thyroxine has been researched along with Cardiomegaly in 165 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
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" Sacubitril/valsartan (LCZ696) is a new combined drug that has shown promise for the treatment of hyperthyroidism-associated heart failure; however, the underlying molecular mechanisms, including the contributions of epigenetic regulation, remain unclear." | 8.12 | Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways. ( Abdullah, DM; Alsemeh, AE; Khamis, T, 2022) |
" Type 2 Angiotensin II receptors (AT2R) are shown to be upregulated in cardiac hypertrophy observed in hyperthyroidism and this receptor has been reported to mediate cardioprotection against ischemic injury." | 7.79 | Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion. ( Barreto-Chaves, ML; da Silva, IB; Gomes, DA; Tavares, FM, 2013) |
" The purpose of the present study was to evaluate differences in the AMP-activated protein kinase (AMPK) phosphorylation sites in cardiac hypertrophy induced by L-thyroxine and angiotensin (Ang) II." | 7.76 | A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II. ( Jiang, SY; Ma, XW; Xiao, H; Xu, M; Zhang, YY, 2010) |
"Thyroxine can cause cardiac hypertrophy by activating growth factors, such as IGF-I (insulin-like growth factor-I)." | 7.74 | Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine. ( Araujo, AS; Belló-Klein, A; Enzveiler, AT; Fernandes, TR; Llesuy, S; Partata, WA; Ribeiro, MF; Schenkel, P, 2007) |
"The present study assessed the possible involvement of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) in thyroxine (T4)-induced cardiac hypertrophy." | 7.72 | Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling. ( Barreto-Chaves, ML; Benvenuti, LA; Carneiro-Ramos, MS; Hu, LW; Liberti, EA, 2003) |
"To assess the effects of berberine on cardiac hypertrophy induceded by L-thyroxine(L-Thy) in rats." | 7.72 | [Protective effect of berberine on cardiac hypertrophy induced by L-thyroxine in rats]. ( Xu, JG; Yang, J; Zhou, ZY, 2004) |
" The aim of the present study was to evaluate whether the vascular response to potassium chloride and phenylephrine is abnormal in a rat model of thyroxine-induced cardiac hypertrophy." | 7.71 | Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats. ( Asimakopoulos, P; Carageorgiou, H; Cokkinos, DD; Cokkinos, DV; Giannakakis, S; Malliopoulou, V; Mourouzis, I; Pantos, CI; Tzeis, SM; Tzilalis, V; Varonos, DD, 2001) |
"Cross sectional study of patients prescribed thyroxine long term (n = 11), patients with thyrotoxicosis studied at presentation (n = 23), compared with controls (n = 25); longitudinal study of patients with thyrotoxicosis studied at presentation and serially after beginning antithyroid drug treatment (n = 23)." | 7.69 | Cardiac hypertrophy as a result of long-term thyroxine therapy and thyrotoxicosis. ( Ching, GW; Daykin, J; Franklyn, JA; Gammage, MD; Sheppard, MC; Stallard, TJ, 1996) |
"To study the effects of propranolol and bepridil on levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation." | 7.69 | Propranolol and bepridil attenuating levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation. ( Chen, DD; Dai, DZ; Lu, J; Zhang, XK, 1996) |
"Levothyroxine-induced heart hypertrophy is a suitable model for severe ischemia and arrhythmias in rats." | 7.69 | Heart hypertrophy induced by levothyroxine aggravates ischemic lesions and reperfusion arrhythmias in rats. ( An, LF; Dai, DZ; Guo, XF; Yu, F, 1997) |
"The goal of this paper was to determine the effects of 3,5,3'-triiodothyronine (T3)-thyroxine-induced cardiac hypertrophy on the rates of synthesis of mitochondrial proteins by both the cytoplasmic and mitochondrial protein synthesis systems and to compare the results with total protein synthesis and cardiac enlargement." | 7.68 | Mitochondrial protein synthesis during thyroxine-induced cardiac hypertrophy. ( Leung, AC; McKee, EE, 1990) |
"In the present study the effect of thyroxine treatment on the development of cardiomegaly was compared in young (10-day-old) and adult (12-week-old) rats." | 7.67 | Thyroxine-induced cardiomegaly in rats of different age. ( Mares, V; Ostádal, B; Wachtlová, M, 1985) |
"Thyroxine (T4) administered to rats in a dose of 1 mg/kg for 12 days induces cardiac hypertrophy." | 7.67 | Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat. ( Nosztray, K; Szabó, J; Szegi, J; Takács, IE, 1986) |
"Cardiac hypertrophy was induced in rats by daily injections of L-thyroxine (1." | 7.66 | Synthesis and degradation of myocardial protein during the development and regression of thyroxine-induced cardiac hypertrophy in rats. ( Griffin, EE; Sanford, CF; Wildenthal, K, 1978) |
"To determine whether development and regression of cardiac hypertrophy are accompanied by changes in heart volume and to learn whether a change in heart volume is associated with changes in the myocardial connective tissue, cardiac hypertrophy was induced in rats by administration of thyroxine." | 7.65 | Heart volume and myocardial connective tissue during development and regression of thyroxine-induced cardiac hypertrophy in rats. ( Edgren, J; Lindy, S; Turto, H; von Knorring, J, 1976) |
"Hydrogen treatment also reduced the levothyroxine-induced increase in cardiac malondialdehyde, 8-hydroxy-2-deoxyguanosine and serum hydrogen peroxide levels and upregulated superoxide dismutase and glutathione peroxidase activity." | 5.72 | Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress. ( Bai, J; Chi, J; Gao, Y; Liu, J; Liu, S; Lv, Y; Yang, H; Yang, W; Yang, X; Zhan, C; Zhong, L, 2022) |
"Here, cardiac hypertrophy was induced by injection of l-thyroxine or ISO in SD rats." | 5.51 | AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway. ( Hu, X; Li, T; Liu, J; Ou-Yang, Q; Wang, L; Xie, X, 2019) |
"These data indicate that the cardiac hypertrophy induced by acute treatment with thyroid hormone precedes the angiogenic process, which probably occurs later." | 5.33 | Early cardiac hypertrophy induced by thyroxine is accompanied by an increase in VEGF-A expression but not by an increase in capillary density. ( Anjos-Ramos, L; Barreto-Chaves, ML; Carneiro-Ramos, MS; Diniz, GP; Martins-Silva, J, 2006) |
"We conclude that in this model of cardiac hypertrophy 1) coronary vessel growth parallels the increase in ventricular mass, 2) capillaries grow by proliferation and an increase in diameter, and 3) vascular growth is not notably compromised during senescence." | 5.29 | Compensated coronary microvascular growth in senescent rats with thyroxine-induced cardiac hypertrophy. ( Butters, CA; Connell, PM; Tomanek, RJ; Torry, RJ, 1995) |
"Pretreatment with colchicine did not affect the ability of L-thyroxine to induce cardiac hypertrophy but prevented its effects on both beta- and alpha 1-adrenoceptors." | 5.28 | Disparate effects of colchicine on thyroxine-induced cardiac hypertrophy and adrenoceptor changes. ( Limas, C; Limas, CJ, 1991) |
" IPR administered to euthyroid rats in a dosage of 5 mg/kg/day for 4 days induced cardiomegaly." | 5.27 | Study of the factors influencing cardiac growth. I. Comparison of cardiomegaly induced by isoproterenol in euthyroid and thyroidectomized rats. ( Nosztray, K; Szabó, J; Szegi, J; Takács, IE, 1984) |
" Sacubitril/valsartan (LCZ696) is a new combined drug that has shown promise for the treatment of hyperthyroidism-associated heart failure; however, the underlying molecular mechanisms, including the contributions of epigenetic regulation, remain unclear." | 4.12 | Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways. ( Abdullah, DM; Alsemeh, AE; Khamis, T, 2022) |
" Effects included increased serum thyroxine levels and reduced hepatic carboxylesterease activity in dams, and advanced female puberty, weight gain, male cardiac hypertrophy, and altered exploratory behaviors in offspring." | 3.79 | Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. ( Belcher, SM; Braun, J; Gear, RB; Mabrey, N; McCaffrey, KA; Patisaul, HB; Roberts, SC; Stapleton, HM, 2013) |
" Type 2 Angiotensin II receptors (AT2R) are shown to be upregulated in cardiac hypertrophy observed in hyperthyroidism and this receptor has been reported to mediate cardioprotection against ischemic injury." | 3.79 | Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion. ( Barreto-Chaves, ML; da Silva, IB; Gomes, DA; Tavares, FM, 2013) |
"In this study, the role of the RhoA/Rho-kinase (RhoA/ROCK)-signaling pathway in cardiovascular dysfunction associated with hyperthyroidism was examined with the use of fasudil, a Rho-kinase inhibitor." | 3.78 | RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism. ( Jianping, Z; Li, C; Na, W; Peng, G; Shengjiang, G; Yanzhong, C, 2012) |
