | Observational | 2020-01-01 | Recruiting | |||
| Iodine Nutrition During Pregnancy and Related Neonatal Physical Development[NCT02586220] | 250 participants (Actual) | Observational | 2015-08-31 | Completed | |||
| Randomized Thyroid Screening Protocol During Pregnancy: a Multi-center Prospective Controlled Study[NCT01838031] | 1,000 participants (Anticipated) | Interventional | 2011-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for thyroxine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis.
Topics: Female; Humans; Hypothyroidism; Neurodevelopmental Disorders; Pregnancy; Pregnancy Complications; Pr | 2018 |
Thyroid Function in Early Pregnancy, Child IQ, and Autistic Traits: A Meta-Analysis of Individual Participant Data.
Topics: Adult; Autistic Disorder; Child; Child Development; Child, Preschool; Female; Gestational Age; Human | 2018 |
Maternal hypothyroxinemia and effects on cognitive functioning in childhood: how and why?
Topics: Brain; Child; Cognition; Female; Humans; Iodine; Pregnancy; Pregnancy Complications; Prenatal Exposu | 2013 |
Effects of polybrominated diphenyl ethers on thyroid hormone, neurodevelopment and fertility in rodents and humans.
Topics: Animals; Endocrine Disruptors; Female; Fertility; Flame Retardants; Genitalia, Male; Halogenated Dip | 2013 |
Influence of cigarette smoking on thyroid gland--an update.
Topics: Female; Graves Disease; Hashimoto Disease; Humans; Hyperthyroidism; Hypothyroidism; Pregnancy; Pregn | 2014 |
Impact of mild thyroid hormone deficiency in pregnancy on cognitive function in children: lessons from the Generation R Study.
Topics: Child, Preschool; Cognition; Cohort Studies; Executive Function; Female; Fetal Blood; Head; Humans; | 2014 |
Update on a new controversy in endocrinology: isolated maternal hypothyroxinemia.
Topics: Animals; Biomarkers; Endocrinology; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complicati | 2015 |
Maternal Hypothyroxinemia-Induced Neurodevelopmental Impairments in the Progeny.
Topics: Brain; Cohort Studies; Endocrine Disruptors; Female; Forecasting; Humans; Infant, Newborn; Infant, P | 2016 |
The effects of PCBs and dioxins on child health.
Topics: Child; Child Welfare; Dioxins; Environmental Exposure; Environmental Health; Environmental Monitorin | 2006 |
Thyroid hormones, learning and memory.
Topics: Animals; Cognition; Disease Models, Animal; Female; Humans; Learning; Memory; Mice; Mice, Transgenic | 2007 |
Thyroid hormone and intellectual development: a clinician's view.
Topics: Brain; Congenital Hypothyroidism; Developmental Disabilities; Female; Humans; Infant, Newborn; Intel | 1999 |
Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?
Topics: Animals; Child; Child Development; Child, Preschool; Developmental Disabilities; Female; Humans; Hyp | 2000 |
6 trials available for thyroxine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Controlled Antenatal Thyroid Screening II: Effect of Treating Maternal Suboptimal Thyroid Function on Child Behavior.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Biomarkers; Case-Control Studies; Child; Child | 2020 |
Second trimester levothyroxine treatment for subclinical hypothyroidism or hypothyroxinaemia of pregnancy does not improve cognitive outcomes of children.
Topics: Child, Preschool; Cognition; Evidence-Based Medicine; Female; Humans; Hypothyroidism; Intelligence; | 2017 |
Evaluation of the impact of levothyroxine treatment on the psychomotor developmental status of three-year-old children born to mothers with mild thyroid impairment; Tehran Thyroid and pregnancy study: study protocol for a randomized clinical trial.
Topics: Age Factors; Asymptomatic Diseases; Child Behavior; Child Development; Child, Preschool; Female; Hum | 2019 |
Maternal hypothyroxinemia in early pregnancy predicts reduced performance in reaction time tests in 5- to 6-year-old offspring.
Topics: Child; Child of Impaired Parents; Child, Preschool; Cognition; Congenital Hypothyroidism; Female; Ge | 2013 |
Differential effects of maternal undernutrition between days 1 and 90 of pregnancy on ewe and lamb performance and lamb parasitism in hill or lowland breeds.
Topics: Animal Nutritional Physiological Phenomena; Animals; Breeding; Female; Genetic Predisposition to Dis | 2010 |
Antenatal thyroid screening and childhood cognitive function.
Topics: Child, Preschool; Female; Gestational Age; Humans; Hypothyroidism; Intellectual Disability; Intellig | 2012 |
194 other studies available for thyroxine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Maternal Thyroid Anomalies and Attention-Deficit Hyperactivity Disorder in Progeny.
Topics: Attention Deficit Disorder with Hyperactivity; Female; Humans; Mothers; Pregnancy; Prenatal Exposure | 2022 |
Could maternal thyroid function during pregnancy affect daughters' age at menarche through child growth? A mediation analysis.
Topics: Adolescent; Adult; Autoantibodies; Child; Child Development; Child, Preschool; Female; Humans; Menar | 2022 |
Topics: Adiponectin; Child; Chlordecone; Dehydroepiandrosterone; Dihydrotestosterone; Environmental Exposure | 2021 |
Maternal exposure to bis(2-ethylhexyl) phthalate during the thyroid hormone-dependent stage induces persistent emotional and cognitive impairment in middle-aged offspring mice.
Topics: Animals; Cognitive Dysfunction; Diethylhexyl Phthalate; Female; Humans; Male; Maternal Exposure; Mic | 2022 |
Association of maternal levothyroxine use during pregnancy with offspring birth and neurodevelopmental outcomes: a population-based cohort study.
Topics: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Cohort Studies; Female; Hum | 2022 |
Levothyroxine Treatment Among Pregnant Women and Risk of Seizure in Children: A Population-Based Cohort Study.
