thyroxine has been researched along with Coronary Artery Disease in 30 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study focuses on the levels of prolactin, cortisol, free thyroxine (fT4) and thyroid-stimulating hormone (TSH) as markers of Metabolic Syndrome (MS) which is a risk factor for Coronary Artery Disease (CAD) and type 2 Diabetes Mellitus (DM)." | 7.91 | PROLACTIN, CORTISOL, FREE THYROXINE AND THYROID-STIMULATING HORMONE - MARKERS OF STAGING OF METABOLIC SYNDROME AS A RISK FACTOR OF CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS. ( Chmyr, N; Dutka, R; Leontieva, Z; Svitlyk, H, 2019) |
| "Mendelian randomization analyses for stroke and CAD using genetic instruments associated with normal range thyrotropin (TSH) and free thyroxine levels or Hashimoto's thyroiditis and Graves' disease." | 3.96 | Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study. ( Chaker, L; Del Greco M, F; Deloukas, P; Kus, A; Marouli, E; Medici, M; Peeters, R; Teumer, A, 2020) |
| "The study focuses on the levels of prolactin, cortisol, free thyroxine (fT4) and thyroid-stimulating hormone (TSH) as markers of Metabolic Syndrome (MS) which is a risk factor for Coronary Artery Disease (CAD) and type 2 Diabetes Mellitus (DM)." | 3.91 | PROLACTIN, CORTISOL, FREE THYROXINE AND THYROID-STIMULATING HORMONE - MARKERS OF STAGING OF METABOLIC SYNDROME AS A RISK FACTOR OF CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS. ( Chmyr, N; Dutka, R; Leontieva, Z; Svitlyk, H, 2019) |
| " TSH, free thyroxine, serum lipid levels and high-sensitivity C-reactive protein levels were measured and compared to the severity of coronary artery disease." | 3.74 | Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients. ( Ahn, YK; Jeong, JW; Jeong, MH; Kim, NH; Lee, EM; Lee, J; Oh, SK; Rhee, SJ; Yoo, NJ; Yun, KH, 2007) |
| "In a group of patients with developed primary hypothyroidism the authors investigated in a longitudinal eight-month trial the effect of hormonal substitution therapy with thyroxine (T4) on the serum concentration of lipids, apolipoprotein B and lipoprotein (a)--risk factors for the development of early coronary sclerosis." | 3.70 | [Lipoprotein(a)--a risk factor for coronary sclerosis in patients with hypothyroidism]. ( Dieplinger, H; Oravec, D; Oravec, S, 1998) |
| "Sub-clinical hyperthyroidism is not associated with CHD or mortality from cardiovascular causes." | 2.44 | Impact of subclinical thyroid disorders on coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis. ( Arora, R; Barsano, CP; Duggal, J; Maldonado, F; Molnar, J; Singh, S, 2008) |
| "These findings suggest that elevated cholesterol concentrations in the blood, especially against the background of suppressed thyroid function, can directly induce considerable damage to cardiomyocytes, intramural vessels, and erythrocytes without the development of myocardial ischemia and in the absence of atherosclerotic plaques." | 1.39 | Structural changes in the myocardium and serum lipid spectrum in experimental hypercholesterolemia and hypothyroidism. ( Klinnikova, MG; Lushnikova, EL; Molodykh, OP; Nepomnyashchikh, LM; Nepomnyashchikh, RD; Pichigin, VI; Polyakov, LP; Poteryaeva, ON; Russkikh, GS, 2013) |
