Page last updated: 2024-11-06

thyroxine and Compensatory Hyperinsulinemia

thyroxine has been researched along with Compensatory Hyperinsulinemia in 22 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.

Research Excerpts

ExcerptRelevanceReference
"Carvedilol treatment reversed thyroxin induced hypertriglyceridemia, whereas propranolol treatment had no effect."5.34Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study. ( Bhatt, P; Goyal, R; Makwana, D; Santani, D, 2007)
" The fetal growth retardation, hyperleptinemia, hyperinsulinism, and cytokines distortions (transforming growth factor-beta; TGF-β, tumor necrosis factor-alpha; TNF-α, and interferon-γ; IFN-γ) were noticed at examined EDs if compared to the control group."3.83Gestational dexamethasone alters fetal neuroendocrine axis. ( Ahmed, RG, 2016)
"Moreover, hyperinsulinemia reduces the circulating level of serum T4 and conversion of T4 to T3, mimicking hypothyroidism, because thyroid hormones are necessary for the maturation of chondrocytes."1.46Serum insulin in pathogenesis and treatment of osteoarthritis. ( Askari, A; Bahramali, E; Ehrampoush, E; Farjam, M; Homayounfar, R, 2017)
"Insulin sensitivity was measured by intravenous glucose tolerance testing, hyperinsulinemic-euglycemic clamps, and insulin-stimulated insulin receptor and protein kinase B phosphorylation levels in muscle."1.35High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates. ( Flynn, DM; Jones, KL; Kavanagh, K; Shadoan, MK; Wagner, JD; Zhang, L, 2008)
"Thyrotoxicosis is known to induce a broad range of changes in carbohydrate metabolism."1.35Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. ( Ackermans, MT; Boelen, A; Fliers, E; Kalsbeek, A; Klieverik, LP; Sauerwein, HP, 2008)
"Carvedilol treatment reversed thyroxin induced hypertriglyceridemia, whereas propranolol treatment had no effect."1.34Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study. ( Bhatt, P; Goyal, R; Makwana, D; Santani, D, 2007)
"A relationship between hyperinsulinemia and decreased serum sex hormone-binding globulin (SHBG) has been described in adults."1.31Sex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children. ( Cañete, R; Gascón, F; Martos, R; Montilla, P; Ríos, R; Ruz, FJ; Valle, M, 2000)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19908 (36.36)18.7374
1990's1 (4.55)18.2507
2000's9 (40.91)29.6817
2010's4 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bas, S1
Guran, T1
Atay, Z1
Haliloglu, B1
Abalı, S1
Turan, S1
Bereket, A1
Ahmed, RG1
Askari, A1
Ehrampoush, E1
Homayounfar, R1
Bahramali, E1
Farjam, M1
Kavanagh, K1
Jones, KL1
Zhang, L1
Flynn, DM1
Shadoan, MK1
Wagner, JD1
Praveen, EP1
Khurana, ML1
Kulshreshtha, B1
Dwivedi, SN1
Prabhakaran, D1
Khadgawat, R1
Gupta, N1
Kumar, G1
Ammini, AC1
Rochon, C1
Tauveron, I1
Dejax, C1
Benoit, P1
Capitan, P1
Fabricio, A1
Berry, C1
Champredon, C1
Thieblot, P1
Grizard, J1
Riis, AL1
Hansen, TK1
Møller, N1
Weeke, J1
Jørgensen, JO1
LEAK, D1
BRUNJES, S1
JOHNS, VJ1
STARR, P1
UTIGER, RD1
Velija-Asimi, Z1
Karamehic, J1
Bhatt, P1
Makwana, D1
Santani, D1
Goyal, R1
Klieverik, LP1
Sauerwein, HP1
Ackermans, MT1
Boelen, A1
Kalsbeek, A1
Fliers, E1
Kolodin, VA1
Gasilin, VS1
Baranov, VA1
Antonov, IuS1
Dokuchaeva, EA1
Brook, CG1
Chapa, AM1
Fernandez, JM1
Thompson, DL1
Tempelman, RJ1
Berrio, LF1
Croom, WJ1
Hagler, WM1
de L Costello, AM1
Pal, DK1
Manandhar, DS1
Rajbhandari, S1
Land, JM1
Patel, N1
Gascón, F1
Valle, M1
Martos, R1
Ruz, FJ1
Ríos, R1
Montilla, P1
Cañete, R1
Chen, AS1
Marsh, DJ1
Trumbauer, ME1
Frazier, EG1
Guan, XM1
Yu, H1
Rosenblum, CI1
Vongs, A1
Feng, Y1
Cao, L1
Metzger, JM1
Strack, AM1
Camacho, RE1
Mellin, TN1
Nunes, CN1
Min, W1
Fisher, J1
Gopal-Truter, S1
MacIntyre, DE1
Chen, HY1
Van der Ploeg, LH1
Kissebah, AH1
Schectman, G1
Okamoto, H1
Hinman, DJ1
Griffith, DR1
Kreisberg, RA1
Owen, WC1
Siegal, AM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Corneal Tomographic Analysis Among Patients With Thyroid Gland Dysfunction.[NCT04433936]100 participants (Actual)Observational2018-02-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for thyroxine and Compensatory Hyperinsulinemia

ArticleYear
Hormones and lipoprotein metabolism.
    Bailliere's clinical endocrinology and metabolism, 1987, Volume: 1, Issue:3

    Topics: Catecholamines; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glucagon; Glucocortico

1987
[On the regulatory mechanism of kynurenine metabolism in mitochondrial membranes with special reference to the problem of hyperinsulinemia or diabetic state (author's transl)].
    Seikagaku. The Journal of Japanese Biochemical Society, 1974, Sep-25, Volume: 46, Issue:9

