Page last updated: 2024-11-06

thyroxine and Atherogenesis

thyroxine has been researched along with Atherogenesis in 50 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
" The aim of this study was to investigate the concentration of plasma soluble intercellular adhesion molecule-1 and adiponectin in relation to insulin sensitivity in patients with subclinical hypothyroidism and to estimate if L-thyroxine treatment had an influence on these parameters."9.15Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy. ( Borawski, J; Budlewski, T; Górska, M; Kowalska, I; Nikołajuk, A; Otziomek, E; Strączkowski, M, 2011)
" Since thyroid hormones may mediate the association between ARG derivatives and atherosclerosis, this study investigated whether asymmetric and symmetric dimethylarginines (ADMA and SDMA, respectively) as well as homoarginine (hARG) are associated with parameters of thyroid function in the general population."7.83L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population. ( Atzler, D; Bahls, M; Böger, RH; Dörr, M; Felix, SB; Friedrich, N; Ittermann, T; Schwedhelm, E; Völzke, H, 2016)
"To investigate the effect of levothyroxine (L-T4) treatment on early markers of atherosclerotic disease in children with mild idiopathic subclinical hypothyroidism (SH)."7.83Effects of L-thyroxine treatment on early markers of atherosclerotic disease in children with subclinical hypothyroidism. ( Alfano, S; Capalbo, D; Cerbone, M; Cittadini, A; De Luca, F; Mattace Raso, G; Oliviero, U; Salerno, M; Wasniewska, M, 2016)
" We aimed to explore the changes in atherosclerotic risk factors and insulin sensitivity before and after levothyroxine replacement therapy in women with primary hypothyroidism and compare with that of healthy controls."7.80Effects of levothyroxine treatment on insulin sensitivity, endothelial function and risk factors of atherosclerosis in hypothyroid women. ( Akalın, NS; Akpınar, IN; Deyneli, O; Gözü, H; Meriçliler, OS; Yıldız, ME, 2014)
" We hypothesized that L-thyroxine replacement therapy might be able to reverse the process associated with increase in CIMT in patients with primary hypothyroidism."7.75Effects of L-thyroxine replacement therapy on carotid intima-media thickness in patients with primary hypothyroidism. ( Aral, Y; Cakal, B; Cakal, E; Demirbas, B; Ozkaya, M; Serter, R; Turgut, AT, 2009)
"Hypothyroidism is a common endocrine disorder and requires lifelong treatment."5.91Impact of Levothyroxine on Lipid Profile in Patients with Hypothyroidism. ( Ara, S; Islam, MN; Moni, SY; Rahman, FB; Sultana, Z; Zubery, MH, 2023)
"Subclinical hypothyroidism (SHypo) has been associated with atherosclerosis, but no conclusive clinical trials assessing the levothyroxine impact on carotid atherosclerosis exist."5.27Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial. ( Adam, L; Bauer, DC; Blum, MR; Collet, TH; da Costa, BR; Depairon, M; Dopheide, J; Feller, M; Gencer, B; Gussekloo, J; Kearney, P; Moutzouri, E; Rodondi, N; Stott, DJ; Sykiotis, GP; Westendorp, R, 2018)
" The aim of this study was to investigate the concentration of plasma soluble intercellular adhesion molecule-1 and adiponectin in relation to insulin sensitivity in patients with subclinical hypothyroidism and to estimate if L-thyroxine treatment had an influence on these parameters."5.15Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy. ( Borawski, J; Budlewski, T; Górska, M; Kowalska, I; Nikołajuk, A; Otziomek, E; Strączkowski, M, 2011)
"Many studies have found clinical and metabolic alterations in subclinical hypothyroidism, however, there are disagreements about the benefits of levothyroxine therapy."5.13Treatment of subclinical hypothyroidism reduces atherogenic lipid levels in a placebo-controlled double-blind clinical trial. ( Almeida, CP; Buescu, A; Costa, AJ; Ferreira, MM; Melo, BA; Reis, FA; Reuters, VS; Teixeira, PF; Vaisman, M, 2008)
