Page last updated: 2024-11-06

thyroxine and Cystinosis

thyroxine has been researched along with Cystinosis in 5 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Cystinosis: A metabolic disease characterized by the defective transport of CYSTINE across the lysosomal membrane due to mutation of a membrane protein cystinosin. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. In the KIDNEY, nephropathic cystinosis is a common cause of RENAL FANCONI SYNDROME.

Research Excerpts

ExcerptRelevanceReference
"Eleven children with nephropathic cystinosis without clinical features of hyperthyroidism or hypothyroidism had elevated serum levels of immunoreactive TSH."1.26Pituitary resistance to thyroid hormone in cystinosis. ( Bercu, BB; Orloff, S; Schulman, JD, 1980)
"Children with nephropathic cystinosis exhibit marked growth retardation."1.26Endocrine studies in cystinosis: compensated primary hypothyroidism. ( Howley, PM; Lucky, AW; Megyesi, K; Schulman, JD; Spielberg, SP, 1977)
"Hypothyroidism is a common finding in cystinosis, and it is suggested that thyroxine treatment be started when the TSH concentration becomes raised."1.26Hypothyroidism in children with cystinosis. ( Burke, JR; Chantler, C; El-Bishti, MM; Maisey, MN, 1978)
"Compensated hypothyroidism is frequent in cystinosis and may be one factor in the severe growth retardation in this condition."1.26[Thyroid involvement in cystinosis]. ( Broyer, M; Czernichow, P; Lenoir, G; Rappaport, R; Roy, MP, 1978)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bercu, BB1
Orloff, S1
Schulman, JD2
Kimonis, VE1
Troendle, J1
Rose, SR1
Yang, ML1
Markello, TC1
Gahl, WA1
Lucky, AW1
Howley, PM1
Megyesi, K1
Spielberg, SP1
Burke, JR1
El-Bishti, MM1
Maisey, MN1
Chantler, C1
Czernichow, P1
Lenoir, G1
Roy, MP1
Rappaport, R1
Broyer, M1

Trials

1 trial available for thyroxine and Cystinosis

ArticleYear
Effects of early cysteamine therapy on thyroid function and growth in nephropathic cystinosis.
    The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:11

    Topics: Adolescent; Adult; Age Determination by Skeleton; Child; Child, Preschool; Cysteamine; Cystinosis; H

1995

Other Studies

4 other studies available for thyroxine and Cystinosis

ArticleYear
Pituitary resistance to thyroid hormone in cystinosis.
    The Journal of clinical endocrinology and metabolism, 1980, Volume: 51, Issue:6

    Topics: Child; Child, Preschool; Cystinosis; Drug Resistance; Feedback; Female; Humans; Male; Pituitary Glan

1980
Endocrine studies in cystinosis: compensated primary hypothyroidism.
    The Journal of pediatrics, 1977, Volume: 91, Issue:2

    Topics: Child; Child, Preschool; Creatinine; Cystinosis; Female; Follicle Stimulating Hormone; Growth Hormon

1977
Hypothyroidism in children with cystinosis.
    Archives of disease in childhood, 1978, Volume: 53, Issue:12

    Topics: Adolescent; Child; Child, Preschool; Cystinosis; Humans; Hypothyroidism; Kidney Failure, Chronic; Th

1978
[Thyroid involvement in cystinosis].
    Archives francaises de pediatrie, 1978, Volume: 35, Issue:9

    Topics: Adolescent; Child; Child, Preschool; Cholesterol; Cystinosis; Female; Follow-Up Studies; Growth Diso

1978