Page last updated: 2024-11-07

thyroxine and Cardiomyopathies, Primary

thyroxine has been researched along with Cardiomyopathies, Primary in 43 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
" In 18 requiring thyroxine supplementation for hypothyroidism, 10 were able to discontinue, and four reduced their thyroxine dose."5.14Normalisation of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassaemia major. ( Berdoukas, V; Chouliaras, G; Farmaki, K; Pappa, C; Tzoumari, I, 2010)
"Subclinical thyrotoxicosis is defined as a below normal thyrotropin (TSH) in association with a normal total and free thyroxine (T4) and triiodothyronine (T3)."4.81Subclinical thyrotoxicosis and the heart. ( Burmeister, LA; Flores, A, 2002)
" A rat model of thyrotoxicosis was established by daily intraperitoneal injections of L-thyroxine (T(4), 100 μg/kg) for 4 weeks."3.78Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy. ( Cho, KI; Choi, BG; Jeon, YK; Kang, JH; Kim, BH; Kim, IJ; Kim, JY; Kim, SJ; Kim, SM; Kim, SS; Kim, YK, 2012)
" We hypothesized that CPU86017, derived from berberine, which possesses multi-channel blocking activity, could suppress inflammatory factors, resulting in inhibition of over-expression of ether-a-go-go (ERG) and an augmented incidence of ventricular fibrillation (VF) in ischaemia/reperfusion (I/R)."3.74Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent. ( Dai, DZ; Dai, Y; Du, RH; Tang, WH; Yi, HW, 2008)
" Imidapril and valsartan may exert beneficial effects on hyperthyroid myocardial hypertrophy via altering intracellular calcium handling."3.74[Renin-angiotensin system blocking agents reverse the myocardial hypertrophy in experimental hyperthyroid cardiomyopathy via altering intracellular calcium handling]. ( Dai, Y; Deng, W; Su, L; Yin, YH, 2008)
"A case report is presented of an adolescent male who developed hypothyroidism and cardiomyopathy 6 months after he began taking lithium and imipramine for a severe conduct disorder."3.68Cardiac toxicity in an adolescent following chronic lithium and imipramine therapy. ( Dietrich, A; Mortensen, ME; Wheller, J, 1993)
"In patients with effort syndrome and hyperthyroidism, MTTs were often, but not always shortened below the control values; consequently, in case of associated heart disease, MTT-prolongation may be masked in such instances where hyperthyroidism causes MTT shortening."1.25[Minimal cardiac transit time in thyroid disorders and in the effort syndrome]. ( Becker, V; Feinendegen, LE; Schicha, H; Siebers, G; Vyska, K, 1975)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199018 (41.86)18.7374
