Page last updated: 2024-11-07

thyroxine and Decreased Muscle Tone

thyroxine has been researched along with Decreased Muscle Tone in 20 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"Hypothyroidism was found in 21."2.77Euthyroid submedian free T4 and subclinical hypothyroidism may have a detrimental clinical effect in Down syndrome. ( Abulibdeh, A; Kastiel, Y; Lebel, E; Malkiel, S; Tenenbaum, A; Zangen, DH, 2012)
"Tachycardia was abated (84 beats/min), weight gain was 3 kg in 1 yr, and SHBG was 102 nmol/liter."1.35Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8. ( d'Herbomez, M; Gottrand, F; Jansen, J; Ladsous, M; Pigeyre, M; Proust-Lemoine, E; Visser, TJ; Wémeau, JL, 2008)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (10.00)29.6817
2010's16 (80.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
De Angelis, M1
Maity-Kumar, G1
Schriever, SC1
Kozlova, EV1
Müller, TD1
Pfluger, PT1
Curras-Collazo, MC1
Schramm, KW1
Groeneweg, S1
Kersseboom, S2
van den Berge, A1
Dolcetta-Capuzzo, A1
van Geest, FS1
van Heerebeek, REA1
Arjona, FJ1
Meima, ME1
Peeters, RP2
Visser, WE2
Visser, TJ4
Salveridou, E1
Mayerl, S2
Sundaram, SM1
Markova, B1
Heuer, H2
Islam, MS1
Namba, N1
Ohata, Y1
Fujiwara, M1
Nakano, C1
Takeyari, S1
Miyata, K1
Nakano, Y1
Yamamoto, K1
Nakayama, H1
Kitaoka, T1
Kubota, T1
Ozono, K1
Kremers, GJ1
Friesema, EC1
Klootwijk, W1
López-Marín, L1
Martín-Belinchón, M1
Gutiérrez-Solana, LG1
Morte-Molina, B1
Duat-Rodríguez, A1
Bernal, J3
Fu, J1
Dumitrescu, AM1
Müller, J1
Bauer, R1
Richert, S1
Kassmann, CM1
Darras, VM1
Buder, K1
Boelen, A1
Rodrigues, F1
Grenha, J1
Ortez, C1
Nascimento, A1
Morte, B2
M-Belinchón, M1
Armstrong, J1
Colomer, J1
García-de Teresa, B1
González-Del Angel, A1
Reyna-Fabián, ME1
Ruiz-Reyes, Mde L1
Calzada-León, R1
Pérez-Enríquez, B1
Alcántara-Ortigoza, MA1
Kim, JH1
Kim, YM1
Yum, MS1
Choi, JH1
Lee, BH1
Kim, GH1
Yoo, HW1
Guadaño-Ferraz, A1
Krude, H1
Kühnen, P1
Biebermann, H2
Braun, D1
Schweizer, U2
López Úbeda, M1
de Arriba Muñoz, A1
Abenia Usón, P1
Labarta Aizpún, JI1
Filho, HC1
Marui, S1
Manna, TD1
Brust, ES1
Radonsky, V1
Kuperman, H1
Dichtchekenian, V1
Setian, N1
Damiani, D1
Tenenbaum, A1
Lebel, E1
Malkiel, S1
Kastiel, Y1
Abulibdeh, A1
Zangen, DH1
Ambrugger, P1
Tarnow, P1
von Moers, A1
Grueters, A1
Wémeau, JL1
Pigeyre, M1
Proust-Lemoine, E1
d'Herbomez, M1
Gottrand, F1
Jansen, J1
Ladsous, M1

Reviews

6 reviews available for thyroxine and Decreased Muscle Tone

ArticleYear
Tissue-Specific Function of Thyroid Hormone Transporters: New Insights from Mouse Models.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2020, Volume: 128, Issue:6-07

    Topics: Animals; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; Muscle Hypotonia; M

2020
[MCT8-specific thyroid hormone cell transporter deficiency: a case report and review of the literature].
    Revista de neurologia, 2013, Jun-16, Volume: 56, Issue:12

    Topics: Amino Acid Substitution; Anticonvulsants; Biological Transport; Brain; Child, Preschool; Cord Blood

2013
Inherited defects in thyroid hormone cell-membrane transport and metabolism.
    Best practice & research. Clinical endocrinology & metabolism, 2014, Volume: 28, Issue:2

    Topics: Cell Membrane; Humans; Male; Membrane Transport Proteins; Mental Retardation, X-Linked; Monocarboxyl

2014
Thyroid hormone transporters--functions and clinical implications.
    Nature reviews. Endocrinology, 2015, Volume: 11, Issue:7

