thyroxine has been researched along with Cardiomyopathies, Primary in 43 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In 18 requiring thyroxine supplementation for hypothyroidism, 10 were able to discontinue, and four reduced their thyroxine dose." | 5.14 | Normalisation of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassaemia major. ( Berdoukas, V; Chouliaras, G; Farmaki, K; Pappa, C; Tzoumari, I, 2010) |
| "Subclinical thyrotoxicosis is defined as a below normal thyrotropin (TSH) in association with a normal total and free thyroxine (T4) and triiodothyronine (T3)." | 4.81 | Subclinical thyrotoxicosis and the heart. ( Burmeister, LA; Flores, A, 2002) |
| " A rat model of thyrotoxicosis was established by daily intraperitoneal injections of L-thyroxine (T(4), 100 μg/kg) for 4 weeks." | 3.78 | Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy. ( Cho, KI; Choi, BG; Jeon, YK; Kang, JH; Kim, BH; Kim, IJ; Kim, JY; Kim, SJ; Kim, SM; Kim, SS; Kim, YK, 2012) |
| " We hypothesized that CPU86017, derived from berberine, which possesses multi-channel blocking activity, could suppress inflammatory factors, resulting in inhibition of over-expression of ether-a-go-go (ERG) and an augmented incidence of ventricular fibrillation (VF) in ischaemia/reperfusion (I/R)." | 3.74 | Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent. ( Dai, DZ; Dai, Y; Du, RH; Tang, WH; Yi, HW, 2008) |
| " Imidapril and valsartan may exert beneficial effects on hyperthyroid myocardial hypertrophy via altering intracellular calcium handling." | 3.74 | [Renin-angiotensin system blocking agents reverse the myocardial hypertrophy in experimental hyperthyroid cardiomyopathy via altering intracellular calcium handling]. ( Dai, Y; Deng, W; Su, L; Yin, YH, 2008) |
| "A case report is presented of an adolescent male who developed hypothyroidism and cardiomyopathy 6 months after he began taking lithium and imipramine for a severe conduct disorder." | 3.68 | Cardiac toxicity in an adolescent following chronic lithium and imipramine therapy. ( Dietrich, A; Mortensen, ME; Wheller, J, 1993) |
| "In patients with effort syndrome and hyperthyroidism, MTTs were often, but not always shortened below the control values; consequently, in case of associated heart disease, MTT-prolongation may be masked in such instances where hyperthyroidism causes MTT shortening." | 1.25 | [Minimal cardiac transit time in thyroid disorders and in the effort syndrome]. ( Becker, V; Feinendegen, LE; Schicha, H; Siebers, G; Vyska, K, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (41.86) | 18.7374 |
| 1990's | 9 (20.93) | 18.2507 |
| 2000's | 7 (16.28) | 29.6817 |
| 2010's | 8 (18.60) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Müller, P | 1 |
| Dietrich, JW | 1 |
| Lin, T | 1 |
| Bejinariu, A | 1 |
| Binnebößel, S | 1 |
| Bergen, F | 1 |
| Schmidt, J | 1 |
| Müller, SK | 1 |
| Chatzitomaris, A | 1 |
| Kurt, M | 1 |
| Gerguri, S | 1 |
| Clasen, L | 1 |
| Klein, HH | 1 |
| Kelm, M | 1 |
| Makimoto, H | 1 |
| Karavelioglu, Y | 1 |
| Baran, A | 1 |
| Karapinar, H | 1 |
| Küçükdurmaz, Z | 1 |
| Yilmaz, A | 1 |
| Yelve, K | 1 |
| Panandikar, GA | 1 |
| Pazare, A | 1 |
| Bajpai, S | 1 |
| Saad, NS | 1 |
| Floyd, K | 1 |
| Ahmed, AA | 1 |
| Mohler, PJ | 1 |
| Janssen, PM | 2 |
| Elnakish, MT | 2 |
| Ye, J | 1 |
| Zhong, X | 1 |