"We expanded the data on cIMT in young women with T1DM and showed that thyroid autoimmunity, and in particular the duration of exposure to anti-thyroid antibodies, despite adequate levothyroxine substitution, is associated with subclinical atherosclerosis in young women with T1DM."4.12[Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?] ( Czupryniak, L; Franek, E; Mrozikiewicz-Rakowska, B; Zieliński, J; Łukawska-Tatarczuk, MM, 2022)
"In this study, we aimed to evaluate serum irisin and apelin levels in patients with subclinical hypothyroidism (SCH) when they were subclinical hypothyroid and become euthyroid after levothyroxine therapy and association of these adipokines with markers of atherosclerosis such as serum homocysteine levels and carotid intima-media thickness (IMT)."3.91Serum irisin and apelin levels and markers of atherosclerosis in patients with subclinical hypothyroidism. ( Colak, A; Demirpence, M; Ekinci, F; Günaslan, A; Turkon, H; Yasar, E; Yasar, HY; Yurdakul, L; Zeytinli, M, 2019)
"Free thyroxine levels in middle-aged and elderly subjects were positively associated with atherosclerosis throughout the whole disease spectrum, independent of cardiovascular risk factors."3.85Thyroid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study. ( Bano, A; Chaker, L; Franco, OH; Ikram, MA; Kavousi, M; Mattace-Raso, FUS; Peeters, RP; van der Lugt, A, 2017)
"Concentrations of thyroid stimulating hormone (TSH), free thyroxine (FT4), triiodothyronine (T3) and thyroid peroxidase antibody (TPOAb) were quantified in 12 785 black and white participants of the ongoing community-based prospective Atherosclerosis Risk in Communities study."3.85Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study. ( Coresh, J; Daya, N; Grams, ME; Köttgen, A; Schultheiss, UT; Selvin, E; Seufert, J; Steffes, M, 2017)
" Since thyroid hormones may mediate the association between ARG derivatives and atherosclerosis, this study investigated whether asymmetric and symmetric dimethylarginines (ADMA and SDMA, respectively) as well as homoarginine (hARG) are associated with parameters of thyroid function in the general population."3.83L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population. ( Atzler, D; Bahls, M; Böger, RH; Dörr, M; Felix, SB; Friedrich, N; Ittermann, T; Schwedhelm, E; Völzke, H, 2016)
"To investigate the effect of levothyroxine (L-T4) treatment on early markers of atherosclerotic disease in children with mild idiopathic subclinical hypothyroidism (SH)."3.83Effects of L-thyroxine treatment on early markers of atherosclerotic disease in children with subclinical hypothyroidism. ( Alfano, S; Capalbo, D; Cerbone, M; Cittadini, A; De Luca, F; Mattace Raso, G; Oliviero, U; Salerno, M; Wasniewska, M, 2016)
" We aimed to explore the changes in atherosclerotic risk factors and insulin sensitivity before and after levothyroxine replacement therapy in women with primary hypothyroidism and compare with that of healthy controls."3.80Effects of levothyroxine treatment on insulin sensitivity, endothelial function and risk factors of atherosclerosis in hypothyroid women. ( Akalın, NS; Akpınar, IN; Deyneli, O; Gözü, H; Meriçliler, OS; Yıldız, ME, 2014)
"Serum total bilirubin, thyrotropin and free thyroxine (free T4), transaminases, insulin sensitivity (homeostasis model assessment), and lipids were measured in 74 T2DM and 82 nondiabetic subjects with thyrotropin and free T4 levels within the euthyroid range."3.79Low-normal free thyroxine confers decreased serum bilirubin in type 2 diabetes mellitus. ( Bakker, SJ; Deetman, PE; Dullaart, RP; Kwakernaak, AJ, 2013)