" The purpose of the present study was to evaluate differences in the AMP-activated protein kinase (AMPK) phosphorylation sites in cardiac hypertrophy induced by L-thyroxine and angiotensin (Ang) II." | 3.76 | A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II. ( Jiang, SY; Ma, XW; Xiao, H; Xu, M; Zhang, YY, 2010) |
" We hypothesized that CPU86017, derived from berberine, which possesses multi-channel blocking activity, could suppress inflammatory factors, resulting in inhibition of over-expression of ether-a-go-go (ERG) and an augmented incidence of ventricular fibrillation (VF) in ischaemia/reperfusion (I/R)." | 3.74 | Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent. ( Dai, DZ; Dai, Y; Du, RH; Tang, WH; Yi, HW, 2008) |
"Thyroxine can cause cardiac hypertrophy by activating growth factors, such as IGF-I (insulin-like growth factor-I)." | 3.74 | Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine. ( Araujo, AS; Belló-Klein, A; Enzveiler, AT; Fernandes, TR; Llesuy, S; Partata, WA; Ribeiro, MF; Schenkel, P, 2007) |
"This study aimed to quantify the effect of cardiac hypertrophy induced with isoprenaline and caffeine on reflex regulation of renal sympathetic nerve activity by the arterial and cardiopulmonary baroreceptors." | 3.74 | Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats. ( Aherne, CM; Buckley, MM; Flanagan, ET; Johns, EJ; Lainis, F; Sattar, M, 2008) |
"The present study assessed the possible involvement of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) in thyroxine (T4)-induced cardiac hypertrophy." | 3.72 | Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling. ( Barreto-Chaves, ML; Benvenuti, LA; Carneiro-Ramos, MS; Hu, LW; Liberti, EA, 2003) |
"Both RyR2 and SERCA mRNA level in L-thyroxin-induced cardiac hypertrophy was over-expressed and propranolol or verapamil inhibited the alteration." | 3.72 | Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy. ( Dai, DZ; Gao, F; Wu, XD; Zhang, QP, 2004) |
"To assess the effects of berberine on cardiac hypertrophy induceded by L-thyroxine(L-Thy) in rats." | 3.72 | [Protective effect of berberine on cardiac hypertrophy induced by L-thyroxine in rats]. ( Xu, JG; Yang, J; Zhou, ZY, 2004) |
" The aim of the present study was to evaluate whether the vascular response to potassium chloride and phenylephrine is abnormal in a rat model of thyroxine-induced cardiac hypertrophy." | 3.71 | Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats. ( Asimakopoulos, P; Carageorgiou, H; Cokkinos, DD; Cokkinos, DV; Giannakakis, S; Malliopoulou, V; Mourouzis, I; Pantos, CI; Tzeis, SM; Tzilalis, V; Varonos, DD, 2001) |
"Patients with differentiated thyroid carcinoma (DTC) receive a life time l-thyroxine therapy in suppressive doses and may exhibit signs of cardiac hypertrophy." | 3.71 | [Effects of L-thyroxine suppressive therapy on cardiac mass in patients with differentiated thyroid cancer]. ( Czernik, E; Gubała, E; Jarzab, B; Kowalczyk, P; Matuszewska, G; Nowak, J; Roskosz, J; Sielańczyk, A, 2001) |
" We investigated the influence of hyperthyroid state on the expression and functional properties of the ryanodine receptor (RyR), a major protein in the junctional SR (JSR), which mediates Ca(2+) release to trigger muscle contraction." | 3.70 | Thyroid hormone-induced overexpression of functional ryanodine receptors in the rabbit heart. ( Jiang, M; Narayanan, N; Tokmakejian, S; Xu, A, 2000) |
"Thyroxine treatment was sufficient to induce a significant degree of tachycardia (423+/-6 vs 353+/-4 bpm, P < 0." | 3.70 | Autonomic contribution to the blood pressure and heart rate variability changes in early experimental hyperthyroidism. ( Elghozi, JL; Laude, D; Ponchon, P; Safa-Tisseront, V, 1998) |
"Cross sectional study of patients prescribed thyroxine long term (n = 11), patients with thyrotoxicosis studied at presentation (n = 23), compared with controls (n = 25); longitudinal study of patients with thyrotoxicosis studied at presentation and serially after beginning antithyroid drug treatment (n = 23)." | 3.69 | Cardiac hypertrophy as a result of long-term thyroxine therapy and thyrotoxicosis. ( Ching, GW; Daykin, J; Franklyn, JA; Gammage, MD; Sheppard, MC; Stallard, TJ, 1996) |
"Levothyroxine-induced heart hypertrophy is a suitable model for severe ischemia and arrhythmias in rats." | 3.69 | Heart hypertrophy induced by levothyroxine aggravates ischemic lesions and reperfusion arrhythmias in rats. ( An, LF; Dai, DZ; Guo, XF; Yu, F, 1997) |
"To study the effects of propranolol and bepridil on levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation." | 3.69 | Propranolol and bepridil attenuating levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation. ( Chen, DD; Dai, DZ; Lu, J; Zhang, XK, 1996) |
"The goal of this paper was to determine the effects of 3,5,3'-triiodothyronine (T3)-thyroxine-induced cardiac hypertrophy on the rates of synthesis of mitochondrial proteins by both the cytoplasmic and mitochondrial protein synthesis systems and to compare the results with total protein synthesis and cardiac enlargement." | 3.68 | Mitochondrial protein synthesis during thyroxine-induced cardiac hypertrophy. ( Leung, AC; McKee, EE, 1990) |
"Two experimental models of cardiac hypertrophy (chronic thyroxine or isoprenaline treatment of adult rats) were compared 24 h and five weeks after the agent was last given." | 3.68 | Functional changes in the right and left ventricle during development of cardiac hypertrophy and after its regression. ( Cihák, R; Kolár, F; Ostádal, B; Pelouch, V; Procházka, J; Widimský, J, 1992) |
"Thyroxine (T4) administered to rats in a dose of 1 mg/kg for 12 days induces cardiac hypertrophy." | 3.67 | Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat. ( Nosztray, K; Szabó, J; Szegi, J; Takács, IE, 1986) |
" During daily injection of l-thyroxine, cardiac hypertrophy developed within 4 days and remained unchanged thereafter." | 3.67 | Influence of thyroid status on intracellular distribution of cardiac adrenoceptors. ( Limas, C; Limas, CJ, 1987) |
"In the present study the effect of thyroxine treatment on the development of cardiomegaly was compared in young (10-day-old) and adult (12-week-old) rats." | 3.67 | Thyroxine-induced cardiomegaly in rats of different age. ( Mares, V; Ostádal, B; Wachtlová, M, 1985) |
"By use of a combined morphologic, immunocytochemical, and biochemical approach, this study demonstrates the changes in the lysosomal vacuolar apparatus that accompany thyroxine-induced cardiac hypertrophy." | 3.67 | Lysosomal changes during thyroxine-induced left ventricular hypertrophy in rabbits. ( Decker, ML; Decker, RS; Lesch, M; Parmacek, MS; Samarel, AM, 1986) |
"Administration of L-thyroxine (1 mg/kg) to adult rats results in cardiac hypertrophy and enhanced contractility." | 3.66 | Increased phospholipid methylation in the myocardium of hyperthyroid rats. ( Limas, CJ, 1980) |
"Cardiac hypertrophy was induced in rabbits by subcutaneous injection of thyroxine or isoprenaline or by surgically constricting the abdominal aorta." | 3.66 | Metabolism of lipids in experimental hypertrophic hearts of rabbits. ( Cameron, AJ; Revis, NW, 1979) |
"Cardiac hypertrophy was induced in rats by daily injections of L-thyroxine (1." | 3.66 | Synthesis and degradation of myocardial protein during the development and regression of thyroxine-induced cardiac hypertrophy in rats. ( Griffin, EE; Sanford, CF; Wildenthal, K, 1978) |
"Cardiac hypertrophy, induced by pressure overload, leads to a depression in the rate of force development, velocity of shortening, tension-dependent heat generation, and myosin ATPase activity, whereas cardiac hypertrophy, induced by thyroxine administration, leads to an increase in these parameters." | 3.66 | Altered myosin isozyme patterns from pressure-overloaded and thyrotoxic hypertrophied rabbit hearts. ( Alpert, NR; Litten, RZ; Low, RB; Martin, BJ, 1982) |
"Cardiac hypertrophy was induced in rabbits by injecting either thyroxine or isoprenaline or by surgically constricting the abdominal aorta." | 3.66 | The relationship between fibrosis and lactate dehydrogenase isoenzymes in the experimental hypertrophic heart of rabbits. ( Cameron, AJ; Revis, NW, 1978) |
" Cardiomegaly has been produced in rats by sideropenic anaemia, by isoprenaline or thyroxine or by the application of both drugs, by artificial increase in resistance to blood flow and by long-term adaptation to hypoxia and physical stress." | 3.65 | The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly. ( Bartosová, D; Chvapil, M; Korecký, B; Poupa, O; Rakusan, K; Turek, Z; Vízek, M, 1969) |
