thyroxine has been researched along with Decreased Muscle Tone in 20 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypothyroidism was found in 21." | 2.77 | Euthyroid submedian free T4 and subclinical hypothyroidism may have a detrimental clinical effect in Down syndrome. ( Abulibdeh, A; Kastiel, Y; Lebel, E; Malkiel, S; Tenenbaum, A; Zangen, DH, 2012) |
| "Tachycardia was abated (84 beats/min), weight gain was 3 kg in 1 yr, and SHBG was 102 nmol/liter." | 1.35 | Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8. ( d'Herbomez, M; Gottrand, F; Jansen, J; Ladsous, M; Pigeyre, M; Proust-Lemoine, E; Visser, TJ; Wémeau, JL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 16 (80.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Angelis, M | 1 |
| Maity-Kumar, G | 1 |
| Schriever, SC | 1 |
| Kozlova, EV | 1 |
| Müller, TD | 1 |
| Pfluger, PT | 1 |
| Curras-Collazo, MC | 1 |
| Schramm, KW | 1 |
| Groeneweg, S | 1 |
| Kersseboom, S | 2 |
| van den Berge, A | 1 |
| Dolcetta-Capuzzo, A | 1 |
| van Geest, FS | 1 |
| van Heerebeek, REA | 1 |
| Arjona, FJ | 1 |
| Meima, ME | 1 |
| Peeters, RP | 2 |
| Visser, WE | 2 |
| Visser, TJ | 4 |
| Salveridou, E | 1 |
| Mayerl, S | 2 |
| Sundaram, SM | 1 |
| Markova, B | 1 |
| Heuer, H | 2 |
| Islam, MS | 1 |
| Namba, N | 1 |
| Ohata, Y | 1 |
| Fujiwara, M | 1 |
| Nakano, C | 1 |
| Takeyari, S | 1 |
| Miyata, K | 1 |
| Nakano, Y | 1 |
| Yamamoto, K | 1 |
| Nakayama, H | 1 |
| Kitaoka, T | 1 |
| Kubota, T | 1 |
| Ozono, K | 1 |
| Kremers, GJ | 1 |
| Friesema, EC | 1 |
| Klootwijk, W | 1 |
| López-Marín, L | 1 |
| Martín-Belinchón, M | 1 |
| Gutiérrez-Solana, LG | 1 |
| Morte-Molina, B | 1 |
| Duat-Rodríguez, A | 1 |
| Bernal, J | 3 |
| Fu, J | 1 |
| Dumitrescu, AM | 1 |
| Müller, J | 1 |
| Bauer, R | 1 |
| Richert, S | 1 |
| Kassmann, CM | 1 |
| Darras, VM | 1 |
| Buder, K | 1 |
| Boelen, A | 1 |
| Rodrigues, F | 1 |
| Grenha, J | 1 |
| Ortez, C | 1 |
| Nascimento, A | 1 |
| Morte, B | 2 |
| M-Belinchón, M | 1 |
| Armstrong, J | 1 |
| Colomer, J | 1 |
| García-de Teresa, B | 1 |
| González-Del Angel, A | 1 |
| Reyna-Fabián, ME | 1 |
| Ruiz-Reyes, Mde L | 1 |
| Calzada-León, R | 1 |
| Pérez-Enríquez, B | 1 |
| Alcántara-Ortigoza, MA | 1 |
| Kim, JH | 1 |
| Kim, YM | 1 |
| Yum, MS | 1 |
| Choi, JH | 1 |
| Lee, BH | 1 |
| Kim, GH | 1 |
| Yoo, HW | 1 |
| Guadaño-Ferraz, A | 1 |
| Krude, H | 1 |
| Kühnen, P | 1 |
| Biebermann, H | 2 |
| Braun, D | 1 |
| Schweizer, U | 2 |
| López Úbeda, M | 1 |
| de Arriba Muñoz, A | 1 |
| Abenia Usón, P | 1 |
| Labarta Aizpún, JI | 1 |
| Filho, HC | 1 |
| Marui, S | 1 |
| Manna, TD | 1 |
| Brust, ES | 1 |
| Radonsky, V | 1 |
| Kuperman, H | 1 |
| Dichtchekenian, V | 1 |
| Setian, N | 1 |
| Damiani, D | 1 |
| Tenenbaum, A | 1 |
| Lebel, E | 1 |
| Malkiel, S | 1 |
| Kastiel, Y | 1 |
| Abulibdeh, A | 1 |
| Zangen, DH | 1 |
| Ambrugger, P | 1 |
| Tarnow, P | 1 |
| von Moers, A | 1 |
| Grueters, A | 1 |
| Wémeau, JL | 1 |
| Pigeyre, M | 1 |
| Proust-Lemoine, E | 1 |
| d'Herbomez, M | 1 |
| Gottrand, F | 1 |
| Jansen, J | 1 |
| Ladsous, M | 1 |
6 reviews available for thyroxine and Decreased Muscle Tone
| Article | Year |
|---|---|
Tissue-Specific Function of Thyroid Hormone Transporters: New Insights from Mouse Models.
