thyroxine and Cardiomegaly studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

Excerpt	Relevance	Reference
" Sacubitril/valsartan (LCZ696) is a new combined drug that has shown promise for the treatment of hyperthyroidism-associated heart failure; however, the underlying molecular mechanisms, including the contributions of epigenetic regulation, remain unclear."	8.12	Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways. ( Abdullah, DM; Alsemeh, AE; Khamis, T, 2022)
" Type 2 Angiotensin II receptors (AT2R) are shown to be upregulated in cardiac hypertrophy observed in hyperthyroidism and this receptor has been reported to mediate cardioprotection against ischemic injury."	7.79	Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion. ( Barreto-Chaves, ML; da Silva, IB; Gomes, DA; Tavares, FM, 2013)
" The purpose of the present study was to evaluate differences in the AMP-activated protein kinase (AMPK) phosphorylation sites in cardiac hypertrophy induced by L-thyroxine and angiotensin (Ang) II."	7.76	A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II. ( Jiang, SY; Ma, XW; Xiao, H; Xu, M; Zhang, YY, 2010)
"Thyroxine can cause cardiac hypertrophy by activating growth factors, such as IGF-I (insulin-like growth factor-I)."	7.74	Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine. ( Araujo, AS; Belló-Klein, A; Enzveiler, AT; Fernandes, TR; Llesuy, S; Partata, WA; Ribeiro, MF; Schenkel, P, 2007)
"The present study assessed the possible involvement of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) in thyroxine (T4)-induced cardiac hypertrophy."	7.72	Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling. ( Barreto-Chaves, ML; Benvenuti, LA; Carneiro-Ramos, MS; Hu, LW; Liberti, EA, 2003)
"To assess the effects of berberine on cardiac hypertrophy induceded by L-thyroxine(L-Thy) in rats."	7.72	[Protective effect of berberine on cardiac hypertrophy induced by L-thyroxine in rats]. ( Xu, JG; Yang, J; Zhou, ZY, 2004)
" The aim of the present study was to evaluate whether the vascular response to potassium chloride and phenylephrine is abnormal in a rat model of thyroxine-induced cardiac hypertrophy."	7.71	Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats. ( Asimakopoulos, P; Carageorgiou, H; Cokkinos, DD; Cokkinos, DV; Giannakakis, S; Malliopoulou, V; Mourouzis, I; Pantos, CI; Tzeis, SM; Tzilalis, V; Varonos, DD, 2001)
"Cross sectional study of patients prescribed thyroxine long term (n = 11), patients with thyrotoxicosis studied at presentation (n = 23), compared with controls (n = 25); longitudinal study of patients with thyrotoxicosis studied at presentation and serially after beginning antithyroid drug treatment (n = 23)."	7.69	Cardiac hypertrophy as a result of long-term thyroxine therapy and thyrotoxicosis. ( Ching, GW; Daykin, J; Franklyn, JA; Gammage, MD; Sheppard, MC; Stallard, TJ, 1996)
"To study the effects of propranolol and bepridil on levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation."	7.69	Propranolol and bepridil attenuating levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation. ( Chen, DD; Dai, DZ; Lu, J; Zhang, XK, 1996)
"Levothyroxine-induced heart hypertrophy is a suitable model for severe ischemia and arrhythmias in rats."	7.69	Heart hypertrophy induced by levothyroxine aggravates ischemic lesions and reperfusion arrhythmias in rats. ( An, LF; Dai, DZ; Guo, XF; Yu, F, 1997)
"The goal of this paper was to determine the effects of 3,5,3'-triiodothyronine (T3)-thyroxine-induced cardiac hypertrophy on the rates of synthesis of mitochondrial proteins by both the cytoplasmic and mitochondrial protein synthesis systems and to compare the results with total protein synthesis and cardiac enlargement."	7.68	Mitochondrial protein synthesis during thyroxine-induced cardiac hypertrophy. ( Leung, AC; McKee, EE, 1990)
"In the present study the effect of thyroxine treatment on the development of cardiomegaly was compared in young (10-day-old) and adult (12-week-old) rats."	7.67	Thyroxine-induced cardiomegaly in rats of different age. ( Mares, V; Ostádal, B; Wachtlová, M, 1985)
"Thyroxine (T4) administered to rats in a dose of 1 mg/kg for 12 days induces cardiac hypertrophy."	7.67	Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat. ( Nosztray, K; Szabó, J; Szegi, J; Takács, IE, 1986)
"Cardiac hypertrophy was induced in rats by daily injections of L-thyroxine (1."	7.66	Synthesis and degradation of myocardial protein during the development and regression of thyroxine-induced cardiac hypertrophy in rats. ( Griffin, EE; Sanford, CF; Wildenthal, K, 1978)
"To determine whether development and regression of cardiac hypertrophy are accompanied by changes in heart volume and to learn whether a change in heart volume is associated with changes in the myocardial connective tissue, cardiac hypertrophy was induced in rats by administration of thyroxine."	7.65	Heart volume and myocardial connective tissue during development and regression of thyroxine-induced cardiac hypertrophy in rats. ( Edgren, J; Lindy, S; Turto, H; von Knorring, J, 1976)
"Hydrogen treatment also reduced the levothyroxine-induced increase in cardiac malondialdehyde, 8-hydroxy-2-deoxyguanosine and serum hydrogen peroxide levels and upregulated superoxide dismutase and glutathione peroxidase activity."	5.72	Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress. ( Bai, J; Chi, J; Gao, Y; Liu, J; Liu, S; Lv, Y; Yang, H; Yang, W; Yang, X; Zhan, C; Zhong, L, 2022)
"Here, cardiac hypertrophy was induced by injection of l-thyroxine or ISO in SD rats."	5.51	AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway. ( Hu, X; Li, T; Liu, J; Ou-Yang, Q; Wang, L; Xie, X, 2019)
"These data indicate that the cardiac hypertrophy induced by acute treatment with thyroid hormone precedes the angiogenic process, which probably occurs later."	5.33	Early cardiac hypertrophy induced by thyroxine is accompanied by an increase in VEGF-A expression but not by an increase in capillary density. ( Anjos-Ramos, L; Barreto-Chaves, ML; Carneiro-Ramos, MS; Diniz, GP; Martins-Silva, J, 2006)
"We conclude that in this model of cardiac hypertrophy 1) coronary vessel growth parallels the increase in ventricular mass, 2) capillaries grow by proliferation and an increase in diameter, and 3) vascular growth is not notably compromised during senescence."	5.29	Compensated coronary microvascular growth in senescent rats with thyroxine-induced cardiac hypertrophy. ( Butters, CA; Connell, PM; Tomanek, RJ; Torry, RJ, 1995)
"Pretreatment with colchicine did not affect the ability of L-thyroxine to induce cardiac hypertrophy but prevented its effects on both beta- and alpha 1-adrenoceptors."	5.28	Disparate effects of colchicine on thyroxine-induced cardiac hypertrophy and adrenoceptor changes. ( Limas, C; Limas, CJ, 1991)
" IPR administered to euthyroid rats in a dosage of 5 mg/kg/day for 4 days induced cardiomegaly."	5.27	Study of the factors influencing cardiac growth. I. Comparison of cardiomegaly induced by isoproterenol in euthyroid and thyroidectomized rats. ( Nosztray, K; Szabó, J; Szegi, J; Takács, IE, 1984)
" Sacubitril/valsartan (LCZ696) is a new combined drug that has shown promise for the treatment of hyperthyroidism-associated heart failure; however, the underlying molecular mechanisms, including the contributions of epigenetic regulation, remain unclear."	4.12	Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways. ( Abdullah, DM; Alsemeh, AE; Khamis, T, 2022)
" Effects included increased serum thyroxine levels and reduced hepatic carboxylesterease activity in dams, and advanced female puberty, weight gain, male cardiac hypertrophy, and altered exploratory behaviors in offspring."	3.79	Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. ( Belcher, SM; Braun, J; Gear, RB; Mabrey, N; McCaffrey, KA; Patisaul, HB; Roberts, SC; Stapleton, HM, 2013)
" Type 2 Angiotensin II receptors (AT2R) are shown to be upregulated in cardiac hypertrophy observed in hyperthyroidism and this receptor has been reported to mediate cardioprotection against ischemic injury."	3.79	Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion. ( Barreto-Chaves, ML; da Silva, IB; Gomes, DA; Tavares, FM, 2013)
"In this study, the role of the RhoA/Rho-kinase (RhoA/ROCK)-signaling pathway in cardiovascular dysfunction associated with hyperthyroidism was examined with the use of fasudil, a Rho-kinase inhibitor."	3.78	RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism. ( Jianping, Z; Li, C; Na, W; Peng, G; Shengjiang, G; Yanzhong, C, 2012)
" The purpose of the present study was to evaluate differences in the AMP-activated protein kinase (AMPK) phosphorylation sites in cardiac hypertrophy induced by L-thyroxine and angiotensin (Ang) II."	3.76	A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II. ( Jiang, SY; Ma, XW; Xiao, H; Xu, M; Zhang, YY, 2010)
" We hypothesized that CPU86017, derived from berberine, which possesses multi-channel blocking activity, could suppress inflammatory factors, resulting in inhibition of over-expression of ether-a-go-go (ERG) and an augmented incidence of ventricular fibrillation (VF) in ischaemia/reperfusion (I/R)."	3.74	Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent. ( Dai, DZ; Dai, Y; Du, RH; Tang, WH; Yi, HW, 2008)
"Thyroxine can cause cardiac hypertrophy by activating growth factors, such as IGF-I (insulin-like growth factor-I)."	3.74	Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine. ( Araujo, AS; Belló-Klein, A; Enzveiler, AT; Fernandes, TR; Llesuy, S; Partata, WA; Ribeiro, MF; Schenkel, P, 2007)
"This study aimed to quantify the effect of cardiac hypertrophy induced with isoprenaline and caffeine on reflex regulation of renal sympathetic nerve activity by the arterial and cardiopulmonary baroreceptors."	3.74	Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats. ( Aherne, CM; Buckley, MM; Flanagan, ET; Johns, EJ; Lainis, F; Sattar, M, 2008)
