Page last updated: 2024-11-06

thyroxine and Colorectal Neoplasms

thyroxine has been researched along with Colorectal Neoplasms in 13 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

Research Excerpts

ExcerptRelevanceReference
"Patients with documented metastatic colorectal cancer and progression of disease during or within 3 months after the last standard therapy, with no evidence and history of previous thyroid disease were enrolled."5.46Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link? ( Madeddu, C; Mariotti, S; Massa, E; Massidda, M; Pani, F; Pusceddu, V; Puzzoni, M; Scartozzi, M, 2017)
"In conclusion, T4 promoted colorectal cancer cell proliferation which could be repressed by tetrac and NDAT."5.43The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status. ( Chin, YT; Davis, PJ; Incerpi, S; Lee, YS; Lin, HY; Liu, LF; Lu, YT; Pedersen, JZ; Shih, A; Wei, PL; Wu, HC; Yang, YSH, 2016)
" Therefore, we aimed to investigate the product of this enzyme, reverse triiodothyronine (rT3) in serum of newly diagnosed colorectal cancer (CRC) patients."4.02Colorectal cancer causes alteration of thyroid hormone profile in newly diagnosed patients. ( Ghorbani, A; Pourvali, K; Shimi, G; Zand, H, 2021)
"Patients with documented metastatic colorectal cancer and progression of disease during or within 3 months after the last standard therapy, with no evidence and history of previous thyroid disease were enrolled."1.46Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link? ( Madeddu, C; Mariotti, S; Massa, E; Massidda, M; Pani, F; Pusceddu, V; Puzzoni, M; Scartozzi, M, 2017)
"Associations with cancer-related deaths were also explored."1.46Higher thyrotropin concentration is associated with increased incidence of colorectal cancer in older men. ( Alfonso, H; Chan, YX; Chubb, SA; Fegan, PG; Flicker, L; Golledge, J; Hankey, GJ; Yeap, BB, 2017)
"In conclusion, T4 promoted colorectal cancer cell proliferation which could be repressed by tetrac and NDAT."1.43The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status. ( Chin, YT; Davis, PJ; Incerpi, S; Lee, YS; Lin, HY; Liu, LF; Lu, YT; Pedersen, JZ; Shih, A; Wei, PL; Wu, HC; Yang, YSH, 2016)
"Thyroid function in colorectal cancer patients receiving fluoropyrimidine-based chemotherapy with or without bevacizumab was evaluated at baseline and monthly."1.39Hypothyroidism in patients with colorectal carcinoma treated with fluoropyrimidines. ( Chayahara, N; Fujiwara, Y; Funakoshi, Y; Kiyota, N; Minami, H; Mukohara, T; Tomioka, H, 2013)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's0 (0.00)29.6817
2010's10 (76.92)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Huang, TY1
Chang, TC2
Chin, YT5
Pan, YS1
Chang, WJ1
Liu, FC1
Hastuti, ED1
Chiu, SJ1
Wang, SH2
Changou, CA2
Li, ZL1
Chen, YR4
Chu, HR1
Shih, YJ4
Cheng, RH1
Wu, A1
Lin, HY5
Wang, K2
Whang-Peng, J3
Mousa, SA1
Davis, PJ5
Shimi, G1
Zand, H1
Pourvali, K1
Ghorbani, A1
Pani, F1
Massidda, M1
Pusceddu, V1
Puzzoni, M1
Massa, E1
Madeddu, C1
Scartozzi, M1
Mariotti, S1
Lee, YS2
Nana, AW3
Wu, HC2
Yang, YSH2
Wu, SY1
Yang, YS2
Cheng, TM1
Ho, Y1
Li, WS1
Liao, YM2
Liu, YR1
Pedersen, J1
Incerpi, S2
Hercbergs, A1
Liu, LF2
Wang, LS1
Stain, SC1
Shih, A2
Wu, CH1
Zohreh, B1
Masoumeh, V1
Fakhraddin, N1
Omrani, GHR1
Fujiwara, Y1
Chayahara, N1
Mukohara, T1
Kiyota, N1
Tomioka, H1
Funakoshi, Y1
Minami, H1
Wei, PL1
Lu, YT1
Pedersen, JZ1
Chan, YX1
Alfonso, H1
Chubb, SA1
Fegan, PG1
Hankey, GJ1
Golledge, J1
Flicker, L1
Yeap, BB1
Rennert, G1
Rennert, HS1
Pinchev, M1
Gruber, SB1
Friedman, GD1
Schwalbe, JS1
Habel, LA1
Murai, H1
Murakami, S1
Ishida, K1
Sugawara, M1