"To determine whether development and regression of cardiac hypertrophy are accompanied by changes in heart volume and to learn whether a change in heart volume is associated with changes in the myocardial connective tissue, cardiac hypertrophy was induced in rats by administration of thyroxine." | 3.65 | Heart volume and myocardial connective tissue during development and regression of thyroxine-induced cardiac hypertrophy in rats. ( Edgren, J; Lindy, S; Turto, H; von Knorring, J, 1976) |
"Based on these findings, the observed congestive heart failure was considered as a sequel of myocardial injury caused by uncontrolled hyperthyroidism." | 1.91 | Heart failure in a cat due to hypertrophic cardiomyopathy phenotype caused by chronic uncontrolled hyperthyroidism. ( Chae, Y; Kang, BT; Kim, H; Koo, Y; Lee, D; Lee, H; Park, J; Yang, MP; Yun, T, 2023) |
"Hyperthyroidism is not associated with radiographic pulmonary hyperinflation and is an unlikely differential for this radiographic finding." | 1.72 | Association between feline hyperthyroidism and thoracic radiographic evaluation of cardiomegaly and pulmonary hyperinflation. ( Marolf, AJ; Rao, S; Shropshire, SB; Young, V, 2022) |
"Hydrogen treatment also reduced the levothyroxine-induced increase in cardiac malondialdehyde, 8-hydroxy-2-deoxyguanosine and serum hydrogen peroxide levels and upregulated superoxide dismutase and glutathione peroxidase activity." | 1.72 | Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress. ( Bai, J; Chi, J; Gao, Y; Liu, J; Liu, S; Lv, Y; Yang, H; Yang, W; Yang, X; Zhan, C; Zhong, L, 2022) |
"Here, cardiac hypertrophy was induced by injection of l-thyroxine or ISO in SD rats." | 1.51 | AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway. ( Hu, X; Li, T; Liu, J; Ou-Yang, Q; Wang, L; Xie, X, 2019) |
"Hyperthyroidism was confirmed by evaluation of T3 and T4 levels, as well as cardiac hypertrophy development." | 1.48 | Decreased PGC1- α levels and increased apoptotic protein signaling are associated with the maladaptive cardiac hypertrophy in hyperthyroidism. ( Araujo, ASDR; Barboza, TE; Bello-Klein, A; Bonetto, JHP; Carraro, CC; DE Araujo, CC; DE Castro, AL; DE Lima-Seolin, BG; Singal, PK; Siqueira, R; Teixeira, RB, 2018) |
" This is a significant limitation because sustained changes in blood pressure are often accompanied by changes in heart rate and together can lead to cardiac hypertrophy and myocardial degeneration in animals, and major adverse cardiovascular events (MACE) in humans." | 1.43 | Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight. ( Engle, SK; Watson, DE, 2016) |
"A transient model for human Graves' disease was successfully established in mice using up to 3 immunizations with recombinant adenovirus expressing the extracellular A-subunit of the human TSH receptor (TSHR) (Ad-TSHR)." | 1.42 | Prolonged TSH receptor A subunit immunization of female mice leads to a long-term model of Graves' disease, tachycardia, and cardiac hypertrophy. ( Faßbender, J; Goebel, S; Holthoff, HP; Li, Z; Lohse, MJ; Münch, G; Reimann, A; Ungerer, M; Zeibig, S, 2015) |
"Maternal hyperthyroidism is associated with alterations in fetal development and altered pattern of expression in RAS components, which in addition to cardiac hypertrophy observed on GD20 may represent an important predisposing factor to cardiovascular diseases in adult life." | 1.40 | Maternal hyperthyroidism alters the pattern of expression of cardiac renin-angiotensin system components in rat offspring. ( Barreto-Chaves, ML; Lino, CA; Shibata, CE, 2014) |
": Development of cardiac hypertrophy after thyroxin (T4) treatment is well recognized." | 1.39 | Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles. ( Elnakish, MT; Hassanain, HH; Janssen, PM; Khan, M; Moldovan, L, 2013) |
"Myxedema coma (MC) is a rare, but often fatal endocrine emergency." | 1.37 | A case of myxedema coma caused by isolated thyrotropin stimulating hormone deficiency and Hashimoto's thyroiditis. ( Chihara, K; Hino, Y; Iida, K; Ohara, T, 2011) |
"Hyperthyroidism was induced by T(4) administration (12 mg/l in drinking water for 28 days)." | 1.35 | The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism. ( Araujo, AS; Belló-Klein, A; Enzveiler, AT; Fernandes, TR; Khaper, N; Llesuy, S; Partata, WA; Ribeiro, MF; Schenkel, P; Singal, PK, 2008) |
"Sodium houttuyfonate can inhibit myocardial hypertrophy in mouse and rat models by restricting the activity of the sympathetic nervous system and decreasing the levels of angiotensin II and endothelin-1 in ventricular tissue." | 1.35 | Effect of sodium houttuyfonate on myocardial hypertrophy in mice and rats. ( Chen, CX; Gao, JP; Gu, WL; Lü, J; Wang, Y, 2009) |
"Induction of cardiac hypertrophy revealed a marked protective effect caused by the expression of the kallikrein transgene, evidenced by the significantly reduced cardiac weight gain and the lower enhancement in the cardiac expression of atrial natriuretic peptide and collagen III, markers for hypertrophy and fibrosis, respectively." | 1.35 | Protective actions of human tissue kallikrein gene in transgenic rat hearts. ( Bader, M; Nascimento, JW; Pesquero, JB; Silva, JA; Silva, MR, 2008) |
"Although THs induce cardiac hypertrophy, the mechanism through which they exert this effect is unknown." | 1.34 | Rapamycin prevents thyroid hormone-induced cardiac hypertrophy. ( Gerdes, AM; Kuzman, JA; O'Connell, TD, 2007) |
"Cardiac hypertrophy was evident in AMI hearts after 13 weeks but not at 2 weeks." | 1.34 | Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. ( Cokkinos, DV; Dimopoulos, A; Kokkinos, AD; Kostopanagiotou, G; Markakis, K; Mourouzis, I; Panagiotou, M; Pantos, C; Saranteas, T; Xinaris, C, 2007) |
"Despite cardiac hypertrophy development, there is no ultrastructural evidence of myocardial degeneration." | 1.33 | Myocardial ultrastructure in cardiac hypertrophy induced by thyroid hormone--an acute study in rats. ( Barreto-Chaves, ML; Hu, LW; Liberti, EA, 2005) |
"These data indicate that the cardiac hypertrophy induced by acute treatment with thyroid hormone precedes the angiogenic process, which probably occurs later." | 1.33 | Early cardiac hypertrophy induced by thyroxine is accompanied by an increase in VEGF-A expression but not by an increase in capillary density. ( Anjos-Ramos, L; Barreto-Chaves, ML; Carneiro-Ramos, MS; Diniz, GP; Martins-Silva, J, 2006) |
"Thyroid hormone induces cardiac hypertrophy and preconditions the myocardium against ischemia reperfusion injury." | 1.33 | Blockade of angiotensin II type 1 receptor diminishes cardiac hypertrophy, but does not abolish thyroxin-induced preconditioning. ( Cokkinos, DV; Karageorgiou, H; Karamanoli, E; Moraitis, P; Mourouzis, C; Mourouzis, I; Paizis, I; Pantos, C; Tzeis, S, 2005) |
"Hyperthyroidism causes physiological cardiac hypertrophy and enhanced function." | 1.33 | L-Thyroxine activates Akt signaling in the heart. ( Gerdes, AM; Kuzman, JA; Thomas, TA; Vogelsang, KA, 2005) |
"Thyrotoxicosis was produced by a daily intraperitoneal (i." | 1.31 | [Contribution of the renin-angiotensin system to blood pressure variability in hyperthyroid rats]. ( Basset, A; Blanc, J; Elghozi, JL, 2000) |
"Thyroid hormone-induced cardiac hypertrophy is a model of enhanced physiological growth and angiogenesis." | 1.30 | Coordinated capillary and myocardial growth in response to thyroxine treatment. ( Busch, TL; Tomanek, RJ, 1998) |
"Appropriate cardiac hypertrophy (CH) is necessary in several clinical settings, such as pulmonary artery banding in the two-stage arterial switch operation for transposition of the great arteries." | 1.30 | Pharmacological modulation of pressure-overload cardiac hypertrophy: changes in ventricular function, extracellular matrix, and gene expression. ( Boheler, KR; Petrou, M; Wong, K; Yacoub, MH, 1997) |
"Iso induced cardiac hypertrophy." | 1.30 | Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle. ( Kambe, F; Kamiya, K; Nishiyama, A; Seo, H; Toyama, J, 1998) |
"We conclude that in this model of cardiac hypertrophy 1) coronary vessel growth parallels the increase in ventricular mass, 2) capillaries grow by proliferation and an increase in diameter, and 3) vascular growth is not notably compromised during senescence." | 1.29 | Compensated coronary microvascular growth in senescent rats with thyroxine-induced cardiac hypertrophy. ( Butters, CA; Connell, PM; Tomanek, RJ; Torry, RJ, 1995) |
