thyroxine and Asymptomatic Conditions studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

Excerpt	Relevance	Reference
"Previous trials on the effect of levothyroxine on depressive symptom scores in patients with subclinical hypothyroidism were limited by small sample sizes (N = 57 to 94) and potential biases."	9.41	Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism: An Ancillary Study of a Randomized Clinical Trial. ( Aujesky, D; Bauer, DC; Collet, TH; Del Giovane, C; Du Puy, RS; Feller, M; Gussekloo, J; Kearney, P; Klöppel, S; Mooijaart, SP; Moutzouri, E; Peeters, RP; Poortvliet, RKE; Quinn, TJ; Rodondi, N; Westendorp, R; Wildisen, L, 2021)
"Both thyroid dysfunction and levothyroxine (LT4) therapy have been associated with bone loss, but studies on the effect of LT4 for subclinical hypothyroidism (SHypo) on bone yielded conflicting results."	9.34	Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. ( Aeberli, D; Bauer, DC; Blum, MR; Collet, TH; Del Giovane, C; Feller, M; Gonzalez Rodriguez, E; Gussekloo, J; Hans, D; Kearney, PM; Löwe, AL; Mooijaart, S; Rodondi, N; Stott, DJ; Stuber, M; van Heemst, D; van Vliet, NA; Westendorp, RGJ, 2020)
"This is a follow-up study of the Tehran Thyroid and Pregnancy Study, a randomized trial in which subclinical hypothyroid pregnant women were assigned to an intervention group (treated with levothyroxine) or a control group (received no treatment)."	9.30	Evaluation of the impact of levothyroxine treatment on the psychomotor developmental status of three-year-old children born to mothers with mild thyroid impairment; Tehran Thyroid and pregnancy study: study protocol for a randomized clinical trial. ( Azizi, F; Bidhendi Yarandi, R; Nazarpour, S; Ramezani Tehrani, F; Sajedi, F, 2019)
"Subclinical hypothyroidism is a common condition in patients with heart failure and is defined as elevated serum thyroid hormone (TSH) with normal circulating free thyroxine (FT4)."	9.30	Efficacy and safety of levothyroxine (L-T4) replacement on the exercise capability in chronic systolic heart failure patients with subclinical hypothyroidism: Study protocol for a multi-center, open label, randomized, parallel group trial (ThyroHeart-CHF) ( An, SM; Chen, J; Liu, YP; Tang, YD; Tian, J; Wang, JJ; Wang, SY; Wang, WY; Yang, M; Zhang, K; Zhang, X; Zhao, Y; Zheng, JL, 2019)
" We have designed protocols for a prospective observational study to assess the association of thyroid function at the time of acute myocardial infarction (AMI) with cardiovascular outcomes, and a double-blinded randomised placebo-controlled trial of levothyroxine to evaluate its effect on LV function and vascular health."	9.20	Thyroxine in acute myocardial infarction (ThyrAMI) - levothyroxine in subclinical hypothyroidism post-acute myocardial infarction: study protocol for a randomised controlled trial. ( Ingoe, L; Jabbar, A; Pearce, S; Razvi, S; Zaman, A, 2015)
"The question of whether children with subclinical hypothyroidism (SH) should be treated or not is controversial due to the lack of studies on outcomes of SH children treated with L-thyroxine (L-T(4)) versus those receiving no therapy."	9.16	Comparative evaluation of therapy with L-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism. ( Aversa, T; Corrias, A; De Luca, F; De Martino, L; Lombardo, F; Mussa, A; Salerno, M; Valenzise, M; Wasniewska, M, 2012)
"The goal of this study was to review relevant randomized controlled trials in order to determine the clinical efficacy of levothyroxine in the treatment of overt or subclinical hypothyroidism."	9.05	Levothyroxine in the treatment of overt or subclinical hypothyroidism: a systematic review and meta-analysis. ( Chen, Y; Tai, HY, 2020)
"To determine in women with subclinical hypothyroidism diagnosed in pregnancy whether levothyroxine treatment compared with control, impacts important obstetrical or childhood outcomes (specifically IQ) in randomised controlled trials."	8.98	Impact of levothyroxine therapy on obstetric, neonatal and childhood outcomes in women with subclinical hypothyroidism diagnosed in pregnancy: a systematic review and meta-analysis of randomised controlled trials. ( Benham, JL; Donovan, LE; Nerenberg, KA; Yamamoto, JM, 2018)
"Our study aimed to describe levothyroxine prescription patterns and trends over time among pregnant women with subclinical hypothyroidism (SCH) in the United Kingdom."	8.02	Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population-based assessment. ( Filion, KB; Grandi, SM; Platt, RW; Reynier, P; Yu, OHY; Yu, YH, 2021)
"The major purpose of this study was to investigate the effect of resveratrol (RES) on the spatial learning and memory ability in subclinical hypothyroidism (SCH) rat model and the potential mechanism."	7.81	Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. ( Chen, FH; Chu, CH; Ge, JF; Li, N; Qin, G; Qiu, GL; Wang, CY; Xu, YY; Zhang, Y, 2015)
" This study measured levels of adhesion molecules before and after levothyroxine therapy in patients with subclinical hypothyroidism (SHO)."	7.80	Subclinical hypothyroidism: Comparison of adhesion molecule levels before and after levothyroxine therapy. ( Bilgir, F; Bilgir, O; Calan, M; Calan, O; Isikyakar, T, 2014)
" The present study aimed to investigate whether maternal subclinical hypothyroidism impairs spatial learning in the offspring, as well as the efficacy and optimal time of levothyroxine (L-T(4)) treatment in pregnancy."	7.78	Early levothyroxine treatment on maternal subclinical hypothyroidism improves spatial learning of offspring in rats. ( Fan, C; Gao, Y; Shan, Z; Teng, W; Wang, S; Zhang, H, 2012)
"Previous trials on the effect of levothyroxine on depressive symptom scores in patients with subclinical hypothyroidism were limited by small sample sizes (N = 57 to 94) and potential biases."	5.41	Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism: An Ancillary Study of a Randomized Clinical Trial. ( Aujesky, D; Bauer, DC; Collet, TH; Del Giovane, C; Du Puy, RS; Feller, M; Gussekloo, J; Kearney, P; Klöppel, S; Mooijaart, SP; Moutzouri, E; Peeters, RP; Poortvliet, RKE; Quinn, TJ; Rodondi, N; Westendorp, R; Wildisen, L, 2021)
"Both thyroid dysfunction and levothyroxine (LT4) therapy have been associated with bone loss, but studies on the effect of LT4 for subclinical hypothyroidism (SHypo) on bone yielded conflicting results."	5.34	Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. ( Aeberli, D; Bauer, DC; Blum, MR; Collet, TH; Del Giovane, C; Feller, M; Gonzalez Rodriguez, E; Gussekloo, J; Hans, D; Kearney, PM; Löwe, AL; Mooijaart, S; Rodondi, N; Stott, DJ; Stuber, M; van Heemst, D; van Vliet, NA; Westendorp, RGJ, 2020)
"Levothyroxine in older adults with mild subclinical hypothyroidism provides no change in physical or mental fatigability."	5.34	Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial. ( Aujesky, D; Bauer, DC; Blum, MR; Collet, TH; Del Giovane, C; Feller, M; Glynn, NW; Gussekloo, J; Kearney, PM; McCarthy, VJC; Mooijaart, SP; Moutzouri, E; Rodondi, N; Stott, DJ; Stuber, MJ; Westendorp, R, 2020)
