thyroxine has been researched along with Cognition Disorders in 70 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Elevated concentrations of C-reactive protein (CRP) and decreased concentrations of triiodothyronine (T3) were shown to predict poor outcomes in patients with stroke." | 7.80 | Ischemic stroke functional outcomes are independently associated with C-reactive protein concentrations and cognitive outcomes with triiodothyronine concentrations: a pilot study. ( Bunevicius, A; Bunevicius, R; Janusonis, V; Kazlauskas, H; Raskauskiene, N, 2014) |
| "Low free thyroxine levels (<5th percentile) and self-reported prepregnancy thyroid disorder without medical treatment were associated with a decrease of mental scores (Beta = -3." | 7.79 | Thyroxine levels during pregnancy in healthy women and early child neurodevelopment. ( Alvarez-Pedrerol, M; Espada, M; Forns, J; Garcia-Esteban, R; Julvez, J; Lertxundi, N; Murcia, M; Rebagliato, M; Riaño Galán, I; Sunyer, J; Tardón, A, 2013) |
| "To describe intellectual, motor, and school-associated outcome in young adults with early treated congenital hypothyroidism (CH) and to study the association between long-term outcome and CH variables acting at different points in time during early development (CH severity and early L-thyroxine treatment levels [0-6 years])." | 7.72 | Congenital hypothyroidism: influence of disease severity and L-thyroxine treatment on intellectual, motor, and school-associated outcomes in young adults. ( Heyerdahl, S; Kase, BF; Oerbeck, B; Sundet, K, 2003) |
| "Patients previously treated with desiccated thyroid extract (DTE), when being switched to levothyroxine (L-T₄), occasionally did not feel as well despite adequate dosing based on serum TSH levels." | 6.78 | Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. ( Clyde, PW; Hoang, TD; Mai, VQ; Olsen, CH; Shakir, MK, 2013) |
| "T4 or placebo was given at an initial dosage of one tablet of either placebo or 25 microg T4 per day for 12 months." | 6.75 | A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study. ( Franklyn, J; Haque, MS; Heath, C; Hobbs, FD; Parle, J; Pattison, H; Roalfe, A; Roberts, L; Sheppard, M; Wilson, S, 2010) |
| "Hypothyroidism has a variety of adverse effects on cognitive function." | 5.39 | Levothyroxine replacement therapy with vitamin E supplementation prevents oxidative stress and cognitive deficit in experimental hypothyroidism. ( Pan, T; Zhang, Y; Zhong, M; Zhong, X; Zhu, D, 2013) |
| "Hypothyroidism is associated with neurocognitive impairment." | 5.33 | Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. ( Appelhof, BC; Fliers, E; Huyser, J; Schene, AH; Tijssen, JG; Wekking, EM; Wiersinga, WM, 2005) |
| "The role of thyroid function in Alzheimer's disease (AD) has been subject to a number of studies during the last years." | 5.33 | Free thyroxine, cognitive decline and depression in Alzheimer's disease. ( Arlt, S; Mueller-Thomsen, T; Stuerenburg, HJ, 2006) |
| "While clinical hypothyroidism is associated with frank neuropsychological and affective alterations and is considered one of the causes of reversible dementia, the occurrence of these alterations and their treatment in mild hypothyroidism (MH) remains a controversial issue." | 5.32 | Cognitive and affective status in mild hypothyroidism and interactions with L-thyroxine treatment. ( Blandini, F; Bono, G; Fancellu, R; Mauri, M; Santoro, G, 2004) |
| "Subclinical hyperthyroidism is defined by low or undetectable serum thyroid-stimulating hormone levels, with normal free thyroxine and total or free triiodothyronine levels." | 4.87 | Update on subclinical hyperthyroidism. ( Braunstein, GD; Donangelo, I, 2011) |
| "Elevated concentrations of C-reactive protein (CRP) and decreased concentrations of triiodothyronine (T3) were shown to predict poor outcomes in patients with stroke." | 3.80 | Ischemic stroke functional outcomes are independently associated with C-reactive protein concentrations and cognitive outcomes with triiodothyronine concentrations: a pilot study. ( Bunevicius, A; Bunevicius, R; Janusonis, V; Kazlauskas, H; Raskauskiene, N, 2014) |