"Adaptive cardiac hypertrophy in the rat has been characterized as pathological or physiological reflecting the nature of the inciting stimulus." | 1.29 | Alterations in gene expression in the rat heart after chronic pathological and physiological loads. ( Buttrick, PM; Kaplan, M; Leinwand, LA; Scheuer, J, 1994) |
"Pretreatment with colchicine did not affect the ability of L-thyroxine to induce cardiac hypertrophy but prevented its effects on both beta- and alpha 1-adrenoceptors." | 1.28 | Disparate effects of colchicine on thyroxine-induced cardiac hypertrophy and adrenoceptor changes. ( Limas, C; Limas, CJ, 1991) |
"Pericardial effusion was demonstrated in 15 of the patients, but disappeared during thyroxin therapy." | 1.28 | [Hypothyroid cardiomyopathy--an underdiagnosed cause of heart failure]. ( Aslaksen, BB; Gallefoss, F; Gundersen, T; Paulsen, AQ, 1990) |
"Treatment with propranolol + T4 blunted the coronary blood flow increase, but receptor upregulation occurred to the same extent as with either substance alone." | 1.28 | Role of beta adrenoceptors in the hypertrophic response to thyroxine. ( Eliades, D; Weiss, HR, 1989) |
" The chronic administration of thyroid hormone also results in cardiac hypertrophy and increased numbers of beta-adrenergic receptors in cardiac membranes." | 1.27 | Regression of thyroid hormone induced cardiac hypertrophy: effect on cardiac beta receptors and adenyl cyclase activity. ( Atkins, FL; Carney, R; Love, S, 1983) |
" IPR administered to euthyroid rats in a dosage of 5 mg/kg/day for 4 days induced cardiomegaly." | 1.27 | Study of the factors influencing cardiac growth. I. Comparison of cardiomegaly induced by isoproterenol in euthyroid and thyroidectomized rats. ( Nosztray, K; Szabó, J; Szegi, J; Takács, IE, 1984) |
"Signs of congestive heart failure are absent." | 1.27 | Cardiac alterations at the myofibrillar level: is a redistribution of the myosin isoenzyme pattern decisive for cardiac failure in haemodynamic overload? ( Ebrecht, G; Jacob, R; Jörg, E; Kissling, G; Rupp, H; Takeda, N, 1984) |
"However, cardiac hypertrophy as measured by the increase in cardiac mass was not prevented by such treatment with 1,3-diaminopropanol, showing that the increased content of polyamines was not essential for the hypertrophic response." | 1.26 | Polyamine metabolism during cardiac hypertrophy. ( Hibasami, H; Pegg, AE, 1980) |
"Nineteen patients with untreated hypothyroidism were evaluated by M-mode echocardiography." | 1.26 | Echocardiographic characterization of the reversible cardiomyopathy of hypothyroidism. ( Cave, WT; Hinojosa, L; Mathew, PK; Miller, RP; Santos, AD; Wallace, WA, 1980) |
"Administration of thyroxine daily at a dosage of 6." | 1.26 | Effects of thyroid hormones on cardiac hypertrophy and beta-adrenergic receptors during aging. ( Roth, GS; Zitnik, G, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 78 (47.27) | 18.7374 |
1990's | 32 (19.39) | 18.2507 |
2000's | 34 (20.61) | 29.6817 |
2010's | 17 (10.30) | 24.3611 |
2020's | 4 (2.42) | 2.80 |
Authors | Studies |
---|---|
Yang, H | 1 |
Bai, J | 1 |
Zhan, C | 1 |
Liu, S | 1 |
Gao, Y | 1 |
Zhong, L | 1 |
Lv, Y | 1 |
Chi, J | 1 |
Liu, J | 3 |
Yang, X | 1 |
Yang, W | 1 |
Khamis, T | 1 |
Alsemeh, AE | 1 |
Abdullah, DM | 1 |
Young, V | 1 |
Rao, S | 1 |
Shropshire, SB | 1 |
Marolf, AJ | 1 |
Lee, H | 1 |
Lee, D | 1 |
Park, J | 1 |
Yun, T | 1 |
Koo, Y | 1 |
Chae, Y | 1 |
Kang, BT | 1 |
Yang, MP | 1 |
Kim, H | 1 |
Dębska, M | 1 |
Gietka-Czernel, M | 1 |
Kretowicz, P | 1 |
Filipecka-Tyczka, D | 1 |
Lewczuk, Ł | 1 |
Dangel, J | 1 |
Dębski, R | 1 |
Teixeira, RB | 1 |
Barboza, TE | 1 |
DE Araujo, CC | 1 |
Siqueira, R | 2 |
DE Castro, AL | 2 |
Bonetto, JHP | 1 |
DE Lima-Seolin, BG | 1 |
Carraro, CC | 1 |
Bello-Klein, A | 5 |
Singal, PK | 2 |
Araujo, ASDR | 1 |
Hu, X | 1 |
Ou-Yang, Q | 1 |
Wang, L | 1 |
Li, T | 1 |
Xie, X | 1 |
Elnakish, MT | 2 |
Moldovan, L | 2 |
Khan, M | 2 |
Hassanain, HH | 2 |
Janssen, PM | 2 |
Tavares, FM | 1 |
da Silva, IB | 1 |
Gomes, DA | 1 |
Barreto-Chaves, ML | 6 |
Tavares, AV | 1 |
Campos, C | 1 |
Fernandes, RO | 2 |
Conzatti, A | 1 |
Bicca, AM | 1 |
Fernandes, TR | 4 |
Sartório, CL | 1 |
Schenkel, PC | 2 |
da Rosa Araujo, AS | 1 |
Holthoff, HP | 1 |
Goebel, S | 1 |
Li, Z | 1 |
Faßbender, J | 1 |
Reimann, A | 1 |
Zeibig, S | 1 |
Lohse, MJ | 1 |
Münch, G | 1 |
Ungerer, M | 1 |
Engle, SK | 1 |
Watson, DE | 1 |
Singh, BK | 1 |
Pillai, KK | 1 |
Kohli, K | 1 |
Haque, SE | 1 |
Du, RH | 1 |
Yi, HW | 1 |
Dai, DZ | 5 |
Tang, WH | 1 |
Dai, Y | 1 |
Araujo, AS | 3 |
Schenkel, P | 2 |
Enzveiler, AT | 2 |
Partata, WA | 2 |
Llesuy, S | 2 |
Ribeiro, MF | 3 |
Khaper, N | 1 |
Gao, JP | 1 |
Chen, CX | 1 |
Wang, Y | 1 |
Lü, J | 2 |
Gu, WL | 1 |
Jiang, SY | 1 |
Xu, M | 1 |
Ma, XW | 1 |
Xiao, H | 1 |
Zhang, YY | 1 |
Iida, K | 1 |
Hino, Y | 1 |
Ohara, T | 1 |
Chihara, K | 1 |
Buckley, MM | 2 |
Johns, EJ | 2 |
Dreher, GJ | 1 |
Na, W | 1 |
Peng, G | 1 |
Jianping, Z | 1 |
Yanzhong, C | 1 |
Shengjiang, G | 1 |
Li, C | 1 |
Hassona, MD | 1 |
Alhaj, MA | 1 |
Patisaul, HB | 1 |
Roberts, SC | 1 |
Mabrey, N | 1 |
McCaffrey, KA | 1 |
Gear, RB | 1 |
Braun, J | 1 |
Belcher, SM | 1 |
Stapleton, HM | 1 |
Lino, CA | 1 |
Shibata, CE | 1 |
Zhou, J | 1 |
Fu, LY | 1 |
Yao, WX | 2 |
Xia, GJ | 2 |
Jiang, MX | 2 |
Wang, JR | 1 |
Wu, ZG | 1 |
Qian, LL | 1 |
Cheng, L | 1 |
Li, XH | 1 |
Hu, LW | 2 |
Benvenuti, LA | 1 |
Liberti, EA | 2 |
Carneiro-Ramos, MS | 3 |
WANG, KM | 1 |
BENMILOUD, M | 1 |
BEZNAK, M | 3 |
POZZI, LL | 1 |
CAGNONI, M | 1 |
FANTINI, F | 1 |
SANDLER, G | 1 |
WILSON, GM | 1 |
Wu, XD | 1 |
Zhang, QP | 1 |
Gao, F | 1 |
Yang, J | 1 |
Zhou, ZY | 1 |
Xu, JG | 1 |
Okada, S | 1 |
Saito, T | 1 |
Yamada, E | 1 |
Mori, M | 1 |
Kuzman, JA | 2 |
Vogelsang, KA | 1 |
Thomas, TA | 1 |
Gerdes, AM | 2 |
Pantos, C | 4 |
Paizis, I | 2 |
Mourouzis, I | 5 |
Moraitis, P | 1 |
Tzeis, S | 1 |
Karamanoli, E | 1 |
Mourouzis, C | 1 |
Karageorgiou, H | 1 |
Cokkinos, DV | 6 |
Anjos-Ramos, L | 1 |
Diniz, GP | 2 |
Martins-Silva, J | 1 |
Zhang, Q | 2 |
Goel, N | 1 |
Rodriguez, R | 1 |
Scholz, PM | 4 |
Weiss, HR | 11 |
Malliopoulou, V | 2 |
Thempeyioti, A | 1 |
Dimopoulos, A | 3 |
Saranteas, T | 2 |
Xinaris, C | 3 |
Katz, E | 1 |
Kokkinos, AD | 2 |
Markakis, K | 2 |
Panagiotou, M | 2 |
Kostopanagiotou, G | 1 |
O'Connell, TD | 1 |
Toorians, AW | 1 |
van Ekelen, WA | 1 |
Silva, JA | 1 |
Silva, MR | 1 |
Nascimento, JW | 1 |
Bader, M | 1 |
Pesquero, JB | 1 |
Song, LJ | 1 |
Wang, GL | 1 |
Qiu, QY | 1 |
Ou, JH | 1 |
Guan, YY | 1 |
Flanagan, ET | 1 |
Aherne, CM | 1 |
Lainis, F | 1 |
Sattar, M | 1 |
Craft-Cormney, C | 1 |
Hansen, JT | 1 |
Litten, RZ | 1 |
Martin, BJ | 1 |
Low, RB | 1 |
Alpert, NR | 3 |
Talafih, K | 2 |
Briden, KL | 1 |
Bonnin, CM | 1 |
Sparrow, MP | 1 |
Taylor, RR | 2 |
Petkov, O | 1 |
Grover, GJ | 2 |
Szabó, J | 4 |
Nosztray, K | 4 |
Takács, IE | 2 |
Szegi, J | 4 |
Jacob, R | 1 |
Kissling, G | 1 |
Ebrecht, G | 1 |
Jörg, E | 1 |
Rupp, H | 2 |
Takeda, N | 1 |
Tse, J | 4 |
Wrenn, RW | 1 |
Kuo, JF | 1 |
Zitnik, G | 1 |
Roth, GS | 1 |
Atkins, FL | 1 |
Carney, R | 1 |
Love, S | 1 |
Santos, AD | 1 |
Miller, RP | 1 |
Mathew, PK | 1 |
Wallace, WA | 1 |
Cave, WT | 1 |
Hinojosa, L | 1 |
Wildenthal, K | 5 |
Sanford, CF | 2 |
Griffin, EE | 2 |
Crie, JS | 1 |
Limas, CJ | 3 |
Pegg, AE | 2 |
Hibasami, H | 1 |
Schreiber, V | 1 |
Stĕpan, J | 1 |
Kölbel, F | 1 |
Pribyl, T | 1 |
Jahodová, J | 1 |
Kubová, V | 1 |
Chizzonite, RA | 1 |
Everett, AW | 1 |
Clark, WA | 1 |
Jakovcic, S | 1 |
Rabinowitz, M | 1 |
Zak, R | 1 |
Fazio, S | 2 |
Biondi, B | 2 |
Carella, C | 2 |
Sabatini, D | 1 |
Cittadini, A | 2 |
Panza, N | 1 |
Lombardi, G | 2 |
Saccà, L | 2 |
Williams, S | 1 |
Mesaeli, N | 1 |
Panagia, V | 1 |
Tomanek, RJ | 3 |
Connell, PM | 1 |
Butters, CA | 1 |
Torry, RJ | 1 |
Fregly, MJ | 1 |
Rossi, F | 1 |
Cade, JR | 1 |
Rodriguez, E | 1 |
Buttrick, PM | 1 |
Kaplan, M | 1 |
Leinwand, LA | 1 |
Scheuer, J | 1 |
Amato, G | 1 |
Lupoli, G | 1 |
Bellastella, A | 1 |
Nyquist-Battie, C | 1 |
Hagler, KE | 1 |
Windberg, L | 1 |
Thottassery, JV | 1 |
Ching, GW | 1 |
Franklyn, JA | 1 |
Stallard, TJ | 1 |
Daykin, J | 1 |
Sheppard, MC | 1 |
Gammage, MD | 1 |
Kobori, H | 2 |
Ichihara, A | 2 |
Suzuki, H | 1 |
Takenaka, T | 1 |
Miyashita, Y | 2 |
Hayashi, M | 2 |
Saruta, T | 2 |
Naim, KL | 1 |
Rabindranauth, P | 1 |
Wong, K | 1 |
Boheler, KR | 1 |
Petrou, M | 1 |
Yacoub, MH | 1 |
Busch, TL | 1 |
Straznicka, M | 1 |
Leone, RJ | 1 |
Chen, DD | 1 |
Zhang, XK | 1 |
Safa-Tisseront, V | 1 |
Ponchon, P | 1 |
Laude, D | 1 |
Elghozi, JL | 2 |
Nishiyama, A | 1 |
Kambe, F | 1 |
Kamiya, K | 1 |
Seo, H | 1 |
Toyama, J | 1 |
Yu, F | 1 |
An, LF | 1 |
Guo, XF | 1 |
Hu, HJ | 1 |
Yang, DM | 1 |
Hao, XM | 1 |
Zhang, GQ | 1 |
Zhou, PA | 1 |
Wu, CH | 1 |
Jiang, M | 1 |
Xu, A | 1 |
Tokmakejian, S | 1 |
Narayanan, N | 1 |
Bell, D | 1 |
McDermott, BJ | 1 |
