Page last updated: 2024-11-06

thyroxine and Chronic Kidney Diseases

thyroxine has been researched along with Chronic Kidney Diseases in 29 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"Chronic kidney disease (CKD) may be associated with overt or subclinical hypothyroidism [SCH; defined as elevated serum thyroid-stimulating hormone (TSH) despite normal free thyroxine levels)."8.02Effect of Levothyroxine on Kidney Function in Chronic Kidney Disease with Subclinical Hypothyroidism in US Veterans: A Retrospective Observational Cohort Study. ( Duan, Y; Gossain, VV; Hennessey, JV; Soni-Brahmbhatt, S; Weir, MR, 2021)
"To determine the relationship between serum SDMA, creatinine and total thyroxine (TT4) concentrations in hyperthyroid cats before (T0) and 3 months after (T1) receiving a PO fixed dose of radioiodine."7.96Assessment of serum symmetric dimethylarginine and creatinine concentrations in hyperthyroid cats before and after a fixed dose of orally administered radioiodine. ( Finch, S; Johnstone, T; Lacorcia, L; Yu, L, 2020)
"Chronic kidney disease (CKD) may be associated with overt or subclinical hypothyroidism [SCH; defined as elevated serum thyroid-stimulating hormone (TSH) despite normal free thyroxine levels)."4.02Effect of Levothyroxine on Kidney Function in Chronic Kidney Disease with Subclinical Hypothyroidism in US Veterans: A Retrospective Observational Cohort Study. ( Duan, Y; Gossain, VV; Hennessey, JV; Soni-Brahmbhatt, S; Weir, MR, 2021)
"To determine the relationship between serum SDMA, creatinine and total thyroxine (TT4) concentrations in hyperthyroid cats before (T0) and 3 months after (T1) receiving a PO fixed dose of radioiodine."3.96Assessment of serum symmetric dimethylarginine and creatinine concentrations in hyperthyroid cats before and after a fixed dose of orally administered radioiodine. ( Finch, S; Johnstone, T; Lacorcia, L; Yu, L, 2020)
"Concentrations of thyroid stimulating hormone (TSH), free thyroxine (FT4), triiodothyronine (T3) and thyroid peroxidase antibody (TPOAb) were quantified in 12 785 black and white participants of the ongoing community-based prospective Atherosclerosis Risk in Communities study."3.85Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study. ( Coresh, J; Daya, N; Grams, ME; Köttgen, A; Schultheiss, UT; Selvin, E; Seufert, J; Steffes, M, 2017)
" Serum concentrations of creatinine, urea, electrolytes and total proteins and albumin were measured as well."3.81Evaluation of thyroid hormone levels in chronic kidney disease patients. ( Chickballapur Rayappa, WD; Kumar, S; Rajeev, G; Swathi, M; Vijayalakshmi, R, 2015)
"We report the case of a young woman affected by hypothyroidism due to Hashimoto's thyroiditis, previously well compensated with a full replacement therapy (150 mcg/day of levothyroxine), presenting a clinical picture of myxedema, with a TSH=650 mU/L."3.80Sevelamer carbonate markedly reduces levothyroxine absorption. ( Giagulli, VA; Guastamacchia, E; Iovine, N; Iovino, M; Licchelli, B; Petrosino, A; Triggiani, V, 2014)
"Iatrogenic hypothyroidism is a recognised complication of all of the treatment options for hyperthyroidism, and increases the risk of azotaemia."2.82Feline Comorbidities: Balancing hyperthyroidism and concurrent chronic kidney disease. ( Aguiar, J; Geddes, R, 2022)
"Oral sodium bicarbonate has been shown to improve nutritional status and preserve renal function in CKD."2.75Oral sodium bicarbonate improves thyroid function in predialysis chronic kidney disease. ( Disthabanchong, S; Treeruttanawanich, A, 2010)
"Subclinical hypothyroidism is an independent predictor of CKD in the general population."1.91Subclinical thyroid dysfunction and chronic kidney disease: a nationwide population-based study. ( Byun, DW; Kim, HJ; Park, HK; Park, SJ; Suh, K; Yoo, MH, 2023)
"Hypothyroidism is associated with reversible decline in kidney function as measured by estimated glomerular filtration rate (eGFR)."1.62Proteinuria in Severe Hypothyroidism: A Prospective Study. ( Chandrasekaran, A; Gondil, VS; Gupta, KL; Jha, V; Kohli, HS; Kumar, V; Ramachandran, R; Rastogi, A; Rathi, M; Sood, A; Yadav, AK, 2021)
"Feline hyperthyroidism is commonly diagnosed in general practice."1.40Medical management and monitoring of the hyperthyroid cat: a survey of UK general practitioners. ( Hibbert, A; Higgs, P; Murray, JK, 2014)
"RAAS activation in hyperthyroidism is associated with increased VEGFCR; however, increased VEGFCR was not correlated with the development of aCKD."1.40Association between urinary vascular endothelial growth factor excretion and chronic kidney disease in hyperthyroid cats. ( Elliott, J; Syme, HM; Williams, TL, 2014)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's18 (62.07)24.3611
2020's11 (37.93)2.80

