thyroxine has been researched along with Brain Dead in 34 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Deterioration of function in brain dead baboons is associated with depletion of both myocardial energy stores and certain circulating hormones, notably thyroxine, cortisol, and insulin." | 3.67 | Improved cardiac function following hormonal therapy in brain dead pigs: relevance to organ donation. ( Cooper, DK; Novitzky, D; Tjaalgard, MA; Wicomb, WN, 1987) |
| "87) as was vasopressor dosage (6 vs 12 μg/min of norepinephrine, NE, P = 0." | 2.90 | A randomized trial comparing triiodothyronine (T3) with thyroxine (T4) for hemodynamically unstable brain-dead organ donors. ( Dhar, R; Marklin, G; Stahlschmidt, E; Yan, Y, 2019) |
| "LT before the declaration of brain death was initiated in 37 patients compared with 40 patients who had it started after the declaration of brain death." | 1.40 | Levothyroxine therapy before brain death declaration increases the number of solid organ donations. ( Aziz, H; Friese, RS; Green, DJ; Joseph, B; Kulvatunyou, N; O'Keeffe, T; Pandit, V; Rhee, P; Sadoun, M; Tang, A, 2014) |
| "Brain death was caused in young pigs (25-38 kg) by rapid inflation of an intracranially implanted balloon catheter." | 1.29 | The influence of thyroid hormone replacement in a porcine brain death model. ( Bird, S; Hickman, R; Innes, CR; Lotz, Z; Schwartz, I, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.82) | 18.7374 |
| 1990's | 7 (20.59) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 10 (29.41) | 24.3611 |
| 2020's | 6 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Dhar, R | 4 |
| Klinkenberg, D | 1 |
| Marklin, G | 4 |
| Van Bakel, AB | 1 |
| Hino, SA | 1 |
| Welker, D | 1 |
| Morella, K | 1 |
| Gregoski, MJ | 1 |
| Craig, ML | 1 |
| Crumbley, AJ | 1 |
| Sade, RM | 1 |
| Marklin, GF | 1 |
| Klinkenberg, WD | 1 |
| Wang, J | 1 |
| Goss, CW | 1 |
| Lele, AV | 1 |
| Kensinger, CD | 1 |
| Lange, PA | 1 |
| Lebovitz, DJ | 1 |
| Bourgeois, A | 1 |
| Magazzeni, P | 1 |
| Audibert, G | 1 |
| Stahlschmidt, E | 2 |
| Bery, A | 1 |
| Itoh, A | 1 |
| Kreisel, D | 1 |
| Takahashi, T | 1 |
| Meyers, BF | 1 |
| Nava, R | 1 |
| Kozower, BD | 1 |
| Shepherd, H | 1 |
| Patterson, GA | 1 |
| Puri, V | 1 |
| Akbaş, T | 1 |
| Sahin, İE | 1 |
| Ozturk, A | 1 |
| Chacon, MM | 1 |
| Markin, NW | 1 |
| Yan, Y | 1 |
| Frenette, AJ | 1 |
| Williamson, D | 1 |
| Williams, V | 1 |
| Lagacé, AM | 1 |
| Charbonney, E | 1 |
| Serri, K | 1 |
| Joseph, B | 1 |
| Aziz, H | 1 |
| Pandit, V | 1 |
| Kulvatunyou, N | 1 |
| Sadoun, M | 1 |
| Tang, A | 1 |
| O'Keeffe, T | 1 |
| Green, DJ | 1 |
| Friese, RS | 1 |
| Rhee, P | 1 |
| Novitzky, D | 5 |
| Mi, Z | 2 |
| Sun, Q | 1 |
| Collins, JF | 2 |
| Cooper, DK | 5 |
| Wicomb, W | 1 |
| Abdelnour, T | 1 |
| Rieke, S | 1 |
| Nath, DS | 1 |
| Ilias Basha, H | 1 |
| Liu, MH | 1 |
| Moazami, N | 1 |
