Page last updated: 2024-11-06

thyroxine and Carcinoma, Papillary, Follicular

thyroxine has been researched along with Carcinoma, Papillary, Follicular in 21 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Carcinoma, Papillary, Follicular: A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)

Research Excerpts

ExcerptRelevanceReference
"The development of hyponatremia during LT4 withdrawal and low-iodine diet in otherwise healthy patients with thyroid carcinoma is extremely rare."7.74Symptomatic hyponatremia in association with a low-iodine diet and levothyroxine withdrawal prior to I131 in patients with metastatic thyroid carcinoma. ( Clyde, PW; Hays, JH; Krook, LS; Schraml, FV; Shakir, MK, 2008)
"To evaluate cardiovascular functionality in patients with thyroid cancer, we have performed echocardiography and ambulatory blood pressure monitoring in 19 women with differentiated thyroid carcinoma during thyroxine withdrawal, at three time points: the last day on TSH-suppressive thyroxine doses (subclinical or mild hyperthyroidism), 4-7 days after withdrawal (normal free thyroxine (FT4) and free triiodothyronine (FT3) levels), and before 131I whole body scanning (overt hypothyroidism)."7.72Chronic thyrotropin-suppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with undesirable cardiovascular effects in patients with differentiated thyroid carcinoma. ( Barrios, V; Botella-Carretero, JI; Caballero, C; Escobar-Morreale, HF; García-Robles, R; Gómez-Bueno, M; Sancho, J, 2004)
"The development of hyponatremia during LT4 withdrawal and low-iodine diet in otherwise healthy patients with thyroid carcinoma is extremely rare."3.74Symptomatic hyponatremia in association with a low-iodine diet and levothyroxine withdrawal prior to I131 in patients with metastatic thyroid carcinoma. ( Clyde, PW; Hays, JH; Krook, LS; Schraml, FV; Shakir, MK, 2008)
"To evaluate cardiovascular functionality in patients with thyroid cancer, we have performed echocardiography and ambulatory blood pressure monitoring in 19 women with differentiated thyroid carcinoma during thyroxine withdrawal, at three time points: the last day on TSH-suppressive thyroxine doses (subclinical or mild hyperthyroidism), 4-7 days after withdrawal (normal free thyroxine (FT4) and free triiodothyronine (FT3) levels), and before 131I whole body scanning (overt hypothyroidism)."3.72Chronic thyrotropin-suppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with undesirable cardiovascular effects in patients with differentiated thyroid carcinoma. ( Barrios, V; Botella-Carretero, JI; Caballero, C; Escobar-Morreale, HF; García-Robles, R; Gómez-Bueno, M; Sancho, J, 2004)
"Differentiated thyroid carcinoma is the most common pediatric endocrine tumor, constituting 0."2.44Thyroid nodules and cancers in children. ( Josefson, J; Zimmerman, D, 2008)
"This is the second review article on thyroid cancer dealing with the common differentiated types that comprise 90% of thyroid cancers."2.43Thyroid cancer review 2: management of differentiated thyroid cancers. ( Coatesworth, AP; Nicolaides, A; Nix, P, 2005)
"More than 90% of primary thyroid cancers are differentiated papillary or follicular types."2.42Follow-up of differentiated thyroid carcinoma. ( Angellotti, G; Biondi, B; Klain, M; Lombardi, G; Pagano, L; Pasano, F; Pulcrano, M; Salvatore, M, 2004)
"Papillary and follicular thyroid cancer in childhood and adolescence is more advanced upon presentation than in adults, as evident from a higher frequency of extra-thyroidal spread."2.41Thyroid cancer in children and adolescents--consequences in later life. ( Wiersinga, WM, 2001)
