thyroxine has been researched along with Carcinoma, Hepatocellular in 40 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study was to determine the effects of sorafenib on TH levels in patients with hepatocellular carcinoma (HCC) and to evaluate possible mechanisms." | 7.85 | Sorafenib-Induced Changes in Thyroid Hormone Levels in Patients Treated for Hepatocellular Carcinoma. ( Beukhof, CM; Bins, S; Chaker, L; de Herder, WW; de Rijke, YB; Mathijssen, RH; Peeters, RP; van Doorn, L; van Heerebeek, R; van Kemenade, FJ; Visser, TJ; Visser, WE, 2017) |
| "To determine the factors underlying the apparent reduction in binding ability of thyroxine-binding globulin in hepatocellular carcinoma, hormone-binding characteristics were further examined in patients with this disease and in control subjects." | 7.68 | Impaired binding properties of thyroxine-binding globulin in hepatocellular carcinoma and chronic liver disease. ( Fagan, EA; Hutchinson, WL; Johnson, PJ; White, YS; Williams, R, 1991) |
| "The objective of this study was to determine the effects of sorafenib on TH levels in patients with hepatocellular carcinoma (HCC) and to evaluate possible mechanisms." | 3.85 | Sorafenib-Induced Changes in Thyroid Hormone Levels in Patients Treated for Hepatocellular Carcinoma. ( Beukhof, CM; Bins, S; Chaker, L; de Herder, WW; de Rijke, YB; Mathijssen, RH; Peeters, RP; van Doorn, L; van Heerebeek, R; van Kemenade, FJ; Visser, TJ; Visser, WE, 2017) |
| " L-triiodothyronine and L-thyroxine stimulated hypoxia-induced Epo formation both in the kidney and in HepG2 cells in a dose-dependent fashion." | 3.69 | Thyroid hormones enhance hypoxia-induced erythropoietin production in vitro. ( Fandrey, J; Frede, S; Jelkmann, W; Pagel, H; Wolff, M, 1994) |
| "To determine the factors underlying the apparent reduction in binding ability of thyroxine-binding globulin in hepatocellular carcinoma, hormone-binding characteristics were further examined in patients with this disease and in control subjects." | 3.68 | Impaired binding properties of thyroxine-binding globulin in hepatocellular carcinoma and chronic liver disease. ( Fagan, EA; Hutchinson, WL; Johnson, PJ; White, YS; Williams, R, 1991) |
| "The significance of thyroxine (T4) uptake from serum in the assessment of thyroid status was evaluated, using human hepatoma (Hep G2) cells, in 30 euthyroid subjects, 6 hypothyroid and 19 hyperthyroid patients, and in 23 athyreotic cancer patients under T4 suppressive therapy." | 3.67 | Thyroxine uptake by human hepatoma cells from serum of patients submitted to long-term thyroxine suppressive therapy. ( Bartalena, L; Falcone, M; Martino, E; Pacchiarotti, A; Pinchera, A, 1988) |
| "During future treatment of hypothyroidism, close attention to liver function may also be required to prevent a possible increased risk of HCC." | 1.72 | Hypothyroidism has a protective causal association with hepatocellular carcinoma: A two-sample Mendelian randomization study. ( Li, L; Lu, L; Sun, M; Wan, B, 2022) |
