thyroxine has been researched along with Cardiovascular Stroke in 146 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Excerpt | Relevance | Reference |
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" We have designed protocols for a prospective observational study to assess the association of thyroid function at the time of acute myocardial infarction (AMI) with cardiovascular outcomes, and a double-blinded randomised placebo-controlled trial of levothyroxine to evaluate its effect on LV function and vascular health." | 9.20 | Thyroxine in acute myocardial infarction (ThyrAMI) - levothyroxine in subclinical hypothyroidism post-acute myocardial infarction: study protocol for a randomised controlled trial. ( Ingoe, L; Jabbar, A; Pearce, S; Razvi, S; Zaman, A, 2015) |
"The lipid-lowering effect of etiroxate was studied in a double-blind cross-over trial comprising 183 patients with hyperlipoproteinaemia, most of whom had suffered myocardial infarction or exhibited confirmed coronary insufficiency." | 9.04 | [The effect of etiroxate on serum lipids after myocardial infarction or in angina pectoris]. ( Etzel, V; Hoffmann, H; Nijssen, J; Schwartzkopff, W, 1976) |
"Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic blocking agents in a myocardial infarction (MI) model induced by left coronary occlusion in rats." | 7.91 | Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats. ( Araujo, IG; Império, GE; Marassi, MP; Mecawi, AS; Olivares, EL; Reis, LC; Seara, FAC; Silva, ACM, 2019) |
"Hypothyroidism has detrimental effects on the cardiovascular system, but controversy remains concerning the benefits of levothyroxine (L-T4) substitution in patients with heart failure (HF)." | 7.91 | Long-Term Outcome in Patients With Heart Failure Treated With Levothyroxine: An Observational Nationwide Cohort Study. ( Einfeldt, MN; Faber, J; Gislason, GH; Khalid, U; Kristensen, SL; Olsen, AS; Selmer, C; Torp-Pedersen, C, 2019) |
" Oxidative stress present in heart failure (HF) and myocardial infarction (MI) might cause Se deficiency and decreased thyroxine to triiodothyronine conversion." | 7.91 | Selenium deficiency and the dynamics of changes of thyroid profile in patients with acute myocardial infarction and chronic heart failure. ( Czubek, U; Frączek-Jucha, M; Gackowski, A; Kabat, M; Nessler, J; Szlósarczyk, B, 2019) |
"Our study revealed no evidence that L-thyroxine could increase bleeding risk in patients receiving VKAs." | 7.85 | Assessment of the Impact of L-Thyroxine Therapy on Bleeding Risk in Patients Receiving Vitamin K Antagonists. ( Barres, A; Batisse, M; Dutheil, F; Malhomme, R; Moustafa, F; Pereira, B; Saint-Denis, J; Schmidt, J, 2017) |
"Subclinical hypothyroidism is associated with a number of cardiovascular risk factors, yet only limited data exist on long-term outcome of levothyroxine treatment of this condition with respect to hard end-points." | 7.81 | Levothyroxine Substitution in Patients with Subclinical Hypothyroidism and the Risk of Myocardial Infarction and Mortality. ( Andersen, MN; Faber, J; Gislason, GH; Madsen, JC; Olsen, AM; Selmer, C; Torp-Pedersen, C, 2015) |
" We examined the correlation between altered levels of thyrotropin, free thyroxine, and triiodothyronine (T3) and high-sensitivity cardiac troponin T (hs-cTnT) in 250 patients (mean age 60 years; 42% men) with chest pain, who were free of coronary heart disease and heart failure." | 7.79 | Relation of triiodothyronine to subclinical myocardial injury in patients with chest pain. ( Choi, DH; Ha, JM; Han, JY; Kim, BB; Ku, YH; Park, G; Song, H, 2013) |
"To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction (STEMI)." | 7.77 | Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction. ( Cao, KJ; Guo, CY; Jia, EZ; Li, L; Ma, WZ; Wang, LS; Yang, J; Yang, ZJ; Zhu, TB, 2011) |
"Amiodarone-induced thyrotoxicosis is a life-threatening condition." | 7.74 | Combination of minimally invasive thyroid surgery and local anesthesia associated to iopanoic acid for patients with amiodarone-induced thyrotoxicosis and severe cardiac disorders: a pilot study. ( Ambrosini, CE; Berti, P; Bogazzi, F; Martino, E; Materazzi, G; Miccoli, P, 2007) |
"High values for the free thyroxine fraction were found in the serum of 24 patients during the early phase of myocardial infarction." | 7.67 | Free thyroxine in myocardial infarction. ( Kirkeby, K; Kirkeby, OJ; Risöe, C, 1984) |
"The effects of treatment with L-thyroxine (T4) for 10-12 days on left ventricular (LV) function and myosin isoenzyme content in rats with LV dysfunction after myocardial infarction were studied." | 7.67 | Effects of 10- to 12-day treatment with L-thyroxine in rats with myocardial infarction. ( Aguirre, M; Gay, RG; Goldman, S; Graham, S; Morkin, E, 1988) |
"Serial measurements of haematocrit (Ht), plasma thyroxine (T4), triiodothyronine (T3) and alpha-hydroxybutyrate dehydroxygenase (alpha-HBDH) were performed in patients following myocardial infarction (MI)." | 7.66 | Lowering of serum 3,3',5-triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury. ( Bos, G; Docter, R; Gerbrandy, J; Hennemann, G; Smith, SJ; Visser, TJ, 1978) |
"The serum levels of thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (reverse T3, rT3), thyroxine-binding globulin and thyroid-stimulating hormone have been monitored in 13 patients with acute myocardial infarction." | 7.65 | Divergent changes of serum 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine in patients with acute myocardial infarction. ( Burger, A; Levin, K; Melander, A; Nilsson, G; Pettersson, U; Westgren, U, 1977) |
"The prevalence of low T3 syndrome was 11." | 5.51 | Low triiodothyronine syndrome and serum selenium status in the course of acute myocardial infarction. ( Czubek, U; Frączek-Jucha, M; Gackowski, A; Kabat, M; Nessler, J; Szlósarczyk, B, 2019) |
"In patients with newly treated hypothyroidism, cardiovascular event rates were similar for generic and brand L-T4." | 5.51 | Comparison of Incident Cardiovascular Event Rates Between Generic and Brand l-Thyroxine for the Treatment of Hypothyroidism. ( Bernet, V; Kusumoto, F; Mwangi, R; Sangaralingham, LR; Smallridge, RC; Van Houten, H, 2019) |
"When the lymphoma was in remission, her circulating T3 concentration was 2-55 nmol/l but when it relapsed it fell to 0-55 nmol/l." | 5.26 | Inhibition of conversion of thyroxine to triiodothyronine in patients with severe chronic illness. ( Carter, JN; Corcoran, JM; Eastmen, CJ; Lazarus, L, 1976) |
" We have designed protocols for a prospective observational study to assess the association of thyroid function at the time of acute myocardial infarction (AMI) with cardiovascular outcomes, and a double-blinded randomised placebo-controlled trial of levothyroxine to evaluate its effect on LV function and vascular health." | 5.20 | Thyroxine in acute myocardial infarction (ThyrAMI) - levothyroxine in subclinical hypothyroidism post-acute myocardial infarction: study protocol for a randomised controlled trial. ( Ingoe, L; Jabbar, A; Pearce, S; Razvi, S; Zaman, A, 2015) |
"Serum levels of T4, T3 rT3 and resin T3 uptake were followed for 5 days in 40 patients with acute myocardial infarction (AMI) allocated to early treatment either with alprenolol or placebo." | 5.05 | "Low T3-syndrome" in acute myocardial infarction--relationship to beta-adrenergic blockade and clinical course. ( Pedersen, F; Perrild, H; Rasmussen, SL; Skovsted, L, 1984) |