Topics: Cohort Studies; Female; Hong Kong; Humans; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effe | 2023 |
The association of serologically documented maternal thyroid conditions during pregnancy with bipolar disorder in offspring.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Child; Congenital Hypothyroidism; Family; Female; Hum | 2020 |
Evaluating thyroid hormone disruption: investigations of long-term neurodevelopmental effects in rats after perinatal exposure to perfluorohexane sulfonate (PFHxS).
Topics: Animals; Embryonic Development; Endocrine Disruptors; Female; Fluorocarbons; Gene Expression Regulat | 2020 |
CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers.
Topics: Absorptiometry, Photon; Adiponectin; Anthropometry; Blood Pressure; Body Composition; Body Mass Inde | 2020 |
Influence of
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Endocrine Glands; Female; Male; Organ Size; | 2020 |
Impact of Preconception Treatment Initiation for Hypothyroidism on Neurocognitive Function in Children.
Topics: Child Development; Child, Preschool; Cognition; Female; Humans; Hypothyroidism; Infant; Male; Motor | 2020 |
Maternal Urinary Organophosphate Esters and Alterations in Maternal and Neonatal Thyroid Hormones.
Topics: Adolescent; Adult; Environmental Exposure; Female; Fetal Blood; Flame Retardants; Humans; Infant, Ne | 2021 |
Association between prenatal exposure to air pollutants and newborn thyroxine (T4) levels.
Topics: Air Pollutants; Air Pollution; Child; Female; Humans; Infant; Infant, Newborn; Maternal Exposure; Pa | 2021 |
Excess maternal and postnatal thyroxine alters chondrocyte numbers and the composition of the extracellular matrix of growth cartilage in rats.
Topics: Animals; Cartilage; Cell Proliferation; Chondrocytes; Extracellular Matrix; Female; Femur; Gene Expr | 2018 |
Early Maternal Thyroid Function During Gestation Is Associated With Fetal Growth, Particularly in Male Newborns.
Topics: Adult; Asymptomatic Diseases; Autoantibodies; Birth Weight; Cohort Studies; Female; Fetal Macrosomia | 2017 |
Thyroxine Exposure Effects on the Cranial Base.
Topics: Animals; Female; Male; Mice; Mice, Inbred C57BL; Pregnancy; Prenatal Exposure Delayed Effects; Skull | 2017 |
Maternal hypothyroxinaemia in early pregnancy and problem behavior in 5-year-old offspring.
Topics: Adult; Child, Preschool; Female; Gestational Age; Humans; Longitudinal Studies; Male; Mothers; Pregn | 2017 |
Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats.
Topics: Animals; Animals, Newborn; Antithyroid Agents; Blood Urea Nitrogen; Catalase; Creatinine; Female; Hy | 2017 |
Prenatal exposure to brain-specific anion transporter-1-specific monoclonal antibodies impairs cognitive function in post-natal life.
Topics: Animals; Antibodies, Monoclonal; Blood-Brain Barrier; Brain; Cognition; Female; Hypothyroidism; Male | 2017 |
Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin.
Topics: Alcohol Drinking; Alleles; Animals; Ethanol; Fear; Female; Fetal Alcohol Spectrum Disorders; Hippoca | 2018 |
Childhood maltreatment is associated with increased risk of subclinical hypothyroidism in pregnancy.
Topics: Adult; Cohort Studies; Female; Humans; Hypothyroidism; Life Change Events; Mothers; Pregnancy; Pregn | 2017 |
Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework.
Topics: Adverse Outcome Pathways; Animals; Biomarkers; Brain; Computer Simulation; Dose-Response Relationshi | 2017 |
Prenatal and Childhood Exposure to Phthalate Diesters and Thyroid Function in a 9-Year Follow-up Birth Cohort Study: Taiwan Maternal and Infant Cohort Study.
Topics: Adult; Child; Child, Preschool; Cohort Studies; Diethylhexyl Phthalate; Environmental Exposure; Fema | 2017 |
Associations of early life urinary triclosan concentrations with maternal, neonatal, and child thyroid hormone levels.
Topics: Adolescent; Adult; Child, Preschool; Cohort Studies; Female; Humans; Infant; Infant, Newborn; Male; | 2018 |
Association between maternal hypothyroidism and autism spectrum disorders in children.
Topics: Adolescent; Age Factors; Autism Spectrum Disorder; Child; Child, Preschool; Female; Humans; Hypothyr | 2018 |
Controlled Antenatal Thyroid Screening II: Effect of Treating Maternal Suboptimal Thyroid Function on Child Cognition.
Topics: Adult; Child; Cognition; Female; Humans; Hypothyroidism; Intelligence; Intelligence Tests; Male; Pre | 2018 |
Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; DNA Methylation; Female; Hippocampus; | 2018 |
Maternal thyroid function and child educational attainment: prospective cohort study.
Topics: Adolescent; Child; Child, Preschool; Educational Status; Female; Humans; Intelligence; Iodide Peroxi | 2018 |
Maternal Plasma per- and Polyfluoroalkyl Substance Concentrations in Early Pregnancy and Maternal and Neonatal Thyroid Function in a Prospective Birth Cohort: Project Viva (USA).
Topics: Adult; Boston; Cohort Studies; Environmental Exposure; Female; Fluorocarbons; Humans; Infant, Newbor | 2018 |
Perfluorohexane Sulfonate (PFHxS) and a Mixture of Endocrine Disrupters Reduce Thyroxine Levels and Cause Antiandrogenic Effects in Rats.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Endocrine Disrupt | 2018 |
Maternal Thyroid Function in Early Pregnancy and Child Neurodevelopmental Disorders: A Danish Nationwide Case-Cohort Study.
Topics: Adult; Child; Child, Preschool; Denmark; Female; Fetal Development; Humans; Infant; Male; Neurodevel | 2018 |
Maternal environment and craniofacial growth: geometric morphometric analysis of mandibular shape changes with in utero thyroxine overexposure in mice.
Topics: Animals; Facial Bones; Female; Male; Mandible; Mice; Mice, Inbred C57BL; Pregnancy; Prenatal Exposur | 2018 |
Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis.