"This is a follow-up study of the Tehran Thyroid and Pregnancy Study, a randomized trial in which subclinical hypothyroid pregnant women were assigned to an intervention group (treated with levothyroxine) or a control group (received no treatment)."	5.30	Evaluation of the impact of levothyroxine treatment on the psychomotor developmental status of three-year-old children born to mothers with mild thyroid impairment; Tehran Thyroid and pregnancy study: study protocol for a randomized clinical trial. ( Azizi, F; Bidhendi Yarandi, R; Nazarpour, S; Ramezani Tehrani, F; Sajedi, F, 2019)
"Subclinical hypothyroidism is a common condition in patients with heart failure and is defined as elevated serum thyroid hormone (TSH) with normal circulating free thyroxine (FT4)."	5.30	Efficacy and safety of levothyroxine (L-T4) replacement on the exercise capability in chronic systolic heart failure patients with subclinical hypothyroidism: Study protocol for a multi-center, open label, randomized, parallel group trial (ThyroHeart-CHF) ( An, SM; Chen, J; Liu, YP; Tang, YD; Tian, J; Wang, JJ; Wang, SY; Wang, WY; Yang, M; Zhang, K; Zhang, X; Zhao, Y; Zheng, JL, 2019)
"Subclinical hypothyroidism (SHypo) has been associated with atherosclerosis, but no conclusive clinical trials assessing the levothyroxine impact on carotid atherosclerosis exist."	5.27	Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial. ( Adam, L; Bauer, DC; Blum, MR; Collet, TH; da Costa, BR; Depairon, M; Dopheide, J; Feller, M; Gencer, B; Gussekloo, J; Kearney, P; Moutzouri, E; Rodondi, N; Stott, DJ; Sykiotis, GP; Westendorp, R, 2018)
"Previous studies examining associations between subclinical hypothyroidism (SCH) with in vitro fertilization (IVF) outcome indicate some benefits of levothyroxine (LT4) treatment."	5.24	Outcome of in vitro fertilization in women with subclinical hypothyroidism. ( Cai, Y; Guan, J; Guo, R; Ma, Y; Niu, B; Su, H; Zhong, L, 2017)
" We have designed protocols for a prospective observational study to assess the association of thyroid function at the time of acute myocardial infarction (AMI) with cardiovascular outcomes, and a double-blinded randomised placebo-controlled trial of levothyroxine to evaluate its effect on LV function and vascular health."	5.20	Thyroxine in acute myocardial infarction (ThyrAMI) - levothyroxine in subclinical hypothyroidism post-acute myocardial infarction: study protocol for a randomised controlled trial. ( Ingoe, L; Jabbar, A; Pearce, S; Razvi, S; Zaman, A, 2015)
"Echocardiography and serum thyroid hormones were assessed in overt primary (n=20) and central (n=10) hypothyroidism, subclinical primary hypothyroidism (n=10), hypothalamic-pituitary disease with normal free thyroxine (FT(4); n=25), and controls (n=28)."	5.16	Diagnosis of subclinical central hypothyroidism in patients with hypothalamic-pituitary disease by Doppler echocardiography. ( Abucham, J; Doin, FC; Martins, MR; Moisés, VA; Rosa-Borges, M, 2012)
"The question of whether children with subclinical hypothyroidism (SH) should be treated or not is controversial due to the lack of studies on outcomes of SH children treated with L-thyroxine (L-T(4)) versus those receiving no therapy."	5.16	Comparative evaluation of therapy with L-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism. ( Aversa, T; Corrias, A; De Luca, F; De Martino, L; Lombardo, F; Mussa, A; Salerno, M; Valenzise, M; Wasniewska, M, 2012)
"The goal of this study was to review relevant randomized controlled trials in order to determine the clinical efficacy of levothyroxine in the treatment of overt or subclinical hypothyroidism."	5.05	Levothyroxine in the treatment of overt or subclinical hypothyroidism: a systematic review and meta-analysis. ( Chen, Y; Tai, HY, 2020)
" Pregnancy places additional demands on the thyroid axis and around 5% of women who have their thyroid function checked during gestation will have borderline low thyroid function (subclinical hypothyroidism or isolated hypothyroxinemia) identified."	5.05	Indications for treatment of subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy. ( Lazarus, JH; Muller, I; Nana, M; Taylor, PN; Velasco, I, 2020)
"To determine in women with subclinical hypothyroidism diagnosed in pregnancy whether levothyroxine treatment compared with control, impacts important obstetrical or childhood outcomes (specifically IQ) in randomised controlled trials."	4.98	Impact of levothyroxine therapy on obstetric, neonatal and childhood outcomes in women with subclinical hypothyroidism diagnosed in pregnancy: a systematic review and meta-analysis of randomised controlled trials. ( Benham, JL; Donovan, LE; Nerenberg, KA; Yamamoto, JM, 2018)
"Subclinical hypothyroidism (also known as compensated hypothyroidism or mild hypothyroidism) is a condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4)."	4.95	Subclinical hypothyroidism: Should we treat? ( Redford, C; Vaidya, B, 2017)
"Subclinical hypothyroidism, which is defined as elevated thyroid-stimulating hormone (TSH) levels with free thyroxine concentrations within the reference range, is a common disorder that increases with age and affects up to 18% of the elderly, with a higher prevalence in women compared to men."	4.90	Subclinical hypothyroidism: summary of evidence in 2014. ( Baumgartner, C; Blum, MR; Rodondi, N, 2014)
"To investigate the auto-oxidized oxysterols, 7-ketocholesterol (7-KC) and cholestane-3β,5α,6β-triol (chol-triol), in patients with subclinical hypothyroidism, as well as to evaluate the impact of restoring euthyroidism on oxysterol concentrations."	4.02	Oxysterol species generated by auto-oxidation in subclinical hypothyroidism. ( Fırlatan, B; Gürlek, A; Lay, İ; Oğuz, SH; Samadi, A; Savaş, M; Ünlütürk, U; Yüce, D, 2021)
"Our study aimed to describe levothyroxine prescription patterns and trends over time among pregnant women with subclinical hypothyroidism (SCH) in the United Kingdom."	4.02	Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population-based assessment. ( Filion, KB; Grandi, SM; Platt, RW; Reynier, P; Yu, OHY; Yu, YH, 2021)
"Subclinical hyperthyroidism is defined by a subnormal serum thyroidstimulating hormone (TSH) level with normal free thyroxine (FT4) and free triiodothyronine (FT3) levels."	3.96	Role of Subclinical Iatrogenic Hyperthyroidism in the Setting of Heart Disease and Arrhythmic Burden. ( De Luca, G; Di Stolfo, G; Maggio, A; Massaro, R; Mastroianno, S; Pacilli, M; Potenza, DR; Russo, A, 2020)
"At median 10, 18, and 26 weeks of gestation, we observed significant inverse associations between free thyroxine (FT4) and birth weight z scores, with the strongest association detected at median 10 weeks, at which time a 10% increase in FT4 was associated with a 0."	3.88	Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth. ( Cantonwine, DE; Ferguson, KK; Johns, LE; McElrath, TF; Meeker, JD; Mukherjee, B, 2018)