1990's9 (20.93)18.2507
2000's7 (16.28)29.6817
2010's8 (18.60)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Müller, P1
Dietrich, JW1
Lin, T1
Bejinariu, A1
Binnebößel, S1
Bergen, F1
Schmidt, J1
Müller, SK1
Chatzitomaris, A1
Kurt, M1
Gerguri, S1
Clasen, L1
Klein, HH1
Kelm, M1
Makimoto, H1
Karavelioglu, Y1
Baran, A1
Karapinar, H1
Küçükdurmaz, Z1
Yilmaz, A1
Yelve, K1
Panandikar, GA1
Pazare, A1
Bajpai, S1
Saad, NS1
Floyd, K1
Ahmed, AA1
Mohler, PJ1
Janssen, PM2
Elnakish, MT2
Ye, J1
Zhong, X1
Du, Y1
Cai, C1
Pan, T1
Du, RH1
Yi, HW1
Dai, DZ4
Tang, WH1
Dai, Y4
Su, L1
Deng, W1
Yin, YH1
De Sanctis, V1
Govoni, MR1
Sprocati, M1
Marsella, M1
Conti, E1
Flood, JA1
Hoover, JP1
Farmaki, K1
Tzoumari, I1
Pappa, C1
Chouliaras, G1
Berdoukas, V1
Wang, J1
Zhang, WD1
Lin, MS1
Zhai, QB1
Yu, F1
Kim, BH1
Cho, KI1
Kim, SM1
Kim, JY1
Choi, BG1
Kang, JH1
Jeon, YK1
Kim, SS1
Kim, SJ1
Kim, YK1
Kim, IJ1
Hassona, MD1
Alhaj, MA1
Moldovan, L1
Khan, M1
Hassanain, HH1
Burmeister, LA1
Flores, A1
Xia, HJ1
Na, T1
Huang, ZJ1
Zhang, Y1
Tapbergenov, SO1
Koptelov, VA1
Malhotra, A1
Penpargkul, S1
Fein, FS1
Sonnenblick, EH1
Scheuer, J1
Chen, YY1
Van Vleet, JF1
Ferrans, VJ1
Badylak, SF1
Dietrich, A1
Mortensen, ME1
Wheller, J1
Wajdowicz, A1
Dabroś, W1
Zaczek, M1
Wu, HY1
Xia, YM1
Ha, PC1
Chen, XS1
Williams, SA1
Tappia, PS1
Yu, CH1
Bibeau, M1
Panagia, V1
Goichot, B1
Schlienger, JL1
Hu, HJ1
Shen, YM1
Kitaeva, AP2
Tedeeva, ZD2
Kirsanov, NV1
Karsanov, NV1
Hegyvary, C1
Cheng, FS1
Kang, K1
Ledvora, RF1
Boyd, E1
Siebers, G1
Schicha, H1
Becker, V1
Vyska, K1
Feinendegen, LE1
Liu, SY1
Wang, F1
Schreiner, RD1
Morgan, HJ1
Stroev, EA1
Stroitelev, VV1
Astrakhantsev, AF1
Galdiero, F1
Tufano, MA1
Rossi, F1
Filippelli, W1
De Santis, D1
Matera, C1
Berrino, L1
Marmo, E1
Noll, B1
Göke, B1
Willemer, S1
Richter, G1
Arnold, R1
Shiomi, T1
Yano, Y1
Kobayashi, T1
Watanabe, T1
Kojima, H1
Shenoy, MM1
Goldman, JM1
Cavallo, A1
Casta, A1
Fawcett, HD1
Nusynowitz, ML1
Wolf, WJ1
Goldstein, MA1
Mikulicich, GF1
Oester, TY1
Prange, AJ1
Meek, JL1
Lipton, MA1
Weir, RJ1
Young, JA1
McGuinness, JB1
Beznak, M1
Korecky, B1
Thomas, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Cardiopulmonary Resuscitation[NCT04392258]200 participants (Anticipated)Observational2021-05-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for thyroxine and Cardiomyopathies, Primary