" We hypothesized that L-thyroxine replacement therapy might be able to reverse the process associated with increase in CIMT in patients with primary hypothyroidism."3.75Effects of L-thyroxine replacement therapy on carotid intima-media thickness in patients with primary hypothyroidism. ( Aral, Y; Cakal, B; Cakal, E; Demirbas, B; Ozkaya, M; Serter, R; Turgut, AT, 2009)
"Instability of atherosclerotic plaque in hypothyroidism could cause excessive activity of the elements of innate immunity, which are characterized by the significant presence of macrophages in atherosclerotic plaques, increased nuclear factor kappa B (NFkB) expression, and elevated levels of tumor necrosis factor α (TNF-α) and matrix metalloproteinase (MMP) 9, with reduced interstitial collagen; all of them together creates inflammation milieu, resulting in plaque rupture."2.82Hypothyroidism and Risk of Cardiovascular Disease. ( Gluvic, ZM; Isenovic, ER; Obradovic, MM; Rizzo, M; Sudar-Milovanovic, EM; Zafirovic, SS, 2022)
"Subclinical hypothyroidism is also associated with the risk of progression to overt hypothyroidism and with the risk of neuropsychiatric effects."2.44[Subclinical hypothyroidism]. ( Krysiak, R; Marek, B; Okopień, B, 2008)
"Sub-clinical hypothyroidism is defined by elevated serum thyroid-stimulating hormone level in the face of normal free thyroid hormone values."2.43[Cardiovascular remodelling in patients with sub-clinical hypothyroidism]. ( Antonelli, A; Franzoni, F; Galetta, F; Rossi, M; Santoro, G, 2006)
"Hypothyroidism is a common endocrine disorder and requires lifelong treatment."1.91Impact of Levothyroxine on Lipid Profile in Patients with Hypothyroidism. ( Ara, S; Islam, MN; Moni, SY; Rahman, FB; Sultana, Z; Zubery, MH, 2023)
"Hypothyroidism was subsequently diagnosed."1.62Acute Hepatopathy in a Dog Secondary to Hypothyroidism-Induced Atherosclerotic Infarction and Necrosis. ( Bolton, TA, 2021)
"Primary hypothyroidism can affect lipid metabolism, cardiovascular (CV) function, and overall patients' quality of life (QoL)."1.51Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females. ( Gluvic, ZM; Isenovic, ER; Jevremovic, DP; Obradovic, MM; Radenkovic, SP; Samardzic, VS; Sudar-Milovanovic, EM, 2019)
"Clinical hypothyroidism was prevalent (>20% of individuals studied) and was associated with cerebrovascular disease but not Alzheimer's disease-type neuropathology."1.48Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. ( Brenowitz, WD; Han, F; Kukull, WA; Nelson, PT, 2018)
"These findings suggest that elevated cholesterol concentrations in the blood, especially against the background of suppressed thyroid function, can directly induce considerable damage to cardiomyocytes, intramural vessels, and erythrocytes without the development of myocardial ischemia and in the absence of atherosclerotic plaques."1.39Structural changes in the myocardium and serum lipid spectrum in experimental hypercholesterolemia and hypothyroidism. ( Klinnikova, MG; Lushnikova, EL; Molodykh, OP; Nepomnyashchikh, LM; Nepomnyashchikh, RD; Pichigin, VI; Polyakov, LP; Poteryaeva, ON; Russkikh, GS, 2013)
"Seventy subjects with Type 2 diabetes mellitus (T2DM), 37 subjects with impaired fasting glucose (IFG) and 31 subjects with normal fasting glucose (NFG) (revised NCEP-ATPIII criteria) participated in a cross-sectional study."1.39Low normal free T4 confers decreased high-density lipoprotein antioxidative functionality in the context of hyperglycaemia. ( Annema, W; de Boer, JF; Dullaart, RP; Kwakernaak, AJ; Tietge, UJ; Triolo, M, 2013)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-199014 (28.00)18.7374
1990's0 (0.00)18.2507
2000's7 (14.00)29.6817
2010's25 (50.00)24.3611
2020's4 (8.00)2.80