| "Low free thyroxine levels (<5th percentile) and self-reported prepregnancy thyroid disorder without medical treatment were associated with a decrease of mental scores (Beta = -3." | 3.79 | Thyroxine levels during pregnancy in healthy women and early child neurodevelopment. ( Alvarez-Pedrerol, M; Espada, M; Forns, J; Garcia-Esteban, R; Julvez, J; Lertxundi, N; Murcia, M; Rebagliato, M; Riaño Galán, I; Sunyer, J; Tardón, A, 2013) |
| "The relationship between the content of serum hormones (thyrotrophic hormone, thyroxin, dehydroepiandrosterone (DHEA), DHEA sulfate, prolactin) and cognitive impairment at the acute phase of ischemic stroke in the 1(st), 7(th) and 21(st) day was investigated." | 3.79 | [Hormonal markers of cognitive impairment in patients with the first stroke]. ( Gudkova, VV; Kispaeva, TT; Kol'tsova, EA; Ostrovtsev, IV, 2013) |
| "We identified three women who had TSH receptor blocking Ab-induced MH during pregnancy and were treated with L-thyroxine (L-T4), starting at 27 weeks, 5 weeks, and the first month of gestation." | 3.78 | Severe maternal hypothyroidism corrected prior to the third trimester is associated with normal cognitive outcome in the offspring. ( Brown, RS; Carswell, J; Downing, S; Halpern, L, 2012) |
| "After 12 weeks of treatment (before pregnancy), iodine concentrations in urine and thyroid tissue and circulating thyroxine of adult females correlated with iodine intake." | 3.78 | Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring. ( Fan, C; Li, J; Liu, Y; Mao, J; Shan, Z; Teng, W; Wang, H; Zhang, H; Zhang, L, 2012) |
| " Using bromodeoxyuridine (BrdU), we demonstrate that adult-onset hypothyroidism significantly decreases hippocampal neurogenesis." | 3.73 | Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain. ( Agashe, S; Daniel, SM; Desouza, LA; Ladiwala, U; Vaidya, RA; Vaidya, VA, 2005) |
| "To describe intellectual, motor, and school-associated outcome in young adults with early treated congenital hypothyroidism (CH) and to study the association between long-term outcome and CH variables acting at different points in time during early development (CH severity and early L-thyroxine treatment levels [0-6 years])." | 3.72 | Congenital hypothyroidism: influence of disease severity and L-thyroxine treatment on intellectual, motor, and school-associated outcomes in young adults. ( Heyerdahl, S; Kase, BF; Oerbeck, B; Sundet, K, 2003) |
| "Physicians should actively address psychiatric and cognitive aspects of hypothyroidism and in addition to thyroxine offer supportive treatment, especially to those depressed." | 3.71 | [Psychiatric and cognitive aspects of hypothyroidism]. ( Bjerke, SN; Bjøro, T; Heyerdahl, S, 2001) |
| "Patients previously treated with desiccated thyroid extract (DTE), when being switched to levothyroxine (L-T₄), occasionally did not feel as well despite adequate dosing based on serum TSH levels." | 2.78 | Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. ( Clyde, PW; Hoang, TD; Mai, VQ; Olsen, CH; Shakir, MK, 2013) |
| "T4 or placebo was given at an initial dosage of one tablet of either placebo or 25 microg T4 per day for 12 months." | 2.75 | A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study. ( Franklyn, J; Haque, MS; Heath, C; Hobbs, FD; Parle, J; Pattison, H; Roalfe, A; Roberts, L; Sheppard, M; Wilson, S, 2010) |
| "Subclinical hyperthyroidism has been associated with increased risk of atrial fibrillation and osteoporosis, but the association with cardiovascular disease and death is uncertain." | 2.72 | Decision Making in Subclinical Thyroid Disease. ( Evron, JM; Papaleontiou, M, 2021) |
| "These tests were repeated twice before treatment and after hypothyroidism had been cured." | 2.69 | [Is cognitive change related to hypothyroidism reversible with replacement therapy?]. ( Bercoff, E; Capet, C; Chassagne, P; Clerc, I; Cornier, AC; Denis, P; Doucet, J; Jego, A; Lefebvre, H; Lévesque, H; Noel, D, 2000) |
