thyroxine and Angor Pectoris studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

Excerpt	Relevance	Reference
"The lipid-lowering effect of etiroxate was studied in a double-blind cross-over trial comprising 183 patients with hyperlipoproteinaemia, most of whom had suffered myocardial infarction or exhibited confirmed coronary insufficiency."	9.04	[The effect of etiroxate on serum lipids after myocardial infarction or in angina pectoris]. ( Etzel, V; Hoffmann, H; Nijssen, J; Schwartzkopff, W, 1976)
"The lipid-lowering effect of etiroxate was studied in a double-blind cross-over trial comprising 183 patients with hyperlipoproteinaemia, most of whom had suffered myocardial infarction or exhibited confirmed coronary insufficiency."	5.04	[The effect of etiroxate on serum lipids after myocardial infarction or in angina pectoris]. ( Etzel, V; Hoffmann, H; Nijssen, J; Schwartzkopff, W, 1976)
" TSH, free thyroxine, serum lipid levels and high-sensitivity C-reactive protein levels were measured and compared to the severity of coronary artery disease."	3.74	Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients. ( Ahn, YK; Jeong, JW; Jeong, MH; Kim, NH; Lee, EM; Lee, J; Oh, SK; Rhee, SJ; Yoo, NJ; Yun, KH, 2007)
"Therapeutic use of the potent antiarrhythmic drug amiodarone requires early detection of impending hyperthyroidism, a potentially life-threatening adverse reaction in cardiac patients."	3.67	Amiodarone-treated patients with suppressed TSH test are at risk of thyrotoxicosis. ( Stäubli, M; Studer, H, 1985)
" All were taking large daily doses of propranolol--480 +/- 155 (+/- SE) mg--for treatment of angina pectoris."	3.66	Hyperthyroxinemia in patients treated with high-dose propranolol. ( Cooper, DS; Daniels, GH; Ladenson, PW; Ridgway, EC, 1982)
" By the time the thyroid function stabilized, three times as much as preoperative dosage of thyroxin had to be administered for 34 days."	1.28	[A case of aorto-coronary bypass surgery in a hypophysectomized male patient]. ( Fujita, Y; Kasuya, S; Katagiri, M; Matsuoka, A; Ohtsuka, H; Okabe, M; Sakashita, J; Takahashi, M, 1990)
"The triiodothyronine level was lower on the 2nd day of the disease, the thyroxine content decreased on the 10th day of the disease but became normal on the 20-25th day."	1.26	[Thyroid hormones, cholesterol, erythrocyte aggregation and fibrinogen degradation products in acute myocardial infarct]. ( Kellner, K; Liusov, VA; Marek, H; Rudakov, AV; Titlbach, O, 1980)
" In spite of the high iodine content, amiodarone does not, therefore, depress thyroid function to any important degree during chronic administration and its antianginal action does not appear to be caused by the production of generalized hypothyroidism."	1.25	Effects of amiodarone on thyroid function in patients with ischaemic heart disease. ( Hurley, PJ; Pritchard, DA; Singh, BN, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (77.55)	18.7374
1990's	3 (6.12)	18.2507
2000's	6 (12.24)	29.6817
2010's	2 (4.08)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Brozaitiene, J	1
Mickuviene, N	1
Podlipskyte, A	1
Burkauskas, J	1
Bunevicius, R	1
Mustafa, C	1
Ozgül, U	1
Zehra, GC	1
Hülya, C	1
STARR, P	1
TAXAY, EP	1
MOSES, C	1
JABLONSKI, JR	1
SUNDER, JH	1
KATZ, LB	1
PADILLA, T	4
PADILLA, MA	2
PADILLA, LT	2
BEST, MM	1
DUNCAN, CH	1
ROBINSON, RW	1
LEBEAU, RJ	1
ACKERMAN, RF	1
BLACKET, RB	1
WOODHILL, J	1
BROWN, WD	1
Evrengul, H	1
Tanriverdi, H	1
Enli, Y	1
Kuru, O	1
Seleci, D	1
Bastemir, M	1
Kilic, A	1