Topics: Adoptive Transfer; Animals; Biomarkers; Cell Differentiation; Cytokines; Encephalomyelitis, Autoimmu | 2018 |
Maternal Prenatal Thyroid Function and Offspring ADHD: Findings From the ALSPAC Cohort.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Child; Female; Humans; Iodide Pero | 2018 |
Prenatal thyroxine treatment promotes anxiolysis in male Swiss mice offspring.
Topics: Affect; Animals; Anti-Anxiety Agents; Anxiety; Female; Hippocampus; Hyperthyroidism; Male; Maze Lear | 2019 |
Association of Prenatal Exposure to Ambient and Traffic-Related Air Pollution With Newborn Thyroid Function: Findings From the Children's Health Study.
Topics: Air Pollutants; Air Pollution; California; Cohort Studies; Environmental Exposure; Female; Fetal Dev | 2018 |
The role of maternal prenatal thyroid function on offspring depression: Findings from the ALSPAC cohort.
Topics: Adolescent; Adult; Anxiety; Child; Cohort Studies; Depression; Female; Humans; Longitudinal Studies; | 2020 |
Effects of perinatal di (2-ethylhexyl) phthalate exposure on thyroid function in rat offspring.
Topics: Animals; Diethylhexyl Phthalate; DNA-Binding Proteins; Endocrine Disruptors; Female; Iodide Peroxida | 2019 |
Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Cell Proliferation; Disease Models, Animal; Female; | 2019 |
Associations of prenatal exposures to low levels of Polybrominated Diphenyl Ether (PBDE) with thyroid hormones in cord plasma and neurobehavioral development in children at 2 and 4 years.
Topics: Child, Preschool; China; Cohort Studies; Female; Fetal Blood; Halogenated Diphenyl Ethers; Humans; I | 2019 |
Maternal thyroid dysfunction during pregnancy and thyroid function of her child in adolescence.
Topics: Adolescent; Autoantibodies; Female; Finland; Follow-Up Studies; Humans; Hyperthyroidism; Hypothyroid | 2013 |
Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?
Topics: Age Factors; Animals; Brain; Chlorpyrifos; Female; Gestational Age; Insecticides; Male; Maternal Exp | 2013 |
Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression.
Topics: Animals; Autistic Disorder; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Hippocampus; Male; Pr | 2013 |
Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring.
Topics: Animals; Animals, Newborn; Anti-Infective Agents, Local; Brain; Dose-Response Relationship, Drug; En | 2013 |
Association of gestational maternal hypothyroxinemia and increased autism risk.
Topics: Adult; Autistic Disorder; Child; Child, Preschool; Female; Gestational Age; Humans; Hypothyroidism; | 2013 |
Embryonic exposure to excess thyroid hormone causes thyrotrope cell death.
Topics: Animals; Animals, Genetically Modified; Apoptosis; Cell Differentiation; Congenital Hypothyroidism; | 2014 |
Intergenerational effects of prenatal ethanol on glucose tolerance and insulin response.
Topics: Animals; Blood Glucose; Body Weight; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Glucose Tole | 2014 |
Alteration of rat fetal cerebral cortex development after prenatal exposure to polychlorinated biphenyls.
Topics: Animals; Cell Cycle; Cell Death; Cell Differentiation; Cell Movement; Cell Proliferation; Cerebral C | 2014 |
Reply: To PMID 23943579.
Topics: Autistic Disorder; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Complications; Prenatal Expo | 2014 |
Effect of iodine loading on the thyroid hormone level of newborns living in Kayseri province.
Topics: Anti-Infective Agents, Local; Female; Humans; Hypothyroidism; Infant, Newborn; Iodine; Male; Milk, H | 2014 |
Downstream effects of maternal hypothyroxinemia in early pregnancy: nonverbal IQ and brain morphology in school-age children.
Topics: Brain; Case-Control Studies; Child; Child Development; Cohort Studies; Female; Humans; Hypothyroidis | 2014 |
Effects of maternal exposure to thiamazole on behavioral development in infant cynomolgus monkeys.
Topics: Animals; Animals, Newborn; Antithyroid Agents; Behavior, Animal; Female; Macaca fascicularis; Matern | 2013 |
Association of gestational maternal hypothyroxinemia and increased autism risk: the role of brain-derived neurotrophic factor.
Topics: Autistic Disorder; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Complications; Prenatal Expo | 2014 |
Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics.
Topics: Animals; Brain; Classical Lissencephalies and Subcortical Band Heterotopias; Dose-Response Relations | 2014 |
Neonatal thyroid function born to mothers living with long-term excessive iodine intake from drinking water.
Topics: Adult; China; Cross-Sectional Studies; Drinking Water; Female; Fetal Blood; Geography; Humans; Infan | 2015 |
Effects of thyroxine treatment on histology and behavior using the methimazole model of congenital hypothyroidism in the rat.
Topics: Animals; Conditioning, Operant; Congenital Hypothyroidism; Dendrites; Disease Models, Animal; Female | 2015 |
Developmental PCB exposure increases susceptibility to audiogenic seizures in adulthood.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Cohort Studies; Disease Susceptibility; Dose-Respon | 2015 |
Maternal thyroid dysfunction during gestation, preterm delivery, and birthweight. The Infancia y Medio Ambiente Cohort, Spain.
Topics: Adult; Birth Weight; Female; Gestational Age; Humans; Hypothyroidism; Infant, Newborn; Iodine; Mothe | 2015 |
Developmental immunotoxicity testing of 4-methyl anisole.
Topics: Animals; Animals, Newborn; Anisoles; Cytokines; Eosinophils; Female; Immunoglobulin G; Immunologic F | 2015 |
Thyroid and growth hormone concentrations in 8-year-old children exposed in utero to dioxins and polychlorinated biphenyls.
Topics: Child; Dioxins; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Humans; Insulin- | 2015 |
Effect of gestational subclinical hypothyroidism on early neurodevelopment of offspring.
Topics: Adult; Behavior Rating Scale; China; Female; Humans; Hypothyroidism; Infant; Infant, Newborn; Intell | 2015 |
Maternal Mild Thyroid Hormone Insufficiency in Early Pregnancy and Attention-Deficit/Hyperactivity Disorder Symptoms in Children.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Child; Female; Follow-Up Studies; Gestational | 2015 |
Hypothyroxinemia During Gestation and Offspring Schizophrenia in a National Birth Cohort.