Other Studies

13 other studies available for thyroxine and Colorectal Neoplasms

ArticleYear
NDAT Targets PI3K-Mediated PD-L1 Upregulation to Reduce Proliferation in Gefitinib-Resistant Colorectal Cancer.
    Cells, 2020, 08-03, Volume: 9, Issue:8

    Topics: Animals; Antineoplastic Agents; B7-H1 Antigen; Cell Proliferation; Colorectal Neoplasms; Drug Resist

2020
Colorectal cancer causes alteration of thyroid hormone profile in newly diagnosed patients.
    Expert review of endocrinology & metabolism, 2021, Volume: 16, Issue:5

    Topics: Colorectal Neoplasms; Cross-Sectional Studies; Humans; Thyroid Hormones; Thyroxine; Triiodothyronine

2021
Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link?
    European journal of endocrinology, 2017, Volume: 177, Issue:1

    Topics: Adenocarcinoma; Aged; Autoimmune Diseases; Cohort Studies; Colorectal Neoplasms; Fatigue; Female; Ho

2017
Thyroid Hormone Promotes β-Catenin Activation and Cell Proliferation in Colorectal Cancer.
    Hormones & cancer, 2018, Volume: 9, Issue:3

    Topics: beta Catenin; Carcinogenesis; Cell Proliferation; Colorectal Neoplasms; Cyclin D1; Gene Expression R

2018
Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers.
    Hormones & cancer, 2018, Volume: 9, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Colorectal Neoplasms; Disease Mo

2018
Enhancement by Nano-Diamino-Tetrac of Antiproliferative Action of Gefitinib on Colorectal Cancer Cells: Mediation by EGFR Sialylation and PI3K Activation.
    Hormones & cancer, 2018, Volume: 9, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Colorectal N

2018
Apigenin-mediated Alterations in Viability and Senescence of SW480 Colorectal Cancer Cells Persist in The Presence of L-thyroxine.
    Anti-cancer agents in medicinal chemistry, 2019, Volume: 19, Issue:12

    Topics: Antineoplastic Agents; Apigenin; Apoptosis; Cell Proliferation; Cell Survival; Cellular Senescence;

2019
Hypothyroidism in patients with colorectal carcinoma treated with fluoropyrimidines.
    Oncology reports, 2013, Volume: 30, Issue:4

    Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Che

2013
The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status.
    Steroids, 2016, Volume: 111

    Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cetuximab; Colorecta

2016
Higher thyrotropin concentration is associated with increased incidence of colorectal cancer in older men.
    Clinical endocrinology, 2017, Volume: 86, Issue:2

    Topics: Age Factors; Aged; Colorectal Neoplasms; Female; Humans; Incidence; Lung Neoplasms; Male; Neoplasms;

2017
A case-control study of levothyroxine and the risk of colorectal cancer.
    Journal of the National Cancer Institute, 2010, Apr-21, Volume: 102, Issue:8

    Topics: Aged; Case-Control Studies; Colorectal Neoplasms; Confounding Factors, Epidemiologic; Female; Humans

2010
Re: a case-control study of levothyroxine and the risk of colorectal cancer.
    Journal of the National Cancer Institute, 2011, Nov-02, Volume: 103, Issue:21

    Topics: Colorectal Neoplasms; Female; Humans; Male; Thyroxine

2011
Elevated serum interleukin-6 and decreased thyroid hormone levels in postoperative patients and effects of IL-6 on thyroid cell function in vitro.
    Thyroid : official journal of the American Thyroid Association, 1996, Volume: 6, Issue:6

    Topics: Aged; Cholecystectomy; Colorectal Neoplasms; Esophageal Neoplasms; Female; Humans; Interleukin-6; Ma

1996