Authors

AuthorsStudies
Łukawska-Tatarczuk, MM1
Zieliński, J1
Franek, E1
Czupryniak, L1
Mrozikiewicz-Rakowska, B1
Gluvic, ZM2
Zafirovic, SS1
Obradovic, MM2
Sudar-Milovanovic, EM2
Rizzo, M1
Isenovic, ER2
Rahman, FB1
Zubery, MH1
Moni, SY1
Ara, S1
Sultana, Z1
Islam, MN1
Samardzic, VS1
Jevremovic, DP1
Radenkovic, SP1
Bolton, TA1
Bano, A1
Chaker, L1
Mattace-Raso, FUS1
van der Lugt, A1
Ikram, MA1
Franco, OH1
Peeters, RP1
Kavousi, M1
Brenowitz, WD1
Han, F1
Kukull, WA1
Nelson, PT1
Anderson, JL1
Zhao, JV1
Schooling, CM1
Ning, Y1
Zhang, M1
DU, YH1
Zhang, HN1
Li, LY1
Qin, YW1
Wen, WW1
Zhao, QM1
Blum, MR1
Gencer, B1
Adam, L1
Feller, M1
Collet, TH1
da Costa, BR1
Moutzouri, E1
Dopheide, J1
Depairon, M1
Sykiotis, GP1
Kearney, P1
Gussekloo, J1
Westendorp, R1
Stott, DJ1
Bauer, DC1
Rodondi, N1
Dietlein, M1
Drzezga, A1
Yasar, HY1
Demirpence, M1
Colak, A1
Yurdakul, L1
Zeytinli, M1
Turkon, H1
Ekinci, F1
Günaslan, A1
Yasar, E1
Deetman, PE1
Kwakernaak, AJ2
Bakker, SJ1
Dullaart, RP3
Nepomnyashchikh, LM1
Lushnikova, EL1
Polyakov, LP1
Molodykh, OP1
Klinnikova, MG1
Russkikh, GS1
Poteryaeva, ON1
Nepomnyashchikh, RD1
Pichigin, VI1
Delitala, AP1
Orrù, M1
Filigheddu, F1
Pilia, MG1
Delitala, G1
Ganau, A1
Saba, PS1
Decandia, F1
Scuteri, A1
Marongiu, M1
Lakatta, EG1
Strait, J1
Cucca, F1
Deyneli, O1
Akpınar, IN1
Meriçliler, OS1
Gözü, H1
Yıldız, ME1
Akalın, NS1
Zhang, Y2
Wang, Q1
Li, Q1
Lu, P1
Zha, K1
Zuo, C1
Wang, A1
Zhang, B1
Wang, B1
Wang, Y1
Zhao, J1
Gao, L1
Xu, C1
Ittermann, T1
Bahls, M1
Atzler, D1
Friedrich, N1
Schwedhelm, E1
Böger, RH1
Felix, SB1
Völzke, H1
Dörr, M1
Cerbone, M3
Capalbo, D3
Wasniewska, M1
Alfano, S1
Mattace Raso, G1
Oliviero, U2
Cittadini, A2
De Luca, F2
Salerno, M3
Schultheiss, UT1
Daya, N1
Grams, ME1
Seufert, J1
Steffes, M1
Coresh, J1
Selvin, E1
Köttgen, A1
Krysiak, R1
Marek, B1
Okopień, B1
Cakal, E1
Turgut, AT1
Demirbas, B1
Ozkaya, M1
Cakal, B1
Serter, R1
Aral, Y1
Parmar, HS1
Kar, A1
Bosso, G1
Valvano, A1
Apuzzi, V1
Calabrese, F1
Lettiero, T1
Kowalska, I1
Borawski, J1
Nikołajuk, A1
Budlewski, T1
Otziomek, E1
Górska, M1
Strączkowski, M1
Alibaz Oner, F1
Yurdakul, S1
Oner, E1
Kubat Uzum, A1
Erguney, M1
Mugii, S1
Hanada, H1
Okubo, M1
Masuda, D1
Takeoka, K1
Hidaka, Y1
Ohama, T1
Matsuyama, A1
Nakagawa-Toyama, Y1
Nishida, M1
Ishigami, M1
Komuro, I1
Yamashita, S1
Kim, ES1
Shin, JA1
Shin, JY1
Lim, DJ1
Moon, SD1
Son, HY1
Han, JH1
Triolo, M1
de Boer, JF1
Annema, W1
Tietge, UJ1
CUTHBERTSON, WF1
ELCOATE, PV1
IRELAND, DM1
MILLS, DC1
SHEARLEY, P1
DAVIS, OF1
BECK, C1
BERGAL, M1
SLOAN, N1
LEVINE, AJ1
DUFAULT, C2
TREMBLAY, G2
NOWACZYNSKI, W2
GENEST, J2
FELT, V1
ROEHLING, S1
VOHNOUT, S1
HLADOVEC, J1
ROMERO, RL1
RODRIGUEZ, R1
FERRARA, F1
MALJAR, L1
CACCIATORE, J1
VELARDE, HV1
LOEPER, J2
KRITCHEVSKY, D1
SOULAIRAC, A1
BEROUTI, R1
CAHN, J1
AYMARD, N1
FISHER, ER1
SIMONIN, R1
FRUCTUS, X1
GEROLAMI AUDRIC, D1
BAINBOROUGH, AR1
McMILLAN, GC1
Liou, YM1
Chang, LY1
Liaw, JM1
Jiang, MJ1
Rossi, M1
Galetta, F1
Franzoni, F1
Antonelli, A1
Santoro, G1
de Vries, R1
Roozendaal, C1
Kobold, AC1
Sluiter, WJ1
Teixeira, PF1
Reuters, VS1
Ferreira, MM1
Almeida, CP1
Reis, FA1
Melo, BA1
Buescu, A1
Costa, AJ1
Vaisman, M1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis: Review on the Pathway of Insulin Resistance, Lipid, Inflammation, and Endothelial Dysfunction to Pulse Wave Velocity and Carotid Intima-Media Thickness[NCT05118542]Phase 336 participants (Actual)Interventional2019-01-01Completed
Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism.[NCT02832934]Phase 4184 participants (Actual)Interventional2016-06-30Completed
Effect of Levothyroxine on Serum Adiponectin, Insulin Resistance and Cardiovascular Risk in Patients With Hypothyroidism[NCT02467244]120 participants (Actual)Observational2017-02-01Completed
Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism[NCT02090907]Phase 2/Phase 350 participants (Actual)Interventional2013-05-31Completed
Effects of Dapagliflozin on Hyperlipidemia, Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients (DAPHNIS Study)[NCT02577159]Phase 450 participants (Anticipated)Interventional2015-07-01Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for thyroxine and Atherogenesis