Topics: Adolescent; Adult; Case-Control Studies; Child; Cohort Studies; Female; Finland; Gestational Age; Hu | 2016 |
Maternal hypothyroxinaemia in early pregnancy and school performance in 5-year-old offspring.
Topics: Adult; Child Development; Child, Preschool; Educational Measurement; Female; Humans; Hypothyroidism; | 2015 |
Maternal and Child's Thyroid Function and Child's Intellect and Scholastic Performance.
Topics: Achievement; Adolescent; Adult; Autoantibodies; Child; Child Development; Cohort Studies; Female; Fi | 2015 |
Effects of Maternal Iodine Nutrition and Thyroid Status on Cognitive Development in Offspring: A Pilot Study.
Topics: Adult; Child; Cognition; Dietary Supplements; Female; Humans; Intelligence Tests; Iodine; Maternal N | 2016 |
Mild Thyroid Hormone Insufficiency During Development Compromises Activity-Dependent Neuroplasticity in the Hippocampus of Adult Male Rats.
Topics: Animals; Antithyroid Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Conditioning, Psyc | 2016 |
Placental Transfer of Perfluoroalkyl Substances and Associations with Thyroid Hormones: Beijing Prenatal Exposure Study.
Topics: Adult; Beijing; Caprylates; Decanoic Acids; Environmental Pollutants; Female; Fetal Blood; Fetus; Fl | 2016 |
Thyroxine administration prevents matrilineal intergenerational consequences of in utero ethanol exposure in rats.
Topics: Alcohol Drinking; Animals; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Hippocampus; Hypothyro | 2016 |
Physiological and behavioral responses in offspring mice following maternal exposure to sulfamonomethoxine during pregnancy.
Topics: Animals; Anti-Infective Agents; Anxiety; Behavior, Animal; Blood Glucose; Body Weight; Brain-Derived | 2016 |
The preliminary clinical observation and analysis of childbearingage women with a history of iodine-131 treatment for Graves' disease.
Topics: Abortion, Spontaneous; Adult; Female; Fetal Development; Graves Disease; Humans; Iodine Radioisotope | 2016 |
Opposing Effects of Maternal Hypo- and Hyperthyroidism on the Stability of Thalamocortical Synapses in the Visual Cortex of Adult Offspring.
Topics: Adult; Animals; Animals, Newborn; Antithyroid Agents; Brain Mapping; Disease Models, Animal; Female; | 2017 |
Effects of prenatal phthalate exposure on thyroid hormone levels, mental and psychomotor development of infants: The Hokkaido Study on Environment and Children's Health.
Topics: Child Health; Diethylhexyl Phthalate; Environmental Pollutants; Female; Humans; Infant; Infant, Newb | 2016 |
Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity.
Topics: Animals; Animals, Newborn; Brain; Carbamazepine; Cell Movement; Enzyme Induction; Female; Gene Expre | 2016 |
Pregnancy outcomes after fetal exposure to antithyroid medications or levothyroxine.
Topics: Adult; Birth Weight; Case-Control Studies; Congenital Abnormalities; Denmark; Female; Humans; Infant | 2016 |
The Effect of Congenital and Postnatal Hypothyroidism on Depression-Like Behaviors in Juvenile Rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Congenital Hypothyroidism; Depression; | 2016 |
Exposure of Pregnant Mice to Perfluorobutanesulfonate Causes Hypothyroxinemia and Developmental Abnormalities in Female Offspring.
Topics: Abnormalities, Drug-Induced; Animals; Congenital Hypothyroidism; Estrogens; Female; Fluorocarbons; G | 2017 |
Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring.
Topics: Animals; CpG Islands; Disease Models, Animal; DNA Methylation; Estradiol; Female; Genetic Markers; M | 2016 |
[Iodinated contrast in pregnant women and neonatal thyroid function].
Topics: Congenital Hypothyroidism; Contrast Media; Female; Gestational Age; Humans; Infant, Newborn; Iodine; | 2016 |
Effects of In Utero Thyroxine Exposure on Murine Cranial Suture Growth.
Topics: Animals; Cranial Sutures; Female; High-Temperature Requirement A Serine Peptidase 1; Insulin-Like Gr | 2016 |
Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy.
Topics: Adolescent; Adult; Biomarkers; California; Cohort Studies; Dichlorodiphenyl Dichloroethylene; Enviro | 2008 |
Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring.
Topics: Age Factors; Animals; Cognition Disorders; Disks Large Homolog 4 Protein; Female; Hypothyroidism; Im | 2008 |
Developmental neurotoxicity of propylthiouracil (PTU) in rats: relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes.
Topics: Age Factors; Animals; Animals, Newborn; Antithyroid Agents; Auditory Threshold; Behavior, Animal; Bo | 2008 |
Effects of in utero exposure to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) on somatic growth and endocrine status in rat offspring.
Topics: Animals; Animals, Newborn; Female; Growth Hormone; Insulin-Like Growth Factor I; Male; Organ Size; P | 2008 |
Neonatal thyroxine, maternal thyroid function, and child cognition.
Topics: Adult; Autoantibodies; Child Development; Child, Preschool; Cognition; Cohort Studies; Diet; Female; | 2009 |
Maternal thyroid hypofunction and pregnancy outcome.
Topics: Child; Developmental Disabilities; Female; Follow-Up Studies; Hormone Replacement Therapy; Humans; H | 2008 |
Developmental exposure to pentachlorophenol affects the expression of thyroid hormone receptor beta1 and synapsin I in brain, resulting in thyroid function vulnerability in rats.
Topics: Adrenal Glands; Animals; Cerebral Cortex; Corticosterone; Female; Hypertrophy; Lactation; Male; Neur | 2008 |
Interference of a mutant thyroid hormone receptor alpha1 with hepatic glucose metabolism.