Authors

AuthorsStudies
Geddes, R1
Aguiar, J1
Zhang, L1
Wu, Y1
Nie, Y1
Lv, W1
Li, Y1
Zhu, B1
Jin, S1
Shen, Z2
Li, F1
Liu, H1
Fang, Y1
Ding, X1
Li, S1
Zeng, M1
Kim, HJ1
Park, SJ1
Park, HK1
Byun, DW1
Suh, K1
Yoo, MH1
Shreewastav, RK1
Ghosh, AK1
Yadav, R1
Katuwal, A1
Shrestha, S1
Yu, L1
Lacorcia, L1
Finch, S1
Johnstone, T1
Li, J1
Wu, X1
Luo, M1
Yan, M1
Wang, Q1
Li, P1
Niu, W1
Gondil, VS1
Chandrasekaran, A1
Rastogi, A1
Yadav, AK1
Sood, A1
Ramachandran, R1
Kumar, V1
Rathi, M1
Kohli, HS1
Jha, V1
Gupta, KL1
Hennessey, JV1
Weir, MR1
Soni-Brahmbhatt, S1
Duan, Y1
Gossain, VV1
Reinhardt, W2
Mülling, N1
Behrendt, S2
Benson, S2
Dolff, S2
Führer, D2
Tan, S1
Kitzmann, S1
Hartmann, K1
Zablotski, Y1
Rieger, A1
Mueller, R1
Wehner, A1
Singh, S1
Verma, A1
Aryal, G1
Thapa, S1
Khakurel, S1
Shrestha, K1
Wang, K1
Xie, K1
Gu, L1
Xu, B1
Chen, J1
Lou, Q1
Yu, Y1
Shan, S1
Wu, D1
Dai, L1
Hu, C1
Tang, W1
Aryee, NA1
Tagoe, EA1
Anomah, V1
Arko-Boham, B1
Adjei, DN1
Dietlein, M1
Drzezga, A1
Gopinath, B1
Harris, DC1
Wall, JR1
Kifley, A1
Mitchell, P1
Higgs, P1
Murray, JK1
Hibbert, A1
Williams, TL1
Elliott, J1
Syme, HM1
Zhang, Y1
Chang, Y1
Ryu, S1
Cho, J1
Lee, WY1
Rhee, EJ1
Kwon, MJ1
Pastor-Barriuso, R1
Rampal, S1
Han, WK1
Shin, H1
Guallar, E1
Iovino, M1
Iovine, N1
Petrosino, A1
Giagulli, VA1
Licchelli, B1
Guastamacchia, E1
Triggiani, V1
Rajeev, G1
Chickballapur Rayappa, WD1
Vijayalakshmi, R1
Swathi, M1
Kumar, S1
van Tienhoven-Wind, LJ1
Dullaart, RP1
Broecker-Preuß, M1
Hög, A1
Schomburg, L1
Köhrle, J1
Al-Mendalawi, MD1
Schultheiss, UT1
Daya, N1
Grams, ME1
Seufert, J1
Steffes, M1
Coresh, J1
Selvin, E1
Köttgen, A1
Du, X1
Pan, B1
Li, W1
Zou, Y1
Hua, X1
Huang, W1
Wan, X1
Cao, C1
Disthabanchong, S1
Treeruttanawanich, A1
Hataya, Y1
Igarashi, S1
Yamashita, T1
Komatsu, Y1
Shin, DH1
Lee, MJ1
Lee, HS1
Oh, HJ1
Ko, KI1
Kim, CH1
Doh, FM1
Koo, HM1
Kim, HR1
Han, JH1
Park, JT1
Han, SH1
Yoo, TH1
Kang, SW1