ArticleYear
Subclinical thyrotoxicosis and the heart.
    Thyroid : official journal of the American Thyroid Association, 2002, Volume: 12, Issue:6

    Topics: Cardiomyopathies; Cardiovascular Physiological Phenomena; Exercise Tolerance; Hemodynamics; Humans;

2002
[Non-thyroid indications of treatment with thyroid hormones].
    La Revue de medecine interne, 1998, Volume: 19, Issue:10

    Topics: Animals; Cardiac Surgical Procedures; Cardiomyopathies; Cardiovascular System; Clinical Trials as To

1998

Trials

1 trial available for thyroxine and Cardiomyopathies, Primary

ArticleYear
Normalisation of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassaemia major.
    British journal of haematology, 2010, Volume: 148, Issue:3

    Topics: Adolescent; Adult; beta-Thalassemia; Blood Glucose; Cardiomyopathies; Child; Deferiprone; Deferoxami

2010

Other Studies

40 other studies available for thyroxine and Cardiomyopathies, Primary

ArticleYear
Usefulness of Serum Free Thyroxine Concentration to Predict Ventricular Arrhythmia Risk in Euthyroid Patients With Structural Heart Disease.
    The American journal of cardiology, 2020, 04-15, Volume: 125, Issue:8

    Topics: Aged; Cardiac Pacing, Artificial; Cardiomyopathies; Cohort Studies; Defibrillators, Implantable; Ele

2020
Reversible cardiomyopathy associated with autoimmune polyendocrine syndrome type II.
    Internal medicine (Tokyo, Japan), 2013, Volume: 52, Issue:9

    Topics: Adult; Cardiomyopathies; Delayed Diagnosis; Female; Fludrocortisone; Hormone Replacement Therapy; Hu

2013
Isolated right ventricular cardiomyopathy with autoimmune hypothyroidism: a rare association in an adolescent.
    BMJ case reports, 2015, Mar-20, Volume: 2015

    Topics: Acenocoumarol; Adolescent; Anti-Arrhythmia Agents; Anticoagulants; Cardiomyopathies; Digoxin; Diuret

2015
The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Animals; Blood Pressure; Cardiomyopathies; Disease Models, Animal; Echocardiography; Electrocardiogr

2016
Role of levothyroxine and vitamin E supplementation in the treatment of oxidative stress-induced injury and apoptosis of myocardial cells in hypothyroid rats.
    Journal of endocrinological investigation, 2017, Volume: 40, Issue:7

    Topics: Animals; Antioxidants; Apoptosis; Cardiomyopathies; Dietary Supplements; Hypothyroidism; Male; Oxida

2017
Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:8

    Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Aspartic Acid Endopeptidases; Berberine; Cardiomegaly

2008
[Renin-angiotensin system blocking agents reverse the myocardial hypertrophy in experimental hyperthyroid cardiomyopathy via altering intracellular calcium handling].
    Zhonghua xin xue guan bing za zhi, 2008, Volume: 36, Issue:8

    Topics: Animals; Calcium; Calcium Channels; Cardiomyopathies; Disease Models, Animal; Hyperthyroidism; Imida

2008
Cardiomyopathy and pericardial effusion in a 7 year-old boy with beta-thalassaemia major, severe primary hypothyroidism and hypoparathyroidism due to iron overload.
    Pediatric endocrinology reviews : PER, 2008, Volume: 6 Suppl 1

    Topics: beta-Thalassemia; Calcium; Cardiomyopathies; Cardiotonic Agents; Child; Digoxin; Diuretics; Humans;

2008
Improvement in myocardial dysfunction in a hypothyroid dog.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2009, Volume: 50, Issue:8

    Topics: Animals; Cardiomyopathies; Dog Diseases; Dogs; Hypothyroidism; Male; Myxedema; Pleural Effusion; Thy

2009
[Alterations of cardiac hemodynamics, sodium current and L-type calcium current in rats with L-thyroxine-induced cardiomyopathy].
    Sheng li xue bao : [Acta physiologica Sinica], 2010, Aug-25, Volume: 62, Issue:4

    Topics: Animals; Calcium Channels, L-Type; Cardiomyopathies; Hemodynamics; Male; Myocardium; Patch-Clamp Tec

2010
Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy.
    Endocrine journal, 2012, Volume: 59, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Cardiomyopathies; Echocardiogr

2012
Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Animals; Apoptosis; Blotting, Western; Carbazoles; Cardiomegaly; Cardiomyopathies; Carvedilol; Echoc

2012
Up-regulated inflammatory factors endothelin, NFkappaB, TNFalpha and iNOS involved in exaggerated cardiac arrhythmias in l-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats.
    Life sciences, 2006, Oct-04, Volume: 79, Issue:19

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelins; I

2006
Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:6

    Topics: Animals; Anti-Arrhythmia Agents; Aspartic Acid Endopeptidases; Berberine; Calcium; Cardiomyopathies;