Topics: Animals; Down-Regulation; Fasting; Female; Glucose; Glycogen; Liver; Male; Mice; Mice, Inbred C57BL; | 2009 |
Association between thyroid hormone levels and 4,4'-DDE concentrations in pregnant women (Valencia, Spain).
Topics: Adolescent; Adult; Biomarkers; Cohort Studies; Dichlorodiphenyl Dichloroethylene; Female; Fetal Deve | 2009 |
Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation.
Topics: Child Development; Deficiency Diseases; Dietary Supplements; Drug Administration Schedule; Female; G | 2009 |
Effects of in utero exposure to 2,2',4,4',5,5'-hexachlorobiphenyl on postnatal development and thyroid function in rat offspring.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Environmental Monitoring; Female; Growth and | 2009 |
Gestational hypothyroxinemia and the beneficial effects of early dietary iodine fortification.
Topics: Child Development; Deficiency Diseases; Dietary Supplements; Drug Administration Schedule; Female; G | 2009 |
Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression.
Topics: Alkanesulfonic Acids; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Environmental Pol | 2009 |
Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants.
Topics: Adult; Environmental Exposure; Environmental Pollutants; Female; Hexachlorobenzene; Humans; Infant; | 2009 |
Effects of the electromagnetic field, 60 Hz, 3 microT, on the hormonal and metabolic regulation of undernourished pregnant rats.
Topics: Animals; Electromagnetic Fields; Female; Hydrocortisone; Insulin; Pregnancy; Prenatal Exposure Delay | 2009 |
Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero.
Topics: Animals; Behavior, Animal; Chlorpyrifos; Female; Gestational Age; Insecticides; Male; Mice; Pregnanc | 2010 |
Prenatal thyroxine treatment disparately affects peripheral and amygdala thyroid hormone levels.
Topics: Amygdala; Animals; Anxiety; Corticosterone; Corticotropin-Releasing Hormone; Depressive Disorder; Di | 2010 |
Gestational and neonatal-onset hypothyroidism alters androgen receptor status in rat prostate glands at adulthood.
Topics: Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Estradiol; Female; Hypothyroidis | 2010 |
Growth and thyroid function in children with in utero exposure to dioxin: a 5-year follow-up study.
Topics: Age Factors; Aging; Benzofurans; Body Height; Body Mass Index; Body Weight; Bone Development; Cephal | 2010 |
Comparative study of the effects of experimentally induced hypothyroidism and hyperthyroidism in some brain regions in albino rats.
Topics: Animals; Antithyroid Agents; Brain; Cell Differentiation; Disease Models, Animal; Female; Humans; Hy | 2010 |
Etiological heterogeneity and clinical characteristics of metopic synostosis: Evidence from a tertiary craniofacial unit.
Topics: Adolescent; Anticoagulants; Child; Child, Preschool; Chromosome Aberrations; Craniosynostoses; Enoxa | 2010 |
The effect of maternal subclinical hypothyroidism during pregnancy on brain development in rat offspring.
Topics: Animals; Brain; Disease Models, Animal; Female; Hippocampus; Hypothyroidism; Maze Learning; Pregnanc | 2010 |
Developmental PCB exposure induces hypothyroxinemia and sex-specific effects on cerebellum glial protein levels in rats.
Topics: Animals; Cerebellum; Environmental Pollutants; Female; Glial Fibrillary Acidic Protein; Humans; Inte | 2010 |
Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep.
Topics: Animals; Blood Glucose; Estrogens; Female; Gene Expression Regulation; Insulin; Insulin-Like Growth | 2011 |
Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats.
Topics: Animals; Female; Humans; Models, Animal; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, L | 2010 |
In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.
Topics: Animals; Animals, Newborn; Body Weight; Complex Mixtures; Cytochrome P-450 CYP1A2; Environmental Pol | 2011 |
Effects of pre- and postnatal exposure to the UV-filter octyl methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring.
Topics: Animals; Behavior, Animal; Cinnamates; Dose-Response Relationship, Drug; Endocrine Disruptors; Estra | 2011 |
Delivery of maternal thyroid hormones to the fetus.
Topics: Female; Gestational Age; Humans; Iodide Peroxidase; Maternal-Fetal Exchange; Placenta; Prealbumin; P | 2011 |
Interaction of PFOS and BDE-47 co-exposure on thyroid hormone levels and TH-related gene and protein expression in developing rat brains.
Topics: Alkanesulfonic Acids; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Drug Interaction | 2011 |
Maternal thyroid function during pregnancy and behavioral problems in the offspring: the generation R study.
Topics: Adult; Age Factors; Aggression; Attention; Checklist; Chi-Square Distribution; Child Behavior; Child | 2011 |
Altered cardiovascular reactivity and osmoregulation during hyperosmotic stress in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs).
Topics: Age Factors; Animals; Animals, Newborn; Blood Pressure; Dose-Response Relationship, Drug; Female; Ha | 2011 |
Effects of developmental exposure to polychlorinated biphenyls and/or polybrominated diphenyl ethers on cochlear function.
Topics: Animals; Cochlea; Dose-Response Relationship, Drug; Drug Synergism; Female; Halogenated Diphenyl Eth | 2011 |
Cord blood thyroid tests in boys born with and without cryptorchidism: correlations with birth parameters and in utero xenobiotics exposure.
Topics: Case-Control Studies; Cryptorchidism; Dichlorodiphenyl Dichloroethylene; Endocrine Disruptors; Femal | 2011 |
The effect of maternal iodine status on infant outcomes in an iodine-deficient Indian population.
Topics: Adult; Biomarkers; Body Height; Body Weight; Child Development; Diet; Female; Gestational Age; Human | 2011 |
Mid-gestational maternal free thyroxine concentration and offspring neurocognitive development at age two years.
Topics: Adult; Age Factors; Brain; Case-Control Studies; Child; Child Development; Child of Impaired Parents | 2012 |
Maternal thyroid autoimmunity during pregnancy and the risk of attention deficit/hyperactivity problems in children: the Generation R Study.