"The prevalence of Hashimoto thyroiditis and NHLT in the 560 papillary thyroid cancer (PTC) patients was found to be 7."1.38Diagnostic value of antithyroid peroxidase antibody for incidental autoimmune thyroiditis based on histopathologic results. ( Hong, HP; Jung, SJ; Kang, T; Kim, DW; Kim, YW; Kwon, MJ; Park, YM; Rho, MH, 2012)
" After complete thyroidectomy and substitution with levothyroxine (l-T(4)), the preoperative, inadequately low T(4) and free T(4) remained, while increasing the l-T(4) dosage led to T(3) serum concentrations above the normal range."1.37Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy. ( Chiu-Ugalde, J; de Angelis, MH; Grüters, A; Klein, MO; Köhrle, J; Krude, H; Mossbrugger, I; Quintanilla-Martinez, L; Riebel, T; Rothe, K; Sapin, R; Schmid, KW; Schweizer, U; Sheu, SY; Wirth, EK, 2011)
"Insulin resistance is closely related to post-THW hypothyroidism in patients of DTC."1.35Factors related to clinical hypothyroid severity in thyroid cancer patients after thyroid hormone withdrawal. ( Chang, WD; Huang, SC; Lin, SY; Lin, YH; Sheu, WH; Song, YM; Wu, CC; Wu, VC, 2009)
"Optimal management of differentiated thyroid cancer in childhood is undetermined."1.33Importance of thyroglobulin levels for diagnosis and monitoring of follicular thyroid carcinoma in an adolescent with severe iodine deficiency. ( Adiyaman, P; Berberoğlu, M; Ergür, AT; Evliyaoğlu, O; Ocal, G; Sak, SD; Siklar, Z, 2006)
" If thyroglobulin remains undetectable during L-thyroxine treatment, an annual dosage is indicated and other exams are unwarranted."1.30[Papillary and follicular cancers of the thyroid]. ( Baudin, E; Schlumberger, M; Travagli, JP, 1998)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (9.52)18.2507
2000's15 (71.43)29.6817
2010's4 (19.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shakir, MK1
Krook, LS1
Schraml, FV1
Hays, JH1
Clyde, PW1
Josefson, J1
Zimmerman, D1
Huang, SC1
Wu, VC1
Lin, SY1
Sheu, WH1
Song, YM1
Lin, YH1
Wu, CC1
Chang, WD1
Emmanouilidis, N1
Müller, JA1
Jäger, MD1
Kaaden, S1
Helfritz, FA1
Güner, Z1
Kespohl, H1
Knitsch, W1
Knapp, WH1
Klempnauer, J1
Scheumann, GF1
Brassard, M1
Borget, I1
Edet-Sanson, A1
Giraudet, AL1
Mundler, O1
Toubeau, M1
Bonichon, F1
Borson-Chazot, F1
Leenhardt, L1
Schvartz, C1
Dejax, C1
Brenot-Rossi, I1
Toubert, ME1
Torlontano, M1
Benhamou, E1
Schlumberger, M3
Wirth, EK1
Sheu, SY1
Chiu-Ugalde, J1
Sapin, R1
Klein, MO1
Mossbrugger, I1
Quintanilla-Martinez, L1
de Angelis, MH1
Krude, H1
Riebel, T1
Rothe, K1
Köhrle, J1
Schmid, KW1
Schweizer, U1
Grüters, A1
Guerrissi, JO1
Rho, MH1
Kim, DW1
Hong, HP1
Park, YM1
Kwon, MJ1
Jung, SJ1
Kim, YW1
Kang, T1
Botella-Carretero, JI1
Gómez-Bueno, M1
Barrios, V1
Caballero, C1
García-Robles, R1
Sancho, J1
Escobar-Morreale, HF1
Pagano, L1
Klain, M1
Pulcrano, M1
Angellotti, G1
Pasano, F1
Salvatore, M1
Lombardi, G1
Biondi, B1
Nix, P1
Nicolaides, A1
Coatesworth, AP1
Chrisoulidou, A1
Pazaitou-Panayiotou, K1
Kaprara, A1
Platoyiannis, D1
Lafaras, C1
Boudina, M1
Georgiou, E1
Drimonitis, A1
Bischiniotis, T1
Vainas, I1
Siklar, Z1
Ocal, G1
Berberoğlu, M1
Adiyaman, P1
Ergür, AT1
Evliyaoğlu, O1
Sak, SD1
Dulgeroff, AJ1
Hershman, JM1
Baudin, E1
Travagli, JP1
Jarzab, B1
Handkiewicz Junak, D1
Włoch, J1
Kalemba, B1
Roskosz, J1
Kukulska, A1
Puch, Z1
Taniyama, M1
Ishikawa, N1
Momotani, N1
Ito, K1
Ban, Y1
de Keizer, B1
Koppeschaar, HP1
Zelissen, PM1
Lips, CJ1
van Rijk, PP1
van Dijk, A1
de Klerk, JM1
Wiersinga, WM1
Jones, MK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Multicenter, Open-label, Phase II Study of the Optimal Scheme of Administration of Pazopanib in Thyroid Carcinoma[NCT01813136]Phase 2168 participants (Actual)Interventional2013-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for thyroxine and Carcinoma, Papillary, Follicular

