thyroxine has been researched along with Cystinosis in 5 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Cystinosis: A metabolic disease characterized by the defective transport of CYSTINE across the lysosomal membrane due to mutation of a membrane protein cystinosin. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. In the KIDNEY, nephropathic cystinosis is a common cause of RENAL FANCONI SYNDROME.
Excerpt | Relevance | Reference |
---|---|---|
"Eleven children with nephropathic cystinosis without clinical features of hyperthyroidism or hypothyroidism had elevated serum levels of immunoreactive TSH." | 1.26 | Pituitary resistance to thyroid hormone in cystinosis. ( Bercu, BB; Orloff, S; Schulman, JD, 1980) |
"Children with nephropathic cystinosis exhibit marked growth retardation." | 1.26 | Endocrine studies in cystinosis: compensated primary hypothyroidism. ( Howley, PM; Lucky, AW; Megyesi, K; Schulman, JD; Spielberg, SP, 1977) |
"Hypothyroidism is a common finding in cystinosis, and it is suggested that thyroxine treatment be started when the TSH concentration becomes raised." | 1.26 | Hypothyroidism in children with cystinosis. ( Burke, JR; Chantler, C; El-Bishti, MM; Maisey, MN, 1978) |
"Compensated hypothyroidism is frequent in cystinosis and may be one factor in the severe growth retardation in this condition." | 1.26 | [Thyroid involvement in cystinosis]. ( Broyer, M; Czernichow, P; Lenoir, G; Rappaport, R; Roy, MP, 1978) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (80.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Bercu, BB | 1 |
Orloff, S | 1 |
Schulman, JD | 2 |
Kimonis, VE | 1 |
Troendle, J | 1 |
Rose, SR | 1 |
Yang, ML | 1 |
Markello, TC | 1 |
Gahl, WA | 1 |
Lucky, AW | 1 |
Howley, PM | 1 |
Megyesi, K | 1 |
Spielberg, SP | 1 |
Burke, JR | 1 |
El-Bishti, MM | 1 |
Maisey, MN | 1 |
Chantler, C | 1 |
Czernichow, P | 1 |
Lenoir, G | 1 |
Roy, MP | 1 |
Rappaport, R | 1 |
Broyer, M | 1 |
1 trial available for thyroxine and Cystinosis
Article | Year |
---|---|
Effects of early cysteamine therapy on thyroid function and growth in nephropathic cystinosis.
Topics: Adolescent; Adult; Age Determination by Skeleton; Child; Child, Preschool; Cysteamine; Cystinosis; H | 1995 |
4 other studies available for thyroxine and Cystinosis
Article | Year |
---|---|
Pituitary resistance to thyroid hormone in cystinosis.
Topics: Child; Child, Preschool; Cystinosis; Drug Resistance; Feedback; Female; Humans; Male; Pituitary Glan | 1980 |
Endocrine studies in cystinosis: compensated primary hypothyroidism.
Topics: Child; Child, Preschool; Creatinine; Cystinosis; Female; Follicle Stimulating Hormone; Growth Hormon | 1977 |
Hypothyroidism in children with cystinosis.
Topics: Adolescent; Child; Child, Preschool; Cystinosis; Humans; Hypothyroidism; Kidney Failure, Chronic; Th | 1978 |
[Thyroid involvement in cystinosis].
Topics: Adolescent; Child; Child, Preschool; Cholesterol; Cystinosis; Female; Follow-Up Studies; Growth Diso | 1978 |