"The lipid-lowering effect of etiroxate was studied in a double-blind cross-over trial comprising 183 patients with hyperlipoproteinaemia, most of whom had suffered myocardial infarction or exhibited confirmed coronary insufficiency." | 5.04 | [The effect of etiroxate on serum lipids after myocardial infarction or in angina pectoris]. ( Etzel, V; Hoffmann, H; Nijssen, J; Schwartzkopff, W, 1976) |
"It is still not clear how the free triiodothyronine (FT3) to free thyroxine (FT4) ratio affects the prognosis of acute myocardial infarction (AMI), especially the risk of heart failure (HF) subsequent to AMI." | 4.31 | Higher Peripheral Thyroid Sensitivity Is Linked to a Lower Risk of Heart Failure After Acute Myocardial Infarction. ( Fang, S; Lang, X; Li, L; Li, Y; Li, Z; Wu, N; Xing, L; Zhang, Y; Zhao, B, 2023) |
" Consecutive patients without previous thyroid disease presenting with both ST-elevation AMI (STEMI) and non-ST-elevation AMI (NSTEMI) were recruited to the Thyroxine in Acute Myocardial Infarction 1 (ThyrAMI-1) cohort study between December 2014 and 2016." | 4.02 | Prevalence, predictors and outcomes of thyroid dysfunction in patients with acute myocardial infarction: the ThyrAMI-1 study. ( Addison, C; Austin, D; Carey, P; Greenwood, JP; Ingoe, L; Jabbar, A; Junejo, S; Razvi, S; Thomas, H; Vernazza, J; Zaman, A, 2021) |
"Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic blocking agents in a myocardial infarction (MI) model induced by left coronary occlusion in rats." | 3.91 | Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats. ( Araujo, IG; Império, GE; Marassi, MP; Mecawi, AS; Olivares, EL; Reis, LC; Seara, FAC; Silva, ACM, 2019) |
" Oxidative stress present in heart failure (HF) and myocardial infarction (MI) might cause Se deficiency and decreased thyroxine to triiodothyronine conversion." | 3.91 | Selenium deficiency and the dynamics of changes of thyroid profile in patients with acute myocardial infarction and chronic heart failure. ( Czubek, U; Frączek-Jucha, M; Gackowski, A; Kabat, M; Nessler, J; Szlósarczyk, B, 2019) |
"Hypothyroidism has detrimental effects on the cardiovascular system, but controversy remains concerning the benefits of levothyroxine (L-T4) substitution in patients with heart failure (HF)." | 3.91 | Long-Term Outcome in Patients With Heart Failure Treated With Levothyroxine: An Observational Nationwide Cohort Study. ( Einfeldt, MN; Faber, J; Gislason, GH; Khalid, U; Kristensen, SL; Olsen, AS; Selmer, C; Torp-Pedersen, C, 2019) |
"Our study revealed no evidence that L-thyroxine could increase bleeding risk in patients receiving VKAs." | 3.85 | Assessment of the Impact of L-Thyroxine Therapy on Bleeding Risk in Patients Receiving Vitamin K Antagonists. ( Barres, A; Batisse, M; Dutheil, F; Malhomme, R; Moustafa, F; Pereira, B; Saint-Denis, J; Schmidt, J, 2017) |
"Subclinical hypothyroidism is associated with a number of cardiovascular risk factors, yet only limited data exist on long-term outcome of levothyroxine treatment of this condition with respect to hard end-points." | 3.81 | Levothyroxine Substitution in Patients with Subclinical Hypothyroidism and the Risk of Myocardial Infarction and Mortality. ( Andersen, MN; Faber, J; Gislason, GH; Madsen, JC; Olsen, AM; Selmer, C; Torp-Pedersen, C, 2015) |
" We examined the correlation between altered levels of thyrotropin, free thyroxine, and triiodothyronine (T3) and high-sensitivity cardiac troponin T (hs-cTnT) in 250 patients (mean age 60 years; 42% men) with chest pain, who were free of coronary heart disease and heart failure." | 3.79 | Relation of triiodothyronine to subclinical myocardial injury in patients with chest pain. ( Choi, DH; Ha, JM; Han, JY; Kim, BB; Ku, YH; Park, G; Song, H, 2013) |
"3,5,3'-Levo-triiodothyronine (L-T3) is essential for DNA transcription, mitochondrial biogenesis and respiration, but its circulating levels rapidly decrease after myocardial infarction (MI)." | 3.77 | Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats. ( Ardehali, H; Cecchetti, F; Forini, F; Ghanefar, M; Ichikawa, Y; Iervasi, G; Lionetti, V; Nannipieri, M; Nicolini, G; Pucci, A; Recchia, FA, 2011) |
"To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction (STEMI)." | 3.77 | Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction. ( Cao, KJ; Guo, CY; Jia, EZ; Li, L; Ma, WZ; Wang, LS; Yang, J; Yang, ZJ; Zhu, TB, 2011) |
"Amiodarone-induced thyrotoxicosis is a life-threatening condition." | 3.74 | Combination of minimally invasive thyroid surgery and local anesthesia associated to iopanoic acid for patients with amiodarone-induced thyrotoxicosis and severe cardiac disorders: a pilot study. ( Ambrosini, CE; Berti, P; Bogazzi, F; Martino, E; Materazzi, G; Miccoli, P, 2007) |
"In patients with acute myocardial infarction (AMI), low triiodothyronine (T(3)) levels with normal or subnormal levels of thyrotropin (TSH), the euthyroid sick syndrome (ESS), have been reported, however, the mechanism of altered thyroid hormone metabolism is unknown." | 3.70 | Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. ( Fukumura, Y; Kanda, T; Kimura, T; Kobayashi, I; Kotajima, N; Kuwabara, A, 2000) |
"High values for the free thyroxine fraction were found in the serum of 24 patients during the early phase of myocardial infarction." | 3.67 | Free thyroxine in myocardial infarction. ( Kirkeby, K; Kirkeby, OJ; Risöe, C, 1984) |
" In the present study we made serial measurements of serum concentration of thyroid hormones [triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), reverse triiodothyronine (rT3)], thyroid stimulating hormone (TSH) and thyroxine binding globulin (TBG) in 10 patients with acute myocardial infarction (AMI, Grade I, according to the classification of Killip & Forrester) during 14 days after onset." | 3.67 | [Change in serum thyroid hormone levels in patients with acute myocardial infarction]. ( Aono, T; Iwase, K; Kataoka, K; Masunaga, R; Nagasaka, A; Nakagawa, H; Nakai, A; Ohtani, S; Ohyama, T; Shinoda, S, 1987) |
"The effects of treatment with L-thyroxine (T4) for 10-12 days on left ventricular (LV) function and myosin isoenzyme content in rats with LV dysfunction after myocardial infarction were studied." | 3.67 | Effects of 10- to 12-day treatment with L-thyroxine in rats with myocardial infarction. ( Aguirre, M; Gay, RG; Goldman, S; Graham, S; Morkin, E, 1988) |
"The state of the hypophysis-thyroid system was studied by determining the blood content of thyreotropic hormone, thyroxine, triiodothyronine and assessing the iodine-cumulating function of the thyroid gland 24--48 hours after the beginning of the myocardial infarction and return of the S--T interval to the electrical isoline." | 3.66 | [Hypophyseal-thyroid system in the dynamics of complicated and uncomplicated myocardial infarct]. ( Kuimov, AD; Nabulin, MS, 1982) |
"In 21 males (age 50-78 yrs) without endocrine diseases, plasma thyroxine, triiodothyronine, reverse-triiodothyronine and TSH were determined by specific RIAs in the early stage of an acute myocardial infarction." | 3.66 | [Plasma thyroid hormones and TSH during the early stage of acute myocardial infarction (author's transl)]. ( Geisthövel, W; Hehrmann, R; Klein, H; Ködding, R; Perschke, B; von zur Mühlen, A, 1980) |