ArticleYear
Hypothyroidism and Risk of Cardiovascular Disease.
    Current pharmaceutical design, 2022, Volume: 28, Issue:25

    Topics: Aged; Atherosclerosis; Cardiovascular Diseases; Female; Humans; Hypothyroidism; Plaque, Atherosclero

2022
Subclinical hypothyroidism in childhood - current knowledge and open issues.
    Nature reviews. Endocrinology, 2016, Volume: 12, Issue:12

    Topics: Anticonvulsants; Antiviral Agents; Asymptomatic Diseases; Atherosclerosis; Bone Diseases, Metabolic;

2016
[Subclinical hypothyroidism].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2008, Volume: 61, Issue:4-6

    Topics: Atherosclerosis; Cardiovascular Diseases; Comorbidity; Disease Progression; Humans; Hypothyroidism;

2008
[Cardiovascular remodelling in patients with sub-clinical hypothyroidism].
    Minerva cardioangiologica, 2006, Volume: 54, Issue:6

    Topics: Atherosclerosis; Carotid Arteries; Humans; Hypothyroidism; Risk Factors; Thyroxine; Ultrasonography;

2006

Trials

5 trials available for thyroxine and Atherogenesis

ArticleYear
Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial.
    The Journal of clinical endocrinology and metabolism, 2018, 08-01, Volume: 103, Issue:8

    Topics: Aged; Aged, 80 and over; Asymptomatic Diseases; Atherosclerosis; Double-Blind Method; Female; Hormon

2018
Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects.
    BioMed research international, 2015, Volume: 2015

    Topics: Adult; Aged; Atherosclerosis; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Hyper

2015
Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy.
    Endocrine, 2011, Volume: 40, Issue:1

    Topics: Adiponectin; Adult; Aged; Atherosclerosis; Biomarkers; Blood Glucose; Case-Control Studies; Choleste

2011
Evaluation of the effect of L-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism.
    Endocrine, 2011, Volume: 40, Issue:2