| Ewald, GA | 1 |
| Macdonald, PS | 1 |
| Aneman, A | 1 |
| Bhonagiri, D | 1 |
| Jones, D | 1 |
| O'Callaghan, G | 1 |
| Silvester, W | 1 |
| Watson, A | 1 |
| Dobb, G | 1 |
| Steen, S | 1 |
| Sjöberg, T | 1 |
| Liao, Q | 1 |
| Bozovic, G | 1 |
| Wohlfart, B | 1 |
| Rosendale, JD | 2 |
| Kauffman, HM | 2 |
| McBride, MA | 2 |
| Chabalewski, FL | 2 |
| Zaroff, JG | 2 |
| Garrity, ER | 2 |
| Delmonico, FL | 2 |
| Rosengard, BR | 2 |
| Phongsamran, PV | 1 |
| Zuppa, AF | 1 |
| Nadkarni, V | 2 |
| Davis, L | 1 |
| Adamson, PC | 1 |
| Helfaer, MA | 1 |
| Elliott, MR | 1 |
| Abrams, J | 1 |
| Durbin, D | 1 |
| Mariot, J | 1 |
| Sadoune, LO | 1 |
| Jacob, F | 1 |
| Dousset, B | 1 |
| Perrier, JF | 1 |
| Jacob, C | 1 |
| Strub, P | 1 |
| Voltz, C | 1 |
| García-Fages, LC | 1 |
| Cabrer, C | 1 |
| Valero, R | 1 |
| Manyalich, M | 1 |
| Schwartz, I | 1 |
| Bird, S | 1 |
| Lotz, Z | 1 |
| Innes, CR | 1 |
| Hickman, R | 1 |
| Colpart, JJ | 1 |
| Ramella, S | 1 |
| Bret, M | 1 |
| Coronel, B | 1 |
| Dorez, D | 1 |
| Mercatello, A | 1 |
| Hadj Aissa, A | 1 |
| Moskovtchenko, JF | 1 |
| Yoshida, H | 1 |
| Hiraide, A | 1 |
| Iwai, A | 1 |
| Kawaguchi, N | 1 |
| Yoshioka, T | 1 |
| Sugimoto, T | 1 |
| Szostek, M | 1 |
| Gaciong, Z | 1 |
| Cajzner, S | 1 |
| Lagiewska, B | 1 |
| Pacholczyk, M | 1 |
| Wałaszewski, J | 1 |
| Rowiński, W | 1 |
| Katz, K | 1 |
| Lawler, J | 1 |
| Wax, J | 1 |
| O'Connor, R | 1 |
| Salim, A | 1 |
| Vassiliu, P | 1 |
| Velmahos, GC | 1 |
| Sava, J | 1 |
| Murray, JA | 1 |
| Belzberg, H | 1 |
| Asensio, JA | 1 |
| Demetriades, D | 1 |
| Koller, J | 1 |
| Wieser, C | 1 |
| Gottardis, M | 1 |
| Kornberger, R | 1 |
| Furtwängler, W | 1 |
| Königsrainer, A | 1 |
| Margreiter, R | 1 |
| Robertson, KM | 1 |
| Hramiak, IM | 1 |
| Gelb, AW | 1 |
| Wicomb, WN | 2 |
| Tjaalgard, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter Randomized Placebo-Controlled Trial of Intravenous Thyroxine for Heart-Eligible Brain Dead Organ Donors[NCT04415658] | Phase 3 | 840 participants (Actual) | Interventional | 2020-12-01 | Completed | ||
| Cadaveric Organ Donor Management: Thyroid and Adrenocortical Hormone Replacement[NCT04528797] | 199 participants (Actual) | Interventional | 2010-09-02 | Completed | |||
| Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controlled Trial[NCT02211053] | Phase 4 | 15 participants (Actual) | Interventional | 2014-07-31 | Terminated (stopped due to Recruitment was too slow and we cannot anticipate to recruit the target sample size) | ||
| "Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by the Funny Channel Current (If) Inhibitor Ivabradine"[NCT01186783] | Phase 2 | 70 participants (Anticipated) | Interventional | 2010-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thyroxine and Brain Dead
| Article | Year |
|---|---|
Specialized Donor Care Facility Model and Advances in Management of Thoracic Organ Donors.