2007
[Adrenoreceptor-independent effect of thyroxine and adrenoxyl on myocardial adenyl cyclase activity and cAMP levels].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 91, Issue:4

    Topics: Adenylyl Cyclases; Adrenochrome; Animals; Cardiomyopathies; Cyclic AMP; Heart; Myocardium; Propranol

1981
The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.
    Circulation research, 1981, Volume: 49, Issue:6

    Topics: Adenosine Triphosphatases; Animals; Blood Glucose; Cardiomyopathies; Diabetes Mellitus, Experimental

1981
[9 cases of myxedema heart].
    Zhonghua xin xue guan bing za zhi, 1984, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Cardiomyopathies; Electrocardiography; Female; Humans; Male; Middle Aged; Myxedem

1984
Effect of thyroid hormone supplementation on chronic doxorubicin (adriamycin)-induced cardiotoxicity and serum concentrations of T3 and T4 in dogs.
    American journal of veterinary research, 1982, Volume: 43, Issue:12

    Topics: Alopecia; Animals; Cardiomyopathies; Dog Diseases; Dogs; Doxorubicin; Female; Heart; Melanosis; Myoc

1982
Cardiac toxicity in an adolescent following chronic lithium and imipramine therapy.
    The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 1993, Volume: 14, Issue:5

    Topics: Adolescent; Cardiac Complexes, Premature; Cardiomyopathies; Child; Child Behavior Disorders; Drug Th

1993
Myocardial damage in thyrotoxicosis--ultrastructural studies.
    Polish journal of pathology : official journal of the Polish Society of Pathologists, 1996, Volume: 47, Issue:3

    Topics: Animals; Ascorbic Acid; Cardiomyopathies; Female; Free Radicals; Hyperthyroidism; Male; Microscopy,

1996
Changes in myocardial thyroid hormone metabolism and alpha-glycerophosphate dehydrogenase activity in rats deficient in iodine and selenium.
    The British journal of nutrition, 1997, Volume: 78, Issue:4

    Topics: Analysis of Variance; Animals; Cardiomyopathies; Energy Metabolism; Glycerolphosphate Dehydrogenase;

1997
Impairment of the sarcolemmal phospholipase D-phosphatidate phosphohydrolase pathway in diabetic cardiomyopathy.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:1

    Topics: Animals; Cardiomyopathies; Diabetes Mellitus, Experimental; Diglycerides; Enzyme Inhibitors; Fluorid

1998
Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:2

    Topics: Animals; Cardiomyopathies; Coronary Circulation; Female; Guinea Pigs; Heart Rate; Histamine; In Vitr

1997
[Thermodynamic parameters of melting and normalization of the structure of myocardial G-actin in normal conditions and during myocardial dystrophies].
    Biulleten' eksperimental'noi biologii i meditsiny, 1999, Volume: 128, Issue:7

    Topics: Actins; Animals; Cardiomyopathies; Dogs; Male; Myocardium; Thermodynamics; Thyroid Gland; Thyroxine

1999
[Effect of polymerization on thermodynamic parameters of melting and stabilization of myocardial F-actin structure in normal dogs and dogs with myocardiodystrophy].
    Biulleten' eksperimental'noi biologii i meditsiny, 1999, Volume: 127, Issue:8

    Topics: Actins; Animals; Calorimetry, Differential Scanning; Cardiomyopathies; Dogs; Myocardium; Thermodynam

1999
Diminished effects of L-thyroxine on some functions and enzymes of the heart in myopathic hamsters.
    Journal of molecular and cellular cardiology, 1979, Volume: 11, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cardiomyopathies; Cricetinae; Heart; Heart Rate; Male; Mesocricetus; Myo

1979
[Minimal cardiac transit time in thyroid disorders and in the effort syndrome].
    Nuclear-Medizin, 1975, Mar-31, Volume: 14, Issue:1