"CV = cardiovascular DMN = diabetic nephropathy eGFR = estimated glomerular filtration rate fT4 = free thyroxine HbA1c = glycosylated hemoglobin HR = hazard ratio hs-CRP = high-sensitivity C-reactive protein LDL-C = low-density lipoprotein cholesterol SCH = subclinical hypothyroidism T2DM = type 2 diabetes THRT = thyroid hormone replacement therapy TSH = thyroid-stimulating hormone."	3.88	THYROID HORMONE REPLACEMENT REDUCES THE RISK OF CARDIOVASCULAR DISEASES IN DIABETIC NEPHROPATHY PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM. ( Cha, MU; Han, SH; Jhee, JH; Kang, SW; Kee, YK; Kim, H; Kim, S; Lee, M; Park, JT; Park, S; Seo, C; Yoo, TH; Yun, HR, 2018)
" It is unknown, however, whether the relationships between maternal thyrotropin (TSH) and free thyroxine (fT4) levels in early pregnancy and fetal growth outcomes are modified by fetal sex."	3.85	Early Maternal Thyroid Function During Gestation Is Associated With Fetal Growth, Particularly in Male Newborns. ( Hrudey, EJ; Twickler, MB; Vrijkotte, TG, 2017)
"The major purpose of this study was to investigate the effect of resveratrol (RES) on the spatial learning and memory ability in subclinical hypothyroidism (SCH) rat model and the potential mechanism."	3.81	Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. ( Chen, FH; Chu, CH; Ge, JF; Li, N; Qin, G; Qiu, GL; Wang, CY; Xu, YY; Zhang, Y, 2015)
" This study measured levels of adhesion molecules before and after levothyroxine therapy in patients with subclinical hypothyroidism (SHO)."	3.80	Subclinical hypothyroidism: Comparison of adhesion molecule levels before and after levothyroxine therapy. ( Bilgir, F; Bilgir, O; Calan, M; Calan, O; Isikyakar, T, 2014)
" They were classified into 5 groups: 1) subclinical-hypothyroid (SHY), 2) overt-hypothyroid (OHY), 3) subclinical-hyperthyroid (SHE), 4) overt-hyperthyroid (OHE), 5) patients under thyroxine therapy (EU), and normal controls."	3.80	Dyslipidemia and serum mineral profiles in patients with thyroid disorders. ( Abdel-Gayoum, AA, 2014)
"5 mIU/L with a normal free thyroxine or free thyroxine index); from 2008 onward, levothyroxine treatment prepregnancy to maintain TSH ≤2."	3.79	Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss. ( Bernardi, LA; Cohen, RN; Stephenson, MD, 2013)
" Women with subclinical hypothyroidism (thyroid-stimulating hormone (TSH) values at or above the 98th percentile with a normal free thyroxine (fT4)) or isolated maternal hypothyroxinaemia (fT4 level at or below the second percentile with a normal-range TSH) were compared with biochemically euthyroid controls."	3.79	Subclinical hypothyroidism as a risk factor for placental abruption: evidence from a low-risk primigravid population. ( Breathnach, FM; Cooley, SM; Donnelly, J; Geary, M; Malone, FD, 2013)
" The present study aimed to investigate whether maternal subclinical hypothyroidism impairs spatial learning in the offspring, as well as the efficacy and optimal time of levothyroxine (L-T(4)) treatment in pregnancy."	3.78	Early levothyroxine treatment on maternal subclinical hypothyroidism improves spatial learning of offspring in rats. ( Fan, C; Gao, Y; Shan, Z; Teng, W; Wang, S; Zhang, H, 2012)
"The aim of this study was to estimate the prevalence of depressive symptoms in patients affected by subclinical hypothyroidism by means of Hamilton Rating Scale for Depression (HAM-D) and Montgomery-Asberg Depression Rating Scale (MADRS); to assess which depressive symptoms are prevalent in our population, with references to the factorialization of HAM-D by Cleary and Guy (1977); to verify whether levothyroxine replacement therapy alone can induce total remission of depressive symptoms."	3.76	Prevalence of depression in patients affected by subclinical hypothyroidism. ( Demartini, B; Gambini, O; Masu, A; Pontiroli, AE; Scarone, S, 2010)
"Two studies found an increase in cancer mortality among patients with SCH compared to euthyroid individuals; in contrast one study found no association between subclinical hypothyroidism and cancer mortality among aging men."	2.66	Subclinical hypothyroidism and the risk of cancer incidence and cancer mortality: a systematic review. ( Azoulay, L; Boivin, JF; Filion, KB; Gómez-Izquierdo, J; Pollak, M; Yu, OHY, 2020)
"Hypothyroidism is one of the most common endocrinopathies in reproductive-age and pregnant women."	2.50	Controversies in the management of hypothyroidism during pregnancy. ( Caughey, AB; Patton, PE; Samuels, MH; Trinidad, R, 2014)
"Hypothyroidism is the most common pregnancy-related thyroid disorder, affecting 3-5% of all pregnant women."	2.49	Hypothyroidism in pregnancy. ( Cooper, DS; Patil-Sisodia, K; Shan, Z; Teng, W, 2013)
"In differentiated thyroid cancer (DTC), the standard treatment includes total thyroidectomy and lifetime levothyroxine (LT4) replacement."	1.62	Effects of Chronic Suppression or Oversuppression of Thyroid-Stimulating Hormone on Psychological Symptoms and Sleep Quality in Patients with Differentiated Thyroid Cancer. ( Altuntaş, SÇ; Hocaoğlu, Ç, 2021)
"Subclinical hypothyroidism affects 4."	1.56	Subclinical hypothyroidism: To treat or not to treat? ( Allen, S; Simon, C; Weidman-Evans, E, 2020)
"Overt hypothyroidism is frequently found in patients with type 2 diabetes mellitus (T2DM), but it remains unknown the relationship between subclinical hypothyroidism (SCH) and T2DM."	1.43	Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus. ( Cho, JH; Kim, HJ; Lee, HW; Lee, IK; Lee, JH; Moon, JS; Park, IR; Won, KC; Yoon, JS, 2016)
"However, its clinical importance in autoimmune thyroiditis remains unknown."	1.43	Low levels of circulating platelet factor 4 (PF4, CXCL4) in subclinically hypothyroid autoimmune thyroiditis. ( Ademoğlu, E; Alioğlu, B; Aral, Y; Bekdemir, H; Candan, Z; Çarlıoğlu, A; Culha, C; Görar, S; Sağlam, B; Üçler, R, 2016)
"Perinatal outcomes of women with treated overt hypothyroidism were similar to women with euthyroidism."	1.42	An analysis of population-based prenatal screening for overt hypothyroidism. ( Bryant, SN; Casey, BM; Cunningham, FG; McIntire, DD; Nelson, DB, 2015)
"Overt hypothyroidism was defined as low FT4 (normal values: 0."	1.40	Subclinical non-autoimmune hypothyroidism in children with steroid resistant nephrotic syndrome. ( Batra, V; Dubey, NK; Goyal, P; Kapoor, K; Saha, A; Suresh, CP; Upadhayay, AD, 2014)
"The incidence of gestational diabetes was compared among these three groups."	1.38	Relationship of subclinical thyroid disease to the incidence of gestational diabetes. ( Casey, BM; Cunningham, FG; McIntire, DD; Tudela, CM, 2012)
"Hypothyroidism is a common endocrine disorder that mainly affects women and the elderly."	1.38	Hypothyroidism. ( Grossmann, M; MacIsaac, RJ; So, M, 2012)
"Although overt thyrotoxicosis is associated with reduced insulin sensitivity (IS), the effects of subclinical thyrotoxicosis (SCTox) (i."	1.37	The association of insulin resistance with subclinical thyrotoxicosis. ( Alberto, M; Brenta, G; Niepomniszcze, H; Pusiol, E; Rezzonico, J; Rezzonico, M, 2011)