Topics: Animals; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; Muscle Hypotonia; M | 2020 |
[MCT8-specific thyroid hormone cell transporter deficiency: a case report and review of the literature].
Topics: Amino Acid Substitution; Anticonvulsants; Biological Transport; Brain; Child, Preschool; Cord Blood | 2013 |
Inherited defects in thyroid hormone cell-membrane transport and metabolism.
Topics: Cell Membrane; Humans; Male; Membrane Transport Proteins; Mental Retardation, X-Linked; Monocarboxyl | 2014 |
Thyroid hormone transporters--functions and clinical implications.
Topics: Animals; Blood-Brain Barrier; Brain; Choroid Plexus; Humans; Membrane Transport Proteins; Mental Ret | 2015 |
Treatment of congenital thyroid dysfunction: Achievements and challenges.
Topics: Congenital Hypothyroidism; Hormone Replacement Therapy; Humans; Hydrolases; Infant, Newborn; Iodide | 2015 |
Thyroid hormone transport in developing brain.
Topics: Animals; Biological Transport; Brain; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Tran | 2011 |
1 trial available for thyroxine and Decreased Muscle Tone
| Article | Year |
|---|---|
Euthyroid submedian free T4 and subclinical hypothyroidism may have a detrimental clinical effect in Down syndrome.
Topics: Adolescent; Child; Child, Preschool; Down Syndrome; Female; Hormone Replacement Therapy; Humans; Hyp | 2012 |
13 other studies available for thyroxine and Decreased Muscle Tone
| Article | Year |
|---|---|
Development and validation of an LC-MS/MS methodology for the quantification of thyroid hormones in dko MCT8/OATP1C1 mouse brain.
Topics: Animals; Brain; Chromatography, Liquid; Isotopes; Mental Retardation, X-Linked; Mice; Monocarboxylic | 2022 |
Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Diiodothyronines; Disease Models, Animal | 2019 |
Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients.
Topics: Adolescent; Asian People; Cell Line, Tumor; Cell Membrane; Child; Child, Preschool; Cytoplasm; Genet | 2019 |
Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution.
Topics: Animals; Blotting, Western; Cell Extracts; Cell Line; Cell Survival; Fluorescence Recovery After Pho | 2013 |
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
Topics: Animals; Cerebral Cortex; GABAergic Neurons; Homeostasis; Membrane Transport Proteins; Mental Retard | 2014 |
Hypotonic male infant and MCT8 deficiency - a diagnosis to think about.
Topics: Child, Preschool; Humans; Male; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; Musc | 2014 |
Deletion of exon 1 of the SLC16A2 gene: a common occurrence in patients with Allan-Herndon-Dudley syndrome.
Topics: Child, Preschool; Computational Biology; Exons; Female; Gene Deletion; Humans; Hypothyroidism; Male; | 2015 |
Clinical and endocrine features of two Allan-Herndon-Dudley syndrome patients with monocarboxylate transporter 8 mutations.
Topics: Brain; Child, Preschool; Humans; Infant; Magnetic Resonance Imaging; Male; Mental Retardation, X-Lin | 2015 |
Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones.
Topics: Animals; Cell Membrane; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Dogs; Genistein; Iodine | 2015 |
Hypopituitarism: An uncommon cause of developmental delay.
Topics: Constipation; Female; Humans; Hypopituitarism; Infant; LIM-Homeodomain Proteins; Male; Muscle Hypoto | 2018 |
Novel mutation in MCT8 gene in a Brazilian boy with thyroid hormone resistance and severe neurologic abnormalities.
Topics: Amino Acid Sequence; Brain Diseases; Child; Humans; Male; Monocarboxylic Acid Transporters; Muscle H | 2011 |
Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8.
Topics: Animals; Child, Preschool; CHO Cells; Cricetinae; Female; Humans; Male; Mental Retardation, X-Linked | 2005 |
Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8.
Topics: Adolescent; Antithyroid Agents; Humans; Intellectual Disability; Male; Monocarboxylic Acid Transport | 2008 |