| "Whether to treat subclinical hypothyroidism (SH) remains controversial." | 1.35 | Increased serum chitotriosidase activity following restoration of euthyroidism in patients with subclinical hypothyroidism. ( Erdal, M; Gharib, H; Hasimi, A; Kutlu, M; Saglam, K; Sahin, M; Taslipinar, A; Uckaya, G; Yarpuz, MY, 2008) |
| "Overt hypothyroidism has been found to be associated with cardiovascular disease." | 1.32 | Thyroid function is associated with presence and severity of coronary atherosclerosis. ( Auer, J; Berent, R; Eber, B; Lassnig, E; Weber, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Che, W | 1 |
| Shi, K | 1 |
| Huang, Y | 1 |
| Xu, C | 1 |
| Fei, M | 1 |
| Fan, X | 1 |
| Zhang, J | 1 |
| Hu, X | 1 |
| Hu, F | 1 |
| Qin, S | 1 |
| Zhang, X | 1 |
| Huang, Q | 1 |
| Yu, F | 1 |
| Dutka, R | 1 |
| Chmyr, N | 1 |
| Svitlyk, H | 1 |
| Leontieva, Z | 1 |
| Marouli, E | 1 |
| Kus, A | 1 |
| Del Greco M, F | 1 |
| Chaker, L | 1 |
| Peeters, R | 1 |
| Teumer, A | 1 |
| Deloukas, P | 1 |
| Medici, M | 1 |
| Yuan, D | 1 |
| Zhang, C | 1 |
| Jia, S | 1 |
| Liu, Y | 1 |
| Jiang, L | 1 |
| Xu, L | 1 |
| Zhang, Y | 2 |
| Xu, J | 1 |
| Xu, B | 1 |
| Hui, R | 1 |
| Gao, R | 1 |
| Gao, Z | 1 |
| Song, L | 1 |
| Yuan, J | 1 |
| de Miranda, EJFP | 1 |
| Bittencourt, MS | 1 |
| Staniak, HL | 1 |
| Sharovsky, R | 1 |
| Pereira, AC | 1 |
| Foppa, M | 1 |
| Santos, IS | 1 |
| Lotufo, PA | 1 |
| Benseñor, IM | 1 |
| Ortolani, PD | 1 |
| Romaldini, JH | 1 |
| Guerra, RA | 1 |
| Portes, ES | 1 |
| Meireles, GCX | 1 |
| Pimenta, J | 1 |
| Ha, CE | 1 |
| Bhagavan, NV | 1 |
| Nepomnyashchikh, LM | 1 |
| Lushnikova, EL | 1 |
| Polyakov, LP | 1 |
| Molodykh, OP | 1 |
| Klinnikova, MG | 1 |
| Russkikh, GS | 1 |
| Poteryaeva, ON | 1 |
| Nepomnyashchikh, RD | 1 |
| Pichigin, VI | 1 |
| Kim, BK | 1 |
| Chang, Y | 1 |
| Ryu, S | 1 |
| Cho, J | 1 |
| Lee, WY | 2 |
| Rhee, EJ | 2 |
| Kwon, MJ | 1 |
| Rampal, S | 1 |
| Zhao, D | 1 |
| Pastor-Barriuso, R | 1 |
| Lima, JA | 1 |
| Shin, H | 1 |
| Guallar, E | 1 |
| Park, HJ | 1 |
| Kim, J | 1 |
| Han, EJ | 1 |
| Park, SE | 1 |
| Park, CY | 1 |
| Oh, KW | 1 |
| Park, SW | 1 |
| Brozaitiene, J | 2 |
| Mickuviene, N | 1 |
| Podlipskyte, A | 2 |
| Burkauskas, J | 1 |
| Bunevicius, R | 2 |
| Erdal, M | 1 |
| Sahin, M | 1 |
| Saglam, K | 1 |
| Hasimi, A | 1 |
| Uckaya, G | 1 |
| Yarpuz, MY | 1 |
| Taslipinar, A | 1 |
| Gharib, H | 1 |
| Kutlu, M | 1 |
| Coceani, M | 1 |
| Iervasi, G | 1 |
| Pingitore, A | 1 |
| Carpeggiani, C | 1 |
| L'Abbate, A | 1 |
| Mugii, S | 1 |
| Hanada, H | 1 |
| Okubo, M | 1 |
| Masuda, D | 1 |
| Takeoka, K | 1 |
| Hidaka, Y | 1 |
| Ohama, T | 1 |
| Matsuyama, A | 1 |
| Nakagawa-Toyama, Y | 1 |
| Nishida, M | 1 |
| Ishigami, M | 1 |
| Komuro, I | 1 |
| Yamashita, S | 1 |
| Kim, ES | 1 |
| Shin, JA | 1 |
| Shin, JY | 1 |
| Lim, DJ | 1 |
| Moon, SD | 1 |
| Son, HY | 1 |
| Han, JH | 1 |
| Ertaş, F | 1 |
| Kaya, H | 1 |
| Soydinç, MS | 1 |
| Bunevicius, A | 1 |
| Gintauskiene, V | 1 |
| Zaliunas, R | 1 |
| Prange, AJ | 1 |
| OLIVER, MF | 1 |
| BOYD, GS | 1 |
| HERRMANN, GR | 1 |
| SAMAWI, A | 1 |
| WINTERS, WL | 1 |
| SOLOFF, LA | 1 |
| BROSIUS, FC | 1 |
| SINITSINA, TA | 1 |
| SCHAEFFER, WE | 1 |
| CADY, JB | 1 |
| Auer, J | 1 |
| Berent, R | 1 |
| Weber, T | 1 |
| Lassnig, E | 1 |
| Eber, B | 1 |
| Telkova, IL | 2 |
| Tepliakov, AT | 2 |
| Yun, KH | 1 |
| Jeong, MH | 1 |
| Oh, SK | 1 |
| Lee, EM | 1 |
| Lee, J | 1 |
| Rhee, SJ | 1 |
| Yoo, NJ | 1 |
| Kim, NH | 1 |
| Ahn, YK | 1 |
| Jeong, JW | 1 |