Research

Studies (87)

Authors

Clinical Trials (9)

Trial Overview

Trial Outcomes

Completion Rate

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	67 (77.01)	24.3611
2020's	20 (22.99)	2.80

Authors	Studies
Altuntaş, SÇ	1
Hocaoğlu, Ç	1
Szeliga, K	1
Antosz, A	1
Skrzynska, K	1
Kalina-Faska, B	1
Januszek-Trzciakowska, A	1
Gawlik, A	1
Gonzalez Rodriguez, E	1
Stuber, M	1
Del Giovane, C	3
Feller, M	5
Collet, TH	5
Löwe, AL	1
Blum, MR	4
van Vliet, NA	1
van Heemst, D	1
Kearney, PM	2
Gussekloo, J	5
Mooijaart, S	1
Westendorp, RGJ	2
Stott, DJ	4
Aeberli, D	1
Bauer, DC	5
Hans, D	1
Rodondi, N	6
Mastroianno, S	1
Di Stolfo, G	1
Maggio, A	1
Pacilli, M	1
Potenza, DR	1
Massaro, R	1
De Luca, G	1
Russo, A	1
Ohba, K	1
Okada, E	1
Goto, Y	1
Suzuki, S	1
Machii, M	1
Nonaka, D	1
Matsushita, A	1
Sasaki, S	1
Suda, T	1
Oki, Y	1
Takase, H	1
Ni, J	1
Zhang, L	1
Zhang, X	3
Chen, Y	1
Tai, HY	1
Simon, C	1
Weidman-Evans, E	1
Allen, S	1
Sigal, GA	1
Tavoni, TM	1
Silva, BMO	1
Khalil-Filho, R	1
Brandão, LG	1
Baracat, EC	1
Maranhão, RC	1
Gómez-Izquierdo, J	1
Filion, KB	2
Boivin, JF	1
Azoulay, L	1
Pollak, M	1
Yu, OHY	2
Stuber, MJ	1
Moutzouri, E	3
Mooijaart, SP	2
McCarthy, VJC	1
Aujesky, D	3
Westendorp, R	3
Glynn, NW	1
Groenwold, RHH	1
Dekkers, OM	1
Taylor, PN	1
Muller, I	1
Nana, M	1
Velasco, I	1
Lazarus, JH	1
Burgos, N	1
Toloza, FJK	1
Singh Ospina, NM	2
Brito, JP	2
Salloum, RG	1
Hassett, LC	1
Maraka, S	3
Wildisen, L	1
Du Puy, RS	1
Poortvliet, RKE	1
Kearney, P	2
Quinn, TJ	1
Klöppel, S	1
Peeters, RP	2
Ünlütürk, U	1
Savaş, M	1
Oğuz, SH	1
Samadi, A	1
Fırlatan, B	1
Yüce, D	1
Lay, İ	1
Gürlek, A	1
Carlé, A	1
Karmisholt, JS	1
Knudsen, N	1
Perrild, H	1
Thuesen, BH	1
Ovesen, L	1
Rasmussen, LB	1
Pedersen, IB	1
Fukushita, M	1
Watanabe, N	1
Yoshimura Noh, J	1
Yoshihara, A	1
Matsumoto, M	1
Suzuki, N	1
Yoshimura, R	1
Sugino, K	1
Ito, K	1
Ross, JS	1
El Kawkgi, OM	1
Deng, Y	1
Shah, ND	1
Lipska, KJ	1
Yu, YH	1
Reynier, P	1
Platt, RW	1
Grandi, SM	1
Vrijkotte, TG	1
Hrudey, EJ	1
Twickler, MB	1
Redford, C	1
Vaidya, B	1
Sharma, N	1
Dutta, D	1
Sharma, LK	1
Cai, Y	1
Zhong, L	1
Guan, J	1
Guo, R	1
Niu, B	1
Ma, Y	1
Su, H	1
Plowden, TC	1
Schisterman, EF	1
Sjaarda, LA	1
Perkins, NJ	1
Silver, R	1
Radin, R	1
Kim, K	1
Galai, N	1
DeCherney, AH	1
Mumford, SL	1
He, L	1
Shen, C	1
Zhang, Y	4
Chen, Z	1
Ding, H	1
Liu, J	1
Zha, B	1
Baumgartner, C	2
da Costa, BR	2
Floriani, C	1
Cappola, AR	3
Heckbert, SR	1
Ceresini, G	2
den Elzen, WPJ	1
Luben, R	1
Völzke, H	1
Dörr, M	1
Walsh, JP	1
Bremner, A	1
Iacoviello, M	1
Macfarlane, P	1
Heeringa, J	1
Khaw, KT	1
Magnani, JW	1
Ates, I	2
Arikan, MF	1
Altay, M	2
Yilmaz, FM	3
Yilmaz, N	2
Berker, D	3
Guler, S	3
Johns, LE	1
Ferguson, KK	1
Cantonwine, DE	1
Mukherjee, B	1
Meeker, JD	1
McElrath, TF	1
Seo, C	1
Kim, S	1
Lee, M	1
Cha, MU	1
Kim, H	1
Park, S	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial[NCT01660126]	Phase 4	737 participants (Actual)	Interventional	2014-05-31	Completed
Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment[NCT02491008]	Phase 4	145 participants (Actual)	Interventional	2014-01-31	Completed
Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism[NCT02500342]	Phase 4	276 participants (Actual)	Interventional	2014-01-31	Completed
Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism: a Pilot Randomized, Double-blinded, Placebo-controlled Study[NCT04288115]	Phase 4	52 participants (Actual)	Interventional	2021-03-24	Completed
Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) - Subanalysis on Subclinical Hypothyroidism and Depression[NCT01853579]	Phase 4	426 participants (Actual)	Interventional	2013-03-31	Completed
The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363]		1,228 participants (Actual)	Interventional	2007-06-30	Completed
Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism.[NCT02832934]	Phase 4	184 participants (Actual)	Interventional	2016-06-30	Completed
Efficacy and Safety of Levothyroxine (L-T4) Replacement on Exercise Capability in Chronic Systolic Heart Failure Patients With Subclinical Hypothyroidism: A 24-week, Multi-center, Open Label, Randomized, Parallel Group Trial[NCT03096613]	Phase 4	124 participants (Anticipated)	Interventional	2017-04-18	Recruiting
Maternal TSH Level and TPOAb Status in Early Pregnancy and Their Relationship to the Risk of Gestational Diabetes Mellitus[NCT02555332]		7,729 participants (Actual)	Observational	2012-12-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Percentage of randomized participants who completed the trial. (NCT04288115)
Timeframe: 6 months

Participants' Willingness to Enter the Trial

Intervention	Participants (Count of Participants)
Randomized Participants	44

Percent of eligible participants approached who consented to participate during the recruitment phase. (NCT04288115)
Timeframe: The time from first consent signed to last consent signed. March 2021 to April 2022.

Recruitment Rate

Intervention	Participants (Count of Participants)
Percentage of Eligible Patients Willing to Participate.	52

The number of enrolled (consented) participants divided by the length of the recruitment period. (NCT04288115)
Timeframe: The time from first consent signed to last consent signed. March 2021 to April 2022. 13 months.