| Du, Y | 1 |
| Cai, C | 1 |
| Pan, T | 1 |
| Du, RH | 1 |
| Yi, HW | 1 |
| Dai, DZ | 4 |
| Tang, WH | 1 |
| Dai, Y | 4 |
| Su, L | 1 |
| Deng, W | 1 |
| Yin, YH | 1 |
| De Sanctis, V | 1 |
| Govoni, MR | 1 |
| Sprocati, M | 1 |
| Marsella, M | 1 |
| Conti, E | 1 |
| Flood, JA | 1 |
| Hoover, JP | 1 |
| Farmaki, K | 1 |
| Tzoumari, I | 1 |
| Pappa, C | 1 |
| Chouliaras, G | 1 |
| Berdoukas, V | 1 |
| Wang, J | 1 |
| Zhang, WD | 1 |
| Lin, MS | 1 |
| Zhai, QB | 1 |
| Yu, F | 1 |
| Kim, BH | 1 |
| Cho, KI | 1 |
| Kim, SM | 1 |
| Kim, JY | 1 |
| Choi, BG | 1 |
| Kang, JH | 1 |
| Jeon, YK | 1 |
| Kim, SS | 1 |
| Kim, SJ | 1 |
| Kim, YK | 1 |
| Kim, IJ | 1 |
| Hassona, MD | 1 |
| Alhaj, MA | 1 |
| Moldovan, L | 1 |
| Khan, M | 1 |
| Hassanain, HH | 1 |
| Burmeister, LA | 1 |
| Flores, A | 1 |
| Xia, HJ | 1 |
| Na, T | 1 |
| Huang, ZJ | 1 |
| Zhang, Y | 1 |
| Tapbergenov, SO | 1 |
| Koptelov, VA | 1 |
| Malhotra, A | 1 |
| Penpargkul, S | 1 |
| Fein, FS | 1 |
| Sonnenblick, EH | 1 |
| Scheuer, J | 1 |
| Chen, YY | 1 |
| Van Vleet, JF | 1 |
| Ferrans, VJ | 1 |
| Badylak, SF | 1 |
| Dietrich, A | 1 |
| Mortensen, ME | 1 |
| Wheller, J | 1 |
| Wajdowicz, A | 1 |
| Dabroś, W | 1 |
| Zaczek, M | 1 |
| Wu, HY | 1 |
| Xia, YM | 1 |
| Ha, PC | 1 |
| Chen, XS | 1 |
| Williams, SA | 1 |
| Tappia, PS | 1 |
| Yu, CH | 1 |
| Bibeau, M | 1 |
| Panagia, V | 1 |
| Goichot, B | 1 |
| Schlienger, JL | 1 |
| Hu, HJ | 1 |
| Shen, YM | 1 |
| Kitaeva, AP | 2 |
| Tedeeva, ZD | 2 |
| Kirsanov, NV | 1 |
| Karsanov, NV | 1 |
| Hegyvary, C | 1 |
| Cheng, FS | 1 |
| Kang, K | 1 |
| Ledvora, RF | 1 |
| Boyd, E | 1 |
| Siebers, G | 1 |
| Schicha, H | 1 |
| Becker, V | 1 |
| Vyska, K | 1 |
| Feinendegen, LE | 1 |
| Liu, SY | 1 |
| Wang, F | 1 |
| Schreiner, RD | 1 |
| Morgan, HJ | 1 |
| Stroev, EA | 1 |
| Stroitelev, VV | 1 |
| Astrakhantsev, AF | 1 |
| Galdiero, F | 1 |
| Tufano, MA | 1 |
| Rossi, F | 1 |
| Filippelli, W | 1 |
| De Santis, D | 1 |
| Matera, C | 1 |
| Berrino, L | 1 |
| Marmo, E | 1 |
| Noll, B | 1 |
| Göke, B | 1 |
| Willemer, S | 1 |
| Richter, G | 1 |
| Arnold, R | 1 |
| Shiomi, T | 1 |
| Yano, Y | 1 |
| Kobayashi, T | 1 |
| Watanabe, T | 1 |
| Kojima, H | 1 |
| Shenoy, MM | 1 |
| Goldman, JM | 1 |
| Cavallo, A | 1 |
| Casta, A | 1 |
| Fawcett, HD | 1 |
| Nusynowitz, ML | 1 |
| Wolf, WJ | 1 |
| Goldstein, MA | 1 |
| Mikulicich, GF | 1 |
| Oester, TY | 1 |
| Prange, AJ | 1 |
| Meek, JL | 1 |
| Lipton, MA | 1 |
| Weir, RJ | 1 |
| Young, JA | 1 |
| McGuinness, JB | 1 |
| Beznak, M | 1 |
| Korecky, B | 1 |
| Thomas, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Cardiopulmonary Resuscitation[NCT04392258] | 200 participants (Anticipated) | Observational | 2021-05-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thyroxine and Cardiomyopathies, Primary
| Article | Year |
|---|---|
Subclinical thyrotoxicosis and the heart.
Topics: Cardiomyopathies; Cardiovascular Physiological Phenomena; Exercise Tolerance; Hemodynamics; Humans; | 2002 |
[Non-thyroid indications of treatment with thyroid hormones].
Topics: Animals; Cardiac Surgical Procedures; Cardiomyopathies; Cardiovascular System; Clinical Trials as To | 1998 |
1 trial available for thyroxine and Cardiomyopathies, Primary
| Article | Year |
|---|---|
Normalisation of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassaemia major.