| "In this study, a CBG secreting hepatocellular carcinoma derived cell line (HepG2) was used to investigate the hormonal regulation of hepatic CBG synthesis." | 1.33 | Hormonal effects on the secretion and glycoform profile of corticosteroid-binding globulin. ( Ali, SO; Lewis, JG; Mihrshahi, R, 2006) |
| "It is postulated that this patient's hepatoma produced a substance stimulating thyroid-stimulating hormone synthesis and secretion with resultant inappropriate thyroid-stimulating hormone production and thyrotoxicosis." | 1.27 | Hepatocellular carcinoma: an unusual course with hyperthyroidism and inappropriate thyroid-stimulating hormone production. ( Helzberg, JH; Lukert, BP; McPhee, MS; Zarling, EJ, 1985) |
| "Similarly, the presence or absence of hepatic encephalopathy determined, and/or reflected, at least in part, the type of response observed." | 1.27 | Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease. ( Gavaler, JS; Sanghvi, A; Schade, RR; Tarter, R; Van Thiel, DH, 1986) |
| "Three cases of hepatocellular carcinoma are reported in young men who had been taking androgenic-anabolic steroids." | 1.25 | Androgen-induced hepatoma. ( Baird, PJ; Farrell, GC; Joshua, DE; Kronenberg, H; Perkins, KW; Uren, RF, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (60.00) | 18.7374 |
| 1990's | 7 (17.50) | 18.2507 |
| 2000's | 4 (10.00) | 29.6817 |
| 2010's | 4 (10.00) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, L | 1 |
| Wan, B | 1 |
| Li, L | 2 |
| Sun, M | 1 |
| Beukhof, CM | 1 |
| van Doorn, L | 1 |
| Visser, TJ | 1 |
| Bins, S | 1 |
| Visser, WE | 1 |
| van Heerebeek, R | 1 |
| van Kemenade, FJ | 1 |
| de Rijke, YB | 1 |
| de Herder, WW | 1 |
| Chaker, L | 1 |
| Mathijssen, RH | 1 |
| Peeters, RP | 1 |
| P Katare, D | 1 |
| Malik, S | 1 |
| J Mani, R | 1 |
| Ranjpour, M | 1 |
| Jain, SK | 1 |
| Chi, JL | 1 |
| Li, CC | 1 |
| Xia, CQ | 1 |
| Ma, Y | 1 |
| Li, JH | 1 |
| Chen, Z | 1 |
| Chen, XL | 1 |
| Schmohl, KA | 1 |
| Müller, AM | 1 |
| Wechselberger, A | 1 |
| Rühland, S | 1 |
| Salb, N | 1 |
| Schwenk, N | 1 |
| Heuer, H | 1 |
| Carlsen, J | 1 |
| Göke, B | 1 |
| Nelson, PJ | 1 |
| Spitzweg, C | 1 |
| Baginskaya, NV | 1 |
| Il'nitskaya, SI | 1 |
| Nikitenko, EV | 1 |
| Kaledin, VI | 1 |
| Araya, Z | 1 |
| Tang, W | 1 |
| Wikvall, K | 1 |
| EMMELOT, P | 1 |
| BOS, CJ | 1 |
| BIELSCHOWSKY, F | 1 |
| BIELSCHOWSKY, M | 1 |
| FLETCHER, EK | 1 |
| LU, KH | 1 |
| YUAN, CC | 1 |
| WANG, PY | 1 |
| Mihrshahi, R | 1 |
| Lewis, JG | 1 |
| Ali, SO | 1 |
| Rosner, W | 1 |
| Aden, DP | 2 |
| Khan, MS | 1 |
| Ordóñez-Llanos, J | 1 |
| Rodríguez-Espinosa, J | 1 |
| Gómez-Gerique, JA | 1 |
| Fandrey, J | 3 |
| Pagel, H | 1 |
| Frede, S | 1 |
| Wolff, M | 1 |
| Jelkmann, W | 3 |
| Kragie, L | 1 |
| Forrester, ML | 1 |
| Cody, V | 1 |
| McCourt, M | 1 |
| Brenner, B | 1 |
| Benvenga, S | 1 |
| Lakshmanan, M | 1 |