"The present study assessed the possible involvement of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) in thyroxine (T4)-induced cardiac hypertrophy."	3.72	Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling. ( Barreto-Chaves, ML; Benvenuti, LA; Carneiro-Ramos, MS; Hu, LW; Liberti, EA, 2003)
"Both RyR2 and SERCA mRNA level in L-thyroxin-induced cardiac hypertrophy was over-expressed and propranolol or verapamil inhibited the alteration."	3.72	Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy. ( Dai, DZ; Gao, F; Wu, XD; Zhang, QP, 2004)
"To assess the effects of berberine on cardiac hypertrophy induceded by L-thyroxine(L-Thy) in rats."	3.72	[Protective effect of berberine on cardiac hypertrophy induced by L-thyroxine in rats]. ( Xu, JG; Yang, J; Zhou, ZY, 2004)
" The aim of the present study was to evaluate whether the vascular response to potassium chloride and phenylephrine is abnormal in a rat model of thyroxine-induced cardiac hypertrophy."	3.71	Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats. ( Asimakopoulos, P; Carageorgiou, H; Cokkinos, DD; Cokkinos, DV; Giannakakis, S; Malliopoulou, V; Mourouzis, I; Pantos, CI; Tzeis, SM; Tzilalis, V; Varonos, DD, 2001)
"Patients with differentiated thyroid carcinoma (DTC) receive a life time l-thyroxine therapy in suppressive doses and may exhibit signs of cardiac hypertrophy."	3.71	[Effects of L-thyroxine suppressive therapy on cardiac mass in patients with differentiated thyroid cancer]. ( Czernik, E; Gubała, E; Jarzab, B; Kowalczyk, P; Matuszewska, G; Nowak, J; Roskosz, J; Sielańczyk, A, 2001)
" We investigated the influence of hyperthyroid state on the expression and functional properties of the ryanodine receptor (RyR), a major protein in the junctional SR (JSR), which mediates Ca(2+) release to trigger muscle contraction."	3.70	Thyroid hormone-induced overexpression of functional ryanodine receptors in the rabbit heart. ( Jiang, M; Narayanan, N; Tokmakejian, S; Xu, A, 2000)
"Thyroxine treatment was sufficient to induce a significant degree of tachycardia (423+/-6 vs 353+/-4 bpm, P < 0."	3.70	Autonomic contribution to the blood pressure and heart rate variability changes in early experimental hyperthyroidism. ( Elghozi, JL; Laude, D; Ponchon, P; Safa-Tisseront, V, 1998)
"Cross sectional study of patients prescribed thyroxine long term (n = 11), patients with thyrotoxicosis studied at presentation (n = 23), compared with controls (n = 25); longitudinal study of patients with thyrotoxicosis studied at presentation and serially after beginning antithyroid drug treatment (n = 23)."	3.69	Cardiac hypertrophy as a result of long-term thyroxine therapy and thyrotoxicosis. ( Ching, GW; Daykin, J; Franklyn, JA; Gammage, MD; Sheppard, MC; Stallard, TJ, 1996)
"Levothyroxine-induced heart hypertrophy is a suitable model for severe ischemia and arrhythmias in rats."	3.69	Heart hypertrophy induced by levothyroxine aggravates ischemic lesions and reperfusion arrhythmias in rats. ( An, LF; Dai, DZ; Guo, XF; Yu, F, 1997)
"To study the effects of propranolol and bepridil on levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation."	3.69	Propranolol and bepridil attenuating levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation. ( Chen, DD; Dai, DZ; Lu, J; Zhang, XK, 1996)
"The goal of this paper was to determine the effects of 3,5,3'-triiodothyronine (T3)-thyroxine-induced cardiac hypertrophy on the rates of synthesis of mitochondrial proteins by both the cytoplasmic and mitochondrial protein synthesis systems and to compare the results with total protein synthesis and cardiac enlargement."	3.68	Mitochondrial protein synthesis during thyroxine-induced cardiac hypertrophy. ( Leung, AC; McKee, EE, 1990)
"Two experimental models of cardiac hypertrophy (chronic thyroxine or isoprenaline treatment of adult rats) were compared 24 h and five weeks after the agent was last given."	3.68	Functional changes in the right and left ventricle during development of cardiac hypertrophy and after its regression. ( Cihák, R; Kolár, F; Ostádal, B; Pelouch, V; Procházka, J; Widimský, J, 1992)
"Thyroxine (T4) administered to rats in a dose of 1 mg/kg for 12 days induces cardiac hypertrophy."	3.67	Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat. ( Nosztray, K; Szabó, J; Szegi, J; Takács, IE, 1986)
" During daily injection of l-thyroxine, cardiac hypertrophy developed within 4 days and remained unchanged thereafter."	3.67	Influence of thyroid status on intracellular distribution of cardiac adrenoceptors. ( Limas, C; Limas, CJ, 1987)
"In the present study the effect of thyroxine treatment on the development of cardiomegaly was compared in young (10-day-old) and adult (12-week-old) rats."	3.67	Thyroxine-induced cardiomegaly in rats of different age. ( Mares, V; Ostádal, B; Wachtlová, M, 1985)
"By use of a combined morphologic, immunocytochemical, and biochemical approach, this study demonstrates the changes in the lysosomal vacuolar apparatus that accompany thyroxine-induced cardiac hypertrophy."	3.67	Lysosomal changes during thyroxine-induced left ventricular hypertrophy in rabbits. ( Decker, ML; Decker, RS; Lesch, M; Parmacek, MS; Samarel, AM, 1986)
"Administration of L-thyroxine (1 mg/kg) to adult rats results in cardiac hypertrophy and enhanced contractility."	3.66	Increased phospholipid methylation in the myocardium of hyperthyroid rats. ( Limas, CJ, 1980)
"Cardiac hypertrophy was induced in rabbits by subcutaneous injection of thyroxine or isoprenaline or by surgically constricting the abdominal aorta."	3.66	Metabolism of lipids in experimental hypertrophic hearts of rabbits. ( Cameron, AJ; Revis, NW, 1979)
"Cardiac hypertrophy was induced in rats by daily injections of L-thyroxine (1."	3.66	Synthesis and degradation of myocardial protein during the development and regression of thyroxine-induced cardiac hypertrophy in rats. ( Griffin, EE; Sanford, CF; Wildenthal, K, 1978)
"Cardiac hypertrophy, induced by pressure overload, leads to a depression in the rate of force development, velocity of shortening, tension-dependent heat generation, and myosin ATPase activity, whereas cardiac hypertrophy, induced by thyroxine administration, leads to an increase in these parameters."	3.66	Altered myosin isozyme patterns from pressure-overloaded and thyrotoxic hypertrophied rabbit hearts. ( Alpert, NR; Litten, RZ; Low, RB; Martin, BJ, 1982)
"Cardiac hypertrophy was induced in rabbits by injecting either thyroxine or isoprenaline or by surgically constricting the abdominal aorta."	3.66	The relationship between fibrosis and lactate dehydrogenase isoenzymes in the experimental hypertrophic heart of rabbits. ( Cameron, AJ; Revis, NW, 1978)
" Cardiomegaly has been produced in rats by sideropenic anaemia, by isoprenaline or thyroxine or by the application of both drugs, by artificial increase in resistance to blood flow and by long-term adaptation to hypoxia and physical stress."	3.65	The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly. ( Bartosová, D; Chvapil, M; Korecký, B; Poupa, O; Rakusan, K; Turek, Z; Vízek, M, 1969)
"To determine whether development and regression of cardiac hypertrophy are accompanied by changes in heart volume and to learn whether a change in heart volume is associated with changes in the myocardial connective tissue, cardiac hypertrophy was induced in rats by administration of thyroxine."	3.65	Heart volume and myocardial connective tissue during development and regression of thyroxine-induced cardiac hypertrophy in rats. ( Edgren, J; Lindy, S; Turto, H; von Knorring, J, 1976)
"Based on these findings, the observed congestive heart failure was considered as a sequel of myocardial injury caused by uncontrolled hyperthyroidism."	1.91	Heart failure in a cat due to hypertrophic cardiomyopathy phenotype caused by chronic uncontrolled hyperthyroidism. ( Chae, Y; Kang, BT; Kim, H; Koo, Y; Lee, D; Lee, H; Park, J; Yang, MP; Yun, T, 2023)
"Hyperthyroidism is not associated with radiographic pulmonary hyperinflation and is an unlikely differential for this radiographic finding."	1.72	Association between feline hyperthyroidism and thoracic radiographic evaluation of cardiomegaly and pulmonary hyperinflation. ( Marolf, AJ; Rao, S; Shropshire, SB; Young, V, 2022)
"Hydrogen treatment also reduced the levothyroxine-induced increase in cardiac malondialdehyde, 8-hydroxy-2-deoxyguanosine and serum hydrogen peroxide levels and upregulated superoxide dismutase and glutathione peroxidase activity."	1.72	Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress. ( Bai, J; Chi, J; Gao, Y; Liu, J; Liu, S; Lv, Y; Yang, H; Yang, W; Yang, X; Zhan, C; Zhong, L, 2022)
"Here, cardiac hypertrophy was induced by injection of l-thyroxine or ISO in SD rats."	1.51	AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway. ( Hu, X; Li, T; Liu, J; Ou-Yang, Q; Wang, L; Xie, X, 2019)
"Hyperthyroidism was confirmed by evaluation of T3 and T4 levels, as well as cardiac hypertrophy development."	1.48	Decreased PGC1- α levels and increased apoptotic protein signaling are associated with the maladaptive cardiac hypertrophy in hyperthyroidism. ( Araujo, ASDR; Barboza, TE; Bello-Klein, A; Bonetto, JHP; Carraro, CC; DE Araujo, CC; DE Castro, AL; DE Lima-Seolin, BG; Singal, PK; Siqueira, R; Teixeira, RB, 2018)
" This is a significant limitation because sustained changes in blood pressure are often accompanied by changes in heart rate and together can lead to cardiac hypertrophy and myocardial degeneration in animals, and major adverse cardiovascular events (MACE) in humans."	1.43	Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight. ( Engle, SK; Watson, DE, 2016)