Topics: Adolescent; Adult; beta-Thalassemia; Blood Glucose; Cardiomyopathies; Child; Deferiprone; Deferoxami | 2010 |
40 other studies available for thyroxine and Cardiomyopathies, Primary
| Article | Year |
|---|---|
Usefulness of Serum Free Thyroxine Concentration to Predict Ventricular Arrhythmia Risk in Euthyroid Patients With Structural Heart Disease.
Topics: Aged; Cardiac Pacing, Artificial; Cardiomyopathies; Cohort Studies; Defibrillators, Implantable; Ele | 2020 |
Reversible cardiomyopathy associated with autoimmune polyendocrine syndrome type II.
Topics: Adult; Cardiomyopathies; Delayed Diagnosis; Female; Fludrocortisone; Hormone Replacement Therapy; Hu | 2013 |
Isolated right ventricular cardiomyopathy with autoimmune hypothyroidism: a rare association in an adolescent.
Topics: Acenocoumarol; Adolescent; Anti-Arrhythmia Agents; Anticoagulants; Cardiomyopathies; Digoxin; Diuret | 2015 |
The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities.
Topics: Animals; Blood Pressure; Cardiomyopathies; Disease Models, Animal; Echocardiography; Electrocardiogr | 2016 |
Role of levothyroxine and vitamin E supplementation in the treatment of oxidative stress-induced injury and apoptosis of myocardial cells in hypothyroid rats.
Topics: Animals; Antioxidants; Apoptosis; Cardiomyopathies; Dietary Supplements; Hypothyroidism; Male; Oxida | 2017 |
Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Aspartic Acid Endopeptidases; Berberine; Cardiomegaly | 2008 |
[Renin-angiotensin system blocking agents reverse the myocardial hypertrophy in experimental hyperthyroid cardiomyopathy via altering intracellular calcium handling].
Topics: Animals; Calcium; Calcium Channels; Cardiomyopathies; Disease Models, Animal; Hyperthyroidism; Imida | 2008 |
Cardiomyopathy and pericardial effusion in a 7 year-old boy with beta-thalassaemia major, severe primary hypothyroidism and hypoparathyroidism due to iron overload.
Topics: beta-Thalassemia; Calcium; Cardiomyopathies; Cardiotonic Agents; Child; Digoxin; Diuretics; Humans; | 2008 |
Improvement in myocardial dysfunction in a hypothyroid dog.
Topics: Animals; Cardiomyopathies; Dog Diseases; Dogs; Hypothyroidism; Male; Myxedema; Pleural Effusion; Thy | 2009 |
[Alterations of cardiac hemodynamics, sodium current and L-type calcium current in rats with L-thyroxine-induced cardiomyopathy].
Topics: Animals; Calcium Channels, L-Type; Cardiomyopathies; Hemodynamics; Male; Myocardium; Patch-Clamp Tec | 2010 |
Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Cardiomyopathies; Echocardiogr | 2012 |
Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis.
Topics: Animals; Apoptosis; Blotting, Western; Carbazoles; Cardiomegaly; Cardiomyopathies; Carvedilol; Echoc | 2012 |
Up-regulated inflammatory factors endothelin, NFkappaB, TNFalpha and iNOS involved in exaggerated cardiac arrhythmias in l-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelins; I | 2006 |
Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017.
Topics: Animals; Anti-Arrhythmia Agents; Aspartic Acid Endopeptidases; Berberine; Calcium; Cardiomyopathies; | 2007 |
[Adrenoreceptor-independent effect of thyroxine and adrenoxyl on myocardial adenyl cyclase activity and cAMP levels].
Topics: Adenylyl Cyclases; Adrenochrome; Animals; Cardiomyopathies; Cyclic AMP; Heart; Myocardium; Propranol | 1981 |
The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.
Topics: Adenosine Triphosphatases; Animals; Blood Glucose; Cardiomyopathies; Diabetes Mellitus, Experimental | 1981 |
[9 cases of myxedema heart].
Topics: Adolescent; Adult; Cardiomyopathies; Electrocardiography; Female; Humans; Male; Middle Aged; Myxedem | 1984 |
Effect of thyroid hormone supplementation on chronic doxorubicin (adriamycin)-induced cardiotoxicity and serum concentrations of T3 and T4 in dogs.
Topics: Alopecia; Animals; Cardiomyopathies; Dog Diseases; Dogs; Doxorubicin; Female; Heart; Melanosis; Myoc | 1982 |
Cardiac toxicity in an adolescent following chronic lithium and imipramine therapy.
Topics: Adolescent; Cardiac Complexes, Premature; Cardiomyopathies; Child; Child Behavior Disorders; Drug Th | 1993 |
Myocardial damage in thyrotoxicosis--ultrastructural studies.