| "Overt hypothyroidism has major effects on neuropsychiatric function, but patients with mild hypothyroidism may attribute unrelated neuropsychiatric symptoms to their thyroid condition." | 2.50 | Psychiatric and cognitive manifestations of hypothyroidism. ( Samuels, MH, 2014) |
| "Hypothyroidism and hyperthyroidism are commonly present conditions in adults, leading to neurological symptoms, affecting the central and peripheral nervous system, and to neurocognitive impairment." | 2.44 | Thyroid function, Alzheimer's disease and postoperative cognitive dysfunction: a tale of dangerous liaisons? ( Fodale, V; Mafrica, F, 2008) |
| "Hypothyroidism impacts aspects of cognitive functioning and mood." | 2.44 | Neuropsychiatric aspects of hypothyroidism and treatment reversibility. . ( Davis, JD; Tremont, G, 2007) |
| "Subclinical hypothyroidism is more common than HO and is most prevalent in the elderly, particularly in women." | 2.42 | Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderly. ( Davis, JD; Flashman, LA; Stern, RA, 2003) |
| "Hypothyroidism has also been considered a classic reversible dementia; however, the aetiological association between dementia and hypothyroidism is by no means indisputable." | 2.41 | [Dementia and hypothyroidism]. ( Fylkesnes, SI; Nygaard, HA, 2000) |
| "His longstanding CH was associated with empty sella syndrome, static encephalopathy, and severe musculoskeletal deformities." | 1.43 | Case Report: The Specter of Untreated Congenital Hypothyroidism in Immigrant Families. ( Drilling, A; Fischer, M; Hamdoun, E; Karachunski, P; Nathan, B; Petryk, A; Torkelson, JL, 2016) |
| "Hypothyroidism has a variety of adverse effects on cognitive function." | 1.39 | Levothyroxine replacement therapy with vitamin E supplementation prevents oxidative stress and cognitive deficit in experimental hypothyroidism. ( Pan, T; Zhang, Y; Zhong, M; Zhong, X; Zhu, D, 2013) |
| "Hypothyroidism is associated with neurocognitive impairment." | 1.33 | Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. ( Appelhof, BC; Fliers, E; Huyser, J; Schene, AH; Tijssen, JG; Wekking, EM; Wiersinga, WM, 2005) |
| "Hypopituitarism is rarely considered in patients who sustain traumatic brain injury and the neuropsychiatric manifestations of posttraumatic hypopituitarism have rarely been reported." | 1.33 | Neuropsychiatric disturbances and hypopituitarism after traumatic brain injury in an elderly man. ( Chang, YC; Tsai, JC; Tseng, FY, 2006) |
| "The role of thyroid function in Alzheimer's disease (AD) has been subject to a number of studies during the last years." | 1.33 | Free thyroxine, cognitive decline and depression in Alzheimer's disease. ( Arlt, S; Mueller-Thomsen, T; Stuerenburg, HJ, 2006) |
| "While clinical hypothyroidism is associated with frank neuropsychological and affective alterations and is considered one of the causes of reversible dementia, the occurrence of these alterations and their treatment in mild hypothyroidism (MH) remains a controversial issue." | 1.32 | Cognitive and affective status in mild hypothyroidism and interactions with L-thyroxine treatment. ( Blandini, F; Bono, G; Fancellu, R; Mauri, M; Santoro, G, 2004) |
| "Plasma ACTH in senile dementia of the Alzheimer's type was lower, but not significant as compared with that in normal controls." | 1.28 | High plasma levels of cortisol in patients with senile dementia of the Alzheimer's type. ( Kumahara, Y; Masugi, F; Morimoto, S; Nishide, M; Ogihara, T; Otsuka, A; Saeki, S; Sakaguchi, K; Tsuchiya, Y, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (7.14) | 18.7374 |
| 1990's | 6 (8.57) | 18.2507 |
| 2000's | 27 (38.57) | 29.6817 |
| 2010's | 30 (42.86) | 24.3611 |
| 2020's | 2 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Evron, JM | 1 |
| Papaleontiou, M | 1 |
| Naafs, JC | 1 |
| Marchal, JP | 1 |