Reviews

2 reviews available for thyroxine and Chronic Kidney Diseases

ArticleYear
Feline Comorbidities: Balancing hyperthyroidism and concurrent chronic kidney disease.
    Journal of feline medicine and surgery, 2022, Volume: 24, Issue:7

    Topics: Animals; Cat Diseases; Cats; Glomerular Filtration Rate; Hyperthyroidism; Hypothyroidism; Renal Insu

2022
Low-normal thyroid function and the pathogenesis of common cardio-metabolic disorders.
    European journal of clinical investigation, 2015, Volume: 45, Issue:5

    Topics: Asymptomatic Diseases; Cardiovascular Diseases; Cholesterol, LDL; Humans; Hypothyroidism; Insulin Re

2015

Trials

1 trial available for thyroxine and Chronic Kidney Diseases

ArticleYear
Oral sodium bicarbonate improves thyroid function in predialysis chronic kidney disease.
    American journal of nephrology, 2010, Volume: 32, Issue:6

    Topics: Acidosis; Adult; Aged; Aged, 80 and over; Bicarbonates; Female; Humans; Male; Middle Aged; Prospecti

2010

Other Studies

26 other studies available for thyroxine and Chronic Kidney Diseases

ArticleYear
The serum free triiodothyronine to free thyroxine ratio as a potential prognostic biomarker of chronic kidney disease in patients with glomerular crescents: A retrospective study.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Albumins; Biomarkers; Creatinine; Humans; Immunosuppressive Agents; Natriuretic Peptide, Brain; Prog

2022
J-shaped association of free triiodothyronine to free thyroxine ratio with 5-year mortality among patients with chronic kidney disease: a prospective cohort study.
    International urology and nephrology, 2023, Volume: 55, Issue:10

    Topics: Cardiovascular Diseases; Humans; Nutrition Surveys; Prospective Studies; Renal Insufficiency, Chroni

2023
Subclinical thyroid dysfunction and chronic kidney disease: a nationwide population-based study.
    BMC nephrology, 2023, 03-22, Volume: 24, Issue:1

    Topics: Cross-Sectional Studies; Humans; Hypothyroidism; Renal Insufficiency, Chronic; Thyroid Gland; Thyrox

2023
Subclinical Hypothyroidism among Chronic Kidney Disease Patients Admitted to Nephrology Department of a Tertiary Care Centre: A Descriptive Cross-sectional Study.
    JNMA; journal of the Nepal Medical Association, 2023, Apr-01, Volume: 61, Issue:260

    Topics: Cross-Sectional Studies; Humans; Hypothyroidism; Nephrology; Quality of Life; Renal Insufficiency, C

2023
Assessment of serum symmetric dimethylarginine and creatinine concentrations in hyperthyroid cats before and after a fixed dose of orally administered radioiodine.
    Journal of veterinary internal medicine, 2020, Volume: 34, Issue:4

    Topics: Administration, Oral; Animals; Arginine; Cat Diseases; Cats; Cohort Studies; Creatinine; Hyperthyroi

2020
Association of Serum Thyroid Hormones with the Risk and Severity of Chronic Kidney Disease Among 3563 Chinese Adults.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, Jun-22, Volume: 26

    Topics: Adult; Asian People; Biomarkers; China; Creatinine; Female; Humans; Male; Middle Aged; Renal Insuffi

2020
Proteinuria in Severe Hypothyroidism: A Prospective Study.
    The Journal of clinical endocrinology and metabolism, 2021, 01-23, Volume: 106, Issue:2

    Topics: Adult; Cohort Studies; Cross-Sectional Studies; Female; Follow-Up Studies; Glomerular Filtration Rat

2021
Effect of Levothyroxine on Kidney Function in Chronic Kidney Disease with Subclinical Hypothyroidism in US Veterans: A Retrospective Observational Cohort Study.
    Advances in therapy, 2021, Volume: 38, Issue:2

    Topics: Aged; Cohort Studies; Humans; Hypothyroidism; Kidney; Male; Renal Insufficiency, Chronic; Retrospect

2021
Association between albuminuria and thyroid function in patients with chronic kidney disease.
    Endocrine, 2021, Volume: 73, Issue:2

    Topics: Aged; Aged, 80 and over; Albuminuria; Humans; Middle Aged; Renal Insufficiency, Chronic; Thyroid Gla

2021
Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.
    PloS one, 2021, Volume: 16, Issue:8

    Topics: Animals; Body Size; Case-Control Studies; Dog Diseases; Dogs; Dwarfism, Pituitary; Female; Growth Ho