Topics: Adult; Attention Deficit and Disruptive Behavior Disorders; Autoantibodies; Autoimmunity; Child, Pre | 2012 |
Neurodevelopment in children born to hypothyroid mothers restored to normal thyroxine (T₄) concentration by late pregnancy in Japan: no apparent influence of maternal T₄ deficiency.
Topics: Adolescent; Child; Child Development; Child, Preschool; Developmental Disabilities; Female; Fetal De | 2012 |
Mild maternal thyroid dysfunction at delivery of infants born ≤34 weeks and neurodevelopmental outcome at 5.5 years.
Topics: Adult; Autoantibodies; Brain; Child Development; Child, Preschool; Cognition; Female; Follow-Up Stud | 2012 |
Neonatal hormone changes and growth in lambs born to dams receiving differing nutritional intakes and selenium supplementation during gestation.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Birth Weight; Body Weight; Di | 2012 |
Reversible aberration of neurogenesis affecting late-stage differentiation in the hippocampal dentate gyrus of rat offspring after maternal exposure to manganese chloride.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Proliferation; Cerebellum; Chlorides; Dentate Gyrus; Doub | 2012 |
Thyroid hormone metabolism and environmental chemical exposure.
Topics: Adolescent; Cohort Studies; Environmental Exposure; Environmental Pollutants; Female; Flame Retardan | 2012 |
Prenatal polychlorinated biphenyl exposure is associated with decreased gestational length but not birth weight: archived samples from the Child Health and Development Studies pregnancy cohort.
Topics: Adolescent; Adult; Birth Weight; California; Child; Child, Preschool; Cohort Studies; Environmental | 2012 |
Environmental perchlorate and thiocyanate exposures and infant serum thyroid function.
Topics: Adult; Boston; Breast Feeding; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Infa | 2012 |
Exposure to dexamethasone during late gestation causes female-specific decreases in core body temperature and prepro-thyrotropin-releasing hormone expression in the paraventricular nucleus of the hypothalamus in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents; Body Tempera | 2012 |
Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring.
Topics: Age Factors; Animals; Animals, Newborn; Anti-Infective Agents, Local; Brain-Derived Neurotrophic Fac | 2012 |
The impact of high iodine intake on thyroid function in ewes and lambs.
Topics: Animals; Animals, Newborn; Female; Hypothyroidism; Iodine; Lactation; Pregnancy; Prenatal Exposure D | 2012 |
Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment.
Topics: Animals; Cardiomegaly; Endocrine System; Female; Flame Retardants; Male; Maternal Exposure; Obesity; | 2013 |
Protein kinase Cα is involved in impaired perinatal hypothyroid rat brain development.
Topics: Animals; Animals, Newborn; Antithyroid Agents; Body Weight; Brain; Enzyme Inhibitors; Female; Gene E | 2013 |
Thyroxine levels during pregnancy in healthy women and early child neurodevelopment.
Topics: Adolescent; Adult; Biomarkers; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Delayed onset congenital hypothyroidism in a patient with DUOX2 mutations and maternal iodine excess.
Topics: Alleles; Child; Congenital Hypothyroidism; Dietary Supplements; Dual Oxidases; Female; Humans; Infan | 2013 |
Effects of dysthyroidism in plus maze and social interaction tests.
Topics: Animals; Anxiety; Female; Interpersonal Relations; Male; Maze Learning; Methimazole; Pregnancy; Pren | 2002 |
Effect of low dose mono-ortho 2,3',4,4',5 pentachlorobiphenyl on thyroid hormone status and EROD activity in rat offspring: consequences for risk assessment.
Topics: Adipose Tissue; Animals; Animals, Newborn; Cytochrome P-450 CYP1A1; Female; Liver; Male; Microsomes, | 2003 |
Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation.
Topics: Administration, Oral; Alkanesulfonic Acids; Animals; Animals, Newborn; Body Weight; Choline O-Acetyl | 2003 |
[Screening pregnant women for hypothyroidism: as yet only in high risk groups].
Topics: Adult; Brain; Cost-Benefit Analysis; Diabetes Mellitus, Type 1; Female; Humans; Hypothyroidism; Infa | 2003 |
Early developmental neurotoxicity of a PCB/organochlorine mixture in rodents after gestational and lactational exposure.
Topics: Administration, Oral; Animals; Body Weight; Chlorodiphenyl (54% Chlorine); Dose-Response Relationshi | 2004 |
Effects of maternal exposure to diethylstilbestrol on the development of the reproductive system and thyroid function in male and female rat offspring.
Topics: Animals; Body Weight; Diethylstilbestrol; Female; Follicle Stimulating Hormone; Luteinizing Hormone; | 2003 |
Prenatal programming of adult thyroid function by alcohol and thyroid hormones.
Topics: Adaptation, Physiological; Age Factors; Analysis of Variance; Animals; Corticosterone; Ethanol; Fema | 2004 |
Intrauterine exposure to maternal enterovirus infection as a risk factor for development of autoimmune thyroiditis during childhood and adolescence.
Topics: Adolescent; Adult; Child; Enterovirus Infections; Female; Humans; Male; Pregnancy; Pregnancy Complic | 2004 |
Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain.
Topics: Air Pollutants, Occupational; Animals; Benzhydryl Compounds; Body Weight; Brain; Calmodulin-Binding | 2005 |
In utero and lactational exposure of Long-Evans rats to ammonium perchlorate (AP) disrupts ovarian follicle maturation.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Co | 2004 |
Are maternal thyroid autoantibodies generated by PCBs the missing link to impaired development of the brain?
Topics: Adult; Antibody Formation; Autoantibodies; Brain; Cognition Disorders; Environmental Pollutants; Fem | 2004 |
Effect of prenatal or perinatal nicotine exposure on neonatal thyroid status and offspring growth in rats.
Topics: Administration, Oral; Age Factors; Animals; Animals, Newborn; Body Weight; Female; Injections, Subcu | 2005 |
Effects of hypothyroidism induced by perinatal exposure to PTU on rat behavior and synaptic gene expression.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Antithyroid Agents; Behavior, Animal; Cerebral Cort | 2005 |
Effect of chlorpyrifos-methyl on steroid and thyroid hormones in rat F0- and F1-generations.