| Fliers, E | 2 |
| Verkerk, PH | 1 |
| Luijten, MAJ | 1 |
| Boelen, A | 1 |
| van Trotsenburg, ASP | 1 |
| Zwaveling-Soonawala, N | 1 |
| Dietlein, M | 1 |
| Drzezga, A | 1 |
| Seyedhosseini Tamijani, SM | 1 |
| Beirami, E | 1 |
| Ahmadiani, A | 1 |
| Dargahi, L | 1 |
| Hoang, TD | 1 |
| Olsen, CH | 1 |
| Mai, VQ | 1 |
| Clyde, PW | 1 |
| Shakir, MK | 1 |
| Wijsman, LW | 1 |
| de Craen, AJ | 3 |
| Trompet, S | 1 |
| Gussekloo, J | 3 |
| Stott, DJ | 1 |
| Rodondi, N | 1 |
| Welsh, P | 1 |
| Jukema, JW | 1 |
| Westendorp, RG | 3 |
| Mooijaart, SP | 1 |
| Watson, LA | 1 |
| Solomon, LA | 1 |
| Li, JR | 1 |
| Jiang, Y | 1 |
| Edwards, M | 1 |
| Shin-ya, K | 1 |
| Beier, F | 1 |
| Bérubé, NG | 1 |
| Bunevicius, A | 1 |
| Kazlauskas, H | 1 |
| Raskauskiene, N | 1 |
| Janusonis, V | 1 |
| Bunevicius, R | 1 |
| Pocsay, G | 1 |
| Gazdag, A | 1 |
| Engelhardt, J | 1 |
| Szaniszló, I | 1 |
| Szolnoki, Z | 1 |
| Forczek, G | 1 |
| Mikló, L | 1 |
| E Silva, SO | 1 |
| Chan, IT | 1 |
| Lobo Santos, MA | 1 |
| Cohen, M | 1 |
| de La Roque P Araujo, M | 1 |
| da Silva Almeida, J | 1 |
| Simões, A | 1 |
| Givigi, HR | 1 |
| Vaisman, M | 1 |
| Paixão, CM | 1 |
| de Fatima Dos S Teixeira, P | 1 |
| Kispaeva, TT | 1 |
| Ostrovtsev, IV | 1 |
| Gudkova, VV | 1 |
| Kol'tsova, EA | 1 |
| Moon, JH | 1 |
| Ahn, S | 1 |
| Seo, J | 1 |
| Han, JW | 1 |
| Kim, KM | 1 |
| Choi, SH | 1 |
| Lim, S | 1 |
| Park, YJ | 1 |
| Park, DJ | 1 |
| Kim, KW | 1 |
| Jang, HC | 1 |
| Samuels, MH | 1 |
| Clairman, H | 1 |
| Skocic, J | 1 |
| Lischinsky, JE | 1 |
| Rovet, J | 1 |
| Dejanović, M | 1 |
| Ivetić, V | 1 |
| Nestorović, V | 1 |
| Milanović, Z | 1 |
| Erić, M | 1 |
| Labad, J | 1 |
| Barbero, JD | 1 |
| Gutiérrez-Zotes, A | 1 |
| Montalvo, I | 1 |
| Creus, M | 1 |
| Cabezas, Á | 1 |
| Solé, M | 1 |
| Algora, MJ | 1 |
| Garcia-Parés, G | 1 |
| Vilella, E | 1 |
| Hamdoun, E | 1 |
| Karachunski, P | 1 |
| Nathan, B | 1 |
| Fischer, M | 1 |
| Torkelson, JL | 1 |
| Drilling, A | 1 |
| Petryk, A | 1 |
| Mafrica, F | 1 |
| Fodale, V | 1 |
| Opazo, MC | 1 |
| Gianini, A | 1 |
| Pancetti, F | 1 |
| Azkcona, G | 1 |
| Alarcón, L | 1 |
| Lizana, R | 1 |
| Noches, V | 1 |
| Gonzalez, PA | 1 |
| Marassi, MP | 1 |
| Porto, M | 1 |
| Mora, S | 1 |
| Rosenthal, D | 1 |
| Eugenin, E | 1 |
| Naranjo, D | 1 |
| Bueno, SM | 1 |
| Kalergis, AM | 1 |
| Riedel, CA | 1 |
| Kramer, CK | 1 |
| von Mühlen, D | 1 |
| Kritz-Silverstein, D | 1 |
| Barrett-Connor, E | 1 |
| Payer, J | 1 |
| Petrovic, T | 1 |
| Baqi, L | 1 |
| Lisy, L | 1 |
| Langer, P | 1 |
| Voll, R | 1 |
| Reverter, JL | 2 |
| Colomé, E | 2 |
| Puig Domingo, M | 1 |
| Julián, T | 1 |
| Halperin, I | 1 |
| Sanmartí, A | 1 |
| Parle, J | 1 |
| Roberts, L | 1 |
| Wilson, S | 2 |
| Pattison, H | 2 |
| Roalfe, A | 2 |
| Haque, MS | 1 |
| Heath, C | 1 |
| Sheppard, M | 1 |
| Franklyn, J | 2 |
| Hobbs, FD | 2 |
| Donangelo, I | 1 |
| Braunstein, GD | 1 |
| Beydoun, MA | 1 |
| Beydoun, HA | 1 |
| Shroff, MR | 1 |
| Kitner-Triolo, MH | 1 |
| Zonderman, AB | 1 |
| Behrooz, HG | 1 |
| Tohidi, M | 1 |
| Mehrabi, Y | 1 |
| Behrooz, EG | 1 |
| Tehranidoost, M | 1 |
| Azizi, F | 1 |
| Jaracz, J | 1 |
| Kucharska, A | 1 |
| Rajewska-Rager, A | 1 |
| Lacka, K | 1 |
| La Gamma, EF | 1 |
| Paneth, N | 1 |
| Joffe, RT | 1 |
| Pearce, EN | 1 |
| Hennessey, JV | 1 |
| Ryan, JJ | 1 |
| Stern, RA | 3 |
| Downing, S | 1 |
| Halpern, L | 1 |
| Carswell, J | 1 |
| Brown, RS | 1 |
| Pan, T | 1 |
| Zhong, M | 1 |
| Zhong, X | 1 |
| Zhang, Y | 1 |
| Zhu, D | 1 |
| Zhang, L | 1 |
| Teng, W | 1 |
| Liu, Y | 1 |
| Li, J | 1 |
| Mao, J | 1 |
| Fan, C | 1 |
| Wang, H | 1 |
| Zhang, H | 1 |
| Shan, Z | 1 |
| Persson, N | 1 |
| Viitanen, M | 1 |
| Almkvist, O | 1 |
| Wahlin, Å | 1 |
| Julvez, J | 2 |
| Alvarez-Pedrerol, M | 2 |
| Rebagliato, M | 1 |
| Murcia, M | 1 |
| Forns, J | 1 |
| Garcia-Esteban, R | 1 |
| Lertxundi, N | 1 |
| Espada, M | 1 |
| Tardón, A | 1 |
| Riaño Galán, I | 1 |
| Sunyer, J | 2 |
| Davis, JD | 3 |
| Flashman, LA | 1 |