Kaftan, A	1
Kilic, M	1
Yun, KH	1
Jeong, MH	1
Oh, SK	1
Lee, EM	1
Lee, J	1
Rhee, SJ	1
Yoo, NJ	1
Kim, NH	1
Ahn, YK	1
Jeong, JW	1
Taguchi, T	1
Iwasaki, Y	1
Asaba, K	1
Takao, T	1
Hashimoto, K	1
Casella, F	1
Bossi, I	1
Pisano, G	1
Montano, N	1
Levine, HD	1
Featherstone, HJ	1
Stewart, DK	1
Pimenov, LT	1
Leshchinskiĭ, LA	1
Cooper, DS	1
Daniels, GH	1
Ladenson, PW	1
Ridgway, EC	1
Shannon, LJ	1
Marek, H	1
Titlbach, O	1
Kellner, K	1
Liusov, VA	1
Rudakov, AV	1
Cummings, JF	1
Davies, R	1
Newton, RW	1
Thompson, CJ	1
Peters, A	1
Ehlers, M	1
Blank, B	1
Exler, D	1
Falk, C	1
Kohlmann, T	1
Fruehwald-Schultes, B	1
Wellhoener, P	1
Kerner, W	1
Fehm, HL	1
Friberg, L	1
Werner, S	1
Eggertsen, G	1
Ahnve, S	1
Kuch, J	1
Ceremuzyński, L	2
Lada, W	2
Schwartzkopff, W	1
Hoffmann, H	1
Nijssen, J	1
Etzel, V	1
Matwiszyn, B	1
Lawecki, J	1
Bommer, J	1
Speders, H	1
Ehrke, V	1
Paine, TD	1
Rogers, WJ	1
Baxley, WA	1
Russell, RO	1
Pritchard, DA	1
Singh, BN	1
Hurley, PJ	1
Ellyin, FM	1
Kumar, Y	2
Somberg, JC	1
Fujita, Y	1
Sakashita, J	1
Kasuya, S	1
Katagiri, M	1
Matsuoka, A	1
Okabe, M	1
Ohtsuka, H	1
Takahashi, M	1
Koike, R	1
Suma, H	1
Oku, T	1
Satoh, H	1
Sawada, Y	1
Matsuyama, N	1
Takeuchi, A	1
Funauchi, T	1
Ishimura, T	1
Wakabayashi, A	1
Ellyin, F	1
Fuh, CY	1
Singh, SP	1
Levey, GS	1
Kirk, SJ	1
O'Kane, HO	1
Morton, P	1
Gel'shteĭn, GG	1
Fitilev, SB	1
Saprygin, DB	1
Migalina, LA	1
Besshapov, EP	1
Stäubli, M	1
Studer, H	1
Greene, R	1
Messini, M	1
Koschinsky, T	1
Vogelberg, KH	1
Gries, FA	1
Klemens, UH	1
von Löwis, P	1
Phipps, FC	1
Stokinger, HE	1
Likoff, W	1
Lyngborg, K	1
Jacobsen, JG	1
Gertler, MM	1
Leetma, HE	1
Saluste, E	1
Welsh, JJ	1
Rusk, HA	1
Covalt, DA	1
Rosenberger, J	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Endocrine Changes in Adults Undergoing Cardiac Surgery[NCT03736499]				500 participants (Anticipated)	Observational	2018-07-01	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[The effect of etiroxate on serum lipids after myocardial infarction or in angina pectoris]. Medizinische Klinik, 1976, Sep-17, Volume: 71, Issue:38 Topics: Angina Pectoris; Blood Coagulation; Clinical Trials as Topic; Heart; Humans; Hypercholesterolemia; L	1976
[Treatment of primary hyperlipoproteinemia type IIa and IIb with dextrothyroxine (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1974, Mar-15, Volume: 99, Issue:11 Topics: Administration, Oral; Angina Pectoris; Body Weight; Cholesterol; Evaluation Studies as Topic; Female	1974
[Treatment of primary lipoproteinemia type IIa and IIb with highly purified dextro-thyroxine (D-T4). Controlled study in ambulant conditions]. Deutsche medizinische Wochenschrift (1946), 1974, Mar-15, Volume: 99, Issue:11 Topics: Administration, Oral; Ambulatory Care; Angina Pectoris; Animals; Body Weight; Cholesterol; Female; H	1974

Article	Year
Relationship and prognostic importance of thyroid hormone and N-terminal pro-B-Type natriuretic peptide for patients after acute coronary syndromes: a longitudinal observational study. BMC cardiovascular disorders, 2016, Feb-18, Volume: 16 Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; C-Reactive Protein; Coronary Artery Disease; Female;	2016
Transient ST-segment elevation due to iatrogenic hyperthyroidism in a patient with normal coronary arteries. Internal medicine (Tokyo, Japan), 2011, Volume: 50, Issue:15 Topics: Angina Pectoris; Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Electrocardiography; Hu	2011