| Singh, S | 1 |
| Duggal, J | 1 |
| Molnar, J | 1 |
| Maldonado, F | 1 |
| Barsano, CP | 1 |
| Arora, R | 1 |
| Oravec, S | 1 |
| Oravec, D | 1 |
| Dieplinger, H | 1 |
| Karpov, RS | 1 |
| Syed, AU | 1 |
| El Watidy, AF | 1 |
| Akhlaque, NB | 1 |
| Wahba, A | 1 |
| El Oakley, RM | 1 |
| Imran, K | 1 |
| Al Bukhari, EA | 1 |
| Al Fagih, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Endocrine Changes in Adults Undergoing Cardiac Surgery[NCT03736499] | 500 participants (Anticipated) | Observational | 2018-07-01 | Active, not recruiting | |||
| Effects of Dapagliflozin on Hyperlipidemia, Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients (DAPHNIS Study)[NCT02577159] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-07-01 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thyroxine and Coronary Artery Disease
| Article | Year |
|---|---|
Novel insights into the pleiotropic effects of human serum albumin in health and disease.
Topics: Biological Transport; Coronary Artery Disease; Crystallography, X-Ray; Fatty Acids; Humans; Islets o | 2013 |
Impact of subclinical thyroid disorders on coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis.
Topics: Cardiovascular Diseases; Cause of Death; Coronary Artery Disease; Humans; Hyperthyroidism; Hypothyro | 2008 |
28 other studies available for thyroxine and Coronary Artery Disease
| Article | Year |
|---|---|
FT4/FT3 ratio: A novel biomarker predicts coronary microvascular dysfunction (CMD) in euthyroid INOCA patients.
Topics: Biomarkers; Coronary Artery Disease; Humans; Myocardial Ischemia; Prospective Studies; Thyroxine; Tr | 2022 |
PROLACTIN, CORTISOL, FREE THYROXINE AND THYROID-STIMULATING HORMONE - MARKERS OF STAGING OF METABOLIC SYNDROME AS A RISK FACTOR OF CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS.
Topics: Biomarkers; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Hydrocortisone; Meta | 2019 |
Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study.
Topics: Adult; Atrial Fibrillation; Body Mass Index; Coronary Artery Disease; Datasets as Topic; Female; Gra | 2020 |
Predictive value of free triiodothyronine (FT3) to free thyroxine (FT4) ratio in long-term outcomes of euthyroid patients with three-vessel coronary artery disease.
Topics: Aged; Biomarkers; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Prognosis; Prospective | 2021 |
Thyrotropin and free thyroxine levels and coronary artery disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
Topics: Adult; Aged; Biomarkers; Brazil; Computed Tomography Angiography; Coronary Angiography; Coronary Art | 2018 |
Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study.
Topics: Age Factors; Aged; Cholesterol; Coronary Angiography; Coronary Artery Disease; Coronary Stenosis; Cr | 2018 |
Structural changes in the myocardium and serum lipid spectrum in experimental hypercholesterolemia and hypothyroidism.
Topics: Animals; Atherosclerosis; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; | 2013 |
Thyroid hormones and coronary artery calcification in euthyroid men and women.
Topics: Adult; Aged; Asymptomatic Diseases; Cohort Studies; Comorbidity; Coronary Artery Disease; Cross-Sect | 2014 |
Association of low baseline free thyroxin levels with progression of coronary artery calcification over 4 years in euthyroid subjects: the Kangbuk Samsung Health Study.
