thyroxine has been researched along with Cognitive Dysfunction in 22 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thyroid function was classified as overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism, subclinical hypothyroidism, and overt hypothyroidism based on uniform thyrotropin cutoff values and study-specific free thyroxine values." | 4.02 | Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis. ( Almeida, OP; Åsvold, BO; Aubert, CE; Bae, JB; Barnes, LE; Bauer, DC; Blauw, GJ; Brayne, C; Cappola, AR; Ceresini, G; Comijs, HC; Dartigues, JF; de Jongh, RT; Degryse, JM; den Elzen, WPJ; Dullaart, RPF; Ferrucci, L; Fink, HA; Flicker, L; Grabe, HJ; Gussekloo, J; Han, JW; Helmer, C; Huisman, M; Ikram, MA; Imaizumi, M; Jukema, JW; Kim, KW; Kuller, LH; Lopez, OL; Mooijaart, SP; Moon, JH; Moutzouri, E; Nauck, M; Parle, J; Peeters, RP; Rodondi, N; Samuels, MH; Schmidt, CO; Schminke, U; Slagboom, PE; Stordal, E; Trompet, S; Vaes, B; van Eersel, MEA; van Heemst, D; van Vliet, NA; Völzke, H; Westendorp, RGJ; Yamada, M; Yeap, BB, 2021) |
| "A prospective cohort study was conducted, in which, patients with differentiated thyroid carcinoma and benign thyroid nodules were given oral L-T4 therapy after surgery, after meeting the criteria of TSH suppression therapy and thyroxine replacement therapy, respectively, the patients were continually given L-T4 therapy for 6 and 12 months, and then, the neuropsychological test was performed." | 3.91 | Naming difficulties after thyroid stimulating hormone suppression therapy in patients with differentiated thyroid carcinoma: a prospective cohort study. ( Ai, JW; Bai, Y; Bao, W; Jin, S; Liu, Y; Yang, YT; Yong, H, 2019) |
| "To investigate the association between disease progression and subclinical hypothyroidism, a Cox regression analyses was performed in 379 patients with MCI." | 1.72 | Subclinical Hypothyroidism and Cognitive Impairment. ( Kim, S; Park, YH; Pyun, JM, 2022) |
| "Several of the cognitive impairments found on the WAIS-RC and WMS-RC tests were more frequently observed in untreated patients with PA." | 1.51 | Effect of Hormone Levels and Aging on Cognitive Function of Patients with Pituitary Adenomas Prior to Medical Treatment. ( Chen, J; Kan, W; Liu, H; Liu, Y; Luo, Z; Wang, R; Yang, K; Zhao, J; Zou, Y, 2019) |
| "Age-related cognitive decline has been associated with changes in endogenous hormones and epigenetic modification of chromatin, including histone acetylation." | 1.43 | Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a. ( Cao, L; Chen, GH; Ge, H; Jiang, W; Li, XW; Wang, F; Wu, PC, 2016) |
| "Cognitive deficits are common in Parkinson's disease (PD) patients." | 1.40 | Thyroid status and cognitive function in euthyroid patients with early Parkinson's disease. ( Cho, KH; Choi, KH; Choi, SM; Kim, BC; Kim, JT; Kim, MK; Lee, SH; Nam, TS; Park, MS, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (54.55) | 24.3611 |
| 2020's | 10 (45.45) | 2.80 |
| Authors | Studies |
|---|---|
| van Vliet, NA | 1 |
| van Heemst, D | 1 |
| Almeida, OP | 1 |
| Åsvold, BO | 1 |
| Aubert, CE | 1 |
| Bae, JB | 1 |
| Barnes, LE | 1 |
| Bauer, DC | 1 |
| Blauw, GJ | 1 |
| Brayne, C | 1 |
| Cappola, AR | 1 |
| Ceresini, G | 1 |
| Comijs, HC | 1 |
| Dartigues, JF | 1 |
| Degryse, JM | 1 |
| Dullaart, RPF | 1 |
| van Eersel, MEA | 1 |
| den Elzen, WPJ | 1 |
| Ferrucci, L | 1 |