| Oerbeck, B | 1 |
| Sundet, K | 1 |
| Kase, BF | 1 |
| Heyerdahl, S | 2 |
| Bono, G | 1 |
| Fancellu, R | 1 |
| Blandini, F | 1 |
| Santoro, G | 1 |
| Mauri, M | 1 |
| Brown, K | 1 |
| Rodgers, J | 1 |
| Johnstone, H | 1 |
| Adams, W | 1 |
| Clarke, M | 1 |
| Gibson, M | 1 |
| Cheetham, T | 1 |
| Krausz, Y | 1 |
| Freedman, N | 1 |
| Lester, H | 1 |
| Newman, JP | 1 |
| Barkai, G | 1 |
| Bocher, M | 1 |
| Chisin, R | 1 |
| Bonne, O | 1 |
| Koppe, JG | 1 |
| van Exel, E | 2 |
| Meinders, AE | 2 |
| Frölich, M | 2 |
| Rogers, BL | 1 |
| Smith, KE | 1 |
| Harrington, CJ | 1 |
| Ott, BR | 1 |
| Jackson, IM | 1 |
| Prange, AJ | 1 |
| Lazarus, JH | 1 |
| Desouza, LA | 1 |
| Ladiwala, U | 1 |
| Daniel, SM | 1 |
| Agashe, S | 1 |
| Vaidya, RA | 1 |
| Vaidya, VA | 1 |
| Wekking, EM | 1 |
| Appelhof, BC | 1 |
| Schene, AH | 1 |
| Huyser, J | 1 |
| Tijssen, JG | 1 |
| Wiersinga, WM | 1 |
| Chang, YC | 1 |
| Tsai, JC | 1 |
| Tseng, FY | 1 |
| Kasatkina, EP | 1 |
| Samsonova, LN | 1 |
| Ivakhnenko, VN | 1 |
| Ibragimova, GV | 1 |
| Ryabykh, AV | 1 |
| Naumenko, LL | 1 |
| Evdokimova, YA | 1 |
| Roberts, LM | 1 |
| Parle, JV | 1 |
| Stuerenburg, HJ | 1 |
| Arlt, S | 1 |
| Mueller-Thomsen, T | 1 |
| Tremont, G | 1 |
| Ribas-Fitó, N | 1 |
| Torrent, M | 1 |
| Ferrer, C | 1 |
| Samson, JA | 1 |
| Mirin, SM | 1 |
| Griffin, M | 1 |
| Borrelli, D | 1 |
| Schildkraut, JJ | 1 |
| Leentjens, AF | 1 |
| Kappers, EJ | 1 |
| Kooistra, L | 1 |
| van der Meere, JJ | 1 |
| Vulsma, T | 1 |
| Kalverboer, AF | 1 |
| Baldini, IM | 1 |
| Vita, A | 1 |
| Mauri, MC | 1 |
| Amodei, V | 1 |
| Carrisi, M | 1 |
| Bravin, S | 1 |
| Cantalamessa, L | 1 |
| Prinz, PN | 1 |
| Scanlan, JM | 1 |
| Vitaliano, PP | 1 |
| Moe, KE | 1 |
| Borson, S | 1 |
| Toivola, B | 1 |
| Merriam, GR | 1 |
| Larsen, LH | 1 |
| Reed, HL | 1 |
| Fylkesnes, SI | 1 |
| Nygaard, HA | 1 |
| Capet, C | 1 |
| Jego, A | 1 |
| Denis, P | 1 |
| Noel, D | 1 |
| Clerc, I | 1 |
| Cornier, AC | 1 |
| Lefebvre, H | 1 |
| Lévesque, H | 1 |
| Chassagne, P | 1 |
| Bercoff, E | 1 |
| Doucet, J | 1 |
| Bjerke, SN | 1 |
| Bjøro, T | 1 |
| Volpato, S | 1 |
| Guralnik, JM | 1 |
| Fried, LP | 1 |
| Remaley, AT | 1 |
| Cappola, AR | 1 |
| Launer, LJ | 1 |
| Judd, LL | 1 |
| Hubbard, B | 1 |
| Janowsky, DS | 1 |
| Huey, LY | 1 |
| Attewell, PA | 1 |
| MacCrimmon, DJ | 1 |
| Wallace, JE | 1 |
| Goldberg, WM | 1 |
| Streiner, DL | 1 |
| Jayaratna, PS | 1 |
| Osterweil, D | 1 |
| Syndulko, K | 1 |
| Cohen, SN | 1 |
| Pettler-Jennings, PD | 1 |
| Hershman, JM | 1 |
| Cummings, JL | 1 |
| Tourtellotte, WW | 1 |
| Solomon, DH | 1 |
| Masugi, F | 1 |
| Ogihara, T | 1 |
| Sakaguchi, K | 1 |
| Otsuka, A | 1 |
| Tsuchiya, Y | 1 |
| Morimoto, S | 1 |
| Kumahara, Y | 1 |
| Saeki, S | 1 |
| Nishide, M | 1 |
| Jain, VK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vitamin D Receptor and Megalin Gene Polymorphisms and Their Association With Obesity, Central Obesity and the Metabolic Syndrome[NCT03279432] | 1,021 participants (Actual) | Observational | 2004-08-18 | Completed | |||
| Bio-psycho-social Correlates of Psychological Distress in Patients With Graves' Disease in Euthyroid Status[NCT02620085] | 500 participants (Anticipated) | Observational | 2011-07-31 | Recruiting | |||
| Transient Hypothyroxinemia of Prematurity: Electrophysiological Changes in the Preterm Infants' Brain, a Retrospective Study[NCT03493113] | 87 participants (Actual) | Observational | 2011-10-31 | Completed | |||
| Evaluation of Thyroid Function in Children With Congenital Heart Disease[NCT03496363] | 50 participants (Anticipated) | Observational | 2018-05-01 | Not yet recruiting | |||
| Cognitive Functions and Mood During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid Carcinoma[NCT02665325] | 100 participants (Anticipated) | Observational | 2016-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for thyroxine and Cognition Disorders
| Article | Year |
|---|---|
Decision Making in Subclinical Thyroid Disease.
