Page last updated: 2024-11-06

thyroxine and Combat Disorders

thyroxine has been researched along with Combat Disorders in 2 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Combat Disorders: Neurotic reactions to unusual, severe, or overwhelming military stress.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mason, J2
Southwick, S2
Yehuda, R2
Wang, S2
Riney, S2
Bremner, D1
Johnson, D1
Lubin, H1
Blake, D1
Zhou, G1
Charney, D1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparing Virtual Reality Exposure Therapy to Prolonged Exposure in the Treatment of Soldiers With Post Traumatic Stress Disorder (PTSD)[NCT01459705]162 participants (Actual)Interventional2011-10-31Completed
Comparing Virtual Reality Exposure Therapy to Prolonged Exposure in the Treatment of Soldiers With PTSD[NCT01193725]162 participants (Actual)Interventional2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) PTSD criteria in terms of frequency and intensity. We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: Screening Visit (Day 1)

Interventionunits on scale (Mean)
Prolonged Exposure Therapy (PE)78.28
Virtual Reality Exposure Therapy (VRET)80.44
Waitlist78.89

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all DSM-IV PTSD criteria in terms of frequency and intensity. Scores are computed for Intrusion, Avoidance and Hyperarousal symptom clusters, as well as a Total score.We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: 12 week follow up

Interventionunits on a scale (Mean)
Prolonged Exposure Therapy (PE)36.63
Virtual Reality Exposure Therapy (VRET)55.88

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all DSM-IV PTSD criteria in terms of frequency and intensity. Scores are computed for Intrusion, Avoidance and Hyperarousal symptom clusters, as well as a Total score.We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: 2.5 weeks (or after treatment session 5)

Interventionunits on a scale (Mean)
Prolonged Exposure Therapy (PE)65.03
Virtual Reality Exposure Therapy (VRET)71.19
Waitlist74.73

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all DSM-IV PTSD criteria in terms of frequency and intensity. Scores are computed for Intrusion, Avoidance and Hyperarousal symptom clusters, as well as a Total score.We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: 26 Week follow up

Interventionunits on a scale (Mean)
Prolonged Exposure Therapy (PE)38.33
Virtual Reality Exposure Therapy (VRET)54.47

Clinician-Administered PTSD Scale (CAPS)

The CAPS is a structured interview that assesses all DSM-IV PTSD criteria in terms of frequency and intensity. Scores are computed for Intrusion, Avoidance and Hyperarousal symptom clusters, as well as a Total score.We used total scores as the primary outcome. Minimum possible score was 0, maximum possible score was 136. Higher scores indicated higher levels of symptoms. (NCT01459705)
Timeframe: 5 weeks (or after treatment session 10)

Interventionunits on a scale (Mean)
Prolonged Exposure Therapy (PE)44.28
Virtual Reality Exposure Therapy (VRET)57.07
Waitlist68.06

Other Studies

2 other studies available for thyroxine and Combat Disorders

ArticleYear
Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder.
    Archives of general psychiatry, 1994, Volume: 51, Issue:8

    Topics: Adult; Combat Disorders; Comorbidity; Follow-Up Studies; Humans; Hyperthyroidism; Male; Pilot Projec

1994
Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder.
    Archives of general psychiatry, 1994, Volume: 51, Issue:8

    Topics: Adult; Combat Disorders; Comorbidity; Follow-Up Studies; Humans; Hyperthyroidism; Male; Pilot Projec

1994
Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder.
    Archives of general psychiatry, 1994, Volume: 51, Issue:8

    Topics: Adult; Combat Disorders; Comorbidity; Follow-Up Studies; Humans; Hyperthyroidism; Male; Pilot Projec

1994
Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder.
    Archives of general psychiatry, 1994, Volume: 51, Issue:8

    Topics: Adult; Combat Disorders; Comorbidity; Follow-Up Studies; Humans; Hyperthyroidism; Male; Pilot Projec

1994
Relationships between hormonal profile and novelty seeking in combat-related posttraumatic stress disorder.
    Biological psychiatry, 1997, Jan-15, Volume: 41, Issue:2

    Topics: Adult; Arousal; Combat Disorders; Hormones; Humans; Hydrocortisone; Middle Aged; Norepinephrine; Per

1997