Page last updated: 2024-11-06

thyroxine and Cognitive Dysfunction

thyroxine has been researched along with Cognitive Dysfunction in 22 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.

Research Excerpts

ExcerptRelevanceReference
"Thyroid function was classified as overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism, subclinical hypothyroidism, and overt hypothyroidism based on uniform thyrotropin cutoff values and study-specific free thyroxine values."4.02Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis. ( Almeida, OP; Åsvold, BO; Aubert, CE; Bae, JB; Barnes, LE; Bauer, DC; Blauw, GJ; Brayne, C; Cappola, AR; Ceresini, G; Comijs, HC; Dartigues, JF; de Jongh, RT; Degryse, JM; den Elzen, WPJ; Dullaart, RPF; Ferrucci, L; Fink, HA; Flicker, L; Grabe, HJ; Gussekloo, J; Han, JW; Helmer, C; Huisman, M; Ikram, MA; Imaizumi, M; Jukema, JW; Kim, KW; Kuller, LH; Lopez, OL; Mooijaart, SP; Moon, JH; Moutzouri, E; Nauck, M; Parle, J; Peeters, RP; Rodondi, N; Samuels, MH; Schmidt, CO; Schminke, U; Slagboom, PE; Stordal, E; Trompet, S; Vaes, B; van Eersel, MEA; van Heemst, D; van Vliet, NA; Völzke, H; Westendorp, RGJ; Yamada, M; Yeap, BB, 2021)
"A prospective cohort study was conducted, in which, patients with differentiated thyroid carcinoma and benign thyroid nodules were given oral L-T4 therapy after surgery, after meeting the criteria of TSH suppression therapy and thyroxine replacement therapy, respectively, the patients were continually given L-T4 therapy for 6 and 12 months, and then, the neuropsychological test was performed."3.91Naming difficulties after thyroid stimulating hormone suppression therapy in patients with differentiated thyroid carcinoma: a prospective cohort study. ( Ai, JW; Bai, Y; Bao, W; Jin, S; Liu, Y; Yang, YT; Yong, H, 2019)
"To investigate the association between disease progression and subclinical hypothyroidism, a Cox regression analyses was performed in 379 patients with MCI."1.72Subclinical Hypothyroidism and Cognitive Impairment. ( Kim, S; Park, YH; Pyun, JM, 2022)
"Several of the cognitive impairments found on the WAIS-RC and WMS-RC tests were more frequently observed in untreated patients with PA."1.51Effect of Hormone Levels and Aging on Cognitive Function of Patients with Pituitary Adenomas Prior to Medical Treatment. ( Chen, J; Kan, W; Liu, H; Liu, Y; Luo, Z; Wang, R; Yang, K; Zhao, J; Zou, Y, 2019)
"Age-related cognitive decline has been associated with changes in endogenous hormones and epigenetic modification of chromatin, including histone acetylation."1.43Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a. ( Cao, L; Chen, GH; Ge, H; Jiang, W; Li, XW; Wang, F; Wu, PC, 2016)
"Cognitive deficits are common in Parkinson's disease (PD) patients."1.40Thyroid status and cognitive function in euthyroid patients with early Parkinson's disease. ( Cho, KH; Choi, KH; Choi, SM; Kim, BC; Kim, JT; Kim, MK; Lee, SH; Nam, TS; Park, MS, 2014)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's12 (54.55)24.3611
2020's10 (45.45)2.80