Topics: Age Factors; Atrial Fibrillation; Cardiovascular Diseases; Clinical Decision-Making; Cognition Disor | 2021 |
Psychiatric and cognitive manifestations of hypothyroidism.
Topics: Cognition Disorders; Dose-Response Relationship, Drug; Executive Function; Hormone Replacement Thera | 2014 |
Thyroid function, Alzheimer's disease and postoperative cognitive dysfunction: a tale of dangerous liaisons?
Topics: Aged; Alzheimer Disease; Brain; Cholinergic Fibers; Cognition Disorders; Delirium; Euthyroid Sick Sy | 2008 |
Hashimoto's encephalopathy and rare cases of hyperthyroidism (review and case report).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Autoantigens; Brain Diseases; Child; Cog | 2009 |
[Undetected Hashimoto encephalopathy--a diagnostic challenge in child psychiatry and child neurology].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; Brain Damage, Chronic; Child; Cognition | 2010 |
[Potential risks of the adverse effects of thyrotropin suppression in differentiated thyroid carcinoma].
Topics: Adenocarcinoma, Follicular; Aged; Bone Remodeling; Carcinoma, Papillary; Cardiovascular Diseases; Co | 2011 |
Update on subclinical hyperthyroidism.
Topics: Adult; Age Factors; Aged; Atrial Fibrillation; Bone Density; Cognition; Cognition Disorders; Evidenc | 2011 |
Clinical importance of hypothyroxinemia in the preterm infant and a discussion of treatment concerns.
Topics: Cerebral Palsy; Cognition Disorders; Developmental Disabilities; Hormone Replacement Therapy; Humans | 2012 |
Subclinical hypothyroidism, mood, and cognition in older adults: a review.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Consensus; Hormone Replacement Therapy; Humans; Hypoth | 2013 |
Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderly.
Topics: Aged; Clinical Trials as Topic; Cognition Disorders; Dementia; Depressive Disorder; Humans; Hypothal | 2003 |
Neuropsychiatric aspects of hypothyroidism and treatment reversibility. .
Topics: Adult; Age Factors; Aged; Animals; Autoantibodies; Brain; Cerebrovascular Circulation; Cognition Dis | 2007 |
[Dementia and hypothyroidism].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Diagnosis, Differential | 2000 |
6 trials available for thyroxine and Cognition Disorders
| Article | Year |
|---|---|
Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study.
Topics: Adult; Aged; Animals; Cognition; Cognition Disorders; Cross-Over Studies; Dietary Supplements; Doubl | 2013 |
A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study.
Topics: Aged; Aged, 80 and over; Cognition; Cognition Disorders; Cross-Sectional Studies; Double-Blind Metho | 2010 |
Regional cerebral blood flow in patients with mild hypothyroidism.
Topics: Adult; Brain; Cerebrovascular Circulation; Cognition Disorders; Female; Humans; Hypothyroidism; Midd | 2004 |
Preliminary study of the relationship between thyroid status and cognitive and neuropsychiatric functioning in euthyroid patients with Alzheimer dementia.
Topics: Affective Symptoms; Aged; Alzheimer Disease; Cognition Disorders; Cross-Sectional Studies; Donepezil | 2004 |
[Is cognitive change related to hypothyroidism reversible with replacement therapy?].
Topics: Age Factors; Aged; Attention; Cognition Disorders; Female; Hormone Replacement Therapy; Humans; Hypo | 2000 |
The effect of lithium carbonate on affect, mood, and personality of normal subjects.
Topics: Adult; Affect; Anxiety; Clinical Trials as Topic; Cognition Disorders; Confusion; Emotions; Fatigue; | 1977 |
52 other studies available for thyroxine and Cognition Disorders
| Article | Year |
|---|---|
Cognitive and Motor Outcome in Patients with Early-Detected Central Congenital Hypothyroidism Compared with Siblings.
Topics: Adolescent; Child; Child, Preschool; Cognition; Cognition Disorders; Congenital Hypothyroidism; Cros | 2021 |
Topics: Atherosclerosis; Cognition Disorders; Drug Utilization; Heart Diseases; Humans; Hypothyroidism; Rena | 2018 |
Thyroid hormone treatment alleviates the impairments of neurogenesis, mitochondrial biogenesis and memory performance induced by methamphetamine.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cognition; Cognition Disorders; Double | 2019 |
Subclinical thyroid dysfunction and cognitive decline in old age.