Topics: Brain Death; Glucocorticoids; Heart Transplantation; Humans; Prospective Studies; Retrospective Stud | 2022 |
A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors.
Topics: Brain Death; Humans; Randomized Controlled Trials as Topic; Thyroid Hormones; Thyroxine; Tissue Dono | 2012 |
Critical care pharmacy in donor management.
Topics: Adrenal Cortex Hormones; Brain Death; Clinical Protocols; Critical Care; Critical Pathways; Drug Adm | 2004 |
6 trials available for thyroxine and Brain Dead
| Article | Year |
|---|---|
A multicenter randomized placebo-controlled trial of intravenous thyroxine for heart-eligible brain-dead organ donors.
Topics: Brain; Brain Death; Humans; Thyroxine; Tissue and Organ Procurement; Tissue Donors | 2021 |
Hemodynamic Effects of High-dose Levothyroxine and Methylprednisolone in Brain-dead Potential Organ Donors.
Topics: Adult; Brain; Brain Death; Hemodynamics; Humans; Methylprednisolone; Thyroxine; Tissue and Organ Pro | 2022 |
Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors.
Topics: Administration, Intravenous; Brain; Brain Death; Heart Transplantation; Hemodynamics; Humans; Thyrox | 2023 |
A Randomized Trial of Intravenous Thyroxine for Brain-Dead Organ Donors With Impaired Cardiac Function.
Topics: Adult; Brain Death; Female; Heart Transplantation; Humans; Infusions, Intravenous; Male; Middle Aged | 2020 |
A randomized trial comparing triiodothyronine (T3) with thyroxine (T4) for hemodynamically unstable brain-dead organ donors.
Topics: Adult; Brain Death; Female; Follow-Up Studies; Heart Transplantation; Hemodynamics; Humans; Male; Or | 2019 |
A Pilot Randomized Controlled Trial Comparing Levothyroxine to Placebo in Neurologically Deceased Donors.
Topics: Adult; Brain Death; Brain Injuries, Traumatic; Double-Blind Method; Echocardiography; Feasibility St | 2019 |
25 other studies available for thyroxine and Brain Dead
| Article | Year |
|---|---|
Left ventricular failure after brain death: a room for L-thyroxine?
Topics: Accidents, Traffic; Brain Death; Brain Injuries; Cardiac Output; Humans; Male; Thyroxine; Tissue and | 2020 |
Alterations in thyroid hormones in brain-dead patients are related to non-thyroidal illness syndrome.
Topics: Adult; Aged; Brain Death; Euthyroid Sick Syndromes; Female; Humans; Male; Middle Aged; Thyrotropin; | 2018 |
Thyroid Hormone Replacement in Brain-Dead Organ Donor: Should it Be Standard of Care or Is it Still too Soon to Tell?
Topics: Brain; Brain Death; Heart Transplantation; Humans; Standard of Care; Thyroxine; Tissue Donors | 2019 |
Levothyroxine therapy before brain death declaration increases the number of solid organ donations.
Topics: Adult; Analysis of Variance; Brain Death; Cardiopulmonary Resuscitation; Cohort Studies; Drug Admini | 2014 |
Thyroid hormone therapy in the management of 63,593 brain-dead organ donors: a retrospective analysis.
Topics: Adolescent; Adult; Brain Death; Female; Graft Survival; Humans; Male; Middle Aged; Multivariate Anal | 2014 |
Increased Procurement of Thoracic Donor Organs After Thyroid Hormone Therapy.
Topics: Adult; Brain Death; Chi-Square Distribution; Donor Selection; Female; Graft Survival; Heart Transpla | 2015 |
Hormonal therapy to the brain-dead potential organ donor: the misnomer of the "Papworth cocktail".
Topics: Brain Death; Drug Therapy, Combination; Fatty Liver; Hormones; Humans; Liver; Methylprednisolone; Te | 2008 |
Relationship of hormonal resuscitation therapy and central venous pressure on increasing organs for transplant.