Sodium dextrothyroxine and sodium levothyroxine. Results of their use in an athyreotic patient with angina pectoris and hypercholesteremia. JAMA, 1960, Aug-27, Volume: 173 Topics: Angina Pectoris; Cholesterol; Dextrothyroxine; Humans; Hypercholesterolemia; Thyroid Gland; Thyroxin	1960
Clinical evaluation of a thyroid analog in patients with hypercholesterolemia, angina, claudication and diabetes. The American journal of the medical sciences, 1962, Volume: 244 Topics: Angina Pectoris; Diabetes Complications; Diabetes Mellitus; Humans; Hypercholesterolemia; Intermitte	1962
The use of sodium dextro-thyroxin in patients with angina pectoris. The American journal of the medical sciences, 1962, Volume: 244 Topics: Angina Pectoris; Humans; Sodium; Thyroxine	1962
[Clinical evaluation of sodium dextrothyroxine in hypercholesterolemic patients with angina pectoris]. El Dia medico, 1962, Nov-22, Volume: 34 Topics: Angina Pectoris; Dextrothyroxine; Humans; Hypercholesterolemia; Thyroxine	1962
EFFECTS OF CHOLESTEROL-LOWERING DRUGS ON SERUM TRIGLYCERIDES. JAMA, 1964, Jan-04, Volume: 187 Topics: Androsterone; Angina Pectoris; Arteriosclerosis; Cholesterol; Diabetes Mellitus; Humans; Lipids; Myo	1964
DEXTRO-THYROXINE AS A CHOLESTEROL-LOWERING AGENT IN PATIENTS WITH ANGINA PECTORIS. Circulation, 1963, Volume: 28 Topics: Angina Pectoris; Cholesterol; Diethylstilbestrol; Pharmacology; Thyroxine	1963
[CLINICAL EVALUATION OF SODIC DEXTRO-THYROXIN IN PATIENTS WITH HYPERCHOLESTEROLEMIC ANGINA PECTORIS]. Hospital (Rio de Janeiro, Brazil), 1963, Volume: 64 Topics: Angina Pectoris; Hypercholesterolemia; Thyroxine	1963
PROLONGED ADMINISTRATION OF DEXTROTHYROXINE IN CARDIOVASCULAR PATIENTS. Memphis and Mid-South medical journal, 1964, Volume: 39 Topics: Angina Pectoris; Cardiovascular Diseases; Cholesterol; Dextrothyroxine; Diet; Diet Therapy; Humans;	1964
THE EFFECT OF CHOLESTYRAMINE ("MK 135") ON THE SERUM CHOLESTEROL LEVEL IN MAN. The Medical journal of Australia, 1964, Jul-04, Volume: 2 Topics: Angina Pectoris; Cholesterol; Cholestyramine Resin; Coronary Disease; Humans; Leg; Male; Myocardial	1964
TREATMENT of angina pectoris. Lancet (London, England), 1955, Apr-23, Volume: 268, Issue:6869 Topics: Angina Pectoris; Humans; Iodine; Iodine Radioisotopes; Thyroxine	1955
Interaction of plasma homocysteine and thyroid hormone concentrations in the pathogenesis of the slow coronary flow phenomenon. Cardiology, 2007, Volume: 108, Issue:3 Topics: Aged; Angina Pectoris; Blood Flow Velocity; Case-Control Studies; Coronary Angiography; Coronary Cir	2007
Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients. International journal of cardiology, 2007, Oct-31, Volume: 122, Issue:1 Topics: Aged; Angina Pectoris; C-Reactive Protein; Coronary Artery Disease; Female; Humans; Lipids; Male; Mi	2007
Myxedema coma and cardiac ischemia in relation to thyroid hormone replacement therapy in a 38-year-old Japanese woman. Clinical therapeutics, 2007, Volume: 29, Issue:12 Topics: Adult; Angina Pectoris; Chest Pain; Coronary Angiography; Coronary Artery Bypass; Coronary Stenosis;	2007
An atypical case of typical chest pain. Internal and emergency medicine, 2008, Volume: 3, Issue:4 Topics: Administration, Cutaneous; Administration, Sublingual; Aged; Angina Pectoris; Chest Pain; Diagnosis,	2008
Compromise therapy in the patient with angina pectoris and hypothyroidism. A clinical assessment. The American journal of medicine, 1980, Volume: 69, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Blood Transfusion; Cineangiography; Femal	1980