Topics: Aged; Aged, 80 and over; Aging; Cognition Disorders; Female; Humans; Hyperthyroidism; Hypothyroidism | 2013 |
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.
Topics: Aging; Animals; Bone and Bones; Brain; Cognition Disorders; DNA Damage; DNA Helicases; Female; Fibro | 2013 |
Ischemic stroke functional outcomes are independently associated with C-reactive protein concentrations and cognitive outcomes with triiodothyronine concentrations: a pilot study.
Topics: Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Cognition Disorders; Female; Humans; Male; | 2014 |
[Hashimoto encephalopathy].
Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; Antipsychotic Agents; Autoantibodies; Brain Disease | 2013 |
Impact of thyroid status and age on comprehensive geriatric assessment.
Topics: Activities of Daily Living; Age Factors; Aged; Aged, 80 and over; Aging; Cognition; Cognition Disord | 2014 |
[Hormonal markers of cognitive impairment in patients with the first stroke].
Topics: Aged; Biomarkers; Cognition Disorders; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Femal | 2013 |
The effect of long-term thyroid-stimulating hormone suppressive therapy on the cognitive function of elderly patients with differentiated thyroid carcinoma.
Topics: Aged; Aging; Case-Control Studies; Cell Differentiation; Cognition Disorders; Cross-Sectional Studie | 2014 |
Do children with congenital hypothyroidism exhibit abnormal cortical morphology?
Topics: Adolescent; Behavior; Cerebral Cortex; Child; Cognition Disorders; Congenital Hypothyroidism; Female | 2015 |
The value of P300 event related potentials in the assessment of cognitive function in subclinical hypothyroidism.
Topics: Adult; Cognition Disorders; Event-Related Potentials, P300; Evoked Potentials, Auditory; Female; Hum | 2017 |
Free thyroxine levels are associated with cognitive changes in individuals with a first episode of psychosis: A prospective 1-year follow-up study.
Topics: Adolescent; Adult; Analysis of Variance; Cognition Disorders; Female; Follow-Up Studies; Humans; Mal | 2016 |
Case Report: The Specter of Untreated Congenital Hypothyroidism in Immigrant Families.
Topics: Adolescent; Brain Diseases; Child; Cognition Disorders; Congenital Hypothyroidism; Delayed Diagnosis | 2016 |
Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring.
Topics: Age Factors; Animals; Cognition Disorders; Disks Large Homolog 4 Protein; Female; Hypothyroidism; Im | 2008 |
Treated hypothyroidism, cognitive function, and depressed mood in old age: the Rancho Bernardo Study.
Topics: Aged; Cognition; Cognition Disorders; Depression; Female; Humans; Hypothyroidism; Male; Middle Aged; | 2009 |
[Clinical endocrinologists' perception of the deleterious effects of TSH suppressive therapy in patients with differentiated thyroid carcinoma].
Topics: Adult; Attitude of Health Personnel; Carcinoma; Cognition Disorders; Cross-Sectional Studies; Data C | 2010 |
Serum leptin, thyroxine and thyroid-stimulating hormone levels interact to affect cognitive function among US adults: evidence from a large representative survey.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Aging; Biomarkers; Cognition; Cognition Disorders; | 2012 |
Subclinical hypothyroidism in pregnancy: intellectual development of offspring.
Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Cognition Disorders; Female; Human | 2011 |
Cognitive functions and mood during chronic thyrotropin-suppressive therapy with L-thyroxine in patients with differentiated thyroid carcinoma.
Topics: Adenocarcinoma; Adult; Cell Differentiation; Cognition Disorders; Depression; Female; Humans; Hypert | 2012 |
Severe maternal hypothyroidism corrected prior to the third trimester is associated with normal cognitive outcome in the offspring.
Topics: Child; Child Welfare; Child, Preschool; Cognition; Cognition Disorders; Female; Humans; Hypothyroidi | 2012 |
Levothyroxine replacement therapy with vitamin E supplementation prevents oxidative stress and cognitive deficit in experimental hypothyroidism.
Topics: Animals; Cognition Disorders; Dietary Supplements; Disease Models, Animal; Hippocampus; Hormone Repl | 2013 |
Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring.
Topics: Age Factors; Animals; Animals, Newborn; Anti-Infective Agents, Local; Brain-Derived Neurotrophic Fac | 2012 |
A principal component model of medical health: implications for cognitive deficits and decline among adults in a population-based sample.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Blood Glucose; Cholesterol; Cognition; Cognition | 2013 |
Thyroxine levels during pregnancy in healthy women and early child neurodevelopment.
Topics: Adolescent; Adult; Biomarkers; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Congenital hypothyroidism: influence of disease severity and L-thyroxine treatment on intellectual, motor, and school-associated outcomes in young adults.
Topics: Adult; Cognition Disorders; Congenital Hypothyroidism; Educational Measurement; Female; Humans; Hypo | 2003 |
Cognitive and affective status in mild hypothyroidism and interactions with L-thyroxine treatment.