| Fink, HA | 1 |
| Flicker, L | 1 |
| Grabe, HJ | 1 |
| Han, JW | 1 |
| Helmer, C | 1 |
| Huisman, M | 1 |
| Ikram, MA | 1 |
| Imaizumi, M | 1 |
| de Jongh, RT | 1 |
| Jukema, JW | 1 |
| Kim, KW | 1 |
| Kuller, LH | 1 |
| Lopez, OL | 1 |
| Mooijaart, SP | 1 |
| Moon, JH | 1 |
| Moutzouri, E | 1 |
| Nauck, M | 1 |
| Parle, J | 1 |
| Peeters, RP | 1 |
| Samuels, MH | 1 |
| Schmidt, CO | 1 |
| Schminke, U | 1 |
| Slagboom, PE | 1 |
| Stordal, E | 1 |
| Vaes, B | 1 |
| Völzke, H | 1 |
| Westendorp, RGJ | 1 |
| Yamada, M | 1 |
| Yeap, BB | 1 |
| Rodondi, N | 1 |
| Gussekloo, J | 1 |
| Trompet, S | 1 |
| Furuto-Kato, S | 1 |
| Araki, A | 1 |
| Chiba, Y | 1 |
| Nakamura, M | 1 |
| Shintani, M | 1 |
| Kuwahara, T | 1 |
| Yamakage, H | 1 |
| Satoh-Asahara, N | 1 |
| Tagami, T | 1 |
| Lv, J | 1 |
| Li, Y | 1 |
| Chen, J | 2 |
| Li, R | 1 |
| Bao, C | 1 |
| Ding, Z | 1 |
| Ren, W | 1 |
| Du, Z | 1 |
| Wang, S | 1 |
| Huang, Y | 1 |
| Wang, QN | 1 |
| Chen, P | 1 |
| Chen, G | 1 |
| Zhong, S | 1 |
| Chen, F | 1 |
| Ye, T | 1 |
| Gong, J | 1 |
| Tang, G | 1 |
| Pan, Y | 1 |
| Luo, Z | 2 |
| Qi, Z | 1 |
| Huang, L | 1 |
| Wang, Y | 1 |
| Pyun, JM | 1 |
| Park, YH | 1 |
| Kim, S | 1 |
| Li, LX | 1 |
| Yang, T | 1 |
| Guo, L | 1 |
| Wang, DY | 1 |
| Tang, CH | 1 |
| Li, Q | 1 |
| Yang, HM | 1 |
| Zhu, J | 1 |
| Zhang, LL | 1 |
| Liu, Y | 3 |
| Jin, S | 2 |
| Yang, YT | 2 |
| Bai, Y | 2 |
| Yong, H | 2 |
| Bao, W | 2 |
| Ge, YJ | 1 |
| Xu, W | 1 |
| Tan, CC | 1 |
| Tan, L | 1 |
| Mishra, J | 1 |
| Vishwakarma, J | 1 |
| Malik, R | 1 |
| Gupta, K | 1 |
| Pandey, R | 1 |
| Maurya, SK | 1 |
| Garg, A | 1 |
| Shukla, M | 1 |
| Chattopadhyay, N | 1 |
| Bandyopadhyay, S | 1 |
| Szlejf, C | 1 |
| Suemoto, CK | 1 |
| Janovsky, CCPS | 1 |
| Bertola, L | 1 |
| Barreto, SM | 1 |
| Lotufo, PA | 1 |
| Benseñor, IM | 1 |
| Qu, P | 1 |
| Yu, JX | 1 |
| Xia, L | 1 |
| Chen, GH | 2 |
| Quinlan, P | 1 |
| Horvath, A | 1 |
| Wallin, A | 2 |
| Svensson, J | 2 |
| Kan, W | 1 |
| Wang, R | 1 |
| Yang, K | 1 |
| Liu, H | 1 |
| Zou, Y | 1 |
| Zhao, J | 1 |
| Ai, JW | 1 |
| Formiga, F | 1 |
| Ferrer, A | 1 |
| Padros, G | 1 |
| Contra, A | 1 |
| Corbella, X | 1 |
| Pujol, R | 1 |
| Choi, SM | 1 |
| Kim, BC | 1 |
| Choi, KH | 1 |
| Nam, TS | 1 |
| Kim, JT | 1 |
| Lee, SH | 1 |
| Park, MS | 1 |
| Kim, MK | 1 |
| Cho, KH | 1 |
| Luo, M | 1 |
| Zhou, XH | 1 |
| Zou, T | 1 |
| Keyim, K | 1 |
| Dong, LM | 1 |
| de-Miranda, AS | 1 |
| Kuriyama, SN | 1 |
| da-Silva, CS | 1 |
| do-Nascimento, MS | 1 |
| Parente, TE | 1 |
| Paumgartten, FJ | 1 |
| Salerno, M | 1 |
| Capalbo, D | 1 |
| Cerbone, M | 1 |
| De Luca, F | 1 |
| Jiang, W | 1 |
| Cao, L | 1 |
| Wang, F | 1 |
| Ge, H | 1 |
| Wu, PC | 1 |
| Li, XW | 1 |
| Bojar, I | 1 |
| Stasiak, M | 1 |
| Cyniak-Magierska, A | 1 |
| Raczkiewicz, D | 1 |
| Lewiński, A | 1 |
| Johansson, P | 1 |
| Almqvist, EG | 1 |
| Johansson, JO | 1 |
| Mattsson, N | 1 |
| Hansson, O | 1 |
| Blennow, K | 1 |
| Zetterberg, H | 1 |
2 reviews available for thyroxine and Cognitive Dysfunction
| Article | Year |
|---|---|
Blood-based biomarkers in hypothalamic-pituitary axes for the risk of dementia or cognitive decline: a systematic review and meta-analysis.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognition; Cognitive Dysfunction; Dementia; Female; Humans; Hyp | 2020 |
Subclinical hypothyroidism in childhood - current knowledge and open issues.