    Topics: Adult; Atherosclerosis; Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Female; Hormone

2011
Treatment of subclinical hypothyroidism reduces atherogenic lipid levels in a placebo-controlled double-blind clinical trial.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2008, Volume: 40, Issue:1

    Topics: Atherosclerosis; Double-Blind Method; Female; Humans; Hypothyroidism; Lipid Metabolism; Male; Menopa

2008

Other Studies

41 other studies available for thyroxine and Atherogenesis

ArticleYear
[Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?]
    Endokrynologia Polska, 2022, Volume: 73, Issue:2

    Topics: Atherosclerosis; Autoimmunity; Carotid Intima-Media Thickness; Diabetes Mellitus, Type 1; Female; Ha

2022
Impact of Levothyroxine on Lipid Profile in Patients with Hypothyroidism.
    Mymensingh medical journal : MMJ, 2023, Volume: 32, Issue:3

    Topics: Atherosclerosis; Bangladesh; Cholesterol, LDL; Cross-Sectional Studies; Female; Humans; Hypothyroidi

2023
Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females.
    Medical hypotheses, 2019, Volume: 131

    Topics: Adult; Atherosclerosis; Biomarkers; Blood Pressure; Body Mass Index; C-Reactive Protein; Female; Gly

2019
Acute Hepatopathy in a Dog Secondary to Hypothyroidism-Induced Atherosclerotic Infarction and Necrosis.
    Journal of the American Animal Hospital Association, 2021, Jan-01, Volume: 57, Issue:1

    Topics: Animals; Atherosclerosis; Dog Diseases; Dogs; Hepatic Infarction; Hypothyroidism; Liver Diseases; Ma

2021
Thyroid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study.
    Circulation research, 2017, Dec-08, Volume: 121, Issue:12

    Topics: Aged; Atherosclerosis; Female; Humans; Male; Middle Aged; Thyroid Gland; Thyroxine

2017
Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults.
    Neurobiology of aging, 2018, Volume: 62

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Atherosclerosis; Cerebrovascular Disorders; Drug Combina

2018
Circulating Thyroxine: A Major New Risk Marker for Atherosclerosis?
    Circulation research, 2017, 12-08, Volume: 121, Issue:12

    Topics: Atherosclerosis; Atrial Fibrillation; Humans; Thyroxine

2017
Letter by Zhao and Schooling Regarding Article, "Thyroid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study".
    Circulation research, 2018, 02-02, Volume: 122, Issue:3

    Topics: Atherosclerosis; Humans; Thyroxine

2018
[Effects of thyroid hormone on macrophage dysfunction induced by oxidized low-density lipoprotein].
    Sheng li xue bao : [Acta physiologica Sinica], 2018, Apr-25, Volume: 70, Issue:2

    Topics: Animals; Atherosclerosis; Chemokine CCL2; Foam Cells; Focal Adhesion Kinase 1; Interleukin-1beta; Li

2018
    Nuklearmedizin. Nuclear medicine, 2018, Volume: 57, Issue:5

    Topics: Atherosclerosis; Cognition Disorders; Drug Utilization; Heart Diseases; Humans; Hypothyroidism; Rena

2018
Serum irisin and apelin levels and markers of atherosclerosis in patients with subclinical hypothyroidism.
    Archives of endocrinology and metabolism, 2019, Volume: 63, Issue:1

    Topics: Adult; Aged; Apelin; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; Case-Control Studi

2019
Low-normal free thyroxine confers decreased serum bilirubin in type 2 diabetes mellitus.
    Thyroid : official journal of the American Thyroid Association, 2013, Volume: 23, Issue:11

    Topics: Aged; Antioxidants; Aspartate Aminotransferases; Atherosclerosis; Bilirubin; Cholesterol; Diabetes M

2013
Structural changes in the myocardium and serum lipid spectrum in experimental hypercholesterolemia and hypothyroidism.
    Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:5

    Topics: Animals; Atherosclerosis; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease;

2013
Serum free thyroxine levels are positively associated with arterial stiffness in the SardiNIA study.
    Clinical endocrinology, 2015, Volume: 82, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aorta; Atherosclerosis; Body Mass Index; Cardiovascular