    Topics: Animals; Diabetes Mellitus; Electron Transport; Female; Flavin-Adenine Dinucleotide; Glucose; Humans

1974
Nutrition and endocrine disease.
    The Medical clinics of North America, 1970, Volume: 54, Issue:6

    Topics: Acromegaly; Adipose Tissue; Adrenal Gland Diseases; Animals; Body Composition; Diabetes Mellitus; En

1970

Trials

1 trial available for thyroxine and Compensatory Hyperinsulinemia

ArticleYear
Hyperthyroidism is associated with suppressed circulating ghrelin levels.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:2

    Topics: Adult; Body Composition; Energy Metabolism; Fasting; Female; Ghrelin; Glucose Clamp Technique; Human

2003

Other Studies

18 other studies available for thyroxine and Compensatory Hyperinsulinemia

ArticleYear
Premature pubarche, hyperinsulinemia and hypothyroxinemia: novel manifestations of congenital portosystemic shunts (Abernethy malformation) in children.
    Hormone research in paediatrics, 2015, Volume: 83, Issue:4

    Topics: Adolescent; Child; Female; Humans; Hyperinsulinism; Puberty, Precocious; Thyroxine; Vascular Malform

2015
Gestational dexamethasone alters fetal neuroendocrine axis.
    Toxicology letters, 2016, Sep-06, Volume: 258

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dexamethasone; Endocrine Disruptors; Female; Fetal Dev

2016
Serum insulin in pathogenesis and treatment of osteoarthritis.
    Medical hypotheses, 2017, Volume: 99

    Topics: Adipokines; Cartilage; Cell Differentiation; Cell Proliferation; Chondrocytes; Disease Progression;

2017
High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates.
    Nutrition research (New York, N.Y.), 2008, Volume: 28, Issue:6

    Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Cholesterol, HDL; Estrogen Receptor Modulators; Fe

2008
Plasma testosterone in adult normoglycaemic men: impact of hyperinsulinaemia.
    Andrologia, 2012, Volume: 44, Issue:5

    Topics: Adult; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Humans; Hydroc

2012
Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism.
    Clinical science (London, England : 1979), 2003, Volume: 104, Issue:1

    Topics: Adult; Amino Acids; Blood Glucose; Drug Administration Schedule; Female; Glucose; Glucose Clamp Tech

2003
LETTER TO THE EDITOR: EXCESS THYROID MEDICATION AND ADRENAL MEDULLARY RESPONSE TO INSULIN HYPOGLYCEMIA.
    The Journal of clinical endocrinology and metabolism, 1963, Volume: 23

    Topics: Adrenal Medulla; Epinephrine; Humans; Hyperinsulinism; Hypoglycemia; Hypothyroidism; Insulins; Thyro

1963
RADIOIMMUNOASSAY OF HUMAN PLASMA THYROTROPIN.
    The Journal of clinical investigation, 1965, Volume: 44

    Topics: Antigen-Antibody Reactions; Chromatography; Chromatography, Gel; Drug Therapy; Electrophoresis; Huma

1965
The effects of treatment of subclinical hypothyroidism on metabolic control and hyperinsulinemia.
    Medicinski arhiv, 2007, Volume: 61, Issue:1

    Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Glucose Intolerance; Glycated Hemoglobin;

2007
Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study.
    Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Appetite; Blood Glucose; Blood Pressure; Body Mass Index; Body

2007
Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats.
    American journal of physiology. Endocrinology and metabolism, 2008, Volume: 294, Issue:3

    Topics: Animals; Autonomic Denervation; Blood Glucose; Glucose; Glucose Clamp Technique; Hyperinsulinism; In

2008
[Role of excessive body weight and hormonal changes in the development of the main types of hyperlipoproteinemia].
    Kardiologiia, 1984, Volume: 24, Issue:11

    Topics: Adrenocortical Hyperfunction; Adult; Growth Hormone; Humans; Hydrocortisone; Hyperinsulinism; Hyperl

1984
Obesity: the fat child.
    British journal of hospital medicine, 1980, Volume: 24, Issue:6

    Topics: Adipose Tissue; Adult; Child; Child Development; Child, Preschool; Diagnosis, Differential; Diet, Re

1980
Endocrine and metabolic response to muscarinic stimulation and inhibition in the ruminant: effects of slaframine.
    Journal of animal science, 1995, Volume: 73, Issue:12

    Topics: Alkaloids; Animals; Blood Glucose; Endocrine Glands; Fatty Acids, Nonesterified; Female; Goat Diseas

1995
Neonatal hypoglycaemia in Nepal 2. Availability of alternative fuels.
    Archives of disease in childhood. Fetal and neonatal edition, 2000, Volume: 82, Issue:1

    Topics: Age Factors; Blood Glucose; Cross-Sectional Studies; Energy Metabolism; Fatty Acids, Nonesterified;

2000
Sex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children.
    European journal of endocrinology, 2000, Volume: 143, Issue:1

    Topics: Biomarkers; Blood Glucose; Body Mass Index; Child; Estradiol; Female; Humans; Hyperinsulinism; Insul

2000
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass.
    Nature genetics, 2000, Volume: 26, Issue:1

    Topics: Adipose Tissue; Age Factors; alpha-MSH; Animals; Blotting, Southern; Body Temperature; Body Weight;

2000
Effects of ventromedial hypothalamic lesions on thyroid secretion rate in rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1973, Volume: 5, Issue:1

    Topics: Animals; Body Weight; Growth Hormone; Hyperinsulinism; Hypothalamus; Iodine Isotopes; Lipid Metaboli

1973