thyroxine has been researched along with Cardiac Remodeling, Ventricular in 21 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study assessed the possible involvement of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) in thyroxine (T4)-induced cardiac hypertrophy." | 7.72 | Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling. ( Barreto-Chaves, ML; Benvenuti, LA; Carneiro-Ramos, MS; Hu, LW; Liberti, EA, 2003) |
| "We sought to investigate right ventricular (RV) function and deformation assessed by three-dimensional echocardiography (3DE) and speckle tracking in patients with subclinical hypothyroidism (SHT), and to evaluate the influence of levothyroxine (L-T₄) therapy on RV remodeling." | 3.80 | Right ventricular and right atrial function and deformation in patients with subclinical hypothyroidism: a two- and three-dimensional echocardiographic study. ( Celic, V; Ilic, S; Tadic, M, 2014) |
| "We used 37 Wistar rats, male, adults were randomly divided into four groups: control, hormone (TH), exercise (E), thyroid hormone and exercise (H+E); the group received daily hormone levothyroxine sodium by gavage at a dose of 20 μg thyroid hormone/100g body weight, the exercise group took swimming five times a week, with additional weight corresponding to 20% of body weight for six weeks; in group H+E were applied simultaneously TH treatment groups and E." | 3.80 | Hypertrophic response of the association of thyroid hormone and exercise in the heart of rats. ( Chagas, R; Fidale, T; Gonçalves, A; Lopes, L; Resende, ES; Rodrigues, P; Souza, FR, 2014) |
| " A rat model of thyrotoxicosis was established by daily intraperitoneal injections of L-thyroxine (T(4), 100 μg/kg) for 4 weeks." | 3.78 | Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy. ( Cho, KI; Choi, BG; Jeon, YK; Kang, JH; Kim, BH; Kim, IJ; Kim, JY; Kim, SJ; Kim, SM; Kim, SS; Kim, YK, 2012) |
| "3,5,3'-Levo-triiodothyronine (L-T3) is essential for DNA transcription, mitochondrial biogenesis and respiration, but its circulating levels rapidly decrease after myocardial infarction (MI)." | 3.77 | Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats. ( Ardehali, H; Cecchetti, F; Forini, F; Ghanefar, M; Ichikawa, Y; Iervasi, G; Lionetti, V; Nannipieri, M; Nicolini, G; Pucci, A; Recchia, FA, 2011) |
| "The present study assessed the possible involvement of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) in thyroxine (T4)-induced cardiac hypertrophy." | 3.72 | Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling. ( Barreto-Chaves, ML; Benvenuti, LA; Carneiro-Ramos, MS; Hu, LW; Liberti, EA, 2003) |
| "Sub-clinical hypothyroidism is defined by elevated serum thyroid-stimulating hormone level in the face of normal free thyroid hormone values." | 2.43 | [Cardiovascular remodelling in patients with sub-clinical hypothyroidism]. ( Antonelli, A; Franzoni, F; Galetta, F; Rossi, M; Santoro, G, 2006) |
| "Treatment with ivabradine significantly reduced HR and LVESD, improved SRcirc, S long and SRlong in the T4 group, and the average I Ca,L density at 0 mV in T4-Iva groups (9." | 1.39 | Heart rate reduction with ivabradine prevents thyroid hormone-induced cardiac remodeling in rat. ( Cho, KI; Han, J; Kim, BH; Kim, IJ; Kim, JY; Kim, N; Kim, SM, 2013) |
| "Pravastatin treatment led to inhibition of Rac-GTPase activity and integrin signaling." | 1.37 | Cardiac remodeling caused by transgenic overexpression of a corn Rac gene. ( Abouelnaga, ZA; Alhaj, MA; Awad, MM; Citro, LA; El-Sayed, O; Elnakish, MT; Hassanain, HH; Hassona, MD; Khan, M; Kulkarni, A; Kuppusamy, P; Moldovan, L; Sayyid, M, 2011) |