Basset, A | 1 |
Blanc, J | 1 |
Huang, X | 1 |
Lee, KJ | 1 |
Riedel, B | 1 |
Zhang, C | 1 |
Lemanski, LF | 1 |
Walker, JW | 1 |
Lameloise, N | 1 |
Siegrist-Kaiser, C | 1 |
O'Connell, M | 1 |
Burger, A | 1 |
Engel, S | 1 |
Yan, L | 1 |
Weiss, H | 1 |
Scholz, P | 1 |
Pantos, CI | 2 |
Malliopoulou, VA | 1 |
Mourouzis, IS | 1 |
Karamanoli, EP | 1 |
Tzeis, SM | 2 |
Carageorgiou, HC | 1 |
Varonos, DD | 2 |
Kowalczyk, P | 1 |
Sielańczyk, A | 1 |
Nowak, J | 1 |
Matuszewska, G | 1 |
Roskosz, J | 1 |
Czernik, E | 1 |
Gubała, E | 1 |
Jarzab, B | 1 |
Tzilalis, V | 1 |
Giannakakis, S | 1 |
Cokkinos, DD | 1 |
Asimakopoulos, P | 1 |
Carageorgiou, H | 1 |
Takács, I | 1 |
Degenring, FH | 1 |
Rubio, R | 1 |
Berne, RM | 1 |
Florini, JR | 2 |
Geary, S | 1 |
Saito, Y | 2 |
Manowitz, EJ | 2 |
Sorrentino, RS | 1 |
Powis, RL | 1 |
Edgren, J | 1 |
von Knorring, J | 1 |
Lindy, S | 1 |
Turto, H | 1 |
Takács, E | 1 |
Griffin, WS | 1 |
Revis, NW | 2 |
Cameron, AJ | 2 |
Yao, J | 2 |
Eghbali, M | 2 |
Cihák, R | 1 |
Kolár, F | 1 |
Pelouch, V | 1 |
Procházka, J | 1 |
Ostádal, B | 2 |
Widimský, J | 1 |
Williams, CB | 1 |
Karim, MA | 1 |
Ferguson, AG | 1 |
Wakim, BT | 1 |
Samarel, AM | 4 |
Arai, M | 1 |
Otsu, K | 1 |
MacLennan, DH | 2 |
Periasamy, M | 2 |
Sen, S | 1 |
Young, D | 1 |
Limas, C | 2 |
Leung, AC | 1 |
McKee, EE | 1 |
Gundersen, T | 1 |
Paulsen, AQ | 1 |
Gallefoss, F | 1 |
Aslaksen, BB | 1 |
Christe, ME | 1 |
Rodgers, RL | 3 |
Chilian, WM | 1 |
Wangler, RD | 1 |
Peters, KG | 1 |
Marcus, ML | 1 |
Eliades, D | 1 |
Nagai, R | 1 |
Zarain-Herzberg, A | 1 |
Brandl, CJ | 1 |
Fujii, J | 1 |
Tada, M | 1 |
Tipnis, UR | 1 |
Skiera, C | 1 |
Coleman, PS | 1 |
Parmacek, MS | 3 |
Lesch, M | 3 |
Davalli, P | 1 |
Ferrari, S | 1 |
Corti, A | 1 |
Wachtlová, M | 2 |
Mares, V | 1 |
Martin, AF | 2 |
Paul, RJ | 1 |
McMahon, EG | 1 |
McNeill, JH | 1 |
Klein, I | 2 |
Hong, C | 1 |
Magid, NM | 1 |
Decker, RS | 2 |
Decker, ML | 1 |
Samuel, JL | 1 |
Marotte, F | 1 |
Delcayre, C | 1 |
Rappaport, L | 1 |
Izumo, S | 1 |
Lompré, AM | 1 |
Matsuoka, R | 1 |
Koren, G | 1 |
Schwartz, K | 1 |
Nadal-Ginard, B | 1 |
Mahdavi, V | 1 |
Syrový, I | 1 |
Shibata, T | 1 |
Hunter, WC | 1 |
Sagawa, K | 1 |
Dudorkinová, D | 1 |
Bouska, I | 1 |
Procházka, I | 1 |
Koga, H | 1 |
Kaku, T | 1 |
Hashiba, K | 1 |
Elimban, V | 1 |
Dhalla, NS | 1 |
Seiden, D | 1 |
Navidad, P | 1 |
Folkow, B | 1 |
Isaksson, OP | 1 |
Karlström, G | 1 |
Lever, AF | 1 |
Nordlander, M | 1 |
Siehl, D | 1 |
Chua, BH | 1 |
Lautensack-Belser, N | 1 |
Morgan, HE | 1 |
Robinson, DC | 1 |
Dowell, RT | 1 |
Harden, RM | 1 |
Alexander, WD | 1 |
Papadopoulos, S | 1 |
Harrison, MT | 1 |
Macfarlane, S | 1 |
Korecky, B | 2 |
Korecka, M | 1 |
Kerr, A | 1 |
Bommer, WJ | 1 |
Pilato, S | 1 |
Parmley, WW | 1 |
Spann, JF | 1 |
Sonnenblick, EH | 1 |
Bartosová, D | 1 |
Chvapil, M | 1 |
Poupa, O | 1 |
Rakusan, K | 1 |
Turek, Z | 1 |
Vízek, M | 1 |
Lipana, JG | 1 |
Fanburg, BL | 1 |
Senior, B | 1 |
Chernoff, HL | 1 |
Gupta, MP | 1 |
Kim, S | 1 |
Kang, J | 1 |
Sherman, L | 1 |
Kolodny, HD | 1 |
Hamby, RI | 1 |
Page, E | 2 |
McCallister, LP | 2 |
Mueller, EA | 1 |
Cohen, J | 3 |
Axelrod, GB | 1 |
Whitbeck, AA | 1 |
Aroesty, JM | 1 |
Rosenfeld, MG | 1 |
Earley, J | 1 |
Boyd, C | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 reviews available for thyroxine and Cardiomegaly
Article | Year |
---|---|
[Hypertension associated with hyperthyroidism and hypothyroidism].
Topics: Animals; Atrial Natriuretic Factor; Blood Volume; Cardiomegaly; Catecholamines; Humans; Hypertension | 2004 |
Lysosomes and lysosomal enzymes in the heart.
Topics: Acid Phosphatase; Adrenal Cortex Hormones; Animals; Cardiomegaly; Cathepsins; Centrifugation, Densit | 1975 |
1 trial available for thyroxine and Cardiomegaly
Article | Year |
---|---|
Diastolic dysfunction in patients on thyroid-stimulating hormone suppressive therapy with levothyroxine: beneficial effect of beta-blockade.
Topics: Adult; Bisoprolol; Cardiomegaly; Diastole; Echocardiography, Doppler; Female; Goiter; Heart Rate; He | 1995 |
162 other studies available for thyroxine and Cardiomegaly
Article | Year |
---|---|
Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress.
Topics: Angiotensin II; Animals; Antioxidants; Cardiomegaly; Hydrogen; NADPH Oxidase 2; NADPH Oxidases; Oxid | 2022 |
Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways.
Topics: Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Autophagy; Biphenyl Compounds; Cardiomega | 2022 |
Association between feline hyperthyroidism and thoracic radiographic evaluation of cardiomegaly and pulmonary hyperinflation.
Topics: Animals; Cardiomegaly; Case-Control Studies; Cat Diseases; Cats; Hyperthyroidism; Retrospective Stud | 2022 |
Heart failure in a cat due to hypertrophic cardiomyopathy phenotype caused by chronic uncontrolled hyperthyroidism.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Cat Diseases; Cats; Furosemide; Heart Failure; | 2023 |
Foetal goitrous hypothyroidism - easy to recognise, difficult to treat. Is combined intra-amniotic and intravenous L-thyroxine therapy an option?
Topics: Cardiomegaly; Congenital Hypothyroidism; Female; Fetal Diseases; Fetus; Humans; Infant, Newborn; Inj | 2018 |
Decreased PGC1- α levels and increased apoptotic protein signaling are associated with the maladaptive cardiac hypertrophy in hyperthyroidism.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Cardiomegaly; Gene Expression Regulatio | 2018 |
AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway.
Topics: AMP-Activated Protein Kinases; Animals; Atrial Natriuretic Factor; Body Weight; Cardiomegaly; Gene E | 2019 |
Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles.
Topics: Animals; Cardiomegaly; Echocardiography; Electrocardiography; Heart; Heart Ventricles; Hydroxymethyl | 2013 |
Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion.
Topics: AMP-Activated Protein Kinases; Angiotensin I; Angiotensin II; Angiotensin II Type 2 Receptor Blocker | 2013 |
Cardioprotective effects of thyroid hormones in a rat model of myocardial infarction are associated with oxidative stress reduction.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catalase; Disease Models, Animal; Glutathione Disulfide; | 2014 |
Prolonged TSH receptor A subunit immunization of female mice leads to a long-term model of Graves' disease, tachycardia, and cardiac hypertrophy.
Topics: Adenoviridae; Animals; Autoantibodies; Cardiomegaly; Disease Models, Animal; Female; Graves Disease; | 2015 |
Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight.
Topics: Animals; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cardiomegaly; Heart Rate; Indoles; M | 2016 |
Cissampelos pareira Linn. ameliorates thyroxin-induced cardiac hypertrophy in rats.
Topics: Animals; Antioxidants; Calcineurin; Cardiomegaly; Cissampelos; Glutathione; Glutathione Peroxidase; | 2016 |
Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Aspartic Acid Endopeptidases; Berberine; Cardiomegaly | 2008 |
The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism.
Topics: Animals; Ascorbic Acid; Blotting, Western; Cardiomegaly; Disease Models, Animal; Glutathione; Hydrog | 2008 |
Effect of sodium houttuyfonate on myocardial hypertrophy in mice and rats.
Topics: Alkanes; Angiotensin II; Animals; Captopril; Cardiomegaly; Cyclic AMP; Dose-Response Relationship, D | 2009 |
A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Male; Mice; M | 2010 |
A case of myxedema coma caused by isolated thyrotropin stimulating hormone deficiency and Hashimoto's thyroiditis.
Topics: Autoantibodies; Carcinoembryonic Antigen; Cardiomegaly; Coma; Female; Hashimoto Disease; Human Growt | 2011 |
Impact of L-NAME on the cardiopulmonary reflex in cardiac hypertrophy.
Topics: Animals; Baroreflex; Blood Pressure; Blood Volume; Caffeine; Cardiomegaly; Disease Models, Animal; D | 2011 |
Redox status and pro-survival/pro-apoptotic protein expression in the early cardiac hypertrophy induced by experimental hyperthyroidism.
Topics: Animals; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blotting, Western; Cardiomegaly; | 2011 |
RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; bcl-2-Associated X Protein; Cardi | 2012 |
Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis.
Topics: Animals; Apoptosis; Blotting, Western; Carbazoles; Cardiomegaly; Cardiomyopathies; Carvedilol; Echoc | 2012 |
Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment.
Topics: Animals; Cardiomegaly; Endocrine System; Female; Flame Retardants; Male; Maternal Exposure; Obesity; | 2013 |
Maternal hyperthyroidism alters the pattern of expression of cardiac renin-angiotensin system components in rat offspring.