| Trimarchi, F | 1 |
| Farrell, GC | 1 |
| Joshua, DE | 1 |
| Uren, RF | 1 |
| Baird, PJ | 1 |
| Perkins, KW | 1 |
| Kronenberg, H | 1 |
| Belanger, L | 1 |
| Hamel, D | 1 |
| Lachance, L | 1 |
| Dufour, D | 1 |
| Tremblay, M | 1 |
| Gagnon, PM | 1 |
| Sorimachi, K | 1 |
| Robbins, J | 1 |
| Hutchinson, WL | 1 |
| White, YS | 1 |
| Fagan, EA | 1 |
| Johnson, PJ | 1 |
| Williams, R | 1 |
| Darby, IA | 1 |
| Bouhnik, J | 1 |
| Coezy, ED | 1 |
| Corvol, P | 1 |
| Seydel, FP | 1 |
| Siegers, CP | 1 |
| Plymate, SR | 2 |
| Hoop, RC | 1 |
| Jones, RE | 2 |
| Matej, LA | 2 |
| Kobayashi, M | 1 |
| Horiuchi, R | 1 |
| Hachisu, T | 1 |
| Takikawa, H | 1 |
| Friedl, KE | 1 |
| Bartalena, L | 1 |
| Martino, E | 1 |
| Falcone, M | 1 |
| Pacchiarotti, A | 1 |
| Pinchera, A | 1 |
| Helzberg, JH | 1 |
| McPhee, MS | 1 |
| Zarling, EJ | 1 |
| Lukert, BP | 1 |
| Murata, Y | 1 |
| Sarne, DH | 1 |
| Horwitz, AL | 1 |
| Lecocq, R | 1 |
| Knowles, BB | 1 |
| Refetoff, S | 1 |
| Van Thiel, DH | 1 |
| Tarter, R | 1 |
| Gavaler, JS | 1 |
| Schade, RR | 1 |
| Sanghvi, A | 1 |
| Hamada, S | 1 |
| Nakagawa, T | 1 |
| Mori, T | 1 |
| Torizuka, K | 1 |
| Goodall, CM | 1 |
| Bellabarba, D | 1 |
| Inada, M | 1 |
| Varsano-Aharon, N | 1 |
| Sterling, K | 1 |
| Arcos, JC | 1 |
| Mathison, JB | 1 |
| Tison, MJ | 1 |
| Mouledoux, AM | 1 |
| Saliamon, LS | 1 |
| Wu, C | 1 |
| Morris, HP | 1 |
| Herzfeld, A | 1 |
| Greengard, O | 2 |
| Chandalia, HB | 1 |
| Boshell, BR | 1 |
| Dewey, HK | 1 |
| Pedersen, OL | 1 |
40 other studies available for thyroxine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Hypothyroidism has a protective causal association with hepatocellular carcinoma: A two-sample Mendelian randomization study.
Topics: Carcinoma, Hepatocellular; Genome-Wide Association Study; Humans; Hypothyroidism; Liver Neoplasms; M | 2022 |
Sorafenib-Induced Changes in Thyroid Hormone Levels in Patients Treated for Hepatocellular Carcinoma.
Topics: Aged; Amino Acid Transport Systems, Neutral; Animals; Antineoplastic Agents; Carcinoma, Hepatocellul | 2017 |
Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Apolipoprotein A-I; Biomarkers, Tumor; Carcinom | 2018 |
Effect of (131)I gelatin microspheres on hepatocellular carcinoma in nude mice and its distribution after intratumoral injection.
Topics: Animals; Carcinoma, Hepatocellular; Gelatin; Hep G2 Cells; Heterografts; Humans; Injections, Intrale | 2014 |
Thyroid hormones and tetrac: new regulators of tumour stroma formation via integrin αvβ3.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Differentia | 2015 |
Promoting effect of o-aminoazotoluene on hepatocarcinogenesis is accompanied by the increase in inflammatory and proliferative processes in liver tissue and decrease in the concentration of free thyroxin in the blood.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Female; Inf | 2007 |
Hormonal regulation of the human sterol 27-hydroxylase gene CYP27A1.