Authors

AuthorsStudies
van Vliet, NA1
van Heemst, D1
Almeida, OP1
Åsvold, BO1
Aubert, CE1
Bae, JB1
Barnes, LE1
Bauer, DC1
Blauw, GJ1
Brayne, C1
Cappola, AR1
Ceresini, G1
Comijs, HC1
Dartigues, JF1
Degryse, JM1
Dullaart, RPF1
van Eersel, MEA1
den Elzen, WPJ1
Ferrucci, L1
Fink, HA1
Flicker, L1
Grabe, HJ1
Han, JW1
Helmer, C1
Huisman, M1
Ikram, MA1
Imaizumi, M1
de Jongh, RT1
Jukema, JW1
Kim, KW1
Kuller, LH1
Lopez, OL1
Mooijaart, SP1
Moon, JH1
Moutzouri, E1
Nauck, M1
Parle, J1
Peeters, RP1
Samuels, MH1
Schmidt, CO1
Schminke, U1
Slagboom, PE1
Stordal, E1
Vaes, B1
Völzke, H1
Westendorp, RGJ1
Yamada, M1
Yeap, BB1
Rodondi, N1
Gussekloo, J1
Trompet, S1
Furuto-Kato, S1
Araki, A1
Chiba, Y1
Nakamura, M1
Shintani, M1
Kuwahara, T1
Yamakage, H1
Satoh-Asahara, N1
Tagami, T1
Lv, J1
Li, Y1
Chen, J2
Li, R1
Bao, C1
Ding, Z1
Ren, W1
Du, Z1
Wang, S1
Huang, Y1
Wang, QN1
Chen, P1
Chen, G1
Zhong, S1
Chen, F1
Ye, T1
Gong, J1
Tang, G1
Pan, Y1
Luo, Z2
Qi, Z1
Huang, L1
Wang, Y1
Pyun, JM1
Park, YH1
Kim, S1
Li, LX1
Yang, T1
Guo, L1
Wang, DY1
Tang, CH1
Li, Q1
Yang, HM1
Zhu, J1
Zhang, LL1
Liu, Y3
Jin, S2
Yang, YT2
Bai, Y2
Yong, H2
Bao, W2
Ge, YJ1
Xu, W1
Tan, CC1
Tan, L1
Mishra, J1
Vishwakarma, J1
Malik, R1
Gupta, K1
Pandey, R1
Maurya, SK1
Garg, A1
Shukla, M1
Chattopadhyay, N1
Bandyopadhyay, S1
Szlejf, C1
Suemoto, CK1
Janovsky, CCPS1
Bertola, L1
Barreto, SM1
Lotufo, PA1
Benseñor, IM1
Qu, P1
Yu, JX1
Xia, L1
Chen, GH2
Quinlan, P1
Horvath, A1
Wallin, A2
Svensson, J2
Kan, W1
Wang, R1
Yang, K1
Liu, H1
Zou, Y1
Zhao, J1
Ai, JW1
Formiga, F1
Ferrer, A1
Padros, G1
Contra, A1
Corbella, X1
Pujol, R1
Choi, SM1
Kim, BC1
Choi, KH1
Nam, TS1
Kim, JT1
Lee, SH1
Park, MS1
Kim, MK1
Cho, KH1
Luo, M1
Zhou, XH1
Zou, T1
Keyim, K1
Dong, LM1
de-Miranda, AS1
Kuriyama, SN1
da-Silva, CS1
do-Nascimento, MS1
Parente, TE1
Paumgartten, FJ1
Salerno, M1
Capalbo, D1
Cerbone, M1
De Luca, F1
Jiang, W1
Cao, L1
Wang, F1
Ge, H1
Wu, PC1
Li, XW1
Bojar, I1
Stasiak, M1
Cyniak-Magierska, A1
Raczkiewicz, D1
Lewiński, A1
Johansson, P1
Almqvist, EG1
Johansson, JO1
Mattsson, N1
Hansson, O1
Blennow, K1
Zetterberg, H1

Reviews

2 reviews available for thyroxine and Cognitive Dysfunction

ArticleYear
Blood-based biomarkers in hypothalamic-pituitary axes for the risk of dementia or cognitive decline: a systematic review and meta-analysis.
    Aging, 2020, 10-26, Volume: 12, Issue:20

    Topics: Aged; Aged, 80 and over; Biomarkers; Cognition; Cognitive Dysfunction; Dementia; Female; Humans; Hyp

2020
Subclinical hypothyroidism in childhood - current knowledge and open issues.
    Nature reviews. Endocrinology, 2016, Volume: 12, Issue:12

    Topics: Anticonvulsants; Antiviral Agents; Asymptomatic Diseases; Atherosclerosis; Bone Diseases, Metabolic;

2016

Trials

1 trial available for thyroxine and Cognitive Dysfunction

ArticleYear
Thyroid status and functional and cognitive status at baseline and survival after 3 years of follow-up: the OCTABAIX study.
    European journal of endocrinology, 2014, Volume: 170, Issue:1

    Topics: Aged, 80 and over; Aging; Cognitive Dysfunction; Cohort Studies; Double-Blind Method; Female; Follow

2014

Other Studies

19 other studies available for thyroxine and Cognitive Dysfunction

ArticleYear
Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis.
    JAMA internal medicine, 2021, 11-01, Volume: 181, Issue:11

    Topics: Aged; Cognition; Cognitive Dysfunction; Correlation of Data; Data Analysis; Female; Humans; Hyperthy

2021
Relationship between the Thyroid Function and Cognitive Impairment in the Elderly in Japan.
    Internal medicine (Tokyo, Japan), 2022, Oct-15, Volume: 61, Issue:20

    Topics: Aged; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; Japan; Male; Reference Values;

2022
Maternal exposure to bis(2-ethylhexyl) phthalate during the thyroid hormone-dependent stage induces persistent emotional and cognitive impairment in middle-aged offspring mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022, Volume: 163

    Topics: Animals; Cognitive Dysfunction; Diethylhexyl Phthalate; Female; Humans; Male; Maternal Exposure; Mic