    Topics: Animals; Blood-Brain Barrier; Brain; Choroid Plexus; Humans; Membrane Transport Proteins; Mental Ret

2015
Treatment of congenital thyroid dysfunction: Achievements and challenges.
    Best practice & research. Clinical endocrinology & metabolism, 2015, Volume: 29, Issue:3

    Topics: Congenital Hypothyroidism; Hormone Replacement Therapy; Humans; Hydrolases; Infant, Newborn; Iodide

2015
Thyroid hormone transport in developing brain.
    Current opinion in endocrinology, diabetes, and obesity, 2011, Volume: 18, Issue:5

    Topics: Animals; Biological Transport; Brain; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Tran

2011

Trials

1 trial available for thyroxine and Decreased Muscle Tone

ArticleYear
Euthyroid submedian free T4 and subclinical hypothyroidism may have a detrimental clinical effect in Down syndrome.
    Hormone research in paediatrics, 2012, Volume: 78, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Down Syndrome; Female; Hormone Replacement Therapy; Humans; Hyp

2012

Other Studies

13 other studies available for thyroxine and Decreased Muscle Tone

ArticleYear
Development and validation of an LC-MS/MS methodology for the quantification of thyroid hormones in dko MCT8/OATP1C1 mouse brain.
    Journal of pharmaceutical and biomedical analysis, 2022, Nov-30, Volume: 221

    Topics: Animals; Brain; Chromatography, Liquid; Isotopes; Mental Retardation, X-Linked; Mice; Monocarboxylic

2022
    Thyroid : official journal of the American Thyroid Association, 2019, Volume: 29, Issue:10

    Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Diiodothyronines; Disease Models, Animal

2019
Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients.
    Endocrine journal, 2019, Jan-28, Volume: 66, Issue:1

    Topics: Adolescent; Asian People; Cell Line, Tumor; Cell Membrane; Child; Child, Preschool; Cytoplasm; Genet

2019
Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution.
    Molecular endocrinology (Baltimore, Md.), 2013, Volume: 27, Issue:5

    Topics: Animals; Blotting, Western; Cell Extracts; Cell Line; Cell Survival; Fluorescence Recovery After Pho

2013
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
    The Journal of clinical investigation, 2014, Volume: 124, Issue:5

    Topics: Animals; Cerebral Cortex; GABAergic Neurons; Homeostasis; Membrane Transport Proteins; Mental Retard

2014
Hypotonic male infant and MCT8 deficiency - a diagnosis to think about.
    BMC pediatrics, 2014, Oct-04, Volume: 14

    Topics: Child, Preschool; Humans; Male; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; Musc

2014
Deletion of exon 1 of the SLC16A2 gene: a common occurrence in patients with Allan-Herndon-Dudley syndrome.
    Thyroid : official journal of the American Thyroid Association, 2015, Volume: 25, Issue:3

    Topics: Child, Preschool; Computational Biology; Exons; Female; Gene Deletion; Humans; Hypothyroidism; Male;

2015
Clinical and endocrine features of two Allan-Herndon-Dudley syndrome patients with monocarboxylate transporter 8 mutations.
    Hormone research in paediatrics, 2015, Volume: 83, Issue:4

    Topics: Brain; Child, Preschool; Humans; Infant; Magnetic Resonance Imaging; Male; Mental Retardation, X-Lin

2015
Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones.
    Endocrinology, 2015, Volume: 156, Issue:12

    Topics: Animals; Cell Membrane; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Dogs; Genistein; Iodine

2015
Hypopituitarism: An uncommon cause of developmental delay.
    Neurologia, 2018, Volume: 33, Issue:8

    Topics: Constipation; Female; Humans; Hypopituitarism; Infant; LIM-Homeodomain Proteins; Male; Muscle Hypoto

2018
Novel mutation in MCT8 gene in a Brazilian boy with thyroid hormone resistance and severe neurologic abnormalities.
    Arquivos brasileiros de endocrinologia e metabologia, 2011, Volume: 55, Issue:1

    Topics: Amino Acid Sequence; Brain Diseases; Child; Humans; Male; Monocarboxylic Acid Transporters; Muscle H

2011
Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8.
    European journal of endocrinology, 2005, Volume: 153, Issue:3

    Topics: Animals; Child, Preschool; CHO Cells; Cricetinae; Female; Humans; Male; Mental Retardation, X-Linked

2005
Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:6

    Topics: Adolescent; Antithyroid Agents; Humans; Intellectual Disability; Male; Monocarboxylic Acid Transport

2008