Topics: Antineoplastic Agents, Hormonal; Base Sequence; Binding Sites; Carcinogens; Carcinoma, Hepatocellula | 2003 |
The effect of thyroxine on the swelling of mitochondria isolated from normal and neoplastic livers.
Topics: Animals; Carcinoma, Hepatocellular; Humans; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; M | 1957 |
Investigations on the role of thyroxine in the development of hepatomas in hypophysectomized rats and pituitary dwarf mice.
Topics: Animals; Carcinoma, Hepatocellular; Dwarfism; Dwarfism, Pituitary; Hypophysectomy; Liver Neoplasms; | 1962 |
[THE EFFECT OF THYROXINE ON ISOLATED MITOCHONDRIA OF RAT LIVER AND HEPATOMA].
Topics: Adenosine Triphosphatases; Carcinoma, Hepatocellular; Enzyme Inhibitors; Liver; Liver Neoplasms; Met | 1964 |
Hormonal effects on the secretion and glycoform profile of corticosteroid-binding globulin.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Dexamethasone; Electrophoresis, Gel, Two-Dimensional; E | 2006 |
Hormonal influences on the secretion of steroid-binding proteins by a human hepatoma-derived cell line.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cytosol; Estradiol; Humans; Liver; Liver Neoplasms; R | 1984 |
Antibody binding serum T3 in a patient with hepatocarcinoma.
Topics: Aged; Carcinoma, Hepatocellular; Humans; Immunoglobulins; Liver Neoplasms; Male; Protein Binding; Ra | 1984 |
Thyroid hormones enhance hypoxia-induced erythropoietin production in vitro.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Cells, Cultured; DNA; Dose-Response Relation | 1994 |
Computer-assisted molecular modeling of benzodiazepine and thyromimetic inhibitors of the HepG2 iodothyronine membrane transporter.
Topics: Benzodiazepines; Biological Transport; Carcinoma, Hepatocellular; Cell Membrane; Humans; Image Proce | 1994 |
Serum immunoreactive erythropoietin in hyper- and hypothyroidism: clinical observations related to cell culture studies.
Topics: Carcinoma, Hepatocellular; Erythropoietin; Hemoglobins; Humans; Hyperthyroidism; Hypothyroidism; Liv | 1994 |
Carnitine is a naturally occurring inhibitor of thyroid hormone nuclear uptake.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carcinoma, Hepatocellular; Carnitine; Cell Line | 2000 |
Androgen-induced hepatoma.
Topics: Adult; Anabolic Agents; Bone Neoplasms; Carcinoma, Hepatocellular; Cortisone; Cryptorchidism; Hemogl | 1975 |
Hormonal regulation of alpha1 foetoprotein.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Depression, Chemical; DNA; Epinephrine; Feta | 1975 |
Metabolism of thyroid hormones by cultured monkey hepatocarcinoma cells. Nonphenolic ring dieodination and sulfation.
Topics: Carcinoma, Hepatocellular; Cell Line; Chromatography, Ion Exchange; Chromatography, Thin Layer; Hydr | 1977 |
Impaired binding properties of thyroxine-binding globulin in hepatocellular carcinoma and chronic liver disease.
Topics: Adult; Carcinoma, Hepatocellular; Chronic Disease; Cytosol; Humans; Liver Diseases; Liver Neoplasms; | 1991 |
Thyroid hormone receptors and stimulation of angiotensinogen production in HepG2 cells.
Topics: Angiotensinogen; Binding, Competitive; Carcinoma, Hepatocellular; Cell Line; Cell Nucleus; Humans; K | 1991 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoi | 1990 |
Regulation of sex hormone-binding globulin production by growth factors.
Topics: Carcinoma, Hepatocellular; Cell Line; Dehydroepiandrosterone; Epidermal Growth Factor; Growth Substa | 1990 |
Dualistic effects of thyroid hormone on a human hepatoma cell line: inhibition of thyroxine-binding globulin synthesis and stimulation of alpha 1-acid glycoprotein synthesis.