Topics: Animals; Ascorbic Acid; Cardiomyopathies; Female; Free Radicals; Hyperthyroidism; Male; Microscopy, | 1996 |
Changes in myocardial thyroid hormone metabolism and alpha-glycerophosphate dehydrogenase activity in rats deficient in iodine and selenium.
Topics: Analysis of Variance; Animals; Cardiomyopathies; Energy Metabolism; Glycerolphosphate Dehydrogenase; | 1997 |
Impairment of the sarcolemmal phospholipase D-phosphatidate phosphohydrolase pathway in diabetic cardiomyopathy.
Topics: Animals; Cardiomyopathies; Diabetes Mellitus, Experimental; Diglycerides; Enzyme Inhibitors; Fluorid | 1998 |
Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs.
Topics: Animals; Cardiomyopathies; Coronary Circulation; Female; Guinea Pigs; Heart Rate; Histamine; In Vitr | 1997 |
[Thermodynamic parameters of melting and normalization of the structure of myocardial G-actin in normal conditions and during myocardial dystrophies].
Topics: Actins; Animals; Cardiomyopathies; Dogs; Male; Myocardium; Thermodynamics; Thyroid Gland; Thyroxine | 1999 |
[Effect of polymerization on thermodynamic parameters of melting and stabilization of myocardial F-actin structure in normal dogs and dogs with myocardiodystrophy].
Topics: Actins; Animals; Calorimetry, Differential Scanning; Cardiomyopathies; Dogs; Myocardium; Thermodynam | 1999 |
Diminished effects of L-thyroxine on some functions and enzymes of the heart in myopathic hamsters.
Topics: Adenylyl Cyclases; Animals; Cardiomyopathies; Cricetinae; Heart; Heart Rate; Male; Mesocricetus; Myo | 1979 |
[Minimal cardiac transit time in thyroid disorders and in the effort syndrome].
Topics: Adult; Blood Flow Velocity; Cardiomyopathies; Diagnosis, Differential; Female; Heart; Heart Failure; | 1975 |
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E.
Topics: Animals; Cardiomyopathies; Free Radicals; Glutathione; Glutathione Peroxidase; Iodide Peroxidase; Io | 1991 |
A reversible cardiomyopathy.
Topics: Aged; Cardiomyopathies; Humans; Hypothyroidism; Male; Thyroxine | 1989 |
[Effect of estrogens and thyroid hormones on the development of isoprenaline-induced myocardiodystrophy].
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiomyopathies; Cyclic AMP; Estradiol; Estrogens; Fe | 1988 |
Effect of Salmonella typhimurium porins on the cardiovascular and renal apparatus.
Topics: Animals; Bacterial Outer Membrane Proteins; Barium; Barium Compounds; Blood Pressure; Cardiomyopathi | 1986 |
Influence of experimental hyperthyroidism on blood and myocardial serotonin in rats.
Topics: Administration, Oral; Animals; Cardiomyopathies; Hyperthyroidism; Male; Myocardium; Rats; Rats, Inbr | 1988 |
[A case of myxedema of the heart with sleep apnea syndrome].
Topics: Cardiomyopathies; Electrocardiography; Humans; Male; Middle Aged; Monitoring, Physiologic; Myxedema; | 1988 |
Hypothyroid cardiomyopathy: echocardiographic documentation of reversibility.
Topics: Adult; Aged; Aged, 80 and over; Cardiomyopathies; Echocardiography; Female; Heart Septum; Heart Vent | 1987 |
Is there a thyrotoxic cardiomyopathy in children?
Topics: Adolescent; Blood Pressure; Cardiomyopathies; Child; Female; Heart Rate; Humans; Hyperthyroidism; Ma | 1985 |
Nuclear pores in ventricular muscle cells from adult hypertrophied hearts.
Topics: Animals; Aortic Valve Stenosis; Cardiomyopathies; Cell Nucleus; Cricetinae; Guinea Pigs; Heart; Micr | 1974 |
The inhibition of the epinephrine--thyroxin induced arteriosclerosis by phentolamine.
Topics: Animals; Aorta; Arteriosclerosis; Cardiomyopathies; Epinephrine; Injections, Intravenous; Injections | 1970 |
Catecholamines: diminished rate of synth- esis in rat brain and heart after thyroxine pretreatment.
Topics: Animals; Body Weight; Brain; Carbon Isotopes; Cardiomyopathies; Catecholamines; Dopamine; Heart; Mal | 1970 |
Changes in the electrocardiogram and achilles reflex test during treatment of hypothyroidism.
Topics: Achilles Tendon; Aged; Cardiomyopathies; Electrocardiography; Female; Heart Rate; Humans; Hypothyroi | 1969 |
Regression of cardiac hypertrophies of various origin.
Topics: Anemia, Hypochromic; Animals; Aortic Coarctation; Blood Pressure; Cardiomyopathies; Desoxycorticoste | 1969 |