| "The ventricular remodeling of mice were induced by subcutaneous injection of ISO with the dosage of 2 mg/kg daily for 7 d and the rats with L-Thy intraperitoneally with the dosage of 0." | 1.36 | [Effect of Chrysanthemum indicum on ventricular remodeling in rats]. ( Chen, CX; Gao, JP; Gu, WL; Lv, J; Wan, Y; Wu, Q, 2010) |
| "Cardiac hypertrophy was evident in AMI hearts after 13 weeks but not at 2 weeks." | 1.34 | Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. ( Cokkinos, DV; Dimopoulos, A; Kokkinos, AD; Kostopanagiotou, G; Markakis, K; Mourouzis, I; Panagiotou, M; Pantos, C; Saranteas, T; Xinaris, C, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 15 (71.43) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Khaleel, EF | 1 |
| Repas, SJ | 1 |
| Saad, NS | 1 |
| Janssen, PML | 1 |
| Elnakish, MT | 2 |
| Chen, YF | 1 |
| Weltman, NY | 1 |
| Li, X | 1 |
| Youmans, S | 1 |
| Krause, D | 1 |
| Gerdes, AM | 2 |
| Tadic, M | 1 |
| Ilic, S | 1 |
| Celic, V | 1 |
| Souza, FR | 1 |
| Resende, ES | 1 |
| Lopes, L | 1 |
| Gonçalves, A | 1 |
| Chagas, R | 1 |
| Fidale, T | 1 |
| Rodrigues, P | 1 |
| Corssac, GB | 1 |
| de Castro, AL | 1 |
| Tavares, AV | 1 |
| Campos, C | 1 |
| Fernandes, RO | 1 |
| Ortiz, VD | 1 |
| Siqueira, R | 1 |
| Fernandes, TR | 1 |
| Belló-Klein, A | 1 |
| Araujo, AS | 1 |
| Forini, F | 1 |
| Lionetti, V | 1 |
| Ardehali, H | 1 |
| Pucci, A | 1 |
| Cecchetti, F | 1 |
| Ghanefar, M | 1 |
| Nicolini, G | 1 |
| Ichikawa, Y | 1 |
| Nannipieri, M | 1 |
| Recchia, FA | 1 |
| Iervasi, G | 2 |
| Kalofoutis, C | 1 |
| Mourouzis, I | 4 |
| Galanopoulos, G | 2 |
| Dimopoulos, A | 3 |
| Perimenis, P | 1 |
| Spanou, D | 1 |
| Cokkinos, DV | 5 |
| Singh, J | 1 |
| Pantos, C | 5 |
| Wu, Q | 1 |
| Chen, CX | 1 |
| Gu, WL | 1 |
| Gao, JP | 1 |
| Wan, Y | 1 |
| Lv, J | 1 |
| Pingitore, A | 1 |
| Chen, Y | 1 |
| Awad, MM | 1 |
| Hassona, MD | 1 |
| Alhaj, MA | 1 |
| Kulkarni, A | 1 |
| Citro, LA | 1 |
| Sayyid, M | 1 |
| Abouelnaga, ZA | 1 |
| El-Sayed, O | 1 |
| Kuppusamy, P | 1 |
| Moldovan, L | 1 |
| Khan, M | 1 |
| Hassanain, HH | 1 |
| Celikyurt, U | 1 |
| Agacdiken, A | 1 |
| Geyik, B | 1 |
| Kozdag, G | 1 |
| Vural, A | 1 |
| Ural, D | 1 |
| Mantzouratou, P | 1 |
| Kostakou, E | 1 |
| Roukounakis, N | 1 |
| Kokkinos, AD | 3 |
| Kim, BH | 2 |
| Cho, KI | 2 |
| Kim, SM | 2 |
| Kim, JY | 2 |
| Choi, BG | 1 |
| Kang, JH | 1 |
| Jeon, YK | 1 |
| Kim, SS | 1 |
| Kim, SJ | 1 |
| Kim, YK | 1 |
| Kim, IJ | 2 |
| Kim, N | 1 |
| Han, J | 1 |
| Hu, LW | 1 |
| Benvenuti, LA | 1 |
| Liberti, EA | 1 |
| Carneiro-Ramos, MS | 1 |
| Barreto-Chaves, ML | 1 |
| Xinaris, C | 2 |
| Markakis, K | 2 |
| Panagiotou, M | 2 |
| Saranteas, T | 1 |
| Kostopanagiotou, G | 1 |
| Rossi, M | 1 |
| Galetta, F | 1 |
| Franzoni, F | 1 |
| Antonelli, A | 1 |
| Santoro, G | 1 |
| Ciulla, MM | 1 |
| Paliotti, R | 1 |
| Cortelazzi, D | 1 |
| Tortora, G | 1 |
| Barelli, MV | 1 |
| Buonamici, V | 1 |
| Magrini, F | 1 |
| Beck-Peccoz, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction[NCT02512978] | Phase 4 | 160 participants (Anticipated) | Interventional | 2015-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thyroxine and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Acute myocardial infarction and thyroid function: new pathophysiological and therapeutic perspectives.