Topics: Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Humans; Kinetics; Liver Neoplasms; Orosomucoid; | 1988 |
Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.
Topics: Carcinoma, Hepatocellular; Cell Line; Depression, Chemical; Estradiol; Humans; Insulin; Liver Neopla | 1988 |
Thyroxine uptake by human hepatoma cells from serum of patients submitted to long-term thyroxine suppressive therapy.
Topics: Carcinoma, Hepatocellular; Humans; Hyperthyroidism; Hypothyroidism; Liver Neoplasms; Sex Hormone-Bin | 1988 |
Hepatocellular carcinoma: an unusual course with hyperthyroidism and inappropriate thyroid-stimulating hormone production.
Topics: Carcinoma, Hepatocellular; Female; Humans; Hyperthyroidism; Liver Neoplasms; Middle Aged; Paraneopla | 1985 |
Characterization of thyroxine-binding globulin secreted by a human hepatoma cell line.
Topics: Carcinoma, Hepatocellular; Cell Line; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Humans; | 1985 |
Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease.
Topics: Carcinoma, Hepatocellular; Growth Hormone; Hepatic Encephalopathy; Humans; Liver Diseases; Liver Neo | 1986 |
Re-evaluation of thyroxine binding and free thyroxine in human serum by paper electrophoresis and equilibrium dialysis, and a new free thyroxine index.
Topics: Anorexia Nervosa; Carcinoma, Hepatocellular; Diabetes Mellitus; Dialysis; Electrophoresis; Female; G | 1970 |
Hepatic carcinogenesis in thyroidectomized rats: apparent blockade at the stage of initiation.
Topics: Animals; Carcinoma, Hepatocellular; Cortisone; Fluorenes; Liver Neoplasms; Neoplasms, Experimental; | 1966 |
Thyroxine transport and turnover in major nonthyroidal illness.
Topics: Adenocarcinoma; Adult; Aged; Biological Transport; Blood Proteins; Carcinoma; Carcinoma, Bronchogeni | 1968 |
Effect of feeding amino azo dyes on mitochondrial swelling and contraction. Kinetic evidence for deletion of membrane regulatory sites.
Topics: Adenosine Triphosphate; Animals; Arsenic; Carcinoma, Hepatocellular; Cell Membrane; Chloromercuriben | 1969 |
[Analysis of tumor transformation of tissue. I. Indications of the degree of autonomy and their appearance].
Topics: Adenoma; Adenosine Triphosphate; Animals; Breast Neoplasms; Carcinogens; Carcinoma, Hepatocellular; | 1969 |
Responsiveness of glutamine-metabolizing enzymes in Morris hepatomas to metabolic modulations.
Topics: Adrenalectomy; Animal Feed; Animals; Animals, Laboratory; Carcinoma, Hepatocellular; Cell Line; Chro | 1970 |
Aspartate aminotransferase in fat tissues: changes with growth and hormones.
Topics: Aging; Animals; Aspartate Aminotransferases; Brain; Breast; Carcinoma 256, Walker; Carcinoma, Hepato | 1971 |
Hypoglycemia associated with extrapancreatic tumors. Report of two cases with studies on its pathogenesis.
Topics: Abdominal Neoplasms; Aged; Animals; Biological Assay; Blood Glucose; Carcinoma, Hepatocellular; Fatt | 1972 |
The effect of glucose ingestion on basal and induced enzyme levels in rat tissues.
Topics: Adrenal Glands; Adrenalectomy; Amino Acids; Animals; Brain; Carcinoma, Hepatocellular; Dietary Carbo | 1973 |
[Primary hepatocellular carcinoma with increased TBG and free thyroxine].
Topics: Aged; Carcinoma, Hepatocellular; Female; Humans; Immunoelectrophoresis; Liver Neoplasms; Radioimmuno | 1974 |