"Serial measurements of haematocrit (Ht), plasma thyroxine (T4), triiodothyronine (T3) and alpha-hydroxybutyrate dehydroxygenase (alpha-HBDH) were performed in patients following myocardial infarction (MI)." | 3.66 | Lowering of serum 3,3',5-triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury. ( Bos, G; Docter, R; Gerbrandy, J; Hennemann, G; Smith, SJ; Visser, TJ, 1978) |
" We have, therefore, investigated the serum concentrations of total thyroxine (T4), total T3 and total 3,3',5'-triiodothyronine (reverse T3)--the metabolically-inactive metabolite of thyroxine--and of TSH in 13 patients with acute myocardial infarction, in 12 patients with compensated liver cirrhosis, in 9 patients with decompensated liver cirrhosis and in 15 patients with chronic renal failure on chronic intermittent haemodialysis by radioimmunoassay." | 3.66 | [Serum concentrations of thyroid hormones in severe non-thyroidal illnesses (author's transl)]. ( Fritzsche, H; Kolbe, H; Seyfried, H; Stummvoll, HK; Weissel, M; Wolf, A, 1978) |
"The serum levels of thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (reverse T3, rT3), thyroxine-binding globulin and thyroid-stimulating hormone have been monitored in 13 patients with acute myocardial infarction." | 3.65 | Divergent changes of serum 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine in patients with acute myocardial infarction. ( Burger, A; Levin, K; Melander, A; Nilsson, G; Pettersson, U; Westgren, U, 1977) |
"Within the first 36 hours following myocardial infarction, serum total thyroxine (T4) levels were supranormal in most cases in contrast to normal thyrotropin values." | 3.65 | Pituitary-thyroid axis reaction after myocardial infarction. ( Bastenie, PA; Degaute, JP; Golstein, J; Vanhaelst, L, 1976) |
" Today it still remains unclear whether the change in the bioavailability of thyroid hormones in the myocardium is a favorable physiological mechanism or a replication of an adaptation disorder." | 2.66 | [Use of thyroid hormones in the treatment of cardiovascular diseases: literature review]. ( Borisov, DV; Gubaeva, DN; Praskurnichiy, EA, 2020) |
"Alprenolol and placebo were gradually withdrawn over 14 days." | 2.65 | Long-term alprenolol treatment affects serum T4, T3 and rT3 in euthyroid patients with ischaemic heart disease. ( Jürgensen, HJ; Pedersen, F; Perrild, H; Rasmussen, SL; Skovsted, L, 1984) |
"In patients with newly treated hypothyroidism, cardiovascular event rates were similar for generic and brand L-T4." | 1.51 | Comparison of Incident Cardiovascular Event Rates Between Generic and Brand l-Thyroxine for the Treatment of Hypothyroidism. ( Bernet, V; Kusumoto, F; Mwangi, R; Sangaralingham, LR; Smallridge, RC; Van Houten, H, 2019) |
"The prevalence of low T3 syndrome was 11." | 1.51 | Low triiodothyronine syndrome and serum selenium status in the course of acute myocardial infarction. ( Czubek, U; Frączek-Jucha, M; Gackowski, A; Kabat, M; Nessler, J; Szlósarczyk, B, 2019) |
"The incidence of cerebral infarction is increased in patients with NFPA irrespective of GHRT." | 1.48 | Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement ( Bengtsson, O; Bryngelsson, IL; Hammarstrand, C; Johannsson, G; Olsson, DS; Ragnarsson, O, 2018) |
" In conclusion, TH effects seem to involve a modulation of eNOS expression and an improvement in NO bioavailability in the infarcted heart." | 1.42 | T3 and T4 decrease ROS levels and increase endothelial nitric oxide synthase expression in the myocardium of infarcted rats. ( Belló-Klein, A; Campos, C; Conzatti, A; da Rosa Araujo, AS; de Castro, AL; Fernandes, RO; Fernandes, TR; Llesuy, S; Sartório, CL; Schenkel, PC; Siqueira, R; Tavares, AV, 2015) |
"Patients with hypothyroidism have an increased risk of coronary artery disease because of significant changes in lipid metabolism and arterial hypertension." | 1.34 | Acute myocardial infarction following hormone replacement in hypothyroidism. ( Mori, K; Oe, K; Yamagata, T, 2007) |
"Cardiac hypertrophy was evident in AMI hearts after 13 weeks but not at 2 weeks." | 1.34 | Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. ( Cokkinos, DV; Dimopoulos, A; Kokkinos, AD; Kostopanagiotou, G; Markakis, K; Mourouzis, I; Panagiotou, M; Pantos, C; Saranteas, T; Xinaris, C, 2007) |
"After coronary revascularization, a thyrotoxic storm developed and the patient's cardiac failure changed into a hyperdynamic circulation without obvious changes in the patient's vital signs." | 1.33 | Acute myocardial infarction and thyrotoxic storm--a difficult and dangerous combination. ( Eritsland, J; Opdahl, H; Søvik, E, 2005) |
"Overt hypothyroidism has been found to be associated with cardiovascular disease." | 1.32 | Thyroid function is associated with presence and severity of coronary atherosclerosis. ( Auer, J; Berent, R; Eber, B; Lassnig, E; Weber, T, 2003) |
"Hyperthyroidism is a reason for immediately suspending treatment for 90% of the cardiologists, only 5% would continue and 16% would prescribe antithyroid drugs." | 1.30 | [Amiodarone and thyroid function: clinical implications]. ( Binz, K; Burger, A; Vallotton, MB, 1998) |
"The present study demonstrates a change occurring in the creatine-kinase isoenzyme profile of cardiomyocyte cultures induced by a chronic administration of excessive amounts of thyroid hormones (TH)." | 1.28 | Thyroxine-induced redistribution of creatine kinase isoenzymes in rat cardiomyocyte cultures. ( Alkaslassi, L; Brik, H; Harell, D; Shainberg, A; Sperling, O, 1989) |
"The triiodothyronine level was lower on the 2nd day of the disease, the thyroxine content decreased on the 10th day of the disease but became normal on the 20-25th day." | 1.26 | [Thyroid hormones, cholesterol, erythrocyte aggregation and fibrinogen degradation products in acute myocardial infarct]. ( Kellner, K; Liusov, VA; Marek, H; Rudakov, AV; Titlbach, O, 1980) |
"When the lymphoma was in remission, her circulating T3 concentration was 2-55 nmol/l but when it relapsed it fell to 0-55 nmol/l." | 1.26 | Inhibition of conversion of thyroxine to triiodothyronine in patients with severe chronic illness. ( Carter, JN; Corcoran, JM; Eastmen, CJ; Lazarus, L, 1976) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 75 (51.37) | 18.7374 |
1990's | 8 (5.48) | 18.2507 |
2000's | 19 (13.01) | 29.6817 |
2010's | 38 (26.03) | 24.3611 |
2020's | 6 (4.11) | 2.80 |
Authors | Studies |
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Chubb, SAP | 1 |
Peters, KE | 1 |
Bruce, DG | 1 |
Davis, WA | 1 |
Davis, TME | 1 |
Lang, X | 1 |
Zhao, B | 1 |
Fang, S | 1 |
Li, L | 2 |
Li, Z | 1 |
Wu, N | 1 |
Zhang, Y | 4 |
Xing, L | 1 |
Li, Y | 3 |
Frączek-Jucha, M | 2 |
Szlósarczyk, B | 2 |
Kabat, M | 2 |
Czubek, U | 2 |
Nessler, J | 2 |
Gackowski, A | 2 |
Seara, FAC | 1 |
Araujo, IG | 2 |
Império, GE | 1 |
Marassi, MP | 2 |
Silva, ACM | 1 |
Mecawi, AS | 1 |
Reis, LC | 1 |
Olivares, EL | 2 |
Schmutz, JL | 1 |
Jabbar, A | 3 |
Ingoe, L | 2 |
Thomas, H | 1 |
Carey, P | 1 |
Junejo, S | 1 |
Addison, C | 1 |
Vernazza, J | 1 |
Austin, D | 1 |
Greenwood, JP | 1 |
Zaman, A | 2 |
Razvi, S | 3 |
Ortiz, VD | 3 |
Türck, P | 2 |
Teixeira, R | 1 |
Belló-Klein, A | 7 |
de Castro, AL | 7 |
Araujo, ASDR | 1 |
Borisov, DV | 1 |
Gubaeva, DN | 1 |
Praskurnichiy, EA | 1 |
Moustafa, F | 1 |
Malhomme, R | 1 |