Topics: Animals; Animals, Newborn; Cardiomegaly; Female; Fetal Development; Hyperthyroidism; Mothers; Myocar | 2014 |
Effects of anthopleurin-Q on myocardial hypertrophy in rats and physiologic properties of isolated atria in guinea pigs.
Topics: Animals; Aortic Valve Stenosis; Cardiomegaly; Cardiotonic Agents; Guinea Pigs; Heart Atria; In Vitro | 2002 |
[Effects of amiloride on calcium current in thyroxine-induced hypertrophied rat heart].
Topics: Amiloride; Angiotensin II; Animals; Calcium Channels, L-Type; Cardiomegaly; Cell Separation; Female; | 2000 |
Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling.
Topics: Animals; Blood Pressure; Cardiomegaly; Connective Tissue; Fibrosis; Heart Rate; Male; Myocytes, Card | 2003 |
EFFECT OF THYROXINE AND THIOURACIL ON THE MG++-ACTIVATED ATPASE ON THE RAT MYOCARDIUM.
Topics: Adenosine Triphosphatases; Adrenal Glands; Cardiomegaly; Magnesium; Myocardium; Pharmacology; Pyruva | 1964 |
HORMONAL INFLUENCES IN REGULATION OF CARDIAC PERFORMANCE.
Topics: Adrenal Cortex Hormones; Aortic Valve Stenosis; Blood Pressure; Cardiac Output; Cardiomegaly; Growth | 1964 |
[Action of thyroxin, testosterone and somatotropic hormone on experimental hypertrophy of the rat heart].
Topics: Animals; Cardiomegaly; Growth Hormone; Human Growth Hormone; Hypertrophy; Rats; Testosterone; Thyrox | 1959 |
The production of cardiac hypertrophy by thyroxine in the rat.
Topics: Animals; Cardiomegaly; Rats; Thyroxine | 1959 |
Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium-Tran | 2004 |
[Protective effect of berberine on cardiac hypertrophy induced by L-thyroxine in rats].
Topics: Animals; Berberine; Calcium-Transporting ATPases; Cardiomegaly; Female; Male; Protein Subunits; Rats | 2004 |
Myocardial ultrastructure in cardiac hypertrophy induced by thyroid hormone--an acute study in rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Heart; Heart Rate; Hyperthyroidism; Hypothyroidism; Male; Mic | 2005 |
L-Thyroxine activates Akt signaling in the heart.
Topics: Animals; Cardiomegaly; Contractile Proteins; Enzyme Activation; Female; Heart; Myocardium; Propylthi | 2005 |
Blockade of angiotensin II type 1 receptor diminishes cardiac hypertrophy, but does not abolish thyroxin-induced preconditioning.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Cardiomegaly; Irbesartan; Male | 2005 |
Early cardiac hypertrophy induced by thyroxine is accompanied by an increase in VEGF-A expression but not by an increase in capillary density.
Topics: Animals; Capillaries; Cardiomegaly; Coronary Vessels; Disease Models, Animal; Dose-Response Relation | 2006 |
Importance of ryanodine receptors in effects of cyclic GMP is reduced in thyroxine-induced cardiac hypertrophy.
Topics: Animals; Calcium; Calcium Channel Blockers; Cardiomegaly; Cyclic GMP; Dantrolene; Heart Ventricles; | 2006 |
Hyperthyroid hearts display a phenotype of cardioprotection against ischemic stress: a possible involvement of heat shock protein 70.
Topics: Animals; Cardiomegaly; Cell Survival; Heart; HSP70 Heat-Shock Proteins; Hyperthyroidism; Male; Malon | 2006 |
T4-induced cardiac hypertrophy disrupts cyclic GMP mediated responses to brain natriuretic peptide in rabbit myocardium.
Topics: Animals; Cardiomegaly; Cyclic GMP; Myocardium; Natriuretic Peptide, Brain; Oxygen Consumption; Rabbi | 2006 |
Angiotensin type 1 (AT1) and type 2 (AT2) receptors mediate the increase in TGF-beta1 in thyroid hormone-induced cardiac hypertrophy.
Topics: Animals; Blood Pressure; Cardiomegaly; Heart Rate; Hyperthyroidism; Hypothyroidism; Myocardium; Orga | 2007 |
Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cell Shape; Echocardiography; In Vitro Techniques; Isomet | 2007 |
Rapamycin prevents thyroid hormone-induced cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Blotting, Western; Body Weight; Cardiomegaly; Cell Shape; Cell Size; Cell | 2007 |
Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine.
Topics: Animals; Antioxidants; Body Weight; Cardiomegaly; Glutathione; Glutathione Peroxidase; Glutathione T | 2007 |
Recurrent pericardial effusion with a common clinical disorder.
Topics: Adult; Cardiomegaly; Down Syndrome; Electrocardiography; Humans; Hypothyroidism; Male; Pericardial E | 2007 |
Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats.
Topics: Administration, Oral; Animals; Calcium-Binding Proteins; Cardiomegaly; Disease Models, Animal; Echoc | 2007 |
Protective actions of human tissue kallikrein gene in transgenic rat hearts.
Topics: Animals; Animals, Genetically Modified; Atrial Natriuretic Factor; Cardiomegaly; Collagen Type III; | 2008 |
Cellular mechanisms of reduced sarcoplasmic reticulum Ca2+ content in L-thyroxin induced rat ventricular hypertrophy.
Topics: Animals; Caffeine; Calcium; Cardiomegaly; Electrocardiography; Heart Ventricles; Hypertrophy, Left V | 2008 |
Impact of cardiac hypertrophy on arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity in anaesthetized rats.
Topics: Animals; Baroreflex; Blood Pressure; Body Weight; Caffeine; Cardiomegaly; Central Nervous System Sti | 2008 |
Early ultrastructural changes in the myocardium following thyroxine-induced hypertrophy.
Topics: Animals; Cardiomegaly; Female; Microscopy, Electron; Mitochondria, Heart; Myocardium; Myofibrils; Or | 1980 |
Altered myosin isozyme patterns from pressure-overloaded and thyrotoxic hypertrophied rabbit hearts.
Topics: Adenosine Triphosphatases; Alkylation; Animals; Body Weight; Cardiomegaly; Electrophoresis, Polyacry | 1982 |
Thyroxine-induced hypertrophy of the rabbit heart. Effect on regional oxygen extraction, flow, and oxygen consumption.
Topics: Animals; Cardiomegaly; Chromonar; Coronary Circulation; Myocardium; Oxygen; Oxygen Consumption; Rabb | 1983 |
Increased protein synthesis and degradation in the dog heart during thyroxine administration.
Topics: Animals; Cardiomegaly; Dogs; Heart; Myocardium; Protein Biosynthesis; Proteins; Thyroxine | 1983 |
Some functional changes in experimentally induced cardiac overload.
Topics: Aminooxyacetic Acid; Animals; Atropine; Cardiomegaly; Disease Models, Animal; Drug Combinations; Ele | 1983 |
Effect of T4-induced cardiac hypertrophy on O2 supply-consumption balance during normoxia and hypoxia.
Topics: Animals; Carbon Dioxide; Cardiomegaly; Coronary Circulation; Hemodynamics; Hypoxia; Myocardium; Oxyg | 1984 |
Study of the factors influencing cardiac growth. I. Comparison of cardiomegaly induced by isoproterenol in euthyroid and thyroidectomized rats.
Topics: Animals; Cardiomegaly; Heart; Hypothyroidism; Isoproterenol; Oxygen Consumption; Rats; Thyroidectomy | 1984 |
Cardiac alterations at the myofibrillar level: is a redistribution of the myosin isoenzyme pattern decisive for cardiac failure in haemodynamic overload?
Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Body Weight; Cardiomegaly; Heart Failure; Hemody | 1984 |
Thyroxine-induced changes in characteristics and activities of beta-adrenergic receptors and adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate systems in the heart may be related to reputed catecholamine supersensitivity in hyperthyroidism.
Topics: Adenylyl Cyclases; Animals; Cardiomegaly; Cyclic AMP; Cyclic GMP; Dihydroalprenolol; Fluorides; Hear | 1980 |
Effects of thyroid hormones on cardiac hypertrophy and beta-adrenergic receptors during aging.
Topics: Aging; Animals; Cardiomegaly; Cell Membrane; Dihydroalprenolol; Male; Myocardium; Rats; Receptors, A | 1981 |
Regression of thyroid hormone induced cardiac hypertrophy: effect on cardiac beta receptors and adenyl cyclase activity.
Topics: Adenylyl Cyclases; Animals; Cardiomegaly; Cell Membrane; Dihydroalprenolol; Isoproterenol; Kinetics; | 1983 |
Echocardiographic characterization of the reversible cardiomyopathy of hypothyroidism.
Topics: Adolescent; Adult; Aged; Cardiac Output; Cardiomegaly; Cardiomyopathy, Hypertrophic; Echocardiograph | 1980 |
Effect of thyrotoxicosis and recovery on myocardial protein balance.
Topics: Animals; Cardiomegaly; Hyperthyroidism; Male; Myocardium; Organ Culture Techniques; Protein Biosynth | 1980 |
Increased phospholipid methylation in the myocardium of hyperthyroid rats.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Hyperthyroidism; Male; Methylation; Microsomes; Myoca | 1980 |
Polyamine metabolism during cardiac hypertrophy.
Topics: Adenosylmethionine Decarboxylase; Animals; Cardiomegaly; Male; Myocardium; Ornithine Decarboxylase I | 1980 |
Failure of the aldosterone antagonist spironolactone to inhibit myocardial hypertrophy produced by experimental hyperthyroidism and accompanied by "apparent" digoxin immunoreactivity in the blood.
Topics: Animals; Antigen-Antibody Reactions; Cardiomegaly; Digoxin; Heart; Hyperthyroidism; Male; Organ Size | 1980 |
Effect of alpha-difluoromethylornithine on cardiac polyamine content and hypertrophy.
Topics: Animals; Cardiomegaly; Eflornithine; Heart; Male; Myocardium; Ornithine; Ornithine Decarboxylase Inh | 1981 |
Isolation and characterization of two molecular variants of myosin heavy chain from rabbit ventricle. Change in their content during normal growth and after treatment with thyroid hormone.
Topics: Aging; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Cardiomegaly; Chymotrypsin; Geneti | 1982 |
Myocardial metabolic and functional responses to acetylcholine are altered in thyroxine-induced cardiac hypertrophy.