Topics: Adolescent; Adult; Brain Death; Central Venous Pressure; Child; Female; Glucocorticoids; Heart Trans | 2009 |
Increased recovery of thoracic organs after hormonal resuscitation therapy.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Brain Death; Cause of Death; Child; Cold Ischemia; Fema | 2010 |
Pharmacological normalization of circulation after acute brain death.
Topics: Anesthesia; Animals; Arterial Pressure; Blood Circulation; Blood Gas Analysis; Blood Pressure; Body | 2012 |
Aggressive pharmacologic donor management results in more transplanted organs.
Topics: Adult; Brain Death; Child; Child, Preschool; Humans; Middle Aged; Multivariate Analysis; Renal Agent | 2003 |
Hormonal resuscitation yields more transplanted hearts, with improved early function.
Topics: Adult; Brain Death; Female; Glucocorticoids; Heart; Heart Transplantation; Hormones; Humans; Male; M | 2003 |
The effect of a thyroid hormone infusion on vasopressor support in critically ill children with cessation of neurologic function.
Topics: Adolescent; Brain Death; Child; Child, Preschool; Confounding Factors, Epidemiologic; Critical Illne | 2004 |
Hormone levels, hemodynamics, and metabolism in brain dead organ donors.
Topics: Age Factors; Blood Pressure; Brain Death; Cardiac Output; Central Venous Pressure; Diuresis; Female; | 1995 |
Hemodynamic and metabolic effects of substitutive triiodothyronine therapy in organ donors.
Topics: Adenine Nucleotides; Blood Pressure; Body Temperature; Brain Death; Heart Rate; Hemodynamics; Humans | 1993 |
The influence of thyroid hormone replacement in a porcine brain death model.
Topics: Animals; Brain Death; Disease Models, Animal; Hemodynamics; Liver; Liver Transplantation; Swine; Thy | 1993 |
Hypophysis-thyroid axis disturbances in human brain-dead donors.
Topics: Brain Death; Humans; Pituitary Gland, Anterior; Thyroid Gland; Thyrotropin; Thyroxine; Tissue Donors | 1996 |
Preservation of pancreatic endocrine function by hemodynamic stabilization following brain death.
Topics: Adrenergic Agonists; Adult; Blood Circulation; Blood Glucose; Blood Pressure; Brain Death; Epinephri | 1997 |
The effect of endocrine disturbances on hemodynamic stability of brain dead organ donors. I. Thyroid function.
Topics: Adolescent; Adult; Blood Pressure; Brain Death; Female; Hemodynamics; Humans; Kidney Transplantation | 1996 |
Vasopressin pressor effects in critically ill children during evaluation for brain death and organ recovery.
Topics: Adolescent; Blood Pressure; Brain Death; Cardiotonic Agents; Case-Control Studies; Child; Child, Pre | 2000 |
The role of thyroid hormone administration in potential organ donors.
Topics: Adult; Brain Death; Female; Hemodynamics; Humans; Male; Organ Preservation; Prospective Studies; Res | 2001 |
Thyroid hormones and their impact on the hemodynamic and metabolic stability of organ donors and on kidney graft function after transplantation.
Topics: Adult; Biomarkers; Blood Pressure; Brain Death; Female; Heart Rate; Hemodynamics; HLA Antigens; Huma | 1990 |
Endocrine changes and haemodynamic stability after brain death.
Topics: Adult; Brain Death; Female; Hemodynamics; Humans; Hydrocortisone; Male; Thyrotropin; Thyroxine; Tiss | 1989 |
Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy.
Topics: Animals; Blood Pressure; Brain Death; Brain Ischemia; Cold Temperature; Hydrocortisone; Insulin; Kid | 1986 |
Improved cardiac function following hormonal therapy in brain dead pigs: relevance to organ donation.
Topics: Animals; Brain Death; Heart; Hot Temperature; Humans; In Vitro Techniques; Insulin; Perfusion; Swine | 1987 |