Euro Quality of Life 5-Dimension Self-Report Questionnaire (EQ-5D) Score at Week 6 and Month 6

Intervention	participants per month (Number)
Recruitment Rate	4

The EuroQoL [EQ] Group 5-Dimension Self-Report Questionnaire (EQ-5D) scores include the EQ-5D descriptive index, on a scale from -0.59 to 1.00. Higher scores indicate better quality of life. The EQ-5D scores include the score on the EQ visual-analogue scale (EQ-5D VAS), on a scale from 0 to 100. Higher scores indicate better quality of life. (NCT04288115)
Timeframe: 6 weeks and 6 months

Lipid Levels

Intervention	score on a scale (Mean)
	EQ-5D Descriptive Score 6 weeks	EQ-5D Descriptive Score 6 months	EQ-5D VAS 6 weeks	EQ-5D VAS 6 months
"Levothyroxine Group (Sham Discontinuation)"	0.759	0.742	78.0	68.4
"Placebo Group (Real Discontinuation)"	0.786	0.750	77.2	79.9

Differences in mean 6-month lipid levels after adjusting for gender and baseline lipid level. (NCT04288115)
Timeframe: 6 months

Thyroid-specific Quality of Life Patient-Reported Outcome (ThyPRO) - Hypothyroid Symptoms Score

Intervention	mg/dL (Mean)
	Total cholesterol 6 months	LDL 6 months	HDL 6 months	Triglycerides 6 months
"Levothyroxine Group (Sham Discontinuation)"	145.3	76.5	42.7	137.5
"Placebo Group (Real Discontinuation)"	177.4	100.2	51.5	139.7

The Hypothyroid Symptoms score from the Thyroid-Related Quality of Life Patient-Reported Outcome (ThyPRO) questionnaire is assessed on a scale from 0 to 100, with higher scores indicating more symptoms. (NCT04288115)
Timeframe: Baseline, 6 weeks and 6 months

Thyroid-specific Quality of Life Patient-Reported Outcome (ThyPRO) - Tiredness Score

Intervention	score on a scale (Mean)
	Baseline	6 weeks	6 months
"Levothyroxine Group (Sham Discontinuation)"	21.1	22.0	22.9
"Placebo Group (Real Discontinuation)"	27.1	25.3	28.3

The Tiredness score from the Thyroid-Related Quality of Life Patient-Reported Outcome (ThyPRO) questionnaire is assessed on a scale from 0 to 100, with higher scores indicating more tiredness. (NCT04288115)
Timeframe: Baseline, 6 weeks and 6 months

Abruption

Intervention	score on a scale (Mean)
	Baseline	6 weeks	6 months
"Levothyroxine Group (Sham Discontinuation)"	31.1	33.0	32.8
"Placebo Group (Real Discontinuation)"	33.2	31.1	27.6

Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery

Clinically Recognized Pregnancy

Early Pregnancy Loss (EPL)

Ectopic Pregnancy

Fetal Pregnancy Loss

hCG Recognized Pregnancy

Live Birth

Intervention	participants (Number)
Aspirin	7
Placebo	5

Intervention	pregnancy (Number)
Aspirin	374
Placebo	346

Intervention	pregnancy (Number)
Aspirin	28
Placebo	27

Intervention	pregnancy (Number)
Aspirin	3
Placebo	3

Intervention	pregnancy (Number)
Aspirin	4
Placebo	6

Intervention	pregnancy (Number)
Aspirin	394
Placebo	363

Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery

Molar Pregnancy

Preeclampsia

Pregnancy Losses Occurring Less Than 10 Weeks

Intervention	livebirths (Number)
Aspirin	309
Placebo	286

Intervention	pregnancy (Number)
Aspirin	0
Placebo	0

Intervention	participants (Number)
Aspirin	32
Placebo	30

Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks

Article	Year
Levothyroxine in the treatment of overt or subclinical hypothyroidism: a systematic review and meta-analysis. Endocrine journal, 2020, Jul-28, Volume: 67, Issue:7 Topics: Adult; Aged; Asymptomatic Diseases; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Mal	2020
Subclinical hypothyroidism and the risk of cancer incidence and cancer mortality: a systematic review. BMC endocrine disorders, 2020, Jun-09, Volume: 20, Issue:1 Topics: Asymptomatic Diseases; Humans; Hypothyroidism; Incidence; Neoplasms; Odds Ratio; Thyrotropin; Thyrox	2020
Indications for treatment of subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy. Best practice & research. Clinical endocrinology & metabolism, 2020, Volume: 34, Issue:4 Topics: Asymptomatic Diseases; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Complications; Prenatal	2020
Clinical Outcomes After Discontinuation of Thyroid Hormone Replacement: A Systematic Review and Meta-Analysis. Thyroid : official journal of the American Thyroid Association, 2021, Volume: 31, Issue:5 Topics: Asymptomatic Diseases; Deprescriptions; Hormone Replacement Therapy; Humans; Hypothyroidism; Thyroxi	2021
Subclinical hypothyroidism: Should we treat? Post reproductive health, 2017, Volume: 23, Issue:2 Topics: Asymptomatic Diseases; Cardiovascular Diseases; Humans; Hypothyroidism; Mental Disorders; Metabolic	2017
Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation. Circulation, 2017, Nov-28, Volume: 136, Issue:22 Topics: Adult; Aged; Aged, 80 and over; Asymptomatic Diseases; Atrial Fibrillation; Biomarkers; Chi-Square D	2017
Impact of levothyroxine therapy on obstetric, neonatal and childhood outcomes in women with subclinical hypothyroidism diagnosed in pregnancy: a systematic review and meta-analysis of randomised controlled trials. BMJ open, 2018, 09-08, Volume: 8, Issue:9 Topics: Asymptomatic Diseases; Child; Child Development; Female; Humans; Hypothyroidism; Pregnancy; Pregnanc	2018
[Subclinical Hypothyroidism on the Elderly]. Acta medica portuguesa, 2018, Dec-28, Volume: 31, Issue:12 Topics: Age Factors; Aged; Aged, 80 and over; Asymptomatic Diseases; Humans; Hypothyroidism; Reference Value	2018
Hypothyroidism in pregnancy. The lancet. Diabetes & endocrinology, 2013, Volume: 1, Issue:3 Topics: Asymptomatic Diseases; Child; Child Development; Female; Humans; Hypothyroidism; Pregnancy; Prevalen	2013
Controversies in the management of hypothyroidism during pregnancy. Obstetrical & gynecological survey, 2014, Volume: 69, Issue:6 Topics: Asymptomatic Diseases; Autoantibodies; Female; Humans; Hypothyroidism; Immunoglobulins, Thyroid-Stim	2014
Subclinical hypothyroidism: summary of evidence in 2014. Swiss medical weekly, 2014, Volume: 144 Topics: Asymptomatic Diseases; Cardiovascular Diseases; Female; Humans; Hypothyroidism; Male; Mental Disorde	2014
Low-normal thyroid function and the pathogenesis of common cardio-metabolic disorders. European journal of clinical investigation, 2015, Volume: 45, Issue:5 Topics: Asymptomatic Diseases; Cardiovascular Diseases; Cholesterol, LDL; Humans; Hypothyroidism; Insulin Re	2015
Subclinical hypothyroidism in childhood - current knowledge and open issues. Nature reviews. Endocrinology, 2016, Volume: 12, Issue:12 Topics: Anticonvulsants; Antiviral Agents; Asymptomatic Diseases; Atherosclerosis; Bone Diseases, Metabolic;	2016