Topics: Adrenal Glands; Androgen Antagonists; Animals; Chlorpyrifos; Estradiol; Female; Hypothyroidism; Inse | 2006 |
[Local blood flow in the dorsal hippocampus and cerebellar cortex in progeny of iodine-deficient rats].
Topics: Animals; Animals, Newborn; Cerebellar Cortex; Cerebrovascular Circulation; Cerebrovascular Disorders | 2006 |
Gestational hypothyroxinemia and cognitive function in offspring.
Topics: Child Development; Cognition; Cognition Disorders; Female; Humans; Hypothyroidism; Infant; Infant, N | 2006 |
[Effects of iodine excess and selenium supplement on the levels of thyroid hormone and its receptor expression in filial cerebrum of mice].
Topics: Animals; Animals, Newborn; Cerebrum; Female; Iodine; Male; Mice; Mice, Inbred BALB C; Pregnancy; Pre | 2007 |
Developmental exposure to decabromodiphenyl ether (PBDE 209): effects on thyroid hormone and hepatic enzyme activity in male mouse offspring.
Topics: Animals; Body Weight; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Female; Glucuronosy | 2008 |
Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levels.
Topics: Adipose Tissue; Animals; Body Burden; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Dow | 2007 |
Environmental lead exposure, maternal thyroid function, and childhood growth.
Topics: Adult; Anthropometry; Child; Child, Preschool; Environmental Monitoring; Environmental Pollutants; E | 2008 |
Hypoechoic thyroid nodules on ultrasound 4 years after prenatal exposure to radioiodine: resolution with thyroxine therapy.
Topics: Adult; Female; Humans; Hyperthyroidism; Hypothyroidism; Iodine Radioisotopes; Male; Pregnancy; Pregn | 2008 |
Immunoreactive somatostatin and beta-endorphin content in the brain of mature rats after neonatal exposure to propylthiouracil.
Topics: Animals; beta-Endorphin; Body Weight; Brain Chemistry; Endorphins; Female; Male; Pregnancy; Prenatal | 1982 |
Functional alterations in the hypothalamic-pituitary-thyroid axis in rats exposed prenatally to diazepam.
Topics: Animals; Body Weight; Diazepam; Female; Hypothalamo-Hypophyseal System; Male; Pregnancy; Prenatal Ex | 1983 |
Iodine-induced alterations of thyroid function in newborn infants after prenatal and perinatal exposure to povidone iodine.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Iodides; Povidone; Povidone-Iodine; Preg | 1983 |
Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats.
Topics: Acoustic Stimulation; Animals; Antithyroid Agents; Aroclors; Audiometry; Chlorodiphenyl (54% Chlorin | 1995 |
Perinatal alterations of thyroid hormones and behaviour in adult rats.
Topics: Aging; Animals; Animals, Newborn; Arousal; Avoidance Learning; Behavior, Animal; Exploratory Behavio | 1995 |
Effects of maternal ingestion of Aroclor 1254 (PCB) on the developmental pattern of oxygen consumption and body temperature in neonatal rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aroclors; Blood Gas Analysis; Body Temperature; Car | 1995 |
H and B human blood-group antigen expression in cochlear hair cells is modulated by thyroxine.
Topics: ABO Blood-Group System; Age Factors; Animals; Antibodies, Monoclonal; Cell Differentiation; Cochlea; | 1994 |
Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats.
Topics: Administration, Oral; Animals; Animals, Newborn; Brain; Cytochrome P-450 CYP1A1; Cytochrome P-450 En | 1993 |
[The regulation of the nuclear RNA polymerase activity of the liver and brain in rats of different ages by a cytoplasmic modulator of thyroxine action].
Topics: Aging; Animals; Brain; Cell Nucleus; Cytoplasm; DNA-Directed RNA Polymerases; Embryo, Mammalian; Fem | 1993 |
Pregnancy after high therapeutic doses of iodine-131 in differentiated thyroid cancer: potential risks and recommendations.
Topics: Adenocarcinoma; Adult; Carcinoma, Papillary; Female; Humans; Iodine Radioisotopes; Ovary; Pregnancy; | 1993 |
Predictors of neonatal encephalopathy in full term infants. More information needed about possible role of thyroxine.
Topics: Brain Diseases; Female; Humans; Infant, Newborn; Maternal Exposure; Pregnancy; Prenatal Exposure Del | 1996 |
Effects of prenatal androgenization and postnatal steroid treatment on growth hormone, insulin-like growth factor I and II, insulin, thyroxine, and triidothyronine concentrations in beef heifers.
Topics: Animals; Birth Weight; Cattle; Drug Implants; Estrogens; Female; Growth Hormone; Hormones; Insulin; | 1996 |
Prenatal treatment of fetal hypothyroidism: is there more than one option?
Topics: Adult; Amniotic Fluid; Female; Fetal Blood; Gestational Age; Humans; Hyperthyroidism; Hypothyroidism | 1996 |
Neurobehavioral development of neonatal rats after in-utero hypothyroxinemia: efficacy of prenatal thyroxine treatment.
Topics: Administration, Oral; Animals; Animals, Newborn; Antithyroid Agents; Behavior, Animal; Body Weight; | 1996 |
Modulation by thyroid hormones of the development of external plexiform layer in the rat olfactory bulb.
Topics: Animals; Dendrites; Female; Hyperthyroidism; Hypothyroidism; Neuroglia; Olfactory Bulb; Pregnancy; P | 1996 |
Effects of maternal exposure to chlorinated diphenyl ethers on thyroid hormone concentrations in maternal and juvenile rats.
Topics: Analysis of Variance; Animals; Animals, Suckling; Body Weight; Dose-Response Relationship, Drug; Eth | 1997 |
The mechanisms of transient hypothyroxinemia in infants born to mothers with Graves' disease.
Topics: Bone Development; Female; Follow-Up Studies; Graves Disease; Humans; Hypothyroidism; Infant, Newborn | 1997 |
Prenatal glucocorticoid and T4 effects on lung morphology in preterm lambs.