"A transient model for human Graves' disease was successfully established in mice using up to 3 immunizations with recombinant adenovirus expressing the extracellular A-subunit of the human TSH receptor (TSHR) (Ad-TSHR)."	1.42	Prolonged TSH receptor A subunit immunization of female mice leads to a long-term model of Graves' disease, tachycardia, and cardiac hypertrophy. ( Faßbender, J; Goebel, S; Holthoff, HP; Li, Z; Lohse, MJ; Münch, G; Reimann, A; Ungerer, M; Zeibig, S, 2015)
"Maternal hyperthyroidism is associated with alterations in fetal development and altered pattern of expression in RAS components, which in addition to cardiac hypertrophy observed on GD20 may represent an important predisposing factor to cardiovascular diseases in adult life."	1.40	Maternal hyperthyroidism alters the pattern of expression of cardiac renin-angiotensin system components in rat offspring. ( Barreto-Chaves, ML; Lino, CA; Shibata, CE, 2014)
": Development of cardiac hypertrophy after thyroxin (T4) treatment is well recognized."	1.39	Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles. ( Elnakish, MT; Hassanain, HH; Janssen, PM; Khan, M; Moldovan, L, 2013)
"Myxedema coma (MC) is a rare, but often fatal endocrine emergency."	1.37	A case of myxedema coma caused by isolated thyrotropin stimulating hormone deficiency and Hashimoto's thyroiditis. ( Chihara, K; Hino, Y; Iida, K; Ohara, T, 2011)
"Hyperthyroidism was induced by T(4) administration (12 mg/l in drinking water for 28 days)."	1.35	The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism. ( Araujo, AS; Belló-Klein, A; Enzveiler, AT; Fernandes, TR; Khaper, N; Llesuy, S; Partata, WA; Ribeiro, MF; Schenkel, P; Singal, PK, 2008)
"Sodium houttuyfonate can inhibit myocardial hypertrophy in mouse and rat models by restricting the activity of the sympathetic nervous system and decreasing the levels of angiotensin II and endothelin-1 in ventricular tissue."	1.35	Effect of sodium houttuyfonate on myocardial hypertrophy in mice and rats. ( Chen, CX; Gao, JP; Gu, WL; Lü, J; Wang, Y, 2009)
"Induction of cardiac hypertrophy revealed a marked protective effect caused by the expression of the kallikrein transgene, evidenced by the significantly reduced cardiac weight gain and the lower enhancement in the cardiac expression of atrial natriuretic peptide and collagen III, markers for hypertrophy and fibrosis, respectively."	1.35	Protective actions of human tissue kallikrein gene in transgenic rat hearts. ( Bader, M; Nascimento, JW; Pesquero, JB; Silva, JA; Silva, MR, 2008)
"Although THs induce cardiac hypertrophy, the mechanism through which they exert this effect is unknown."	1.34	Rapamycin prevents thyroid hormone-induced cardiac hypertrophy. ( Gerdes, AM; Kuzman, JA; O'Connell, TD, 2007)
"Cardiac hypertrophy was evident in AMI hearts after 13 weeks but not at 2 weeks."	1.34	Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. ( Cokkinos, DV; Dimopoulos, A; Kokkinos, AD; Kostopanagiotou, G; Markakis, K; Mourouzis, I; Panagiotou, M; Pantos, C; Saranteas, T; Xinaris, C, 2007)
"Despite cardiac hypertrophy development, there is no ultrastructural evidence of myocardial degeneration."	1.33	Myocardial ultrastructure in cardiac hypertrophy induced by thyroid hormone--an acute study in rats. ( Barreto-Chaves, ML; Hu, LW; Liberti, EA, 2005)
"These data indicate that the cardiac hypertrophy induced by acute treatment with thyroid hormone precedes the angiogenic process, which probably occurs later."	1.33	Early cardiac hypertrophy induced by thyroxine is accompanied by an increase in VEGF-A expression but not by an increase in capillary density. ( Anjos-Ramos, L; Barreto-Chaves, ML; Carneiro-Ramos, MS; Diniz, GP; Martins-Silva, J, 2006)
"Thyroid hormone induces cardiac hypertrophy and preconditions the myocardium against ischemia reperfusion injury."	1.33	Blockade of angiotensin II type 1 receptor diminishes cardiac hypertrophy, but does not abolish thyroxin-induced preconditioning. ( Cokkinos, DV; Karageorgiou, H; Karamanoli, E; Moraitis, P; Mourouzis, C; Mourouzis, I; Paizis, I; Pantos, C; Tzeis, S, 2005)
"Hyperthyroidism causes physiological cardiac hypertrophy and enhanced function."	1.33	L-Thyroxine activates Akt signaling in the heart. ( Gerdes, AM; Kuzman, JA; Thomas, TA; Vogelsang, KA, 2005)
"Thyrotoxicosis was produced by a daily intraperitoneal (i."	1.31	[Contribution of the renin-angiotensin system to blood pressure variability in hyperthyroid rats]. ( Basset, A; Blanc, J; Elghozi, JL, 2000)
"Thyroid hormone-induced cardiac hypertrophy is a model of enhanced physiological growth and angiogenesis."	1.30	Coordinated capillary and myocardial growth in response to thyroxine treatment. ( Busch, TL; Tomanek, RJ, 1998)
"Appropriate cardiac hypertrophy (CH) is necessary in several clinical settings, such as pulmonary artery banding in the two-stage arterial switch operation for transposition of the great arteries."	1.30	Pharmacological modulation of pressure-overload cardiac hypertrophy: changes in ventricular function, extracellular matrix, and gene expression. ( Boheler, KR; Petrou, M; Wong, K; Yacoub, MH, 1997)
"Iso induced cardiac hypertrophy."	1.30	Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle. ( Kambe, F; Kamiya, K; Nishiyama, A; Seo, H; Toyama, J, 1998)
"We conclude that in this model of cardiac hypertrophy 1) coronary vessel growth parallels the increase in ventricular mass, 2) capillaries grow by proliferation and an increase in diameter, and 3) vascular growth is not notably compromised during senescence."	1.29	Compensated coronary microvascular growth in senescent rats with thyroxine-induced cardiac hypertrophy. ( Butters, CA; Connell, PM; Tomanek, RJ; Torry, RJ, 1995)
"Adaptive cardiac hypertrophy in the rat has been characterized as pathological or physiological reflecting the nature of the inciting stimulus."	1.29	Alterations in gene expression in the rat heart after chronic pathological and physiological loads. ( Buttrick, PM; Kaplan, M; Leinwand, LA; Scheuer, J, 1994)
"Pretreatment with colchicine did not affect the ability of L-thyroxine to induce cardiac hypertrophy but prevented its effects on both beta- and alpha 1-adrenoceptors."	1.28	Disparate effects of colchicine on thyroxine-induced cardiac hypertrophy and adrenoceptor changes. ( Limas, C; Limas, CJ, 1991)
"Pericardial effusion was demonstrated in 15 of the patients, but disappeared during thyroxin therapy."	1.28	[Hypothyroid cardiomyopathy--an underdiagnosed cause of heart failure]. ( Aslaksen, BB; Gallefoss, F; Gundersen, T; Paulsen, AQ, 1990)
"Treatment with propranolol + T4 blunted the coronary blood flow increase, but receptor upregulation occurred to the same extent as with either substance alone."	1.28	Role of beta adrenoceptors in the hypertrophic response to thyroxine. ( Eliades, D; Weiss, HR, 1989)
" The chronic administration of thyroid hormone also results in cardiac hypertrophy and increased numbers of beta-adrenergic receptors in cardiac membranes."	1.27	Regression of thyroid hormone induced cardiac hypertrophy: effect on cardiac beta receptors and adenyl cyclase activity. ( Atkins, FL; Carney, R; Love, S, 1983)
" IPR administered to euthyroid rats in a dosage of 5 mg/kg/day for 4 days induced cardiomegaly."	1.27	Study of the factors influencing cardiac growth. I. Comparison of cardiomegaly induced by isoproterenol in euthyroid and thyroidectomized rats. ( Nosztray, K; Szabó, J; Szegi, J; Takács, IE, 1984)
"Signs of congestive heart failure are absent."	1.27	Cardiac alterations at the myofibrillar level: is a redistribution of the myosin isoenzyme pattern decisive for cardiac failure in haemodynamic overload? ( Ebrecht, G; Jacob, R; Jörg, E; Kissling, G; Rupp, H; Takeda, N, 1984)
"However, cardiac hypertrophy as measured by the increase in cardiac mass was not prevented by such treatment with 1,3-diaminopropanol, showing that the increased content of polyamines was not essential for the hypertrophic response."	1.26	Polyamine metabolism during cardiac hypertrophy. ( Hibasami, H; Pegg, AE, 1980)
"Nineteen patients with untreated hypothyroidism were evaluated by M-mode echocardiography."	1.26	Echocardiographic characterization of the reversible cardiomyopathy of hypothyroidism. ( Cave, WT; Hinojosa, L; Mathew, PK; Miller, RP; Santos, AD; Wallace, WA, 1980)
"Administration of thyroxine daily at a dosage of 6."	1.26	Effects of thyroid hormones on cardiac hypertrophy and beta-adrenergic receptors during aging. ( Roth, GS; Zitnik, G, 1981)

Timeframe	Studies, this research(%)	All Research%
pre-1990	78 (47.27)	18.7374
1990's	32 (19.39)	18.2507
2000's	34 (20.61)	29.6817
2010's	17 (10.30)	24.3611
2020's	4 (2.42)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795]			Phase 4	30 participants (Actual)	Interventional	2017-04-10	Terminated (stopped due to Funding ended)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Hypertension associated with hyperthyroidism and hypothyroidism]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3 Topics: Animals; Atrial Natriuretic Factor; Blood Volume; Cardiomegaly; Catecholamines; Humans; Hypertension	2004
Lysosomes and lysosomal enzymes in the heart. Frontiers of biology, 1975, Volume: 43, Issue:4 Topics: Acid Phosphatase; Adrenal Cortex Hormones; Animals; Cardiomegaly; Cathepsins; Centrifugation, Densit	1975

Article	Year
Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress. European journal of pharmacology, 2022, May-05, Volume: 922 Topics: Angiotensin II; Animals; Antioxidants; Cardiomegaly; Hydrogen; NADPH Oxidase 2; NADPH Oxidases; Oxid	2022
Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways. Scientific reports, 2022, 08-27, Volume: 12, Issue:1 Topics: Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Autophagy; Biphenyl Compounds; Cardiomega	2022