Article	Year
Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. The Journal of clinical endocrinology and metabolism, 2020, 01-01, Volume: 105, Issue:1 Topics: Age of Onset; Aged; Aged, 80 and over; Asymptomatic Diseases; Bone and Bones; Bone Density; Bone Rem	2020
Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. The Journal of clinical endocrinology and metabolism, 2020, 01-01, Volume: 105, Issue:1 Topics: Age of Onset; Aged; Aged, 80 and over; Asymptomatic Diseases; Bone and Bones; Bone Density; Bone Rem	2020
Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. The Journal of clinical endocrinology and metabolism, 2020, 01-01, Volume: 105, Issue:1 Topics: Age of Onset; Aged; Aged, 80 and over; Asymptomatic Diseases; Bone and Bones; Bone Density; Bone Rem	2020
Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. The Journal of clinical endocrinology and metabolism, 2020, 01-01, Volume: 105, Issue:1 Topics: Age of Onset; Aged; Aged, 80 and over; Asymptomatic Diseases; Bone and Bones; Bone Density; Bone Rem	2020
Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial. The journals of gerontology. Series A, Biological sciences and medical sciences, 2020, 09-16, Volume: 75, Issue:9 Topics: Aged; Aged, 80 and over; Asymptomatic Diseases; Fatigue; Female; Humans; Hypothyroidism; Male; Thyro	2020
Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism: An Ancillary Study of a Randomized Clinical Trial. JAMA network open, 2021, 02-01, Volume: 4, Issue:2 Topics: Aged; Aged, 80 and over; Asymptomatic Diseases; Depression; Double-Blind Method; Female; Humans; Hyp	2021
Outcome of in vitro fertilization in women with subclinical hypothyroidism. Reproductive biology and endocrinology : RB&E, 2017, May-25, Volume: 15, Issue:1 Topics: Adult; Asymptomatic Diseases; Female; Fertilization in Vitro; Hormone Replacement Therapy; Humans; H	2017
Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial. The Journal of clinical endocrinology and metabolism, 2018, 08-01, Volume: 103, Issue:8 Topics: Aged; Aged, 80 and over; Asymptomatic Diseases; Atherosclerosis; Double-Blind Method; Female; Hormon	2018
Evaluation of the impact of levothyroxine treatment on the psychomotor developmental status of three-year-old children born to mothers with mild thyroid impairment; Tehran Thyroid and pregnancy study: study protocol for a randomized clinical trial. Trials, 2019, Jan-28, Volume: 20, Issue:1 Topics: Age Factors; Asymptomatic Diseases; Child Behavior; Child Development; Child, Preschool; Female; Hum	2019
Efficacy and safety of levothyroxine (L-T4) replacement on the exercise capability in chronic systolic heart failure patients with subclinical hypothyroidism: Study protocol for a multi-center, open label, randomized, parallel group trial (ThyroHeart-CHF) Trials, 2019, Feb-19, Volume: 20, Issue:1 Topics: Asymptomatic Diseases; China; Chronic Disease; Exercise Tolerance; Heart Failure, Systolic; Hormone	2019
Levothyroxine improves abnormal cardiac bioenergetics in subclinical hypothyroidism: a cardiac magnetic resonance spectroscopic study. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:4 Topics: Adult; Asymptomatic Diseases; Energy Metabolism; Female; Heart; Humans; Hypothyroidism; Magnetic Res	2015
Thyroxine in acute myocardial infarction (ThyrAMI) - levothyroxine in subclinical hypothyroidism post-acute myocardial infarction: study protocol for a randomised controlled trial. Trials, 2015, Mar-25, Volume: 16 Topics: Asymptomatic Diseases; Biomarkers; Clinical Protocols; Double-Blind Method; England; Female; Humans;	2015
Primary and Secondary Hemostasis in Patients With Subclinical Hypothyroidism: Effect of Levothyroxine Treatment. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:7 Topics: Adult; Asymptomatic Diseases; Female; Fibrinolysis; Follow-Up Studies; Hemostasis; Humans; Hypothyro	2015
Changes in the before and after thyroxine treatment levels of adipose tissue, leptin, and resistin in subclinical hypothyroid patients. Wiener klinische Wochenschrift, 2016, Volume: 128, Issue:15-16 Topics: Adult; Asymptomatic Diseases; Biomarkers; Female; Hormone Replacement Therapy; Humans; Hypothyroidis	2016
Diagnosis of subclinical central hypothyroidism in patients with hypothalamic-pituitary disease by Doppler echocardiography. European journal of endocrinology, 2012, Volume: 166, Issue:4 Topics: Adult; Asymptomatic Diseases; Cross-Sectional Studies; Diagnostic Techniques, Endocrine; Echocardiog	2012
Comparative evaluation of therapy with L-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism. Hormone research in paediatrics, 2012, Volume: 77, Issue:6 Topics: Adolescent; Asymptomatic Diseases; Child; Child, Preschool; Female; Hormone Replacement Therapy; Hum	2012