Topics: Animals; Betamethasone; Female; Gestational Age; Glucocorticoids; Lung; Morphogenesis; Pregnancy; Pr | 1997 |
Impaired cellular immune response in rats exposed perinatally to Baltic Sea herring oil or 2,3,7,8-TCDD.
Topics: Animals; Baltic States; Cytomegalovirus Infections; Female; Fish Oils; Fishes; Hypersensitivity, Del | 1997 |
Thyroid hormones in the pathogenesis of lung hypoplasia and immaturity induced in fetal rats by prenatal exposure to nitrofen.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Disease Models, Animal; Female; Herni | 1997 |
Effects of prenatal maternal TRH stimulation on the postnatal ability of neonatal piglets to cope with a cold challenge.
Topics: Adaptation, Physiological; Age Factors; Animals; Animals, Newborn; Cold Temperature; Female; Pregnan | 1998 |
Neonatal transient hypothyroidism: aetiological study. Italian Collaborative Study on Transient Hypothyroidism.
Topics: Adult; Anti-Infective Agents, Local; Antibodies; Contrast Media; Female; Humans; Hypothyroidism; Inf | 1998 |
Thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to Aroclor 1254 in rats.
Topics: Animals; Body Weight; Chlorodiphenyl (54% Chlorine); Female; Hearing Disorders; Hypothyroidism; Male | 1998 |
Effect of PTU treatment on histone acetylation pattern in the developing rat brain.
Topics: Acetylation; Aging; Animals; Animals, Newborn; Brain; Female; Histones; Pregnancy; Prenatal Exposure | 1999 |
Lung morphometry and collagen and elastin content: changes during normal development and after prenatal hormone exposure in sheep.
Topics: Aging; Animals; Betamethasone; Collagen; Elastin; Female; Gestational Age; Lung; Pregnancy; Prenatal | 1999 |
Maternal hypothyroxinemia disrupts neurotransmitter metabolic enzymes in developing brain.
Topics: Aging; Animals; Brain; Choline O-Acetyltransferase; Disease Models, Animal; Dopa Decarboxylase; Fema | 1999 |
Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy.
Topics: Antibodies; Female; Humans; Infant; Iodide Peroxidase; Pregnancy; Pregnancy Trimester, First; Pregna | 1999 |
Regulation of metallothionein-3 mRNA by thyroid hormone in developing rat brain and primary cultures of rat astrocytes and neurons.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Female; Gene Expression Regulation, Developm | 1999 |
2'3'Cyclic nucleotide 3'phosphodiesterase immunohistochemistry shows an impairment on myelin compaction in hypothyroid rats.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Antithyroid Agents; Brain; Congenital Hypothyro | 2000 |
Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption.
Topics: Animals; Body Weight; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Female; Glucuronosyltransfer | 2002 |
Influences of early thyroid hormone manipulations: delays in pup motor and exploratory behavior are evident in adult operant performance.
Topics: Analysis of Variance; Animals; Antithyroid Agents; Body Mass Index; Conditioning, Operant; Dose-Resp | 2002 |
[The effect of stress on the enzyme systems of the enterocyte microvilli in rat pups and the possible mechanism of the transmission of stress effects from dam to progeny].
Topics: Animals; Animals, Newborn; beta-Galactosidase; Female; Hydrocortisone; Intestine, Small; Lactase; Mi | 1992 |
Elimination kinetics of maternally derived thyrotropin receptor-blocking antibodies in a newborn with significant thyrotropin elevation.
Topics: Autoantibodies; Female; Humans; Hypothyroidism; Immunoglobulin G; Immunoglobulins, Thyroid-Stimulati | 1992 |
Antithyroid drug treatment of Graves' disease in pregnancy: long-term effects on somatic growth, intellectual development and thyroid function of the offspring.
Topics: Birth Weight; Carbimazole; Child; Drug Therapy, Combination; Female; Follow-Up Studies; Graves Disea | 1990 |
Effect of prenatal testosterone treatment on nitrogen utilization and endocrine status of ewe lambs.
Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Fatty Acids, Nonesterified; Female; Genitalia, Female; | 1990 |
Influence of hormonal disturbances on transplacental and multigeneration carcinogenesis in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Estrus; Female; Male; Methylnitrosourea; Methylthiouracil | 1989 |
Effect of maternal hypothyroxinaemia during fetal life on the calmodulin-regulated phosphatase activity in the brain of the adult progeny in the rat.
Topics: Animals; Brain; Calcineurin; Calmodulin; Calmodulin-Binding Proteins; Female; Organ Size; Phosphopro | 1989 |
Effects of altered thyroid states and undernutrition on the calbindin-D28K (calcium-binding protein) content of the hippocampal formation in the developing rat.
Topics: Animals; Calbindin 1; Calbindins; Female; Hippocampus; Nutrition Disorders; Pregnancy; Prenatal Expo | 1989 |
Effect of chronic ingestion of iodide during pregnancy and lactation on rat pup brain enzymes.
Topics: Animals; Brain; Female; Glutamate Dehydrogenase; Growth; Malate Dehydrogenase; Phosphofructokinase-1 | 1986 |
In utero thyroxine therapy for the induction of fetal lung maturity: long term effects.
Topics: Amnion; Anthropometry; Child; Child, Preschool; Female; Fetal Organ Maturity; Humans; Injections; Lu | 1988 |
Effects of anticonvulsant monotherapy in pregnancy on the newborn endocrine system. Preliminary data.
Topics: Anticonvulsants; Endocrine System Diseases; Female; Follicle Stimulating Hormone; Humans; Infant, Ne | 1985 |
Antecedents of cerebral palsy. I. Univariate analysis of risks.
Topics: Anti-Bacterial Agents; Birth Weight; Cerebral Palsy; Delivery, Obstetric; Estrogens; Female; Humans; | 1985 |
Prenatal exposure of the fetal rat to excessive L-thyroxine or 3,5-dimethyl-3'-isopropyl-thyronine produces persistent changes in the thyroid control system.
Topics: Animals; Body Weight; Female; Fetus; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbre | 1985 |