Pereira, B | 1 |
Barres, A | 1 |
Saint-Denis, J | 1 |
Dutheil, F | 1 |
Batisse, M | 1 |
Schmidt, J | 1 |
Teixeira, RB | 2 |
Zimmer, A | 2 |
de Lima-Seolin, BG | 1 |
Siqueira, R | 5 |
Singal, PK | 1 |
da Rosa Araujo, AS | 5 |
Gouveia, A | 1 |
De Alencastro, L | 1 |
Fierz, Y | 1 |
Koehli, L | 1 |
Béguelin, A | 1 |
Pasche, O | 1 |
Selby, K | 1 |
Bodenmann, P | 1 |
Carraro, CC | 1 |
Casali, KR | 1 |
Dias, IGM | 1 |
Godoy, AEG | 1 |
Litvin, IE | 1 |
Zhang, K | 1 |
Tang, YD | 1 |
Ojamaa, K | 1 |
Saini, AS | 1 |
Carrillo-Sepulveda, MA | 1 |
Rajagopalan, V | 1 |
Gerdes, AM | 5 |
Yu, T | 1 |
Tian, C | 1 |
Song, J | 1 |
He, D | 1 |
Wu, J | 1 |
Wen, Z | 1 |
Sun, Z | 2 |
Hammarstrand, C | 1 |
Ragnarsson, O | 1 |
Bengtsson, O | 1 |
Bryngelsson, IL | 1 |
Johannsson, G | 1 |
Olsson, DS | 1 |
Einfeldt, MN | 1 |
Olsen, AS | 1 |
Kristensen, SL | 1 |
Khalid, U | 1 |
Faber, J | 2 |
Torp-Pedersen, C | 2 |
Gislason, GH | 2 |
Selmer, C | 2 |
Smallridge, RC | 1 |
Sangaralingham, LR | 1 |
Mwangi, R | 1 |
Kusumoto, F | 1 |
Van Houten, H | 1 |
Bernet, V | 1 |
Chen, YF | 1 |
Weltman, NY | 1 |
Li, X | 1 |
Youmans, S | 1 |
Krause, D | 1 |
Ha, CE | 1 |
Bhagavan, NV | 1 |
Jorde, R | 1 |
Schirmer, H | 1 |
Wilsgaard, T | 1 |
Joakimsen, RM | 1 |
Mathiesen, EB | 1 |
Njølstad, I | 1 |
Løchen, ML | 1 |
Figenschau, Y | 1 |
Svartberg, J | 1 |
Hutchinson, MS | 1 |
Kjærgaard, M | 1 |
Jørgensen, L | 1 |
Grimnes, G | 1 |
Tavares, AV | 4 |
Campos, C | 4 |
Fernandes, RO | 4 |
Conzatti, A | 3 |
Bicca, AM | 1 |
Fernandes, TR | 4 |
Sartório, CL | 2 |
Schenkel, PC | 3 |
Kim, DH | 1 |
Choi, DH | 2 |
Kim, HW | 1 |
Choi, SW | 1 |
Kim, BB | 2 |
Chung, JW | 1 |
Koh, YY | 1 |
Chang, KS | 1 |
Hong, SP | 1 |
Dedkov, EI | 1 |
Lee, B | 1 |
Pun, K | 1 |
Pearce, S | 1 |
Andersen, MN | 1 |
Olsen, AM | 1 |
Madsen, JC | 1 |
Llesuy, S | 1 |
Jankauskienė, E | 1 |
Orda, P | 1 |
Rumbinaitė, E | 1 |
Žaliaduonytė-Pekšienė, D | 1 |
Steponavičiutė, R | 1 |
Krasauskienė, A | 1 |
Vaškelytė, JJ | 1 |
Bunevičius, R | 2 |
Bonetto, JH | 1 |
Corssac, GB | 1 |
Araujo, AS | 1 |
Brozaitiene, J | 1 |
Mickuviene, N | 1 |
Podlipskyte, A | 1 |
Burkauskas, J | 1 |
Vaidya, B | 1 |
Pearce, SH | 1 |
Patanè, S | 1 |
Marte, F | 1 |
Forini, F | 1 |
Lionetti, V | 1 |
Ardehali, H | 1 |
Pucci, A | 1 |
Cecchetti, F | 1 |
Ghanefar, M | 1 |
Nicolini, G | 1 |
Ichikawa, Y | 1 |
Nannipieri, M | 1 |
Recchia, FA | 1 |
Iervasi, G | 3 |
Kalofoutis, C | 1 |
Mourouzis, I | 5 |
Galanopoulos, G | 2 |
Dimopoulos, A | 3 |
Perimenis, P | 1 |
Spanou, D | 1 |
Cokkinos, DV | 6 |
Singh, J | 1 |
Pantos, C | 6 |
Talukder, MA | 1 |
Yang, F | 1 |
Nishijima, Y | 1 |
Chen, CA | 1 |
Xie, L | 1 |
Mahamud, SD | 1 |
Kalyanasundaram, A | 1 |
Bonagura, JD | 1 |
Periasamy, M | 1 |
Zweier, JL | 1 |
Lymvaios, I | 1 |
Dimopoulos, MA | 1 |
Toumanidis, ST | 1 |
Pingitore, A | 1 |
Chen, Y | 1 |
Guo, CY | 1 |
Yang, J | 1 |
Jia, EZ | 1 |
Zhu, TB | 1 |
Wang, LS | 1 |
Cao, KJ | 1 |
Ma, WZ | 1 |
Yang, ZJ | 1 |
Mantzouratou, P | 1 |
Kostakou, E | 1 |
Roukounakis, N | 1 |
Kokkinos, AD | 3 |
Asvold, BO | 1 |
Bjøro, T | 1 |
Platou, C | 1 |
Vatten, LJ | 1 |
Ku, YH | 1 |
Han, JY | 1 |
Ha, JM | 1 |
Park, G | 1 |
Song, H | 1 |
Deicher, R | 1 |
Vierhapper, H | 1 |
Gowda, RM | 1 |
Khan, IA | 1 |
Soodini, G | 1 |
Vasavada, BC | 1 |
Sacchi, TJ | 1 |
CESSION, G | 1 |
BROUHON, N | 1 |
DELEIXHE, A | 1 |
HUMBET, L | 1 |
BEST, MM | 1 |
DUNCAN, CH | 1 |
FELDMAN, EB | 1 |
CARTER, AC | 1 |
ACKERMAN, RF | 1 |
RAAB, W | 1 |
BLACKET, RB | 1 |
WOODHILL, J | 1 |
BROWN, WD | 1 |
HUME, R | 1 |
DREYFUSS, F | 1 |
ROGEL, S | 1 |
GUTTMAN, S | 1 |
GROSS, J | 1 |
Auer, J | 1 |
Berent, R | 1 |
Weber, T | 1 |
Lassnig, E | 1 |
Eber, B | 2 |
BJERKELUND, CJ | 1 |
Opdahl, H | 1 |
Eritsland, J | 1 |
Søvik, E | 1 |
Gunduz, H | 1 |
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Yolcu, M | 1 |
Akdemir, R | 1 |
Kanat, M | 1 |
Uyan, C | 1 |
Berti, P | 1 |
Materazzi, G | 1 |
Bogazzi, F | 1 |
Ambrosini, CE | 1 |
Martino, E | 1 |
Miccoli, P | 1 |
Oe, K | 1 |
Yamagata, T | 1 |
Mori, K | 1 |
Xinaris, C | 2 |
Markakis, K | 2 |
Panagiotou, M | 2 |
Saranteas, T | 1 |
Kostopanagiotou, G | 1 |
Grabczewska, Z | 1 |
Białoszyński, T | 1 |
Kubica, J | 1 |
Fortunato, RS | 1 |
da Silva, AC | 1 |
Costa-e-Sousa, RH | 1 |
Mattos, EC | 1 |
Masuda, MO | 1 |
Mulcahey, MA | 1 |
Huang, SA | 1 |
Bianco, AC | 1 |
Carvalho, DP | 1 |
Preobrazhenskiĭ, DV | 1 |
Pedersen, F | 2 |
Perrild, H | 2 |
Rasmussen, SL | 2 |
Skovsted, L | 2 |
Jürgensen, HJ | 1 |
Franklyn, JA | 1 |
Gammage, MD | 1 |
Ramsden, DB | 2 |
Sheppard, MC | 1 |
Dubik, VT | 1 |
Libergant, IuE | 1 |
Kapustina, LV | 1 |
Vlasikova, EK | 1 |
Shaporenko, AI | 1 |
Pimenov, LT | 2 |
Leshchinskiĭ, LA | 1 |
Kahana, L | 1 |
Keidar, S | 1 |
Sheinfeld, M | 1 |
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Kirkeby, OJ | 1 |
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Kirkeby, K | 1 |
Weissel, M | 3 |
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Kuimov, AD | 3 |
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Lada, W | 2 |
Czech, W | 1 |
Kaniewski, M | 1 |
Marek, H | 1 |
Titlbach, O | 1 |
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Liusov, VA | 1 |
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Geisthövel, W | 2 |
Perschke, B | 2 |
Hehrmann, R | 2 |
Ködding, R | 2 |
von zur Mühlen, A | 2 |
Klein, H | 2 |
Ceremuzyński, L | 3 |
Schumacher, M | 1 |
Langsteger, W | 1 |
Zweiker, R | 1 |
Fruhwald, FM | 1 |
Pokan, R | 1 |
Gasser, R | 1 |
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Hsu, RB | 1 |
Huang, TS | 1 |
Chen, YS | 1 |
Chu, SH | 1 |
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Kotzmann, H | 1 |
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Burger, A | 3 |
Vallotton, MB | 1 |
Mönig, H | 1 |
Arendt, T | 1 |
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Kimura, T | 2 |
Kanda, T | 2 |
Kotajima, N | 2 |
Kuwabara, A | 2 |
Fukumura, Y | 2 |
Kobayashi, I | 2 |
Nishino, M | 1 |
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Tamama, K | 1 |
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Tepliakov, AT | 1 |
Karpov, RS | 1 |
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McLarty, DG | 1 |
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Birkhäuser, M | 1 |
Burer, T | 1 |
Busset, R | 1 |
Wildenthal, K | 1 |
Schwartzkopff, W | 1 |
Hoffmann, H | 1 |
Nijssen, J | 1 |
Etzel, V | 1 |
Westgren, U | 1 |
Levin, K | 1 |
Melander, A | 1 |
Nilsson, G | 1 |
Pettersson, U | 1 |
Princé, HP | 1 |
Burr, WA | 1 |
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Hoffenberg, R | 2 |
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Hennemann, G | 1 |
Ljunggren, JG | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Registry of Patient With Antithrombotic Agents Admitted to an Emergency[NCT02706080] | 10 participants (Anticipated) | Observational | 2014-01-31 | Recruiting | |||
Endocrine Changes in Adults Undergoing Cardiac Surgery[NCT03736499] | 500 participants (Anticipated) | Observational | 2018-07-01 | Active, not recruiting | |||
Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction[NCT02512978] | Phase 4 | 160 participants (Anticipated) | Interventional | 2015-08-31 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
13 reviews available for thyroxine and Cardiovascular Stroke
Article | Year |
---|---|
[Use of thyroid hormones in the treatment of cardiovascular diseases: literature review].