2015
Effects of levothyroxine treatment on insulin sensitivity, endothelial function and risk factors of atherosclerosis in hypothyroid women.
    Annales d'endocrinologie, 2014, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Atherosclerosis; Endothelium, Vascular; Female; Glucose Clamp Technique; Humans;

2014
LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation.
    Lipids in health and disease, 2015, Aug-25, Volume: 14

    Topics: Asymptomatic Diseases; Atherosclerosis; Body Mass Index; Carotid Intima-Media Thickness; Female; Hum

2015
L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population.
    Thyroid : official journal of the American Thyroid Association, 2016, Volume: 26, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Atherosclerosis; Cross-Sectional Studies; Female; Germany;

2016
Effects of L-thyroxine treatment on early markers of atherosclerotic disease in children with subclinical hypothyroidism.
    European journal of endocrinology, 2016, Volume: 175, Issue:1

    Topics: Adolescent; Atherosclerosis; Biomarkers; Blood Pressure; Carotid Intima-Media Thickness; Case-Contro

2016
Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2017, Nov-01, Volume: 32, Issue:11

    Topics: Atherosclerosis; Biomarkers; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hy

2017
Effects of L-thyroxine replacement therapy on carotid intima-media thickness in patients with primary hypothyroidism.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2009, Volume: 117, Issue:6

    Topics: Adult; Atherosclerosis; Carotid Arteries; Cholesterol, HDL; Cholesterol, LDL; Female; Hormone Replac

2009
Possible amelioration of atherogenic diet induced dyslipidemia, hypothyroidism and hyperglycemia by the peel extracts of Mangifera indica, Cucumis melo and Citrullus vulgaris fruits in rats.
    BioFactors (Oxford, England), 2008, Volume: 33, Issue:1

    Topics: Animals; Ascorbic Acid; Atherosclerosis; Blood Glucose; Citrullus; Creatine Kinase, MB Form; Cucumis

2008
Effects of long-term L-thyroxine treatment on endothelial function and arterial distensibility in young adults with congenital hypothyroidism.
    European journal of endocrinology, 2010, Volume: 162, Issue:2

    Topics: Adolescent; Atherosclerosis; Brachial Artery; Case-Control Studies; Congenital Hypothyroidism; Endot

2010
Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease.
    Journal of atherosclerosis and thrombosis, 2012, Volume: 19, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Apolipoprotein B-48; Atherosclerosis; Case-Control Studi

2012
Association between low serum free thyroxine concentrations and coronary artery calcification in healthy euthyroid subjects.
    Thyroid : official journal of the American Thyroid Association, 2012, Volume: 22, Issue:9

    Topics: Adult; Aged; Atherosclerosis; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans; Male

2012
Low normal free T4 confers decreased high-density lipoprotein antioxidative functionality in the context of hyperglycaemia.
    Clinical endocrinology, 2013, Volume: 79, Issue:3

    Topics: Aged; Antioxidants; Atherosclerosis; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Diabet

2013
ADMINISTRATION of hormones and related substances in atherosclerosis.
    Hormoner, 1958, Volume: 11, Issue:6

    Topics: Arteriosclerosis; Atherosclerosis; Cholesterol; Estrogens; Hormones; Lipoproteins; Thyroxine

1958
Effect of compounds related to thyroxine on serum and liver cholesterol and on atherosclerosis and heart weights in rats and mice.
    The Journal of endocrinology, 1960, Volume: 21

    Topics: Animals; Arteriosclerosis; Atherosclerosis; Cholesterol; Heart; Liver; Mice; Rats; Thyroxine

1960
Some observations on the relationships between atherosclerosis, hyperlipemia, and D-thyroxine.
    American heart journal, 1962, Volume: 64

    Topics: Arteriosclerosis; Atherosclerosis; Cholesterol; Dextrothyroxine; Estrogens; Humans; Hyperlipidemias;

1962
Influence of dextro-thyroxine and androsterone on blood clotting factors and serum cholesterol in patients with atherosclerosis.
    Canadian Medical Association journal, 1961, Nov-04, Volume: 85