Topics: Anticonvulsants; Antiviral Agents; Asymptomatic Diseases; Atherosclerosis; Bone Diseases, Metabolic; | 2016 |
1 trial available for thyroxine and Cognitive Dysfunction
| Article | Year |
|---|---|
Thyroid status and functional and cognitive status at baseline and survival after 3 years of follow-up: the OCTABAIX study.
Topics: Aged, 80 and over; Aging; Cognitive Dysfunction; Cohort Studies; Double-Blind Method; Female; Follow | 2014 |
19 other studies available for thyroxine and Cognitive Dysfunction
| Article | Year |
|---|---|
Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis.
Topics: Aged; Cognition; Cognitive Dysfunction; Correlation of Data; Data Analysis; Female; Humans; Hyperthy | 2021 |
Relationship between the Thyroid Function and Cognitive Impairment in the Elderly in Japan.
Topics: Aged; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; Japan; Male; Reference Values; | 2022 |
Maternal exposure to bis(2-ethylhexyl) phthalate during the thyroid hormone-dependent stage induces persistent emotional and cognitive impairment in middle-aged offspring mice.
Topics: Animals; Cognitive Dysfunction; Diethylhexyl Phthalate; Female; Humans; Male; Maternal Exposure; Mic | 2022 |
Thyroid hormones disturbances, cognitive deficits and abnormal dynamic functional connectivity variability of the amygdala in unmedicated bipolar disorder.
Topics: Amygdala; Bipolar Disorder; Cognition; Cognitive Dysfunction; Humans; Magnetic Resonance Imaging; Th | 2022 |
Subclinical Hypothyroidism and Cognitive Impairment.
Topics: Aged; Cognitive Dysfunction; Disease Progression; Humans; Hypothyroidism; Middle Aged; Thyroid Disea | 2022 |
Serum tau levels are increased in patients with hyperthyroidism.
Topics: Adult; Alzheimer Disease; Cognitive Dysfunction; Female; Humans; Hyperthyroidism; Male; Middle Aged; | 2020 |
Cognitive dysfunction associated with activation of the mTOR signaling pathway after TSH suppression therapy in rats.
Topics: Animals; CA1 Region, Hippocampal; Cognition; Cognitive Dysfunction; Dose-Response Relationship, Drug | 2020 |
Hypothyroidism Induces Interleukin-1-Dependent Autophagy Mechanism as a Key Mediator of Hippocampal Neuronal Apoptosis and Cognitive Decline in Postnatal Rats.
Topics: Animals; Animals, Newborn; Apoptosis; Autophagy; Cognitive Dysfunction; Hippocampus; Hypothyroidism; | 2021 |
Subtle Thyroid Dysfunction Is Not Associated with Cognitive Decline: Results from the ELSA-Brasil.
Topics: Aged; Brazil; Cognition; Cognitive Dysfunction; Comorbidity; Female; Follow-Up Studies; Humans; Male | 2021 |
Cognitive Performance and the Alteration of Neuroendocrine Hormones in Chronic Tension-Type Headache.
Topics: Adrenocorticotropic Hormone; Adult; Case-Control Studies; Chronic Disease; Cognition; Cognitive Dysf | 2018 |
Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cognitive Dysfunction; Dementia; Dementia, Vascular; Female; Follow-Up Stud | 2019 |
Effect of Hormone Levels and Aging on Cognitive Function of Patients with Pituitary Adenomas Prior to Medical Treatment.
Topics: Adenoma; Adolescent; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Case-Control Studies; Co | 2019 |
Naming difficulties after thyroid stimulating hormone suppression therapy in patients with differentiated thyroid carcinoma: a prospective cohort study.
Topics: Adult; Anomia; Carcinoma; Cognitive Dysfunction; Female; Hormone Replacement Therapy; Humans; Male; | 2019 |
Thyroid status and cognitive function in euthyroid patients with early Parkinson's disease.
Topics: Aged; Cognition; Cognitive Dysfunction; Executive Function; Female; Humans; Male; Middle Aged; Neuro | 2014 |
Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment.
Topics: Adult; Cognitive Dysfunction; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; H | 2015 |
Thyroid hormone disruption and cognitive impairment in rats exposed to PBDE during postnatal development.
Topics: Animals; Animals, Newborn; Brain; Cognitive Dysfunction; Cytochrome P-450 CYP1A1; Cytochrome P-450 C | 2016 |
Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a.
Topics: Acetylation; Aging; Animals; Behavior Rating Scale; Benzhydryl Compounds; Cognitive Dysfunction; Dis | 2016 |
Cognitive Function, APOE Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland.
Topics: Alleles; Apolipoprotein E4; Apolipoproteins E; Autoantibodies; Cognition; Cognitive Dysfunction; Fem | 2016 |
Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Female; Humans; Male; Neuropsycho | 2013 |