Topics: Animals; Cardiovascular Diseases; Humans; Myocardial Infarction; Thyroid Hormones; Thyroxine; Triiod | 2020 |
Novel insights into the pleiotropic effects of human serum albumin in health and disease.
Topics: Biological Transport; Coronary Artery Disease; Crystallography, X-Ray; Fatty Acids; Humans; Islets o | 2013 |
Thyroid disease and vascular risk.
Topics: Cardiovascular Diseases; Humans; Hypothyroidism; Myocardial Infarction; Thyroxine | 2014 |
Management of hypothyroidism in adults.
Topics: Adult; Chronic Disease; Female; Humans; Hypothyroidism; Male; Myocardial Infarction; Pregnancy; Preg | 2008 |
Thyroid replacement therapy and heart failure.
Topics: Animals; Cardiovascular Diseases; Diiodothyronines; Disease Models, Animal; Glomerular Filtration Ra | 2010 |
Acute myocardial infarction and thyroid function: new pathophysiological and therapeutic perspectives.
Topics: Cell Survival; Heart; Humans; Myocardial Infarction; Myocytes, Cardiac; Receptors, Thyroid Hormone; | 2012 |
NEUROGENIC MULTIFOCAL DESTRUCTION OF MYOCARDIAL TISSUE (PATHOGENIC MECHANISM AND ITS PREVENTION).
Topics: Adrenal Cortex Hormones; Catecholamines; Epinephrine; Heart Diseases; Hypoxia; Myocardial Infarction | 1963 |
[New therapeutic possibilities of propranolol].
Topics: Antithyroid Agents; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; | 1984 |
[Effect of non-thyroid diseases on serum concentrations of hormones of the thyroid function regulatory cycle].
Topics: Adolescent; Anorexia Nervosa; Arthritis, Rheumatoid; Female; Humans; Hyperthyroidism; Hypothyroidism | 1982 |
Atrial natriuretic peptides in pathophysiological diseases.
Topics: Acute Kidney Injury; Animals; Arrhythmias, Cardiac; Ascites; Atrial Natriuretic Factor; Cardiovascul | 2001 |
Lysosomes and lysosomal enzymes in the heart.
Topics: Acid Phosphatase; Adrenal Cortex Hormones; Animals; Cardiomegaly; Cathepsins; Centrifugation, Densit | 1975 |
The cholesterol problem, the egg and lipid metabolism in the laying hen.
Topics: Animal Feed; Animals; Arteriosclerosis; Azasteroids; Chickens; Cholesterol; Cholesterol, Dietary; Eg | 1976 |
Lipid changes in thyroid disease: the effect of thyroxine and analogues.
Topics: Animals; Cholesterol; Humans; Hypercholesterolemia; Hyperthyroidism; In Vitro Techniques; Lipid Meta | 1974 |
6 trials available for thyroxine and Cardiovascular Stroke
Article | Year |
---|---|
The relationship between thyroid dysfunction, cardiovascular morbidity and mortality in type 2 diabetes: The Fremantle Diabetes Study Phase II.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypothyroidism; Male; Myocardial Infarction; Stroke | 2022 |
Thyroxine in acute myocardial infarction (ThyrAMI) - levothyroxine in subclinical hypothyroidism post-acute myocardial infarction: study protocol for a randomised controlled trial.
Topics: Asymptomatic Diseases; Biomarkers; Clinical Protocols; Double-Blind Method; England; Female; Humans; | 2015 |
"Low T3-syndrome" in acute myocardial infarction--relationship to beta-adrenergic blockade and clinical course.
Topics: Adrenergic beta-Antagonists; Aged; Alprenolol; Female; Humans; Male; Middle Aged; Myocardial Infarct | 1984 |
Long-term alprenolol treatment affects serum T4, T3 and rT3 in euthyroid patients with ischaemic heart disease.
Topics: Adult; Aged; Alprenolol; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle | 1984 |
[The effect of etiroxate on serum lipids after myocardial infarction or in angina pectoris].
Topics: Angina Pectoris; Blood Coagulation; Clinical Trials as Topic; Heart; Humans; Hypercholesterolemia; L | 1976 |
[Results of the Coronary Drug Project--routine treatment of infarct patients with serum lipid reductants].
Topics: Clinical Trials as Topic; Clofibrate; Estrogens; Humans; Lipids; Myocardial Infarction; Nicotinic Ac | 1975 |
127 other studies available for thyroxine and Cardiovascular Stroke
Article | Year |
---|---|
Higher Peripheral Thyroid Sensitivity Is Linked to a Lower Risk of Heart Failure After Acute Myocardial Infarction.
Topics: Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Retrospective Studies; Thyr | 2023 |
Low triiodothyronine syndrome and serum selenium status in the course of acute myocardial infarction.
Topics: Euthyroid Sick Syndromes; Humans; Hypothyroidism; Myocardial Infarction; Selenium; Thyroxine; Triiod | 2019 |
Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats.
Topics: Adipose Tissue, Brown; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Iodide Peroxida | 2019 |
[Alitretinoin (Toctino®): Recent pharmacovigilance data].
Topics: Abortion, Induced; Adult; Adverse Drug Reaction Reporting Systems; Alitretinoin; Contraception; Derm | 2020 |
Prevalence, predictors and outcomes of thyroid dysfunction in patients with acute myocardial infarction: the ThyrAMI-1 study.
Topics: Autoantibodies; Causality; Correlation of Data; Creatinine; England; Euthyroid Sick Syndromes; Femal | 2021 |
Effects of Carvedilol and Thyroid Hormones Co-administration on Apoptotic and Survival Proteins in the Heart After Acute Myocardial Infarction.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carvedil | 2020 |
Assessment of the Impact of L-Thyroxine Therapy on Bleeding Risk in Patients Receiving Vitamin K Antagonists.
Topics: Aged; Aged, 80 and over; Anticoagulants; Female; Fibrinolytic Agents; Hemorrhage; Humans; Hypertensi | 2017 |
Long-term T3 and T4 treatment as an alternative to aerobic exercise training in improving cardiac function post-myocardial infarction.
Topics: Animals; Biological Transport; Calcium; Cardiac Catheterization; Echocardiography; Heart; Heart Func | 2017 |
[General internal medicine : 2017 scientific breakthroughs in ambulatory care].
Topics: Ambulatory Care; Aspirin; Humans; Internal Medicine; Myocardial Infarction; Platelet Aggregation Inh | 2018 |
Exercise training versus T3 and T4 hormones treatment: The differential benefits of thyroid hormones on the parasympathetic drive of infarcted rats.
Topics: Animals; Echocardiography; Exercise Therapy; Fibrosis; Hypertrophy, Left Ventricular; Male; Myocardi | 2018 |
Comparison of Therapeutic Triiodothyronine Versus Metoprolol in the Treatment of Myocardial Infarction in Rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Echocardiography; Ele | 2018 |
Value of the fT3/fT4 ratio and its combination with the GRACE risk score in predicting the prognosis in euthyroid patients with acute myocardial infarction undergoing percutaneous coronary intervention: a prospective cohort study.