Topics: Adult; Age Factors; Aged; Attention; Cognition Disorders; Depressive Disorder; Female; Homeostasis; | 2004 |
Abnormal cognitive function in treated congenital hypopituitarism.
Topics: Adolescent; Child; Cognition Disorders; Cross-Sectional Studies; Female; Hormone Replacement Therapy | 2004 |
Are maternal thyroid autoantibodies generated by PCBs the missing link to impaired development of the brain?
Topics: Adult; Antibody Formation; Autoantibodies; Brain; Cognition Disorders; Environmental Pollutants; Fem | 2004 |
Thyroid status, disability and cognitive function, and survival in old age.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Cognition Disorders; Depression; Disabled Perso | 2004 |
Congenital hypothyroidism.
Topics: Brain; Child; Cognition Disorders; Congenital Hypothyroidism; Drug Administration Schedule; Humans; | 2005 |
Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain.
Topics: Aging; Animals; Bromodeoxyuridine; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, C | 2005 |
Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism.
Topics: Adult; Aged; Antibodies; Attention; Autoimmune Diseases; Cognition; Cognition Disorders; Female; Hor | 2005 |
[Thyroid function, activities of daily living and survival in extreme old age: the 'Leiden 85-plus Study'].
Topics: Activities of Daily Living; Aged, 80 and over; Cognition Disorders; Depression; Disabled Persons; Fe | 2006 |
Neuropsychiatric disturbances and hypopituitarism after traumatic brain injury in an elderly man.
Topics: Aged; Brain Injuries; Cognition Disorders; Hormone Replacement Therapy; Humans; Hypopituitarism; Mal | 2006 |
Gestational hypothyroxinemia and cognitive function in offspring.
Topics: Child Development; Cognition; Cognition Disorders; Female; Humans; Hypothyroidism; Infant; Infant, N | 2006 |
Summaries for patients. Mild thyroid dysfunction is not associated with anxiety, depression, or cognition in the elderly.
Topics: Aged; Aged, 80 and over; Anxiety Disorders; Cognition Disorders; Cross-Sectional Studies; Depressive | 2006 |
Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction?
Topics: Aged; Aged, 80 and over; Anxiety Disorders; Cognition Disorders; Cross-Sectional Studies; Depressive | 2006 |
Free thyroxine, cognitive decline and depression in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Depression; Female; Humans; Hypothy | 2006 |
TSH concentration within the normal range is associated with cognitive function and ADHD symptoms in healthy preschoolers.
Topics: Attention Deficit Disorder with Hyperactivity; Child, Preschool; Cognition Disorders; Cross-Sectiona | 2007 |
Urinary MHPG and clinical symptoms in patients with unipolar depression.
Topics: Adult; Body Weight; Cognition Disorders; Depressive Disorder; Dexamethasone; Female; Humans; Hydroco | 1994 |
Persistent cognitive defects after corrected hypothyroidism.
Topics: Adult; Attention; Brain Damage, Chronic; Cognition Disorders; Female; Follow-Up Studies; Humans; Hyp | 1995 |
Sustained attention problems in children with early treated congenital hypothyroidism.
Topics: Attention; Case-Control Studies; Child; Cognition Disorders; Congenital Hypothyroidism; Diagnosis, C | 1996 |
Psychopathological and cognitive features in subclinical hypothyroidism.
Topics: Adult; Aged; Anxiety; Brief Psychiatric Rating Scale; Cognition Disorders; Depression; Female; Goite | 1997 |
Thyroid hormones: positive relationships with cognition in healthy, euthyroid older men.
Topics: Aged; Aging; Cognition; Cognition Disorders; Dementia; Educational Status; Humans; Hypothyroidism; I | 1999 |
[Psychiatric and cognitive aspects of hypothyroidism].
Topics: Adult; Anxiety Disorders; Cognition Disorders; Depression; Female; Humans; Hypothyroidism; Male; Men | 2001 |
Serum thyroxine level and cognitive decline in euthyroid older women.
Topics: Aged; Aging; Analysis of Variance; Chi-Square Distribution; Cognition Disorders; Cross-Sectional Stu | 2002 |
Emotional disturbance and cognitive deficits in hyperthyroidism.
Topics: Age Factors; Cognition Disorders; Electroencephalography; Female; Humans; Hyperthyroidism; Mental Di | 1979 |
Hypothyroidism with episodic psychiatric and cardiac manifestations.
Topics: Cognition Disorders; Confusion; Electrocardiography; Electroencephalography; Female; Heart Diseases; | 1976 |
Cognitive function in non-demented older adults with hypothyroidism.
Topics: Adult; Aged; Aged, 80 and over; Cognition Disorders; Electrophysiology; Evaluation Studies as Topic; | 1992 |
High plasma levels of cortisol in patients with senile dementia of the Alzheimer's type.
Topics: Adrenocorticotropic Hormone; Aged; Alzheimer Disease; Blood Pressure; Cognition Disorders; Humans; H | 1989 |
A psychiatric study of hypothyroidism.
Topics: Adult; Affective Symptoms; Aged; Anxiety Disorders; Cognition Disorders; Delusions; Depression; Fema | 1972 |