Topics: Cell Survival; Heart; Humans; Myocardial Infarction; Myocytes, Cardiac; Receptors, Thyroid Hormone; | 2012 |
[Cardiovascular remodelling in patients with sub-clinical hypothyroidism].
Topics: Atherosclerosis; Carotid Arteries; Humans; Hypothyroidism; Risk Factors; Thyroxine; Ultrasonography; | 2006 |
19 other studies available for thyroxine and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
l-Thyroxine induces left ventricular remodeling and fibrosis in rats by upregulating miR-21 in a reactive oxygen-dependent mechanism: a protective role of
Topics: Acetylcysteine; Actins; Animals; Antagomirs; Collagen; Fibrosis; Glutathione; Inflammasomes; Interle | 2022 |
Memantine, an NMDA Receptor Antagonist, Prevents Thyroxin-induced Hypertension, but Not Cardiac Remodeling.
Topics: Animals; Excitatory Amino Acid Antagonists; Hypertension; Male; Memantine; Mice; Receptors, N-Methyl | 2017 |
Improvement of left ventricular remodeling after myocardial infarction with eight weeks L-thyroxine treatment in rats.
Topics: Animals; Arterioles; Body Weight; Collagen; Echocardiography; Female; Myocardial Infarction; Organ S | 2013 |
Right ventricular and right atrial function and deformation in patients with subclinical hypothyroidism: a two- and three-dimensional echocardiographic study.
Topics: Adult; Atrial Function, Right; Atrial Remodeling; Cardiac Volume; Echocardiography, Doppler, Pulsed; | 2014 |
Hypertrophic response of the association of thyroid hormone and exercise in the heart of rats.
Topics: Animals; Body Weight; Cardiomegaly, Exercise-Induced; Heart; Male; Models, Animal; Organ Size; Physi | 2014 |
Thyroid hormones effects on oxidative stress and cardiac remodeling in the right ventricle of infarcted rats.
Topics: Animals; Echocardiography; Hydrogen Peroxide; Hypertrophy, Right Ventricular; Myocardial Infarction; | 2016 |
Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats.
Topics: Animals; Apoptosis; Blotting, Western; Capillaries; Cells, Cultured; Hemodynamics; Hormone Replaceme | 2011 |
Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction.
Topics: Animals; Diabetes Mellitus, Experimental; Down-Regulation; Genes, erbA; Myocardial Infarction; Rats; | 2010 |
[Effect of Chrysanthemum indicum on ventricular remodeling in rats].
Topics: Aldosterone; Angiotensin II; Animals; Chrysanthemum; Disease Models, Animal; Drugs, Chinese Herbal; | 2010 |
Cardiac remodeling caused by transgenic overexpression of a corn Rac gene.
Topics: Aging; Amino Acid Sequence; Analysis of Variance; Animals; Echocardiography; Genotype; Hypertrophy, | 2011 |
Effect of cardiac resynchronization therapy on thyroid function.
Topics: Adult; Aged; Biomarkers; Cardiac Resynchronization Therapy; Female; Heart Failure; Humans; Male; Mid | 2011 |
[Type 1 diabetes impairs compensatory response after myocardial infarction; role of tissue hypothyroidism and effects of thyroid hormone administration].
Topics: Animals; Diabetes Mellitus, Type 1; Hypothyroidism; Male; Myocardial Infarction; Myocardium; Rats; T | 2011 |
Dose-dependent effects of thyroid hormone on post-ischemic cardiac performance: potential involvement of Akt and ERK signalings.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MA | 2012 |
Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Cardiomyopathies; Echocardiogr | 2012 |
Heart rate reduction with ivabradine prevents thyroid hormone-induced cardiac remodeling in rat.
Topics: Animals; Anti-Arrhythmia Agents; Benzazepines; Calcium Signaling; Disease Models, Animal; Fibrosis; | 2013 |
Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling.
Topics: Animals; Blood Pressure; Cardiomegaly; Connective Tissue; Fibrosis; Heart Rate; Male; Myocytes, Card | 2003 |
Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cell Shape; Echocardiography; In Vitro Techniques; Isomet | 2007 |
Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats.
Topics: Administration, Oral; Animals; Calcium-Binding Proteins; Cardiomegaly; Disease Models, Animal; Echoc | 2007 |
Effects of thyroid hormones on cardiac structure: a tissue characterization study in patients with thyroid disorders before and after treatment.
Topics: Adult; Antithyroid Agents; Collagen; Echocardiography; Electrocardiography; Female; Humans; Hyperthy | 2001 |