Topics: Aged; Biomarkers; Decision Support Techniques; Female; Humans; Male; Middle Aged; Myocardial Infarct | 2018 |
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement
Topics: Adenoma; Adult; Aged; Cerebral Infarction; Cohort Studies; Comorbidity; Diabetes Mellitus, Type 2; F | 2018 |
Long-Term Outcome in Patients With Heart Failure Treated With Levothyroxine: An Observational Nationwide Cohort Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Female; Follow-Up Studies; Hear | 2019 |
Comparison of Incident Cardiovascular Event Rates Between Generic and Brand l-Thyroxine for the Treatment of Hypothyroidism.
Topics: Adult; Aged; Atrial Fibrillation; Drugs, Generic; Female; Humans; Hypothyroidism; Insurance Claim Re | 2019 |
Selenium deficiency and the dynamics of changes of thyroid profile in patients with acute myocardial infarction and chronic heart failure.
Topics: Aged; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Poland; Selenium; Thy | 2019 |
Improvement of left ventricular remodeling after myocardial infarction with eight weeks L-thyroxine treatment in rats.
Topics: Animals; Arterioles; Body Weight; Collagen; Echocardiography; Female; Myocardial Infarction; Organ S | 2013 |
The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction, and body height: the Tromsø study.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Body Height; Cardiovascular Diseases; Diabetes Mel | 2014 |
Cardioprotective effects of thyroid hormones in a rat model of myocardial infarction are associated with oxidative stress reduction.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catalase; Disease Models, Animal; Glutathione Disulfide; | 2014 |
Prediction of infarct severity from triiodothyronine levels in patients with ST-elevation myocardial infarction.
Topics: Aged; Area Under Curve; Biomarkers; Chi-Square Distribution; Contrast Media; Coronary Angiography; F | 2014 |
Thyroid hormone replacement therapy attenuates atrial remodeling and reduces atrial fibrillation inducibility in a rat myocardial infarction-heart failure model.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Disease Models, Animal; Electrocardiography; Female | 2014 |
Levothyroxine Substitution in Patients with Subclinical Hypothyroidism and the Risk of Myocardial Infarction and Mortality.
Topics: Adult; Aged; Female; Humans; Hypothyroidism; Male; Middle Aged; Myocardial Infarction; Thyroxine | 2015 |
T3 and T4 decrease ROS levels and increase endothelial nitric oxide synthase expression in the myocardium of infarcted rats.
Topics: Animals; Disease Models, Animal; Heart Ventricles; Male; Myocardial Infarction; Nitric Oxide; Nitric | 2015 |
Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction.
Topics: Aged; Diastole; Echocardiography; Euthyroid Sick Syndromes; Humans; Middle Aged; Myocardial Infarcti | 2015 |
Thyroid hormones improve cardiac function and decrease expression of pro-apoptotic proteins in the heart of rats 14 days after infarction.
Topics: Animals; Apoptosis Regulatory Proteins; Cardiotonic Agents; Drug Evaluation, Preclinical; Gene Expre | 2016 |
Thyroid hormones effects on oxidative stress and cardiac remodeling in the right ventricle of infarcted rats.
Topics: Animals; Echocardiography; Hydrogen Peroxide; Hypertrophy, Right Ventricular; Myocardial Infarction; | 2016 |
Relationship and prognostic importance of thyroid hormone and N-terminal pro-B-Type natriuretic peptide for patients after acute coronary syndromes: a longitudinal observational study.
Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; C-Reactive Protein; Coronary Artery Disease; Female; | 2016 |
Acute myocardial infarction during l-thyroxine therapy in a patient with intermittent changing axis deviation, permanent atrial fibrillation and without significant coronary stenoses.
Topics: Atrial Fibrillation; Coronary Vessels; Electrocardiography; Female; Humans; Middle Aged; Myocardial | 2010 |
Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats.
Topics: Animals; Apoptosis; Blotting, Western; Capillaries; Cells, Cultured; Hemodynamics; Hormone Replaceme | 2011 |
Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction.
Topics: Animals; Diabetes Mellitus, Experimental; Down-Regulation; Genes, erbA; Myocardial Infarction; Rats; | 2010 |
Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Blotting, Western; Cardiotonic Agents; Data Interpret | 2011 |
Thyroid hormone and recovery of cardiac function in patients with acute myocardial infarction: a strong association?
Topics: Aged; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Thyroxine; T | 2011 |
Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; China; Euthyroid Sick Syndromes; Female; Humans; Inte | 2011 |
[Type 1 diabetes impairs compensatory response after myocardial infarction; role of tissue hypothyroidism and effects of thyroid hormone administration].
Topics: Animals; Diabetes Mellitus, Type 1; Hypothyroidism; Male; Myocardial Infarction; Myocardium; Rats; T | 2011 |
Dose-dependent effects of thyroid hormone on post-ischemic cardiac performance: potential involvement of Akt and ERK signalings.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MA | 2012 |
Thyroid function and the risk of coronary heart disease: 12-year follow-up of the HUNT study in Norway.
Topics: Aged; Coronary Disease; Female; Heart Failure; Hospitalization; Humans; Hypothyroidism; Male; Middle | 2012 |
Relation of triiodothyronine to subclinical myocardial injury in patients with chest pain.
Topics: Aged; Area Under Curve; Biomarkers; Chest Pain; Female; Humans; Logistic Models; Male; Middle Aged; | 2013 |
Homocysteine: a risk factor for cardiovascular disease in subclinical hypothyroidism?
Topics: Adult; Aged; Arteriosclerosis; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypothyroidism; M | 2002 |
Acute myocardial infarction with normal coronary arteries associated with iatrogenic hyperthyroidism.
Topics: Cardiac Catheterization; Female; Humans; Hyperthyroidism; Iatrogenic Disease; Middle Aged; Myocardia | 2003 |
[Comparative value of the determination of oxalacetic transaminase and lactic acid dehydrogenase in the blood for the diagnosis of myocardial infarct].
Topics: Humans; L-Lactate Dehydrogenase; Lactate Dehydrogenases; Lactic Acid; Myocardial Infarction; Oxidore | 1961 |
EFFECTS OF CHOLESTEROL-LOWERING DRUGS ON SERUM TRIGLYCERIDES.
Topics: Androsterone; Angina Pectoris; Arteriosclerosis; Cholesterol; Diabetes Mellitus; Humans; Lipids; Myo | 1964 |
REDUCTION OF SERUM TRIGLYCERIDES IN PATIENTS TREATED WITH SODIUM D-THYROXINE.
Topics: Blood Chemical Analysis; Child; Dextrothyroxine; Glycerides; Hypercholesterolemia; Hyperlipidemias; | 1963 |
PROLONGED ADMINISTRATION OF DEXTROTHYROXINE IN CARDIOVASCULAR PATIENTS.
Topics: Angina Pectoris; Cardiovascular Diseases; Cholesterol; Dextrothyroxine; Diet; Diet Therapy; Humans; | 1964 |
THE EFFECT OF CHOLESTYRAMINE ("MK 135") ON THE SERUM CHOLESTEROL LEVEL IN MAN.
Topics: Angina Pectoris; Cholesterol; Cholestyramine Resin; Coronary Disease; Humans; Leg; Male; Myocardial | 1964 |
FIBRINOLYTIC ACTIVITY AND THYROID FUNCTION.
Topics: Aging; Cholesterol; Fibrinogen; Fibrinolysis; Geriatrics; Hyperthyroidism; Hypothyroidism; Iodine Is | 1965 |
UPTAKE OF I-131-TAGGED SODIUM IODIDE, TRIIODOTHYRONINE, AND THYROXINE BY EXPERIMENTAL MYOCARDIAL INFARCTS IN DOGS.
Topics: Animals; Coronary Vessels; Dogs; Humans; Iodides; Iodine Isotopes; Myocardial Infarction; Pectoralis | 1965 |
Thyroid function is associated with presence and severity of coronary atherosclerosis.
Topics: Adult; Aged; Aged, 80 and over; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studi | 2003 |
[Cardiac infarct during thyroxin therapy of myxedema].
Topics: Meningitis; Myocardial Infarction; Myxedema; Thyroxine | 1952 |
Acute myocardial infarction and thyrotoxic storm--a difficult and dangerous combination.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Antithyroid Agents; Catheterization, Swan-Ganz; Coma; | 2005 |
A case of hypothyroidism mimicking acute coronary syndrome.
Topics: Acute Disease; Cardiac Catheterization; Coronary Angiography; Creatine Kinase; Creatine Kinase, MB F | 2006 |
Combination of minimally invasive thyroid surgery and local anesthesia associated to iopanoic acid for patients with amiodarone-induced thyrotoxicosis and severe cardiac disorders: a pilot study.