Topics: Adult; Aged; Coronary Artery Disease; Disease Progression; Euthyroid Sick Syndromes; Female; Humans; | 2016 |
Relationship and prognostic importance of thyroid hormone and N-terminal pro-B-Type natriuretic peptide for patients after acute coronary syndromes: a longitudinal observational study.
Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; C-Reactive Protein; Coronary Artery Disease; Female; | 2016 |
Increased serum chitotriosidase activity following restoration of euthyroidism in patients with subclinical hypothyroidism.
Topics: Adult; Biomarkers; Case-Control Studies; Coronary Artery Disease; Female; Hexosaminidases; Hormone R | 2008 |
Thyroid hormone and coronary artery disease: from clinical correlations to prognostic implications.
Topics: Aged; Biomarkers; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Euthyroid | 2009 |
Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Apolipoprotein B-48; Atherosclerosis; Case-Control Studi | 2012 |
Association between low serum free thyroxine concentrations and coronary artery calcification in healthy euthyroid subjects.
Topics: Adult; Aged; Atherosclerosis; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans; Male | 2012 |
Low serum free triiodothyronine levels are associated with the presence and severity of coronary artery disease in the euthyroid patients: an observational study.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Coronary Angiography; Coronary Artery Disease; Female; H | 2012 |
Fatigue in patients with coronary artery disease: association with thyroid axis hormones and cortisol.
Topics: Adrenal Glands; Coronary Artery Disease; Cross-Sectional Studies; Exercise Test; Exercise Tolerance; | 2012 |
Reductuon of serum-cholesterol by dextro-thyroxine in men with coronary heart-disease.
Topics: Anti-Arrhythmia Agents; Cardiotonic Agents; Cholesterol; Coronary Artery Disease; Coronary Disease; | 1961 |
The effects of various serum cholesterol lowering procedures and agents in patients with coronary artery disease.
Topics: Alcohols; Cholesterol; Coronary Artery Disease; Coronary Disease; Humans; Lipotropic Agents; Thyroxi | 1962 |
Observations on sodium D-thyroxine as a hypocholesteremic agent in persons with hypercholesteremia with and without ischemic heart disease.
Topics: Anticholesteremic Agents; Cholesterol; Coronary Artery Disease; Coronary Disease; Dextrothyroxine; H | 1962 |
Dextro-thyroxine and cholesterol. Dextrothyroxine therapy in patients with hypercholesterolemia and arteriosclerotic heart disease.
Topics: Cholesterol; Coronary Artery Disease; Coronary Disease; Dextrothyroxine; Humans; Hypercholesterolemi | 1962 |
[Effect of choline and thyroxin on recurrent development of coronary atherosclerosis].
Topics: Arteriosclerosis; Choline; Coronary Artery Disease; Coronary Disease; Humans; Thyroxine | 1955 |
The reduction of serum cholesterol with thyroid analogues. II. The reduction of serum cholesterol by dextro-thyroxine in hypercholesterolemic patients with coronary heart disease.
Topics: Cholesterol; Coronary Artery Disease; Coronary Disease; Humans; Inorganic Chemicals; Organic Chemica | 1961 |
Thyroid function is associated with presence and severity of coronary atherosclerosis.
Topics: Adult; Aged; Aged, 80 and over; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studi | 2003 |
[Changes of thyroid hormone levels in the progression of coronary arteriosclerosis].
Topics: Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Disease Progression; Heart Fail | 2004 |
Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients.
Topics: Aged; Angina Pectoris; C-Reactive Protein; Coronary Artery Disease; Female; Humans; Lipids; Male; Mi | 2007 |
[Lipoprotein(a)--a risk factor for coronary sclerosis in patients with hypothyroidism].
Topics: Adult; Aged; Apolipoproteins B; Coronary Artery Disease; Female; Humans; Hypothyroidism; Lipids; Lip | 1998 |
[Coronary insufficiency and metabolic hormone ratio in patients with myocardial infarction in the course of a long prospective study].
Topics: Adult; Coronary Artery Disease; Disease Progression; Female; Glucose Tolerance Test; Humans; Hydroco | 2000 |
Coronary bypass surgery in patients on thyroxin replacement therapy.
Topics: Aged; Chronic Disease; Coronary Artery Bypass; Coronary Artery Disease; Female; Hemodynamics; Humans | 2002 |