ArticleYear
Thyroid nodules and cancers in children.
    Pediatric endocrinology reviews : PER, 2008, Volume: 6, Issue:1

    Topics: Carcinoma, Medullary; Carcinoma, Papillary, Follicular; Child; Disease Susceptibility; Follow-Up Stu

2008
Follow-up of differentiated thyroid carcinoma.
    Minerva endocrinologica, 2004, Volume: 29, Issue:4

    Topics: Biomarkers, Tumor; Carcinoma, Papillary, Follicular; Humans; Iodine Radioisotopes; Sensitivity and S

2004
Thyroid cancer review 2: management of differentiated thyroid cancers.
    International journal of clinical practice, 2005, Volume: 59, Issue:12

    Topics: Carcinoma, Papillary; Carcinoma, Papillary, Follicular; Humans; Hypothyroidism; Neck; Thyroid Neopla

2005
[Papillary and follicular thyroid carcinoma].
    Annales d'endocrinologie, 2007, Volume: 68, Issue:2-3

    Topics: Carcinoma, Papillary; Carcinoma, Papillary, Follicular; Humans; Neoplasm Metastasis; Prognosis; Thyr

2007
Medical therapy for differentiated thyroid carcinoma.
    Endocrine reviews, 1994, Volume: 15, Issue:4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Papillary,

1994
Thyroid cancer in children and adolescents--consequences in later life.
    Journal of pediatric endocrinology & metabolism : JPEM, 2001, Volume: 14 Suppl 5

    Topics: Adolescent; Adult; Carcinoma, Medullary; Carcinoma, Papillary, Follicular; Child, Preschool; Humans;

2001

Trials

2 trials available for thyroxine and Carcinoma, Papillary, Follicular

ArticleYear
Surgery and radioablation therapy combined: introducing a 1-week-condensed procedure bonding total thyroidectomy and radioablation therapy with recombinant human TSH.
    European journal of endocrinology, 2009, Volume: 161, Issue:5

    Topics: Adult; Carcinoma, Papillary, Follicular; Cohort Studies; Combined Modality Therapy; Female; Humans;

2009
Efficacy of high therapeutic doses of iodine-131 in patients with differentiated thyroid cancer and detectable serum thyroglobulin.
    European journal of nuclear medicine, 2001, Volume: 28, Issue:2

    Topics: Adult; Aged; Carcinoma, Papillary, Follicular; Female; Follow-Up Studies; Humans; Iodine Radioisotop

2001

Other Studies

13 other studies available for thyroxine and Carcinoma, Papillary, Follicular

ArticleYear
Symptomatic hyponatremia in association with a low-iodine diet and levothyroxine withdrawal prior to I131 in patients with metastatic thyroid carcinoma.
    Thyroid : official journal of the American Thyroid Association, 2008, Volume: 18, Issue:7