Topics: Aged; Amiodarone; Anesthesia, Local; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nerve B | 2007 |
Acute myocardial infarction following hormone replacement in hypothyroidism.
Topics: Aged; Coronary Angiography; Echocardiography; Electrocardiography; Follow-Up Studies; Hormone Replac | 2007 |
Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cell Shape; Echocardiography; In Vitro Techniques; Isomet | 2007 |
[Acute myocardial infarction in a patient with iatrogenic thyrotoxicosis--a case report].
Topics: Adult; Coronary Angiography; Creatine Kinase; Creatine Kinase, MB Form; Electrocardiography; Humans; | 2007 |
Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats.
Topics: Administration, Oral; Animals; Calcium-Binding Proteins; Cardiomegaly; Disease Models, Animal; Echoc | 2007 |
Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.
Topics: Animals; Heart; Iodide Peroxidase; Iodine Radioisotopes; Male; Myocardial Infarction; Myocardium; Ra | 2007 |
Thyroid status in patients after acute myocardial infarction.
Topics: Acute Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prealbumin; Thyroid Hormone | 1984 |
[Thyrotropic-thyroid activity of the blood in patients with various manifestations of ischemic heart disease].
Topics: Adult; Aged; Coronary Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Radioimmuno | 1984 |
[Thyroid hormone changes (iodothyroninemia) in patients with acute myocardial infarction, and their clinical significance].
Topics: Adult; Angina Pectoris; Cardiomyopathy, Dilated; Humans; Middle Aged; Myocardial Infarction; Prognos | 1984 |
[The hypophyseal-thyroid system in myocardial infarction].
Topics: Adult; Female; Humans; Male; Middle Aged; Myocardial Infarction; Pituitary Gland; Radioimmunoassay; | 1984 |
Endogenous cortisol and thyroid hormone levels in patients with acute myocardial infarction.
Topics: Adult; Aged; Circadian Rhythm; Female; Humans; Hydrocortisone; Male; Middle Aged; Myocardial Infarct | 1983 |
Free thyroxine in myocardial infarction.
Topics: Adult; Aged; Fatty Acids, Nonesterified; Humans; Kinetics; Male; Middle Aged; Myocardial Infarction; | 1984 |
[Hypophyseal-thyroid system in the dynamics of complicated and uncomplicated myocardial infarct].
Topics: Adult; Aged; Female; Humans; Iodine Radioisotopes; Male; Middle Aged; Myocardial Infarction; Pituita | 1982 |
Thyroid hormones in acute myocardial infarction.
Topics: Acute Disease; Aged; Aspartate Aminotransferases; Female; Humans; Male; Middle Aged; Myocardial Infa | 1981 |
[Triiodothyronine, reverse triiodothyronine and thyroxine levels in the acute stage of myocardial infarct].
Topics: Aged; Female; Humans; Male; Middle Aged; Myocardial Infarction; Thyroxine; Triiodothyronine; Triiodo | 1981 |
[Thyroid hormones, cholesterol, erythrocyte aggregation and fibrinogen degradation products in acute myocardial infarct].
Topics: Adult; Aged; Angina Pectoris; Cholesterol; Coronary Disease; Erythrocyte Aggregation; Fibrin Fibrino | 1980 |
[Reciprocal changes of triiodothyronine and reverse triiodothyronine in the early stage of myocardial infarction (author's transl)].
Topics: Aged; Humans; Male; Middle Aged; Myocardial Infarction; Thyroid Hormones; Thyrotropin; Thyroxine; Tr | 1980 |
[Catecholamines, thyroid hormones and free fatty acids in acute myocardial infarction (author's transl)].
Topics: Catecholamines; Fatty Acids, Nonesterified; Humans; Myocardial Infarction; Thyroxine; Triiodothyroni | 1980 |
[Plasma thyroid hormones and TSH during the early stage of acute myocardial infarction (author's transl)].
Topics: Aged; Humans; Male; Middle Aged; Myocardial Infarction; Thyroid Hormones; Thyrotropin; Thyroxine; Tr | 1980 |
Changes in thyroid hormone parameters after acute myocardial infarction.
Topics: Aged; Aged, 80 and over; Creatine Kinase; Female; Humans; Isoenzymes; Male; Middle Aged; Myocardial | 1995 |
Effect of triiodothyronine administration in experimental myocardial injury.
Topics: Animals; Fatty Acids, Nonesterified; Heart Injuries; Hemodynamics; Myocardial Infarction; Myocardium | 1995 |
Factitious hyperthyroidism causing acute myocardial infarction.
Topics: Acute Disease; Aged; Factitious Disorders; Female; Humans; Hyperthyroidism; Myocardial Infarction; T | 1995 |
[Amiodarone and thyroid function: clinical implications].
Topics: Amiodarone; Anti-Arrhythmia Agents; Female; Humans; Hyperthyroidism; Male; Myocardial Infarction; Ta | 1998 |
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome.
Topics: Adult; Aged; Critical Care; Cytokines; Euthyroid Sick Syndromes; Female; Humans; Male; Middle Aged; | 1999 |
Excess triiodothyronine as a risk factor of coronary events.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Cross-Sectional Studies; Female; Humans; Logistic M | 2000 |
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction.
Topics: Aged; Creatine Kinase; Euthyroid Sick Syndromes; Female; Humans; Interleukin-6; Kinetics; Male; Midd | 2000 |
Circulating interleukin-6 significantly correlates to thyroid hormone in acute myocardial infarction but not in chronic heart failure.
Topics: Aged; Cardiac Output, Low; Female; Humans; Interleukin-6; Male; Middle Aged; Myocardial Infarction; | 2000 |
[Coronary insufficiency and metabolic hormone ratio in patients with myocardial infarction in the course of a long prospective study].
Topics: Adult; Coronary Artery Disease; Disease Progression; Female; Glucose Tolerance Test; Humans; Hydroco | 2000 |
Thyroid stimulating hormone secretion is a dynamic process.
Topics: Aged; Aged, 80 and over; Female; Humans; Male; Myocardial Infarction; Prolactin; Stress, Physiologic | 2001 |
Rapid down-regulation of thyroid hormones in acute myocardial infarction: is it cardioprotective in patients with angina?
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Biomarkers; Case-Control Studies; Down-Regulation; | 2002 |
Letter: Thyroid-hormone levels and prognosis in patients with serious non-thyroidal illness.
Topics: Cerebrovascular Disorders; Death, Sudden; Humans; Myocardial Infarction; Prognosis; Thyroxine; Triio | 1975 |
Letter: Thyroid hormones in serious non-thyroidal illness.
Topics: Acute Disease; Anemia, Pernicious; Brain Injuries; Chronic Disease; Diabetic Coma; Diabetic Ketoacid | 1976 |
Diagnosis of hyperthyroidism when serum-thyroxine alone is raised.
Topics: Adult; Aged; Delirium; False Negative Reactions; Female; Follow-Up Studies; Gastroenteritis; Graves | 1977 |
Divergent changes of serum 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine in patients with acute myocardial infarction.
Topics: Acute Disease; Adult; Aged; Female; Humans; Male; Middle Aged; Myocardial Infarction; Serum Globulin | 1977 |
The inter-relationship of thyroid hormones, vitamin A and their binding proteins following acute stress.
Topics: Antibodies; Humans; Myocardial Infarction; Prealbumin; Retinol-Binding Proteins; Serum Albumin; Stre | 1978 |
Lowering of serum 3,3',5-triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury.
Topics: Aged; Female; Humans; Hydroxybutyrate Dehydrogenase; Male; Middle Aged; Myocardial Infarction; Thyro | 1978 |
The influence of endogenous cortisol on the peripheral conversion of thyroxine in patients with acute myocardial infarction.
Topics: Acute Disease; Adult; Aged; Female; Humans; Hydrocortisone; Male; Middle Aged; Myocardial Infarction | 1979 |
[Serum concentrations of thyroid hormones in severe non-thyroidal illnesses (author's transl)].
Topics: Humans; Liver Cirrhosis; Myocardial Infarction; Thyroid Hormones; Thyrotropin; Thyroxine; Triiodothy | 1978 |
Patients with intractable angina: free thyroxine index, immunoreactive insulin and free fatty acids in blood, free adrenaline and noradrenaline in urine.
Topics: Adult; Aged; Angina Pectoris; Diabetes Mellitus; Epinephrine; Fatty Acids, Nonesterified; Humans; In | 1978 |
[Treatment of hypercholesterolemia after myocardial infarction with D-thyroxine (author's transl)].