Article	Year
Effects of Chronic Suppression or Oversuppression of Thyroid-Stimulating Hormone on Psychological Symptoms and Sleep Quality in Patients with Differentiated Thyroid Cancer. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2021, Volume: 53, Issue:10 Topics: Adenocarcinoma, Follicular; Adolescent; Adult; Aged; Asymptomatic Diseases; Case-Control Studies; Ch	2021
Subclinical Hypothyroidism as the Most Common Thyroid Dysfunction Status in Children With Down's Syndrome. Frontiers in endocrinology, 2021, Volume: 12 Topics: Adolescent; Asymptomatic Diseases; Autoantibodies; Body Mass Index; Child; Child, Preschool; Down Sy	2021
Role of Subclinical Iatrogenic Hyperthyroidism in the Setting of Heart Disease and Arrhythmic Burden. Endocrine, metabolic & immune disorders drug targets, 2020, Volume: 20, Issue:6 Topics: Aged; Arrhythmias, Cardiac; Asymptomatic Diseases; Cardiovascular System; Female; Heart Diseases; Ho	2020
Influence of thyroid dysfunction on brain natriuretic peptide level in health examination participants. Endocrine journal, 2020, Apr-28, Volume: 67, Issue:4 Topics: Adult; Aged; Asymptomatic Diseases; Blood Pressure; Body Mass Index; Female; Glomerular Filtration R	2020
Marked elevation of creatine phosphokinase alone caused by sintilimab - beware of hypothyroid myopathy. European journal of cancer (Oxford, England : 1990), 2020, Volume: 128 Topics: Adenocarcinoma of Lung; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Prot	2020
Subclinical hypothyroidism: To treat or not to treat? JAAPA : official journal of the American Academy of Physician Assistants, 2020, Volume: 33, Issue:5 Topics: Aged; Asymptomatic Diseases; Autoantigens; Biomarkers; Cardiovascular Diseases; Diagnosis, Different	2020
Subclinical Hyperthyroidism: Status of the Cholesterol Transfers to HDL and Other Parameters Related to Lipoprotein Metabolism in Patients Submitted to Thyroidectomy for Thyroid Cancer. Frontiers in endocrinology, 2020, Volume: 11 Topics: Adenocarcinoma; Adult; Asymptomatic Diseases; Brazil; Case-Control Studies; Cholesterol; Cholesterol	2020
Missing data: the impact of what is not there. European journal of endocrinology, 2020, Volume: 183, Issue:4 Topics: Age of Onset; Aged; Aged, 80 and over; Asymptomatic Diseases; Bias; Hormone Replacement Therapy; Hum	2020
Oxysterol species generated by auto-oxidation in subclinical hypothyroidism. Clinical biochemistry, 2021, Volume: 93 Topics: Adult; Asymptomatic Diseases; Cholestanols; Chromatography, Liquid; Female; Humans; Hypothyroidism;	2021
Does Subclinical Hypothyroidism Add Any Symptoms? Evidence from a Danish Population-Based Study. The American journal of medicine, 2021, Volume: 134, Issue:9 Topics: Adult; Age Factors; Alcohol Drinking; Asymptomatic Diseases; Body Mass Index; Case-Control Studies;	2021
A case of macro-TSH consisting of IgA-bound TSH. Endocrine journal, 2021, Oct-28, Volume: 68, Issue:10 Topics: Aged; Asymptomatic Diseases; Chromatography, Gel; False Positive Reactions; Humans; Hypothyroidism;	2021
Levothyroxine Use in the United States, 2008-2018. JAMA internal medicine, 2021, 10-01, Volume: 181, Issue:10 Topics: Adult; Asymptomatic Diseases; Cross-Sectional Studies; Drug Utilization; Female; Humans; Hypothyroid	2021
Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population-based assessment. Pharmacology research & perspectives, 2021, Volume: 9, Issue:5 Topics: Adult; Asymptomatic Diseases; Diabetes Mellitus; Female; Humans; Hypothyroidism; Infertility, Female	2021
Early Maternal Thyroid Function During Gestation Is Associated With Fetal Growth, Particularly in Male Newborns. The Journal of clinical endocrinology and metabolism, 2017, 03-01, Volume: 102, Issue:3 Topics: Adult; Asymptomatic Diseases; Autoantibodies; Birth Weight; Cohort Studies; Female; Fetal Macrosomia	2017
Hyperprolactinemia in Children with Subclinical Hypothyroidism. Journal of clinical research in pediatric endocrinology, 2017, Dec-15, Volume: 9, Issue:4 Topics: Adolescent; Asymptomatic Diseases; Child; Child, Preschool; Female; Humans; Hyperprolactinemia; Hypo	2017
Thyroid-stimulating hormone, anti-thyroid antibodies, and pregnancy outcomes. American journal of obstetrics and gynecology, 2017, Volume: 217, Issue:6 Topics: Adult; Asymptomatic Diseases; Autoantibodies; Cohort Studies; Diabetes, Gestational; Female; Humans;	2017
Evaluation of serum ferritin and thyroid function in the second trimester of pregnancy. Endocrine journal, 2018, Jan-30, Volume: 65, Issue:1 Topics: Adult; Anemia, Iron-Deficiency; Asymptomatic Diseases; China; Female; Ferritins; Humans; Hypothyroid	2018
The effect of oxidative stress on the progression of Hashimoto's thyroiditis. Archives of physiology and biochemistry, 2018, Volume: 124, Issue:4 Topics: Adult; Algorithms; Asymptomatic Diseases; Biomarkers; Disease Progression; Female; Follow-Up Studies	2018
Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth. The Journal of clinical endocrinology and metabolism, 2018, 04-01, Volume: 103, Issue:4 Topics: Adolescent; Adult; Asymptomatic Diseases; Birth Weight; Case-Control Studies; Female; Fetal Developm	2018
THYROID HORMONE REPLACEMENT REDUCES THE RISK OF CARDIOVASCULAR DISEASES IN DIABETIC NEPHROPATHY PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2018, Volume: 24, Issue:3 Topics: Aged; Asymptomatic Diseases; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathi	2018
Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study. Nutrients, 2018, May-30, Volume: 10, Issue:6 Topics: Adult; Aged; Asymptomatic Diseases; Brazil; Cohort Studies; Cross-Sectional Studies; Deficiency Dise	2018
Waist Circumference and Subclinical Thyroid Dysfunction in a Large Cohort of Chinese Men and Women. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2018, Volume: 24, Issue:8 Topics: Adult; Aged; Asymptomatic Diseases; China; Cohort Studies; Cross-Sectional Studies; Female; Healthy	2018
Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes. Circulation. Heart failure, 2018, Volume: 11, Issue:12 Topics: Adult; Aged; Asymptomatic Diseases; Biomarkers; Comorbidity; Female; Heart Failure; Humans; Hypothyr	2018
Hyperthyroidism influences renal function. Endocrine, 2019, Volume: 65, Issue:1 Topics: Adult; Aged; Asymptomatic Diseases; Creatinine; Female; Glomerular Filtration Rate; Humans; Hyperthy	2019
[Electrocardiographic and hemodynamic profile of patients with psychotic disorder]. Annales de cardiologie et d'angeiologie, 2019, Volume: 68, Issue:3 Topics: Adult; Aged; Asymptomatic Diseases; Blood Pressure Determination; Chi-Square Distribution; Cross-Sec	2019
Subclinical non-autoimmune hypothyroidism in children with steroid resistant nephrotic syndrome. Clinical and experimental nephrology, 2014, Volume: 18, Issue:1 Topics: Adolescent; Asymptomatic Diseases; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cross-	2014
Higher free thyroxine levels are associated with all-cause mortality in euthyroid older men: the Health In Men Study. European journal of endocrinology, 2013, Volume: 169, Issue:4 Topics: Aged; Aged, 80 and over; Aging; Asymptomatic Diseases; Comorbidity; Humans; Hyperthyroidism; Hypothy	2013
Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss. Fertility and sterility, 2013, Volume: 100, Issue:5 Topics: Abortion, Habitual; Abortion, Spontaneous; Academic Medical Centers; Adult; Asymptomatic Diseases; B	2013
Subclinical hypothyroidism as a risk factor for placental abruption: evidence from a low-risk primigravid population. The Australian & New Zealand journal of obstetrics & gynaecology, 2013, Volume: 53, Issue:6 Topics: Abruptio Placentae; Adult; Antibodies; Asymptomatic Diseases; Case-Control Studies; Female; Gravidit	2013
Subclinical hypothyroidism: Comparison of adhesion molecule levels before and after levothyroxine therapy. The Journal of international medical research, 2014, Volume: 42, Issue:3 Topics: Adult; Asymptomatic Diseases; Case-Control Studies; Drug Administration Schedule; E-Selectin; Female	2014
Thyroid hormones and coronary artery calcification in euthyroid men and women. Arteriosclerosis, thrombosis, and vascular biology, 2014, Volume: 34, Issue:9 Topics: Adult; Aged; Asymptomatic Diseases; Cohort Studies; Comorbidity; Coronary Artery Disease; Cross-Sect	2014