Association between feline hyperthyroidism and thoracic radiographic evaluation of cardiomegaly and pulmonary hyperinflation. Journal of feline medicine and surgery, 2022, Volume: 24, Issue:10 Topics: Animals; Cardiomegaly; Case-Control Studies; Cat Diseases; Cats; Hyperthyroidism; Retrospective Stud	2022
Heart failure in a cat due to hypertrophic cardiomyopathy phenotype caused by chronic uncontrolled hyperthyroidism. Acta veterinaria Hungarica, 2023, 10-17, Volume: 71, Issue:2 Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Cat Diseases; Cats; Furosemide; Heart Failure;	2023
Foetal goitrous hypothyroidism - easy to recognise, difficult to treat. Is combined intra-amniotic and intravenous L-thyroxine therapy an option? Endokrynologia Polska, 2018, Volume: 69, Issue:4 Topics: Cardiomegaly; Congenital Hypothyroidism; Female; Fetal Diseases; Fetus; Humans; Infant, Newborn; Inj	2018
Decreased PGC1- α levels and increased apoptotic protein signaling are associated with the maladaptive cardiac hypertrophy in hyperthyroidism. Journal of biosciences, 2018, Volume: 43, Issue:5 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Cardiomegaly; Gene Expression Regulatio	2018
AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway. Acta biochimica et biophysica Sinica, 2019, Jan-01, Volume: 51, Issue:1 Topics: AMP-Activated Protein Kinases; Animals; Atrial Natriuretic Factor; Body Weight; Cardiomegaly; Gene E	2019
Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles. Journal of cardiovascular pharmacology, 2013, Volume: 61, Issue:6 Topics: Animals; Cardiomegaly; Echocardiography; Electrocardiography; Heart; Heart Ventricles; Hydroxymethyl	2013
Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion. Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:5 Topics: AMP-Activated Protein Kinases; Angiotensin I; Angiotensin II; Angiotensin II Type 2 Receptor Blocker	2013
Cardioprotective effects of thyroid hormones in a rat model of myocardial infarction are associated with oxidative stress reduction. Molecular and cellular endocrinology, 2014, Jun-25, Volume: 391, Issue:1-2 Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catalase; Disease Models, Animal; Glutathione Disulfide;	2014
Prolonged TSH receptor A subunit immunization of female mice leads to a long-term model of Graves' disease, tachycardia, and cardiac hypertrophy. Endocrinology, 2015, Volume: 156, Issue:4 Topics: Adenoviridae; Animals; Autoantibodies; Cardiomegaly; Disease Models, Animal; Female; Graves Disease;	2015
Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight. Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 149, Issue:2 Topics: Animals; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cardiomegaly; Heart Rate; Indoles; M	2016
Cissampelos pareira Linn. ameliorates thyroxin-induced cardiac hypertrophy in rats. Journal of ethnopharmacology, 2016, Feb-03, Volume: 178 Topics: Animals; Antioxidants; Calcineurin; Cardiomegaly; Cissampelos; Glutathione; Glutathione Peroxidase;	2016
Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent. The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:8 Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Aspartic Acid Endopeptidases; Berberine; Cardiomegaly	2008
The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism. Journal of molecular endocrinology, 2008, Volume: 41, Issue:6 Topics: Animals; Ascorbic Acid; Blotting, Western; Cardiomegaly; Disease Models, Animal; Glutathione; Hydrog	2008
Effect of sodium houttuyfonate on myocardial hypertrophy in mice and rats. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:5 Topics: Alkanes; Angiotensin II; Animals; Captopril; Cardiomegaly; Cyclic AMP; Dose-Response Relationship, D	2009
A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II. Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:9 Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Male; Mice; M	2010
A case of myxedema coma caused by isolated thyrotropin stimulating hormone deficiency and Hashimoto's thyroiditis. Endocrine journal, 2011, Volume: 58, Issue:2 Topics: Autoantibodies; Carcinoembryonic Antigen; Cardiomegaly; Coma; Female; Hashimoto Disease; Human Growt	2011
Impact of L-NAME on the cardiopulmonary reflex in cardiac hypertrophy. American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 301, Issue:5 Topics: Animals; Baroreflex; Blood Pressure; Blood Volume; Caffeine; Cardiomegaly; Disease Models, Animal; D	2011
Redox status and pro-survival/pro-apoptotic protein expression in the early cardiac hypertrophy induced by experimental hyperthyroidism. Cell biochemistry and function, 2011, Volume: 29, Issue:7 Topics: Animals; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blotting, Western; Cardiomegaly;	2011
RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism. Toxicology and industrial health, 2012, Volume: 28, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; bcl-2-Associated X Protein; Cardi	2012
Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis. PloS one, 2012, Volume: 7, Issue:8 Topics: Animals; Apoptosis; Blotting, Western; Carbazoles; Cardiomegaly; Cardiomyopathies; Carvedilol; Echoc	2012
Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. Journal of biochemical and molecular toxicology, 2013, Volume: 27, Issue:2 Topics: Animals; Cardiomegaly; Endocrine System; Female; Flame Retardants; Male; Maternal Exposure; Obesity;	2013
Maternal hyperthyroidism alters the pattern of expression of cardiac renin-angiotensin system components in rat offspring. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2014, Volume: 15, Issue:1 Topics: Animals; Animals, Newborn; Cardiomegaly; Female; Fetal Development; Hyperthyroidism; Mothers; Myocar	2014
Effects of anthopleurin-Q on myocardial hypertrophy in rats and physiologic properties of isolated atria in guinea pigs. Acta pharmacologica Sinica, 2002, Volume: 23, Issue:10 Topics: Animals; Aortic Valve Stenosis; Cardiomegaly; Cardiotonic Agents; Guinea Pigs; Heart Atria; In Vitro	2002
[Effects of amiloride on calcium current in thyroxine-induced hypertrophied rat heart]. Yao xue xue bao = Acta pharmaceutica Sinica, 2000, Volume: 35, Issue:12 Topics: Amiloride; Angiotensin II; Animals; Calcium Channels, L-Type; Cardiomegaly; Cell Separation; Female;	2000
Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling. American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 285, Issue:6 Topics: Animals; Blood Pressure; Cardiomegaly; Connective Tissue; Fibrosis; Heart Rate; Male; Myocytes, Card	2003
EFFECT OF THYROXINE AND THIOURACIL ON THE MG++-ACTIVATED ATPASE ON THE RAT MYOCARDIUM. Life sciences (1962), 1964, Volume: 3 Topics: Adenosine Triphosphatases; Adrenal Glands; Cardiomegaly; Magnesium; Myocardium; Pharmacology; Pyruva	1964
HORMONAL INFLUENCES IN REGULATION OF CARDIAC PERFORMANCE. Circulation research, 1964, Volume: 15 Topics: Adrenal Cortex Hormones; Aortic Valve Stenosis; Blood Pressure; Cardiac Output; Cardiomegaly; Growth	1964
[Action of thyroxin, testosterone and somatotropic hormone on experimental hypertrophy of the rat heart]. Rassegna di neurologia vegetativa, 1959, Apr-30, Volume: 14 Topics: Animals; Cardiomegaly; Growth Hormone; Human Growth Hormone; Hypertrophy; Rats; Testosterone; Thyrox	1959
The production of cardiac hypertrophy by thyroxine in the rat. Quarterly journal of experimental physiology and cognate medical sciences, 1959, Volume: 44 Topics: Animals; Cardiomegaly; Rats; Thyroxine	1959
Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy. Acta pharmacologica Sinica, 2004, Volume: 25, Issue:3 Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium-Tran	2004
[Protective effect of berberine on cardiac hypertrophy induced by L-thyroxine in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2004, Volume: 35, Issue:2 Topics: Animals; Berberine; Calcium-Transporting ATPases; Cardiomegaly; Female; Male; Protein Subunits; Rats	2004
Myocardial ultrastructure in cardiac hypertrophy induced by thyroid hormone--an acute study in rats. Virchows Archiv : an international journal of pathology, 2005, Volume: 446, Issue:3 Topics: Animals; Blood Pressure; Cardiomegaly; Heart; Heart Rate; Hyperthyroidism; Hypothyroidism; Male; Mic	2005
L-Thyroxine activates Akt signaling in the heart. Journal of molecular and cellular cardiology, 2005, Volume: 39, Issue:2 Topics: Animals; Cardiomegaly; Contractile Proteins; Enzyme Activation; Female; Heart; Myocardium; Propylthi	2005
Blockade of angiotensin II type 1 receptor diminishes cardiac hypertrophy, but does not abolish thyroxin-induced preconditioning. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2005, Volume: 37, Issue:8 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Cardiomegaly; Irbesartan; Male	2005
Early cardiac hypertrophy induced by thyroxine is accompanied by an increase in VEGF-A expression but not by an increase in capillary density. Virchows Archiv : an international journal of pathology, 2006, Volume: 448, Issue:4 Topics: Animals; Capillaries; Cardiomegaly; Coronary Vessels; Disease Models, Animal; Dose-Response Relation	2006
Importance of ryanodine receptors in effects of cyclic GMP is reduced in thyroxine-induced cardiac hypertrophy. European journal of pharmacology, 2006, May-10, Volume: 537, Issue:1-3 Topics: Animals; Calcium; Calcium Channel Blockers; Cardiomegaly; Cyclic GMP; Dantrolene; Heart Ventricles;	2006
Hyperthyroid hearts display a phenotype of cardioprotection against ischemic stress: a possible involvement of heat shock protein 70. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2006, Volume: 38, Issue:5 Topics: Animals; Cardiomegaly; Cell Survival; Heart; HSP70 Heat-Shock Proteins; Hyperthyroidism; Male; Malon	2006
T4-induced cardiac hypertrophy disrupts cyclic GMP mediated responses to brain natriuretic peptide in rabbit myocardium. Peptides, 2006, Volume: 27, Issue:9 Topics: Animals; Cardiomegaly; Cyclic GMP; Myocardium; Natriuretic Peptide, Brain; Oxygen Consumption; Rabbi	2006