2022
Thyroid hormones disturbances, cognitive deficits and abnormal dynamic functional connectivity variability of the amygdala in unmedicated bipolar disorder.
    Journal of psychiatric research, 2022, Volume: 150

    Topics: Amygdala; Bipolar Disorder; Cognition; Cognitive Dysfunction; Humans; Magnetic Resonance Imaging; Th

2022
Subclinical Hypothyroidism and Cognitive Impairment.
    Journal of Alzheimer's disease : JAD, 2022, Volume: 88, Issue:2

    Topics: Aged; Cognitive Dysfunction; Disease Progression; Humans; Hypothyroidism; Middle Aged; Thyroid Disea

2022
Serum tau levels are increased in patients with hyperthyroidism.
    Neuroscience letters, 2020, 06-11, Volume: 729

    Topics: Adult; Alzheimer Disease; Cognitive Dysfunction; Female; Humans; Hyperthyroidism; Male; Middle Aged;

2020
Cognitive dysfunction associated with activation of the mTOR signaling pathway after TSH suppression therapy in rats.
    Endocrine journal, 2020, Oct-28, Volume: 67, Issue:10

    Topics: Animals; CA1 Region, Hippocampal; Cognition; Cognitive Dysfunction; Dose-Response Relationship, Drug

2020
Hypothyroidism Induces Interleukin-1-Dependent Autophagy Mechanism as a Key Mediator of Hippocampal Neuronal Apoptosis and Cognitive Decline in Postnatal Rats.
    Molecular neurobiology, 2021, Volume: 58, Issue:3

    Topics: Animals; Animals, Newborn; Apoptosis; Autophagy; Cognitive Dysfunction; Hippocampus; Hypothyroidism;

2021
Subtle Thyroid Dysfunction Is Not Associated with Cognitive Decline: Results from the ELSA-Brasil.
    Journal of Alzheimer's disease : JAD, 2021, Volume: 81, Issue:4

    Topics: Aged; Brazil; Cognition; Cognitive Dysfunction; Comorbidity; Female; Follow-Up Studies; Humans; Male

2021
Cognitive Performance and the Alteration of Neuroendocrine Hormones in Chronic Tension-Type Headache.
    Pain practice : the official journal of World Institute of Pain, 2018, Volume: 18, Issue:1

    Topics: Adrenocorticotropic Hormone; Adult; Case-Control Studies; Chronic Disease; Cognition; Cognitive Dysf

2018
Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of Alzheimer's disease.
    Psychoneuroendocrinology, 2019, Volume: 99

    Topics: Aged; Alzheimer Disease; Cognitive Dysfunction; Dementia; Dementia, Vascular; Female; Follow-Up Stud

2019
Effect of Hormone Levels and Aging on Cognitive Function of Patients with Pituitary Adenomas Prior to Medical Treatment.
    World neurosurgery, 2019, Volume: 128

    Topics: Adenoma; Adolescent; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Case-Control Studies; Co

2019
Naming difficulties after thyroid stimulating hormone suppression therapy in patients with differentiated thyroid carcinoma: a prospective cohort study.
    Endocrine, 2019, Volume: 65, Issue:2

    Topics: Adult; Anomia; Carcinoma; Cognitive Dysfunction; Female; Hormone Replacement Therapy; Humans; Male;

2019
Thyroid status and cognitive function in euthyroid patients with early Parkinson's disease.
    Dementia and geriatric cognitive disorders, 2014, Volume: 38, Issue:3-4

    Topics: Aged; Cognition; Cognitive Dysfunction; Executive Function; Female; Humans; Male; Middle Aged; Neuro

2014
Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment.
    Genetics and molecular research : GMR, 2015, May-22, Volume: 14, Issue:2

    Topics: Adult; Cognitive Dysfunction; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; H

2015
Thyroid hormone disruption and cognitive impairment in rats exposed to PBDE during postnatal development.
    Reproductive toxicology (Elmsford, N.Y.), 2016, Volume: 63

    Topics: Animals; Animals, Newborn; Brain; Cognitive Dysfunction; Cytochrome P-450 CYP1A1; Cytochrome P-450 C

2016
Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a.
    Age (Dordrecht, Netherlands), 2016, Volume: 38, Issue:5-6

    Topics: Acetylation; Aging; Animals; Behavior Rating Scale; Benzhydryl Compounds; Cognitive Dysfunction; Dis

2016
Cognitive Function, APOE Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland.
    Dementia and geriatric cognitive disorders, 2016, Volume: 42, Issue:3-4

    Topics: Alleles; Apolipoprotein E4; Apolipoproteins E; Autoantibodies; Cognition; Cognitive Dysfunction; Fem

2016
Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease.
    Psychoneuroendocrinology, 2013, Volume: 38, Issue:7

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Female; Humans; Male; Neuropsycho

2013