Topics: Acetylcholine; Animals; Cardiomegaly; Heart; Hemodynamics; Myocardium; Oxygen Consumption; Rabbits; | 1995 |
Phospholipase signalling pathways in thyroxine-induced cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Myocardium; Phosphatidylinositols; Phospholipase D; Rats; Rats, Sprague-Dawle | 1995 |
Compensated coronary microvascular growth in senescent rats with thyroxine-induced cardiac hypertrophy.
Topics: Aging; Animals; Blood Pressure; Body Weight; Capillaries; Cardiomegaly; Coronary Vessels; Diastole; | 1995 |
A role for thyroid hormones in cold-induced elevation of blood pressure and cardiac hypertrophy.
Topics: Amitrole; Animals; Blood Pressure; Cardiomegaly; Catecholamines; Cold Temperature; Hypertension; Hyp | 1994 |
Relationship between cGMP and myocardial O2 consumption is altered in T4-induced cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Coronary Circulation; Cyclic GMP; Guanylate Cyclase; Myocardium; Nitroprussid | 1995 |
Alterations in gene expression in the rat heart after chronic pathological and physiological loads.
Topics: Animals; Cardiomegaly; Catecholamines; Female; Gene Expression; Hypertension, Renovascular; Physical | 1994 |
Cardiac effects of long term thyrotropin-suppressive therapy with levothyroxine.
Topics: Adult; Arrhythmias, Cardiac; Blood Pressure; Cardiomegaly; Echocardiography; Electrocardiography; El | 1993 |
Acetylcholine levels, choline acetyltransferase and acetylcholinesterase molecular forms during thyroxine-induced cardiac hypertrophy.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cardiomegaly; Choline O-Acetyltransferase; Hyperthyroi | 1993 |
Cardiac hypertrophy as a result of long-term thyroxine therapy and thyrotoxicosis.
Topics: Adult; Aged; Cardiomegaly; Cross-Sectional Studies; Echocardiography; Female; Hemodynamics; Humans; | 1996 |
Role of the renin-angiotensin system in cardiac hypertrophy induced in rats by hyperthyroidism.
Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Blood; Cardiomegaly; Hemodynamics; Hyperthyroi | 1997 |
Basal muscarinic activity does not impede beta-adrenergic activation in rabbit hearts in controls or thyroxine-induced cardiac hypertrophy.
Topics: Adrenergic beta-Agonists; Animals; Atropine; Body Weight; Cardiomegaly; Cyclic AMP; Cyclic GMP; Isop | 1997 |
Pharmacological modulation of pressure-overload cardiac hypertrophy: changes in ventricular function, extracellular matrix, and gene expression.
Topics: Analysis of Variance; Animals; Blood Pressure; Calcium-Transporting ATPases; Cardiomegaly; Clenbuter | 1997 |
Coordinated capillary and myocardial growth in response to thyroxine treatment.
Topics: Animals; Capillaries; Cardiomegaly; Heart; Hemodynamics; Male; Neovascularization, Physiologic; Rats | 1998 |
Myocardial effects of cyclic AMP phosphodiesterase inhibition are dampened in thyroxine-induced cardiac hypertrophy.
Topics: Animals; Blood Gas Analysis; Body Weight; Cardiomegaly; Coronary Circulation; Cyclic AMP; Endocardiu | 1998 |
Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy.
Topics: Analysis of Variance; Angiotensin II; Animals; Cardiomegaly; Hyperthyroidism; Male; Myocardium; Rats | 1999 |
Propranolol and bepridil attenuating levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation.
Topics: Adrenergic beta-Antagonists; Animals; Bepridil; Ca(2+) Mg(2+)-ATPase; Calcium Channel Blockers; Card | 1996 |
Autonomic contribution to the blood pressure and heart rate variability changes in early experimental hyperthyroidism.
Topics: Animals; Atenolol; Atropine; Autonomic Nervous System; Blood Pressure; Cardiomegaly; Disease Models, | 1998 |
Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Amino Acid Sequence; Animals; Autoradiography | 1998 |
Heart hypertrophy induced by levothyroxine aggravates ischemic lesions and reperfusion arrhythmias in rats.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiomegaly; Disease Models, Animal; Female; Male | 1997 |
Chronic levothyroxin treatment is associated with ion channel abnormalities in cardiac and neuronal cells.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channels, T-Type; Cardiomegaly; Female; Guinea Pigs; Ion Chan | 1999 |
Thyroid hormone-induced overexpression of functional ryanodine receptors in the rabbit heart.
Topics: Animals; Binding, Competitive; Body Weight; Calcium; Calcium Channel Blockers; Cardiomegaly; Heart; | 2000 |
Contribution of de novo protein synthesis to the hypertrophic effect of IGF-1 but not of thyroid hormones in adult ventricular cardiomyocytes.
Topics: Animals; Cardiomegaly; Cells, Cultured; DNA; DNA Replication; Heart Ventricles; Insulin-Like Growth | 2000 |
[Contribution of the renin-angiotensin system to blood pressure variability in hyperthyroid rats].
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Cardiomegaly; Chronic Dise | 2000 |
Thyroid hormone regulates slow skeletal troponin I gene inactivation in cardiac troponin I null mouse hearts.
Topics: Animals; Blotting, Northern; Blotting, Western; Cardiomegaly; Down-Regulation; Gene Expression Regul | 2000 |
Differences between the effects of thyroxine and tetraiodothyroacetic acid on TSH suppression and cardiac hypertrophy.
Topics: Animals; Calcium-Transporting ATPases; Cardiomegaly; Iodide Peroxidase; Isoenzymes; Liver; Male; Myo | 2001 |
Negative functional effects of cGMP mediated by cGMP protein kinase are reduced in T4 cardiac myocytes.
Topics: Alkaloids; Animals; Carbazoles; Cardiomegaly; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Ki | 2001 |
Long-term thyroxine administration increases heat stress protein-70 mRNA expression and attenuates p38 MAP kinase activity in response to ischaemia.
Topics: Animals; Cardiomegaly; Chronic Disease; Electrophoresis, Polyacrylamide Gel; HSP70 Heat-Shock Protei | 2001 |
[Effects of L-thyroxine suppressive therapy on cardiac mass in patients with differentiated thyroid cancer].
Topics: Adult; Aged; Carcinoma; Cardiomegaly; Female; Humans; Male; Middle Aged; Thyroid Neoplasms; Thyroxin | 2001 |
Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cardiomegaly; Endothelium, Vascular; Hyperthyroidism; Male; | 2001 |
Thyroxine-induced cardiomegaly: assessment of nucleic acid, protein content and myosin ATPase of rat heart.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Cardiomegaly; Chloromercuribenzoates; DNA; Male; Mu | 1979 |
Adenine nucleotide metabolism during cardiac hypertrophy and ischemia in rats.
Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphospha | 1975 |
Changes in protein synthesis in heart.
Topics: Aging; Amino Acids; Animals; Cardiomegaly; Male; Mice; Myocardium; Protein Biosynthesis; Protein Pre | 1975 |
Growth hormone in cardiac hypertrophy induced by nephrogenous hypertension.
Topics: Animals; Body Weight; Cardiomegaly; Growth Hormone; Heart Ventricles; Hypertension, Renal; Hypophyse | 1975 |
Heart volume and myocardial connective tissue during development and regression of thyroxine-induced cardiac hypertrophy in rats.
Topics: Animals; Body Weight; Cardiac Volume; Cardiomegaly; Collagen; DNA; Heart; Heart Ventricles; Hydroxyp | 1976 |
The myosin isozyme hypothesis in chronic heart overloading.
Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; DNA; Dogs; Humans; Isoenzymes; Muscle, Smooth; Mus | 1976 |
[Thyroxine-induced myocardial hypertrophy in rats].
Topics: Cardiomegaly; Hyperthyroidism; Thyroxine | 1977 |
Myofibrillar alkaline protease activity in rat heart and its responses to some interventions that alter cardiac size.
Topics: Animals; Autolysis; Cardiomegaly; Cathepsins; Diabetes Mellitus, Experimental; Growth; Isoproterenol | 1978 |
The relationship between fibrosis and lactate dehydrogenase isoenzymes in the experimental hypertrophic heart of rabbits.
Topics: Animals; Aortic Coarctation; Cardiomegaly; Collagen; Hydroxyproline; Isoenzymes; Isoproterenol; L-La | 1978 |
Synthesis and degradation of myocardial protein during the development and regression of thyroxine-induced cardiac hypertrophy in rats.
Topics: Amino Acids; Animals; Body Weight; Cardiomegaly; Cycloheximide; Hyperthyroidism; Male; Muscle Protei | 1978 |
Metabolism of lipids in experimental hypertrophic hearts of rabbits.
Topics: Animals; Cardiomegaly; Carnitine; Cholesterol; Fatty Acids; Fatty Acids, Nonesterified; Isoprotereno | 1979 |
Decreased collagen gene expression and absence of fibrosis in thyroid hormone-induced myocardial hypertrophy. Response of cardiac fibroblasts to thyroid hormone in vitro.
Topics: Acetyltransferases; Animals; Cardiomegaly; Cells, Cultured; Collagen; DNA; Extracellular Matrix; Fib | 1992 |
Decreased collagen mRNA and regression of cardiac fibrosis in the ventricular myocardium of the tight skin mouse following thyroid hormone treatment.
Topics: Animals; Cardiomegaly; Collagen; Fibrosis; Heart Ventricles; Homeostasis; Male; Mice; Mice, Mutant S | 1992 |
Functional changes in the right and left ventricle during development of cardiac hypertrophy and after its regression.
Topics: Animals; Cardiomegaly; Collagen; Disease Models, Animal; Heart Ventricles; Isoproterenol; Male; Rats | 1992 |
The real magic.
Topics: Adult; Cardiomegaly; Heart Failure; Humans; Hypothyroidism; Male; Thyroxine | 1992 |
In vivo collagen turnover during development of thyroxine-induced left ventricular hypertrophy.
Topics: Animals; Body Weight; Cardiomegaly; Collagen; Heart Ventricles; Kinetics; Male; Myocardium; Proline; | 1991 |
Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins.
Topics: Animals; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calsequestrin; Cardiomegal | 1991 |
Effect of sodium deprivation on cardiac hypertrophy in spontaneously hypertensive rats: influence of aging.
Topics: Aging; Animals; Cardiomegaly; Diet, Sodium-Restricted; Heart; Hypertension; Male; Myocardium; Myosin | 1991 |
Disparate effects of colchicine on thyroxine-induced cardiac hypertrophy and adrenoceptor changes.