    Topics: Aged; Aged, 80 and over; Aldosterone; Carcinoma, Papillary, Follicular; Diet; Female; Humans; Hypona

2008
Factors related to clinical hypothyroid severity in thyroid cancer patients after thyroid hormone withdrawal.
    Thyroid : official journal of the American Thyroid Association, 2009, Volume: 19, Issue:1

    Topics: Adult; Body Mass Index; Carcinoma, Papillary, Follicular; Cholesterol; Female; Homeostasis; Humans;

2009
Long-term follow-up of patients with papillary and follicular thyroid cancer: a prospective study on 715 patients.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Carcinoma, Papillary, Follicular; Cohort

2011
Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy.
    European journal of endocrinology, 2011, Volume: 165, Issue:4

    Topics: Animals; Blotting, Western; Carcinoma, Papillary, Follicular; Child; Electrophoresis, Polyacrylamide

2011
Follicular variant of papillary carcinoma in submandibular ectopic thyroid with no orthotopic thyroid gland.
    The Journal of craniofacial surgery, 2012, Volume: 23, Issue:1

    Topics: Adult; Carcinoma, Papillary, Follicular; Cell Transformation, Neoplastic; Choristoma; Diagnosis, Dif

2012
Diagnostic value of antithyroid peroxidase antibody for incidental autoimmune thyroiditis based on histopathologic results.
    Endocrine, 2012, Volume: 42, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Antibodies; Carcinoma, Papillary, Follicular; Female; Hashimoto D

2012
Chronic thyrotropin-suppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with undesirable cardiovascular effects in patients with differentiated thyroid carcinoma.
    Endocrine-related cancer, 2004, Volume: 11, Issue:2

    Topics: Adult; Blood Pressure; Carcinoma, Papillary, Follicular; Cardiovascular Diseases; Cell Differentiati

2004
Effects of thyroxine withdrawal in biochemical parameters and cardiac function and structure in patients with differentiated thyroid cancer.
    Minerva endocrinologica, 2006, Volume: 31, Issue:2

    Topics: Biomarkers; Carcinoma, Papillary, Follicular; Cardiovascular Diseases; Case-Control Studies; Creatin

2006
Importance of thyroglobulin levels for diagnosis and monitoring of follicular thyroid carcinoma in an adolescent with severe iodine deficiency.
    Journal of pediatric endocrinology & metabolism : JPEM, 2006, Volume: 19, Issue:9

    Topics: Adolescent; Antithyroid Agents; Biopsy; Carcinoma, Papillary, Follicular; Female; Goiter, Nodular; H

2006
[Papillary and follicular cancers of the thyroid].
    Presse medicale (Paris, France : 1983), 1998, Oct-03, Volume: 27, Issue:29

    Topics: Carcinoma, Papillary, Follicular; Follow-Up Studies; Humans; Iodine Radioisotopes; Lymph Node Excisi

1998
Multivariate analysis of prognostic factors for differentiated thyroid carcinoma in children.
    European journal of nuclear medicine, 2000, Volume: 27, Issue:7

    Topics: Adolescent; Carcinoma, Papillary, Follicular; Child; Disease-Free Survival; Female; Humans; Iodine R

2000
Toxic multinodular goitre in a patient with generalized resistance to thyroid hormone who harbours the R429Q mutation in the thyroid hormone receptor beta gene.
    Clinical endocrinology, 2001, Volume: 54, Issue:1

    Topics: Amino Acids; Biomarkers; Carcinoma, Papillary, Follicular; Female; Goiter, Nodular; Humans; Middle A

2001
Management of papillary and follicular thyroid cancer.
    Journal of the Royal Society of Medicine, 2002, Volume: 95, Issue:7

    Topics: Carcinoma, Papillary, Follicular; Humans; Iodine Radioisotopes; Risk Factors; Thyroglobulin; Thyroid

2002