Thyroxine treatment may be useful for subclinical hypothyroidism in patients with female infertility. Endocrine journal, 2015, Volume: 62, Issue:1 Topics: Abortion, Spontaneous; Adult; Asymptomatic Diseases; Autoantibodies; Embryo Implantation, Delayed; F	2015
Dyslipidemia and serum mineral profiles in patients with thyroid disorders. Saudi medical journal, 2014, Volume: 35, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asymptomatic Diseases; Blood Glucose; Child; Cholesterol	2014
Thyroid function abnormalities associated with ponatinib therapy in patients with chronic myeloid leukemia. Thyroid : official journal of the American Thyroid Association, 2015, Volume: 25, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; Asymptomatic Diseases; Female; Humans; Hypothyroidism; Imidazole	2015
Low levels of circulating platelet factor 4 (PF4, CXCL4) in subclinically hypothyroid autoimmune thyroiditis. Journal of endocrinological investigation, 2016, Volume: 39, Issue:2 Topics: Adolescent; Adult; Aged; Asymptomatic Diseases; Autoantibodies; Autoantigens; Biomarkers; Down-Regul	2016
An analysis of population-based prenatal screening for overt hypothyroidism. American journal of obstetrics and gynecology, 2015, Volume: 213, Issue:4 Topics: Adolescent; Adult; Asymptomatic Diseases; Cohort Studies; Female; Humans; Hypertension, Pregnancy-In	2015
Influence of thyroid dysfunction on serum levels of angiopoietin-like protein 6. Metabolism: clinical and experimental, 2015, Volume: 64, Issue:10 Topics: Adult; Angiopoietin-Like Protein 6; Angiopoietin-like Proteins; Angiopoietins; Asymptomatic Diseases	2015
Subclinical hypothyroidism: a 'laboratory-induced' condition? European journal of endocrinology, 2015, Volume: 173, Issue:4 Topics: Asymptomatic Diseases; Decision Making; Hormone Replacement Therapy; Humans; Hypothyroidism; Netherl	2015
Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. Endocrine journal, 2015, Volume: 62, Issue:10 Topics: Animals; Antioxidants; Asymptomatic Diseases; Behavior, Animal; Brain-Derived Neurotrophic Factor; D	2015
LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation. Lipids in health and disease, 2015, Aug-25, Volume: 14 Topics: Asymptomatic Diseases; Atherosclerosis; Body Mass Index; Carotid Intima-Media Thickness; Female; Hum	2015
The relationship between oxidative stress and autoimmunity in Hashimoto's thyroiditis. European journal of endocrinology, 2015, Volume: 173, Issue:6 Topics: Adult; Aryldialkylphosphatase; Asymptomatic Diseases; Autoantibodies; Autoimmunity; Carboxylic Ester	2015
Screening of subclinical hypothyroidism during gestational diabetes in Pakistani population. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016, Volume: 29, Issue:13 Topics: Adult; Asymptomatic Diseases; Case-Control Studies; Diabetes, Gestational; Female; Humans; Hypothyro	2016
Five-year prospective evaluation of thyroid function in girls with subclinical mild hypothyroidism of different etiology. European journal of endocrinology, 2015, Volume: 173, Issue:6 Topics: Adolescent; Asymptomatic Diseases; Autoantibodies; Case-Control Studies; Child; Child, Preschool; Di	2015
Evaluation of Thyroid Hormone Status in Children with Steroid Resistant Nephrotic Syndrome: A North India Study. Endocrine, metabolic & immune disorders drug targets, 2015, Volume: 15, Issue:4 Topics: Asymptomatic Diseases; Child; Child, Preschool; Creatinine; Cross-Sectional Studies; Disease Progres	2015
Individualized Follow-up of Pregnant Women with Asymptomatic Autoimmune Thyroid Disease. International journal of molecular sciences, 2016, Jan-12, Volume: 17, Issue:1 Topics: Adult; Asymptomatic Diseases; Autoantibodies; Case-Control Studies; Drug Monitoring; Female; Follow-	2016
Atherogenic Lipoproteins in Subclinical Hypothyroidism and Their Relationship with Hepatic Lipase Activity: Response to Replacement Treatment with Levothyroxine. Thyroid : official journal of the American Thyroid Association, 2016, Volume: 26, Issue:3 Topics: Adult; Aged; Asymptomatic Diseases; Biomarkers; Case-Control Studies; Cholesterol; Cross-Sectional S	2016
Effects of Levothyroxine Therapy on Pregnancy Outcomes in Women with Subclinical Hypothyroidism. Thyroid : official journal of the American Thyroid Association, 2016, Volume: 26, Issue:7 Topics: Abortion, Spontaneous; Adult; Apgar Score; Asymptomatic Diseases; Case-Control Studies; Diabetes, Ge	2016
Is there an association between subclinical hypothyroidism and preterm uterine contractions? A prospective observational study The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2017, Volume: 30, Issue:8 Topics: Adult; Asymptomatic Diseases; Case-Control Studies; Female; Humans; Hypothyroidism; Obstetric Labor,	2017
Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus. The Korean journal of internal medicine, 2016, Volume: 31, Issue:4 Topics: Adult; Age Distribution; Aged; Asymptomatic Diseases; Biomarkers; Blood Glucose; Chi-Square Distribu	2016
Five-Year Prospective Evaluation of Thyroid Function Test Evolution in Children with Hashimoto's Thyroiditis Presenting with Either Euthyroidism or Subclinical Hypothyroidism. Thyroid : official journal of the American Thyroid Association, 2016, Volume: 26, Issue:10 Topics: Adolescent; Asymptomatic Diseases; Child; Child, Preschool; Cohort Studies; Disease Progression; Fem	2016
Anti-Thyrotropin Autoantibodies in Patients with Macro-Thyrotropin and Long-Term Changes in Macro-Thyrotropin and Serum Thyrotropin Levels. Thyroid : official journal of the American Thyroid Association, 2017, Volume: 27, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Asymptomatic Diseases; Autoantibodies; Child; Chromatography, Gel; F	2017
Prevalence of depression in patients affected by subclinical hypothyroidism. Panminerva medica, 2010, Volume: 52, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Asymptomatic Diseases; Autoantibodies; Biomarkers; Chi-Square Distri	2010
Innate immune activity in plaque of patients with untreated and L-thyroxine-treated subclinical hypothyroidism. The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:4 Topics: Aged; Asymptomatic Diseases; Atherectomy; Case-Control Studies; Female; Hormone Replacement Therapy;	2011
The association of insulin resistance with subclinical thyrotoxicosis. Thyroid : official journal of the American Thyroid Association, 2011, Volume: 21, Issue:9 Topics: Adolescent; Adult; Analysis of Variance; Argentina; Asymptomatic Diseases; Biomarkers; Blood Glucose	2011
Mild thyroid hormone excess is associated with a decreased physical function in elderly men. The aging male : the official journal of the International Society for the Study of the Aging Male, 2011, Volume: 14, Issue:4 Topics: Aged; Aged, 80 and over; Asymptomatic Diseases; Cross-Sectional Studies; Exercise Test; Female; Hand	2011
Early levothyroxine treatment on maternal subclinical hypothyroidism improves spatial learning of offspring in rats. Journal of neuroendocrinology, 2012, Volume: 24, Issue:5 Topics: Animals; Animals, Newborn; Asymptomatic Diseases; Congenital Hypothyroidism; Female; Hypothyroidism;	2012
A high normal TSH level is associated with an atherogenic lipid profile in euthyroid non-smokers with newly diagnosed asymptomatic coronary heart disease. Lipids in health and disease, 2012, Mar-27, Volume: 11 Topics: Aged; Aged, 80 and over; Asymptomatic Diseases; Blood Glucose; Cholesterol; Coronary Disease; Dyslip	2012
Relationship of subclinical thyroid disease to the incidence of gestational diabetes. Obstetrics and gynecology, 2012, Volume: 119, Issue:5 Topics: Adult; Asymptomatic Diseases; Biomarkers; Cohort Studies; Diabetes, Gestational; Female; Humans; Hyp	2012
Evaluation of left ventricular systolic asynchrony in patients with subclinical hypothyroidism. Cardiology journal, 2012, Volume: 19, Issue:4 Topics: Adult; Asymptomatic Diseases; Biomarkers; Case-Control Studies; Echocardiography, Doppler, Color; Ec	2012
Hypothyroidism. Australian family physician, 2012, Volume: 41, Issue:8 Topics: Asymptomatic Diseases; Drug Interactions; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Compl	2012
Evaluation of protein oxidation and its association with lipid peroxidation and thyrotropin levels in overt and subclinical hypothyroidism. Endocrine, 2013, Volume: 44, Issue:1 Topics: Adult; Asymptomatic Diseases; Case-Control Studies; Female; Humans; Hypothyroidism; Lipid Peroxidati	2013

thyroxine and Asymptomatic Conditions