Topics: Animals; Cardiomegaly; Colchicine; Hyperthyroidism; Male; Myocardium; Rats; Rats, Inbred Strains; Re | 1991 |
Mitochondrial protein synthesis during thyroxine-induced cardiac hypertrophy.
Topics: Animals; Body Weight; Cardiomegaly; Female; Heart Ventricles; Kinetics; Mitochondria, Heart; Organ S | 1990 |
[Hypothyroid cardiomyopathy--an underdiagnosed cause of heart failure].
Topics: Aged; Cardiomegaly; Cardiomyopathy, Hypertrophic; Echocardiography; Female; Heart Failure; Heart Sep | 1990 |
Cardiac ornithine decarboxylase of diabetic spontaneously hypertensive rat: effects of insulin and thyroid hormone treatment.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Diabetes Mellitus, Experimental; Heart Rate; Hyp | 1990 |
Thyroxine-induced left ventricular hypertrophy in the rat. Anatomical and physiological evidence for angiogenesis.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Body Weight; Capillaries; Cardiomegaly; Coronary Circu | 1985 |
Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat.
Topics: Animals; Body Weight; Cardiomegaly; Digitoxin; DNA; Male; Myocardium; Organ Size; Oxygen Consumption | 1986 |
Role of beta adrenoceptors in the hypertrophic response to thyroxine.
Topics: Animals; Blood Pressure; Cardiomegaly; Coronary Circulation; Heart Rate; Iodine Radioisotopes; Organ | 1989 |
Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.
Topics: Animals; Blood Pressure; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cardiomegaly; Gene | 1989 |
Regional changes in ornithine decarboxylase activity and polyamine levels during thyroxine-induced cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Heart Atria; Heart Septum; Heart Ventricles; Male; Myocardium; Organ Size; Or | 1989 |
Protein synthesis and degradation during regression of thyroxine-induced cardiac hypertrophy.
Topics: Animals; Body Weight; Cardiomegaly; Convalescence; Hemodynamics; Male; Muscle Proteins; Myocardium; | 1989 |
Influence of thyroid status on intracellular distribution of cardiac adrenoceptors.
Topics: Animals; Cardiomegaly; Cell Membrane; Dihydroalprenolol; Hyperthyroidism; Hypothyroidism; Kinetics; | 1987 |
Induction of a 70,000 dalton protein in hypertrophic rat heart.
Topics: Animals; Aorta; Cardiomegaly; Constriction; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusin | 1985 |
Thyroxine-induced cardiomegaly in rats of different age.
Topics: Aging; Animals; Cardiomegaly; Heart; Heart Ventricles; Male; Organ Size; Rats; Rats, Inbred Strains; | 1985 |
Isomyosin transitions in ventricles of aldosterone-salt hypertensive rats.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Cardiomegaly; Electrophoresis, Polyacrylamide Gel | 1986 |
Antihypertensive effect of thyroidectomy in SHR: associated changes in heart performance.
Topics: Age Factors; Animals; Blood Pressure; Body Weight; Cardiomegaly; Female; Heart; Heart Rate; Hyperten | 1986 |
Effects of thyroid hormone on cardiac size and myosin content of the heterotopically transplanted rat heart.
Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Heart; Heart Rate; Heart Transplantation; Lysine; | 1986 |
Cardiac protein synthesis and degradation during thyroxine-induced left ventricular hypertrophy.
Topics: Animals; Cardiomegaly; Kinetics; Leucine; Male; Myocardium; Organ Size; Protein Biosynthesis; Protei | 1986 |
Lysosomal changes during thyroxine-induced left ventricular hypertrophy in rabbits.
Topics: Animals; Cardiomegaly; Cathepsin D; Golgi Apparatus; Histocytochemistry; Lysosomes; Male; Microscopy | 1986 |
Depressor effect of diabetes in the spontaneously hypertensive rat: associated changes in heart performance.
Topics: Animals; Cardiomegaly; Coronary Circulation; Diabetes Mellitus, Experimental; Food Deprivation; Hear | 1986 |
Microtubule reorganization is related to rate of heart myocyte hypertrophy in rat.
Topics: Aging; Animals; Cardiomegaly; Female; Fluorescent Antibody Technique; Heart; Hypothyroidism; In Vitr | 1986 |
Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.
Topics: Animals; Aortic Coarctation; Cardiomegaly; Gene Expression Regulation; Heart Atria; Heart Ventricles | 1987 |
Thyroxine influences on contractile proteins from atrial and ventricular myocardium.
Topics: Animals; Calcium-Transporting ATPases; Cardiomegaly; Contractile Proteins; Heart; Heart Atria; Heart | 1986 |
Dynamic stiffness of barium-contractured cardiac muscles with different speeds of contraction.
Topics: Animals; Animals, Newborn; Atrial Function; Barium; Biomechanical Phenomena; Cardiomegaly; Hyperthyr | 1987 |
T4-induced cardiac hypertrophy and the perfused and total microvasculature of the heart.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Cardiomegaly; Coronary Circulation; Heart Rate; Microci | 1987 |
[Comparison of findings in hypertrophy of the ventricular myocardium in rats after administration of thyroxine and ligation of the aorta].
Topics: Animals; Aorta, Abdominal; Cardiomegaly; Heart Ventricles; Histocytochemistry; Ligation; Myocardium; | 1988 |
Primary hypothyroidism in severe chronic heart failure.
Topics: Adult; Aged; Cardiomegaly; Euthyroid Sick Syndromes; Female; Heart Failure; Heart Function Tests; Hu | 1988 |
Thyroxine-induced cardiac hypertrophy: time course of development and inhibition by propranolol.
Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Heart Rate; Kinetics; Male; Myocardium; Propranolo | 1988 |
Sucrose feeding prevents changes in myosin isoenzymes and sarcoplasmic reticulum Ca2+-pump ATPase in pressure-loaded rat heart.
Topics: Animals; Blood Glucose; Calcium-Transporting ATPases; Cardiomegaly; Isoenzymes; Male; Myosins; Organ | 1988 |
Oxygen diffusion distance in thyroxine-induced hypertrophic rabbit myocardium.
Topics: Animals; Capillaries; Cardiomegaly; Diffusion; Mitochondria; Myocardium; Oxygen; Rabbits; Thyroxine | 1988 |
The importance of hypophyseal hormones for structural cardiovascular adaptation in hypertension.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Growth Hormone; Heart Rate; Hypertension, Renova | 1988 |
Faster protein and ribosome synthesis in thyroxine-induced hypertrophy of rat heart.
Topics: Adenine Nucleotides; Amino Acids; Animals; Cardiomegaly; Creatine; Female; Insulin; Perfusion; Phosp | 1985 |
Isomyosin and thyroid hormone levels in pressure-overloaded weanling and adult rat hearts.
Topics: Animals; Aorta, Abdominal; Blood Pressure; Cardiomegaly; Constriction; Electrophoresis, Polyacrylami | 1985 |
The influence of the plasma inorganic iodine concentration on thyroid function in dehalogenase deficiency.
Topics: Adult; Cardiomegaly; Goiter; Humans; Hypothyroidism; Iodine; Iodine Radioisotopes; Male; Metabolism, | 1967 |
Cardiac performance in heart-lung preparations of rats with experimental cardiac hypertrophy.
Topics: Anemia; Animals; Aorta; Cardiac Output; Cardiomegaly; Heart; Hypertrophy; Lung; Rats; Thyroxine | 1966 |
The role of growth hormone and thyroxine in nephrogenic hypertension and cardiac hypertrophy in hypophysectomized rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Growth Hormone; Heart Rate; Hypertensio | 1967 |
Coronary-artery enlargement in experimental cardiac hypertrophy.
Topics: Animals; Arteries; Body Weight; Cardiomegaly; Coronary Vessels; Hypoxia; Male; Organ Size; Rats; Thy | 1968 |
The series elasticity of cardiac muscle in hyperthyroidism, ventricular hypertrophy, and heart failure.
Topics: Animals; Cardiomegaly; Cats; Elasticity; Heart; Heart Failure; Heart Ventricles; Hyperthyroidism; Mu | 1968 |
The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly.
Topics: Anemia, Hypochromic; Animals; Cardiomegaly; Collagen; Hydroxyproline; Hypertension; Hypertrophy; Hyp | 1969 |
Heart growth in response to aortic constriction in the hypophysectomized rat.
Topics: Animals; Aorta; Blood Pressure; Body Weight; Cardiomegaly; Constriction; Desoxycorticosterone; Heart | 1970 |
Iodide goiter in the newborn.
Topics: Abnormalities, Drug-Induced; Anus, Imperforate; Cardiac Catheterization; Cardiomegaly; Female; Goite | 1971 |
Isolated TSH deficiency presenting as myxedema heart disease.
Topics: Adult; Angiography; Cardiac Catheterization; Cardiac Output; Cardiomegaly; Diagnosis, Differential; | 1971 |
Quantitative electron microscopic description of heart muscle cells. Application to normal, hypertrophied and thyroxin-stimulated hearts.
Topics: Animals; Aorta; Cardiomegaly; Cell Membrane; Constriction; Heart; Heart Ventricles; Hypothyroidism; | 1973 |
Effect of age on thyroxine-induced cardiac hypertrophy in mice.
Topics: Aging; Animals; Body Weight; Cardiomegaly; Dose-Response Relationship, Drug; Injections, Intraperito | 1973 |
Increased myocardial cathepsin D activity during regression of thyrotoxic cardiac hypertrophy.
Topics: Acid Phosphatase; Animals; Body Weight; Cardiomegaly; Cathepsins; Creatine Kinase; Disease Models, A | 1974 |
Role of endocrine factors in the pathogenesis of cardiac hypertrophy.
Topics: Acromegaly; Animals; Body Weight; Cardiomegaly; Catecholamines; Disease Models, Animal; Growth Hormo | 1974 |
Hemodynamic effects and hypertrophy-inducing potential of D- and L-thyroxine.
Topics: Albumins; Animals; Blood Pressure; Carbon Radioisotopes; Cardiac Output; Cardiomegaly; Heart Atria; | 1974 |
Determinants of thyroxine-induced cardiac hypertrophy in mice.
Topics: Animals; Blood Circulation; Cardiomegaly; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; My | 1966 |
Copper content and exchange in mammalian hearts.
Topics: Animals; Cardiomegaly; Cell Membrane; Cell Membrane Permeability; Copper; Electron Transport Complex | 1974 |