Angiotensin type 1 (AT1) and type 2 (AT2) receptors mediate the increase in TGF-beta1 in thyroid hormone-induced cardiac hypertrophy. Pflugers Archiv : European journal of physiology, 2007, Volume: 454, Issue:1 Topics: Animals; Blood Pressure; Cardiomegaly; Heart Rate; Hyperthyroidism; Hypothyroidism; Myocardium; Orga	2007
Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. European journal of endocrinology, 2007, Volume: 156, Issue:4 Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cell Shape; Echocardiography; In Vitro Techniques; Isomet	2007
Rapamycin prevents thyroid hormone-induced cardiac hypertrophy. Endocrinology, 2007, Volume: 148, Issue:7 Topics: Animals; Animals, Newborn; Blotting, Western; Body Weight; Cardiomegaly; Cell Shape; Cell Size; Cell	2007
Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine. Molecular and cellular biochemistry, 2007, Volume: 303, Issue:1-2 Topics: Animals; Antioxidants; Body Weight; Cardiomegaly; Glutathione; Glutathione Peroxidase; Glutathione T	2007
Recurrent pericardial effusion with a common clinical disorder. The Netherlands journal of medicine, 2007, Volume: 65, Issue:5 Topics: Adult; Cardiomegaly; Down Syndrome; Electrocardiography; Humans; Hypothyroidism; Male; Pericardial E	2007
Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2007, Volume: 32, Issue:2 Topics: Administration, Oral; Animals; Calcium-Binding Proteins; Cardiomegaly; Disease Models, Animal; Echoc	2007
Protective actions of human tissue kallikrein gene in transgenic rat hearts. International immunopharmacology, 2008, Volume: 8, Issue:2 Topics: Animals; Animals, Genetically Modified; Atrial Natriuretic Factor; Cardiomegaly; Collagen Type III;	2008
Cellular mechanisms of reduced sarcoplasmic reticulum Ca2+ content in L-thyroxin induced rat ventricular hypertrophy. Acta pharmacologica Sinica, 2008, Volume: 29, Issue:4 Topics: Animals; Caffeine; Calcium; Cardiomegaly; Electrocardiography; Heart Ventricles; Hypertrophy, Left V	2008
Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats. Experimental physiology, 2008, Volume: 93, Issue:9 Topics: Animals; Baroreflex; Blood Pressure; Body Weight; Caffeine; Cardiomegaly; Central Nervous System Sti	2008
Early ultrastructural changes in the myocardium following thyroxine-induced hypertrophy. Virchows Archiv. B, Cell pathology including molecular pathology, 1980, Volume: 33, Issue:3 Topics: Animals; Cardiomegaly; Female; Microscopy, Electron; Mitochondria, Heart; Myocardium; Myofibrils; Or	1980
Altered myosin isozyme patterns from pressure-overloaded and thyrotoxic hypertrophied rabbit hearts. Circulation research, 1982, Volume: 50, Issue:6 Topics: Adenosine Triphosphatases; Alkylation; Animals; Body Weight; Cardiomegaly; Electrophoresis, Polyacry	1982
Thyroxine-induced hypertrophy of the rabbit heart. Effect on regional oxygen extraction, flow, and oxygen consumption. Circulation research, 1983, Volume: 52, Issue:3 Topics: Animals; Cardiomegaly; Chromonar; Coronary Circulation; Myocardium; Oxygen; Oxygen Consumption; Rabb	1983
Increased protein synthesis and degradation in the dog heart during thyroxine administration. Journal of molecular and cellular cardiology, 1983, Volume: 15, Issue:4 Topics: Animals; Cardiomegaly; Dogs; Heart; Myocardium; Protein Biosynthesis; Proteins; Thyroxine	1983
Some functional changes in experimentally induced cardiac overload. Acta physiologica et pharmacologica Bulgarica, 1983, Volume: 9, Issue:3 Topics: Aminooxyacetic Acid; Animals; Atropine; Cardiomegaly; Disease Models, Animal; Drug Combinations; Ele	1983
Effect of T4-induced cardiac hypertrophy on O2 supply-consumption balance during normoxia and hypoxia. The American journal of physiology, 1984, Volume: 246, Issue:3 Pt 2 Topics: Animals; Carbon Dioxide; Cardiomegaly; Coronary Circulation; Hemodynamics; Hypoxia; Myocardium; Oxyg	1984
Study of the factors influencing cardiac growth. I. Comparison of cardiomegaly induced by isoproterenol in euthyroid and thyroidectomized rats. Acta biologica Hungarica, 1984, Volume: 35, Issue:1 Topics: Animals; Cardiomegaly; Heart; Hypothyroidism; Isoproterenol; Oxygen Consumption; Rats; Thyroidectomy	1984
Cardiac alterations at the myofibrillar level: is a redistribution of the myosin isoenzyme pattern decisive for cardiac failure in haemodynamic overload? European heart journal, 1984, Volume: 5 Suppl F Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Body Weight; Cardiomegaly; Heart Failure; Hemody	1984
Thyroxine-induced changes in characteristics and activities of beta-adrenergic receptors and adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate systems in the heart may be related to reputed catecholamine supersensitivity in hyperthyroidism. Endocrinology, 1980, Volume: 107, Issue:1 Topics: Adenylyl Cyclases; Animals; Cardiomegaly; Cyclic AMP; Cyclic GMP; Dihydroalprenolol; Fluorides; Hear	1980
Effects of thyroid hormones on cardiac hypertrophy and beta-adrenergic receptors during aging. Mechanisms of ageing and development, 1981, Volume: 15, Issue:1 Topics: Aging; Animals; Cardiomegaly; Cell Membrane; Dihydroalprenolol; Male; Myocardium; Rats; Receptors, A	1981
Regression of thyroid hormone induced cardiac hypertrophy: effect on cardiac beta receptors and adenyl cyclase activity. Life sciences, 1983, Aug-15, Volume: 33, Issue:7 Topics: Adenylyl Cyclases; Animals; Cardiomegaly; Cell Membrane; Dihydroalprenolol; Isoproterenol; Kinetics;	1983
Echocardiographic characterization of the reversible cardiomyopathy of hypothyroidism. The American journal of medicine, 1980, Volume: 68, Issue:5 Topics: Adolescent; Adult; Aged; Cardiac Output; Cardiomegaly; Cardiomyopathy, Hypertrophic; Echocardiograph	1980
Effect of thyrotoxicosis and recovery on myocardial protein balance. Advances in myocardiology, 1980, Volume: 1 Topics: Animals; Cardiomegaly; Hyperthyroidism; Male; Myocardium; Organ Culture Techniques; Protein Biosynth	1980
Increased phospholipid methylation in the myocardium of hyperthyroid rats. Biochimica et biophysica acta, 1980, Oct-01, Volume: 632, Issue:2 Topics: Animals; Cardiomegaly; Disease Models, Animal; Hyperthyroidism; Male; Methylation; Microsomes; Myoca	1980
Polyamine metabolism during cardiac hypertrophy. The American journal of physiology, 1980, Volume: 239, Issue:5 Topics: Adenosylmethionine Decarboxylase; Animals; Cardiomegaly; Male; Myocardium; Ornithine Decarboxylase I	1980
Failure of the aldosterone antagonist spironolactone to inhibit myocardial hypertrophy produced by experimental hyperthyroidism and accompanied by "apparent" digoxin immunoreactivity in the blood. Physiologia Bohemoslovaca, 1980, Volume: 29, Issue:6 Topics: Animals; Antigen-Antibody Reactions; Cardiomegaly; Digoxin; Heart; Hyperthyroidism; Male; Organ Size	1980
Effect of alpha-difluoromethylornithine on cardiac polyamine content and hypertrophy. Journal of molecular and cellular cardiology, 1981, Volume: 13, Issue:10 Topics: Animals; Cardiomegaly; Eflornithine; Heart; Male; Myocardium; Ornithine; Ornithine Decarboxylase Inh	1981
Isolation and characterization of two molecular variants of myosin heavy chain from rabbit ventricle. Change in their content during normal growth and after treatment with thyroid hormone. The Journal of biological chemistry, 1982, Feb-25, Volume: 257, Issue:4 Topics: Aging; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Cardiomegaly; Chymotrypsin; Geneti	1982
Myocardial metabolic and functional responses to acetylcholine are altered in thyroxine-induced cardiac hypertrophy. Canadian journal of physiology and pharmacology, 1995, Volume: 73, Issue:6 Topics: Acetylcholine; Animals; Cardiomegaly; Heart; Hemodynamics; Myocardium; Oxygen Consumption; Rabbits;	1995
Phospholipase signalling pathways in thyroxine-induced cardiac hypertrophy. Annals of the New York Academy of Sciences, 1995, Mar-27, Volume: 752 Topics: Animals; Cardiomegaly; Myocardium; Phosphatidylinositols; Phospholipase D; Rats; Rats, Sprague-Dawle	1995
Compensated coronary microvascular growth in senescent rats with thyroxine-induced cardiac hypertrophy. The American journal of physiology, 1995, Volume: 268, Issue:1 Pt 2 Topics: Aging; Animals; Blood Pressure; Body Weight; Capillaries; Cardiomegaly; Coronary Vessels; Diastole;	1995
A role for thyroid hormones in cold-induced elevation of blood pressure and cardiac hypertrophy. Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:9 Topics: Amitrole; Animals; Blood Pressure; Cardiomegaly; Catecholamines; Cold Temperature; Hypertension; Hyp	1994
Relationship between cGMP and myocardial O2 consumption is altered in T4-induced cardiac hypertrophy. The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2 Topics: Animals; Cardiomegaly; Coronary Circulation; Cyclic GMP; Guanylate Cyclase; Myocardium; Nitroprussid	1995
Alterations in gene expression in the rat heart after chronic pathological and physiological loads. Journal of molecular and cellular cardiology, 1994, Volume: 26, Issue:1 Topics: Animals; Cardiomegaly; Catecholamines; Female; Gene Expression; Hypertension, Renovascular; Physical	1994
Cardiac effects of long term thyrotropin-suppressive therapy with levothyroxine. The Journal of clinical endocrinology and metabolism, 1993, Volume: 77, Issue:2 Topics: Adult; Arrhythmias, Cardiac; Blood Pressure; Cardiomegaly; Echocardiography; Electrocardiography; El	1993
Acetylcholine levels, choline acetyltransferase and acetylcholinesterase molecular forms during thyroxine-induced cardiac hypertrophy. Neurochemistry international, 1993, Volume: 22, Issue:2 Topics: Acetylcholine; Acetylcholinesterase; Animals; Cardiomegaly; Choline O-Acetyltransferase; Hyperthyroi	1993