Angina in thyrotoxicosis. Thyroid-related coronary artery spasm. Archives of internal medicine, 1983, Volume: 143, Issue:3 Topics: Angina Pectoris; Angiography; Ergonovine; Humans; Hyperthyroidism; Isosorbide Dinitrate; Male; Middl	1983
[Thyroid hormone changes (iodothyroninemia) in patients with acute myocardial infarction, and their clinical significance]. Kardiologiia, 1984, Volume: 24, Issue:10 Topics: Adult; Angina Pectoris; Cardiomyopathy, Dilated; Humans; Middle Aged; Myocardial Infarction; Prognos	1984
Management of angina and hypothyroidism. British medical journal (Clinical research ed.), 1981, Jun-06, Volume: 282, Issue:6279 Topics: Angina Pectoris; Humans; Hypothyroidism; Thyroxine	1981
Hyperthyroxinemia in patients treated with high-dose propranolol. The American journal of medicine, 1982, Volume: 73, Issue:6 Topics: Aged; Angina Pectoris; Female; Humans; Male; Middle Aged; Propranolol; Thyrotropin-Releasing Hormone	1982
Cautionary tales from general practice. Australian family physician, 1982, Volume: 11, Issue:1 Topics: Aged; Angina Pectoris; Diagnostic Errors; Female; Heart Failure; Humans; Hypothyroidism; Thyroxine	1982
[Thyroid hormones, cholesterol, erythrocyte aggregation and fibrinogen degradation products in acute myocardial infarct]. Kardiologiia, 1980, Volume: 20, Issue:1 Topics: Adult; Aged; Angina Pectoris; Cholesterol; Coronary Disease; Erythrocyte Aggregation; Fibrin Fibrino	1980
Hypopituitarism following coronary artery bypass surgery. Scottish medical journal, 1997, Volume: 42, Issue:4 Topics: Aged; Angina Pectoris; Coronary Artery Bypass; Drug Therapy, Combination; Glucocorticoids; Humans; H	1997
Excess triiodothyronine as a risk factor of coronary events. Archives of internal medicine, 2000, Jul-10, Volume: 160, Issue:13 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Cross-Sectional Studies; Female; Humans; Logistic M	2000
Rapid down-regulation of thyroid hormones in acute myocardial infarction: is it cardioprotective in patients with angina? Archives of internal medicine, 2002, Jun-24, Volume: 162, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Biomarkers; Case-Control Studies; Down-Regulation;	2002
Thyroid activity coefficients in intractable angina pectoris. Acta medica Polona, 1975, Volume: 16, Issue:3 Topics: Adult; Angina Pectoris; Animals; Humans; Male; Middle Aged; Thyroid Function Tests; Thyroid Gland; T	1975
Patients with intractable angina: free thyroxine index, immunoreactive insulin and free fatty acids in blood, free adrenaline and noradrenaline in urine. European journal of cardiology, 1978, Volume: 7, Issue:5-6 Topics: Adult; Aged; Angina Pectoris; Diabetes Mellitus; Epinephrine; Fatty Acids, Nonesterified; Humans; In	1978
[Treatment of hypercholesterolemia after myocardial infarction with D-thyroxine (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1975, Jan-24, Volume: 117, Issue:4 Topics: Angina Pectoris; Blood Pressure; Body Weight; Female; Humans; Hypercholesterolemia; Male; Middle Age	1975
Coronary arterial surgery in patients with incapacitating angina pectoris and myxedema. The American journal of cardiology, 1977, Volume: 40, Issue:2 Topics: Aged; Angina Pectoris; Cardiac Catheterization; Coronary Vessels; Female; Heart Ventricles; Humans;	1977
Effects of amiodarone on thyroid function in patients with ischaemic heart disease. British heart journal, 1975, Volume: 37, Issue:8 Topics: Amiodarone; Angina Pectoris; Benzofurans; Blood Pressure; Cholesterol; Coronary Disease; Heart Rate;	1975