2021
Thyroid hormone profile in patients with chronic kidney disease: a single centre study.
    Journal of Nepal Health Research Council, 2016, Volume: 14, Issue:34

    Topics: Adult; Age Factors; Creatinine; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nepal; R

2016
Association of Thyroid Function With the Estimated Glomerular Filtration Rate in a Large Chinese Euthyroid Population.
    Kidney & blood pressure research, 2018, Volume: 43, Issue:4

    Topics: Adult; Aged; Asian People; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Inci

2018
Thyroid hormone status in Ghanaian patients with chronic kidney disease.
    The Pan African medical journal, 2018, Volume: 29

    Topics: Adult; Aged; Case-Control Studies; Creatinine; Female; Ghana; Glomerular Filtration Rate; Humans; In

2018
    Nuklearmedizin. Nuclear medicine, 2018, Volume: 57, Issue:5

    Topics: Atherosclerosis; Cognition Disorders; Drug Utilization; Heart Diseases; Humans; Hypothyroidism; Rena

2018
Relationship between thyroid dysfunction and chronic kidney disease in community-dwelling older adults.
    Maturitas, 2013, Volume: 75, Issue:2

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hypert

2013
Medical management and monitoring of the hyperthyroid cat: a survey of UK general practitioners.
    Journal of feline medicine and surgery, 2014, Volume: 16, Issue:10

    Topics: Animals; Antithyroid Agents; Cat Diseases; Cats; Disease Management; Hyperthyroidism; Iodine Radiois

2014
Association between urinary vascular endothelial growth factor excretion and chronic kidney disease in hyperthyroid cats.
    Research in veterinary science, 2014, Volume: 96, Issue:3

    Topics: Animals; Cat Diseases; Cats; Creatinine; Female; Hyperthyroidism; Male; Renal Insufficiency, Chronic

2014
Thyroid hormone levels and incident chronic kidney disease in euthyroid individuals: the Kangbuk Samsung Health Study.
    International journal of epidemiology, 2014, Volume: 43, Issue:5

    Topics: Adult; Aged; Creatinine; Female; Follow-Up Studies; Glomerular Filtration Rate; Goiter, Nodular; Hum

2014
Sevelamer carbonate markedly reduces levothyroxine absorption.
    Endocrine, metabolic & immune disorders drug targets, 2014, Volume: 14, Issue:3

    Topics: Adult; Drug Administration Schedule; Drug Interactions; Female; Hashimoto Disease; Humans; Intestina

2014
Evaluation of thyroid hormone levels in chronic kidney disease patients.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2015, Volume: 26, Issue:1

    Topics: Case-Control Studies; Creatinine; Cross-Sectional Studies; Electrolytes; Female; Humans; Male; Middl

2015
Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters.
    Thyroid : official journal of the American Thyroid Association, 2015, Volume: 25, Issue:10

    Topics: Aged; Aged, 80 and over; Female; Humans; Kidney Function Tests; Male; Middle Aged; Renal Dialysis; R

2015
Remarks about the study on evaluation of thyroid hormone levels in chronic kidney disease patients.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2016, Volume: 27, Issue:3

    Topics: Female; Humans; Male; Renal Insufficiency, Chronic; Thyrotropin; Thyroxine; Triiodothyronine

2016
Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2017, Nov-01, Volume: 32, Issue:11

    Topics: Atherosclerosis; Biomarkers; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hy

2017
Albuminuria is an independent risk factor of T4 elevation in chronic kidney disease.
    Scientific reports, 2017, 01-24, Volume: 7

    Topics: Albuminuria; Creatinine; Female; Glomerular Filtration Rate; Humans; Male; Prevalence; Renal Insuffi

2017
Thyroid hormone replacement therapy for primary hypothyroidism leads to significant improvement of renal function in chronic kidney disease patients.
    Clinical and experimental nephrology, 2013, Volume: 17, Issue:4

    Topics: Adult; Aged; Female; Glomerular Filtration Rate; Hormone Replacement Therapy; Humans; Hypothyroidism

2013
Thyroid hormone replacement therapy attenuates the decline of renal function in chronic kidney disease patients with subclinical hypothyroidism.
    Thyroid : official journal of the American Thyroid Association, 2013, Volume: 23, Issue:6

    Topics: Aged; Disease Progression; Down-Regulation; Female; Follow-Up Studies; Glomerular Filtration Rate; H

2013