    Topics: Androgens; Androsterone; Arteriosclerosis; Atherosclerosis; Blood Coagulation; Blood Coagulation Fac

1961
[Action of dextro-thyroxine and androsterone on blood cholesterol and coagulation factors in atherosclerosis].
    L'union medicale du Canada, 1961, Volume: 90

    Topics: Androgens; Androsterone; Arteriosclerosis; Atherosclerosis; Blood Coagulation; Blood Coagulation Fac

1961
[EFFECT OF DIFFERENT PHASES OF EXPERIMENTAL ATHEROSCLEROSIS, CORTISONE AND THYROXIN ON THE DEPOSITION OF 4-C14LABELLED CHOLESTEROL IN RABBIT AORTA].
    Ceskoslovenska gastroenterologie a vyziva, 1963, Volume: 17

    Topics: Animals; Aorta; Arteriosclerosis; Atherosclerosis; Carbon Isotopes; Cholesterol; Cortisone; Lagomorp

1963
[INFLUENCE OF SODIUM DEXTROTHYROXIN IN THE HORMONAL IMBALANCE OF ATHEROSCLEROSIS].
    Prensa medica argentina, 1963, Feb-22, Volume: 50

    Topics: Arteriosclerosis; Atherosclerosis; Blood Proteins; Cholesterol; Dextrothyroxine; Lipid Metabolism; L

1963
[THE PROBLEM OF TREATMENT OF ATHEROSCLEROSIS WITH THYROXIN OR RELATED COMPOUNDS].
    Le Progres medical, 1963, Oct-24, Volume: 91

    Topics: Arteriosclerosis; Atherosclerosis; Humans; Thyroid Hormones; Thyroxine

1963
[THE ACTION OF THYROMIMETIC COMPOUNDS ON EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS AND ON CHOLESTEROL METABOLISM IN RATS].
    Revue de l'atherosclerose, 1963, Volume: 5

    Topics: Arteriosclerosis; Atherosclerosis; Cholesterol; Dinitrophenols; Lipid Metabolism; Lipoproteins; Phar

1963
[ON CERTAIN BIOCHEMICAL ASPECTS OF THE DYSLIPEMIC PROCESS IN ITS RELATIONS TO ATHEROSCLEROSIS. TREATMENT TRIALS WITH D-THYROXIN].
    La Presse medicale, 1964, Jun-27, Volume: 72

    Topics: Arteriosclerosis; Atherosclerosis; Cholesterol; Humans; Lipoproteins; Thyroxine

1964
THYROIDAL INFLUENCE ON EXPERIMENTAL CHOLESTEROL ATHEROSCLEROSIS.
    The American journal of pathology, 1964, Volume: 45

    Topics: Adrenal Glands; Animals; Arteriosclerosis; Atherosclerosis; Blood Proteins; Body Weight; Cholesterol

1964
[ACTION OF DEXTRO-THYROXIN IN TREATMENT OF DYSLIPEMIAS OF ATHEROSCLEROSIS].
    Gazette medicale de France, 1964, Dec-25, Volume: 71

    Topics: Arteriosclerosis; Atherosclerosis; Dextrothyroxine; Humans; Lipidoses; Lipids; Thyroxine

1964
Atherosclerosis and dextrorotatory thyroxine.
    The South Dakota journal of medicine and pharmacy, 1961, Volume: 14

    Topics: Arteriosclerosis; Atherosclerosis; Thyroxine

1961
Effect of thyroxin and 2,4-dinitrophenol on the retrogression of experimental atherosclerosis.
    A.M.A. archives of pathology, 1952, Volume: 54, Issue:2

    Topics: 2,4-Dinitrophenol; Arteriosclerosis; Atherosclerosis; Dinitrophenols; Nitrophenols; Thyroxine

1952
Osteopontin gene expression in the aorta and the heart of propylthiouracil-induced hypothyroid mice.
    Journal of biomedical science, 2005, Volume: 12, Issue:6

    Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Blood Pressure; Blotting, Western; Body Weight;

2005
Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects.
    Clinical endocrinology, 2007, Volume: 67, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Atherosclerosis; Autoantibodies; C-Reactive Protein; Carotid Arterie

2007