Cardiac hypertrophy as a result of long-term thyroxine therapy and thyrotoxicosis. Heart (British Cardiac Society), 1996, Volume: 75, Issue:4 Topics: Adult; Aged; Cardiomegaly; Cross-Sectional Studies; Echocardiography; Female; Hemodynamics; Humans;	1996
Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism. The American journal of physiology, 1997, Volume: 273, Issue:2 Pt 2 Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Blood; Cardiomegaly; Hemodynamics; Hyperthyroi	1997
Basal muscarinic activity does not impede beta-adrenergic activation in rabbit hearts in controls or thyroxine-induced cardiac hypertrophy. Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:4 Topics: Adrenergic beta-Agonists; Animals; Atropine; Body Weight; Cardiomegaly; Cyclic AMP; Cyclic GMP; Isop	1997
Pharmacological modulation of pressure-overload cardiac hypertrophy: changes in ventricular function, extracellular matrix, and gene expression. Circulation, 1997, Oct-07, Volume: 96, Issue:7 Topics: Analysis of Variance; Animals; Blood Pressure; Calcium-Transporting ATPases; Cardiomegaly; Clenbuter	1997
Coordinated capillary and myocardial growth in response to thyroxine treatment. The Anatomical record, 1998, Volume: 251, Issue:1 Topics: Animals; Capillaries; Cardiomegaly; Heart; Hemodynamics; Male; Neovascularization, Physiologic; Rats	1998
Myocardial effects of cyclic AMP phosphodiesterase inhibition are dampened in thyroxine-induced cardiac hypertrophy. The Journal of surgical research, 1998, Volume: 76, Issue:1 Topics: Animals; Blood Gas Analysis; Body Weight; Cardiomegaly; Coronary Circulation; Cyclic AMP; Endocardiu	1998
Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy. The Journal of endocrinology, 1999, Volume: 160, Issue:1 Topics: Analysis of Variance; Angiotensin II; Animals; Cardiomegaly; Hyperthyroidism; Male; Myocardium; Rats	1999
Propranolol and bepridil attenuating levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:6 Topics: Adrenergic beta-Antagonists; Animals; Bepridil; Ca(2+) Mg(2+)-ATPase; Calcium Channel Blockers; Card	1996
Autonomic contribution to the blood pressure and heart rate variability changes in early experimental hyperthyroidism. Journal of hypertension, 1998, Volume: 16, Issue:12 Pt 2 Topics: Animals; Atenolol; Atropine; Autonomic Nervous System; Blood Pressure; Cardiomegaly; Disease Models,	1998
Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle. Cardiovascular research, 1998, Volume: 40, Issue:2 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Amino Acid Sequence; Animals; Autoradiography	1998
Heart hypertrophy induced by levothyroxine aggravates ischemic lesions and reperfusion arrhythmias in rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:1 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiomegaly; Disease Models, Animal; Female; Male	1997
Chronic levothyroxin treatment is associated with ion channel abnormalities in cardiac and neuronal cells. Clinical and experimental pharmacology & physiology, 1999, Volume: 26, Issue:10 Topics: Animals; Arrhythmias, Cardiac; Calcium Channels, T-Type; Cardiomegaly; Female; Guinea Pigs; Ion Chan	1999
Thyroid hormone-induced overexpression of functional ryanodine receptors in the rabbit heart. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:5 Topics: Animals; Binding, Competitive; Body Weight; Calcium; Calcium Channel Blockers; Cardiomegaly; Heart;	2000
Contribution of de novo protein synthesis to the hypertrophic effect of IGF-1 but not of thyroid hormones in adult ventricular cardiomyocytes. Molecular and cellular biochemistry, 2000, Volume: 206, Issue:1-2 Topics: Animals; Cardiomegaly; Cells, Cultured; DNA; DNA Replication; Heart Ventricles; Insulin-Like Growth	2000
[Contribution of the renin-angiotensin system to blood pressure variability in hyperthyroid rats]. Archives des maladies du coeur et des vaisseaux, 2000, Volume: 93, Issue:8 Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Cardiomegaly; Chronic Dise	2000
Thyroid hormone regulates slow skeletal troponin I gene inactivation in cardiac troponin I null mouse hearts. Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:12 Topics: Animals; Blotting, Northern; Blotting, Western; Cardiomegaly; Down-Regulation; Gene Expression Regul	2000
Differences between the effects of thyroxine and tetraiodothyroacetic acid on TSH suppression and cardiac hypertrophy. European journal of endocrinology, 2001, Volume: 144, Issue:2 Topics: Animals; Calcium-Transporting ATPases; Cardiomegaly; Iodide Peroxidase; Isoenzymes; Liver; Male; Myo	2001
Negative functional effects of cGMP mediated by cGMP protein kinase are reduced in T4 cardiac myocytes. European journal of pharmacology, 2001, Jun-01, Volume: 421, Issue:1 Topics: Alkaloids; Animals; Carbazoles; Cardiomegaly; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Ki	2001
Long-term thyroxine administration increases heat stress protein-70 mRNA expression and attenuates p38 MAP kinase activity in response to ischaemia. The Journal of endocrinology, 2001, Volume: 170, Issue:1 Topics: Animals; Cardiomegaly; Chronic Disease; Electrophoresis, Polyacrylamide Gel; HSP70 Heat-Shock Protei	2001
[Effects of L-thyroxine suppressive therapy on cardiac mass in patients with differentiated thyroid cancer]. Polskie Archiwum Medycyny Wewnetrznej, 2001, Volume: 105, Issue:2 Topics: Adult; Aged; Carcinoma; Cardiomegaly; Female; Humans; Male; Middle Aged; Thyroid Neoplasms; Thyroxin	2001
Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats. International angiology : a journal of the International Union of Angiology, 2001, Volume: 20, Issue:2 Topics: Acetylcholine; Animals; Aorta, Thoracic; Cardiomegaly; Endothelium, Vascular; Hyperthyroidism; Male;	2001
Thyroxine-induced cardiomegaly: assessment of nucleic acid, protein content and myosin ATPase of rat heart. Acta physiologica Academiae Scientiarum Hungaricae, 1979, Volume: 54, Issue:1 Topics: Adenosine Triphosphatases; Animals; Body Weight; Cardiomegaly; Chloromercuribenzoates; DNA; Male; Mu	1979
Adenine nucleotide metabolism during cardiac hypertrophy and ischemia in rats. Journal of molecular and cellular cardiology, 1975, Volume: 7, Issue:2 Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphospha	1975
Changes in protein synthesis in heart. Advances in experimental medicine and biology, 1975, Volume: 61 Topics: Aging; Amino Acids; Animals; Cardiomegaly; Male; Mice; Myocardium; Protein Biosynthesis; Protein Pre	1975
Growth hormone in cardiac hypertrophy induced by nephrogenous hypertension. Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 8 Topics: Animals; Body Weight; Cardiomegaly; Growth Hormone; Heart Ventricles; Hypertension, Renal; Hypophyse	1975
Heart volume and myocardial connective tissue during development and regression of thyroxine-induced cardiac hypertrophy in rats. Acta physiologica Scandinavica, 1976, Volume: 97, Issue:4 Topics: Animals; Body Weight; Cardiac Volume; Cardiomegaly; Collagen; DNA; Heart; Heart Ventricles; Hydroxyp	1976
The myosin isozyme hypothesis in chronic heart overloading. Journal of molecular and cellular cardiology, 1976, Volume: 8, Issue:12 Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; DNA; Dogs; Humans; Isoenzymes; Muscle, Smooth; Mus	1976
[Thyroxine-induced myocardial hypertrophy in rats]. Acta pharmaceutica Hungarica, 1977, Volume: 47, Issue:4 Topics: Cardiomegaly; Hyperthyroidism; Thyroxine	1977
Myofibrillar alkaline protease activity in rat heart and its responses to some interventions that alter cardiac size. Journal of molecular and cellular cardiology, 1978, Volume: 10, Issue:7 Topics: Animals; Autolysis; Cardiomegaly; Cathepsins; Diabetes Mellitus, Experimental; Growth; Isoproterenol	1978
The relationship between fibrosis and lactate dehydrogenase isoenzymes in the experimental hypertrophic heart of rabbits. Cardiovascular research, 1978, Volume: 12, Issue:6 Topics: Animals; Aortic Coarctation; Cardiomegaly; Collagen; Hydroxyproline; Isoenzymes; Isoproterenol; L-La	1978
Synthesis and degradation of myocardial protein during the development and regression of thyroxine-induced cardiac hypertrophy in rats. Circulation research, 1978, Volume: 43, Issue:5 Topics: Amino Acids; Animals; Body Weight; Cardiomegaly; Cycloheximide; Hyperthyroidism; Male; Muscle Protei	1978
Metabolism of lipids in experimental hypertrophic hearts of rabbits. Metabolism: clinical and experimental, 1979, Volume: 28, Issue:6 Topics: Animals; Cardiomegaly; Carnitine; Cholesterol; Fatty Acids; Fatty Acids, Nonesterified; Isoprotereno	1979
Decreased collagen gene expression and absence of fibrosis in thyroid hormone-induced myocardial hypertrophy. Response of cardiac fibroblasts to thyroid hormone in vitro. Circulation research, 1992, Volume: 71, Issue:4 Topics: Acetyltransferases; Animals; Cardiomegaly; Cells, Cultured; Collagen; DNA; Extracellular Matrix; Fib	1992
Decreased collagen mRNA and regression of cardiac fibrosis in the ventricular myocardium of the tight skin mouse following thyroid hormone treatment. Cardiovascular research, 1992, Volume: 26, Issue:6 Topics: Animals; Cardiomegaly; Collagen; Fibrosis; Heart Ventricles; Homeostasis; Male; Mice; Mice, Mutant S	1992
Functional changes in the right and left ventricle during development of cardiac hypertrophy and after its regression. Cardiovascular research, 1992, Volume: 26, Issue:9 Topics: Animals; Cardiomegaly; Collagen; Disease Models, Animal; Heart Ventricles; Isoproterenol; Male; Rats	1992
The real magic. Postgraduate medicine, 1992, Volume: 91, Issue:8 Topics: Adult; Cardiomegaly; Heart Failure; Humans; Hypothyroidism; Male; Thyroxine	1992
In vivo collagen turnover during development of thyroxine-induced left ventricular hypertrophy. The American journal of physiology, 1991, Volume: 260, Issue:2 Pt 1 Topics: Animals; Body Weight; Cardiomegaly; Collagen; Heart Ventricles; Kinetics; Male; Myocardium; Proline;	1991
Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins. Circulation research, 1991, Volume: 69, Issue:2 Topics: Animals; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calsequestrin; Cardiomegal	1991
Effect of sodium deprivation on cardiac hypertrophy in spontaneously hypertensive rats: influence of aging. Journal of molecular and cellular cardiology, 1991, Volume: 23, Issue:6 Topics: Aging; Animals; Cardiomegaly; Diet, Sodium-Restricted; Heart; Hypertension; Male; Myocardium; Myosin	1991
Disparate effects of colchicine on thyroxine-induced cardiac hypertrophy and adrenoceptor changes. Circulation research, 1991, Volume: 68, Issue:1 Topics: Animals; Cardiomegaly; Colchicine; Hyperthyroidism; Male; Myocardium; Rats; Rats, Inbred Strains; Re	1991
Mitochondrial protein synthesis during thyroxine-induced cardiac hypertrophy. The American journal of physiology, 1990, Volume: 258, Issue:3 Pt 1 Topics: Animals; Body Weight; Cardiomegaly; Female; Heart Ventricles; Kinetics; Mitochondria, Heart; Organ S	1990
[Hypothyroid cardiomyopathy--an underdiagnosed cause of heart failure]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1990, Jun-10, Volume: 110, Issue:15 Topics: Aged; Cardiomegaly; Cardiomyopathy, Hypertrophic; Echocardiography; Female; Heart Failure; Heart Sep	1990
Cardiac ornithine decarboxylase of diabetic spontaneously hypertensive rat: effects of insulin and thyroid hormone treatment. Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:3 Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Diabetes Mellitus, Experimental; Heart Rate; Hyp	1990
Thyroxine-induced left ventricular hypertrophy in the rat. Anatomical and physiological evidence for angiogenesis. Circulation research, 1985, Volume: 57, Issue:4 Topics: Animals; Blood Flow Velocity; Blood Pressure; Body Weight; Capillaries; Cardiomegaly; Coronary Circu	1985
Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat. Acta biologica Hungarica, 1986, Volume: 37, Issue:3-4 Topics: Animals; Body Weight; Cardiomegaly; Digitoxin; DNA; Male; Myocardium; Organ Size; Oxygen Consumption	1986
Role of beta adrenoceptors in the hypertrophic response to thyroxine. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:1 Topics: Animals; Blood Pressure; Cardiomegaly; Coronary Circulation; Heart Rate; Iodine Radioisotopes; Organ	1989
Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:8 Topics: Animals; Blood Pressure; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cardiomegaly; Gene	1989
Regional changes in ornithine decarboxylase activity and polyamine levels during thyroxine-induced cardiac hypertrophy. Cytobios, 1989, Volume: 57, Issue:229 Topics: Animals; Cardiomegaly; Heart Atria; Heart Septum; Heart Ventricles; Male; Myocardium; Organ Size; Or	1989
Protein synthesis and degradation during regression of thyroxine-induced cardiac hypertrophy. Journal of molecular and cellular cardiology, 1989, Volume: 21, Issue:9 Topics: Animals; Body Weight; Cardiomegaly; Convalescence; Hemodynamics; Male; Muscle Proteins; Myocardium;	1989
Influence of thyroid status on intracellular distribution of cardiac adrenoceptors. Circulation research, 1987, Volume: 61, Issue:6 Topics: Animals; Cardiomegaly; Cell Membrane; Dihydroalprenolol; Hyperthyroidism; Hypothyroidism; Kinetics;	1987
Induction of a 70,000 dalton protein in hypertrophic rat heart. Experientia, 1985, Nov-15, Volume: 41, Issue:11 Topics: Animals; Aorta; Cardiomegaly; Constriction; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusin	1985
Thyroxine-induced cardiomegaly in rats of different age. Physiologia Bohemoslovaca, 1985, Volume: 34, Issue:5 Topics: Aging; Animals; Cardiomegaly; Heart; Heart Ventricles; Male; Organ Size; Rats; Rats, Inbred Strains;	1985
Isomyosin transitions in ventricles of aldosterone-salt hypertensive rats. Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:2 Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Cardiomegaly; Electrophoresis, Polyacrylamide Gel	1986
Antihypertensive effect of thyroidectomy in SHR: associated changes in heart performance. The American journal of physiology, 1986, Volume: 250, Issue:4 Pt 2 Topics: Age Factors; Animals; Blood Pressure; Body Weight; Cardiomegaly; Female; Heart; Heart Rate; Hyperten	1986
Effects of thyroid hormone on cardiac size and myosin content of the heterotopically transplanted rat heart. The Journal of clinical investigation, 1986, Volume: 77, Issue:5 Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Heart; Heart Rate; Heart Transplantation; Lysine;	1986
Cardiac protein synthesis and degradation during thyroxine-induced left ventricular hypertrophy. The American journal of physiology, 1986, Volume: 251, Issue:5 Pt 1 Topics: Animals; Cardiomegaly; Kinetics; Leucine; Male; Myocardium; Organ Size; Protein Biosynthesis; Protei	1986
Lysosomal changes during thyroxine-induced left ventricular hypertrophy in rabbits. The American journal of physiology, 1986, Volume: 251, Issue:5 Pt 1 Topics: Animals; Cardiomegaly; Cathepsin D; Golgi Apparatus; Histocytochemistry; Lysosomes; Male; Microscopy	1986
Depressor effect of diabetes in the spontaneously hypertensive rat: associated changes in heart performance. Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:9 Topics: Animals; Cardiomegaly; Coronary Circulation; Diabetes Mellitus, Experimental; Food Deprivation; Hear	1986
Microtubule reorganization is related to rate of heart myocyte hypertrophy in rat. The American journal of physiology, 1986, Volume: 251, Issue:6 Pt 2 Topics: Aging; Animals; Cardiomegaly; Female; Fluorescent Antibody Technique; Heart; Hypothyroidism; In Vitr	1986
Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. The Journal of clinical investigation, 1987, Volume: 79, Issue:3 Topics: Animals; Aortic Coarctation; Cardiomegaly; Gene Expression Regulation; Heart Atria; Heart Ventricles	1987
Thyroxine influences on contractile proteins from atrial and ventricular myocardium. Physiologia Bohemoslovaca, 1986, Volume: 35, Issue:6 Topics: Animals; Calcium-Transporting ATPases; Cardiomegaly; Contractile Proteins; Heart; Heart Atria; Heart	1986
Dynamic stiffness of barium-contractured cardiac muscles with different speeds of contraction. Circulation research, 1987, Volume: 60, Issue:5 Topics: Animals; Animals, Newborn; Atrial Function; Barium; Biomechanical Phenomena; Cardiomegaly; Hyperthyr	1987
T4-induced cardiac hypertrophy and the perfused and total microvasculature of the heart. Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:9 Topics: Animals; Blood Gas Analysis; Blood Pressure; Cardiomegaly; Coronary Circulation; Heart Rate; Microci	1987
[Comparison of findings in hypertrophy of the ventricular myocardium in rats after administration of thyroxine and ligation of the aorta]. Ceskoslovenska patologie, 1988, Volume: 24, Issue:1 Topics: Animals; Aorta, Abdominal; Cardiomegaly; Heart Ventricles; Histocytochemistry; Ligation; Myocardium;	1988
Primary hypothyroidism in severe chronic heart failure. Japanese journal of medicine, 1988, Volume: 27, Issue:1 Topics: Adult; Aged; Cardiomegaly; Euthyroid Sick Syndromes; Female; Heart Failure; Heart Function Tests; Hu	1988
Thyroxine-induced cardiac hypertrophy: time course of development and inhibition by propranolol. Endocrinology, 1988, Volume: 123, Issue:1 Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Heart Rate; Kinetics; Male; Myocardium; Propranolo	1988
Sucrose feeding prevents changes in myosin isoenzymes and sarcoplasmic reticulum Ca2+-pump ATPase in pressure-loaded rat heart. Biochemical and biophysical research communications, 1988, Oct-31, Volume: 156, Issue:2 Topics: Animals; Blood Glucose; Calcium-Transporting ATPases; Cardiomegaly; Isoenzymes; Male; Myosins; Organ	1988
Oxygen diffusion distance in thyroxine-induced hypertrophic rabbit myocardium. Journal of molecular and cellular cardiology, 1988, Volume: 20, Issue:10 Topics: Animals; Capillaries; Cardiomegaly; Diffusion; Mitochondria; Myocardium; Oxygen; Rabbits; Thyroxine	1988
The importance of hypophyseal hormones for structural cardiovascular adaptation in hypertension. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1988, Volume: 6, Issue:4 Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Growth Hormone; Heart Rate; Hypertension, Renova	1988
Faster protein and ribosome synthesis in thyroxine-induced hypertrophy of rat heart. The American journal of physiology, 1985, Volume: 248, Issue:3 Pt 1 Topics: Adenine Nucleotides; Amino Acids; Animals; Cardiomegaly; Creatine; Female; Insulin; Perfusion; Phosp	1985
Isomyosin and thyroid hormone levels in pressure-overloaded weanling and adult rat hearts. The American journal of physiology, 1985, Volume: 248, Issue:3 Pt 2 Topics: Animals; Aorta, Abdominal; Blood Pressure; Cardiomegaly; Constriction; Electrophoresis, Polyacrylami	1985
The influence of the plasma inorganic iodine concentration on thyroid function in dehalogenase deficiency. Acta endocrinologica, 1967, Volume: 55, Issue:2 Topics: Adult; Cardiomegaly; Goiter; Humans; Hypothyroidism; Iodine; Iodine Radioisotopes; Male; Metabolism,	1967
Cardiac performance in heart-lung preparations of rats with experimental cardiac hypertrophy. Canadian journal of physiology and pharmacology, 1966, Volume: 44, Issue:1 Topics: Anemia; Animals; Aorta; Cardiac Output; Cardiomegaly; Heart; Hypertrophy; Lung; Rats; Thyroxine	1966
The role of growth hormone and thyroxine in nephrogenic hypertension and cardiac hypertrophy in hypophysectomized rats. Canadian journal of physiology and pharmacology, 1967, Volume: 45, Issue:6 Topics: Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Growth Hormone; Heart Rate; Hypertensio	1967
Coronary-artery enlargement in experimental cardiac hypertrophy. American heart journal, 1968, Volume: 75, Issue:1 Topics: Animals; Arteries; Body Weight; Cardiomegaly; Coronary Vessels; Hypoxia; Male; Organ Size; Rats; Thy	1968