Topics: Angina Pectoris; Blood Pressure; Body Weight; Female; Humans; Hypercholesterolemia; Male; Middle Age | 1975 |
[Myocardial infarction during thyroxin therapy].
Topics: Humans; Myocardial Infarction; Myxedema; Thyroxine | 1977 |
Changes in serum 3,3',5'-triiodothyronine (reverse T3) concentrations with altered thyroid hormone secretion and metabolism.
Topics: Antibody Specificity; Female; Fetal Blood; Humans; Hyperthyroidism; Hypothyroidism; Isomerism; Methi | 1977 |
Inhibition of conversion of thyroxine to triiodothyronine in patients with severe chronic illness.
Topics: Chronic Disease; Humans; Lymphoma; Myocardial Infarction; Thyrotropin; Thyroxine; Triiodothyronine | 1976 |
[Editorial: Myocardial infarct and thyroid hormones].
Topics: Humans; Myocardial Infarction; Thyroid Gland; Thyroid Hormones; Thyroxine | 1975 |
[Assay of serum creatine phosphokinase in primary hypothyroidism. Comparison with other thyroid gland function tests in 32 cases. Value of isoenzyme studies].
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Cholesterol; Creatine Ki | 1975 |
Pituitary-thyroid axis reaction after myocardial infarction.
Topics: Aged; Aspartate Aminotransferases; Creatine Kinase; Female; Humans; Male; Middle Aged; Myocardial In | 1976 |
Hypothyroidism renders protection against lethal ventricular arrhythmias in a conscious canine model of sudden death.
Topics: Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Electroencephalography; Electrophysiolo | 1991 |
[What plays an important role in the secretion of alpha-human atrial natriuretic polypeptide (alpha-hANP) during the early stage of acute myocardial infarction?].
Topics: Adult; Aged; Atrial Natriuretic Factor; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial | 1990 |
Morbidity, mortality, and quality of life for patients treated with levothyroxine.
Topics: Adult; Cerebrovascular Disorders; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Incidence; M | 1990 |
[Change in serum thyroid hormone levels in patients with acute myocardial infarction].
Topics: Aged; Alpha-Globulins; Humans; Middle Aged; Myocardial Infarction; Thyroid Hormones; Thyrotropin; Th | 1987 |
[Effects of early physical rehabilitation of patients with myocardial infarction on the function of the pituitary-thyroid system].
Topics: Adult; Exercise Test; Humans; Male; Myocardial Infarction; Physical Education and Training; Pituitar | 1989 |
Thyroxine-induced redistribution of creatine kinase isoenzymes in rat cardiomyocyte cultures.
Topics: Animals; Cells, Cultured; Creatine Kinase; Gene Expression Regulation; Isoenzymes; Myocardial Infarc | 1989 |
Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.
Topics: Angiography; Coronary Angiography; Coronary Vasospasm; Electrocardiography; Humans; Hypothyroidism; | 1989 |
[The hypothalamo-hypophyseal thyroid axis, plasma protein concentrations and the hypophyseo-gonadal axis in low T3 syndrome following acute myocardial infarct].
Topics: Blood Proteins; Estradiol; Euthyroid Sick Syndromes; Female; Follicle Stimulating Hormone; Gonadotro | 1987 |
[Thyroid hormone metabolism in nonthyroidal illnesses. II. A new method for measuring serum thyroid hormone binding inhibitor and its clinical application].
Topics: Humans; Methods; Myocardial Infarction; Neoplasms; Thyroid Hormones; Thyroxine; Thyroxine-Binding Pr | 1988 |
Effects of 10- to 12-day treatment with L-thyroxine in rats with myocardial infarction.
Topics: Animals; Blood Pressure; Diastole; Dose-Response Relationship, Drug; Heart; Heart Rate; Male; Myocar | 1988 |
[Preliminary study of the relation of acute myocardial infarction and thyroid hormones].
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Thyroxine; Triiodo | 1988 |
[Thyroid hormone metabolism in nonthyroidal illness. I. Changes in thyroid hormone metabolism in dogs with experimental myocardial infarction and effect of thyroid hormone administration on their hemodynamics].
Topics: Animals; Dogs; Hemodynamics; Myocardial Infarction; Thyroxine; Triiodothyronine | 1988 |
[Changes in thyroid hormones in acute myocardial infarction and their clinical significance].
Topics: Aged; Aged, 80 and over; Aspartate Aminotransferases; Female; Humans; Male; Middle Aged; Myocardial | 1986 |
Effects of L-thyroxine in rats with chronic heart failure after myocardial infarction.
Topics: Animals; Chronic Disease; Heart Failure; Isoenzymes; Myocardial Infarction; Myosins; Rats; Rats, Inb | 1987 |
[Effect of an early single physical loading on the concentration of thyrotropin, triiodothyronine, thyroxine and cortisol in the blood of acute myocardial infarct patients].
Topics: Acute Disease; Adult; Exercise Therapy; Humans; Hydrocortisone; Male; Middle Aged; Myocardial Infarc | 1986 |
Evaluation of pituitary-thyroid axis response to acute myocardial infarction.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Myocardial Infarction; Pituitary Gland; Thyroid Horm | 1985 |
[Significance of radioimmunologic studies in the diagnosis, assessment of severity and prognosis of myocardial infarct].
Topics: Aged; Creatine Kinase; Female; Humans; Isoenzymes; Male; Middle Aged; Myocardial Infarction; Myoglob | 1985 |
[The effect of heparin induced increase of free plasma thyroxine on cardiac rhythm after myocardial infarction].
Topics: Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Heparin; Humans; Male; Middle Aged; Monitor | 1985 |
Beta blocking agents and antithyroid drugs as adjuncts to radioiodine therapy.
Topics: Adrenergic beta-Antagonists; Antithyroid Agents; Carbimazole; Chemical Phenomena; Chemistry; Humans; | 1971 |
Long-term administration of 3,5-diodo-4(3'-iodo4'-acetoxyphenoxy) benzoic acid (acetiromate) in hyperlipidemic patients.
Topics: Aged; Cholesterol; Drug Evaluation; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Iodobenzo | 1974 |
[Effect of dysproteinemias on the in-vitro diagnosis of thyroid function].
Topics: Blood Protein Disorders; Cerebral Hemorrhage; Gout; Humans; Myocardial Infarction; Neoplasms; Respir | 1974 |
[Role of magnesium, potassium, antikaliuretic agents and hypocholesteremic agents in cardiac lesion development in rats fed a thrombogenic diet and Na 2 HPO 4 ].
Topics: Animals; Anticholesteremic Agents; Clofibrate; Diet, Atherogenic; Diuretics; Estrogens, Conjugated ( | 1972 |
Supraventricular tachycardia. II.
Topics: Acetanilides; Adrenergic beta-Antagonists; Aged; Amino Alcohols; Angina Pectoris; Arrhythmia, Sinus; | 1971 |
[Diagnosis and therapy of the secondary disease: geriatrics].
Topics: Aged; Central Nervous System Diseases; Cerebrovascular Disorders; Cortisone; Diabetes Mellitus; Digi | 1973 |
[Protein carriers of thyroid gland hormones in patients following myocardial infarct].
Topics: Adult; Aged; Blood Protein Electrophoresis; Female; Globulins; Humans; Male; Middle Aged; Myocardial | 1968 |
Intractable paroxysmal tachycardia in thyrotoxicosis simulating myocardial infarction.
Topics: Angina Pectoris; Atrial Fibrillation; Bradycardia; Cardiac Catheterization; Diagnosis, Differential; | 1972 |
Thyroxine secretion rate after myocardial infarction.
Topics: Adult; Aged; Blood Proteins; Female; Humans; Iodine; Iodine Isotopes; Male; Middle Aged; Myocardial | 1972 |
[Antilipidemic agents].
Topics: Adult; Alcohols; Anticholesteremic Agents; Biguanides; Blood Protein Disorders; Body Weight; Cholest | 1971 |
Carbohydrate, insulin, and lipid interrelationship in ischemic vascular disease.
Topics: Age Factors; Aged; Angina Pectoris; Blood Glucose; Blood Pressure; Body Height; Body Weight; Coronar | 1970 |
Observations on the effect of heparin on free and total thyroxine.
Topics: Heparin; Humans; Myocardial Infarction; Thyroxine; Warfarin | 1971 |
Cardiac effects of cold-induced hyperthyroidism and the seasonal variation in incidence of myocardial infarction.
Topics: Animals; Atropine; Cold Temperature; Heart; Heart Rate; Hyperthyroidism; Male; Myocardial Infarction | 1971 |