    Topics: Adult; Blood Flow Velocity; Cardiomyopathies; Diagnosis, Differential; Female; Heart; Heart Failure;

1975
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E.
    Biomedical and environmental sciences : BES, 1991, Volume: 4, Issue:4

    Topics: Animals; Cardiomyopathies; Free Radicals; Glutathione; Glutathione Peroxidase; Iodide Peroxidase; Io

1991
A reversible cardiomyopathy.
    Journal of the Tennessee Medical Association, 1989, Volume: 82, Issue:9

    Topics: Aged; Cardiomyopathies; Humans; Hypothyroidism; Male; Thyroxine

1989
[Effect of estrogens and thyroid hormones on the development of isoprenaline-induced myocardiodystrophy].
    Kardiologiia, 1988, Volume: 28, Issue:8

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiomyopathies; Cyclic AMP; Estradiol; Estrogens; Fe

1988
Effect of Salmonella typhimurium porins on the cardiovascular and renal apparatus.
    Journal of medicine, 1986, Volume: 17, Issue:5-6

    Topics: Animals; Bacterial Outer Membrane Proteins; Barium; Barium Compounds; Blood Pressure; Cardiomyopathi

1986
Influence of experimental hyperthyroidism on blood and myocardial serotonin in rats.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1988, Volume: 188, Issue:6

    Topics: Administration, Oral; Animals; Cardiomyopathies; Hyperthyroidism; Male; Myocardium; Rats; Rats, Inbr

1988
[A case of myxedema of the heart with sleep apnea syndrome].
    Kokyu to junkan. Respiration & circulation, 1988, Volume: 36, Issue:9

    Topics: Cardiomyopathies; Electrocardiography; Humans; Male; Middle Aged; Monitoring, Physiologic; Myxedema;

1988
Hypothyroid cardiomyopathy: echocardiographic documentation of reversibility.
    The American journal of the medical sciences, 1987, Volume: 294, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Cardiomyopathies; Echocardiography; Female; Heart Septum; Heart Vent

1987
Is there a thyrotoxic cardiomyopathy in children?
    The Journal of pediatrics, 1985, Volume: 107, Issue:4

    Topics: Adolescent; Blood Pressure; Cardiomyopathies; Child; Female; Heart Rate; Humans; Hyperthyroidism; Ma

1985
Nuclear pores in ventricular muscle cells from adult hypertrophied hearts.
    Journal of molecular and cellular cardiology, 1974, Volume: 6, Issue:3

    Topics: Animals; Aortic Valve Stenosis; Cardiomyopathies; Cell Nucleus; Cricetinae; Guinea Pigs; Heart; Micr

1974
The inhibition of the epinephrine--thyroxin induced arteriosclerosis by phentolamine.
    Angiology, 1970, Volume: 21, Issue:7

    Topics: Animals; Aorta; Arteriosclerosis; Cardiomyopathies; Epinephrine; Injections, Intravenous; Injections

1970
Catecholamines: diminished rate of synth- esis in rat brain and heart after thyroxine pretreatment.
    Life sciences. Pt. 1: Physiology and pharmacology, 1970, Aug-15, Volume: 9, Issue:16

    Topics: Animals; Body Weight; Brain; Carbon Isotopes; Cardiomyopathies; Catecholamines; Dopamine; Heart; Mal

1970
Changes in the electrocardiogram and achilles reflex test during treatment of hypothyroidism.
    Scottish medical journal, 1969, Volume: 14, Issue:2

    Topics: Achilles Tendon; Aged; Cardiomyopathies; Electrocardiography; Female; Heart Rate; Humans; Hypothyroi

1969
Regression of cardiac hypertrophies of various origin.
    Canadian journal of physiology and pharmacology, 1969, Volume: 47, Issue:7

    Topics: Anemia, Hypochromic; Animals; Aortic Coarctation; Blood Pressure; Cardiomyopathies; Desoxycorticoste

1969