The series elasticity of cardiac muscle in hyperthyroidism, ventricular hypertrophy, and heart failure. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 127, Issue:2 Topics: Animals; Cardiomegaly; Cats; Elasticity; Heart; Heart Failure; Heart Ventricles; Hyperthyroidism; Mu	1968
The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly. The Journal of physiology, 1969, Volume: 200, Issue:2 Topics: Anemia, Hypochromic; Animals; Cardiomegaly; Collagen; Hydroxyproline; Hypertension; Hypertrophy; Hyp	1969
Heart growth in response to aortic constriction in the hypophysectomized rat. The American journal of physiology, 1970, Volume: 218, Issue:3 Topics: Animals; Aorta; Blood Pressure; Body Weight; Cardiomegaly; Constriction; Desoxycorticosterone; Heart	1970
Iodide goiter in the newborn. Pediatrics, 1971, Volume: 47, Issue:3 Topics: Abnormalities, Drug-Induced; Anus, Imperforate; Cardiac Catheterization; Cardiomegaly; Female; Goite	1971
Isolated TSH deficiency presenting as myxedema heart disease. JAMA, 1971, Jul-12, Volume: 217, Issue:2 Topics: Adult; Angiography; Cardiac Catheterization; Cardiac Output; Cardiomegaly; Diagnosis, Differential;	1971
Quantitative electron microscopic description of heart muscle cells. Application to normal, hypertrophied and thyroxin-stimulated hearts. The American journal of cardiology, 1973, Volume: 31, Issue:2 Topics: Animals; Aorta; Cardiomegaly; Cell Membrane; Constriction; Heart; Heart Ventricles; Hypothyroidism;	1973
Effect of age on thyroxine-induced cardiac hypertrophy in mice. Journal of gerontology, 1973, Volume: 28, Issue:3 Topics: Aging; Animals; Body Weight; Cardiomegaly; Dose-Response Relationship, Drug; Injections, Intraperito	1973
Increased myocardial cathepsin D activity during regression of thyrotoxic cardiac hypertrophy. Nature, 1974, May-31, Volume: 249, Issue:456 Topics: Acid Phosphatase; Animals; Body Weight; Cardiomegaly; Cathepsins; Creatine Kinase; Disease Models, A	1974
Role of endocrine factors in the pathogenesis of cardiac hypertrophy. Circulation research, 1974, Volume: 35, Issue:2 Topics: Acromegaly; Animals; Body Weight; Cardiomegaly; Catecholamines; Disease Models, Animal; Growth Hormo	1974
Hemodynamic effects and hypertrophy-inducing potential of D- and L-thyroxine. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:3 Topics: Albumins; Animals; Blood Pressure; Carbon Radioisotopes; Cardiac Output; Cardiomegaly; Heart Atria;	1974
Determinants of thyroxine-induced cardiac hypertrophy in mice. Circulation research, 1966, Volume: 18, Issue:4 Topics: Animals; Blood Circulation; Cardiomegaly; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; My	1966
Copper content and exchange in mammalian hearts. Circulation research, 1974, Volume: 35, Issue:1 Topics: Animals; Cardiomegaly; Cell Membrane; Cell Membrane Permeability; Copper; Electron Transport Complex	1974

thyroxine and Cardiomegaly

Research Excerpts

Research

Studies (165)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Yang, H	1
Bai, J	1
Zhan, C	1
Liu, S	1
Gao, Y	1
Zhong, L	1
Lv, Y	1
Chi, J	1
Liu, J	3
Yang, X	1
Yang, W	1
Khamis, T	1
Alsemeh, AE	1
Abdullah, DM	1
Young, V	1
Rao, S	1
Shropshire, SB	1
Marolf, AJ	1
Lee, H	1
Lee, D	1
Park, J	1
Yun, T	1
Koo, Y	1
Chae, Y	1
Kang, BT	1
Yang, MP	1
Kim, H	1
Dębska, M	1
Gietka-Czernel, M	1
Kretowicz, P	1
Filipecka-Tyczka, D	1
Lewczuk, Ł	1
Dangel, J	1
Dębski, R	1
Teixeira, RB	1
Barboza, TE	1
DE Araujo, CC	1
Siqueira, R	2
DE Castro, AL	2
Bonetto, JHP	1
DE Lima-Seolin, BG	1
Carraro, CC	1
Bello-Klein, A	5
Singal, PK	2
Araujo, ASDR	1
Hu, X	1
Ou-Yang, Q	1
Wang, L	1
Li, T	1
Xie, X	1
Elnakish, MT	2
Moldovan, L	2
Khan, M	2
Hassanain, HH	2
Janssen, PM	2
Tavares, FM	1
da Silva, IB	1
Gomes, DA	1
Barreto-Chaves, ML	6
Tavares, AV	1
Campos, C	1
Fernandes, RO	2
Conzatti, A	1
Bicca, AM	1
Fernandes, TR	4
Sartório, CL	1
Schenkel, PC	2
da Rosa Araujo, AS	1
Holthoff, HP	1
Goebel, S	1
Li, Z	1
Faßbender, J	1
Reimann, A	1
Zeibig, S	1
Lohse, MJ	1
Münch, G	1
Ungerer, M	1
Engle, SK	1
Watson, DE	1
Singh, BK	1
Pillai, KK	1
Kohli, K	1
Haque, SE	1
Du, RH	1
Yi, HW	1
Dai, DZ	5
Tang, WH	1
Dai, Y	1
Araujo, AS	3
Schenkel, P	2
Enzveiler, AT	2
Partata, WA	2
Llesuy, S	2
Ribeiro, MF	3
Khaper, N	1
Gao, JP	1
Chen, CX	1
Wang, Y	1
Lü, J	2
Gu, WL	1
Jiang, SY	1
Xu, M	1
Ma, XW	1
Xiao, H	1
Zhang, YY	1
Iida, K	1
Hino, Y	1
Ohara, T	1
Chihara, K	1
Buckley, MM	2
Johns, EJ	2
Dreher, GJ	1
Na, W	1
Peng, G	1
Jianping, Z	1
Yanzhong, C	1
Shengjiang, G	1
Li, C	1
Hassona, MD	1
Alhaj, MA	1
Patisaul, HB	1
Roberts, SC	1
Mabrey, N	1
McCaffrey, KA	1
Gear, RB	1
Braun, J	1
Belcher, SM	1
Stapleton, HM	1
Lino, CA	1
Shibata, CE	1
Zhou, J	1
Fu, LY	1
Yao, WX	2
Xia, GJ	2
Jiang, MX	2
Wang, JR	1
Wu, ZG	1
Qian, LL	1
Cheng, L	1
Li, XH	1
Hu, LW	2
Benvenuti, LA	1
Liberti, EA	2
Carneiro-Ramos, MS	3
WANG, KM	1
BENMILOUD, M	1
BEZNAK, M	3
POZZI, LL	1
CAGNONI, M	1
FANTINI, F	1
SANDLER, G	1
WILSON, GM	1
Wu, XD	1
Zhang, QP	1
Gao, F	1
Yang, J	1
Zhou, ZY	1
Xu, JG	1
Okada, S	1
Saito, T	1
Yamada, E	1
Mori, M	1
Kuzman, JA	2
Vogelsang, KA	1
Thomas, TA	1
Gerdes, AM	2
Pantos, C	4
Paizis, I	2
Mourouzis, I	5
Moraitis, P	1
Tzeis, S	1
Karamanoli, E	1
Mourouzis, C	1
Karageorgiou, H	1
Cokkinos, DV	6
Anjos-Ramos, L	1
Diniz, GP	2
Martins-Silva, J	1
Zhang, Q	2
Goel, N	1
Rodriguez, R	1
Scholz, PM	4
Weiss, HR	11
Malliopoulou, V	2
Thempeyioti, A	1
Dimopoulos, A	3
Saranteas, T	2
Xinaris, C	3
Katz, E	1
Kokkinos, AD	2
Markakis, K	2
Panagiotou, M	2
Kostopanagiotou, G	1
O'Connell, TD	1
Toorians, AW	1
van Ekelen, WA	1
Silva, JA	1
Silva, MR	1
Nascimento, JW	1
Bader, M	1
Pesquero, JB	1
Song, LJ	1
Wang, GL	1
Qiu, QY	1
Ou, JH	1
Guan, YY	1
Flanagan, ET	1
Aherne, CM	1
Lainis, F	1
Sattar, M	1
Craft-Cormney, C	1
Hansen, JT	1
Litten, RZ	1
Martin, BJ	1
Low, RB	1
Alpert, NR	3
Talafih, K	2
Briden, KL	1
Bonnin, CM	1
Sparrow, MP	1
Taylor, RR	2
Petkov, O	1
Grover, GJ	2
Szabó, J	4
Nosztray, K	4
Takács, IE	2
Szegi, J	4
Jacob, R	1
Kissling, G	1
Ebrecht, G	1
Jörg, E	1
Rupp, H	2
Takeda, N	1
Tse, J	4
Wrenn, RW	1
Kuo, JF	1
Zitnik, G	1
Roth, GS	1
Atkins, FL	1
Carney, R	1
Love, S	1
Santos, AD	1
Miller, RP	1
Mathew, PK	1
Wallace, WA	1
Cave, WT	1
Hinojosa, L	1
Wildenthal, K	5
Sanford, CF	2
Griffin, EE	2
Crie, JS	1
Limas, CJ	3
Pegg, AE	2
Hibasami, H	1
Schreiber, V	1
Stĕpan, J	1
Kölbel, F	1
Pribyl, T	1
Jahodová, J	1
Kubová, V	1
Chizzonite, RA	1
Everett, AW	1
Clark, WA	1
Jakovcic, S	1
Rabinowitz, M	1
Zak, R	1
Fazio, S	2
Biondi, B	2
Carella, C	2
Sabatini, D	1
Cittadini, A	2
Panza, N	1
Lombardi, G	2
Saccà, L	2
Williams, S	1
Mesaeli, N	1
Panagia, V	1
Tomanek, RJ	3
Connell, PM	1
Butters, CA	1
Torry, RJ	1
Fregly, MJ	1
Rossi, F	1
Cade, JR	1
Rodriguez, E	1
Buttrick, PM	1
Kaplan, M	1
Leinwand, LA	1
Scheuer, J	1
Amato, G	1
Lupoli, G	1
Bellastella, A	1
Nyquist-Battie, C	1
Hagler, KE	1
Windberg, L	1
Thottassery, JV	1
Ching, GW	1
Franklyn, JA	1
Stallard, TJ	1
Daykin, J	1
Sheppard, MC	1
Gammage, MD	1
Kobori, H	2
Ichihara, A	2
Suzuki, H	1
Takenaka, T	1
Miyashita, Y	2
Hayashi, M	2
Saruta, T	2
Naim, KL	1
Rabindranauth, P	1
Wong, K	1
Boheler, KR	1
Petrou, M	1
Yacoub, MH	1
Busch, TL	1
Straznicka, M	1
Leone, RJ	1
Chen, DD	1
Zhang, XK	1
Safa-Tisseront, V	1
Ponchon, P	1
Laude, D	1
Elghozi, JL	2
Nishiyama, A	1
Kambe, F	1
Kamiya, K	1
Seo, H	1
Toyama, J	1
Yu, F	1
An, LF	1
Guo, XF	1
Hu, HJ	1
Yang, DM	1
Hao, XM	1
Zhang, GQ	1
Zhou, PA	1
Wu, CH	1
Jiang, M	1
Xu, A	1
Tokmakejian, S	1
Narayanan, N	1
Bell, D	1
McDermott, BJ	1
Basset, A	1
Blanc, J	1
Huang, X	1
Lee, KJ	1
Riedel, B	1
Zhang, C	1
Lemanski, LF	1
Walker, JW	1
Lameloise, N	1
Siegrist-Kaiser, C	1
O'Connell, M	1
Burger, A	1
Engel, S	1
Yan, L	1
Weiss, H	1
Scholz, P	1
Pantos, CI	2
Malliopoulou, VA	1
Mourouzis, IS	1
Karamanoli, EP	1
Tzeis, SM	2
Carageorgiou, HC	1
Varonos, DD	2
Kowalczyk, P	1
Sielańczyk, A	1
Nowak, J	1
Matuszewska, G	1
Roskosz, J	1
Czernik, E	1
Gubała, E	1
Jarzab, B	1
Tzilalis, V	1
Giannakakis, S	1
Cokkinos, DD	1
Asimakopoulos, P	1
Carageorgiou, H	1
Takács, I	1
Degenring, FH	1
Rubio, R	1
Berne, RM	1
Florini, JR	2
Geary, S	1
Saito, Y	2
Manowitz, EJ	2
Sorrentino, RS	1
Powis, RL	1
Edgren, J	1
von Knorring, J	1
Lindy, S	1
Turto, H	1
Takács, E	1
Griffin, WS	1
Revis, NW	2
Cameron, AJ	2
Yao, J	2
Eghbali, M	2
Cihák, R	1
Kolár, F	1
Pelouch, V	1
Procházka, J	1
Ostádal, B	2
Widimský, J	1
Williams, CB	1
Karim, MA	1
Ferguson, AG	1
Wakim, BT	1
Samarel, AM	4
Arai, M	1
Otsu, K	1
MacLennan, DH	2
Periasamy, M	2
Sen, S	1
Young, D	1
Limas, C	2
Leung, AC	1
McKee, EE	1
Gundersen, T	1
Paulsen, AQ	1
Gallefoss, F	1
Aslaksen, BB	1
Christe, ME	1
Rodgers, RL	3
Chilian, WM	1
Wangler, RD	1
Peters, KG	1
Marcus, ML	1
Eliades, D	1
Nagai, R	1
Zarain-Herzberg, A	1
Brandl, CJ	1
Fujii, J	1
Tada, M	1
Tipnis, UR	1
Skiera, C	1
Coleman, PS	1
Parmacek, MS	3
Lesch, M	3
Davalli, P	1
Ferrari, S	1
Corti, A	1
Wachtlová, M	2
Mares, V	1
Martin, AF	2
Paul, RJ	1
McMahon, EG	1
McNeill, JH	1
Klein, I	2
Hong, C	1
Magid, NM	1
Decker, RS	2
Decker, ML	1
Samuel, JL	1
Marotte, F	1
Delcayre, C	1
Rappaport, L	1
Izumo, S	1
Lompré, AM	1
Matsuoka, R	1
Koren, G	1
Schwartz, K	1
Nadal-Ginard, B	1
Mahdavi, V	1
Syrový, I	1
Shibata, T	1
Hunter, WC	1
Sagawa, K	1
Dudorkinová, D	1
Bouska, I	1
Procházka, I	1
Koga, H	1
Kaku, T	1
Hashiba, K	1
Elimban, V	1
Dhalla, NS	1
Seiden, D	1
Navidad, P	1
Folkow, B	1
Isaksson, OP	1
Karlström, G	1
Lever, AF	1
Nordlander, M	1
Siehl, D	1
Chua, BH	1
Lautensack-Belser, N	1
Morgan, HE	1
Robinson, DC	1
Dowell, RT	1
Harden, RM	1
Alexander, WD	1
Papadopoulos, S	1
Harrison, MT	1
Macfarlane, S	1
Korecky, B	2
Korecka, M	1
Kerr, A	1
Bommer, WJ	1
Pilato, S	1
Parmley, WW	1
Spann, JF	1
Sonnenblick, EH	1
Bartosová, D	1
Chvapil, M	1
Poupa, O	1
Rakusan, K	1
Turek, Z	1
Vízek, M	1
Lipana, JG	1
Fanburg, BL	1
Senior, B	1
Chernoff, HL	1
Gupta, MP	1
Kim, S	1
Kang, J	1
Sherman, L	1
Kolodny, HD	1
Hamby, RI	1
Page, E	2
McCallister, LP	2
Mueller, EA	1
Cohen, J	3
Axelrod, GB	1
Whitbeck, AA	1
Aroesty, JM	1
Rosenfeld, MG	1
Earley, J	1
Boyd, C	1