[A case of aorto-coronary bypass surgery in a hypophysectomized male patient]. Kyobu geka. The Japanese journal of thoracic surgery, 1990, Volume: 43, Issue:2 Topics: Angina Pectoris; Coronary Artery Bypass; Humans; Hydrocortisone; Hypophysectomy; Male; Middle Aged;	1990
A case of successful coronary artery bypass grafting in a patient with angina pectoris and hypothyroidism. Japanese circulation journal, 1989, Volume: 53, Issue:4 Topics: Angina Pectoris; Coronary Angiography; Female; Humans; Hypothyroidism; Internal Mammary-Coronary Art	1989
Hypothyroidism with angina pectoris. A clinical dilemma. Postgraduate medicine, 1986, May-15, Volume: 79, Issue:7 Topics: Angina Pectoris; Cardiac Catheterization; Coronary Artery Bypass; Female; Humans; Hypothyroidism; Is	1986
Hypothyroidism complicated by angina pectoris. Hospital practice (Office ed.), 1987, Aug-15, Volume: 22, Issue:8 Topics: Angina Pectoris; Female; Humans; Hypothyroidism; Middle Aged; Thyroid Hormones; Thyroxine	1987
Coronary artery surgery and myxoedema. British heart journal, 1987, Volume: 58, Issue:6 Topics: Adult; Angina Pectoris; Coronary Artery Bypass; Humans; Male; Myxedema; Thyroxine	1987
[Thyroid hormone content of the blood plasma and tolerance for physical loading in ischemic heart disease patients]. Kardiologiia, 1987, Volume: 27, Issue:6 Topics: Angina Pectoris; Coronary Circulation; Coronary Disease; Humans; Male; Middle Aged; Physical Enduran	1987
Amiodarone-treated patients with suppressed TSH test are at risk of thyrotoxicosis. Klinische Wochenschrift, 1985, Feb-15, Volume: 63, Issue:4 Topics: Adolescent; Adult; Aged; Amiodarone; Angina Pectoris; Arrhythmias, Cardiac; Benzofurans; Female; Hum	1985
Hypothyroidism and heart-disease. Lancet (London, England), 1970, Apr-04, Volume: 1, Issue:7649 Topics: Angina Pectoris; Heart Diseases; Humans; Hypothyroidism; Propranolol; Thyroxine	1970
[Therapy of angina pectoris. V. Various drugs. Surgical therapy and other therapeutic measures. General considerations]. La Clinica terapeutica, 1974, Mar-15, Volume: 68, Issue:5 Topics: Angina Pectoris; Antihypertensive Agents; Griseofulvin; Humans; Hypnotics and Sedatives; Nitroglycer	1974
Supraventricular tachycardia. II. British medical journal, 1971, Nov-13, Volume: 4, Issue:5784 Topics: Acetanilides; Adrenergic beta-Antagonists; Aged; Amino Alcohols; Angina Pectoris; Arrhythmia, Sinus;	1971
The influence of the thyroid on the acute toxicity of a dynamite-sensitizing mixture. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 139, Issue:1 Topics: Angina Pectoris; Animals; Epinephrine; Glycols; Hyperthyroidism; Hypothyroidism; Lethal Dose 50; Mal	1972
Symposium on arteriosclerotic heart disease. Medical management of angina pectoris. Geriatrics, 1972, Volume: 27, Issue:5 Topics: Acute Disease; Angina Pectoris; Arteriosclerosis; Cholesterol; Cholestyramine Resin; Clofibrate; Die	1972
Intractable paroxysmal tachycardia in thyrotoxicosis simulating myocardial infarction. Acta medica Scandinavica, 1972, Volume: 192, Issue:5 Topics: Angina Pectoris; Atrial Fibrillation; Bradycardia; Cardiac Catheterization; Diagnosis, Differential;	1972
Carbohydrate, insulin, and lipid interrelationship in ischemic vascular disease. Geriatrics, 1970, Volume: 25, Issue:5 Topics: Age Factors; Aged; Angina Pectoris; Blood Glucose; Blood Pressure; Body Height; Body Weight; Coronar	1970

thyroxine and Angor Pectoris

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